rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(7) 395753 7 7 7 0 1 2 0 4 0 0 0.187 0.000579 0.356 2 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 CTSD(1), ESR1(6), GREB1(12), HSPB1(1), HSPB2(1), MTA1(6), PDZK1(4), TUBA8(2) 6506963 33 32 31 2 3 13 6 7 4 0 0.000993 0.00231 0.711 3 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCL11(1), CCR3(3), CFL1(1), GNAQ(1), GNAS(10), GNB1(2), LIMK1(4), MAPK1(3), NOX1(3), PIK3C2G(7), PLCB1(8), PPP1R12B(4), PRKCA(1), PTK2(9), RAF1(2), ROCK2(3) 14537713 62 52 59 2 7 16 7 22 10 0 2.34e-05 0.00982 1.000 4 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(3), LPO(4), MPO(5), PRDX1(1), PRDX2(2), PRDX6(1), TPO(13), TYR(5) 5528691 34 31 34 3 2 6 8 11 7 0 0.00756 0.00984 1.000 5 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(2), ATP6V0C(2), CAT(1), EPX(3), LPO(4), MPO(5), PRDX1(1), PRDX2(2), PRDX6(1), SHMT1(2), SHMT2(4), TPO(13) 6710725 40 34 40 3 2 9 6 11 12 0 0.00588 0.0169 1.000 6 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(3), GNAQ(1), GNB1(2), HTR2C(3), PLCB1(8), TUB(3) 3981712 20 18 20 1 1 3 2 6 8 0 0.0640 0.0270 1.000 7 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(1), PTK2B(5), SHC1(3), SOS1(8), SRC(3) 4901533 20 20 20 1 2 6 4 4 3 1 0.0183 0.0302 1.000 8 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(2), PSMA3(1), PSMA4(2), PSMA5(3), PSMA7(3), PSMB1(1), PSMB10(2), PSMB2(2), PSMB3(1), PSMB5(3), PSMB6(1), PSMB7(1), PSMB9(1) 4919552 23 21 23 1 0 7 4 8 4 0 0.0137 0.0372 1.000 9 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 IFNG(3), IL12A(6), IL12B(2), IL18(2) 1718224 13 12 13 2 0 1 3 7 2 0 0.339 0.0375 1.000 10 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(11), PDXK(1), PNPO(1), PSAT1(2) 2699768 15 13 15 1 0 8 1 3 3 0 0.0723 0.0463 1.000 11 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(2), CAT(1), EPX(3), LPO(4), MPO(5), MTHFR(1), PRDX6(1), SHMT1(2), SHMT2(4), TPO(13) 6517697 36 30 36 3 2 9 7 9 9 0 0.00661 0.0497 1.000 12 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 LDLR(2), NR0B2(4), NR1H3(4), NR1H4(5), RXRA(2) 2992040 17 15 16 1 1 0 5 8 3 0 0.0567 0.0732 1.000 13 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 11 AKT1(2), NTRK1(5), PIK3R1(4), PLCG1(7), PRKCA(1), SHC1(3), SOS1(8) 7594929 30 26 29 2 3 6 5 4 11 1 0.0128 0.0927 1.000 14 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 12 CCNA1(3), CCNA2(4), CCND1(1), CCNE1(1), CCNE2(2), CDKN1B(5), E2F1(3), E2F4(2) 4837877 21 19 18 1 0 4 2 12 3 0 0.0243 0.102 1.000 15 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 6 AKT1(2), PIK3R1(4), PLCB1(8), PLCG1(7), PRKCA(1), VAV1(3) 6025453 25 22 24 1 0 7 1 6 11 0 0.0234 0.103 1.000 16 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), AKR1D1(3), CYP11A1(1), CYP11B1(4), CYP11B2(5), CYP17A1(3), HSD11B1(2), HSD3B1(2) 5118543 21 20 21 2 5 4 2 7 3 0 0.0533 0.106 1.000 17 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), AKR1D1(3), CYP11A1(1), CYP11B1(4), CYP11B2(5), CYP17A1(3), HSD11B1(2), HSD3B1(2) 5118543 21 20 21 2 5 4 2 7 3 0 0.0533 0.106 1.000 18 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(3), CHRNA1(4), SNAP25(3), STX1A(1) 1758176 11 11 10 2 1 3 1 4 2 0 0.486 0.111 1.000 19 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(3), LPO(4), MPO(5), PRDX6(1), TPO(13) 4778378 26 23 26 3 2 5 6 8 5 0 0.0286 0.113 1.000 20 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 FOSB(1), GRIA2(9), JUND(1), PPP1R1B(1) 2130336 12 12 11 3 2 1 4 4 1 0 0.345 0.115 1.000 21 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(4), GLS2(1), GLUD1(3), GLUD2(5) 2564143 13 12 13 1 0 5 4 2 2 0 0.0781 0.126 1.000 22 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCL11(1), CCR3(3), CD4(1), HLA-DRA(1), HLA-DRB1(1), IL1B(1), IL4(1), IL5(1), IL5RA(1), IL6(2) 2949224 13 12 13 1 1 0 1 10 1 0 0.186 0.129 1.000 23 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 14 AKT1(2), BCAR1(3), CDKN1B(5), MAPK1(3), PDK2(1), PDPK1(1), PIK3R1(4), PTK2(9), SHC1(3), SOS1(8) 9466625 39 30 38 0 2 9 6 8 13 1 1.97e-05 0.130 1.000 24 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ2(2), COQ3(1), COQ5(1), COQ6(4), COQ7(1) 2441218 9 9 9 1 1 1 2 3 2 0 0.285 0.169 1.000 25 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 GSTZ1(2), HGD(4) 1238975 6 6 6 0 0 1 0 4 1 0 0.364 0.175 1.000 26 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(2) 280438 2 2 2 0 0 0 0 1 1 0 0.858 0.188 1.000 27 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(1), PLCG1(7), PRKCA(1), PTK2B(5) 3741191 14 14 13 1 0 5 0 4 5 0 0.259 0.191 1.000 28 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 14 AKT1(2), IGF1R(11), IRS1(3), MAPK1(3), PIK3R1(4), RAF1(2), SHC1(3), SOS1(8) 9334515 36 30 36 2 3 6 8 9 9 1 0.00241 0.213 1.000 29 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(2), ACOX3(1), PLA2G12B(1), PLA2G2D(1), PLA2G2F(5), PLA2G3(7), PLA2G4A(8), PLA2G6(3) 6067489 28 25 26 3 2 3 3 13 7 0 0.0429 0.219 1.000 30 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 BCL2(1), CASP3(3), CASP8(1), CFL1(1), CFLAR(2) 2141634 8 7 8 1 0 2 1 2 3 0 0.390 0.220 1.000 31 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(3), CS(4), FH(3), IDH2(4), MDH1(1), OGDH(1), SDHA(2), SUCLA2(2) 5334258 20 18 20 2 1 4 2 6 7 0 0.115 0.223 1.000 32 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 19 CCNA1(3), CCNB1(2), CCND1(1), CCND2(3), CCNE1(1), CCNH(1), CDK6(1), CDKN1B(5), CDKN2B(1), CDKN2C(2), E2F1(3), RBL1(4), TFDP1(2) 7628055 29 27 28 2 1 5 5 11 7 0 0.00912 0.246 1.000 33 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 MYC(2), SP1(2), SP3(3), WT1(6) 3569199 13 13 13 2 2 2 3 4 2 0 0.197 0.256 1.000 34 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD4(1), CD80(4), HLA-DRA(1), HLA-DRB1(1), IL10(1), IL4(1) 2204585 9 9 9 2 0 2 1 5 1 0 0.480 0.260 1.000 35 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 13 AKT1(2), AKT2(3), AKT3(2), MAP2K2(2), NGFR(3), NTRK1(5), PIK3CD(5), SHC1(3), SOS1(8) 8086842 33 31 33 4 4 10 6 5 7 1 0.0366 0.274 1.000 36 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL11(1), CCR3(3), HLA-DRA(1), HLA-DRB1(1), IL5(1) 1633362 7 7 7 0 1 0 0 6 0 0 0.214 0.313 1.000 37 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 14 AKT1(2), AKT2(3), AKT3(2), BPNT1(2), MAPK1(3), PDK1(1), PIK3CD(5), PTK2B(5), RBL2(11), SHC1(3), SOS1(8) 9715167 45 41 45 5 3 13 7 9 12 1 0.0184 0.314 1.000 38 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(6), CAPN1(2), CAPNS1(1), CSNK1A1(2), GSK3B(3), MAPT(6), PPP2CA(2) 5532449 22 21 22 1 1 8 0 6 7 0 0.0335 0.320 1.000 39 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 11 CCNE1(1), CDKN1B(5), CKS1B(2), CUL1(2), E2F1(3), SKP2(1), TFDP1(2) 3835157 16 15 15 2 0 1 3 5 7 0 0.210 0.321 1.000 40 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDK(2), CBS(3), CTH(2), MUT(4) 2794156 11 10 11 1 1 4 0 2 4 0 0.257 0.331 1.000 41 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(2), LPL(1), NR3C1(3), PPARG(1), RXRA(2), TNF(1) 3219049 10 10 9 1 0 0 2 5 3 0 0.381 0.332 1.000 42 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 17 CSNK2A1(2), FOS(1), JUN(2), MAPK8(1), NGFR(3), PIK3R1(4), PLCG1(7), RAF1(2), SHC1(3), SOS1(8) 9564697 33 29 32 2 2 6 5 7 12 1 0.00863 0.334 1.000 43 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(2), PSMA3(1), PSMA4(2), PSMA5(3), PSMA7(3), PSMB1(1), PSMB2(2), PSMB3(1), PSMB5(3), PSMB6(1), PSMB7(1), PSMC2(2), PSMD1(7), PSMD11(1), PSMD12(7), PSMD13(2), PSMD2(2), PSMD6(1) 9003610 42 35 42 5 1 14 5 15 7 0 0.0163 0.343 1.000 44 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(1), ASL(1), CPS1(12), GLS(4), GLUD1(3) 4373737 21 18 21 4 1 8 3 4 5 0 0.232 0.346 1.000 45 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(5), ERBB4(11), NRG2(1), NRG3(3), PRKCA(1), PSEN1(2) 5099442 23 22 22 4 1 4 1 14 3 0 0.318 0.363 1.000 46 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 6 ATM(9), ATR(15), CDC25C(3), CHEK1(5), CHEK2(5) 8369196 37 32 37 4 3 3 2 19 9 1 0.144 0.396 1.000 47 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 ATP6V0C(2), GGT1(1), SHMT1(2), SHMT2(4) 2446983 9 9 9 0 1 4 0 2 2 0 0.0923 0.400 1.000 48 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(1), CYP11A1(1), CYP11B2(5), CYP17A1(3), HSD11B1(2), HSD3B1(2) 3872882 14 13 14 2 4 2 1 4 3 0 0.195 0.402 1.000 49 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(9), ARHGAP5(3), CASP10(2), CASP3(3), CASP8(1), CASP9(1), GZMB(2), JUN(2), PRF1(4) 7106840 27 23 27 2 1 10 2 7 7 0 0.0410 0.406 1.000 50 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(1), RAB1A(2), RAB27A(1), RAB4A(2), RAB6A(2), RAB9A(1) 2410361 9 8 9 1 0 3 1 2 3 0 0.400 0.436 1.000 51 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 5 NFYA(2), NFYB(1), NFYC(2), SP1(2), SP3(3) 2766602 10 10 10 2 0 1 2 4 3 0 0.580 0.439 1.000 52 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 12 AKT1(2), CHRNB1(2), CHRNG(1), MUSK(6), PIK3R1(4), PTK2(9), PTK2B(5), SRC(3), TERT(2) 8346267 34 27 34 4 0 13 3 9 9 0 0.0482 0.445 1.000 53 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(2), CSF1(2), IL6(2), LDLR(2), LPL(1) 2959650 9 9 9 1 1 1 1 5 1 0 0.293 0.460 1.000 54 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 8 ACO1(6), ACO2(3), FH(3), IDH2(4), MDH1(1), SDHB(1), SUCLA2(2) 4554533 20 19 20 4 1 4 3 7 5 0 0.407 0.470 1.000 55 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(2), GNAS(10), GNB1(2), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), PRKCA(1) 5670295 23 21 20 3 6 6 2 4 5 0 0.157 0.479 1.000 56 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 8 GABRA1(5), GABRA2(7), GABRA3(1), GABRA4(6), GABRA5(4), GABRA6(7) 3673000 30 26 27 8 0 5 1 15 9 0 0.718 0.485 1.000 57 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(1), CAMK1G(2), HDAC9(8), MEF2A(6), MEF2C(1), MEF2D(3), MYOD1(1) 4925385 22 21 22 4 0 4 2 13 3 0 0.268 0.490 1.000 58 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 19 CSNK2A1(2), FOS(1), IGF1R(11), IRS1(3), JUN(2), MAPK8(1), PIK3R1(4), PTPN11(4), RAF1(2), RASA1(10), SHC1(3), SOS1(8), SRF(1) 12736457 52 41 52 6 3 10 9 13 16 1 0.0127 0.492 1.000 59 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 11 CREB1(1), FOS(1), JUN(2), MAPK1(3), MAPK14(3), MAPK8(1), PRKCA(1) 3852689 12 12 12 0 1 2 3 2 4 0 0.0303 0.508 1.000 60 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 42 AKT1(2), AKT2(3), AKT3(2), CAB39(2), DDIT4(1), EIF4B(1), FIGF(1), HIF1A(3), INS(1), MAPK1(3), PDPK1(1), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIK3R1(4), PIK3R2(4), PIK3R3(2), PIK3R5(1), PRKAA1(4), RHEB(1), RICTOR(8), RPS6(2), RPS6KA1(1), RPS6KA2(5), RPS6KA6(8), RPS6KB1(2), RPS6KB2(4), STK11(1), TSC1(8), TSC2(12), ULK1(3), ULK2(5), ULK3(1), VEGFA(1), VEGFC(6) 28758861 116 81 112 9 7 29 12 29 39 0 5.18e-06 0.508 1.000 61 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(4), AGT(1), AGTR1(2), BDKRB2(3), KNG1(3), NOS3(9) 5740674 22 20 21 3 2 6 2 7 5 0 0.129 0.541 1.000 62 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 ECHS1(2), EHHADH(10), HADHA(3), SDS(2) 2746271 17 9 17 4 0 3 4 6 4 0 0.454 0.554 1.000 63 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C9(3) 1120947 3 3 3 0 0 2 0 1 0 0 0.415 0.560 1.000 64 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(1), NRF1(1), UBE2C(1), UBE2D1(1), UBE2D2(1), UBE2D3(4), UBE2E1(1), UBE2J1(3), UBE2J2(2), UBE2L3(1), UBE2N(4), UBE3A(1) 5920459 21 18 21 2 0 4 4 6 7 0 0.112 0.570 1.000 65 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(1), ARG1(1), GLS(4), GLUD1(3), OAT(2), PRODH(1) 3381489 12 10 12 0 0 5 2 2 3 0 0.0467 0.572 1.000 66 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(1), APAF1(9), BCL2(1), CASP3(3), CASP9(1), DAXX(1), FAS(3), HSPB1(1), HSPB2(1), MAPKAPK2(1), MAPKAPK3(1), TNF(1) 6278515 24 22 24 4 0 13 2 4 5 0 0.139 0.575 1.000 67 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 16 CD3G(1), CD80(4), CD86(2), CTLA4(1), HLA-DRA(1), HLA-DRB1(1), ITK(1), LCK(4), PIK3R1(4), PTPN11(4) 5914485 23 19 23 3 0 6 1 10 6 0 0.179 0.580 1.000 68 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(3), CD36(3), FOS(1), FYN(1), JUN(2), MAPK14(3), THBS1(6) 3989581 19 18 19 4 3 1 4 7 4 0 0.376 0.583 1.000 69 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(7), DYRK1B(2), GLI2(12), GLI3(11), GSK3B(3), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), SHH(1), SMO(1), SUFU(3) 9592315 48 43 47 8 7 8 1 18 14 0 0.0793 0.597 1.000 70 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(1), PGLYRP2(1) 1007741 2 2 2 0 0 1 0 0 1 0 0.717 0.598 1.000 71 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 20 CSNK2A1(2), FOS(1), INS(1), INSR(4), IRS1(3), JUN(2), MAPK8(1), PIK3R1(4), PTPN11(4), RAF1(2), RASA1(10), SHC1(3), SLC2A4(2), SOS1(8), SRF(1) 13158957 48 41 48 6 3 9 9 11 15 1 0.0173 0.600 1.000 72 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP2E1(4), NR1I3(2), PTGS1(2), PTGS2(3) 2927653 11 11 11 3 2 2 0 4 3 0 0.694 0.611 1.000 73 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(1), NFKB1(3), NFKBIA(2), PLCB1(8), PRKCA(1), RELA(4) 4678537 19 18 19 4 0 5 2 7 5 0 0.455 0.616 1.000 74 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA10(1), NDUFA5(2), NDUFA8(1), NDUFB5(1), NDUFB6(1), NDUFB7(2), NDUFS1(2), NDUFS2(2), NDUFV2(2) 3999223 14 14 14 2 0 3 2 9 0 0 0.219 0.620 1.000 75 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(1), CD3G(1), GZMB(2), HLA-A(3), ICAM1(1), ITGAL(5), ITGB2(8), PRF1(4) 4813374 25 22 24 4 2 8 0 9 6 0 0.281 0.622 1.000 76 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 10 AKT1(2), IL2RG(1), IL4(1), IL4R(1), IRS1(3), JAK3(7), RPS6KB1(2), SHC1(3), STAT6(5) 7002331 25 21 24 2 5 4 3 7 6 0 0.0386 0.623 1.000 77 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD4(1), HLA-DRA(1), HLA-DRB1(1) 1312979 3 3 3 1 0 0 0 3 0 0 0.860 0.626 1.000 78 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(3), HLCS(2), SPCS3(2) 1757643 7 5 7 2 0 2 2 2 1 0 0.640 0.632 1.000 79 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNB1(2), IFNG(3), IL10(1), IL12A(6), IL12B(2), IL16(7), IL18(2), IL4(1), IL5(1), IL6(2), TNF(1) 5551349 28 26 27 6 0 5 6 14 3 0 0.237 0.642 1.000 80 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(1), ACTN1(4), ACTN2(6), BCAR1(3), BCR(2), CAPN1(2), CAPNS1(1), CAV1(1), CSK(1), FYN(1), ITGA1(5), JUN(2), MAP2K2(2), MAPK1(3), MAPK8(1), PPP1R12B(4), PTK2(9), PXN(2), RAF1(2), RAP1A(2), ROCK1(6), SHC1(3), SOS1(8), SRC(3), TLN1(10), VCL(3), ZYX(2) 26968140 89 65 89 3 6 26 13 24 19 1 8.17e-08 0.654 1.000 81 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 19 AKT1(2), APAF1(9), ATM(9), BAX(3), BCL2(1), CASP3(3), CASP6(2), CASP9(1), PRKCA(1), PTK2(9), PXN(2), STAT1(5), TLN1(10) 14808116 57 48 56 6 5 18 3 19 12 0 0.00454 0.673 1.000 82 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(1), TPI1(1) 934726 2 2 2 0 0 0 0 1 1 0 0.564 0.680 1.000 83 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 CLOCK(1), CRY1(1), CRY2(1), CSNK1E(3), PER1(6) 4818668 12 11 12 2 0 5 1 5 0 1 0.355 0.682 1.000 84 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(3), GNAQ(1), JUN(2), MAP2K2(2), MAP2K3(2), MAP2K4(4), MAP3K1(3), MAPK1(3), MAPK14(3), MAPK8(1), PAK1(3), PLCG1(7), PRKCA(1), PTK2B(5), RAF1(2), SHC1(3), SOS1(8), SRC(3), SYT1(2) 16100120 58 52 57 6 3 12 7 20 15 1 0.0135 0.682 1.000 85 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH1A3(2), ALDH3B1(1), ALDH3B2(1), AOC2(2), AOC3(1), DDC(2), EPX(3), HPD(2), LPO(4), MAOA(1), MAOB(8), MPO(5), PRDX1(1), PRDX2(2), PRDX6(1), TAT(3), TPO(13) 12507820 52 44 52 5 3 11 7 16 15 0 0.00551 0.682 1.000 86 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(1), FDPS(2), HMGCR(6), IDI1(1), LSS(5), MVD(3), MVK(2), NQO1(2), PMVK(3), SQLE(1) 6311359 26 21 26 4 2 6 5 8 4 1 0.134 0.705 1.000 87 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 DHCR7(1), FDPS(2), HMGCR(6), HMGCS1(2), IDI1(1), LSS(5), MVD(3), MVK(2), NSDHL(1), PMVK(3), SQLE(1) 7496642 27 22 27 4 2 7 5 7 5 1 0.121 0.714 1.000 88 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 8 CCNA1(3), CCNE1(1), CDC34(1), CUL1(2), E2F1(3), SKP2(1), TFDP1(2) 3893220 13 11 13 2 0 2 3 5 3 0 0.386 0.726 1.000 89 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 B3GNT1(1), FUT1(4), FUT9(4), GCNT2(1) 3499754 10 9 10 1 1 0 1 7 1 0 0.232 0.728 1.000 90 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 DHRS1(1), DHRS3(1), DHRS7(1), HEMK1(3), LCMT2(3), METTL2B(5), METTL6(3), PRMT2(1), PRMT3(1), PRMT5(2), PRMT6(3), PRMT7(1), PRMT8(3), WBSCR22(2) 8364562 30 29 30 5 5 7 4 10 3 1 0.134 0.734 1.000 91 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 12 ARF1(1), CCND1(1), CDKN1B(5), CFL1(1), E2F1(3), MDM2(1) 3790629 12 12 11 2 0 1 0 7 4 0 0.459 0.737 1.000 92 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(2), TAT(3), TYR(5) 2615122 10 10 10 3 0 2 2 3 3 0 0.619 0.741 1.000 93 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 12 ACTN1(4), ACTN2(6), BCAR1(3), CSK(1), CTNNA1(3), CTNNA2(10), PTK2(9), PXN(2), SRC(3), VCL(3) 10111890 44 36 44 5 2 10 4 19 9 0 0.0350 0.741 1.000 94 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(2), POLR2A(7), POLR2B(6), POLR2G(2), POLR2H(1), POLR2I(2), POLRMT(1) 7596124 21 18 21 1 1 5 2 7 6 0 0.0324 0.748 1.000 95 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 6 CDC25B(2), CHEK1(5), NEK1(1), WEE1(2) 4158412 10 10 10 0 1 1 2 1 5 0 0.106 0.749 1.000 96 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 DCN(2), FMOD(1), KERA(1), LUM(5) 1999539 9 9 9 3 0 3 0 4 2 0 0.776 0.753 1.000 97 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(1), GGT1(1), SHMT1(2), SHMT2(4) 3246244 8 8 8 1 1 4 1 1 1 0 0.220 0.755 1.000 98 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(5), GNAS(10), GNB1(2), PRKACA(2) 3834275 19 18 16 4 6 4 1 6 2 0 0.451 0.758 1.000 99 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 12 AKT1(2), CAT(1), GH1(1), GHR(3), IGF1R(11), PIK3R1(4), SHC1(3) 6195872 25 20 25 4 3 4 3 6 9 0 0.135 0.773 1.000 100 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 10 ADAM17(5), APC(12), BTRC(5), DLL1(2), DVL1(3), FZD1(2), GSK3B(3), NOTCH1(7), PSEN1(2), WNT1(2) 10720675 43 41 43 8 5 11 5 15 6 1 0.0785 0.777 1.000 101 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(2), PSMA3(1), PSMA4(2), PSMA5(3), PSMA7(3), PSMB1(1), PSMB2(2), PSMB3(1), PSMB5(3), PSMB6(1), PSMB7(1), PSMD14(1), RPN1(1), RPN2(2), UBE3A(1) 7449521 25 22 25 3 0 10 3 8 4 0 0.0742 0.787 1.000 102 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(2), CDC25B(2), CDC25C(3), CSK(1), PRKCA(1), PTPRA(4), SRC(3) 5258311 16 16 16 3 0 2 2 7 5 0 0.385 0.791 1.000 103 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(2), ACAT2(5), ACYP1(1), ECHS1(2), EHHADH(10), GCDH(1), HADHA(3), SDHB(1), SDS(2) 4383370 27 18 27 7 0 5 6 9 7 0 0.472 0.799 1.000 104 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(1), SLPI(1) 922839 2 2 2 2 0 0 1 0 1 0 0.962 0.801 1.000 105 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(3), CPOX(1), FECH(1), HMBS(4), PPOX(3) 4427944 12 12 12 2 1 1 1 2 7 0 0.384 0.805 1.000 106 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(2), F2R(1), F2RL3(1), GNAI1(4), GNB1(2), ITGA1(5), MAPK1(3), PLA2G4A(8), PLCB1(8), PRKCA(1), PTGS1(2), PTK2(9), RAF1(2), SRC(3), SYK(1) 13732862 52 46 52 7 1 18 5 17 11 0 0.0165 0.809 1.000 107 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 19 CSNK2A1(2), FOS(1), IL6(2), IL6R(3), JAK2(4), JAK3(7), JUN(2), PTPN11(4), RAF1(2), SHC1(3), SOS1(8), SRF(1), STAT3(4) 11346266 43 33 42 5 5 9 9 13 6 1 0.0136 0.809 1.000 108 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 TAT(3) 1466952 3 3 3 2 0 1 0 0 2 0 0.946 0.813 1.000 109 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 32 AKT1(2), BCL2(1), CBL(4), CFLAR(2), E2F1(3), FOS(1), IL2RA(1), IL2RB(2), IL2RG(1), IRS1(3), JAK3(7), MAPK1(3), MYC(2), NMI(2), PIK3R1(4), PTPN6(2), RAF1(2), RPS6KB1(2), SHC1(3), SOCS3(1), SOS1(8), STAT5A(2), STAT5B(1), SYK(1) 17962566 60 53 59 7 8 10 11 18 12 1 0.00377 0.815 1.000 110 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(2), ADH1B(3), ADH4(3), ADH6(1), ADH7(1), ADHFE1(2) 3124428 12 12 12 3 0 1 2 4 5 0 0.687 0.821 1.000 111 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 19 AKT1(2), EIF4A2(3), EIF4B(1), EIF4G1(7), EIF4G2(4), EIF4G3(6), MKNK1(2), PDK2(1), PDPK1(1), PIK3R1(4), PPP2CA(2), RPS6(2), RPS6KB1(2), TSC1(8), TSC2(12) 14192041 57 44 54 8 1 13 7 10 25 1 0.0311 0.823 1.000 112 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 25 ADCY1(5), AKT1(2), CAMK2A(6), CAMK2B(2), CAMK2G(3), CREB1(1), GNAS(10), MAPK1(3), MAPK14(3), PIK3R1(4), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), PRKCA(1), RPS6KA1(1), RPS6KA5(5), SOS1(8) 15534627 62 49 58 7 10 15 7 13 16 1 0.00582 0.830 1.000 113 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(1), RANBP2(11), RANGAP1(2) 4604493 14 13 13 3 1 3 3 5 2 0 0.326 0.830 1.000 114 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3G(1) 647938 1 1 1 0 0 1 0 0 0 0 0.700 0.836 1.000 115 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(4), CR1(9), CR2(9), HLA-DRA(1), HLA-DRB1(1), ICAM1(1), ITGAL(5), ITGB2(8), PTPRC(8) 9529633 46 41 45 9 1 13 8 17 7 0 0.115 0.841 1.000 116 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD3G(1), CD8A(1), ICAM1(1), ITGAL(5), ITGB2(8), PTPRC(8), THY1(1) 5907583 25 22 24 4 1 11 4 6 3 0 0.128 0.855 1.000 117 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 SUCLA2(2) 1201148 2 2 2 1 0 0 0 0 2 0 1.000 0.859 1.000 118 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(2), FOS(1), JUN(2), MAPK1(3), MYC(2), NFKB1(3), NFKBIA(2), PLCB1(8), PRKCA(1), RAF1(2), RELA(4), TNF(1) 8646820 31 30 31 5 1 8 4 12 6 0 0.149 0.862 1.000 119 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(1), CD8A(1), CSF1(2), IL4(1), IL5(1), IL6(2), IL7(1) 3557060 9 9 9 2 0 2 1 5 1 0 0.552 0.865 1.000 120 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 24 CSNK2A1(2), FOS(1), JUN(2), MAP2K4(4), MAP3K1(3), MAPK8(1), PDGFA(2), PDGFRA(5), PIK3R1(4), PLCG1(7), PRKCA(1), RAF1(2), RASA1(10), SHC1(3), SOS1(8), SRF(1), STAT1(5), STAT3(4), STAT5A(2) 