Clinical Features	CN_CNMF		METHLYATION_CNMF		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL		MIRSEQ_MATURE_CNMF		MIRSEQ_MATURE_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
TP53	114 (31%)	259	9.9999e-06	0.000609	0.15709	0.679	9.9999e-06	0.000609	3e-05	0.00158	2e-04	0.00932	0.00018	0.00891	0.00391	0.102	0.00047	0.0186
CTNNB1	97 (26%)	276	0.00025	0.011	9.9999e-06	0.000609	9.9999e-06	0.000609	9.9999e-06	0.000609	9.9999e-06	0.000609	9.9999e-06	0.000609	9.9999e-06	0.000609	9.9999e-06	0.000609
AXIN1	24 (6%)	349	0.00362	0.0989	0.02991	0.382	9.9999e-06	0.000609	0.0094699	0.198	9.9999e-06	0.000609	0.03496	0.403	0.0052099	0.125	0.84339	0.959
RB1	21 (6%)	352	0.053669	0.512	0.01455	0.242	0.03874	0.415	0.53291	0.851	0.01169	0.219	0.51771	0.849	0.40688	0.81	0.44509	0.819
ARID1A	32 (9%)	341	0.36496	0.795	0.59329	0.894	0.2848	0.766	0.21653	0.724	0.63805	0.91	0.72414	0.919	0.28234	0.766	0.96643	1
BAP1	21 (6%)	352	0.71391	0.919	9.9999e-06	0.000609	3e-05	0.00158	9.9999e-06	0.000609	0.00116	0.0399	0.00174	0.0551	0.00359	0.0989	0.00051999	0.0196
CDC27	15 (4%)	358	0.79647	0.949	0.22854	0.728	0.31488	0.784	0.39043	0.801	0.47196	0.819	0.50575	0.836	0.15669	0.679	0.12129	0.662
CDKN2A	11 (3%)	362	0.86113	0.961	0.18212	0.711	0.20647	0.717	0.66579	0.918	0.62697	0.901	0.57684	0.883	0.46817	0.819	0.20111	0.717
KRT2	12 (3%)	361	0.52603	0.851	0.29168	0.766	0.088499	0.604	0.2245	0.725	0.45227	0.819	0.42015	0.819	0.066169	0.552	0.48075	0.819
NFE2L2	13 (3%)	360	0.03133	0.388	0.6736	0.918	0.1497	0.677	0.097419	0.616	0.16029	0.679	0.075459	0.578	0.13612	0.677	0.02122	0.314
PTEN	11 (3%)	362	0.84903	0.959	0.067649	0.552	0.069759	0.559	0.03754	0.407	0.3555	0.795	0.03935	0.416	0.47218	0.819	0.14785	0.677
ARID2	22 (6%)	351	0.84446	0.959	0.47902	0.819	0.48212	0.819	0.74687	0.927	0.48821	0.82	0.49189	0.82	0.94569	1	0.31272	0.784
RBM10	8 (2%)	365	0.71018	0.919	0.19661	0.717	0.4423	0.819	0.77101	0.937	0.81659	0.951	0.75375	0.933	0.72716	0.919	0.2471	0.76
ZNF512B	8 (2%)	365	0.34409	0.788	0.81138	0.95	0.14341	0.677	0.58274	0.886	0.19701	0.717	0.86131	0.961	0.4517	0.819	1	1
KCNN3	12 (3%)	361	0.076859	0.578	0.29131	0.766	0.37818	0.795	0.60514	0.898	0.84029	0.959	0.40893	0.812	0.2778	0.766	0.064219	0.552
KRT10	9 (2%)	364	1	1	0.1253	0.662	0.2507	0.76	0.61269	0.898	0.5149	0.848	0.43618	0.819	0.12471	0.662	0.44949	0.819
APOB	39 (10%)	334	0.22598	0.725	0.54383	0.851	0.01419	0.242	0.01187	0.219	0.90022	0.981	0.21492	0.721	0.02311	0.327	0.01574	0.244
MLL4	19 (5%)	354	0.25615	0.764	0.23372	0.735	0.64164	0.91	0.46009	0.819	0.73698	0.919	0.69518	0.919	0.67775	0.918	0.83801	0.959