17247433 67 52 65 9 2 14 8 19 23 1 0.0368 0.870 1.000 121 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDPS(2), GGPS1(1), IDI1(1), IDI2(1), SQLE(1) 2467083 6 6 6 0 0 1 2 1 2 0 0.230 0.875 1.000 122 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDPS(2), IDI1(1), SQLE(1) 1871733 4 4 4 0 0 1 1 1 1 0 0.366 0.875 1.000 123 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(8), ABCB11(2), ABCB4(5), ABCC1(3), ABCC3(5), GSTP1(2) 8136463 25 24 25 4 1 5 4 10 5 0 0.151 0.877 1.000 124 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 16 ADRB2(3), AKT1(2), ANXA1(1), GNAS(10), GNB1(2), NFKB1(3), NOS3(9), NR3C1(3), PIK3R1(4), RELA(4), SYT1(2) 9164224 43 37 39 8 7 9 3 13 11 0 0.255 0.877 1.000 125 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(2), CSF1R(1), DDX20(3), E2F1(3), E2F4(2), ETS1(2), ETS2(1), ETV3(4), FOS(1), HDAC2(3), HDAC5(4), JUN(2), NCOR2(14), RBL1(4), RBL2(11), SIN3A(3), SIN3B(3) 15429560 63 53 61 9 8 9 10 21 15 0 0.0229 0.887 1.000 126 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD3G(1), CD4(1), CD58(1), CD8A(1), IL6(2), KITLG(2) 3551152 8 8 8 2 0 3 1 2 2 0 0.599 0.889 1.000 127 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(3), F2(2), F2R(1), F3(1), F5(7), FGA(12), FGB(3), PROC(2), SERPINC1(2), TFPI(2) 9301489 35 33 34 5 1 9 6 11 8 0 0.0662 0.898 1.000 128 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 22 BCAR1(3), CXCL12(1), CXCR4(2), GNAI1(4), GNAQ(1), GNB1(2), MAPK1(3), NFKB1(3), PIK3C2G(7), PIK3R1(4), PLCG1(7), PRKCA(1), PTK2(9), PTK2B(5), PXN(2), RAF1(2), RELA(4) 14728396 60 49 59 8 0 19 4 21 16 0 0.0362 0.900 1.000 129 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(4), SDHA(2), SDHB(1) 3652134 7 6 7 0 0 1 1 1 4 0 0.136 0.904 1.000 130 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 13 APAF1(9), ATM(9), BAX(3), BCL2(1), CCND1(1), CCNE1(1), E2F1(3), MDM2(1), TIMP3(1) 8510655 29 28 28 5 3 8 0 15 3 0 0.168 0.909 1.000 131 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(9), CDC25B(2), CDC25C(3), CHEK1(5), MYT1(2), WEE1(2) 7807729 23 22 23 4 2 2 2 10 7 0 0.340 0.921 1.000 132 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC2(2), AOC3(1), CES1(3) 3419440 6 6 6 1 1 1 1 2 1 0 0.353 0.923 1.000 133 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPL13(2), MRPS7(1), RPL10A(2), RPL11(3), RPL13(2), RPL18(1), RPL18A(3), RPL19(1), RPL21(1), RPL23A(1), RPL27(1), RPL28(1), RPL3(3), RPL35A(1), RPL36A(1), RPL37(1), RPL8(1), RPL9(1), RPS10(1), RPS13(1), RPS2(1), RPS23(1), RPS27(1), RPS3(2), RPS3A(2), RPS4Y1(1), RPS6(2), RPS7(1), RPS9(1) 12138737 41 34 40 5 5 14 4 10 8 0 0.0367 0.932 1.000 134 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(2), ATP6V0A1(6), ATP6V0A4(3), ATP6V0C(2), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1D(4), ATP6V1E1(1), ATP6V1F(2), ATP6V1H(1), SHMT1(2) 8520430 30 29 29 5 0 8 2 12 8 0 0.263 0.933 1.000 135 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(2), ATP6V0A1(6), ATP6V0A4(3), ATP6V0C(2), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1D(4), ATP6V1E1(1), ATP6V1F(2), ATP6V1H(1), SHMT1(2) 8520430 30 29 29 5 0 8 2 12 8 0 0.263 0.933 1.000 136 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(2), ATP6V0A1(6), ATP6V0A4(3), ATP6V0C(2), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1D(4), ATP6V1E1(1), ATP6V1F(2), ATP6V1H(1), SHMT1(2) 8520430 30 29 29 5 0 8 2 12 8 0 0.263 0.933 1.000 137 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(2), ACADM(1), ACAT1(2), ECHS1(2), HADHA(3) 3092657 10 8 10 4 0 3 0 3 4 0 0.872 0.933 1.000 138 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(2), AASS(5) 2623568 7 7 7 2 0 2 2 1 2 0 0.695 0.934 1.000 139 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(2), FUCA1(1), FUCA2(1), GLB1(3), HEXA(3), HEXB(1), LCT(6), MAN2C1(5), MANBA(1), NEU1(2), NEU2(4), NEU3(2), NEU4(2) 9607867 33 30 32 5 2 9 6 10 6 0 0.0512 0.934 1.000 140 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 6 JAK2(4), JAK3(7), MAPK1(3), STAT3(4), TYK2(1) 5518222 19 17 18 4 4 3 3 7 2 0 0.292 0.934 1.000 141 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 16 AKT1(2), CREB1(1), MAPK1(3), MAPK7(3), MEF2A(6), MEF2C(1), MEF2D(3), NTRK1(5), PIK3R1(4), PLCG1(7), RPS6KA1(1), SHC1(3) 10040742 39 33 38 6 3 8 3 13 12 0 0.154 0.935 1.000 142 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(1), ST3GAL1(1), ST3GAL2(1), ST6GALNAC2(3) 3150051 6 6 6 1 0 2 1 1 2 0 0.627 0.936 1.000 143 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3G(1), CD4(1), FYN(1), HLA-DRA(1), HLA-DRB1(1), LCK(4), PTPRC(8), ZAP70(3) 5117434 20 17 20 4 0 3 3 11 3 0 0.437 0.936 1.000 144 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 12 ABL1(2), E2F1(3), MDM2(1), MYC(2), PIK3R1(4), POLR1A(7), POLR1B(2), POLR1C(1), TBX2(2), TWIST1(2) 8451429 26 24 26 4 3 3 0 9 11 0 0.312 0.937 1.000 145 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(2), CCNH(1), CDC25B(2), CDC25C(3), SHH(1), XPO1(5) 4987515 14 13 14 3 0 1 2 7 4 0 0.504 0.940 1.000 146 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 9 BPNT1(2), PAPSS1(2), PAPSS2(1), SULT1A2(1), SULT1E1(1), SUOX(2) 4723320 9 9 9 1 0 3 3 2 1 0 0.213 0.940 1.000 147 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6AP1(2), ATP6V0A1(6), ATP6V0A4(3), ATP6V0C(2), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1D(4), ATP6V1E1(1), ATP6V1F(2), ATP6V1H(1), FDXR(1), SHMT1(2) 9059599 31 29 30 5 0 9 2 12 8 0 0.225 0.942 1.000 148 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CHPT1(1), HEMK1(3), LCMT2(3), METTL2B(5), METTL6(3), PCYT1A(3), PCYT1B(1), PRMT2(1), PRMT3(1), PRMT5(2), PRMT6(3), PRMT7(1), PRMT8(3), WBSCR22(2) 7864935 32 30 32 7 4 8 5 9 5 1 0.308 0.943 1.000 149 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(3), LCT(6), MPI(2), PGM1(1), PYGL(2), PYGM(8), TPI1(1) 7781155 23 22 23 4 2 6 5 7 3 0 0.117 0.944 1.000 150 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 7 CCNE1(1), CDC34(1), CUL1(2), E2F1(3), FBXW7(3), TFDP1(2) 3770122 12 10 12 3 0 2 3 5 2 0 0.562 0.945 1.000 151 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(3), CPO(1), FECH(1), GATA1(3), HMBS(4) 4793392 12 12 12 2 1 2 0 2 7 0 0.390 0.946 1.000 152 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 33 ACTA1(1), DOCK1(7), FOS(1), GAB1(3), HGF(7), ITGA1(5), JUN(2), MAP2K2(2), MAP4K1(1), MAPK1(3), MAPK8(1), MET(2), PAK1(3), PIK3R1(4), PTK2(9), PTK2B(5), PTPN11(4), PXN(2), RAF1(2), RAP1A(2), RASA1(10), SOS1(8), SRC(3), STAT3(4) 24032745 91 67 90 10 3 28 10 30 19 1 0.000431 0.947 1.000 153 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 21 AKT1(2), BCL2(1), BCR(2), FOS(1), JAK2(4), JUN(2), MAP2K4(4), MAP3K1(3), MAPK8(1), MYC(2), PIK3R1(4), RAF1(2), SOS1(8), STAT1(5), STAT5A(2), STAT5B(1) 14428763 44 38 44 5 2 8 6 12 15 1 0.0399 0.948 1.000 154 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(2), ACAT2(5), HMGCL(2), OXCT1(2) 1906981 11 10 10 5 0 2 1 5 3 0 0.874 0.950 1.000 155 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(7), POLR1B(2), POLR1C(1), POLR2A(7), POLR2B(6), POLR2G(2), POLR2H(1), POLR2I(2), POLR3A(3), POLR3B(2), POLR3H(1), ZNRD1(1) 12986450 35 28 35 1 2 8 2 10 13 0 0.00343 0.951 1.000 156 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 MMP14(3), MMP2(1), MMP9(3), RECK(3), TIMP1(2), TIMP3(1), TIMP4(3) 4337630 16 15 16 4 1 4 1 7 3 0 0.499 0.953 1.000 157 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 14 BPNT1(2), CHST11(2), CHST12(2), CHST13(3), PAPSS1(2), PAPSS2(1), SULT1A2(1), SULT1E1(1), SUOX(2) 6543804 16 15 16 2 1 3 3 6 3 0 0.191 0.960 1.000 158 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 19 AKT1(2), CCND1(1), CCNE1(1), CDK6(1), CDKN1B(5), E2F1(3), MAPK1(3), NFKB1(3), NFKBIA(2), PAK1(3), PIK3R1(4), RAF1(2), RELA(4), TFDP1(2) 9054146 36 29 35 6 0 6 3 15 12 0 0.210 0.961 1.000 159 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(1), EPHA4(13), EPHB1(5), FYN(1), ITGA1(5), L1CAM(7), LYN(1), SELP(1) 8792317 34 32 34 7 5 11 2 10 6 0 0.198 0.961 1.000 160 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CCL3(1), FLT3(4), IL6(2), KITLG(2), TGFB1(1), TGFB2(4), TGFB3(2) 4872769 16 16 16 4 1 5 3 4 3 0 0.441 0.961 1.000 161 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(9), BAX(3), BCL10(1), BCL2(1), CASP9(1), CES1(3) 6585107 18 16 17 4 2 10 1 2 3 0 0.196 0.962 1.000 162 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(1), ACTN1(4), ACTN2(6), CAPN1(2), CAPNS1(1), ITGA1(5), ITGB3(5), PTK2(9), PXN(2), SPTAN1(7), SRC(3), TLN1(10) 16342824 55 45 55 7 5 21 3 13 13 0 0.0224 0.962 1.000 163 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 21 CSNK2A1(2), FOS(1), JAK2(4), JUN(2), MPL(1), PIK3R1(4), PLCG1(7), PRKCA(1), RAF1(2), RASA1(10), SHC1(3), SOS1(8), STAT1(5), STAT3(4), STAT5A(2), STAT5B(1) 15686535 57 45 55 9 2 13 6 17 18 1 0.117 0.962 1.000 164 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(2), GPLD1(2), PGAP1(3), PIGA(1), PIGB(1), PIGC(2), PIGL(2), PIGM(4), PIGN(6), PIGO(2), PIGQ(3), PIGS(5), PIGV(2), PIGW(3), PIGZ(4) 13978282 42 37 42 5 4 7 3 16 12 0 0.0596 0.963 1.000 165 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(6), ESR2(1), ITPKA(1), PDE1A(2), PDE1B(2), PLCB1(8), PLCB2(3), PRL(3), TRH(2) 6309982 28 26 27 6 3 11 1 7 6 0 0.205 0.965 1.000 166 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 CBS(3), CTH(2), GGT1(1), MARS(6), MAT1A(4), PAPSS1(2), PAPSS2(1), SCLY(1) 7034688 20 18 20 3 2 6 1 7 4 0 0.239 0.965 1.000 167 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(5), EGF(6), EGFR(6), HGS(4), TF(3), TFRC(2) 7175766 26 26 25 8 0 8 1 5 12 0 0.882 0.966 1.000 168 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 21 ARHGAP5(3), DIAPH1(5), FYN(1), GSN(2), ITGA1(5), MAPK1(3), MYLK(3), PIK3R1(4), PTK2(9), PXN(2), RAF1(2), ROCK1(6), SHC1(3), SRC(3), TLN1(10) 20029317 61 47 61 5 3 14 5 21 18 0 0.00123 0.968 1.000 169 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(1), AGPAT2(2), AGPAT3(1), AGPAT4(1), AGPAT6(2), AGPS(3), CHPT1(1), ENPP2(1), ENPP6(2), PAFAH1B1(1), PAFAH1B2(1), PLA2G12B(1), PLA2G2D(1), PLA2G2F(5), PLA2G3(7), PLA2G4A(8), PLA2G6(3), PLD1(4), PLD2(3), PPAP2A(3), PPAP2B(1), PPAP2C(2) 13365847 54 40 52 9 3 8 9 17 17 0 0.0379 0.970 1.000 170 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(1), ARFGAP1(3), ARFGAP3(1), ARFGEF2(5), CLTB(1), COPA(4), GBF1(4), GPLD1(2), KDELR1(1), KDELR2(2), KDELR3(1) 9097975 25 23 25 4 1 7 3 7 7 0 0.157 0.971 1.000 171 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 EPHX2(1), HSD3B7(1), RDH11(1), RDH13(1), RDH14(1) 2643009 5 5 5 2 1 2 0 1 1 0 0.831 0.971 1.000 172 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 TGDS(1), UGDH(2) 2272848 3 3 3 1 0 2 0 0 1 0 0.779 0.972 1.000 173 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 17 ABCB1(8), AKT1(2), ATM(9), BAX(3), CPB2(2), CSNK1A1(2), HIF1A(3), IGFBP3(2), MAPK8(1), MDM2(1), NQO1(2) 11566484 35 33 33 5 3 6 2 19 5 0 0.131 0.973 1.000 174 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 18 ADCY1(5), ARHGEF1(1), F2(2), F2R(1), F2RL3(1), GNA12(1), GNA13(1), GNAI1(4), GNAQ(1), GNB1(2), MAP3K7(3), PIK3R1(4), PLCB1(8), PPP1R12B(4), PRKCA(1), PTK2B(5), ROCK1(6) 13338231 50 41 50 8 0 14 4 15 17 0 0.0976 0.973 1.000 175 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(1), ATIC(2), ATP6V0C(2), GART(4), MTHFD1(4), MTHFD1L(2), MTHFD2(2), MTHFR(1), MTR(3), SHMT1(2), SHMT2(4), TYMS(1) 10037867 28 23 27 2 0 8 1 12 7 0 0.0186 0.975 1.000 176 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CAMK1(1), CAMK1G(2), CAMK2A(6), CAMK2B(2), CAMK2G(3), CAMKK1(1), CAMKK2(3), CREB1(1), SYT1(2) 6714282 21 19 21 4 1 5 2 7 6 0 0.291 0.975 1.000 177 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(1), ALDH1A2(1) 2113739 2 2 2 1 0 0 0 2 0 0 0.888 0.976 1.000 178 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT1(1), B3GALT5(2), B3GNT5(1), FUT1(4), FUT3(2) 4027599 10 9 10 3 1 3 1 4 1 0 0.580 0.977 1.000 179 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(1), PLCD1(2), PRKCA(1), TGM2(1) 2870851 5 5 5 2 1 1 0 1 2 0 0.701 0.977 1.000 180 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(1), ACTR2(1), ARPC1A(1), ARPC1B(2), ARPC2(3), ARPC3(1), CDC42(3), WASF1(1), WASL(2) 4628812 15 15 15 4 2 7 4 1 1 0 0.297 0.978 1.000 181 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(10), CPT1A(4), LEP(2), LEPR(4), PRKAA1(4), PRKAB2(1), PRKAG2(3) 8040720 28 26 28 5 3 5 1 10 9 0 0.290 0.979 1.000 182 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(1), ALPL(1), ALPP(4), ALPPL2(2), FPGS(1) 4019923 9 9 9 3 0 1 2 4 2 0 0.764 0.981 1.000 183 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(2), ASPH(1), COPS5(1), CREB1(1), EDN1(2), EP300(11), HIF1A(3), JUN(2), LDHA(1), NOS3(9), P4HB(1) 9622891 34 29 31 5 1 10 2 14 7 0 0.141 0.981 1.000 184 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 CBS(3), CTH(2), GGT1(1), HEMK1(3), LCMT2(3), MARS(6), MAT1A(4), METTL2B(5), METTL6(3), PAPSS1(2), PAPSS2(1), PRMT2(1), PRMT3(1), PRMT5(2), PRMT6(3), PRMT7(1), PRMT8(3), SCLY(1), WBSCR22(2) 14081397 47 40 47 8 6 13 5 15 7 1 0.0915 0.982 1.000 185 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(1), AGTR1(2), ATF2(1), EGFR(6), GNAQ(1), JUN(2), MAP2K2(2), MAP2K4(4), MAP3K1(3), MAPK1(3), MAPK8(1), MEF2A(6), MEF2C(1), MEF2D(3), PAK1(3), PRKCA(1), PTK2(9), PTK2B(5), RAF1(2), SHC1(3), SOS1(8), SRC(3), SYT1(2) 19383769 72 61 71 11 2 19 8 27 15 1 0.0441 0.982 1.000 186 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 DHCR24(1), DHCR7(1), FDPS(2), GGCX(4), GGPS1(1), HMGCR(6), HSD17B7(1), IDI1(1), IDI2(1), LSS(5), MVD(3), MVK(2), NQO1(2), NSDHL(1), PMVK(3), SQLE(1), TM7SF2(2) 11056012 37 30 37 5 3 9 6 9 9 1 0.0580 0.983 1.000 187 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 GAD1(5), HDC(4), TH(1), TPH1(2) 3406519 12 11 12 4 3 2 1 2 4 0 0.626 0.984 1.000 188 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(1), FOS(1), JUN(2), OPRK1(3), POLR2A(7), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3) 7202874 22 19 21 3 0 7 1 10 4 0 0.288 0.985 1.000 189 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(1), ATIC(2), FTCD(3), GART(4), MTFMT(1), MTHFD1(4), MTHFD1L(2), MTHFD2(2), MTHFR(1), MTR(3), SHMT1(2), SHMT2(4), TYMS(1) 10833244 30 24 29 2 0 8 1 11 10 0 0.0252 0.986 1.000 190 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(2), IARS(5), LARS(1), LARS2(2), PDHA1(1), PDHA2(3), PDHB(2) 5582199 16 15 16 4 1 6 1 6 2 0 0.379 0.986 1.000 191 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 21 CSNK2A1(2), FOS(1), IL2RA(1), IL2RB(2), IL2RG(1), JAK3(7), JUN(2), LCK(4), MAPK8(1), RAF1(2), SHC1(3), SOS1(8), STAT5A(2), STAT5B(1), SYK(1) 12248788 38 31 38 5 5 7 9 11 5 1 0.0208 0.987 1.000 192 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 24 GH1(1), GHR(3), INS(1), INSR(4), IRS1(3), JAK2(4), MAPK1(3), PIK3R1(4), PLCG1(7), PRKCA(1), PTPN6(2), RAF1(2), RPS6KA1(1), SHC1(3), SLC2A4(2), SOS1(8), SRF(1), STAT5A(2), STAT5B(1) 17575838 53 47 52 8 6 8 10 13 15 1 0.0298 0.988 1.000 193 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(6), GNAS(10), GNB1(2), IGF1R(11), MAP2K2(2), MAPK1(3), MKNK1(2), MKNK2(3), MYC(2), NGFR(3), PDGFRA(5), PPP2CA(2), PTPRR(2), RAF1(2), RPS6KA1(1), RPS6KA5(5), SHC1(3), SOS1(8), SRC(3), STAT3(4) 19157889 79 65 73 11 13 16 10 29 10 1 0.0102 0.989 1.000 194 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(2), ACADM(1), ACADVL(2), ACSL1(1), ACSL3(2), CPT1A(4), CPT2(1), EHHADH(10), HADHA(3), PECR(3), SCP2(3) 9447068 32 23 32 7 1 5 5 9 12 0 0.381 0.990 1.000 195 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 24 AKT1(2), AKT2(3), AKT3(2), CISH(5), IARS(5), IL13RA1(2), IL2RG(1), IL4(1), IL4R(1), JAK2(4), JAK3(7), NR0B2(4), PPP1R13B(4), RPS6KB1(2), SERPINA4(2), SHC1(3), SOS1(8), SOS2(4), SRC(3), STAT6(5), TYK2(1) 18261574 69 56 68 10 9 19 9 17 14 1 0.0104 0.991 1.000 196 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(2), CAMP(1), DAG1(1), GNAQ(1), ITPKA(1), ITPKB(4) 3438324 10 10 10 5 2 1 1 3 3 0 0.922 0.992 1.000 197 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH9A1(1) 4505528 8 8 8 2 0 2 0 5 1 0 0.569 0.992 1.000 198 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH9A1(1) 4505528 8 8 8 2 0 2 0 5 1 0 0.569 0.992 1.000 199 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CCR5(2), CXCL12(1), CXCR4(2), FOS(1), GNAQ(1), JUN(2), MAPK14(3), MAPK8(1), PLCG1(7), PRKCA(1), PTK2B(5), SYT1(2) 7593077 28 27 27 6 1 9 2 9 7 0 0.350 0.992 1.000 200 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 29 AKT1(2), AKT2(3), AKT3(2), BCR(2), CD19(2), DAPP1(1), FLOT1(3), GAB1(3), ITPR1(15), ITPR2(11), ITPR3(11), LYN(1), NR0B2(4), PDK1(1), PHF11(3), PITX2(1), PLCG2(7), PPP1R13B(4), PREX1(16), PTPRC(8), RPS6KA1(1), RPS6KA2(5), RPS6KB1(2), SAG(2), SYK(1), VAV1(3) 28642020 114 85 112 14 14 24 13 47 16 0 0.000519 0.992 1.000 201 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 10 CISH(5), IL6(2), IL6R(3), JAK2(4), JAK3(7), PIAS3(1), PTPRU(2), REG1A(1), SRC(3), STAT3(4) 7458604 32 26 31 7 3 8 4 12 5 0 0.291 0.992 1.000 202 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 21 APC(12), BTRC(5), CCND1(1), CREBBP(6), CSNK1A1(2), CSNK2A1(2), CTBP1(1), DVL1(3), FZD1(2), GSK3B(3), MAP3K7(3), MYC(2), NLK(2), PPP2CA(2), TLE1(6), WIF1(6), WNT1(2) 15325905 60 51 59 10 2 16 3 22 16 1 0.0761 0.993 1.000 203 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(2), ENO3(1), FARS2(1), PAH(2), TAT(3) 4574562 9 9 9 6 0 1 3 0 5 0 0.934 0.993 1.000 204 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMPR1A(1), BMPR1B(2), BMPR2(5) 3457871 8 7 8 3 1 2 1 0 4 0 0.782 0.993 1.000 205 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(2), F13A1(2), F2(2), F2R(1), FGA(12), FGB(3), PLAT(2), PLG(3), SERPINB2(3), SERPINE1(1) 7484200 31 30 31 8 1 9 7 6 8 0 0.386 0.993 1.000 206 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 13 AKT1(2), CASP9(1), CHUK(8), GH1(1), GHR(3), NFKB1(3), NFKBIA(2), PDPK1(1), PIK3R1(4), PPP2CA(2), RELA(4) 7060355 31 25 31 7 1 7 4 8 11 0 0.445 0.993 1.000 207 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD3G(1), CD4(1), ICAM1(1), ITGAL(5), ITGB2(8), PTPRC(8), THY1(1) 6222513 25 22 24 5 1 10 4 7 3 0 0.252 0.993 1.000 208 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 12 BLVRA(1), HMOX1(1), IL10(1), IL10RA(3), IL10RB(2), IL6(2), STAT1(5), STAT3(4), STAT5A(2), TNF(1) 5583014 22 21 21 6 0 7 2 12 1 0 0.544 0.993 1.000 209 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(1), ADCY3(2), ADCY9(6), AK1(1), ARF1(1), ARF5(1), ATP6V0A1(6), ATP6V0A2(2), ATP6V0A4(3), ATP6V0C(2), ATP6V0D1(1), ATP6V0D2(1), ATP6V1A(2), ATP6V1C2(1), ATP6V1D(4), ATP6V1E1(1), ATP6V1F(2), ATP6V1H(1), ERO1L(1), GNAS(10), PDIA4(2), PLCG1(7), PLCG2(7), PRKCA(1), SEC61A1(2), TRIM23(1) 21063462 69 57 64 9 8 17 4 24 16 0 0.0329 0.994 1.000 210 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(2), DPYD(6), DPYS(1), ENPP1(1), ENPP3(4), PANK1(1), PANK2(2), PANK4(4), PPCS(1), UPB1(1) 7997683 23 18 23 4 2 7 4 8 2 0 0.146 0.994 1.000 211 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 5 IFNG(3), IFNGR1(3), IFNGR2(1), JAK2(4), STAT1(5) 3269155 16 14 16 6 0 4 1 7 4 0 0.857 0.994 1.000 212 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 MAP2K2(2), MAPK1(3), NGFR(3), RAF1(2) 4765427 10 10 10 3 0 2 1 5 2 0 0.679 0.995 1.000 213 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 23 ATF2(1), BCR(2), BLNK(3), FOS(1), JUN(2), LYN(1), MAP3K1(3), MAPK1(3), MAPK8IP3(2), PAPPA(5), RPS6KA1(1), SHC1(3), SOS1(8), SYK(1), VAV1(3), VAV3(8) 17388623 47 43 47 6 4 14 8 17 3 1 0.0159 0.995 1.000 214 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(2), EPOR(1), FOS(1), JAK2(4), JUN(2), MAPK8(1), PLCG1(7), PTPN6(2), RAF1(2), SHC1(3), SOS1(8), STAT5A(2), STAT5B(1) 12429490 36 30 35 5 3 7 5 11 9 1 0.117 0.996 1.000 215 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(6), ACO2(3), CS(4), HAO1(1), MDH1(1), MTHFD1(4), MTHFD1L(2), MTHFD2(2) 7139632 23 22 23 5 1 5 0 9 8 0 0.418 0.996 1.000 216 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(2), ACAT2(5), BDH1(2), BDH2(1), HMGCL(2), HMGCS1(2), HMGCS2(2), OXCT1(2) 4280853 18 16 17 6 0 4 1 7 6 0 0.783 0.996 1.000 217 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 19 B2M(1), HLA-A(3), IL18(2), KLRC1(1), KLRC3(2), KLRC4(1), LAT(1), PAK1(3), PIK3R1(4), PTK2B(5), PTPN6(2), SYK(1), VAV1(3) 9449032 29 27 29 6 1 5 2 10 11 0 0.403 0.996 1.000 218 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(1), CAMK2A(6), CAMK2B(2), CAMK2G(3), F2(2), FYN(1), GNAI1(4), GNB1(2), JAK2(4), MAP2K2(2), MAPK1(3), MAPK14(3), MAPK8(1), MAPT(6), MYLK(3), PLCG1(7), PRKCA(1), PTK2B(5), RAF1(2), SHC1(3), SOS1(8), STAT1(5), STAT3(4), STAT5A(2), SYT1(2) 23927797 82 66 80 11 5 23 9 24 20 1 0.00818 0.996 1.000 219 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(6), EGFR(6), ERBB3(8), NRG1(2), UBE2D1(1) 5717894 23 22 22 9 0 5 3 9 6 0 0.882 0.996 1.000 220 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 17 GNAQ(1), NFATC1(2), NFATC2(7), NFATC3(4), NFATC4(5), PLCG1(7), PPP3CA(3), PPP3CB(3), PRKCA(1), SP1(2), SP3(3), SYT1(2) 11503655 40 35 38 9 5 8 5 14 8 0 0.277 0.996 1.000 221 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 25 AKT1(2), AKT2(3), AKT3(2), BCL2(1), GSK3A(1), GSK3B(3), IL4R(1), IRS1(3), IRS2(2), JAK3(7), MAP4K1(1), MAPK1(3), PDK1(1), PIK3CD(5), PIK3R1(4), PPP1R13B(4), RAF1(2), SHC1(3), SOS1(8), SOS2(4), STAT6(5) 18292182 65 54 65 10 11 16 11 10 16 1 0.00928 0.996 1.000 222 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(6), CAMK2B(2), CAMK2G(3), DAG1(1), ITPKA(1), ITPKB(4), ITPR1(15), ITPR2(11), ITPR3(11), NFAT5(6), PDE6A(7), PDE6B(8), SLC6A13(4), TF(3) 20584781 82 65 81 12 9 23 3 29 18 0 0.0223 0.996 1.000 223 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(5), FHL5(2), FSHR(4), GNAS(10), XPO1(5) 5487411 26 25 23 6 6 3 2 11 4 0 0.510 0.996 1.000 224 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(1), B4GALT2(1), B4GALT3(2), B4GALT5(1), FUT8(2), ST3GAL1(1), ST3GAL2(1) 4359855 9 9 9 3 1 0 0 5 3 0 0.875 0.996 1.000 225 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(1), ALDOB(1), TPI1(1) 2185055 3 3 3 3 0 0 0 2 1 0 0.945 0.997 1.000 226 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(9), BIRC2(4), BIRC3(1), CASP10(2), CASP3(3), CASP8(1), CASP9(1), DFFB(1), GZMB(2), PRF1(4), SCAP(5), SREBF1(3), SREBF2(3) 10646841 39 33 39 9 3 10 1 9 15 1 0.518 0.997 1.000 227 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(3), ARHGEF1(1), GNA12(1), GNA13(1), GNAQ(1), GNB1(2), MYLK(3), PLCB1(8), PPP1R12B(4), PRKCA(1), ROCK1(6) 11611646 31 27 31 5 0 6 4 10 11 0 0.229 0.997 1.000 228 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 CLOCK(1), CRY1(1), CRY2(1), CSNK1E(3), NPAS2(4), NR1D1(1), PER1(6), PER2(4), PER3(5) 9679464 26 23 26 5 1 8 3 9 4 1 0.297 0.997 1.000 229 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(6), ACO2(3), CS(4), HAO1(1), MDH1(1), MTHFD1(4), MTHFD1L(2), MTHFD2(2) 7491796 23 22 23 5 1 5 0 9 8 0 0.422 0.998 1.000 230 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(1), AKR1D1(3), ARSD(3), ARSE(2), CYP11B1(4), CYP11B2(5), HSD11B1(2), HSD17B3(2), HSD17B8(1), HSD3B1(2), SRD5A1(1), STS(4), SULT1E1(1), UGT1A1(3), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A9(1), UGT2B15(1), UGT2B4(5) 15215028 48 44 48 9 4 15 5 10 14 0 0.163 0.998 1.000 231 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(6), EGFR(6), MAP3K1(3), MAPK14(3), NCOR2(14), RARA(1), RXRA(2) 9985932 35 33 32 8 7 6 6 8 8 0 0.346 0.998 1.000 232 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 ECHS1(2), EHHADH(10), HADH(1), HADHA(3), HSD17B4(1), NTAN1(2), SIRT1(2), SIRT2(2), VNN2(1) 6711713 24 14 24 6 1 6 6 7 4 0 0.311 0.998 1.000 233 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 8 CISH(5), IFNG(3), IFNGR1(3), JAK2(4), PTPRU(2), REG1A(1), STAT1(5) 5124734 23 20 23 7 0 7 2 8 6 0 0.691 0.998 1.000 234 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 24 CSNK2A1(2), EGF(6), EGFR(6), FOS(1), JUN(2), MAP2K4(4), MAP3K1(3), MAPK8(1), PIK3R1(4), PLCG1(7), PRKCA(1), RAF1(2), RASA1(10), SHC1(3), SOS1(8), SRF(1), STAT1(5), STAT3(4), STAT5A(2) 18638683 72 58 69 12 2 16 8 20 25 1 0.117 0.998 1.000 235 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH9A1(1), ECHS1(2), EHHADH(10), HADHA(3), SDS(2) 6880346 25 16 25 6 0 5 4 11 5 0 0.404 0.998 1.000 236 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 APAF1(9), BAX(3), BCL2(1), BIRC2(4), BIRC3(1), CASP3(3), CASP6(2), CASP8(1), CASP9(1), DFFB(1), DIABLO(1) 7613601 27 23 26 6 3 9 1 5 9 0 0.457 0.998 1.000 237 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(3), F13B(1), HSD17B3(2), HSD17B4(1), HSD17B7(1), HSD3B1(2) 4531073 10 10 10 6 2 2 0 2 4 0 0.882 0.998 1.000 238 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ALDH1A3(2), ALDH3B1(1), ALDH3B2(1), AOC2(2), AOC3(1), DDC(2), EPX(3), ESCO1(2), ESCO2(3), HPD(2), LPO(4), MAOA(1), MAOB(8), MPO(5), NAT6(1), PNPLA3(1), PRDX6(1), SH3GLB1(2), TAT(3), TPO(13) 19185495 58 47 58 8 3 14 8 19 14 0 0.0102 0.998 1.000 239 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(1), FUT1(4), FUT9(4), GBGT1(3), GLA(1), HEXA(3), HEXB(1), ST3GAL1(1), ST3GAL2(1) 5613326 19 18 19 7 2 0 0 11 6 0 0.851 0.998 1.000 240 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(5), DLL1(2), FURIN(5), NOTCH1(7), PSEN1(2) 5601243 21 21 21 6 5 4 4 6 2 0 0.275 0.999 1.000 241 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(2), AASDH(4), AASS(5) 3851709 11 11 11 4 0 3 2 4 2 0 0.787 0.999 1.000 242 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(3), APOBEC3A(1), APOBEC3B(2), APOBEC3G(1), APOBEC4(2) 4083245 9 9 9 3 0 0 0 5 4 0 0.922 0.999 1.000 243 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(1), DCXR(1), GUSB(8), UCHL1(1), UCHL3(2), UGDH(2), UGT1A1(3), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A9(1), UGT2B15(1), UGT2B4(5) 9672739 32 25 31 8 0 7 1 7 17 0 0.808 0.999 1.000 244 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(1), CDC42(3), CREB1(1), DAXX(1), HMGN1(1), HSPB1(1), HSPB2(1), MAP2K4(4), MAP2K6(2), MAP3K1(3), MAP3K5(1), MAP3K7(3), MAP3K9(3), MAPK14(3), MAPKAPK2(1), MAPKAPK5(3), MEF2A(6), MEF2C(1), MEF2D(3), MKNK1(2), MYC(2), PLA2G4A(8), RIPK1(4), RPS6KA5(5), SHC1(3), STAT1(5), TGFB1(1), TGFB2(4), TGFB3(2), TGFBR1(1) 21268047 79 63 78 13 8 16 9 29 17 0 0.0367 0.999 1.000 245 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(3), EIF2AK4(7), EIF2B5(1), EIF2S2(1), EIF2S3(1), EIF5(1), GSK3B(3), PPP1CA(2) 6486048 19 19 19 5 0 10 0 3 6 0 0.345 0.999 1.000 246 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 APEX1(3), CREBBP(6), DFFB(1), GZMA(3), GZMB(2), HMGB2(1), NME1(2), PRF1(4) 6005111 22 22 22 9 2 4 2 7 7 0 0.864 0.999 1.000 247 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 13 ACTR2(1), ARPC1A(1), ARPC1B(2), ARPC2(3), ARPC3(1), CDC42(3), PAK1(3), PDGFRA(5), PIK3R1(4), WASL(2) 6342551 25 22 25 6 2 8 5 4 6 0 0.324 0.999 1.000 248 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(5), CHAT(4), CHKA(1), PCYT1A(3), PDHA1(1), PDHA2(3) 3884724 17 16 17 7 2 2 1 9 3 0 0.767 0.999 1.000 249 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 8 CISH(5), JAK2(4), JAK3(7), PIAS3(1), PTPRU(2), REG1A(1) 6660306 20 17 20 5 3 5 3 5 4 0 0.396 0.999 1.000 250 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(1), FARSA(2), FARSB(1), PAH(2), TAT(3) 4863921 9 9 9 6 0 2 3 0 4 0 0.970 0.999 1.000 251 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(2), LDLR(2), MBTPS1(4), MBTPS2(1), SCAP(5), SREBF1(3), SREBF2(3) 7113483 20 18 20 5 3 3 2 4 7 1 0.404 0.999 1.000 252 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(2), SRP54(1), SRP68(1), SRP72(3), SRPR(2) 4184650 9 6 9 2 1 3 0 1 4 0 0.763 0.999 1.000 253 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(1), B3GALNT1(1), B3GALT5(2), FUT1(4), FUT9(4), GBGT1(3), GLA(1), HEXA(3), HEXB(1), ST3GAL1(1), ST3GAL2(1) 5946789 22 21 22 7 2 2 0 12 6 0 0.760 0.999 1.000 254 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(11), CD38(3), ENPP1(1), ENPP3(4), NMNAT1(2), NNT(4), NT5E(1), NT5M(2) 8252110 28 24 27 7 0 15 3 6 4 0 0.323 0.999 1.000 255 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 14 CNR1(3), CNR2(1), DNMT1(2), MTNR1A(2), MTNR1B(3), PTGER1(1), PTGER2(3), PTGER4(1), PTGFR(2), PTGIR(2) 6573798 20 19 20 5 1 5 4 9 1 0 0.267 0.999 1.000 256 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT1(4), FUT3(2), FUT5(1) 2859652 7 7 7 4 2 0 1 3 1 0 0.878 0.999 1.000 257 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(1), ADORA2A(2), ADORA2B(1), ADORA3(2), LTB4R(1), P2RY1(4), P2RY2(1), P2RY6(1) 3179701 13 13 13 6 0 1 2 8 2 0 0.843 0.999 1.000 258 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(5), GNAS(10), GNB1(2), PPP2CA(2), PRKAA1(4), PRKAB2(1), PRKACB(2), PRKACG(2), PRKAG2(3), PRKAR1B(1), PRKAR2B(3) 8865671 35 31 32 8 7 8 1 13 6 0 0.451 0.999 1.000 259 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 10 ACLY(3), ACO1(6), ACO2(3), ACSS1(2), ACSS2(1), FH(3), IDH2(4), MDH1(1), SUCLA2(2) 7016875 25 24 25 7 2 4 5 7 7 0 0.593 0.999 1.000 260 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 17 AKT1(2), EIF2B5(1), EIF2S2(1), EIF2S3(1), GSK3B(3), IGF1R(11), INPPL1(1), PDK2(1), PDPK1(1), PIK3R1(4), PPP2CA(2), RPS6(2), RPS6KB1(2) 9784107 32 25 31 6 1 7 2 10 12 0 0.228 0.999 1.000 261 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 67 AKT1(2), AKT2(3), AKT3(2), CASP9(1), CDC42(3), KDR(7), MAP2K2(2), MAPK1(3), MAPK11(1), MAPK12(1), MAPK14(3), MAPKAPK2(1), MAPKAPK3(1), NFAT5(6), NFATC1(2), NFATC2(7), NFATC3(4), NFATC4(5), NOS3(9), NRAS(3), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIK3R1(4), PIK3R2(4), PIK3R3(2), PIK3R5(1), PLA2G12B(1), PLA2G2D(1), PLA2G2F(5), PLA2G3(7), PLA2G4A(8), PLA2G6(3), PLCG1(7), PLCG2(7), PPP3CA(3), PPP3CB(3), PRKCA(1), PRKCG(4), PTGS2(3), PTK2(9), PXN(2), RAC3(1), RAF1(2), SH2D2A(2), SPHK1(7), SPHK2(3), SRC(3), VEGFA(1) 40160434 173 109 166 27 17 38 17 51 50 0 0.00115 0.999 1.000 262 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(1), ECHS1(2), HADH(1), HADHA(3), HADHB(4), HSD17B4(1), PPT1(2), PPT2(3) 4844496 17 15 16 6 2 5 2 6 2 0 0.609 0.999 1.000 263 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(10), GNA12(1), PRKACB(2), PRKACG(2), PRKAR2B(3) 5689819 18 16 18 6 0 7 0 6 5 0 0.725 0.999 1.000 264 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 CBS(3), CTH(2), DNMT1(2), DNMT3A(9), DNMT3B(2), MARS(6), MAT1A(4), MTAP(2), MTFMT(1), MTR(3), SRM(2), TAT(3) 11786215 39 34 38 8 5 6 0 13 15 0 0.358 0.999 1.000 265 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 CBS(3), CTH(2), DNMT1(2), DNMT3A(9), DNMT3B(2), MARS(6), MAT1A(4), MTR(3) 9864088 31 27 31 6 4 5 0 12 10 0 0.386 0.999 1.000 266 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 TGDS(1), UGDH(2), UGP2(3) 2850554 6 6 6 4 0 2 0 2 2 0 0.959 0.999 1.000 267 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 71 AKT1(2), AKT2(3), AKT3(2), FCER1A(1), FYN(1), GAB2(5), IL4(1), IL5(1), LAT(1), LCP2(5), LYN(1), MAP2K2(2), MAP2K3(2), MAP2K4(4), MAP2K6(2), MAP2K7(2), MAPK1(3), MAPK10(3), MAPK11(1), MAPK12(1), MAPK14(3), MAPK8(1), MAPK9(3), MS4A2(3), NRAS(3), PDK1(1), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIK3R1(4), PIK3R2(4), PIK3R3(2), PIK3R5(1), PLA2G12B(1), PLA2G2D(1), PLA2G2F(5), PLA2G3(7), PLA2G4A(8), PLA2G6(3), PLCG1(7), PLCG2(7), PRKCA(1), RAC3(1), RAF1(2), SOS1(8), SOS2(4), SYK(1), TNF(1), VAV1(3), VAV3(8) 38960851 149 97 144 20 10 30 15 47 46 1 0.00147 1.000 1.000 268 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 45 AKT1(2), AKT2(3), AKT3(2), BCL2(1), BCR(2), BLNK(3), CD19(2), CD22(5), CD81(2), CR2(9), CSK(1), DAG1(1), FLOT1(3), GSK3A(1), GSK3B(3), ITPR1(15), ITPR2(11), ITPR3(11), LYN(1), MAP4K1(1), MAPK1(3), NFATC1(2), NFATC2(7), NR0B2(4), PDK1(1), PIK3CD(5), PIK3R1(4), PLCG2(7), PPP1R13B(4), PPP3CA(3), PPP3CB(3), PTPRC(8), RAF1(2), SHC1(3), SOS1(8), SOS2(4), SYK(1), VAV1(3) 40504673 151 110 150 20 16 37 21 51 25 1 6.03e-05 1.000 1.000 269 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD3G(1), IFNG(3), IL2RA(1), IL4(1), TGFB1(1), TGFB2(4), TGFB3(2), TGFBR1(1), TGFBR2(1), TOB1(4), TOB2(1) 6064526 20 19 20 7 1 5 1 8 5 0 0.821 1.000 1.000 270 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 DHRS1(1), DHRS3(1), DHRS7(1), HSD3B7(1), PON1(1), PON2(1), PON3(3), RDH11(1), RDH13(1), RDH14(1) 5002837 12 11 12 4 2 4 0 5 1 0 0.718 1.000 1.000 271 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 6 IL13RA1(2), IL13RA2(2), IL4R(1), JAK2(4), TYK2(1) 4537383 10 9 10 4 1 1 0 3 5 0 0.903 1.000 1.000 272 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 6 IL13RA1(2), IL13RA2(2), IL4R(1), JAK2(4), TYK2(1) 4537383 10 9 10 4 1 1 0 3 5 0 0.903 1.000 1.000 273 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP3(3), DFFB(1), GZMB(2), HMGB1(2), HMGB2(1), TOP2A(4), TOP2B(6) 5978187 19 18 19 9 1 2 3 7 6 0 0.960 1.000 1.000 274 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 23 AKT1(2), APC(12), CCND1(1), DVL1(3), FZD1(2), GJA1(1), GNAI1(4), GSK3B(3), IRAK1(5), LBP(3), LEF1(2), LY96(1), MYD88(1), NFKB1(3), PDPK1(1), PIK3R1(4), PPP2CA(2), RELA(4), TIRAP(2), TLR4(5), WNT1(2) 14669599 63 50 63 14 1 18 7 16 20 1 0.203 1.000 1.000 275 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ALDH18A1(1), ARG1(1), ARG2(1), ASL(1), CKB(1), CKM(2), CKMT1B(1), CKMT2(2), CPS1(12), GAMT(1), GATM(4), GLUD1(3), NAGS(1), OAT(2), ODC1(3), PYCR1(1), SMS(1) 10612390 38 30 38 9 2 10 8 7 11 0 0.234 1.000 1.000 276 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), MIOX(1), UGDH(2) 4829851 10 8 10 3 0 3 0 5 2 0 0.676 1.000 1.000 277 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 ALOX5(3), CYP2C18(1), CYP2C8(3), CYP2C9(3), CYP2E1(4), CYP3A4(1), CYP3A43(1), CYP3A5(4), HSD3B7(1), PLA2G12B(1), PLA2G2D(1), PLA2G2F(5), PLA2G3(7), PLA2G4A(8), PLA2G6(3), RDH11(1), RDH13(1), RDH14(1) 13738699 49 44 47 10 6 10 3 15 15 0 0.150 1.000 1.000 278 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 10 ATM(9), CDC25B(2), CDC25C(3), CHEK1(5), MYT1(2), WEE1(2) 8496421 23 22 23 5 2 2 2 10 7 0 0.503 1.000 1.000 279 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 20 AKT1(2), EIF4A2(3), EIF4G1(7), EIF4G2(4), EIF4G3(6), GHR(3), IRS1(3), MAPK1(3), MAPK14(3), MKNK1(2), PDK2(1), PDPK1(1), PIK3R1(4), PRKCA(1), RPS6KB1(2) 14325091 45 33 43 9 2 10 10 6 16 1 0.191 1.000 1.000 280 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(9), BIRC2(4), BIRC3(1), CASP10(2), CASP3(3), CASP4(3), CASP6(2), CASP8(1), CASP9(1), DFFB(1), GZMB(2), LMNA(2), LMNB2(2), PRF1(4) 10929741 37 31 37 8 1 12 1 10 13 0 0.509 1.000 1.000 281 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(3), PARK2(1), SNCA(1), SNCAIP(2), UBE2E2(1), UBE2L3(1) 3503895 9 9 9 7 0 2 2 4 1 0 0.964 1.000 1.000 282 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(2), FUCA1(1), FUCA2(1), GLB1(3), HEXA(3), HEXB(1), LCT(6), MAN2B1(2), MAN2B2(3), MAN2C1(5), MANBA(1), NEU1(2), NEU2(4), NEU3(2), NEU4(2) 11833282 38 33 37 9 5 9 6 10 8 0 0.215 1.000 1.000 283 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 7 IFNAR1(2), IFNAR2(1), IFNB1(2), STAT1(5), TYK2(1) 4797141 11 11 11 4 1 4 1 4 1 0 0.675 1.000 1.000 284 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG5(3), B4GALT2(1), B4GALT3(2), B4GALT5(1), DDOST(1), DPM1(1), FUT8(2), MAN1A1(3), MAN1B1(1), MGAT1(3), MGAT2(2), MGAT3(4), MGAT4A(2), MGAT5(4), RPN1(1), RPN2(2), ST6GAL1(1) 11430884 34 28 34 7 3 9 2 12 8 0 0.235 1.000 1.000 285 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(1), MTMR1(2), MTMR2(1), MTMR6(4), PHPT1(1), TPK1(2) 3584135 11 10 11 5 1 1 0 7 2 0 0.944 1.000 1.000 286 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(5), ADRB2(3), CFTR(3), GNAS(10), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), SLC9A3R1(1) 7584063 30 26 27 7 6 9 2 10 3 0 0.379 1.000 1.000 287 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(5), CAPN2(1), CAPNS1(1), EP300(11), HDAC2(3), MEF2D(3), NFATC1(2), NFATC2(7), PPP3CA(3), PPP3CB(3), PRKCA(1), SYT1(2) 13683169 42 35 40 9 4 8 2 19 9 0 0.310 1.000 1.000 288 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(1), CSAD(3), GAD1(5), GAD2(1), GGT1(1) 3303113 11 11 11 5 2 2 0 5 2 0 0.864 1.000 1.000 289 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 CHUK(8), EIF2S2(1), NFKB1(3), NFKBIA(2), RELA(4) 5268940 18 15 18 7 0 5 3 6 4 0 0.856 1.000 1.000 290 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CSF1(2), IL1B(1), MST1R(5), TNF(1) 3615279 9 8 9 6 3 0 1 3 2 0 0.934 1.000 1.000 291 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(1), BIRC3(1), CASP8(1), FADD(1), RIPK1(4), TNF(1), TNFRSF1A(1), TNFRSF1B(1) 4755756 11 11 11 5 0 4 1 3 3 0 0.873 1.000 1.000 292 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH1A(2), ADH1B(3), ADH4(3), ADH6(1), ADH7(1), ADHFE1(2), ALDH1A3(2), ALDH3B1(1), ALDH3B2(1), AOC2(2), AOC3(1), AOX1(11), DCT(3), DDC(2), GSTZ1(2), HGD(4), HPD(2), MAOA(1), MAOB(8), TAT(3), TH(1), TPO(13), TYR(5) 17964727 74 61 74 14 4 18 8 25 19 0 0.0641 1.000 1.000 293 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(2), ADH1B(3), ADH4(3), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1) 7522765 21 20 21 6 0 3 2 8 8 0 0.679 1.000 1.000 294 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(1), ACTR2(1), ARPC1A(1), ARPC1B(2), ARPC2(3), ARPC3(1), NCK1(1), NCKAP1(3), NTRK1(5), PSMA7(3), WASF1(1), WASF2(2), WASF3(2), WASL(2) 8667168 28 26 27 7 3 13 5 4 3 0 0.203 1.000 1.000 295 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 12 IL10RA(3), IL22(1), IL22RA1(1), JAK2(4), JAK3(7), SOCS3(1), STAT1(5), STAT3(4), STAT5A(2), STAT5B(1), TYK2(1) 9416156 30 27 29 7 4 6 3 13 4 0 0.394 1.000 1.000 296 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 19 ACO1(6), ACO2(3), CS(4), DLD(4), DLST(1), FH(3), IDH2(4), IDH3G(2), MDH1(1), PC(3), PCK1(6), SDHA(2), SDHB(1), SUCLA2(2), SUCLG1(1), SUCLG2(1) 11162775 44 39 43 11 3 8 8 9 15 1 0.387 1.000 1.000 297 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP2A13(2), CYP2A6(3), CYP2A7(4), XDH(8) 4490080 17 16 17 5 0 7 0 8 2 0 0.803 1.000 1.000 298 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 21 EPHB2(4), F2(2), F2RL3(1), JUN(2), MAP2K5(1), MAPK1(3), MAPK7(3), MAPK8(1), MYEF2(3), PLD1(4), PLD2(3), PLD3(4), PTK2(9), RAF1(2), RASAL1(4), SRC(3), VAV1(3) 14845854 52 39 52 8 2 15 7 23 5 0 0.0335 1.000 1.000 299 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(1), ENO1(2), GPI(1), HK1(3), PFKL(1), PKLR(3), TPI1(1) 5148143 12 12 12 5 1 2 1 5 3 0 0.711 1.000 1.000 300 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(3), CS(4), MDH1(1), ME1(1), PC(3), PDHA1(1), SLC25A1(3) 5180489 16 14 16 8 2 4 2 4 4 0 0.916 1.000 1.000 301 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 29 A1BG(3), AKT1(2), AKT2(3), AKT3(2), DAPP1(1), GSK3A(1), GSK3B(3), IARS(5), PDK1(1), PPP1R13B(4), RPS6KA1(1), RPS6KA2(5), RPS6KB1(2), SHC1(3), SOS1(8), SOS2(4), YWHAE(1), YWHAZ(1) 17446072 50 39 49 9 7 13 8 11 10 1 0.0786 1.000 1.000 302 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 14 AKT1(2), CREB1(1), MAP2K2(2), MAP2K3(2), MAP2K6(2), MAP3K1(3), MAPK1(3), MAPK14(3), NFKB1(3), PIK3R1(4), RELA(4), SP1(2) 8867060 31 23 31 7 1 6 5 8 11 0 0.416 1.000 1.000 303 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(1), IL4(1), IL5(1), JUNB(1), MAP2K3(2), MAPK14(3), NFATC1(2), NFATC2(7), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3) 6995965 26 24 26 8 2 5 2 11 6 0 0.744 1.000 1.000 304 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 GALNS(1), GLB1(3), GUSB(8), HEXA(3), HEXB(1), IDS(1), IDUA(1), LCT(6), NAGLU(3) 8475616 27 25 25 8 2 4 5 7 9 0 0.385 1.000 1.000 305 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(2), FOS(1), JAK2(4), PTPN6(2), RAF1(2), SHC1(3), SOS1(8), STAT5A(2), STAT5B(1) 10112812 25 24 25 5 3 3 4 10 4 1 0.320 1.000 1.000 306 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(3), CKM(2), GPT(1), LDHA(1), LDHB(1), LDHC(1), MAPK14(3), NCL(6) 5102549 18 14 17 7 2 3 1 8 4 0 0.851 1.000 1.000 307 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(3), ABCC2(4), ABCG2(2), BCHE(2), CES1(3), CES2(2), CYP3A4(1), CYP3A5(4), UGT1A1(3), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A9(1) 12817743 32 28 32 7 0 11 3 9 9 0 0.274 1.000 1.000 308 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(2), CARS2(1), CTH(2), LDHA(1), LDHAL6A(2), LDHAL6B(2), LDHB(1), LDHC(1), MPST(1), SDS(2), SULT1C2(1), SULT1C4(1), SULT4A1(1) 7113624 18 17 18 7 0 6 2 5 5 0 0.838 1.000 1.000 309 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(2), BCAT2(1), DPYD(6), DPYS(1), ENPP1(1), ENPP3(4), PANK1(1), PANK2(2), PANK4(4), PPCS(1), UPB1(1), VNN1(1) 9912491 25 20 25 5 2 8 4 9 2 0 0.200 1.000 1.000 310 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 ALOX5(3), CYP4F2(1), CYP4F3(2), EPX(3), GGT1(1), LPO(4), MPO(5), PLA2G3(7), PLA2G4A(8), PLA2G6(3), PRDX1(1), PRDX2(2), PRDX6(1), PTGES2(1), PTGIS(2), PTGS1(2), PTGS2(3), TPO(13) 16097893 62 51 60 13 10 8 8 19 17 0 0.0953 1.000 1.000 311 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 22 AKT1(2), APC(12), ASAH1(2), CAMP(1), DAG1(1), EPHB2(4), GNAI1(4), GNAQ(1), ITPR1(15), ITPR2(11), ITPR3(11), KCNJ3(3), MAPK1(3), PITX2(1), PTX3(1), RHO(3), RYR1(31) 25508956 106 80 104 18 14 23 5 40 23 1 0.0238 1.000 1.000 312 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(2), CTH(2), LDHA(1), LDHB(1), LDHC(1), MPST(1) 3802812 8 8 8 4 0 5 0 2 1 0 0.858 1.000 1.000 313 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 21 ADCY1(5), AKT1(2), ASAH1(2), GNAI1(4), GNB1(2), ITGAV(3), ITGB3(5), MAPK1(3), PDGFA(2), PDGFRA(5), PIK3R1(4), PLCB1(8), PRKCA(1), PTK2(9), SMPD1(4), SMPD2(4), SPHK1(7), SRC(3) 14153266 73 56 71 17 2 22 5 23 21 0 0.329 1.000 1.000 314 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 36 FCER1A(1), FOS(1), JUN(2), LYN(1), MAP2K4(4), MAP2K7(2), MAP3K1(3), MAPK1(3), MAPK8(1), NFATC1(2), NFATC2(7), NFATC3(4), NFATC4(5), PAK2(3), PIK3R1(4), PLA2G4A(8), PLCG1(7), PPP3CA(3), PPP3CB(3), RAF1(2), SHC1(3), SOS1(8), SYK(1), SYT1(2), VAV1(3) 22924318 83 64 81 15 8 14 10 26 24 1 0.0502 1.000 1.000 315 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(4), ICAM1(1), ITGAL(5), ITGAM(6), ITGB2(8), SELE(1) 6042336 25 23 24 9 2 9 1 8 5 0 0.855 1.000 1.000 316 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA2(1), ADH1A(2), ADH1B(3), ADH4(3), ADH6(1), ADH7(1), ADHFE1(2), AKR1C4(1), AKR1D1(3), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH9A1(1), BAAT(1), CEL(3), CYP27A1(4), CYP7A1(1), HADHB(4), SOAT2(1), SRD5A1(1) 13154919 40 35 40 9 3 10 4 17 6 0 0.201 1.000 1.000 317 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(1), B3GNT2(1), B3GNT7(1), B4GALT2(1), B4GALT3(2), CHST2(3), CHST6(2), FUT8(2), ST3GAL1(1), ST3GAL2(1) 6818649 15 15 15 5 3 2 1 5 4 0 0.685 1.000 1.000 318 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(2), CAMP(1), CREB1(1), CREB5(2), MAPK1(3), RAF1(2), SNX13(2), SRC(3), TERF2IP(1) 6611335 17 17 17 5 2 2 2 7 4 0 0.681 1.000 1.000 319 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 HK1(3), HK2(3), HK3(5), IMPA1(2), IMPA2(2), ISYNA1(1), PGM1(1), PGM3(2), TGDS(1) 6733517 20 20 20 9 0 3 3 10 4 0 0.800 1.000 1.000 320 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 ANPEP(3), G6PD(1), GCLC(1), GCLM(1), GGT1(1), GPX7(1), GSR(3), GSS(1), GSTA2(1), GSTA4(1), GSTA5(1), GSTK1(1), GSTM3(1), GSTM5(1), GSTP1(2), GSTZ1(2), IDH2(4), MGST2(1), OPLAH(5) 12870047 32 28 32 7 4 6 3 12 7 0 0.221 1.000 1.000 321 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 HK1(3), HK2(3), HK3(5), IMPA1(2), PGM1(1), PGM3(2), TGDS(1) 5895828 17 17 17 9 0 3 3 8 3 0 0.852 1.000 1.000 322 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 61 APAF1(9), ATM(9), ATR(15), BAI1(5), BAX(3), CASP3(3), CASP8(1), CASP9(1), CCNB1(2), CCNB2(1), CCNB3(4), CCND1(1), CCND2(3), CCNE1(1), CCNE2(2), CCNG1(1), CD82(3), CDK6(1), CHEK1(5), CHEK2(5), DDB2(3), EI24(2), FAS(3), GADD45G(1), GTSE1(3), IGFBP3(2), MDM2(1), MDM4(1), PPM1D(2), RCHY1(1), RFWD2(4), RPRM(1), SERPINE1(1), SESN1(1), SESN2(3), SESN3(2), SIAH1(4), STEAP3(2), THBS1(6), TNFRSF10B(2), TP73(2), TSC2(12), ZMAT3(1) 