ALB	43 (12%)	330	0.04925	0.488	0.0487	0.488	0.53677	0.851	0.52346	0.851	0.27208	0.766	0.88466	0.974	0.41365	0.817	0.03401	0.403
TSC2	12 (3%)	361	0.054929	0.512	0.03558	0.403	0.00027	0.0113	0.00061999	0.0223	0.48103	0.819	0.82961	0.958	0.49063	0.82	0.57868	0.883
IL6ST	12 (3%)	361	0.02313	0.327	0.37136	0.795	0.68608	0.918	0.55158	0.86	0.067289	0.552	0.02138	0.314	0.76218	0.937	0.51801	0.849
C19ORF55	6 (2%)	367	0.3926	0.801	0.67229	0.918	0.72739	0.919	0.15733	0.679	0.78496	0.946	0.86891	0.966	0.078099	0.578	0.67423	0.918
PIK3CA	13 (3%)	360	1	1	1	1	0.52758	0.851	0.62828	0.901	0.37402	0.795	0.2062	0.717	0.46803	0.819	0.59087	0.893
CELA1	6 (2%)	367	0.76858	0.937	0.44345	0.819	0.88697	0.974	0.94806	1	0.21432	0.721	0.53629	0.851	1	1	0.89348	0.976
RPS6KA3	14 (4%)	359	0.2886	0.766	0.20502	0.717	0.32288	0.787	0.3424	0.788	0.54315	0.851	0.89946	0.981	0.29473	0.768	0.94707	1
NRD1	13 (3%)	360	0.87782	0.97	0.82501	0.955	0.29101	0.766	0.45449	0.819	0.72069	0.919	0.37936	0.795	0.18466	0.711	0.8025	0.95
EEF1A1	9 (2%)	364	0.02794	0.369	0.39282	0.801	0.39979	0.804	0.33301	0.788	0.68327	0.918	0.060619	0.552	0.32455	0.788	0.72409	0.919
TCHH	17 (5%)	356	0.0097399	0.198	0.077109	0.578	0.69725	0.919	0.97133	1	0.76929	0.937	0.8021	0.95	0.33223	0.788	0.94729	1
COG2	4 (1%)	369	0.68562	0.918	0.36615	0.795	0.11592	0.662	0.16823	0.692	0.88424	0.974	0.37374	0.795	1	1	0.36261	0.795
ATXN1	10 (3%)	363	0.66138	0.918	0.65776	0.918	0.28487	0.766	0.83741	0.959	0.19812	0.717	0.7087	0.919	0.03132	0.388	0.20829	0.717
KCTD20	5 (1%)	368	1	1	0.31919	0.784	0.050629	0.495	0.069909	0.559	0.47378	0.819	0.18537	0.711	0.83205	0.959	0.72892	0.919
GPR110	6 (2%)	367	0.76988	0.937	0.44152	0.819	0.03641	0.403	0.054779	0.512	0.065219	0.552	0.0067199	0.157	0.72578	0.919	0.0051999	0.125
CEP164	9 (2%)	364	0.57278	0.882	1	1	0.80732	0.95	0.67898	0.918	0.85808	0.961	0.98344	1	1	1	0.7793	0.942
TCEAL6	4 (1%)	369	0.68448	0.918	0.36723	0.795	0.11566	0.662	0.16734	0.692	0.88773	0.974	0.3741	0.795	1	1	0.36268	0.795
DNAJC28	4 (1%)	369	0.45977	0.819	0.82148	0.953	0.20599	0.717	0.18675	0.711	0.88601	0.974	0.10445	0.631	0.37243	0.795	0.88973	0.974
FOXI1	5 (1%)	368	0.37605	0.795	0.6155	0.898	0.14159	0.677	0.091789	0.606	0.55137	0.86	0.24296	0.755	0.87142	0.966	0.70431	0.919
KRTAP5-7	4 (1%)	369	0.46276	0.819	0.46721	0.819	0.91772	0.986	0.077939	0.578	0.17046	0.692	0.52824	0.851	0.00323	0.0947	0.25597	0.764
JAK1	14 (4%)	359	0.69664	0.919	1	1	0.29046	0.766	0.14565	0.677	0.9643	1	0.82104	0.953	0.20151	0.717	0.34445	0.788