36092414 135 95 132 22 11 29 11 47 36 1 0.00753 1.000 1.000 323 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(4), ACE2(1), AGT(1), AGTR1(2), ANPEP(3), CPA3(3), CTSA(1), CTSG(1), ENPEP(2), LNPEP(6), MME(6), THOP1(3) 11883066 33 26 32 9 0 8 2 9 14 0 0.563 1.000 1.000 324 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 21 ABL1(2), ATM(9), ATR(15), CCNA1(3), CCND1(1), CCNE1(1), CDK6(1), CDKN1B(5), CDKN2B(1), E2F1(3), GSK3B(3), SKP2(1), TFDP1(2), TGFB1(1), TGFB2(4), TGFB3(2) 15080031 54 45 53 10 2 9 2 28 12 1 0.253 1.000 1.000 325 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 25 CHUK(8), CRADD(1), IKBKB(4), JUN(2), MAP2K3(2), MAP2K4(4), MAP2K6(2), MAP3K1(3), MAP4K2(4), MAPK14(3), MAPK8(1), NFKB1(3), NFKBIA(2), RELA(4), RIPK1(4), TNF(1), TNFRSF1A(1) 14227411 49 38 49 10 3 11 6 14 15 0 0.342 1.000 1.000 326 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(2), ACP2(1), ACP5(1), ACPP(6), ACPT(1), ENPP1(1), ENPP3(4), FLAD1(2), RFK(1), TYR(5) 5519999 24 20 24 8 0 6 5 9 4 0 0.674 1.000 1.000 327 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(1), DHRS3(1), DHRS7(1), ESCO1(2), ESCO2(3), NAT6(1), PNPLA3(1), SH3GLB1(2) 9099240 12 11 12 3 1 3 1 6 1 0 0.415 1.000 1.000 328 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), B4GALT7(1), HS3ST1(3), HS3ST2(1), HS3ST3A1(1), XYLT1(3), XYLT2(1) 3940176 11 11 11 9 0 3 2 5 1 0 0.994 1.000 1.000 329 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), B4GALT7(1), HS3ST1(3), HS3ST2(1), HS3ST3A1(1), XYLT1(3), XYLT2(1) 3940176 11 11 11 9 0 3 2 5 1 0 0.994 1.000 1.000 330 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(1), B4GALNT1(1), GLB1(3), HEXA(3), HEXB(1), LCT(6), SLC33A1(2), ST3GAL1(1), ST3GAL2(1), ST6GALNAC3(2), ST6GALNAC5(3), ST8SIA5(2) 9218875 26 24 25 8 1 5 8 5 7 0 0.421 1.000 1.000 331 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(9), BAX(3), BCL2(1), BIRC2(4), BIRC3(1), CASP3(3), CASP6(2), CASP8(1), CASP9(1), FADD(1), FAS(3), GZMB(2), JUN(2), MAP2K4(4), MAP3K1(3), MAPK10(3), MCL1(2), MDM2(1), MYC(2), NFKB1(3), NFKBIA(2), PARP1(5), PRF1(4), RELA(4), RIPK1(4), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TNFSF10(1), TRAF1(1) 20993648 75 58 72 16 5 22 8 21 19 0 0.222 1.000 1.000 332 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CAMK1(1), CAMK1G(2), CAMK2A(6), CAMK2B(2), CAMK2G(3), ESRRA(2), HDAC5(4), MEF2A(6), MEF2C(1), MEF2D(3), PPARA(3), PPP3CA(3), PPP3CB(3), SLC2A4(2), SYT1(2) 12013009 43 36 42 10 4 9 2 21 7 0 0.325 1.000 1.000 333 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(2), CYSLTR2(3), GPR161(4), GPR34(1), GPR45(1), GPR65(2), GPR68(3) 5502944 16 16 16 6 3 3 1 8 1 0 0.768 1.000 1.000 334 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(10), ATP6AP1(2), ATP6V0A1(6), ATP6V0A4(3), ATP6V0C(2), ATP6V0D1(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1D(4), ATP6V1E1(1), ATP6V1F(2), ATP6V1H(1), ATP7A(6), ATP7B(3), COX10(1), COX5A(2), COX5B(2), COX6B1(2), NDUFA10(1), NDUFA5(2), NDUFA8(1), NDUFB5(1), NDUFB6(1), NDUFB7(2), NDUFS1(2), NDUFS2(2), NDUFV2(2), SDHA(2), SDHB(1), SHMT1(2), UQCRB(1) 21624045 74 61 73 14 2 25 6 27 14 0 0.0693 1.000 1.000 335 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX15B(4), ALOX5(3), GGT1(1), PLA2G6(3), PTGIS(2), PTGS1(2), PTGS2(3) 8902094 18 17 18 7 8 0 0 5 5 0 0.744 1.000 1.000 336 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(1), CAPN1(2), CAPN2(1), CAPNS1(1), CXCR3(3), EGF(6), EGFR(6), ITGA1(5), MAPK1(3), MYLK(3), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), PTK2(9), PXN(2), TLN1(10) 18934784 60 49 59 11 3 21 5 17 14 0 0.122 1.000 1.000 337 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(3), ACADM(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), AOC2(2), AOC3(1), DPYD(6), DPYS(1), ECHS1(2), EHHADH(10), GAD1(5), GAD2(1), HADHA(3), HIBCH(6), SMS(1), SRM(2), UPB1(1) 15182787 52 37 50 12 3 12 6 22 9 0 0.156 1.000 1.000 338 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 33 ADCY1(5), CREB1(1), FOS(1), GNAI1(4), GNAQ(1), GNAS(10), GNB1(2), JUN(2), NFATC1(2), NFATC2(7), NFATC3(4), NFATC4(5), PLCG1(7), PPP3CA(3), PPP3CB(3), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), PRKCA(1), RAF1(2), SYT1(2) 19043749 70 54 65 15 11 17 5 24 13 0 0.207 1.000 1.000 339 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 29 ADCY3(2), ADRBK2(2), ARRB2(1), CALML6(2), CAMK2A(6), CAMK2B(2), CAMK2G(3), CLCA1(8), CLCA2(10), CLCA4(2), CNGA4(3), CNGB1(4), GNAL(2), GUCA1A(1), PDE1C(9), PRKACA(2), PRKACB(2), PRKACG(2), PRKG1(6), PRKG2(4), PRKX(3) 16758464 76 51 75 17 6 22 7 20 19 2 0.134 1.000 1.000 340 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD86(2), HLA-DRA(1), HLA-DRB1(1), IFNG(3), IFNGR1(3), IFNGR2(1), IL12A(6), IL12B(2), IL12RB1(3), IL12RB2(5), IL18(2), IL18R1(2), IL2RA(1), IL4(1), IL4R(1) 7085266 34 28 34 10 0 8 4 15 7 0 0.541 1.000 1.000 341 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 ASNS(3), ASRGL1(1), CA1(1), CA14(1), CA4(2), CA5A(1), CA5B(1), CA6(1), CA8(1), CA9(7), CPS1(12), CTH(2), GLS(4), GLS2(1), GLUD1(3), GLUD2(5), GLUL(1) 11875556 47 41 47 12 3 12 12 12 8 0 0.226 1.000 1.000 342 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 10 ARNT(2), EPOR(1), GRIN1(5), HIF1A(3), JAK2(4), NFKB1(3), NFKBIA(2), RELA(4) 7231261 24 22 23 9 0 4 2 12 6 0 0.952 1.000 1.000 343 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(1), AKR1D1(3), ARSD(3), ARSE(2), CYP11B1(4), CYP11B2(5), CYP19A1(1), HEMK1(3), HSD11B1(2), HSD17B3(2), HSD17B7(1), HSD17B8(1), HSD3B1(2), LCMT2(3), METTL2B(5), METTL6(3), PRMT2(1), PRMT3(1), PRMT5(2), PRMT6(3), PRMT7(1), PRMT8(3), SRD5A1(1), STS(4), SULT1E1(1), UGT1A1(3), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A9(1), UGT2A1(2), UGT2B11(1), UGT2B15(1), UGT2B17(1), UGT2B28(1), UGT2B4(5), UGT2B7(5), WBSCR22(2) 27278284 87 72 86 16 8 23 9 24 22 1 0.0910 1.000 1.000 344 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(2), AASDH(4), AASS(5), ACAT1(2), ACAT2(5), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH9A1(1), ATP6V0C(2), BBOX1(3), DLST(1), DOT1L(7), ECHS1(2), EHHADH(10), EHMT1(4), EHMT2(5), GCDH(1), HADHA(3), PLOD1(1), PLOD2(6), PLOD3(1), SDS(2), SHMT1(2), SHMT2(4) 20854876 80 56 80 17 3 20 10 26 21 0 0.144 1.000 1.000 345 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSR(3), GSS(1), NFKB1(3), NOX1(3), RELA(4), TNF(1), XDH(8) 5698410 23 20 23 8 0 7 3 9 4 0 0.775 1.000 1.000 346 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(12), ASAH1(2), CAMP(1), CASP3(3), CREB1(1), CREB5(2), DAG1(1), EPHB2(4), FOS(1), GNAQ(1), ITPKA(1), ITPKB(4), JUN(2), MAP2K4(4), MAP2K7(2), MAPK1(3), MAPK10(3), MAPK8(1), MAPK8IP1(1), MAPK8IP3(2), MAPK9(3) 16333098 54 48 54 12 3 8 6 18 18 1 0.405 1.000 1.000 347 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3B1(1), ALDH3B2(1), ALDH9A1(1), AOC2(2), AOC3(1), DDC(2), HARS(1), HDC(4), MAOA(1), MAOB(8), PRPS1(1) 13790583 30 24 30 6 2 6 2 12 8 0 0.243 1.000 1.000 348 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(8), APOA1(2), APOA4(2), APOE(1), CETP(2), CYP7A1(1), DGAT1(4), HMGCR(6), LCAT(3), LDLR(2), LIPC(2), LPL(1), LRP1(19) 15296221 53 45 53 12 5 12 9 19 6 2 0.226 1.000 1.000 349 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(3), CD79B(1), FOS(1), JUN(2), LYN(1), MAP3K1(3), MAPK14(3), MAPK8(1), NFATC1(2), NFATC2(7), NFATC3(4), NFATC4(5), PLCG1(7), PPP3CA(3), PPP3CB(3), PRKCA(1), RAF1(2), SHC1(3), SOS1(8), SYK(1), SYT1(2), VAV1(3) 21438349 66 53 64 13 8 14 10 22 11 1 0.0834 1.000 1.000 350 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 38 AKT1(2), AKT2(3), AKT3(2), BCR(2), BLNK(3), CD19(2), CSK(1), DAG1(1), EPHB2(4), ITPKA(1), ITPKB(4), LYN(1), MAP2K2(2), MAPK1(3), NFAT5(6), NFKB1(3), NFKB2(2), NFKBIA(2), NFKBIL1(1), PIK3CD(5), PIK3R1(4), PLCG2(7), PPP1R13B(4), RAF1(2), SERPINA4(2), SHC1(3), SOS1(8), SOS2(4), SYK(1), VAV1(3) 28956559 88 67 88 15 7 27 12 25 16 1 0.0283 1.000 1.000 351 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 29 AKT1(2), CABIN1(5), CAMK1(1), CAMK1G(2), HDAC5(4), IGF1R(11), INS(1), INSR(4), MAP2K6(2), MAPK14(3), MAPK7(3), MEF2A(6), MEF2C(1), MEF2D(3), MYOD1(1), NFATC1(2), NFATC2(7), PIK3R1(4), PPP3CA(3), PPP3CB(3), SYT1(2) 18711182 70 50 70 15 8 12 9 26 15 0 0.143 1.000 1.000 352 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CREB1(1), CREBBP(6), EP300(11), NCOA3(10), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), RARA(1), RXRA(2) 11648855 39 32 37 10 0 12 2 14 11 0 0.623 1.000 1.000 353 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 33 AKT1(2), APC(12), AR(14), ASAH1(2), CAMP(1), CCL13(1), CCL15(1), CCL16(1), DAG1(1), EGFR(6), GNA15(1), GNAI1(4), GNAQ(1), ITPKA(1), ITPKB(4), ITPR1(15), ITPR2(11), ITPR3(11), KCNJ3(3), MAPK1(3), MAPK10(3), MAPK14(3), PHKA2(3), PIK3CD(5), PIK3R1(4), PITX2(1), PTX3(1), RAF1(2), SRC(3) 29455028 120 85 112 22 10 28 11 46 24 1 0.0399 1.000 1.000 354 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 45 AKT1(2), AKT2(3), AKT3(2), BRD4(6), CBL(4), CDC42(3), FLOT1(3), GSK3A(1), GSK3B(3), INPPL1(1), IRS1(3), IRS2(2), IRS4(7), LNPEP(6), MAPK1(3), PARD3(3), PDK1(1), PIK3CD(5), PIK3R1(4), RAF1(2), RPS6KA1(1), RPS6KA2(5), RPS6KB1(2), SERPINB6(2), SHC1(3), SLC2A4(2), SORBS1(1), SOS1(8), SOS2(4), YWHAE(1), YWHAZ(1) 30595599 94 78 93 17 10 20 17 25 21 1 0.0129 1.000 1.000 355 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(1), CHUK(8), IFNG(3), IKBKB(4), IL4(1), JUN(2), MAP3K1(3), MAP3K5(1), MAP4K5(7), MAPK14(3), MAPK8(1), NFKB1(3), NFKBIA(2), RELA(4) 11230841 43 33 42 11 1 13 5 14 10 0 0.480 1.000 1.000 356 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 28 CREB1(1), CREB5(2), DUSP4(1), DUSP6(2), DUSP9(1), EEF2K(1), MAP2K2(2), MAP3K8(1), MAPK1(3), MKNK1(2), MKNK2(3), MOS(2), NFKB1(3), RAP1A(2), RPS6KA1(1), RPS6KA2(5), SHC1(3), SOS1(8), SOS2(4), TRAF3(1) 16146890 48 40 48 10 10 11 8 12 6 1 0.112 1.000 1.000 357 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 GABRA1(5), GABRA2(7), GABRA3(1), GABRA4(6), GABRA5(4), GABRA6(7), GPHN(6), SRC(3), UBQLN1(3) 7219873 42 36 39 13 1 8 1 21 11 0 0.808 1.000 1.000 358 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 71 B2M(1), CANX(1), CD4(1), CD74(1), CD8A(1), CD8B(1), CIITA(6), CREB1(1), CTSB(2), CTSS(1), HLA-A(3), HLA-B(3), HLA-C(2), HLA-DMA(2), HLA-DMB(1), HLA-DOB(1), HLA-DQA1(1), HLA-DQA2(1), HLA-DQB1(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(1), HLA-E(3), HLA-G(3), HSP90AA1(5), HSP90AB1(4), HSPA5(1), IFI30(2), IFNA13(1), IFNA14(3), IFNA16(1), IFNA17(1), IFNA2(2), IFNA4(1), IFNA5(2), IFNA6(2), IFNA7(1), IFNA8(4), KIR2DL3(3), KLRC1(1), KLRC3(2), KLRC4(1), NFYA(2), NFYB(1), NFYC(2), PDIA3(1), PSME1(1), RFX5(3), RFXAP(1), TAP1(2) 25906683 90 71 89 19 4 13 9 36 28 0 0.321 1.000 1.000 359 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CAMK1(1), CAMK1G(2), FPR1(1), GNA15(1), GNB1(2), MAP2K2(2), MAP2K3(2), MAP2K6(2), MAP3K1(3), MAPK1(3), MAPK14(3), NCF1(1), NCF2(1), NFATC1(2), NFATC2(7), NFATC3(4), NFATC4(5), NFKB1(3), NFKBIA(2), PAK1(3), PIK3C2G(7), PLCB1(8), PPP3CA(3), PPP3CB(3), RAF1(2), RELA(4), SYT1(2) 22214157 79 58 78 17 6 17 10 32 14 0 0.201 1.000 1.000 360 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(6), EP300(11), ESR1(6), MAPK1(3), PELP1(5), SRC(3) 8573034 34 29 33 10 1 12 3 12 6 0 0.469 1.000 1.000 361 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 13 AKT1(2), BCL2(1), EGFR(6), IGF1R(11), MYC(2), POLR2A(7), PPP2CA(2), PRKCA(1), TEP1(13), TERF1(5), TERT(2), TNKS(3), XRCC5(4) 14249630 59 49 58 14 2 16 3 21 17 0 0.505 1.000 1.000 362 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(3), AR(14), ESR1(6), ESR2(1), ESRRA(2), HNF4A(3), NPM1(1), NR0B1(3), NR1D1(1), NR1D2(1), NR1H2(2), NR1H3(4), NR1I2(3), NR1I3(2), NR2C2(2), NR2E1(1), NR2F1(2), NR2F2(4), NR2F6(1), NR3C1(3), NR4A1(3), NR4A2(6), NR5A1(2), NR5A2(3), PGR(5), PPARA(3), PPARG(1), RARA(1), RARB(1), RARG(4), ROR1(3), RORA(4), RORC(1), RXRA(2), RXRB(8), RXRG(2) 24247961 108 77 98 23 10 22 12 41 23 0 0.104 1.000 1.000 363 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(1), AGT(1), AGTR1(2), COL4A1(8), COL4A2(6), COL4A3(3), COL4A4(9), COL4A5(9), COL4A6(6) 14520565 45 37 44 13 1 8 7 16 13 0 0.307 1.000 1.000 364 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 18 CHUK(8), DUSP1(1), IKBKAP(5), IKBKB(4), MAP3K1(3), NFKB1(3), NFKBIA(2), RELA(4), RIPK1(4), TNFAIP3(1), TNFRSF1B(1), TRAF1(1), TRAF3(1) 13148977 38 30 38 9 0 12 7 11 8 0 0.419 1.000 1.000 365 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(1), ATG5(5), ATG7(2), BECN1(2), IFNA13(1), IFNA14(3), IFNA16(1), IFNA17(1), IFNA2(2), IFNA4(1), IFNA5(2), IFNA6(2), IFNA7(1), IFNA8(4), IFNG(3), INS(1), PIK3C3(2), PIK3R4(4), PRKAA1(4), ULK1(3), ULK2(5), ULK3(1) 12117981 51 40 50 12 1 13 4 23 10 0 0.401 1.000 1.000 366 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(3), GTF2A1(2), GTF2B(3), GTF2E1(3), GTF2F1(1), NCOA1(5), NCOA2(5), NCOA3(10), NCOR2(14), POLR2A(7), RARA(1), RXRA(2), TBP(1) 14264377 57 46 54 15 6 12 8 13 18 0 0.308 1.000 1.000 367 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(12), CDH1(7), CREBBP(6), EP300(11), MAP3K7(3), SKIL(1), TGFB1(1), TGFB2(4), TGFB3(2), TGFBR1(1), TGFBR2(1) 14442911 49 43 47 12 1 13 3 19 12 1 0.360 1.000 1.000 368 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 29 AKT1(2), AKT2(3), AKT3(2), ANKRD6(3), APC(12), AXIN2(6), CER1(1), CSNK1A1(2), DACT1(3), DKK1(1), DKK2(4), DKK3(4), DVL1(3), GSK3A(1), GSK3B(3), LRP1(19), MVP(2), NKD1(2), NKD2(3), PIN1(2), PSEN1(2), PTPRA(4), SENP2(3), WIF1(6) 21291783 93 69 90 20 2 21 11 33 24 2 0.216 1.000 1.000 369 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 22 CHUK(8), FADD(1), IKBKB(4), IL1R1(4), IRAK1(5), MAP3K1(3), MAP3K7(3), MYD88(1), NFKB1(3), NFKBIA(2), RELA(4), RIPK1(4), TLR4(5), TNF(1), TNFAIP3(1), TNFRSF1A(1), TNFRSF1B(1), TRAF6(2) 14286427 53 41 53 12 0 18 7 19 9 0 0.259 1.000 1.000 370 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(11), BST1(1), CD38(3), ENPP1(1), ENPP3(4), NADK(3), NMNAT1(2), NMNAT3(1), NNT(4), NT5C1B(3), NT5C2(1), NT5E(1), NT5M(2), NUDT12(3) 12171927 40 33 39 10 0 16 6 10 7 1 0.298 1.000 1.000 371 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 7 IFNAR1(2), IFNB1(2), PTPRU(2), REG1A(1), STAT1(5), TYK2(1) 5729432 13 12 13 5 1 5 1 5 1 0 0.767 1.000 1.000 372 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 37 AKT1(2), ATF2(1), CDC42(3), DLD(4), DUSP4(1), DUSP8(2), GAB1(3), IL1R1(4), JUN(2), MAP2K4(4), MAP2K5(1), MAP2K7(2), MAP3K1(3), MAP3K10(1), MAP3K11(1), MAP3K12(2), MAP3K13(4), MAP3K2(5), MAP3K3(1), MAP3K4(9), MAP3K5(1), MAP3K7(3), MAP3K9(3), MAPK10(3), MAPK7(3), MAPK8(1), MAPK9(3), MYEF2(3), NFATC3(4), NR2C2(2), PAPPA(5), SHC1(3), TRAF6(2), ZAK(3) 27986749 94 69 94 18 9 20 11 29 24 1 0.0433 1.000 1.000 373 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 17 ABL1(2), ATM(9), BRCA1(9), CHEK1(5), CHEK2(5), JUN(2), MAPK8(1), MDM2(1), NFKB1(3), NFKBIA(2), RAD50(6), RAD51(2), RBBP8(3), RELA(4), TP73(2) 15983760 56 44 56 12 4 10 6 20 15 1 0.332 1.000 1.000 374 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(2), ACP2(1), ACP5(1), ACPP(6), ACPT(1), ALPI(1), ALPL(1), ALPP(4), ALPPL2(2), CMBL(2), CYP3A4(1), CYP3A43(1), CYP3A5(4), DHRS1(1), DHRS3(1), DHRS7(1), PON1(1), PON2(1), PON3(3) 10405360 35 32 35 10 1 6 4 16 8 0 0.660 1.000 1.000 375 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 31 ACTR2(1), AKT1(2), ANGPTL2(1), DAG1(1), DGKA(4), GCA(1), ITGA9(5), ITPKA(1), ITPKB(4), ITPR1(15), ITPR2(11), ITPR3(11), MAPK1(3), NR1I3(2), PAK1(3), PDE3A(8), PDE3B(2), PIK3C2G(7), PIK3CD(5), PIK3R1(4), PSME1(1), RIPK3(6), SGCB(1), VASP(2) 26916321 101 73 100 19 11 27 9 37 17 0 0.0439 1.000 1.000 376 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 FYN(1), LRP8(3), RELN(12), VLDLR(2) 7810921 18 18 18 9 1 5 4 6 2 0 0.898 1.000 1.000 377 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(8), COL4A2(6), COL4A3(3), COL4A4(9), COL4A5(9), COL4A6(6), F10(3), F11(1), F12(1), F2(2), F2R(1), F5(7), F8(5), FGA(12), FGB(3), KLKB1(3), PROC(2), SERPINC1(2), SERPING1(3) 25380265 86 70 84 20 2 21 15 28 20 0 0.0697 1.000 1.000 378 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 ANPEP(3), G6PD(1), GCLC(1), GCLM(1), GGT1(1), GSS(1), GSTA2(1), GSTA4(1), GSTM3(1), GSTM5(1), GSTP1(2), GSTZ1(2), IDH2(4), MGST2(1) 10388436 21 19 21 6 2 5 1 8 5 0 0.577 1.000 1.000 379 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 20 ATM(9), ATR(15), BRCA1(9), CCNB1(2), CDC25B(2), CDC25C(3), CDC34(1), CHEK1(5), CHEK2(5), EP300(11), MDM2(1), MYT1(2), PRKDC(6), RPS6KA1(1), WEE1(2) 23640298 74 62 73 14 4 10 8 31 19 2 0.132 1.000 1.000 380 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 DUSP1(1), MAP2K4(4), MAP2K7(2), MAPK1(3), MAPK10(3), MAPK11(1), MAPK12(1), MAPK14(3), MAPK8(1), MAPK8IP1(1), MAPK8IP3(2), MAPK9(3), MAPKAPK5(3), NFKB1(3), NFKB2(2), NFKBIA(2), NFKBIL1(1), PIK3CD(5), PIK3R1(4), SYT1(2), TRAF3(1), TRAF5(2), TRAF6(2) 19406303 52 42 52 11 3 11 4 15 19 0 0.323 1.000 1.000 381 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 14 BCL2(1), CREBBP(6), EP300(11), FYN(1), IL2RG(1), IL7(1), IL7R(1), JAK3(7), LCK(4), NMI(2), PIK3R1(4), PTK2B(5), STAT5A(2), STAT5B(1) 13327373 47 40 46 12 3 14 2 16 12 0 0.396 1.000 1.000 382 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 61 AKT1(2), AKT2(3), AKT3(2), BCL10(1), BLNK(3), CARD11(11), CD19(2), CD22(5), CD79B(1), CD81(2), CHUK(8), CR2(9), FOS(1), GSK3B(3), IKBKB(4), JUN(2), LILRB3(3), LYN(1), MALT1(3), NFAT5(6), NFATC1(2), NFATC2(7), NFATC3(4), NFATC4(5), NFKB1(3), NFKB2(2), NFKBIA(2), NRAS(3), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIK3R1(4), PIK3R2(4), PIK3R3(2), PIK3R5(1), PLCG2(7), PPP3CA(3), PPP3CB(3), PTPN6(2), RAC3(1), RASGRP3(1), SYK(1), VAV1(3), VAV3(8) 41316928 153 102 151 26 11 44 19 46 33 0 0.00302 1.000 1.000 383 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 12 APC(12), CREBBP(6), DVL1(3), EP300(11), FZD1(2), GSK3B(3), LDB1(3), LEF1(2), PITX2(1), TRRAP(9), WNT1(2) 16858006 54 47 53 14 3 18 4 17 11 1 0.338 1.000 1.000 384 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ADH1A(2), ADH1B(3), ADH4(3), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), ALDH1A3(2), ALDH3B1(1), ALDH3B2(1), AOC2(2), AOC3(1), AOX1(11), DCT(3), DDC(2), ECH1(1), ESCO1(2), ESCO2(3), GSTZ1(2), HEMK1(3), HGD(4), HPD(2), LCMT2(3), MAOA(1), MAOB(8), METTL2B(5), METTL6(3), NAT6(1), PNPLA3(1), PRMT2(1), PRMT3(1), PRMT5(2), PRMT6(3), PRMT7(1), PRMT8(3), SH3GLB1(2), TAT(3), TH(1), TPO(13), TYR(5), WBSCR22(2) 33422580 113 87 113 22 8 28 14 37 25 1 0.0245 1.000 1.000 385 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(3), ACADL(2), ACADM(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH9A1(1), AOC2(2), AOC3(1), DPYD(6), DPYS(1), ECHS1(2), EHHADH(10), GAD1(5), GAD2(1), HADHA(3), SDS(2), SMS(1), UPB1(1) 16317750 49 35 49 12 3 10 6 20 10 0 0.303 1.000 1.000 386 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 31 ADRA1B(1), ADRA1D(4), ADRA2C(1), ADRB2(3), ADRB3(1), CHRM1(3), CHRM2(5), CHRM3(7), CHRM4(2), CHRM5(2), DRD1(1), DRD2(4), DRD3(2), DRD5(1), HRH1(2), HTR1A(2), HTR1B(1), HTR1D(1), HTR1E(3), HTR1F(1), HTR2C(3), HTR5A(2), HTR6(1), HTR7(5) 14507373 58 49 56 16 8 8 4 29 9 0 0.313 1.000 1.000 387 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 24 ARNT(2), EIF2B2(2), EIF2B3(2), EIF2B4(1), EIF2B5(1), EIF2S2(1), EIF2S3(1), ELAVL1(4), FLT1(4), FLT4(6), HIF1A(3), KDR(7), NOS3(9), PIK3R1(4), PLCG1(7), PRKCA(1), PTK2(9), PXN(2), SHC1(3) 18408399 69 59 66 17 6 13 1 24 25 0 0.396 1.000 1.000 388 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(10), ACAT1(2), ACAT2(5), ACYP1(1), ADH5(2), AKR1B1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH9A1(1), DLD(4), GLO1(2), HAGH(1), HAGHL(4), LDHA(1), LDHB(1), LDHC(1), LDHD(1), MDH1(1), ME1(1), ME2(3), ME3(1), PC(3), PCK1(6), PDHA1(1), PDHA2(3), PDHB(2), PKLR(3) 20729821 68 53 68 17 6 15 6 21 19 1 0.355 1.000 1.000 389 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT(3), AGXT2(1), AOC2(2), AOC3(1), ATP6V0C(2), CBS(3), CHDH(4), CHKA(1), CPT1B(4), CTH(2), DAO(7), DLD(4), DMGDH(1), GAMT(1), GARS(1), GATM(4), GCAT(3), GLDC(3), MAOA(1), MAOB(8), PLCB2(3), PLCG1(7), PLCG2(7), SARDH(3), SHMT1(2), SHMT2(4), TARS(2) 24199821 84 59 83 15 6 26 6 23 23 0 0.0406 1.000 1.000 390 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(2), CALCR(1), CD97(5), CRHR1(5), CRHR2(3), ELTD1(8), EMR1(6), EMR2(1), GHRHR(1), GIPR(1), GLP1R(3), GLP2R(3), GPR64(2), LPHN1(5), LPHN2(3), LPHN3(12), SCTR(2), VIPR1(3), VIPR2(2) 15835387 68 54 66 17 4 10 12 28 14 0 0.302 1.000 1.000 391 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(1), AKT1(2), BDKRB2(3), CAV1(1), CHRM1(3), CHRNA1(4), FLT1(4), FLT4(6), KDR(7), NOS3(9), PDE2A(1), PDE3A(8), PDE3B(2), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), PRKG1(6), PRKG2(4), RYR2(42), SYT1(2) 23947197 113 91 110 29 10 21 12 43 26 1 0.233 1.000 1.000 392 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 30 ACVR1(2), APC(12), ATF2(1), BMP2(2), BMP4(1), BMP5(4), BMP7(3), BMPR1A(1), BMPR2(5), CHRD(2), DVL1(3), FZD1(2), GSK3B(3), MAP3K7(3), MEF2C(1), NKX2-5(1), NPPB(1), RFC1(7), TGFB1(1), TGFB2(4), TGFB3(2), TGFBR1(1), TGFBR2(1), WNT1(2) 19050696 65 56 63 16 7 17 5 21 14 1 0.289 1.000 1.000 393 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 21 AKT1(2), AP2A1(1), AP2M1(2), ARF1(1), EEA1(5), GRASP(1), GSK3A(1), GSK3B(3), LYN(1), PDPK1(1), PFKL(1), PFKM(1), PFKP(2), PLCG1(7), PRKCZ(4), RPS6KB1(2) 13951933 35 28 33 9 3 11 1 9 11 0 0.630 1.000 1.000 394 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT1(1), B3GNT2(1), B3GNT4(2), B3GNT5(1), B4GALT2(1), B4GALT3(2), FUT1(4), FUT3(2), FUT5(1), FUT7(2), FUT9(4), GCNT2(1), ST3GAL6(1) 9028344 23 19 23 8 3 1 3 13 3 0 0.706 1.000 1.000 395 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(2), ADH1A(2), ADH1B(3), ADH4(3), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), DHRS1(1), DHRS3(1), DHRS7(1), ESCO1(2), ESCO2(3), NAT6(1), PNPLA3(1), SH3GLB1(2) 13836182 28 25 28 9 1 5 3 11 8 0 0.728 1.000 1.000 396 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 41 CD3G(1), FOS(1), FYN(1), JUN(2), LAT(1), LCK(4), MAP2K4(4), MAP3K1(3), MAPK8(1), NFATC1(2), NFATC2(7), NFATC3(4), NFATC4(5), NFKB1(3), NFKBIA(2), PIK3R1(4), PLCG1(7), PPP3CA(3), PPP3CB(3), PRKCA(1), RAF1(2), RASA1(10), RELA(4), SHC1(3), SOS1(8), SYT1(2), VAV1(3), ZAP70(3) 25802936 94 70 92 21 7 16 9 33 28 1 0.310 1.000 1.000 397 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(8), COL4A2(6), COL4A3(3), COL4A4(9), COL4A5(9), COL4A6(6), P4HB(1), SLC23A1(1), SLC23A2(3), SLC2A3(2) 14617073 48 39 46 16 1 9 6 20 12 0 0.449 1.000 1.000 398 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 32 CHUK(8), FOS(1), IKBKB(4), IRAK1(5), JUN(2), LY96(1), MAP2K3(2), MAP2K4(4), MAP2K6(2), MAP3K1(3), MAP3K7(3), MAPK14(3), MAPK8(1), MYD88(1), NFKB1(3), NFKBIA(2), PPARA(3), RELA(4), TIRAP(2), TLR10(3), TLR2(1), TLR3(5), TLR4(5), TLR6(4), TLR7(4), TLR9(3), TRAF6(2) 21035369 81 59 81 17 1 20 12 28 20 0 0.213 1.000 1.000 399 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 27 ADRBK1(3), AKT1(2), AKT2(3), AKT3(2), DAG1(1), GNAQ(1), ITPKA(1), ITPKB(4), ITPR1(15), ITPR2(11), ITPR3(11), NFKB1(3), NFKB2(2), NFKBIA(2), NFKBIL1(1), PDK1(1), PHKA2(3), PIK3CB(5), PITX2(1), PLD1(4), PLD2(3), PLD3(4), VN1R1(1) 26503373 84 62 82 15 8 21 5 32 18 0 0.107 1.000 1.000 400 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(1), ARG1(1), ARG2(1), ASL(1), ASS1(3), CKB(1), CKM(2), CKMT1B(1), CKMT2(2), CPS1(12), DAO(7), EPRS(4), GAMT(1), GATM(4), GLUD1(3), GLUD2(5), LAP3(3), NOS1(14), NOS3(9), OAT(2), P4HA1(2), P4HA2(1), P4HA3(1), PARS2(1), PRODH(1), PYCR1(1), RARS(3), RARS2(1) 21099059 88 68 87 22 6 22 11 27 22 0 0.259 1.000 1.000 401 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 AGXT(3), AGXT2(1), AOC2(2), AOC3(1), CBS(3), CHDH(4), CHKA(1), CTH(2), DAO(7), DLD(4), DMGDH(1), GAMT(1), GARS(1), GATM(4), GCAT(3), GLDC(3), GNMT(2), HSD3B7(1), MAOA(1), MAOB(8), PHGDH(3), PSAT1(2), RDH11(1), RDH13(1), RDH14(1), SARDH(3), SARS2(2), SDS(2), SHMT1(2), SHMT2(4), TARS(2), TARS2(4) 24639929 80 56 80 17 8 24 5 21 22 0 0.136 1.000 1.000 402 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(3), BLVRA(1), CP(6), CPOX(1), EPRS(4), FECH(1), GUSB(8), HCCS(2), HMBS(4), HMOX1(1), PPOX(3), UGT1A1(3), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A9(1), UGT2B15(1), UGT2B4(5) 15196837 51 39 50 13 1 9 1 16 24 0 0.779 1.000 1.000 403 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(3), B4GALT5(1), C1GALT1(1), C1GALT1C1(1), GALNT1(2), GALNT10(1), GALNT11(1), GALNT12(5), GALNT13(4), GALNT14(3), GALNT3(2), GALNT4(4), GALNT5(1), GALNT7(1), GALNT8(2), GALNT9(1), GALNTL5(4), GCNT3(2), GCNT4(1), OGT(3), ST3GAL1(1), ST3GAL2(1), ST6GALNAC1(2), WBSCR17(7) 18318657 54 44 53 13 9 7 8 19 11 0 0.259 1.000 1.000 404 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 AGMAT(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH4A1(1), ALDH9A1(1), AOC2(2), AOC3(1), ARG1(1), ARG2(1), ASL(1), CKB(1), CKM(2), CKMT1B(1), CKMT2(2), CPS1(12), DAO(7), GAMT(1), GATM(4), GLUD1(3), MAOA(1), MAOB(8), NOS1(14), NOS3(9), OAT(2), ODC1(3), P4HA1(2), P4HA2(1), P4HA3(1), P4HB(1), PYCR1(1), RARS(3), SMS(1) 25633051 96 71 95 19 7 21 8 36 24 0 0.0723 1.000 1.000 405 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 ASNS(3), CA1(1), CA14(1), CA4(2), CA5A(1), CA5B(1), CA6(1), CA8(1), CA9(7), CPS1(12), CTH(2), GLS(4), GLS2(1), GLUD1(3), GLUL(1) 10627182 41 36 41 12 3 11 8 11 8 0 0.446 1.000 1.000 406 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(10), ATP4A(7), ATP5A1(4), ATP5B(4), ATP5C1(1), ATP5F1(1), ATP5G2(1), ATP6AP1(2), ATP6V0A1(6), ATP6V0A2(2), ATP6V0A4(3), ATP6V0C(2), ATP6V0D1(1), ATP6V0D2(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1D(4), ATP6V1E1(1), ATP6V1F(2), ATP6V1H(1), COX10(1), COX4I2(1), COX5A(2), COX5B(2), COX6B1(2), CYC1(3), LHPP(1), NDUFA10(1), NDUFA2(1), NDUFA5(2), NDUFA7(1), NDUFA8(1), NDUFA9(1), NDUFB10(1), NDUFB3(1), NDUFB5(1), NDUFB6(1), NDUFB7(2), NDUFS1(2), NDUFS2(2), NDUFS3(1), NDUFS4(1), NDUFS6(1), NDUFV2(2), PPA1(1), SDHA(2), SDHB(1), UQCRB(1) 32178416 98 79 97 21 3 32 11 32 20 0 0.0867 1.000 1.000 407 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(8), CREBBP(6), DUSP1(1), EP300(11), IKBKB(4), IL1B(1), MAP2K3(2), MAP2K6(2), MAP3K7(3), MAPK11(1), MAPK14(3), MYD88(1), NFKB1(3), NFKBIA(2), NR3C1(3), RELA(4), TGFBR1(1), TGFBR2(1), TLR2(1), TNF(1) 16745862 59 48 58 15 1 14 7 23 14 0 0.482 1.000 1.000 408 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 50 ACTA1(1), AGT(1), AKT1(2), CAMK1(1), CAMK1G(2), CREBBP(6), CSNK1A1(2), EDN1(2), ELSPBP1(2), F2(2), GSK3B(3), HAND1(2), HAND2(2), LIF(1), MAPK1(3), MAPK14(3), MAPK8(1), MEF2C(1), MYH2(7), NFATC1(2), NFATC2(7), NFATC3(4), NFATC4(5), NKX2-5(1), PIK3R1(4), PPP3CA(3), PPP3CB(3), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), RAF1(2), RPS6KB1(2), SYT1(2) 26958680 87 63 85 20 6 24 8 31 18 0 0.161 1.000 1.000 409 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 26 CASP10(2), CASP3(3), CASP6(2), CASP8(1), CFLAR(2), DAXX(1), DFFB(1), FADD(1), FAF1(2), JUN(2), LMNA(2), LMNB2(2), MAP2K4(4), MAP3K1(3), MAP3K7(3), MAPK8(1), PAK1(3), PAK2(3), PRKDC(6), PTPN13(14), RIPK2(2), SPTAN1(7) 23261521 67 60 67 15 2 14 5 20 26 0 0.340 1.000 1.000 410 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 ALOX12B(3), ALOX15B(4), ALOX5(3), CYP2B6(5), CYP2C18(1), CYP2C8(3), CYP2C9(3), CYP2E1(4), CYP2U1(3), CYP4A11(3), CYP4A22(5), CYP4F2(1), CYP4F3(2), DHRS4(1), EPHX2(1), GGT1(1), GPX7(1), PLA2G12B(1), PLA2G2D(1), PLA2G2F(5), PLA2G3(7), PLA2G4A(8), PLA2G6(3), PTGES2(1), PTGIS(2), PTGS1(2), PTGS2(3) 22720676 77 64 75 18 10 16 6 23 22 0 0.202 1.000 1.000 411 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BET1(1), GOSR1(1), GOSR2(2), SNAP25(3), SNAP29(1), STX10(3), STX12(2), STX16(2), STX18(1), STX19(2), STX2(2), STX5(1), STX6(2), STX8(1), TSNARE1(6), USE1(1), VAMP1(3), VAMP3(1), VTI1A(2), YKT6(2) 9590566 39 33 38 11 2 9 6 13 8 1 0.485 1.000 1.000 412 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(8), IFNB1(2), IKBKB(4), IL1B(1), IL1R1(4), IL1RAP(1), IL6(2), IRAK1(5), IRAK3(3), JUN(2), MAP2K3(2), MAP2K6(2), MAP3K1(3), MAP3K7(3), MAPK14(3), MAPK8(1), MYD88(1), NFKB1(3), NFKBIA(2), RELA(4), TGFB1(1), TGFB2(4), TGFB3(2), TNF(1), TRAF6(2) 16759493 66 54 66 17 2 17 9 23 15 0 0.416 1.000 1.000 413 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 21 ADCY1(5), AKT1(2), BAX(3), BCL2(1), CSF2RB(2), IGF1R(11), KIT(12), KITLG(2), PIK3R1(4), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3) 11137755 50 36 48 15 5 10 4 16 15 0 0.598 1.000 1.000 414 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(1), DCXR(1), GUSB(8), UGDH(2), UGP2(3), UGT1A1(3), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A9(1), UGT2A1(2), UGT2B11(1), UGT2B15(1), UGT2B17(1), UGT2B28(1), UGT2B4(5), UGT2B7(5), XYLB(1) 14332604 43 32 41 12 0 8 1 13 21 0 0.917 1.000 1.000 415 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(6), GABBR1(7), GPRC5A(1), GPRC5C(1), GRM1(4), GRM2(2), GRM3(4), GRM4(4), GRM5(5), GRM7(3), GRM8(7) 11662443 44 37 44 13 6 8 4 20 6 0 0.407 1.000 1.000 416 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ACY3(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3B1(1), ALDH3B2(1), ALDH7A1(1), ALDH9A1(1), AMDHD1(2), AOC2(2), AOC3(1), DDC(2), FTCD(3), HARS(1), HARS2(1), HDC(4), HEMK1(3), LCMT2(3), MAOA(1), MAOB(8), METTL2B(5), METTL6(3), PRMT2(1), PRMT3(1), PRMT5(2), PRMT6(3), PRMT7(1), PRMT8(3), PRPS1(1), UROC1(3), WBSCR22(2) 22537379 66 50 66 14 6 16 6 22 15 1 0.186 1.000 1.000 417 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(3), CS(4), DLD(4), DLST(1), FH(3), IDH2(4), IDH3G(2), MDH1(1), OGDH(1), PC(3), PDHA1(1), PDHA2(3), PDHB(2), PDHX(3), PDK1(1), PDK2(1), PDK3(1), PDK4(2), SDHA(2), SDHB(1), SUCLA2(2), SUCLG1(1), SUCLG2(1) 16140321 47 40 46 13 3 8 7 13 16 0 0.432 1.000 1.000 418 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(5), CD3G(1), CD4(1), CREBBP(6), CSK(1), GNAS(10), GNB1(2), HLA-DRA(1), HLA-DRB1(1), LCK(4), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), PTPRC(8), ZAP70(3) 13162957 51 39 48 13 6 12 4 21 8 0 0.499 1.000 1.000 419 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(5), CD3G(1), CD4(1), CREBBP(6), CSK(1), GNAS(10), GNB1(2), HLA-DRA(1), HLA-DRB1(1), LCK(4), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), PTPRC(8), ZAP70(3) 13162957 51 39 48 13 6 12 4 21 8 0 0.499 1.000 1.000 420 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACADL(2), ACADM(1), ACOX1(2), ACOX2(3), ACOX3(1), ACSL1(1), ACSL3(2), ACSL5(1), ACSL6(3), ADIPOQ(3), ANGPTL4(2), APOA1(2), APOA2(1), APOA5(1), CD36(3), CPT1A(4), CPT1B(4), CPT2(1), CYP27A1(4), CYP4A11(3), CYP4A22(5), CYP7A1(1), CYP8B1(4), EHHADH(10), FABP1(1), FABP2(1), FABP7(1), GK(1), GK2(1), HMGCS2(2), LPL(1), ME1(1), MMP1(2), NR1H3(4), PCK1(6), PCK2(1), PDPK1(1), PLTP(4), PPARA(3), PPARG(1), RXRA(2), RXRB(8), RXRG(2), SCD(2), SCP2(3), SLC27A1(1), SLC27A4(1), SLC27A5(3), SLC27A6(2), SORBS1(1), UBC(1), UCP1(4) 37014167 125 91 123 29 11 17 21 45 30 1 0.114 1.000 1.000 421 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 48 ACOX1(2), APOA1(2), APOA2(1), CD36(3), CITED2(2), CPT1B(4), CREBBP(6), DUSP1(1), DUT(1), EHHADH(10), EP300(11), FABP1(1), HSD17B4(1), INS(1), JUN(2), LPL(1), MAPK1(3), ME1(1), MRPL11(1), MYC(2), NCOA1(5), NCOR1(10), NCOR2(14), NFKBIA(2), NR0B2(4), NR1H3(4), NR2F1(2), NRIP1(1), PDGFA(2), PIK3R1(4), PPARA(3), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), PRKCA(1), PTGS2(3), RELA(4), RXRA(2), SP1(2), STAT5A(2), STAT5B(1), TNF(1) 34112720 131 87 128 28 10 23 17 47 32 2 0.120 1.000 1.000 422 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(3), CD33(1), CD5(1), CD7(1), IFNB1(2), IFNG(3), IL10(1), IL12A(6), IL12B(2), IL4(1), IL5(1), ITGAX(2), TLR2(1), TLR4(5), TLR7(4), TLR9(3) 10414269 37 32 37 11 0 7 6 19 5 0 0.497 1.000 1.000 423 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(2), CD3G(1), CXCR3(3), ETV5(2), IFNG(3), IL12A(6), IL12B(2), IL12RB1(3), IL12RB2(5), IL18(2), IL18R1(2), JAK2(4), JUN(2), MAP2K6(2), MAPK14(3), MAPK8(1), STAT4(4), TYK2(1) 10604960 48 41 48 14 3 9 8 17 11 0 0.471 1.000 1.000 424 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(2), ACAT1(2), ACAT2(5), ACMSD(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH9A1(1), AOC2(2), AOC3(1), AOX1(11), CAT(1), CYP19A1(1), CYP1A1(3), CYP2A13(2), CYP2A6(3), CYP2A7(4), CYP2B6(5), CYP2C18(1), CYP2C8(3), CYP2C9(3), CYP2D6(1), CYP2E1(4), CYP2F1(1), CYP3A4(1), CYP3A5(4), CYP4B1(6), DDC(2), ECHS1(2), EHHADH(10), GCDH(1), HAAO(1), HADHA(3), KMO(1), KYNU(3), MAOA(1), MAOB(8), SDS(2), TPH1(2), WARS(2), WARS2(1) 30965580 114 82 114 27 3 31 11 36 33 0 0.174 1.000 1.000 425 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(9), BCL2(1), BIRC2(4), BIRC3(1), CASP10(2), CASP3(3), CASP6(2), CASP8(1), CASP9(1), CFLAR(2), CHUK(8), DFFB(1), FADD(1), GAS2(1), LMNA(2), NFKB1(3), NFKBIA(2), RELA(4), RIPK1(4), SPTAN1(7), TNFRSF10B(2), TNFRSF25(2), TNFSF10(1) 18994906 64 50 64 16 2 21 6 14 21 0 0.442 1.000 1.000 426 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 28 BAG4(1), BIRC2(4), BIRC3(1), CASP3(3), CASP8(1), CFLAR(2), FADD(1), JUN(2), MAP2K4(4), MAP3K3(1), MAP3K7(3), NFKB1(3), NFKB2(2), NFKBIA(2), NFKBIL1(1), NR2C2(2), RALBP1(1), RIPK1(4), TNF(1), TNFAIP3(1), TNFRSF1A(1), TNFRSF1B(1) 16319588 42 38 42 11 1 13 5 10 13 0 0.618 1.000 1.000 427 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(2), AKT2(3), AKT3(2), ASAH1(2), DAG1(1), DRD2(4), EGFR(6), EPHB2(4), ITPKA(1), ITPKB(4), ITPR1(15), ITPR2(11), ITPR3(11), KCNJ3(3), MAPK1(3), PIK3CB(5), PITX2(1), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(9), RAF1(2), RGS20(1), SHC1(3), SOS1(8), SOS2(4), SRC(3), STAT3(4), TERF2IP(1) 33391631 128 93 123 27 11 32 9 49 26 1 0.152 1.000 1.000 428 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(1), AOC2(2), AOC3(1), CES1(3), DDHD1(2), ESCO1(2), ESCO2(3), LIPA(1), NAT6(1), PLA1A(2), PNPLA3(1), PRDX6(1), SH3GLB1(2) 14222637 22 19 22 9 2 5 3 9 3 0 0.660 1.000 1.000 429 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 92 ANK2(15), B3GALT4(1), CDR1(1), DGKI(5), MRPL19(1), RPL11(3), RPL13(2), RPL18(1), RPL18A(3), RPL19(1), RPL21(1), RPL22(1), RPL23(1), RPL27(1), RPL28(1), RPL3(3), RPL35A(1), RPL37(1), RPL4(1), RPL5(1), RPL7A(3), RPL8(1), RPL9(1), RPLP0(1), RPS10(1), RPS13(1), RPS2(1), RPS23(1), RPS27(1), RPS27A(1), RPS3(2), RPS3A(2), RPS4Y1(1), RPS6(2), RPS6KA1(1), RPS6KA2(5), RPS6KA6(8), RPS6KB1(2), RPS6KB2(4), RPS7(1), RPS9(1), SLC36A2(3), TSPAN9(1), UBA52(1), UBC(1) 27497119 92 70 90 19 9 21 11 30 21 0 0.0961 1.000 1.000 430 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(8), AP2A1(1), AP2M1(2), BIN1(4), EPN1(3), EPS15(1), NME1(2), NME2(1), PICALM(1), PPP3CA(3), PPP3CB(3), SYNJ1(7), SYNJ2(3), SYT1(2) 12955306 41 36 40 13 5 8 4 13 11 0 0.622 1.000 1.000 431 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(3), ALDH4A1(1), ALDH5A1(1), CAD(4), CPS1(12), EPRS(4), GAD1(5), GAD2(1), GCLC(1), GCLM(1), GFPT1(1), GFPT2(2), GLS(4), GLS2(1), GLUD1(3), GLUD2(5), GLUL(1), GMPS(4), GNPNAT1(1), GPT(1), GPT2(2), GSR(3), GSS(1), NAGK(3), PPAT(4), QARS(1) 22347634 70 47 69 17 2 21 9 18 20 0 0.217 1.000 1.000 432 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(3), ACACA(10), ACADL(2), ACADM(1), ACAT1(2), ACAT2(5), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH6A1(1), ALDH9A1(1), ECHS1(2), EHHADH(10), HADHA(3), LDHA(1), LDHB(1), LDHC(1), MUT(4), PCCA(1), PCCB(1), SDS(2), SUCLA2(2), SUCLG1(1), SUCLG2(1) 18698676 62 44 62 17 1 15 6 19 21 0 0.485 1.000 1.000 433 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 21 ARFIP2(2), CFL1(1), CHN1(1), LIMK1(4), MAP3K1(3), MYLK(3), NCF2(1), PAK1(3), PDGFRA(5), PIK3R1(4), PLD1(4), PPP1R12B(4), RALBP1(1), RPS6KB1(2), TRIO(6), VAV1(3), WASF1(1) 18554186 48 39 47 12 4 11 3 20 10 0 0.450 1.000 1.000 434 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 AGMAT(1), ALDH18A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), AOC2(2), AOC3(1), ARG1(1), ARG2(1), ASL(1), ASS1(3), CPS1(12), GATM(4), MAOA(1), MAOB(8), NAGS(1), ODC1(3), SMS(1), SRM(2) 16706548 50 40 49 13 2 11 5 18 14 0 0.341 1.000 1.000 435 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 AZIN1(3), BTG1(1), CBX3(2), CLDN5(1), CLOCK(1), CRY1(1), CRY2(1), DAZAP2(1), DNAJA1(1), EIF4G2(4), ETV6(1), GFRA1(2), GSTM3(1), GSTP1(2), HSPA8(2), IDI1(1), KLF9(3), MYF6(1), NCKAP1(3), NCOA4(2), NR1D2(1), PER1(6), PER2(4), PPP1R3C(1), PPP2CB(1), PSMA4(2), SF3A3(3), TOB1(4), TUBB3(1), UGP2(3), VAPA(1), ZFR(2) 20739295 63 53 61 15 5 16 7 21 13 1 0.270 1.000 1.000 436 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 40 AKT1(2), ASAH1(2), CAMP(1), CREB1(1), CREB5(2), CREBBP(6), DAG1(1), EGR2(1), EGR3(2), EGR4(1), GNAQ(1), JUN(2), MAP1B(15), MAP2K4(4), MAP2K7(2), MAPK1(3), MAPK10(3), MAPK8(1), MAPK8IP1(1), MAPK8IP3(2), MAPK9(3), NTRK1(5), PIK3C2G(7), PIK3CD(5), PIK3R1(4), PTPN11(4), SHC1(3), SRC(3), TERF2IP(1), TH(1) 28039889 89 64 89 22 8 20 7 28 25 1 0.296 1.000 1.000 437 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(3), ACACA(10), ACACB(10), ACADM(1), ACAT1(2), ACAT2(5), ACSS1(2), ACSS2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH6A1(1), ALDH7A1(1), ALDH9A1(1), ECHS1(2), EHHADH(10), HADHA(3), HIBCH(6), LDHA(1), LDHAL6A(2), LDHAL6B(2), LDHB(1), LDHC(1), MUT(4), PCCA(1), PCCB(1), SUCLA2(2), SUCLG1(1), SUCLG2(1) 22375656 80 57 79 22 2 21 9 27 21 0 0.345 1.000 1.000 438 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(2), ACAT2(5), ACOT11(1), ACYP1(1), DHRS1(1), DHRS3(1), DHRS7(1), ECHS1(2), EHHADH(10), ESCO1(2), ESCO2(3), FN3K(1), GCDH(1), HADHA(3), NAT6(1), PNPLA3(1), SH3GLB1(2) 14465877 38 28 38 11 1 8 6 16 7 0 0.456 1.000 1.000 439 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(1), ALG10B(3), ALG11(1), ALG13(1), ALG14(1), ALG2(1), ALG5(3), ALG6(1), ALG8(1), ALG9(1), B4GALT2(1), B4GALT3(2), DDOST(1), DOLPP1(1), DPM1(1), FUT8(2), GANAB(3), MAN1A1(3), MAN1A2(3), MAN1B1(1), MAN1C1(1), MAN2A1(8), MGAT1(3), MGAT2(2), MGAT3(4), MGAT4A(2), MGAT5(4), MGAT5B(3), RFT1(2), RPN1(1), RPN2(2), ST6GAL1(1), STT3B(4) 24422455 69 47 69 15 3 22 6 24 13 1 0.158 1.000 1.000 440 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(1), ADCY1(5), CCNB1(2), CDC25C(3), GNAI1(4), GNAS(10), GNB1(2), MAPK1(3), MYT1(2), PIN1(2), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), RPS6KA1(1), SRC(3) 11883513 46 39 42 13 7 12 4 16 7 0 0.535 1.000 1.000 441 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 22 IMPA1(2), INPP4A(1), INPP4B(6), INPP5A(3), INPPL1(1), ITPKA(1), ITPKB(4), MIOX(1), OCRL(4), PIK3C2A(4), PIK3C2B(8), PIK3C2G(7), PIK3CB(5), PIK3CG(3), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(9), PLCD1(2), PLCG1(7), PLCG2(7) 24551358 90 64 86 22 5 22 10 26 27 0 0.316 1.000 1.000 442 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 61 ATM(9), CCNA1(3), CCNB1(2), CCND1(1), CCND2(3), CCNE1(1), CCNE2(2), CCNH(1), CDKN1B(5), CDKN1C(2), CDKN2B(1), CDKN2C(2), CREB3L1(2), CREB3L3(5), CREB3L4(3), E2F1(3), E2F3(2), E2F4(2), E2F6(2), GBA2(1), MCM2(5), MCM3(4), MCM4(3), MCM5(2), MCM6(2), MCM7(7), MDM2(1), MYC(2), MYT1(2), NACA(5), POLE(4), POLE2(4), PRIM1(3), RBL1(4), RPA1(1), RPA2(2), TFDP1(2), TFDP2(3), TNXB(12), WEE1(2) 42348059 122 85 117 24 5 23 12 50 31 1 0.0241 1.000 1.000 443 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(2), ABAT(3), ACAT1(2), ACAT2(5), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH5A1(1), ALDH9A1(1), ECHS1(2), EHHADH(10), GAD1(5), GAD2(1), HADHA(3), HMGCL(2), L2HGDH(2), OXCT1(2), PDHA1(1), PDHA2(3), PDHB(2), SDHB(1), SDS(2) 14579310 57 44 56 18 2 12 7 25 11 0 0.630 1.000 1.000 444 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 33 GTF2A1(2), GTF2A1L(1), GTF2B(3), GTF2E1(3), GTF2F1(1), GTF2H4(3), GTF2I(2), GTF2IRD1(1), STON1(6), TAF1(8), TAF10(1), TAF1L(6), TAF2(5), TAF4(1), TAF4B(4), TAF6(4), TAF6L(1), TAF7L(2), TAF9B(3), TBPL1(2), TBPL2(1) 20973990 60 49 58 15 3 20 8 16 11 2 0.193 1.000 1.000 445 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 26 BRCA1(9), CCND1(1), CREBBP(6), EP300(11), ERCC3(3), ESR1(6), GRIP1(6), GTF2A1(2), GTF2E1(3), GTF2F1(1), HDAC2(3), HDAC4(7), HDAC5(4), HDAC6(7), MEF2C(1), NCOR2(14), NR0B1(3), NRIP1(1), PELP1(5), POLR2A(7), TBP(1) 27171547 101 76 97 28 9 27 12 30 21 2 0.222 1.000 1.000 446 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(9), BAX(3), BCL2(1), BIRC2(4), BIRC3(1), BNIP3L(1), CASP10(2), CASP3(3), CASP4(3), CASP6(2), CASP8(1), CASP9(1), CHUK(8), DFFB(1), FADD(1), FAS(3), GZMB(2), HELLS(5), IKBKB(4), IRF1(1), IRF2(5), IRF3(1), IRF4(2), IRF5(1), IRF6(1), IRF7(1), JUN(2), MAP2K4(4), MAP3K1(3), MAPK10(3), MDM2(1), MYC(2), NFKB1(3), NFKBIA(2), PLEKHG5(2), PRF1(4), RELA(4), RIPK1(4), TNF(1), TNFRSF10B(2), TNFRSF1A(1), TNFRSF1B(1), TNFRSF21(4), TNFRSF25(2), TNFSF10(1), TP73(2), TRAF1(1), TRAF3(1) 32781504 117 89 116 29 10 31 12 29 35 0 0.292 1.000 1.000 447 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(9), BAX(3), BCL2(1), CASP10(2), CASP3(3), CASP4(3), CASP6(2), CASP8(1), CASP9(1), CD40(3), CRADD(1), DAXX(1), DFFB(1), FADD(1), FAS(3), IKBKE(1), MCL1(2), NFKB1(3), NFKBIA(2), NGFR(3), NR3C1(3), NTRK1(5), PTPN13(14), RIPK1(4), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRAF1(1), TRAF3(1), TRAF6(2) 24864870 79 66 78 21 5 27 7 21 19 0 0.360 1.000 1.000 448 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(3), ACAA2(1), ACADM(1), ACAT1(2), ACAT2(5), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH6A1(1), ALDH7A1(1), ALDH9A1(1), AOX1(11), BCAT1(2), BCAT2(1), BCKDHA(1), DBT(2), DLD(4), ECHS1(2), EHHADH(10), HADH(1), HADHA(3), HADHB(4), HIBADH(1), HIBCH(6), HMGCL(2), HMGCS1(2), HMGCS2(2), HSD17B4(1), IVD(1), MCCC1(5), MCCC2(2), MUT(4), OXCT1(2), PCCA(1), PCCB(1) 24812374 91 56 89 26 2 28 9 30 22 0 0.373 1.000 1.000 449 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(2), ACTG1(1), ARHGEF2(5), ARPC5L(1), CDC42(3), CDH1(7), CLDN1(1), CTTN(3), EZR(1), FYN(1), HCLS1(2), KRT18(1), LY96(1), NCK1(1), NCK2(2), NCL(6), OCLN(3), PRKCA(1), ROCK1(6), ROCK2(3), TLR4(5), TLR5(1), TUBA1A(1), TUBA3C(2), TUBA3D(2), TUBA3E(4), TUBA4A(3), TUBA8(2), TUBAL3(1), TUBB(1), TUBB1(2), TUBB2A(1), TUBB2B(1), TUBB3(1), TUBB6(2), TUBB8(2), WASL(2), YWHAZ(1) 28657945 85 67 83 20 5 12 9 38 21 0 0.328 1.000 1.000 450 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(2), ACTG1(1), ARHGEF2(5), ARPC5L(1), CDC42(3), CDH1(7), CLDN1(1), CTTN(3), EZR(1), FYN(1), HCLS1(2), KRT18(1), LY96(1), NCK1(1), NCK2(2), NCL(6), OCLN(3), PRKCA(1), ROCK1(6), ROCK2(3), TLR4(5), TLR5(1), TUBA1A(1), TUBA3C(2), TUBA3D(2), TUBA3E(4), TUBA4A(3), TUBA8(2), TUBAL3(1), TUBB(1), TUBB1(2), TUBB2A(1), TUBB2B(1), TUBB3(1), TUBB6(2), TUBB8(2), WASL(2), YWHAZ(1) 28657945 85 67 83 20 5 12 9 38 21 0 0.328 1.000 1.000 451 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 20 ATM(9), ATR(15), BRCA1(9), BRCA2(10), CHEK1(5), CHEK2(5), FANCA(4), FANCC(1), FANCD2(3), FANCE(3), FANCF(3), FANCG(1), HUS1(1), RAD1(1), RAD17(1), RAD50(6), RAD51(2), RAD9A(2), TREX1(1) 24114198 82 59 82 19 5 17 9 32 17 2 0.283 1.000 1.000 452 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(2), CDC42(3), CREB1(1), CREB5(2), DUSP1(1), EEF2K(1), HSPB1(1), IL1R1(4), MAP2K3(2), MAP2K4(4), MAP2K6(2), MAP3K10(1), MAP3K4(9), MAP3K5(1), MAP3K7(3), MAPK1(3), MAPK11(1), MAPK12(1), MAPK14(3), MAPKAPK2(1), MAPKAPK5(3), MKNK1(2), MKNK2(3), MYEF2(3), NFKB1(3), NR2C2(2), SRF(1), TRAF6(2) 19528172 65 55 65 19 8 17 9 14 16 1 0.474 1.000 1.000 453 