DENND4B	12 (3%)	361	0.29316	0.766	0.2684	0.766	0.14251	0.677	0.61468	0.898	0.04668	0.474	0.53693	0.851	1	1	0.34711	0.791
BRD7	10 (3%)	363	0.65863	0.918	0.51134	0.844	0.35038	0.795	0.5978	0.894	0.57048	0.882	0.17303	0.692	0.80074	0.95	0.12937	0.67
IDH1	8 (2%)	365	0.48195	0.819	0.24994	0.76	0.14106	0.677	0.23529	0.737	0.21011	0.72	0.38992	0.801	0.38823	0.801	0.17378	0.692
CNGA3	11 (3%)	362	0.14222	0.677	0.92777	0.992	0.59476	0.894	0.21488	0.721	0.65163	0.918	0.33031	0.788	0.67451	0.918	0.43872	0.819
PLA2G3	6 (2%)	367	0.39075	0.801	0.097379	0.616	0.16441	0.692	0.12646	0.663	0.37215	0.795	0.01326	0.234	0.7233	0.919	0.03661	0.403
HLA-DPB1	5 (1%)	368	1	1	0.31744	0.784	0.48034	0.819	0.28126	0.766	0.17115	0.692	0.77576	0.939	0.68469	0.918	0.40411	0.808
ALMS1	24 (6%)	349	0.49174	0.82	0.17852	0.703	0.78866	0.948	0.98066	1	0.43903	0.819	0.69999	0.919	0.48517	0.82	0.70195	0.919
NUCB2	3 (1%)	370	0.61664	0.898	0.47194	0.819	NA	NA	NA	NA	0.39704	0.802	0.44524	0.819	0.01469	0.242	0.84282	0.959
BAZ2A	11 (3%)	362	0.46643	0.819	0.35363	0.795	0.97315	1	0.68261	0.918	0.42308	0.819	0.57888	0.883	0.076569	0.578	0.59639	0.894
TAF1B	6 (2%)	367	0.2047	0.717	0.095239	0.613	0.083759	0.59	0.6582	0.918	0.80834	0.95	0.80489	0.95	0.46256	0.819	0.26998	0.766
C1ORF125	11 (3%)	362	0.33587	0.788	0.067259	0.552	0.67743	0.918	0.81293	0.95	0.18515	0.711	0.01548	0.244	0.079909	0.586	0.22563	0.725
AR	10 (3%)	363	0.47289	0.819	1	1	0.71228	0.919	0.72607	0.919	0.47408	0.819	0.17132	0.692	0.20487	0.717	0.66061	0.918
SPHK1	6 (2%)	367	0.39469	0.801	0.76972	0.937	0.03652	0.403	0.01068	0.211	0.52443	0.851	0.093739	0.612	0.11615	0.662	0.10545	0.633
CREB3L3	5 (1%)	368	0.091279	0.606	0.44909	0.819	0.13415	0.677	0.61893	0.898	0.3664	0.795	0.081569	0.59	1	1	0.15983	0.679
LFNG	7 (2%)	366	0.49571	0.823	0.62308	0.9	0.6998	0.919	0.90524	0.982	0.44069	0.819	0.46377	0.819	0.75921	0.937	0.53497	0.851
FZR1	6 (2%)	367	0.57891	0.883	1	1	0.31809	0.784	0.46596	0.819	0.79096	0.948	0.02926	0.38	0.20046	0.717	0.087689	0.604
TRIOBP	11 (3%)	362	1	1	0.12105	0.662	0.33946	0.788	0.3756	0.795	0.37741	0.795	0.46618	0.819	0.098069	0.616	0.4016	0.805
GJB1	3 (1%)	370	1	1	0.79448	0.948	0.26177	0.766	0.72987	0.919	0.22549	0.725	0.90954	0.982	0.15279	0.679	1	1
DYRK1A	7 (2%)	366	0.03246	0.396	0.89069	0.974	0.83806	0.959	0.63439	0.907	0.26116	0.766	0.48179	0.819	0.76791	0.937	0.29297	0.766
TNPO1	9 (2%)	364	0.43403	0.819	0.90816	0.982	0.34329	0.788	0.50461	0.836	0.61076	0.898	0.46557	0.819	0.186	0.711	0.62949	0.902