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(5), ADCY3(2), ADCY4(4), ADCY7(1), ADCY8(9), ADCY9(6), ADORA2A(2), ADORA2B(1), ADRA1B(1), ADRA1D(4), ADRB2(3), ADRB3(1), AGTR1(2), ATP2A1(1), ATP2A2(7), ATP2A3(2), ATP2B1(5), ATP2B2(10), ATP2B3(4), ATP2B4(3), AVPR1A(3), AVPR1B(2), BDKRB2(3), BST1(1), CACNA1A(9), CACNA1B(13), CACNA1C(9), CACNA1D(6), CACNA1E(33), CACNA1F(3), CACNA1G(9), CACNA1H(7), CACNA1I(6), CACNA1S(6), CALML6(2), CAMK2A(6), CAMK2B(2), CAMK2G(3), CCKAR(1), CCKBR(3), CD38(3), CHRM1(3), CHRM2(5), CHRM3(7), CHRM5(2), CHRNA7(1), CYSLTR1(2), CYSLTR2(3), DRD1(1), EDNRA(1), EDNRB(2), EGFR(6), ERBB2(4), ERBB3(8), ERBB4(11), F2R(1), GNA15(1), GNAL(2), GNAQ(1), GNAS(10), GRIN1(5), GRIN2A(6), GRIN2C(5), GRIN2D(2), GRM1(4), GRM5(5), GRPR(1), HRH1(2), HTR2C(3), HTR5A(2), HTR6(1), HTR7(5), ITPKA(1), ITPKB(4), ITPR1(15), ITPR2(11), ITPR3(11), LHCGR(6), MYLK(3), MYLK2(2), NOS1(14), NOS3(9), OXTR(1), P2RX1(2), P2RX2(1), P2RX3(3), P2RX4(1), P2RX7(1), PDE1A(2), PDE1B(2), PDE1C(9), PDGFRA(5), PDGFRB(1), PHKA1(6), PHKA2(3), PHKB(8), PHKG2(2), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(9), PLCD1(2), PLCD3(1), PLCD4(3), PLCE1(5), PLCG1(7), PLCG2(7), PLCZ1(3), PPP3CA(3), PPP3CB(3), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(1), PRKCG(4), PRKX(3), PTGER1(1), PTGER3(7), PTGFR(2), PTK2B(5), RYR1(31), RYR2(42), RYR3(21), SLC25A4(1), SLC25A5(1), SLC25A6(2), SLC8A1(6), SLC8A2(2), SLC8A3(1), SPHK1(7), SPHK2(3), TACR1(2), TACR2(2), TACR3(4), TNNC2(2), TRHR(3), TRPC1(5), VDAC1(2) 158206843 662 262 644 189 66 154 54 251 135 2 0.298 1.000 1.000 454 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 189 ACTG1(1), ACTN1(4), ACTN2(6), ACTN4(2), AKT1(2), AKT2(3), AKT3(2), ARHGAP5(3), BCAR1(3), BCL2(1), BIRC2(4), BIRC3(1), CAPN2(1), CAV1(1), CAV2(1), CCND1(1), CCND2(3), CDC42(3), COL11A1(21), COL11A2(10), COL1A1(6), COL1A2(8), COL2A1(9), COL3A1(8), COL4A1(8), COL4A2(6), COL4A4(9), COL4A6(6), COL5A1(14), COL5A2(5), COL5A3(9), COL6A1(6), COL6A2(4), COL6A3(18), COL6A6(16), COMP(5), DIAPH1(5), DOCK1(7), EGF(6), EGFR(6), ERBB2(4), FARP2(4), FIGF(1), FLNA(4), FLNB(10), FLNC(5), FLT1(4), FN1(13), FYN(1), GSK3B(3), HGF(7), IBSP(2), IGF1R(11), ITGA1(5), ITGA10(7), ITGA11(6), ITGA2(4), ITGA2B(3), ITGA3(5), ITGA4(5), ITGA5(4), ITGA6(3), ITGA7(6), ITGA8(1), ITGA9(5), ITGAV(3), ITGB3(5), ITGB4(9), ITGB5(7), ITGB6(4), ITGB7(1), ITGB8(5), JUN(2), KDR(7), LAMA1(17), LAMA2(13), LAMA3(14), LAMA4(3), LAMA5(13), LAMB1(5), LAMB2(8), LAMB3(6), LAMB4(7), LAMC1(6), LAMC2(6), LAMC3(3), MAPK1(3), MAPK10(3), MAPK8(1), MAPK9(3), MET(2), MYLK(3), MYLK2(2), PAK1(3), PAK2(3), PAK3(3), PAK4(2), PAK6(2), PAK7(10), PARVA(1), PARVB(1), PDGFA(2), PDGFB(1), PDGFC(3), PDGFD(3), PDGFRA(5), PDGFRB(1), PDPK1(1), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIK3R1(4), PIK3R2(4), PIK3R3(2), PIK3R5(1), PPP1CA(2), PPP1CC(1), PPP1R12A(2), PRKCA(1), PRKCG(4), PTK2(9), PXN(2), RAC3(1), RAF1(2), RAP1A(2), RAPGEF1(8), RELN(12), ROCK1(6), ROCK2(3), SHC1(3), SHC4(4), SOS1(8), SOS2(4), SRC(3), THBS1(6), THBS2(5), THBS3(6), THBS4(2), TLN1(10), TLN2(9), TNC(7), TNN(8), TNR(11), TNXB(12), VASP(2), VAV1(3), VAV3(8), VCL(3), VEGFA(1), VEGFC(6), VTN(1), VWF(7), ZYX(2) 211404804 769 258 761 209 52 172 79 266 192 8 0.101 1.000 1.000 455 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 245 ACVR1B(2), ACVR1C(1), AKT1(2), AKT2(3), AKT3(2), ARRB1(2), ARRB2(1), ATF2(1), ATF4(4), BDNF(1), CACNA1A(9), CACNA1B(13), CACNA1C(9), CACNA1D(6), CACNA1E(33), CACNA1F(3), CACNA1G(9), CACNA1H(7), CACNA1I(6), CACNA1S(6), CACNA2D1(10), CACNA2D2(6), CACNA2D3(5), CACNA2D4(5), CACNB1(2), CACNB2(1), CACNB4(5), CACNG2(4), CACNG3(2), CACNG4(2), CACNG5(1), CACNG6(1), CACNG7(2), CACNG8(2), CASP3(3), CDC25B(2), CDC42(3), CHUK(8), DAXX(1), DUSP1(1), DUSP14(1), DUSP16(1), DUSP4(1), DUSP5(1), DUSP6(2), DUSP7(1), DUSP8(2), DUSP9(1), ECSIT(2), EGF(6), EGFR(6), FAS(3), FGF12(1), FGF14(1), FGF20(3), FGF21(1), FGF23(1), FGF3(1), FGF5(2), FGF6(1), FGF7(1), FGF8(1), FGF9(1), FGFR1(2), FGFR2(4), FGFR3(3), FGFR4(6), FLNA(4), FLNB(10), FLNC(5), FOS(1), GADD45G(1), GNA12(1), GNG12(1), IKBKB(4), IL1B(1), IL1R1(4), IL1R2(1), JUN(2), JUND(1), MAP2K2(2), MAP2K3(2), MAP2K4(4), MAP2K5(1), MAP2K6(2), MAP2K7(2), MAP3K1(3), MAP3K10(1), MAP3K12(2), MAP3K13(4), MAP3K2(5), MAP3K3(1), MAP3K4(9), MAP3K5(1), MAP3K6(1), MAP3K7(3), MAP3K8(1), MAP4K1(1), MAP4K2(4), MAP4K3(1), MAP4K4(4), MAPK1(3), MAPK10(3), MAPK11(1), MAPK12(1), MAPK14(3), MAPK7(3), MAPK8(1), MAPK8IP1(1), MAPK8IP3(2), MAPK9(3), MAPKAPK2(1), MAPKAPK3(1), MAPKAPK5(3), MAPT(6), MEF2C(1), MKNK1(2), MKNK2(3), MOS(2), MYC(2), NF1(14), NFATC2(7), NFATC4(5), NFKB1(3), NFKB2(2), NLK(2), NR4A1(3), NRAS(3), NTF3(1), NTRK1(5), NTRK2(6), PAK1(3), PAK2(3), PDGFA(2), PDGFB(1), PDGFRA(5), PDGFRB(1), PLA2G12B(1), PLA2G2D(1), PLA2G2F(5), PLA2G3(7), PLA2G4A(8), PLA2G6(3), PPM1B(1), PPP3CA(3), PPP3CB(3), PPP5C(4), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(1), PRKCG(4), PRKX(3), PTPN5(4), PTPRR(2), RAC3(1), RAF1(2), RAP1A(2), RAPGEF2(7), RASA1(10), RASA2(2), RASGRF1(6), RASGRF2(5), RASGRP1(5), RASGRP3(1), RASGRP4(3), RPS6KA1(1), RPS6KA2(5), RPS6KA4(2), RPS6KA5(5), RPS6KA6(8), SOS1(8), SOS2(4), SRF(1), STK3(6), STK4(1), STMN1(1), TAOK1(5), TAOK2(4), TAOK3(4), TGFB1(1), TGFB2(4), TGFB3(2), TGFBR1(1), TGFBR2(1), TNF(1), TNFRSF1A(1), TRAF6(2), ZAK(3) 168605444 611 238 600 174 63 130 70 205 140 3 0.151 1.000 1.000 456 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 133 ACTG1(1), COL11A1(21), COL11A2(10), COL17A1(5), COL1A1(6), COL1A2(8), COL2A1(9), COL3A1(8), COL4A1(8), COL4A2(6), COL4A4(9), COL4A6(6), COL5A1(14), COL5A2(5), COL5A3(9), COL6A1(6), COL6A2(4), COL6A3(18), COL6A6(16), COMP(5), DES(3), DSC1(2), DSC2(4), DSC3(1), DSG1(1), DSG2(2), DSG3(5), DSG4(7), FN1(13), GJA1(1), GJA10(1), GJA4(1), GJA5(3), GJA8(6), GJB2(1), GJB4(2), GJB5(1), GJB6(2), GJB7(1), GJC1(2), GJC2(2), GJD2(2), GJD4(2), IBSP(2), INA(1), ITGA6(3), ITGB4(9), KRT1(7), KRT12(1), KRT13(2), KRT14(1), KRT15(3), KRT16(3), KRT17(2), KRT18(1), KRT19(1), KRT20(5), KRT23(1), KRT24(3), KRT27(4), KRT28(2), KRT3(1), KRT31(3), KRT32(4), KRT33A(2), KRT33B(2), KRT34(5), KRT35(4), KRT36(2), KRT37(2), KRT38(5), KRT39(2), KRT4(1), KRT40(5), KRT5(4), KRT6A(3), KRT6B(2), KRT6C(2), KRT7(3), KRT71(3), KRT73(2), KRT74(1), KRT75(3), KRT76(2), KRT77(1), KRT78(1), KRT79(5), KRT81(4), KRT83(3), KRT84(2), KRT85(3), KRT86(2), KRT9(3), LAMA1(17), LAMA2(13), LAMA3(14), LAMA4(3), LAMA5(13), LAMB1(5), LAMB2(8), LAMB3(6), LAMB4(7), LAMC1(6), LAMC2(6), LAMC3(3), LMNA(2), LMNB2(2), NES(8), RELN(12), THBS1(6), THBS2(5), THBS3(6), THBS4(2), TNC(7), TNN(8), TNR(11), TNXB(12), VIM(4), VTN(1), VWF(7) 141699090 571 228 566 166 43 102 61 223 134 8 0.259 1.000 1.000 457 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 234 ADCYAP1R1(2), ADORA1(1), ADORA2A(2), ADORA2B(1), ADORA3(2), ADRA1B(1), ADRA2B(1), ADRA2C(1), ADRB2(3), ADRB3(1), AGTR1(2), AVPR1A(3), AVPR1B(2), AVPR2(1), BDKRB2(3), C3AR1(1), CALCR(1), CCKAR(1), CCKBR(3), CGA(1), CHRM1(3), CHRM2(5), CHRM3(7), CHRM4(2), CHRM5(2), CNR1(3), CNR2(1), CRHR1(5), CRHR2(3), CTSG(1), CYSLTR1(2), CYSLTR2(3), DRD1(1), DRD2(4), DRD3(2), DRD5(1), EDNRA(1), EDNRB(2), F2(2), F2R(1), F2RL3(1), FPR1(1), FSHR(4), GABBR1(7), GABBR2(3), GABRA1(5), GABRA2(7), GABRA3(1), GABRA4(6), GABRA5(4), GABRA6(7), GABRB1(4), GABRB2(2), GABRB3(3), GABRG1(10), GABRG2(4), GABRG3(3), GABRP(1), GABRQ(8), GABRR1(2), GABRR2(2), GALR2(1), GH1(1), GH2(3), GHR(3), GHRHR(1), GHSR(2), GIPR(1), GLP1R(3), GLP2R(3), GLRA1(2), GLRA2(2), GLRA3(1), GLRB(1), GPR156(4), GPR35(2), GPR50(2), GPR63(7), GPR83(4), GRIA1(10), GRIA2(9), GRIA3(6), GRIA4(11), GRID1(5), GRID2(4), GRIK1(5), GRIK2(7), GRIK3(4), GRIK4(4), GRIK5(2), GRIN1(5), GRIN2A(6), GRIN2B(3), GRIN2C(5), GRIN2D(2), GRIN3A(6), GRIN3B(3), GRM1(4), GRM2(2), GRM3(4), GRM4(4), GRM5(5), GRM7(3), GRM8(7), GRPR(1), GZMA(3), HCRTR1(1), HCRTR2(2), HRH1(2), HRH3(2), HRH4(1), HTR1A(2), HTR1B(1), HTR1D(1), HTR1E(3), HTR1F(1), HTR2C(3), HTR5A(2), HTR6(1), HTR7(5), KISS1R(1), LEP(2), LEPR(4), LHB(2), LHCGR(6), LTB4R(1), MC2R(3), MC3R(2), MC4R(2), MC5R(1), MCHR1(1), MCHR2(1), MTNR1A(2), MTNR1B(3), NMBR(1), NMUR1(3), NMUR2(6), NPBWR2(3), NPFFR1(1), NPFFR2(4), NPY1R(3), NPY2R(4), NPY5R(5), NR3C1(3), NTSR2(3), OPRK1(3), OPRL1(2), OPRM1(4), OXTR(1), P2RX1(2), P2RX2(1), P2RX3(3), P2RX4(1), P2RX7(1), P2RY1(4), P2RY10(3), P2RY13(1), P2RY14(1), P2RY2(1), P2RY4(2), P2RY6(1), P2RY8(1), PARD3(3), PRL(3), PRLHR(2), PRLR(1), PRSS1(2), PRSS3(1), PTGER1(1), PTGER2(3), PTGER3(7), PTGER4(1), PTGFR(2), PTGIR(2), PTH2R(4), RXFP1(4), RXFP2(1), SCTR(2), SSTR2(1), SSTR4(3), SSTR5(3), TAAR1(1), TAAR2(3), TAAR5(1), TACR1(2), TACR2(2), TACR3(4), TRHR(3), TRPV1(2), TSHR(2), TSPO(1), UTS2R(1), VIPR1(3), VIPR2(2) 125270912 541 225 527 151 49 93 59 243 97 0 0.157 1.000 1.000 458 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 201 ABI2(2), ACTN1(4), ACTN2(6), ACTN4(2), APC(12), APC2(3), ARAF(5), ARHGEF1(1), ARHGEF12(8), ARHGEF4(4), ARHGEF6(3), ARHGEF7(4), ARPC1A(1), ARPC1B(2), ARPC2(3), ARPC3(1), ARPC5L(1), BAIAP2(1), BCAR1(3), BDKRB2(3), CDC42(3), CFL1(1), CFL2(2), CHRM1(3), CHRM2(5), CHRM3(7), CHRM4(2), CHRM5(2), CSK(1), CYFIP1(3), CYFIP2(5), DIAPH1(5), DIAPH2(2), DIAPH3(4), DOCK1(7), EGF(6), EGFR(6), EZR(1), F2(2), F2R(1), FGD1(1), FGD3(5), FGF12(1), FGF14(1), FGF20(3), FGF21(1), FGF23(1), FGF3(1), FGF5(2), FGF6(1), FGF7(1), FGF8(1), FGF9(1), FGFR1(2), FGFR2(4), FGFR3(3), FGFR4(6), FN1(13), GIT1(2), GNA12(1), GNA13(1), GNG12(1), GSN(2), INS(1), IQGAP1(8), IQGAP2(5), IQGAP3(7), ITGA1(5), ITGA10(7), ITGA11(6), ITGA2(4), ITGA2B(3), ITGA3(5), ITGA4(5), ITGA5(4), ITGA6(3), ITGA7(6), ITGA8(1), ITGA9(5), ITGAD(10), ITGAE(2), ITGAL(5), ITGAM(6), ITGAV(3), ITGAX(2), ITGB2(8), ITGB3(5), ITGB4(9), ITGB5(7), ITGB6(4), ITGB7(1), ITGB8(5), LIMK1(4), LIMK2(1), MAP2K2(2), MAPK1(3), MOS(2), MSN(3), MYH10(4), MYH14(12), MYH9(3), MYLK(3), MYLK2(2), NCKAP1(3), NCKAP1L(4), NRAS(3), PAK1(3), PAK2(3), PAK3(3), PAK4(2), PAK6(2), PAK7(10), PDGFA(2), PDGFB(1), PDGFRA(5), PDGFRB(1), PFN3(1), PFN4(1), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIK3R1(4), PIK3R2(4), PIK3R3(2), PIK3R5(1), PIP4K2A(1), PIP4K2B(3), PIP4K2C(1), PIP5K1B(1), PPP1CA(2), PPP1CC(1), PPP1R12A(2), PPP1R12B(4), PTK2(9), PXN(2), RAC3(1), RAF1(2), RDX(1), ROCK1(6), ROCK2(3), SCIN(5), SLC9A1(6), SOS1(8), SOS2(4), SSH1(1), SSH2(3), SSH3(2), TIAM1(5), TIAM2(6), VAV1(3), VAV3(8), VCL(3), WASF1(1), WASF2(2), WASL(2) 158834879 539 225 531 153 46 134 51 189 117 2 0.325 1.000 1.000 459 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 86 AGRN(3), CD36(3), CD44(4), CD47(2), COL11A1(21), COL11A2(10), COL1A1(6), COL1A2(8), COL2A1(9), COL3A1(8), COL4A1(8), COL4A2(6), COL4A4(9), COL4A6(6), COL5A1(14), COL5A2(5), COL5A3(9), COL6A1(6), COL6A2(4), COL6A3(18), COL6A6(16), DAG1(1), FN1(13), FNDC1(7), FNDC3A(3), FNDC5(1), GP1BB(1), GP6(3), HMMR(4), HSPG2(19), IBSP(2), ITGA1(5), ITGA10(7), ITGA11(6), ITGA2(4), ITGA2B(3), ITGA3(5), ITGA4(5), ITGA5(4), ITGA6(3), ITGA7(6), ITGA8(1), ITGA9(5), ITGAV(3), ITGB3(5), ITGB4(9), ITGB5(7), ITGB6(4), ITGB7(1), ITGB8(5), LAMA1(17), LAMA2(13), LAMA3(14), LAMA4(3), LAMA5(13), LAMB1(5), LAMB2(8), LAMB3(6), LAMB4(7), LAMC1(6), LAMC2(6), LAMC3(3), RELN(12), SDC2(1), SDC3(1), SDC4(2), SV2A(1), SV2B(3), SV2C(1), THBS1(6), THBS2(5), THBS3(6), THBS4(2), TNC(7), TNN(8), TNR(11), TNXB(12), VTN(1), VWF(7) 130554141 504 220 500 143 39 111 50 172 124 8 0.180 1.000 1.000 460 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 135 ADCY1(5), ADCY3(2), ADCY4(4), ADCY5(4), ADCY6(4), ADCY7(1), ADCY8(9), ADCY9(6), ADRA1B(1), ADRA1D(4), ADRB2(3), ADRB3(1), ANXA6(1), ARRB1(2), ARRB2(1), ATP1A4(6), ATP1B3(1), ATP2A2(7), ATP2A3(2), ATP2B1(5), ATP2B2(10), ATP2B3(4), CACNA1A(9), CACNA1B(13), CACNA1C(9), CACNA1D(6), CACNA1E(33), CACNA1S(6), CACNB1(2), CAMK1(1), CAMK2A(6), CAMK2B(2), CAMK2G(3), CASQ1(1), CASQ2(1), CHRM1(3), CHRM2(5), CHRM3(7), CHRM4(2), CHRM5(2), GJA1(1), GJA4(1), GJA5(3), GJB2(1), GJB4(2), GJB5(1), GJB6(2), GNAI2(1), GNAI3(1), GNAQ(1), GNAZ(2), GNB1(2), GNB2(3), GNB4(1), GNB5(4), GNG12(1), GNG4(1), ITPR1(15), ITPR2(11), ITPR3(11), KCNB1(2), KCNJ3(3), MIB1(4), NME7(1), PLCB3(4), PRKACA(2), PRKACB(2), PRKAR1B(1), PRKAR2B(3), PRKCA(1), PRKCG(4), PRKCH(5), PRKCQ(3), PRKCZ(4), PRKD1(5), RGS1(1), RGS10(1), RGS11(1), RGS14(1), RGS16(1), RGS18(4), RGS2(1), RGS20(1), RGS3(3), RGS4(2), RGS5(1), RGS6(2), RGS7(7), RGS9(1), RYR1(31), RYR2(42), RYR3(21), SLC8A1(6), SLC8A3(1), USP5(4) 107577428 435 213 426 106 46 88 40 178 82 1 0.0403 1.000 1.000 461 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 125 ABL1(2), ABLIM1(3), ABLIM2(1), ABLIM3(1), ARHGEF12(8), CDC42(3), CFL1(1), CFL2(2), CXCL12(1), CXCR4(2), DCC(10), DPYSL2(2), DPYSL5(5), EFNA3(1), EFNA4(1), EFNA5(2), EPHA1(5), EPHA2(5), EPHA3(14), EPHA4(13), EPHA5(6), EPHA6(7), EPHA7(7), EPHA8(7), EPHB1(5), EPHB2(4), EPHB3(8), EPHB4(1), EPHB6(3), FES(1), FYN(1), GNAI1(4), GNAI2(1), GNAI3(1), GSK3B(3), L1CAM(7), LIMK1(4), LIMK2(1), LRRC4C(4), MAPK1(3), MET(2), NCK1(1), NCK2(2), NFAT5(6), NFATC1(2), NFATC2(7), NFATC3(4), NFATC4(5), NGEF(1), NRAS(3), NRP1(2), NTN1(2), NTN4(2), NTNG1(1), PAK1(3), PAK2(3), PAK3(3), PAK4(2), PAK6(2), PAK7(10), PLXNA1(4), PLXNA2(7), PLXNA3(4), PLXNB1(4), PLXNB2(5), PLXNB3(8), PLXNC1(8), PPP3CA(3), PPP3CB(3), PTK2(9), RAC3(1), RASA1(10), RGS3(3), RND1(1), ROBO1(13), ROBO2(15), ROBO3(2), ROCK1(6), ROCK2(3), SEMA3A(10), SEMA3C(7), SEMA3D(7), SEMA3E(8), SEMA3F(2), SEMA3G(1), SEMA4A(1), SEMA4C(1), SEMA4D(3), SEMA4F(4), SEMA4G(1), SEMA5A(2), SEMA5B(7), SEMA6A(5), SEMA6B(2), SEMA6C(6), SEMA6D(13), SEMA7A(6), SLIT1(6), SLIT2(9), SLIT3(8), SRGAP1(3), SRGAP3(7), UNC5A(1), UNC5B(2), UNC5C(2), UNC5D(6) 112856095 462 209 454 137 43 98 49 178 92 2 0.516 1.000 1.000 462 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 136 ACTA1(1), ACTA2(1), ADCY1(5), ADCY3(2), ADCY4(4), ADCY5(4), ADCY6(4), ADCY7(1), ADCY8(9), ADCY9(6), ARRB1(2), ARRB2(1), ATF2(1), ATF3(3), ATF4(4), ATF5(1), ATP2A2(7), ATP2A3(2), CAMK2A(6), CAMK2B(2), CAMK2G(3), CNN1(1), CNN2(1), CORIN(5), CRH(1), CRHR1(5), DGKZ(2), ETS2(1), FOS(1), GABPB2(1), GBA2(1), GJA1(1), GNAQ(1), GNB1(2), GNB2(3), GNB4(1), GNB5(4), GNG12(1), GNG4(1), GSTO1(1), GUCA2B(1), GUCY1A3(4), IGFBP3(2), IGFBP4(1), IL1B(1), IL6(2), ITPR1(15), ITPR2(11), ITPR3(11), JUN(2), MIB1(4), MYLK2(2), NFKB1(3), NOS1(14), NOS3(9), OXTR(1), PDE4B(3), PDE4D(4), PLCB3(4), PLCD1(2), PLCG1(7), PLCG2(7), PRKACA(2), PRKACB(2), PRKAR1B(1), PRKAR2B(3), PRKCA(1), PRKCH(5), PRKCQ(3), PRKCZ(4), PRKD1(5), RGS1(1), RGS10(1), RGS11(1), RGS14(1), RGS16(1), RGS18(4), RGS2(1), RGS20(1), RGS3(3), RGS4(2), RGS5(1), RGS6(2), RGS7(7), RGS9(1), RLN1(2), RYR1(31), RYR2(42), RYR3(21), SLC8A1(6), SP1(2), TNXB(12), USP5(4) 99517436 386 191 377 91 32 72 39 153 88 2 0.0761 1.000 1.000 463 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 127 ACTG1(1), ACTN1(4), ACTN2(6), ACTN4(2), AKT1(2), AKT2(3), AKT3(2), AMOTL1(3), ASH1L(11), CASK(2), CDC42(3), CGN(3), CLDN1(1), CLDN16(3), CLDN17(1), CLDN18(1), CLDN2(1), CLDN20(3), CLDN4(1), CLDN5(1), CLDN8(2), CLDN9(2), CRB3(1), CSNK2A1(2), CTNNA1(3), CTNNA2(10), CTNNA3(5), CTTN(3), EPB41(1), EPB41L1(3), EPB41L2(2), EPB41L3(11), EXOC3(2), EXOC4(4), F11R(1), GNAI1(4), GNAI2(1), GNAI3(1), HCLS1(2), IGSF5(4), INADL(15), JAM2(3), JAM3(5), LLGL1(1), LLGL2(2), MAGI1(1), MAGI2(6), MAGI3(4), MLLT4(3), MPDZ(8), MPP5(1), MYH1(8), MYH10(4), MYH11(5), MYH13(5), MYH14(12), MYH15(14), MYH2(7), MYH3(6), MYH4(11), MYH6(9), MYH7(13), MYH7B(5), MYH8(5), MYH9(3), NRAS(3), OCLN(3), PARD3(3), PPP2CA(2), PPP2CB(1), PPP2R1A(3), PPP2R1B(3), PPP2R2A(2), PPP2R2C(2), PPP2R3A(3), PPP2R3B(2), PPP2R4(5), PRKCA(1), PRKCG(4), PRKCH(5), PRKCQ(3), PRKCZ(4), SPTAN1(7), SRC(3), SYMPK(4), TJAP1(2), TJP1(6), TJP2(2), TJP3(1), VAPA(1), YES1(2), ZAK(3) 108095336 354 183 349 108 21 82 37 134 78 2 0.749 1.000 1.000 464 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 142 APC(12), APC2(3), AXIN2(6), BTRC(5), CAMK2A(6), CAMK2B(2), CAMK2G(3), CCND1(1), CCND2(3), CER1(1), CHD8(2), CREBBP(6), CSNK1A1(2), CSNK1A1L(3), CSNK1E(3), CSNK2A1(2), CTBP1(1), CUL1(2), CXXC4(1), DAAM1(7), DAAM2(6), DKK1(1), DKK2(4), DVL1(3), DVL2(6), DVL3(1), EP300(11), FBXW11(1), FZD1(2), FZD10(1), FZD2(4), FZD3(2), FZD4(2), FZD6(2), FZD7(3), FZD8(2), FZD9(3), GSK3B(3), JUN(2), LEF1(2), LRP5(2), LRP6(2), MAP3K7(3), MAPK10(3), MAPK8(1), MAPK9(3), MMP7(3), MYC(2), NFAT5(6), NFATC1(2), NFATC2(7), NFATC3(4), NFATC4(5), NKD1(2), NKD2(3), NLK(2), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(9), PPP2CA(2), PPP2CB(1), PPP2R1A(3), PPP2R1B(3), PPP2R2A(2), PPP2R2C(2), PPP3CA(3), PPP3CB(3), PRICKLE1(5), PRICKLE2(6), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(1), PRKCG(4), PRKX(3), PSEN1(2), RAC3(1), ROCK1(6), ROCK2(3), SENP2(3), SFRP2(2), SFRP5(3), SIAH1(4), SMAD2(1), SMAD3(3), SMAD4(5), TBL1X(1), TBL1XR1(4), TBL1Y(2), TCF7(2), TCF7L1(3), TCF7L2(3), VANGL1(3), VANGL2(1), WIF1(6), WNT1(2), WNT11(1), WNT2(3), WNT3A(2), WNT4(1), WNT5B(1), WNT6(1), WNT7A(2), WNT7B(1), WNT8A(2), WNT8B(1), WNT9A(2), WNT9B(2) 90314269 329 179 322 77 27 71 28 121 80 2 0.0667 1.000 1.000 465 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 250 ACVR1(2), ACVR1B(2), ACVR2B(3), AMH(1), AMHR2(2), BMP2(2), BMP7(3), BMPR1A(1), BMPR1B(2), BMPR2(5), CCL11(1), CCL13(1), CCL14(1), CCL15(1), CCL16(1), CCL18(1), CCL24(1), CCL25(1), CCL3(1), CCL8(1), CCR1(1), CCR2(1), CCR3(3), CCR4(1), CCR5(2), CCR6(5), CCR7(2), CCR8(1), CCR9(1), CD40(3), CD70(2), CLCF1(2), CNTFR(2), CRLF2(1), CSF1(2), CSF1R(1), CSF2RB(2), CSF3R(1), CX3CL1(2), CXCL1(1), CXCL12(1), CXCL13(1), CXCL14(2), CXCL5(1), CXCR3(3), CXCR4(2), EDA(2), EDA2R(2), EDAR(1), EGF(6), EGFR(6), EPOR(1), FAS(3), FLT1(4), FLT3(4), FLT3LG(2), FLT4(6), GDF5(2), GH1(1), GH2(3), GHR(3), HGF(7), IFNA13(1), IFNA14(3), IFNA16(1), IFNA17(1), IFNA2(2), IFNA4(1), IFNA5(2), IFNA6(2), IFNA7(1), IFNA8(4), IFNAR1(2), IFNAR2(1), IFNB1(2), IFNG(3), IFNGR1(3), IFNGR2(1), IFNW1(1), IL10(1), IL10RA(3), IL10RB(2), IL11RA(1), IL12A(6), IL12B(2), IL12RB1(3), IL12RB2(5), IL13RA1(2), IL17A(1), IL17RA(2), IL17RB(1), IL18(2), IL18R1(2), IL18RAP(6), IL1B(1), IL1R1(4), IL1R2(1), IL1RAP(1), IL20RA(3), IL21R(8), IL22(1), IL22RA1(1), IL23A(1), IL23R(4), IL24(1), IL2RA(1), IL2RB(2), IL2RG(1), IL4(1), IL4R(1), IL5(1), IL5RA(1), IL6(2), IL6R(3), IL7(1), IL7R(1), IL9R(2), INHBA(3), INHBC(1), INHBE(2), KDR(7), KIT(12), KITLG(2), LEP(2), LEPR(4), LIF(1), LIFR(5), LTBR(1), MET(2), MPL(1), NGFR(3), OSMR(1), PDGFB(1), PDGFC(3), PDGFRA(5), PDGFRB(1), PF4(1), PF4V1(1), PPBP(1), PRL(3), PRLR(1), TGFB1(1), TGFB2(4), TGFB3(2), TGFBR1(1), TGFBR2(1), TNF(1), TNFRSF10B(2), TNFRSF10D(2), TNFRSF11A(1), TNFRSF11B(4), TNFRSF14(1), TNFRSF18(1), TNFRSF1A(1), TNFRSF1B(1), TNFRSF21(4), TNFRSF25(2), TNFRSF4(2), TNFRSF6B(1), TNFRSF8(3), TNFSF10(1), TNFSF11(1), TNFSF13B(1), TNFSF14(1), TNFSF15(1), TNFSF18(1), TNFSF4(1), TNFSF8(1), TPO(13), TSLP(1), VEGFA(1), VEGFC(6), XCL1(1), XCL2(1), XCR1(1) 99705607 376 175 370 121 18 85 38 154 80 1 0.793 1.000 1.000 466 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 129 ACACA(10), ACACB(10), AKT1(2), AKT2(3), AKT3(2), ARAF(5), CALML6(2), CBL(4), CBLB(3), CBLC(1), EXOC7(6), FASN(18), FBP1(1), FBP2(2), FLOT1(3), FOXO1(1), G6PC(3), GSK3B(3), GYS1(3), GYS2(5), IKBKB(4), INS(1), INSR(4), IRS1(3), IRS2(2), IRS4(7), LIPE(1), MAP2K2(2), MAPK1(3), MAPK10(3), MAPK8(1), MAPK9(3), MKNK1(2), MKNK2(3), NRAS(3), PCK1(6), PCK2(1), PDE3A(8), PDE3B(2), PDPK1(1), PFKL(1), PFKM(1), PFKP(2), PHKA1(6), PHKA2(3), PHKB(8), PHKG2(2), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIK3R1(4), PIK3R2(4), PIK3R3(2), PIK3R5(1), PKLR(3), PPARGC1A(6), PPP1CA(2), PPP1CC(1), PPP1R3A(6), PPP1R3C(1), PRKAA1(4), PRKAB2(1), PRKACA(2), PRKACB(2), PRKACG(2), PRKAG2(3), PRKAG3(2), PRKAR1B(1), PRKAR2B(3), PRKCZ(4), PRKX(3), PYGB(2), PYGL(2), PYGM(8), RAF1(2), RAPGEF1(8), RHEB(1), RPS6(2), RPS6KB1(2), RPS6KB2(4), SHC1(3), SHC4(4), SLC2A4(2), SOCS2(1), SOCS3(1), SORBS1(1), SOS1(8), SOS2(4), SREBF1(3), TRIP10(3), TSC1(8), TSC2(12) 91375070 321 166 316 77 26 85 35 94 78 3 0.0311 1.000 1.000 467 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 128 ALCAM(1), CADM1(4), CADM3(2), CD22(5), CD226(1), CD276(1), CD4(1), CD40(3), CD58(1), CD6(3), CD80(4), CD86(2), CD8A(1), CD8B(1), CDH1(7), CDH15(6), CDH2(1), CDH3(1), CDH4(3), CDH5(2), CLDN1(1), CLDN16(3), CLDN17(1), CLDN18(1), CLDN2(1), CLDN20(3), CLDN4(1), CLDN5(1), CLDN8(2), CLDN9(2), CNTN1(7), CNTN2(6), CNTNAP2(8), CTLA4(1), ESAM(2), F11R(1), GLG1(6), HLA-A(3), HLA-B(3), HLA-C(2), HLA-DMA(2), HLA-DMB(1), HLA-DOB(1), HLA-DQA1(1), HLA-DQA2(1), HLA-DQB1(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(1), HLA-E(3), HLA-G(3), ICAM1(1), ICAM3(1), ITGA4(5), ITGA6(3), ITGA8(1), ITGA9(5), ITGAL(5), ITGAM(6), ITGAV(3), ITGB2(8), ITGB7(1), ITGB8(5), JAM2(3), JAM3(5), L1CAM(7), MADCAM1(1), MAG(2), MPZ(1), NCAM1(5), NCAM2(4), NEGR1(2), NEO1(4), NFASC(10), NLGN2(2), NLGN3(2), NRCAM(8), NRXN1(8), NRXN2(4), NRXN3(6), OCLN(3), PDCD1(1), PDCD1LG2(1), PTPRC(8), PTPRM(11), PVR(3), PVRL1(2), PVRL2(2), PVRL3(2), SDC2(1), SDC3(1), SDC4(2), SELE(1), SELP(1), SELPLG(1), SIGLEC1(6), SPN(3), VCAM1(3), VCAN(12) 82911256 303 165 299 89 19 75 35 109 65 0 0.518 1.000 1.000 468 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 149 AKT1(2), AKT2(3), AKT3(2), CBL(4), CBLB(3), CBLC(1), CCND1(1), CCND2(3), CISH(5), CLCF1(2), CNTFR(2), CREBBP(6), CRLF2(1), CSF2RB(2), CSF3R(1), EP300(11), EPOR(1), GH1(1), GH2(3), GHR(3), IFNA13(1), IFNA14(3), IFNA16(1), IFNA17(1), IFNA2(2), IFNA4(1), IFNA5(2), IFNA6(2), IFNA7(1), IFNA8(4), IFNAR1(2), IFNAR2(1), IFNB1(2), IFNG(3), IFNGR1(3), IFNGR2(1), IFNW1(1), IL10(1), IL10RA(3), IL10RB(2), IL11RA(1), IL12A(6), IL12B(2), IL12RB1(3), IL12RB2(5), IL13RA1(2), IL13RA2(2), IL20RA(3), IL21R(8), IL22(1), IL22RA1(1), IL23A(1), IL23R(4), IL24(1), IL2RA(1), IL2RB(2), IL2RG(1), IL4(1), IL4R(1), IL5(1), IL5RA(1), IL6(2), IL6R(3), IL7(1), IL7R(1), IL9R(2), IRF9(2), JAK2(4), JAK3(7), LEP(2), LEPR(4), LIF(1), LIFR(5), MPL(1), MYC(2), OSMR(1), PIAS2(2), PIAS3(1), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIK3R1(4), PIK3R2(4), PIK3R3(2), PIK3R5(1), PIM1(1), PRL(3), PRLR(1), PTPN11(4), PTPN6(2), SOCS2(1), SOCS3(1), SOCS5(2), SOCS7(1), SOS1(8), SOS2(4), SPRED1(1), SPRY1(3), SPRY2(3), SPRY3(1), SPRY4(1), STAM(2), STAT1(5), STAT3(4), STAT4(4), STAT5A(2), STAT5B(1), STAT6(5), TPO(13), TSLP(1), TYK2(1) 79006156 282 156 275 80 18 66 31 108 58 1 0.419 1.000 1.000 469 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 90 ADCY1(5), ADCY3(2), ADCY4(4), ADCY5(4), ADCY6(4), ADCY7(1), ADCY8(9), ADCY9(6), DRD1(1), DRD2(4), EGF(6), EGFR(6), GJA1(1), GJD2(2), GNAI1(4), GNAI2(1), GNAI3(1), GNAQ(1), GNAS(10), GRM1(4), GRM5(5), GUCY1A2(3), GUCY1A3(4), GUCY1B3(3), GUCY2C(6), GUCY2D(3), GUCY2F(2), HTR2C(3), ITPR1(15), ITPR2(11), ITPR3(11), MAP2K2(2), MAP2K5(1), MAP3K2(5), MAPK1(3), MAPK7(3), NPR1(2), NPR2(3), NRAS(3), PDGFA(2), PDGFB(1), PDGFC(3), PDGFD(3), PDGFRA(5), PDGFRB(1), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(9), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(1), PRKCG(4), PRKG1(6), PRKG2(4), PRKX(3), RAF1(2), SOS1(8), SOS2(4), SRC(3), TJP1(6), TUBA1A(1), TUBA3C(2), TUBA3D(2), TUBA3E(4), TUBA4A(3), TUBA8(2), TUBAL3(1), TUBB(1), TUBB1(2), TUBB2A(1), TUBB2B(1), TUBB3(1), TUBB6(2), TUBB8(2) 74556289 275 153 269 70 24 67 25 101 56 2 0.155 1.000 1.000 470 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 93 ADCY1(5), ADCY3(2), ADCY4(4), ADCY5(4), ADCY6(4), ADCY7(1), ADCY8(9), ADCY9(6), ATF4(4), CACNA1C(9), CACNA1D(6), CACNA1F(3), CACNA1S(6), CALML6(2), CAMK2A(6), CAMK2B(2), CAMK2G(3), CDC42(3), CGA(1), EGFR(6), GNAQ(1), GNAS(10), GNRH1(2), GNRH2(1), ITPR1(15), ITPR2(11), ITPR3(11), JUN(2), LHB(2), MAP2K2(2), MAP2K3(2), MAP2K4(4), MAP2K6(2), MAP2K7(2), MAP3K1(3), MAP3K2(5), MAP3K3(1), MAP3K4(9), MAPK1(3), MAPK10(3), MAPK11(1), MAPK12(1), MAPK14(3), MAPK7(3), MAPK8(1), MAPK9(3), MMP14(3), MMP2(1), NRAS(3), PLA2G12B(1), PLA2G2D(1), PLA2G2F(5), PLA2G3(7), PLA2G4A(8), PLA2G6(3), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(9), PLD1(4), PLD2(3), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(1), PRKX(3), PTK2B(5), RAF1(2), SOS1(8), SOS2(4), SRC(3) 73068534 284 153 276 56 27 62 29 92 71 3 0.00191 1.000 1.000 471 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(2), AKT3(2), BCAR1(3), CAPN1(2), CAPN10(1), CAPN11(8), CAPN2(1), CAPN3(3), CAPN6(4), CAPN7(2), CAPN9(3), CAPNS1(1), CAV1(1), CAV2(1), CDC42(3), CSK(1), DOCK1(7), FYN(1), GIT2(2), ITGA10(7), ITGA11(6), ITGA2(4), ITGA2B(3), ITGA3(5), ITGA4(5), ITGA5(4), ITGA6(3), ITGA7(6), ITGA8(1), ITGA9(5), ITGAD(10), ITGAE(2), ITGAL(5), ITGAM(6), ITGAV(3), ITGAX(2), ITGB2(8), ITGB3(5), ITGB4(9), ITGB5(7), ITGB6(4), ITGB7(1), ITGB8(5), MAP2K2(2), MAP2K3(2), MAP2K6(2), MAPK10(3), MAPK12(1), MAPK4(5), MAPK6(3), MAPK7(3), MYLK2(2), PAK1(3), PAK2(3), PAK3(3), PAK4(2), PAK6(2), PDPK1(1), PIK3R2(4), PTK2(9), PXN(2), RAC3(1), RAPGEF1(8), RHO(3), ROCK1(6), ROCK2(3), SDCCAG8(6), SHC1(3), SORBS1(1), SOS1(8), SRC(3), TLN1(10), TNS1(10), VASP(2), VAV3(8), VCL(3), ZYX(2) 78104132 293 153 291 66 24 75 22 97 74 1 0.0516 1.000 1.000 472 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(1), ACTA2(1), ACTN2(6), ACTN4(2), DES(3), DMD(19), MYBPC1(1), MYBPC2(3), MYBPC3(2), MYH3(6), MYH6(9), MYH7(13), MYH8(5), MYOM1(13), NEB(17), TCAP(1), TMOD1(1), TNNC2(2), TNNI2(1), TNNT3(1), TPM2(3), TPM3(1), TPM4(1), TTN(133), VIM(4) 79225948 249 152 247 76 14 52 35 102 43 3 0.621 1.000 1.000 473 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 161 ADORA1(1), ADORA2A(2), ADORA2B(1), ADORA3(2), ADRA1B(1), ADRA1D(4), ADRA2C(1), ADRB2(3), ADRB3(1), AGTR1(2), AVPR1A(3), AVPR1B(2), AVPR2(1), BDKRB2(3), C3AR1(1), CCKAR(1), CCKBR(3), CCR1(1), CCR2(1), CCR3(3), CCR4(1), CCR5(2), CCR6(5), CCR7(2), CCR8(1), CCR9(1), CHML(2), CHRM1(3), CHRM2(5), CHRM3(7), CHRM4(2), CHRM5(2), CMKLR1(2), CNR1(3), CNR2(1), CXCR3(3), CXCR4(2), DRD1(1), DRD2(4), DRD3(2), DRD5(1), EDNRA(1), EDNRB(2), F2R(1), F2RL3(1), FPR1(1), FSHR(4), GALR2(1), GHSR(2), GNB2L1(1), GPR17(1), GPR173(2), GPR174(4), GPR3(3), GPR35(2), GPR37(3), GPR37L1(1), GPR4(2), GPR50(2), GPR63(7), GPR83(4), GPR85(2), GPR87(1), GRPR(1), HCRTR1(1), HCRTR2(2), HRH1(2), HRH3(2), HTR1A(2), HTR1B(1), HTR1D(1), HTR1E(3), HTR1F(1), HTR2C(3), HTR5A(2), HTR6(1), HTR7(5), LHCGR(6), LTB4R(1), MC3R(2), MC4R(2), MC5R(1), MTNR1A(2), MTNR1B(3), NMBR(1), NMUR1(3), NMUR2(6), NPY1R(3), NPY2R(4), NPY5R(5), NTSR2(3), OPN3(1), OPRK1(3), OPRL1(2), OPRM1(4), OR10A5(2), OR11A1(3), OR12D3(3), OR1C1(2), OR1Q1(1), OR2H1(1), OR5V1(3), OR7A5(3), OR8B8(3), OXTR(1), P2RY1(4), P2RY10(3), P2RY12(3), P2RY13(1), P2RY14(1), P2RY2(1), P2RY6(1), PTGER1(1), PTGER2(3), PTGER4(1), PTGFR(2), PTGIR(2), RGR(1), RHO(3), RRH(2), SSTR2(1), SSTR4(3), SUCNR1(2), TRHR(3) 67504399 276 151 267 86 32 52 26 134 32 0 0.328 1.000 1.000 474 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 73 ARAF(5), CACNA1A(9), CRH(1), CRHR1(5), GNA12(1), GNA13(1), GNAI1(4), GNAI2(1), GNAI3(1), GNAQ(1), GNAS(10), GNAZ(2), GRIA1(10), GRIA2(9), GRIA3(6), GRID2(4), GRM1(4), GRM5(5), GUCY1A2(3), GUCY1A3(4), GUCY1B3(3), GUCY2C(6), GUCY2D(3), GUCY2F(2), IGF1R(11), ITPR1(15), ITPR2(11), ITPR3(11), LYN(1), MAP2K2(2), MAPK1(3), NOS1(14), NOS3(9), NPR1(2), NPR2(3), NRAS(3), PLA2G12B(1), PLA2G2D(1), PLA2G2F(5), PLA2G3(7), PLA2G4A(8), PLA2G6(3), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(9), PPP2CA(2), PPP2CB(1), PPP2R1A(3), PPP2R1B(3), PPP2R2A(2), PPP2R2C(2), PRKCA(1), PRKCG(4), PRKG1(6), PRKG2(4), RAF1(2), RYR1(31) 63976041 295 151 284 58 33 57 30 118 57 0 0.00164 1.000 1.000 475 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 124 ARAF(5), CASP3(3), CD244(2), CD247(1), FAS(3), FYN(1), GZMB(2), HLA-A(3), HLA-B(3), HLA-C(2), HLA-E(3), HLA-G(3), ICAM1(1), IFNA13(1), IFNA14(3), IFNA16(1), IFNA17(1), IFNA2(2), IFNA4(1), IFNA5(2), IFNA6(2), IFNA7(1), IFNA8(4), IFNAR1(2), IFNAR2(1), IFNB1(2), IFNG(3), IFNGR1(3), IFNGR2(1), ITGAL(5), ITGB2(8), KIR2DL3(3), KLRC1(1), KLRC3(2), KLRK1(5), LAT(1), LCK(4), LCP2(5), MAP2K2(2), MAPK1(3), MICA(2), NCR1(2), NCR2(1), NCR3(1), NFAT5(6), NFATC1(2), NFATC2(7), NFATC3(4), NFATC4(5), NRAS(3), PAK1(3), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIK3R1(4), PIK3R2(4), PIK3R3(2), PIK3R5(1), PLCG1(7), PLCG2(7), PPP3CA(3), PPP3CB(3), PRF1(4), PRKCA(1), PRKCG(4), PTK2B(5), PTPN11(4), PTPN6(2), RAC3(1), RAF1(2), SH2D1A(1), SH3BP2(2), SHC1(3), SHC4(4), SOS1(8), SOS2(4), SYK(1), TNF(1), TNFRSF10B(2), TNFRSF10D(2), TNFSF10(1), VAV1(3), VAV3(8), ZAP70(3) 63043953 247 146 239 51 17 62 22 91 54 1 0.0194 1.000 1.000 476 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 108 ACTN1(4), ACTN2(6), ACTN4(2), ARHGAP5(3), BCAR1(3), CDC42(3), CDH5(2), CLDN1(1), CLDN16(3), CLDN17(1), CLDN18(1), CLDN2(1), CLDN20(3), CLDN4(1), CLDN5(1), CLDN8(2), CLDN9(2), CTNNA1(3), CTNNA2(10), CTNNA3(5), CTNND1(3), CXCL12(1), CXCR4(2), CYBA(2), CYBB(2), ESAM(2), EZR(1), F11R(1), GNAI1(4), GNAI2(1), GNAI3(1), ICAM1(1), ITGA4(5), ITGAL(5), ITGAM(6), ITGB2(8), ITK(1), JAM2(3), JAM3(5), MAPK11(1), MAPK12(1), MAPK14(3), MLLT4(3), MMP2(1), MMP9(3), MSN(3), NCF1(1), NCF2(1), NCF4(2), NOX1(3), NOX3(5), OCLN(3), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIK3R1(4), PIK3R2(4), PIK3R3(2), PIK3R5(1), PLCG1(7), PLCG2(7), PRKCA(1), PRKCG(4), PTK2(9), PTK2B(5), PTPN11(4), PXN(2), RAP1A(2), RAPGEF3(2), RAPGEF4(2), RHOH(1), ROCK1(6), ROCK2(3), SIPA1(2), THY1(1), TXK(2), VASP(2), VAV1(3), VAV3(8), VCAM1(3), VCL(3) 69442385 244 145 240 46 16 65 28 78 57 0 0.00481 1.000 1.000 477 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(8), ABCA10(6), ABCA12(20), ABCA13(36), ABCA2(8), ABCA3(6), ABCA4(15), ABCA5(4), ABCA6(4), ABCA7(6), ABCA8(2), ABCA9(7), ABCB1(8), ABCB10(2), ABCB11(2), ABCB4(5), ABCB5(12), ABCB6(3), ABCB7(3), ABCB8(2), ABCB9(1), ABCC1(3), ABCC10(6), ABCC11(3), ABCC12(3), ABCC2(4), ABCC3(5), ABCC4(4), ABCC5(5), ABCC6(7), ABCC8(7), ABCC9(6), ABCD1(2), ABCD2(3), ABCD3(1), ABCG1(1), ABCG2(2), ABCG4(6), ABCG5(6), ABCG8(1), CFTR(3), TAP1(2) 68015304 240 143 235 56 16 58 23 92 50 1 0.0363 1.000 1.000 478 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 96 ADCY1(5), ADCY3(2), ADCY4(4), ADCY5(4), ADCY6(4), ADCY7(1), ADCY8(9), ADCY9(6), CALML6(2), CAMK2A(6), CAMK2B(2), CAMK2G(3), CREB1(1), CREB3L1(2), CREB3L2(2), CREB3L3(5), CREB3L4(3), CREBBP(6), DCT(3), DVL1(3), DVL2(6), DVL3(1), EDN1(2), EDNRB(2), EP300(11), FZD1(2), FZD10(1), FZD2(4), FZD3(2), FZD4(2), FZD6(2), FZD7(3), FZD8(2), FZD9(3), GNAI1(4), GNAI2(1), GNAI3(1), GNAQ(1), GNAS(10), GSK3B(3), KIT(12), KITLG(2), LEF1(2), MAP2K2(2), MAPK1(3), MITF(1), NRAS(3), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(9), POMC(2), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(1), PRKCG(4), PRKX(3), RAF1(2), TCF7(2), TCF7L1(3), TCF7L2(3), TYR(5), WNT1(2), WNT11(1), WNT2(3), WNT3A(2), WNT4(1), WNT5B(1), WNT6(1), WNT7A(2), WNT7B(1), WNT8A(2), WNT8B(1), WNT9A(2), WNT9B(2) 60247229 237 138 228 66 18 62 16 77 63 1 0.428 1.000 1.000 479 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 141 ADA(1), ADCY1(5), ADCY3(2), ADCY4(4), ADCY5(4), ADCY6(4), ADCY7(1), ADCY8(9), ADCY9(6), ADK(1), ADSL(2), ADSS(2), AK1(1), AK2(1), AK5(1), AK7(5), ALLC(2), AMPD1(5), AMPD2(2), AMPD3(3), ATIC(2), ENPP1(1), ENPP3(4), ENTPD1(3), ENTPD2(1), ENTPD5(1), ENTPD6(3), GART(4), GDA(2), GMPR2(1), GMPS(4), GUCY1A2(3), GUCY1A3(4), GUCY1B3(3), GUCY2C(6), GUCY2D(3), GUCY2F(2), GUK1(1), IMPDH1(1), NME1(2), NME2(1), NME6(2), NME7(1), NPR1(2), NPR2(3), NT5C1B(3), NT5C2(1), NT5E(1), NT5M(2), NUDT5(1), PAICS(2), PAPSS1(2), PAPSS2(1), PDE10A(6), PDE11A(7), PDE1A(2), PDE1C(9), PDE2A(1), PDE3B(2), PDE4A(1), PDE4B(3), PDE4C(4), PDE4D(4), PDE5A(3), PDE7A(2), PDE7B(1), PDE8A(5), PDE8B(1), PDE9A(2), PFAS(3), PKLR(3), PNPT1(3), POLA1(4), POLD1(4), POLD4(1), POLE(4), POLE2(4), POLE3(1), POLR1A(7), POLR1B(2), POLR1C(1), POLR2A(7), POLR2B(6), POLR2G(2), POLR2H(1), POLR2I(2), POLR3A(3), POLR3B(2), POLR3H(1), PPAT(4), PRIM1(3), PRPS1(1), PRPS1L1(1), PRUNE(2), RFC5(2), RRM1(5), XDH(8), ZNRD1(1) 92449055 275 136 271 81 21 71 17 91 73 2 0.639 1.000 1.000 480 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 91 AKT1(2), AKT2(3), AKT3(2), BCL10(1), CARD11(11), CBL(4), CBLB(3), CBLC(1), CD247(1), CD3G(1), CD4(1), CD8A(1), CD8B(1), CDC42(3), CHUK(8), CTLA4(1), FOS(1), FYN(1), GRAP2(3), IFNG(3), IKBKB(4), IL10(1), IL4(1), IL5(1), ITK(1), JUN(2), LAT(1), LCK(4), LCP2(5), MALT1(3), MAP3K8(1), NCK1(1), NCK2(2), NFAT5(6), NFATC1(2), NFATC2(7), NFATC3(4), NFATC4(5), NFKB1(3), NFKB2(2), NFKBIA(2), NRAS(3), PAK1(3), PAK2(3), PAK3(3), PAK4(2), PAK6(2), PAK7(10), PDCD1(1), PDK1(1), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIK3R1(4), PIK3R2(4), PIK3R3(2), PIK3R5(1), PLCG1(7), PPP3CA(3), PPP3CB(3), PRKCQ(3), PTPN6(2), PTPRC(8), RASGRP1(5), SOS1(8), SOS2(4), TNF(1), VAV1(3), VAV3(8), ZAP70(3) 56570704 220 136 216 44 16 59 22 74 48 1 0.0157 1.000 1.000 481 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 75 ABL1(2), ACTN1(4), ACTR2(1), AKT1(2), AKT2(3), AKT3(2), ANGPTL2(1), ARHGEF6(3), ARHGEF7(4), BCAR1(3), CAV1(1), CDC42(3), CSE1L(1), DOCK1(7), EPHB2(4), FYN(1), GRB7(1), ITGA1(5), ITGA10(7), ITGA11(6), ITGA2(4), ITGA3(5), ITGA4(5), ITGA5(4), ITGA6(3), ITGA7(6), ITGA8(1), ITGA9(5), ITGB3BP(1), MAP2K4(4), MAP2K7(2), MAP3K11(1), MAPK1(3), MAPK10(3), MAPK8(1), MAPK8IP1(1), MAPK8IP3(2), MAPK9(3), MYLK(3), MYLK2(2), P4HB(1), PAK1(3), PAK2(3), PAK3(3), PAK4(2), PAK6(2), PAK7(10), PIK3CB(5), PKLR(3), PLCG1(7), PLCG2(7), PTK2(9), RAF1(2), RALA(2), RHO(3), ROCK1(6), ROCK2(3), SHC1(3), SOS1(8), SOS2(4), SRC(3), TERF2IP(1), TLN1(10), TLN2(9), VASP(2), ZYX(2) 68341472 233 136 231 54 19 52 22 76 63 1 0.0853 1.000 1.000 482 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 74 ACP1(2), ACTG1(1), ACTN1(4), ACTN2(6), ACTN4(2), ACVR1B(2), ACVR1C(1), BAIAP2(1), CDC42(3), CDH1(7), CREBBP(6), CSNK2A1(2), CTNNA1(3), CTNNA2(10), CTNNA3(5), CTNND1(3), EGFR(6), EP300(11), ERBB2(4), FARP2(4), FER(2), FGFR1(2), FYN(1), IGF1R(11), INSR(4), IQGAP1(8), LEF1(2), LMO7(7), MAP3K7(3), MAPK1(3), MET(2), MLLT4(3), NLK(2), PARD3(3), PTPN6(2), PTPRB(14), PTPRJ(4), PTPRM(11), PVRL1(2), PVRL2(2), PVRL3(2), RAC3(1), SMAD2(1), SMAD3(3), SMAD4(5), SNAI1(2), SORBS1(1), SRC(3), SSX2IP(3), TCF7(2), TCF7L1(3), TCF7L2(3), TGFBR1(1), TGFBR2(1), TJP1(6), VCL(3), WASF1(1), WASF2(2), WASF3(2), WASL(2), YES1(2) 67241346 220 134 216 60 12 51 35 71 51 0 0.206 1.000 1.000 483 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 65 ADCY1(5), ADCY8(9), ARAF(5), ATF4(4), CACNA1C(9), CALML6(2), CAMK2A(6), CAMK2B(2), CAMK2G(3), CREBBP(6), EP300(11), GNAQ(1), GRIA1(10), GRIA2(9), GRIN1(5), GRIN2A(6), GRIN2B(3), GRIN2C(5), GRIN2D(2), GRM1(4), GRM5(5), ITPR1(15), ITPR2(11), ITPR3(11), MAP2K2(2), MAPK1(3), NRAS(3), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(9), PPP1CA(2), PPP1CC(1), PPP1R12A(2), PPP3CA(3), PPP3CB(3), PRKACA(2), PRKACB(2), PRKACG(2), PRKCA(1), PRKCG(4), PRKX(3), RAF1(2), RAP1A(2), RAPGEF3(2), RPS6KA1(1), RPS6KA2(5), RPS6KA6(8) 57179661 226 134 221 60 19 55 23 80 48 1 0.200 1.000 1.000 484 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 71 CALML6(2), CDIPT(1), CDS1(2), DGKA(4), DGKB(1), DGKD(3), DGKE(3), DGKG(5), DGKH(3), DGKI(5), DGKQ(1), DGKZ(2), FN3K(1), IMPA1(2), IMPA2(2), INPP4A(1), INPP4B(6), INPP5A(3), INPP5B(1), INPP5E(2), INPPL1(1), ITPK1(2), ITPKA(1), ITPKB(4), ITPR1(15), ITPR2(11), ITPR3(11), OCRL(4), PI4KA(4), PI4KB(2), PIK3C2A(4), PIK3C2B(8), PIK3C2G(7), PIK3C3(2), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIK3R1(4), PIK3R2(4), PIK3R3(2), PIK3R5(1), PIP4K2A(1), PIP4K2B(3), PIP4K2C(1), PIP5K1B(1), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(9), PLCD1(2), PLCD3(1), PLCD4(3), PLCE1(5), PLCG1(7), PLCG2(7), PLCZ1(3), PRKCA(1), PRKCG(4), PTPMT1(1), SYNJ1(7), SYNJ2(3) 70791232 224 131 219 59 16 56 26 62 64 0 0.213 1.000 1.000 485 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 109 ADA(1), ADCY1(5), ADCY3(2), ADCY4(4), ADCY5(4), ADCY6(4), ADCY7(1), ADCY8(9), ADK(1), ADSL(2), ADSS(2), AK1(1), AK2(1), AK5(1), ALLC(2), AMPD1(5), AMPD2(2), AMPD3(3), ATIC(2), ATP5A1(4), ATP5B(4), ATP5C1(1), ATP5F1(1), ATP5G2(1), ENPP1(1), ENPP3(4), ENTPD1(3), ENTPD2(1), GART(4), GDA(2), GMPS(4), GUCY1A2(3), GUCY1A3(4), GUCY1B3(3), GUCY2C(6), GUCY2D(3), GUCY2F(2), GUK1(1), IMPDH1(1), NME1(2), NME2(1), NPR1(2), NPR2(3), NT5E(1), NT5M(2), PAICS(2), PAPSS1(2), PAPSS2(1), PDE1A(2), PDE4A(1), PDE4B(3), PDE4C(4), PDE4D(4), PDE5A(3), PDE6B(8), PDE7B(1), PDE8A(5), PDE9A(2), PFAS(3), PKLR(3), POLB(2), POLD1(4), POLE(4), POLG(5), POLL(1), POLQ(17), POLR1B(2), POLR2A(7), POLR2B(6), POLR2G(2), POLR2H(1), POLR2I(2), POLRMT(1), PPAT(4), PRPS1(1), PRPS1L1(1), PRUNE(2), RRM1(5) 72340603 227 131 224 68 17 66 19 79 46 0 0.541 1.000 1.000 486 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 89 ADCY1(5), ADCY3(2), ADCY4(4), ADCY5(4), ADCY6(4), ADCY7(1), ADCY8(9), ADCY9(6), AKAP1(3), AKAP10(1), AKAP11(9), AKAP12(3), AKAP2(4), AKAP3(4), AKAP4(2), AKAP5(1), AKAP6(10), AKAP7(1), AKAP8(3), AKAP9(8), ARHGEF1(1), CHMP1B(3), GNA12(1), GNA13(1), GNA15(1), GNAI2(1), GNAI3(1), GNAL(2), GNAQ(1), GNAZ(2), GNB1(2), GNB2(3), GNB5(4), GNG12(1), GNG4(1), ITPR1(15), KCNJ3(3), NRAS(3), PDE1A(2), PDE1B(2), PDE1C(9), PDE4A(1), PDE4B(3), PDE4C(4), PDE4D(4), PDE7A(2), PDE7B(1), PDE8A(5), PDE8B(1), PLCB3(4), PPP3CA(3), PRKACA(2), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), PRKCA(1), PRKCG(4), PRKCH(5), PRKCQ(3), PRKCZ(4), PRKD1(5), SLC9A1(6), USP5(4) 64601992 213 130 208 58 17 53 19 76 47 1 0.350 1.000 1.000 487 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 82 ABL1(2), ABL2(4), AKT1(2), AKT2(3), AKT3(2), ARAF(5), BTC(1), CAMK2A(6), CAMK2B(2), CAMK2G(3), CBL(4), CBLB(3), CBLC(1), CDKN1B(5), EGF(6), EGFR(6), ERBB2(4), ERBB3(8), ERBB4(11), GAB1(3), GSK3B(3), JUN(2), MAP2K2(2), MAP2K4(4), MAP2K7(2), MAPK1(3), MAPK10(3), MAPK8(1), MAPK9(3), MYC(2), NCK1(1), NCK2(2), NRAS(3), NRG1(2), NRG2(1), NRG3(3), NRG4(1), PAK1(3), PAK2(3), PAK3(3), PAK4(2), PAK6(2), PAK7(10), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIK3R1(4), PIK3R2(4), PIK3R3(2), PIK3R5(1), PLCG1(7), PLCG2(7), PRKCA(1), PRKCG(4), PTK2(9), RAF1(2), RPS6KB1(2), RPS6KB2(4), SHC1(3), SHC4(4), SOS1(8), SOS2(4), SRC(3), STAT5A(2), STAT5B(1), TGFA(1) 57472463 228 130 220 47 13 56 22 78 58 1 0.0252 1.000 1.000 488 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1(2), ACVR1B(2), ACVR1C(1), ACVR2B(3), ACVRL1(1), AMH(1), AMHR2(2), BMP2(2), BMP4(1), BMP5(4), BMP6(2), BMP7(3), BMPR1A(1), BMPR1B(2), BMPR2(5), CDKN2B(1), CHRD(2), COMP(5), CREBBP(6), CUL1(2), DCN(2), E2F4(2), EP300(11), FST(2), GDF5(2), ID1(2), IFNG(3), INHBA(3), INHBC(1), INHBE(2), LEFTY2(1), LTBP1(9), MAPK1(3), MYC(2), NODAL(1), PITX2(1), PPP2CA(2), PPP2CB(1), PPP2R1A(3), PPP2R1B(3), PPP2R2A(2), PPP2R2C(2), RBL1(4), RBL2(11), ROCK1(6), ROCK2(3), RPS6KB1(2), RPS6KB2(4), SMAD2(1), SMAD3(3), SMAD4(5), SMAD6(1), SMAD9(2), SMURF1(4), SMURF2(1), SP1(2), TFDP1(2), TGFB1(1), TGFB2(4), TGFB3(2), TGFBR1(1), TGFBR2(1), THBS1(6), THBS2(5), THBS3(6), THBS4(2), TNF(1), ZFYVE16(6), ZFYVE9(6) 55817335 200 130 197 51 18 44 25 65 45 3 0.145 1.000 1.000 489 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 105 ABL1(2), ANAPC1(4), ANAPC11(1), ANAPC2(5), ANAPC4(1), ANAPC5(1), ANAPC7(4), ATM(9), ATR(15), BUB1(2), BUB1B(2), CCNA1(3), CCNA2(4), CCNB1(2), CCNB2(1), CCNB3(4), CCND1(1), CCND2(3), CCNE1(1), CCNE2(2), CCNH(1), CDC14A(1), CDC14B(3), CDC16(1), CDC23(1), CDC25B(2), CDC25C(3), CDC7(5), CDK6(1), CDKN1B(5), CDKN1C(2), CDKN2B(1), CDKN2C(2), CHEK1(5), CHEK2(5), CREBBP(6), CUL1(2), E2F1(3), E2F3(2), EP300(11), ESPL1(2), FZR1(6), GADD45G(1), GSK3B(3), HDAC2(3), MAD1L1(2), MAD2L1(1), MCM2(5), MCM3(4), MCM4(3), MCM5(2), MCM6(2), MCM7(7), MDM2(1), PKMYT1(1), PLK1(2), PRKDC(6), PTTG1(3), RBL1(4), RBL2(11), SKP2(1), SMAD2(1), SMAD3(3), SMAD4(5), SMC1A(5), SMC1B(3), TFDP1(2), TGFB1(1), TGFB2(4), TGFB3(2), WEE1(2), YWHAE(1), YWHAZ(1) 75128831 229 128 223 39 14 43 18 90 63 1 0.00267 1.000 1.000 490 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 83 AGL(3), AMY2A(2), AMY2B(1), ASCC3(14), ATP13A2(3), DDX18(3), DDX23(2), DDX4(4), DDX41(1), DDX47(2), DDX50(7), DDX51(1), DDX52(1), DDX54(1), DDX55(1), DDX56(1), DHX58(1), ENPP1(1), ENPP3(4), ENTPD7(1), EP400(6), ERCC2(6), ERCC3(3), G6PC(3), GAA(2), GBE1(2), GPI(1), GUSB(8), GYS1(3), GYS2(5), HK1(3), HK2(3), HK3(5), LYZL1(1), MGAM(9), MOV10L1(1), NUDT5(1), PGM1(1), PGM3(2), PYGB(2), PYGL(2), PYGM(8), RAD54B(6), RUVBL2(1), SETX(8), SI(9), SKIV2L2(4), SMARCA2(9), SMARCA5(3), UGDH(2), UGP2(3), UGT1A1(3), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A9(1), UGT2A1(2), UGT2B11(1), UGT2B15(1), UGT2B17(1), UGT2B28(1), UGT2B4(5), UGT2B7(5) 74961060 203 124 198 76 12 56 16 57 59 3 0.983 1.000 1.000 491 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 69 A2M(5), BDKRB2(3), C1QA(3), C1QC(1), C2(4), C3(10), C3AR1(1), C4A(2), C4B(1), C4BPA(3), C4BPB(1), C5(5), C6(1), C7(1), C8A(4), C8B(4), C9(2), CD46(3), CD55(3), CFB(5), CFH(7), CFI(2), CPB2(2), CR1(9), CR2(9), F10(3), F11(1), F12(1), F13A1(2), F13B(1), F2(2), F2R(1), F3(1), F5(7), F8(5), FGA(12), FGB(3), KLKB1(3), KNG1(3), MASP1(2), MASP2(3), MBL2(1), PLAT(2), PLG(3), PROC(2), SERPINA1(1), SERPINA5(1), SERPINC1(2), SERPIND1(1), SERPINE1(1), SERPING1(3), TFPI(2), THBD(3), VWF(7) 59806826 170 122 169 48 7 39 28 51 45 0 0.348 1.000 1.000 492 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT1(2), AKT2(3), AKT3(2), CASP8(1), CCL3(1), CD40(3), CD80(4), CD86(2), CHUK(8), FADD(1), FOS(1), IFNA13(1), IFNA14(3), IFNA16(1), IFNA17(1), IFNA2(2), IFNA4(1), IFNA5(2), IFNA6(2), IFNA7(1), IFNA8(4), IFNAR1(2), IFNAR2(1), IFNB1(2), IKBKB(4), IKBKE(1), IL12A(6), IL12B(2), IL1B(1), IL6(2), IRAK1(5), IRAK4(4), IRF3(1), IRF5(1), IRF7(1), JUN(2), LBP(3), LY96(1), MAP2K2(2), MAP2K3(2), MAP2K4(4), MAP2K6(2), MAP2K7(2), MAP3K7(3), MAP3K8(1), MAPK1(3), MAPK10(3), MAPK11(1), MAPK12(1), MAPK14(3), MAPK8(1), MAPK9(3), MYD88(1), NFKB1(3), NFKB2(2), NFKBIA(2), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIK3R1(4), PIK3R2(4), PIK3R3(2), PIK3R5(1), RELA(4), RIPK1(4), STAT1(5), TBK1(1), TICAM1(1), TIRAP(2), TLR1(2), TLR2(1), TLR3(5), TLR4(5), TLR5(1), TLR6(4), TLR7(4), TLR8(7), TLR9(3), TNF(1), TRAF3(1), TRAF6(2) 49772757 201 121 199 48 8 54 29 58 52 0 0.157 1.000 1.000 493 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 85 ANPEP(3), CD19(2), CD1A(2), CD1B(4), CD1D(2), CD1E(3), CD22(5), CD33(1), CD36(3), CD37(2), CD38(3), CD3G(1), CD4(1), CD44(4), CD5(1), CD55(3), CD7(1), CD8A(1), CD8B(1), CD9(1), CR1(9), CR2(9), CSF1(2), CSF1R(1), CSF3R(1), EPOR(1), FCER2(1), FLT3(4), FLT3LG(2), GP1BB(1), HLA-DRA(1), HLA-DRB1(1), HLA-DRB5(1), IL11RA(1), IL1B(1), IL1R1(4), IL1R2(1), IL2RA(1), IL4(1), IL4R(1), IL5(1), IL5RA(1), IL6(2), IL6R(3), IL7(1), IL7R(1), IL9R(2), ITGA1(5), ITGA2(4), ITGA2B(3), ITGA3(5), ITGA4(5), ITGA5(4), ITGA6(3), ITGAM(6), ITGB3(5), KIT(12), KITLG(2), MME(6), TFRC(2), TNF(1), TPO(13) 47777826 175 119 173 57 8 42 21 64 39 1 0.758 1.000 1.000 494 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 79 ACVR1(2), ACVR1B(2), ACVRL1(1), AKT1(2), BMPR1A(1), BMPR2(5), BUB1(2), CDIPT(1), CDKL1(2), CDKL2(3), CDS1(2), CLK1(2), CLK2(5), CLK4(5), COL4A3BP(1), CSNK2A1(2), DGKA(4), DGKB(1), DGKD(3), DGKE(3), DGKG(5), DGKH(3), DGKQ(1), DGKZ(2), IMPA1(2), INPP4A(1), INPP4B(6), INPP5A(3), INPPL1(1), ITPKA(1), ITPKB(4), MAP3K10(1), MOS(2), NEK1(1), NEK3(1), OCRL(4), PAK4(2), PIK3C2A(4), PIK3C2B(8), PIK3C2G(7), PIK3CB(5), PIK3CG(3), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(9), PLCD1(2), PLCG1(7), PLCG2(7), PLK3(1), PRKACA(2), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), PRKCA(1), PRKCG(4), PRKCH(5), PRKCQ(3), PRKCZ(4), PRKD1(5), PRKG1(6), RAF1(2), RPS6KA1(1), RPS6KA2(5), RPS6KA4(2), RPS6KB1(2), STK11(1), TGFBR1(1) 63482198 209 117 203 58 12 51 24 59 63 0 0.511 1.000 1.000 495 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 A4GNT(1), ALG1(1), ALG10B(3), ALG11(1), ALG13(1), ALG14(1), ALG2(1), ALG6(1), ALG8(1), ALG9(1), B3GNT1(1), B3GNT2(1), B3GNT6(3), B3GNT7(1), B4GALT2(1), B4GALT3(2), B4GALT5(1), B4GALT7(1), C1GALT1(1), C1GALT1C1(1), CHPF(5), CHST11(2), CHST12(2), CHST13(3), CHST14(1), CHST2(3), CHST3(5), CHST6(2), CHST7(2), CHSY1(2), DDOST(1), EXT1(1), EXT2(4), EXTL1(2), EXTL3(2), FUT8(2), GALNT1(2), GALNT10(1), GALNT11(1), GALNT12(5), GALNT13(4), GALNT14(3), GALNT3(2), GALNT4(4), GALNT5(1), GALNT7(1), GALNT8(2), GALNT9(1), GALNTL5(4), GANAB(3), GCNT3(2), GCNT4(1), HS2ST1(3), HS3ST1(3), HS3ST2(1), HS3ST3A1(1), HS3ST5(4), HS6ST2(1), HS6ST3(1), MAN1A1(3), MAN1A2(3), MAN1B1(1), MAN1C1(1), MAN2A1(8), MGAT1(3), MGAT2(2), MGAT3(4), MGAT4A(2), MGAT5(4), MGAT5B(3), NDST1(2), NDST2(2), NDST3(4), NDST4(6), OGT(3), RPN1(1), RPN2(2), ST3GAL1(1), ST3GAL2(1), ST6GAL1(1), ST6GALNAC1(2), STT3B(4), UST(3), WBSCR17(7), XYLT1(3), XYLT2(1) 