PDZD4	4 (1%)	369	0.3038	0.779	1	1	0.72877	0.919	0.24924	0.76	0.49593	0.823	0.28636	0.766	NA	NA	NA	NA
CCNA2	5 (1%)	368	0.45623	0.819	0.72951	0.919	0.094299	0.612	0.78896	0.948	0.23698	0.739	0.21239	0.721	0.39905	0.804	0.25654	0.764
AHCTF1	8 (2%)	365	0.54134	0.851	0.81166	0.95	0.60029	0.895	0.73606	0.919	0.54008	0.851	0.97801	1	0.90854	0.982	0.97786	1
RXRB	8 (2%)	365	0.81585	0.951	0.65987	0.918	0.4279	0.819	0.76055	0.937	0.49034	0.82	0.81135	0.95	0.92112	0.987	0.87606	0.969
PARP1	5 (1%)	368	0.53882	0.851	0.85711	0.961	0.27156	0.766	0.65895	0.918	0.34109	0.788	0.59848	0.894	0.61772	0.898	0.53311	0.851
NBEA	21 (6%)	352	0.68531	0.918	0.40598	0.81	0.85945	0.961	0.91115	0.982	0.27874	0.766	0.15037	0.677	0.73259	0.919	0.70472	0.919
H6PD	5 (1%)	368	0.53818	0.851	0.61549	0.898	0.26843	0.766	0.15209	0.679	0.4293	0.819	0.12011	0.662	0.87093	0.966	0.3125	0.784
VPS4B	5 (1%)	368	0.73817	0.919	0.04454	0.458	0.087609	0.604	0.28959	0.766	0.75996	0.937	0.30247	0.778	0.20103	0.717	0.072119	0.571
HNRNPL	8 (2%)	365	0.54021	0.851	0.30696	0.784	0.02645	0.368	0.29678	0.768	0.283	0.766	0.76408	0.937	0.70156	0.919	0.59741	0.894
FILIP1	13 (3%)	360	0.82026	0.953	0.3659	0.795	0.29677	0.768	0.4461	0.819	0.72194	0.919	0.37666	0.795	0.48722	0.82	0.5715	0.882
FAM22F	4 (1%)	369	0.13088	0.673	0.090759	0.606	0.02767	0.369	0.31995	0.784	0.73738	0.919	0.39467	0.801	0.084199	0.59	0.27885	0.766
GPSM2	4 (1%)	369	0.45733	0.819	0.68946	0.918	0.67772	0.918	0.87164	0.966	0.96912	1	0.64146	0.91	0.083279	0.59	0.84475	0.959
RCCD1	5 (1%)	368	0.31154	0.784	0.85666	0.961	0.78274	0.945	0.46483	0.819	0.71368	0.919	0.4561	0.819	0.34758	0.791	0.62534	0.9
PTGR1	5 (1%)	368	0.21982	0.725	0.61721	0.898	0.84	0.959	0.44517	0.819	0.92912	0.992	0.32092	0.784	0.81205	0.95	0.19241	0.717
SAMM50	3 (1%)	370	0.61663	0.898	0.61136	0.898	0.11494	0.662	0.16886	0.692	0.5317	0.851	0.099979	0.619	0.86392	0.962	0.14374	0.677
PBRM1	9 (2%)	364	0.43106	0.819	0.20537	0.717	0.0095099	0.198	0.0076999	0.174	0.27936	0.766	0.01127	0.218	0.51907	0.849	0.16623	0.692
SGK269	8 (2%)	365	1	1	0.089659	0.606	0.27404	0.766	0.64255	0.91	0.58402	0.886	0.33039	0.788	0.22405	0.725	0.01559	0.244
LEO1	5 (1%)	368	0.14286	0.677	0.38064	0.795	0.80259	0.95	0.17516	0.694	0.43081	0.819	0.33379	0.788	0.26519	0.766	0.7048	0.919
CD97	5 (1%)	368	0.45679	0.819	0.85365	0.961	0.36804	0.795	0.14647	0.677	0.73476	0.919	0.1849	0.711	0.32815	0.788	0.52092	0.851
SKA3	4 (1%)	369	0.68523	0.918	0.2186	0.725	0.4196	0.819	0.71581	0.919	0.2815	0.766	0.94225	1	0.37465	0.795	0.8465	0.959
CBX4	6 (2%)	367	0.14448	0.677	0.33635	0.788	0.00226	0.0688	0.00398	0.102	0.33316	0.788	0.48744	0.82	0.053829	0.512	0.32026	0.784
MTA1	6 (2%)	367	1	1	0.12011	0.662	0.03999	0.417	0.28886	0.766	0.057309	0.528	0.066649	0.552	0.46304	0.819	0.15964	0.679
CRIP3	6 (2%)	367	0.00148	0.0488	0.15019	0.677	0.37994	0.795	0.7708	0.937	0.39351	0.801	0.39376	0.801	0.25452	0.764	0.12257	0.662
NR4A2	6 (2%)	367	1	1	0.57944	0.883	0.27077	0.766	0.11098	0.658	0.68369	0.918	0.11421	0.662	0.80929	0.95	0.14921	0.677
HNF1A	8 (2%)	365	0.01888	0.288	1	1	0.067349	0.552	0.31733	0.784	0.064119	0.552	0.20742	0.717	0.12474	0.662	0.28659	0.766
KRAS	6 (2%)	367	0.28958	0.766	0.67325	0.918	0.54342	0.851	0.19007	0.717	0.69122	0.919	0.1221	0.662	0.17375	0.692	0.60666	0.898
PGBD1	3 (1%)	370	0.79004	0.948	0.79321	0.948	1	1	0.41149	0.815	0.56052	0.872	0.82711	0.956	0.46209	0.819	0.90894	0.982
LATS1	7 (2%)	366	0.70776	0.919	0.6243	0.9	0.57341	0.882	0.14499	0.677	0.85663	0.961	0.67194	0.918	1	1	0.61413	0.898
KEAP1	17 (5%)	356	0.23075	0.728	0.13968	0.677	0.27326	0.766	0.93967	1	0.10112	0.621	0.25148	0.76	0.72443	0.919	0.2301	0.728
SENP6	11 (3%)	362	0.3953	0.801	0.074429	0.578	0.79339	0.948	0.22292	0.725	0.46694	0.819	0.42958	0.819	0.10359	0.631	0.92951	0.992
FKBP4	4 (1%)	369	0.46099	0.819	0.56967	0.882	0.8379	0.959	0.67467	0.918	0.83896	0.959	0.64106	0.91	1	1	0.31239	0.784
FOXK2	6 (2%)	367	1	1	0.14747	0.677	0.0081399	0.179	0.74221	0.923	0.45549	0.819	0.33897	0.788	0.22933	0.728	0.36746	0.795
DSPP	21 (6%)	352	0.35903	0.795	0.91971	0.987	0.73699	0.919	0.21249	0.721	0.91278	0.982	0.44175	0.819	0.77216	0.937	0.22272	0.725
C10ORF28	4 (1%)	369	0.68438	0.918	0.46975	0.819	1	1	0.16595	0.692	0.03616	0.403	0.84917	0.959	0.01328	0.234	0.15992	0.679
PRAMEF4	4 (1%)	369	0.68193	0.918	0.36346	0.795	0.33384	0.788	0.56141	0.872	0.18958	0.717	0.15922	0.679	0.68949	0.918	0.25036	0.76
RPS6KA5	5 (1%)	368	1	1	0.31751	0.784	0.61872	0.898	0.33149	0.788	0.31267	0.784	0.4256	0.819	0.28464	0.766	0.5226	0.851
DDX42	6 (2%)	367	0.20216	0.717	0.20796	0.717	0.15505	0.679	0.02779	0.369	0.25143	0.76	0.062579	0.552	0.34114	0.788	0.22235	0.725
RHCG	4 (1%)	369	0.12869	0.67	0.36519	0.795	0.27467	0.766	0.26044	0.766	0.68538	0.918	0.083699	0.59	0.91231	0.982	0.12287	0.662
SWAP70	5 (1%)	368	0.85447	0.961	1	1	0.28636	0.766	0.74919	0.929	0.6203	0.898	0.69441	0.919	0.11138	0.658	0.38797	0.801
BIN1	4 (1%)	369	0.30245	0.778	0.68729	0.918	0.59055	0.893	0.48423	0.82	0.68143	0.918	0.099709	0.619	0.91231	0.982	0.12532	0.662
SMARCA4	11 (3%)	362	0.13488	0.677	0.42705	0.819	0.33954	0.788	0.47637	0.819	0.73588	0.919	0.19674	0.717	0.14619	0.677	0.37231	0.795