63290497 192 116 191 58 23 45 20 68 35 1 0.491 1.000 1.000 496 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(10), ACSL1(1), ACSL3(2), ACSL5(1), ACSL6(3), ADIPOQ(3), ADIPOR1(2), ADIPOR2(1), AGRP(2), AKT1(2), AKT2(3), AKT3(2), CAMKK1(1), CAMKK2(3), CD36(3), CHUK(8), CPT1A(4), CPT1B(4), CPT2(1), G6PC(3), IKBKB(4), IRS1(3), IRS2(2), IRS4(7), JAK2(4), JAK3(7), LEP(2), LEPR(4), MAPK10(3), MAPK8(1), MAPK9(3), NFKB1(3), NFKB2(2), NFKBIA(2), PCK1(6), PCK2(1), POMC(2), PPARA(3), PPARGC1A(6), PRKAA1(4), PRKAB2(1), PRKAG2(3), PRKAG3(2), PRKCQ(3), PTPN11(4), RELA(4), RXRA(2), RXRB(8), RXRG(2), SLC2A4(2), SOCS3(1), STAT3(4), STK11(1), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TYK2(1) 46582650 169 114 166 46 11 36 22 62 37 1 0.451 1.000 1.000 497 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CD2BP2(2), CDC40(2), CLK2(5), CLK3(2), CLK4(5), COL2A1(9), CPSF1(8), CPSF2(4), CPSF3(2), CPSF4(2), CSTF1(1), CSTF2(2), CSTF2T(2), CSTF3(1), DDX1(2), DDX20(3), DHX15(3), DHX16(3), DHX38(1), DHX8(6), DHX9(14), DICER1(7), DNAJC8(1), FUS(2), GIPC1(3), NCBP1(4), NCBP2(1), NONO(2), NXF1(3), PABPN1(1), PAPOLA(3), POLR2A(7), PPM1G(3), PRPF4(1), PRPF4B(2), PRPF8(8), PSKH1(4), PTBP1(4), PTBP2(2), RBM17(2), RBM5(4), RNGTT(2), RNMT(1), RNPS1(2), SF3A1(3), SF3A2(1), SF3A3(3), SF3B1(12), SF3B2(2), SF3B4(2), SNRPA(1), SNRPA1(2), SNRPB2(1), SNRPD3(1), SNRPN(4), SNURF(2), SPOP(4), SRPK1(1), SRPK2(1), SRRM1(4), SUPT5H(4), TXNL4A(1), U2AF2(4), XRN2(4) 60138465 205 114 200 45 13 42 13 74 62 1 0.113 1.000 1.000 498 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 78 ABL1(2), ATM(9), BUB1(2), BUB1B(2), CCNA1(3), CCNA2(4), CCNB1(2), CCNB2(1), CCNB3(4), CCND2(3), CCNE1(1), CCNE2(2), CCNH(1), CDAN1(4), CDC14A(1), CDC14B(3), CDC25B(2), CDC25C(3), CDC7(5), CDH1(7), CHEK1(5), CHEK2(5), DTX4(2), E2F1(3), E2F3(2), E2F4(2), E2F6(2), EP300(11), ESPL1(2), GSK3B(3), HDAC2(3), HDAC4(7), HDAC5(4), HDAC6(7), HDAC8(1), MAD1L1(2), MAD2L1(1), MCM2(5), MCM3(4), MCM4(3), MCM5(2), MCM6(2), MCM7(7), MDM2(1), MPEG1(4), MPL(1), PLK1(2), PRKDC(6), PTPRA(4), PTTG1(3), RBL1(4), SKP2(1), SMAD4(5), TBC1D8(3), TFDP1(2), TGFB1(1), WEE1(2) 61365235 185 113 179 30 13 30 18 75 48 1 0.00197 1.000 1.000 499 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 91 BCL2(1), CABIN1(5), CAMK2B(2), CD3G(1), CD69(2), CNR1(3), CREBBP(6), CSNK2A1(2), CTLA4(1), EGR2(1), EGR3(2), EP300(11), FCER1A(1), FOS(1), GATA3(1), GSK3A(1), GSK3B(3), IFNB1(2), IFNG(3), IL10(1), IL1B(1), IL2RA(1), IL4(1), IL6(2), ITK(1), JUNB(1), KPNA5(1), MAP2K7(2), MAPK14(3), MAPK8(1), MAPK9(3), MEF2A(6), MEF2D(3), MYF5(2), NCK2(2), NFAT5(6), NFATC1(2), NFATC2(7), NFATC3(4), NFATC4(5), NFKB2(2), NPPB(1), NUP214(9), P2RX7(1), PAK1(3), PIN1(2), PPP3CB(3), PTPRC(8), RELA(4), SLA(1), SP1(2), SP3(3), TGFB1(1), TNF(1), TRPV6(2), VAV1(3), VAV3(8), XPO5(4) 51976331 162 112 159 48 8 39 16 63 36 0 0.518 1.000 1.000 500 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 83 ATF2(1), CHUK(8), CREB1(1), DAXX(1), FOS(1), IKBKB(4), JUN(2), MAP2K2(2), MAP2K3(2), MAP2K4(4), MAP2K5(1), MAP2K6(2), MAP2K7(2), MAP3K1(3), MAP3K10(1), MAP3K11(1), MAP3K12(2), MAP3K13(4), MAP3K2(5), MAP3K3(1), MAP3K4(9), MAP3K5(1), MAP3K6(1), MAP3K7(3), MAP3K8(1), MAP3K9(3), MAP4K1(1), MAP4K2(4), MAP4K3(1), MAP4K4(4), MAP4K5(7), MAPK1(3), MAPK10(3), MAPK11(1), MAPK12(1), MAPK14(3), MAPK4(5), MAPK6(3), MAPK7(3), MAPK8(1), MAPK9(3), MAPKAPK2(1), MAPKAPK3(1), MAPKAPK5(3), MEF2A(6), MEF2C(1), MEF2D(3), MKNK1(2), MKNK2(3), MYC(2), NFKB1(3), NFKBIA(2), PAK1(3), PAK2(3), RAF1(2), RELA(4), RIPK1(4), RPS6KA1(1), RPS6KA2(5), RPS6KA4(2), RPS6KA5(5), RPS6KB1(2), RPS6KB2(4), SHC1(3), SP1(2), STAT1(5), TGFB1(1), TGFB2(4), TGFB3(2), TGFBR1(1) 55408329 189 112 186 42 14 49 21 63 41 1 0.0493 1.000 1.000 501 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 66 ADAM10(3), ADAM17(5), ATP6AP1(2), ATP6V0A1(6), ATP6V0A2(2), ATP6V0A4(3), ATP6V0C(2), ATP6V0D1(1), ATP6V0D2(1), ATP6V1A(2), ATP6V1B1(1), ATP6V1B2(2), ATP6V1C2(1), ATP6V1D(4), ATP6V1E1(1), ATP6V1F(2), ATP6V1H(1), CASP3(3), CDC42(3), CHUK(8), CSK(1), CXCL1(1), EGFR(6), F11R(1), GIT1(2), IGSF5(4), IKBKB(4), JAM2(3), JAM3(5), JUN(2), LYN(1), MAP2K4(4), MAPK10(3), MAPK11(1), MAPK12(1), MAPK14(3), MAPK8(1), MAPK9(3), MET(2), NFKB1(3), NFKB2(2), NFKBIA(2), NOD1(1), PAK1(3), PLCG1(7), PLCG2(7), PTPN11(4), PTPRZ1(11), RELA(4), SRC(3), TJP1(6) 40517055 154 108 151 31 6 34 17 56 41 0 0.130 1.000 1.000 502 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 59 AKT1(2), AKT2(3), AKT3(2), CDC42(3), CDKN1B(5), CREB1(1), CREB5(2), ERBB4(11), GAB1(3), GSK3A(1), GSK3B(3), IFI27(2), INPPL1(1), IRS1(3), IRS2(2), IRS4(7), MET(2), MYC(2), NOLC1(1), PAK1(3), PAK2(3), PAK3(3), PAK4(2), PAK6(2), PAK7(10), PARD3(3), PDK1(1), PIK3CD(5), PPP1R13B(4), PREX1(16), PTK2(9), RPS6KA1(1), RPS6KA2(5), RPS6KB1(2), SHC1(3), SLC2A4(2), SOS1(8), SOS2(4), TSC1(8), TSC2(12), YWHAE(1), YWHAZ(1) 40606660 164 108 159 34 16 37 18 56 36 1 0.0157 1.000 1.000 503 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 57 ASH1L(11), ASH2L(2), CTCFL(2), DOT1L(7), EED(2), EHMT1(4), EHMT2(5), EZH1(5), EZH2(2), FBXO11(4), HCFC1(4), HSF4(2), JMJD6(3), KDM6A(2), MEN1(3), NSD1(8), OGT(3), PAXIP1(2), PPP1CA(2), PPP1CC(1), PRDM2(4), PRDM6(2), PRDM7(1), PRDM9(2), PRMT1(2), PRMT5(2), PRMT6(3), PRMT7(1), PRMT8(3), RBBP5(2), SATB1(6), SETD1A(6), SETD1B(4), SETD2(17), SETD8(3), SETDB1(3), SETMAR(4), SMYD3(2), STK38(1), SUV39H1(1), SUV39H2(3), SUV420H1(6), SUZ12(3), WHSC1(5), WHSC1L1(6) 72117460 166 103 164 52 10 37 19 48 50 2 0.709 1.000 1.000 504 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 80 AIFM1(3), AKT1(2), AKT2(3), AKT3(2), APAF1(9), ATM(9), BAX(3), BCL2(1), BIRC2(4), BIRC3(1), CAPN1(2), CAPN2(1), CASP10(2), CASP3(3), CASP6(2), CASP8(1), CASP9(1), CFLAR(2), CHUK(8), CSF2RB(2), DFFB(1), FADD(1), FAS(3), IKBKB(4), IL1B(1), IL1R1(4), IL1RAP(1), IRAK1(5), IRAK3(3), IRAK4(4), MYD88(1), NFKB1(3), NFKB2(2), NFKBIA(2), NTRK1(5), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIK3R1(4), PIK3R2(4), PIK3R3(2), PIK3R5(1), PPP3CA(3), PPP3CB(3), PRKACA(2), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), RELA(4), RIPK1(4), TNF(1), TNFRSF10B(2), TNFRSF10D(2), TNFRSF1A(1), TNFSF10(1) 46399624 156 99 154 32 11 57 12 33 43 0 0.0447 1.000 1.000 505 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 56 BMP2(2), BMP4(1), BMP5(4), BMP6(2), BMP7(3), BTRC(5), CSNK1A1(2), CSNK1A1L(3), CSNK1E(3), CSNK1G1(2), FBXW11(1), GAS1(1), GLI1(5), GLI2(12), GLI3(11), GSK3B(3), HHIP(3), LRP2(18), PRKACA(2), PRKACB(2), PRKACG(2), PRKX(3), PTCH1(1), PTCH2(4), RAB23(2), SHH(1), SMO(1), STK36(2), SUFU(3), WNT1(2), WNT11(1), WNT2(3), WNT3A(2), WNT4(1), WNT5B(1), WNT6(1), WNT7A(2), WNT7B(1), WNT8A(2), WNT8B(1), WNT9A(2), WNT9B(2) 34801319 125 98 124 35 18 24 11 51 19 2 0.341 1.000 1.000 506 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(4), ADCY6(4), ADCY8(9), CACNA1A(9), CACNA1B(13), GNAS(10), GNAT3(4), GNB1(2), GRM4(4), ITPR3(11), KCNB1(2), PDE1A(2), PLCB2(3), PRKACA(2), PRKACB(2), PRKACG(2), PRKX(3), SCNN1A(1), SCNN1B(1), SCNN1G(5), TAS1R1(1), TAS1R2(3), TAS1R3(4), TAS2R1(1), TAS2R10(1), TAS2R13(2), TAS2R16(1), TAS2R3(1), TAS2R38(2), TAS2R39(2), TAS2R41(3), TAS2R42(2), TAS2R46(2), TAS2R50(1), TAS2R60(1), TAS2R7(2), TAS2R8(2), TAS2R9(1), TRPM5(3) 33586515 128 98 124 38 17 37 10 44 19 1 0.460 1.000 1.000 507 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(5), CREBBP(6), CTBP1(1), DLL1(2), DTX1(1), DTX2(2), DTX3(5), DTX3L(2), DTX4(2), DVL1(3), DVL2(6), DVL3(1), EP300(11), HDAC2(3), HES1(2), JAG1(2), JAG2(4), LFNG(7), MAML1(2), MAML2(2), MAML3(5), NCOR2(14), NCSTN(4), NOTCH1(7), NOTCH2(10), NOTCH3(12), NOTCH4(10), NUMB(3), NUMBL(1), PSEN1(2), PSEN2(2), PSENEN(1), RBPJ(1), RBPJL(1), SNW1(3) 41505231 145 97 141 42 21 30 13 50 31 0 0.446 1.000 1.000 508 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 51 ADORA3(2), ALG6(1), CCKBR(3), CCR2(1), CCR3(3), CCR5(2), CELSR1(12), CELSR2(10), CELSR3(11), CHRM2(5), CHRM3(7), CXCR3(3), EDNRA(1), EMR2(1), EMR3(4), F2R(1), FSHR(4), GHRHR(1), GPR116(4), GPR132(3), GPR133(1), GPR135(1), GPR143(1), GPR17(1), GPR55(1), GPR61(2), GPR84(5), GRM1(4), GRPR(1), HRH4(1), LGR6(5), LPHN2(3), LPHN3(12), P2RY13(1), PTGFR(2), SMO(1), SSTR2(1), TAAR5(1), TSHR(2), VN1R1(1) 37702467 126 90 125 35 9 34 10 52 21 0 0.378 1.000 1.000 509 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 42 ACTR2(1), AKT1(2), AKT2(3), AKT3(2), ANGPTL2(1), ARHGAP1(1), ARHGAP4(2), ARHGEF11(6), CDC42(3), CFL1(1), CFL2(2), GDI2(3), INPPL1(1), ITPR1(15), ITPR2(11), ITPR3(11), LIMK1(4), MYLK(3), MYLK2(2), PAK1(3), PAK2(3), PAK3(3), PAK4(2), PAK6(2), PAK7(10), PDK1(1), PIK3CD(5), PIK3CG(3), PIK3R1(4), PITX2(1), PPP1R13B(4), RACGAP1(5), RHO(3), ROCK1(6), ROCK2(3), SAG(2), WASF1(1), WASL(2) 38367531 137 90 136 34 15 31 11 48 32 0 0.242 1.000 1.000 510 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 45 FN3K(1), IMPA1(2), IMPA2(2), INPP4A(1), INPP4B(6), INPP5A(3), INPP5B(1), INPP5E(2), INPPL1(1), IPMK(1), ISYNA1(1), ITPK1(2), ITPKA(1), ITPKB(4), MINPP1(1), MIOX(1), OCRL(4), PI4KA(4), PI4KB(2), PIK3C3(2), PIK3CB(5), PIK3CD(5), PIK3CG(3), PIP4K2A(1), PIP4K2B(3), PIP4K2C(1), PIP5K1B(1), PLCB1(8), PLCB2(3), PLCB3(4), PLCB4(9), PLCD1(2), PLCD3(1), PLCD4(3), PLCE1(5), PLCG1(7), PLCG2(7), PLCZ1(3), PTPMT1(1), SYNJ1(7), SYNJ2(3) 41070904 124 88 120 38 9 28 18 35 34 0 0.508 1.000 1.000 511 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 65 AGTR1(2), ATP8A1(8), AVPR1A(3), AVPR1B(2), AVPR2(1), BDKRB2(3), C3AR1(1), CCKAR(1), CCKBR(3), CCR1(1), CCR2(1), CCR3(3), CCR4(1), CCR5(2), CCR6(5), CCR7(2), CCR8(1), CXCR3(3), CXCR4(2), EDNRA(1), EDNRB(2), FPR1(1), FSHR(4), GALR2(1), GHSR(2), GNB2L1(1), GRPR(1), LHCGR(6), MC2R(3), MC3R(2), MC4R(2), MC5R(1), NMBR(1), NPY1R(3), NPY2R(4), NPY5R(5), NTSR2(3), OPRK1(3), OPRL1(2), OPRM1(4), OXTR(1), SSTR2(1), SSTR4(3), TACR1(2), TACR2(2), TACR3(4), TRHR(3), TSHR(2) 28601769 115 87 112 35 13 20 11 54 17 0 0.445 1.000 1.000 512 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 51 ACTG1(1), APAF1(9), BAG4(1), BCL2(1), BIRC2(4), BIRC3(1), CASP3(3), CASP6(2), CASP8(1), CASP9(1), CFLAR(2), CHUK(8), CRADD(1), DAXX(1), DFFB(1), FADD(1), GSN(2), LMNA(2), LMNB2(2), MAP2K7(2), MAP3K1(3), MAP3K5(1), MAPK8(1), MDM2(1), NFKB1(3), NFKBIA(2), NUMA1(4), PAK2(3), PRKDC(6), PSEN1(2), PSEN2(2), PTK2(9), RASA1(10), RELA(4), RIPK1(4), SPTAN1(7), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRAF1(1) 38814789 112 83 112 31 2 31 7 32 40 0 0.636 1.000 1.000 513 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(5), AGPAT1(1), AGPAT2(2), AGPAT3(1), AGPAT4(1), AGPAT6(2), CDIPT(1), CDS1(2), CHAT(4), CHKA(1), CHPT1(1), CRLS1(1), DGKA(4), DGKB(1), DGKD(3), DGKE(3), DGKG(5), DGKH(3), DGKI(5), DGKQ(1), DGKZ(2), ESCO1(2), ESCO2(3), ETNK1(1), GNPAT(3), GPAM(5), GPD1L(1), LCAT(3), LYPLA1(1), NAT6(1), PCYT1A(3), PCYT1B(1), PHOSPHO1(1), PLA2G12B(1), PLA2G2D(1), PLA2G2F(5), PLA2G3(7), PLA2G4A(8), PLA2G6(3), PLD1(4), PLD2(3), PNPLA3(1), PPAP2A(3), PPAP2B(1), PPAP2C(2), PTDSS1(2), PTDSS2(2), SH3GLB1(2) 38122195 119 83 117 31 4 29 18 32 36 0 0.234 1.000 1.000 514 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 58 ALG2(1), BAX(3), CAD(4), CASP10(2), CASP3(3), CASP8(1), CD7(1), CSNK1A1(2), DAXX(1), DEDD2(3), DIABLO(1), EGFR(6), EPHB2(4), FADD(1), FAF1(2), FAIM2(1), HSPB1(1), MAP2K4(4), MAP2K7(2), MAP3K1(3), MAP3K5(1), MAPK1(3), MAPK10(3), MAPK8(1), MAPK8IP1(1), MAPK8IP3(2), MAPK9(3), MET(2), NFAT5(6), NFKB1(3), NFKB2(2), NFKBIA(2), NFKBIL1(1), NR0B2(4), PTPN13(14), RALBP1(1), RIPK1(4), ROCK1(6), SMPD1(4), TNFRSF6B(1), TPX2(3) 42236640 113 83 110 28 6 26 11 36 34 0 0.455 1.000 1.000 515 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(4), CSK(1), CTLA4(1), DAG1(1), EPHB2(4), FBXW7(3), GRAP2(3), ITK(1), ITPKA(1), ITPKB(4), LAT(1), LCK(4), LCP2(5), MAPK1(3), NCK1(1), NFAT5(6), NFKB1(3), NFKB2(2), NFKBIA(2), NFKBIL1(1), PAK1(3), PAK2(3), PAK3(3), PAK4(2), PAK6(2), PAK7(10), PLCG1(7), PTPRC(8), RAF1(2), RASGRP1(5), RASGRP3(1), RASGRP4(3), SOS1(8), SOS2(4), VAV1(3), ZAP70(3) 32702919 118 83 115 28 7 31 12 50 17 1 0.227 1.000 1.000 516 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(2), AANAT(2), ACAT1(2), ACAT2(5), ACMSD(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), AOC2(2), AOC3(1), AOX1(11), CAT(1), CYP1A1(3), CYP1B1(2), DDC(2), ECHS1(2), EHHADH(10), GCDH(1), HAAO(1), HADH(1), HADHA(3), HEMK1(3), HSD17B4(1), KMO(1), KYNU(3), LCMT2(3), MAOA(1), MAOB(8), METTL2B(5), METTL6(3), NFX1(4), OGDH(1), OGDHL(3), PRMT2(1), PRMT3(1), PRMT5(2), PRMT6(3), PRMT7(1), PRMT8(3), TPH1(2), TPH2(2), WARS(2), WARS2(1), WBSCR22(2) 34042511 115 82 115 30 5 29 16 38 26 1 0.224 1.000 1.000 517 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 26 EGFR(6), ERBB2(4), ERBB4(11), ETS1(2), ETS2(1), ETV6(1), ETV7(1), MAPK1(3), NOTCH1(7), NOTCH2(10), NOTCH3(12), NOTCH4(10), PIWIL1(4), PIWIL2(2), PIWIL3(5), PIWIL4(6), RAF1(2), SOS1(8), SOS2(4), SPIRE1(6), SPIRE2(1) 28297612 106 81 104 28 7 25 15 40 18 1 0.330 1.000 1.000 518 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 70 ADH1A(2), ADH1B(3), ADH4(3), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), AKR1C1(2), AKR1C2(1), AKR1C4(1), ALDH1A3(2), ALDH3B1(1), ALDH3B2(1), CYP1A1(3), CYP1B1(2), CYP2B6(5), CYP2C18(1), CYP2C8(3), CYP2C9(3), CYP2E1(4), CYP2F1(1), CYP2S1(1), CYP3A4(1), CYP3A43(1), CYP3A5(4), DHDH(3), EPHX1(4), GSTA2(1), GSTA4(1), GSTA5(1), GSTK1(1), GSTM3(1), GSTM5(1), GSTP1(2), GSTZ1(2), MGST2(1), UGT1A1(3), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A9(1), UGT2A1(2), UGT2B11(1), UGT2B15(1), UGT2B17(1), UGT2B28(1), UGT2B4(5), UGT2B7(5) 32183919 96 77 94 24 3 27 3 30 33 0 0.600 1.000 1.000 519 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 56 APC(12), CCND1(1), CCND2(3), CSNK1E(3), DVL1(3), DVL2(6), DVL3(1), FBXW2(3), FZD1(2), FZD10(1), FZD2(4), FZD3(2), FZD6(2), FZD7(3), FZD8(2), FZD9(3), GSK3B(3), JUN(2), LDLR(2), MAPK10(3), MAPK9(3), MYC(2), PAFAH1B1(1), PPP2R5C(3), PPP2R5E(1), PRKCA(1), PRKCG(4), PRKCH(5), PRKCQ(3), PRKCZ(4), PRKD1(5), TCF7(2), WNT1(2), WNT11(1), WNT2(3), WNT4(1), WNT5B(1), WNT6(1), WNT7A(2), WNT7B(1) 31288352 107 77 105 28 10 21 9 41 25 1 0.337 1.000 1.000 520 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(2), AK3(1), CAD(4), CDA(3), CTPS2(1), DCTD(1), DHODH(1), DPYD(6), DPYS(1), DUT(1), ENTPD1(3), ENTPD5(1), ENTPD6(3), NME1(2), NME2(1), NME6(2), NME7(1), NT5C1B(3), NT5C2(1), NT5E(1), NT5M(2), PNPT1(3), POLA1(4), POLD1(4), POLD4(1), POLE(4), POLE2(4), POLE3(1), POLR1A(7), POLR1B(2), POLR1C(1), POLR2A(7), POLR2B(6), POLR2G(2), POLR2H(1), POLR2I(2), POLR3A(3), POLR3B(2), POLR3H(1), PRIM1(3), RFC5(2), RRM1(5), TK1(2), TK2(1), TYMS(1), UCK2(1), UMPS(1), UPB1(1), UPP1(1), UPP2(1), UPRT(1), ZNRD1(1) 46347528 117 73 117 27 10 29 8 34 35 1 0.164 1.000 1.000 521 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 44 AGL(3), AMY2A(2), AMY2B(1), ENPP1(1), ENPP3(4), G6PC(3), GAA(2), GANAB(3), GBE1(2), GPI(1), GUSB(8), GYS1(3), GYS2(5), HK1(3), HK2(3), HK3(5), MGAM(9), PGM1(1), PGM3(2), PYGB(2), PYGL(2), PYGM(8), SI(9), UCHL1(1), UCHL3(2), UGDH(2), UGT1A1(3), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A9(1), UGT2B15(1), UGT2B4(5) 37795366 104 73 101 35 4 27 10 30 32 1 0.827 1.000 1.000 522 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(5), AGPAT1(1), AGPAT2(2), AGPAT3(1), AGPAT4(1), AGPS(3), CDIPT(1), CDS1(2), CHAT(4), CHKA(1), CLC(1), CPT1B(4), DGKA(4), DGKB(1), DGKD(3), DGKE(3), DGKG(5), DGKH(3), DGKQ(1), DGKZ(2), ETNK1(1), GNPAT(3), LCAT(3), LYPLA1(1), PAFAH1B1(1), PCYT1A(3), PCYT1B(1), PLA2G3(7), PLA2G4A(8), PLA2G6(3), PLCB2(3), PLCG1(7), PLCG2(7), PPAP2A(3), PPAP2B(1), PPAP2C(2) 29209202 102 72 99 28 5 25 11 30 31 0 0.387 1.000 1.000 523 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 AK3(1), CAD(4), CDA(3), CTPS2(1), DCTD(1), DHODH(1), DPYD(6), DPYS(1), DUT(1), ENTPD1(3), NME1(2), NME2(1), NT5E(1), NT5M(2), POLB(2), POLD1(4), POLE(4), POLG(5), POLL(1), POLQ(17), POLR1B(2), POLR2A(7), POLR2B(6), POLR2G(2), POLR2H(1), POLR2I(2), POLRMT(1), RRM1(5), TK1(2), TK2(1), TYMS(1), UCK2(1), UMPS(1), UNG(3), UPB1(1), UPP1(1) 32876642 98 72 98 24 8 25 11 32 22 0 0.181 1.000 1.000 524 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(1), ALPL(1), ALPP(4), ALPPL2(2), ASCC3(14), ATP13A2(3), DDX18(3), DDX23(2), DDX4(4), DDX41(1), DDX47(2), DDX50(7), DDX51(1), DDX52(1), DDX54(1), DDX55(1), DDX56(1), DHX58(1), ENTPD7(1), EP400(6), ERCC2(6), ERCC3(3), FPGS(1), MOV10L1(1), NUDT5(1), PTS(2), RAD54B(6), RUVBL2(1), SETX(8), SKIV2L2(4), SMARCA2(9), SMARCA5(3) 35900888 102 71 101 40 8 31 8 28 25 2 0.956 1.000 1.000 525 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(2), ADH1B(3), ADH4(3), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), AGK(1), AGPAT1(1), AGPAT2(2), AGPAT3(1), AGPAT4(1), AGPAT6(2), AKR1B1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), CEL(3), DAK(3), DGAT1(4), DGKA(4), DGKB(1), DGKD(3), DGKE(3), DGKG(5), DGKH(3), DGKI(5), DGKQ(1), DGKZ(2), GK(1), GK2(1), GLA(1), GLB1(3), GPAM(5), LCT(6), LIPA(1), LIPC(2), LIPF(2), LIPG(2), LPL(1), MGLL(4), PNLIP(1), PNLIPRP1(3), PNPLA3(1), PPAP2A(3), PPAP2B(1), PPAP2C(2) 33927171 107 70 106 33 2 24 17 33 31 0 0.680 1.000 1.000 526 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 41 BCL2(1), CHUK(8), DAXX(1), EGF(6), EGFR(6), ETS1(2), ETS2(1), FOS(1), HOXA7(2), IKBKB(4), JUN(2), MAP2K3(2), MAP2K4(4), MAP2K6(2), MAP2K7(2), MAP3K1(3), MAP3K5(1), MAPK1(3), MAPK14(3), MAPK8(1), NFKB1(3), NFKBIA(2), PPP2CA(2), PRKCA(1), PRKCG(4), PRKCH(5), PRKCQ(3), RAF1(2), RELA(4), RIPK1(4), SP1(2), TNF(1), TNFRSF1A(1), TNFRSF1B(1) 26714068 90 70 88 24 1 19 12 34 24 0 0.644 1.000 1.000 527 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(10), ACACB(10), ACAT1(2), ACAT2(5), ACOT12(5), ACSS1(2), ACSS2(1), ACYP1(1), AKR1B1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), DLD(4), GLO1(2), HAGH(1), HAGHL(4), LDHA(1), LDHAL6A(2), LDHAL6B(2), LDHB(1), LDHC(1), LDHD(1), MDH1(1), ME1(1), ME2(3), ME3(1), PC(3), PCK1(6), PCK2(1), PDHA1(1), PDHA2(3), PDHB(2), PKLR(3) 26181407 88 68 88 26 7 22 9 29 20 1 0.476 1.000 1.000 528 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(2), AASS(5), ACAT1(2), ACAT2(5), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), BBOX1(3), DLST(1), DOT1L(7), ECHS1(2), EHHADH(10), EHMT1(4), EHMT2(5), GCDH(1), HADH(1), HADHA(3), HSD17B4(1), HSD3B7(1), NSD1(8), OGDH(1), OGDHL(3), PLOD1(1), PLOD2(6), PLOD3(1), RDH11(1), RDH13(1), RDH14(1), SETD1A(6), SETDB1(3), SHMT1(2), SHMT2(4), SPCS3(2), SUV39H1(1), SUV39H2(3) 32753892 104 66 103 29 5 25 16 29 29 0 0.401 1.000 1.000 529 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(2), ACSS2(1), ACYP1(1), ADH1A(2), ADH1B(3), ADH4(3), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3B1(1), ALDH3B2(1), ALDH7A1(1), ALDH9A1(1), ALDOB(1), DLD(4), ENO1(2), ENO3(1), FBP1(1), FBP2(2), G6PC(3), GAPDHS(2), GPI(1), HK1(3), HK2(3), HK3(5), LDHA(1), LDHAL6A(2), LDHAL6B(2), LDHB(1), LDHC(1), PDHA1(1), PDHA2(3), PDHB(2), PFKL(1), PFKM(1), PFKP(2), PGAM4(1), PGK2(2), PGM1(1), PGM3(2), PKLR(3), TPI1(1) 32698784 82 63 81 31 5 15 10 28 24 0 0.849 1.000 1.000 530 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA2(1), ACADL(2), ACADM(1), ACADVL(2), ACAT1(2), ACAT2(5), ACOX1(2), ACOX3(1), ACSL1(1), ACSL3(2), ACSL5(1), ACSL6(3), ADH1A(2), ADH1B(3), ADH4(3), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), CPT1A(4), CPT1B(4), CPT2(1), CYP4A11(3), CYP4A22(5), ECHS1(2), EHHADH(10), GCDH(1), HADH(1), HADHA(3), HADHB(4), HSD17B4(1) 27574408 83 60 83 24 1 20 11 30 21 0 0.455 1.000 1.000 531 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC7(5), CDT1(1), DIAPH2(2), GMNN(1), MCM10(7), MCM2(5), MCM3(4), MCM4(3), MCM5(2), MCM6(2), MCM7(7), NACA(5), POLD1(4), POLD4(1), POLE(4), POLE2(4), PRIM1(3), RFC1(7), RFC2(5), RFC4(1), RFC5(2), RPA1(1), RPA2(2), RPS27A(1), UBA52(1), UBC(1) 28794673 81 58 78 21 6 15 8 32 20 0 0.271 1.000 1.000 532 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(1), B3GALNT1(1), B3GALT1(1), B3GALT4(1), B3GALT5(2), B3GNT1(1), B3GNT2(1), B3GNT4(2), B3GNT5(1), B4GALNT1(1), B4GALT2(1), B4GALT3(2), B4GALT6(2), FUT1(4), FUT3(2), FUT5(1), FUT7(2), FUT9(4), GBGT1(3), GCNT2(1), PIGA(1), PIGB(1), PIGC(2), PIGL(2), PIGM(4), PIGN(6), PIGO(2), PIGQ(3), PIGS(5), PIGV(2), PIGZ(4), ST3GAL1(1), ST3GAL2(1), ST3GAL6(1), ST6GALNAC3(2), ST6GALNAC5(3), ST8SIA5(2) 27880022 76 58 76 22 7 12 9 31 17 0 0.562 1.000 1.000 533 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(2), AKT2(3), AKT3(2), ARHGEF11(6), BCL2(1), CDC42(3), GNA13(1), LPA(5), MAP2K4(4), MAP3K1(3), MAP3K5(1), MAPK8(1), NFKB1(3), NFKB2(2), NFKBIA(2), NFKBIL1(1), PDK1(1), PHKA2(3), PIK3CB(5), PLD1(4), PLD2(3), PLD3(4), PTK2(9), RDX(1), ROCK1(6), ROCK2(3), SERPINA4(2), SRF(1) 28120719 82 58 81 26 3 22 10 21 26 0 0.745 1.000 1.000 534 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(4), POLB(2), POLD1(4), POLD4(1), POLE(4), POLE2(4), POLE3(1), POLG(5), POLG2(2), POLI(1), POLK(2), POLL(1), POLM(1), POLQ(17), PRIM1(3), REV1(6), REV3L(13), RFC5(2) 23426387 73 57 72 23 4 19 6 24 20 0 0.587 1.000 1.000 535 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(9), BMPR1B(2), CCND2(3), CDKN1B(5), DAZL(1), ESR2(1), FSHR(4), GJA4(1), INHA(2), LHCGR(6), MLH1(2), MSH5(3), NCOR1(10), NR5A1(2), NRIP1(1), PGR(5), PRLR(1), PTGER2(3), SMPD1(4), ZP2(2) 19572694 67 57 65 20 8 11 4 25 17 2 0.600 1.000 1.000 536 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(4), EGF(6), EGFR(6), MAPK1(3), PTPRB(14), RAF1(2), RASA1(10), SHC1(3), SOS1(8), SPRY1(3), SPRY2(3), SPRY3(1), SPRY4(1), SRC(3) 14144379 67 57 66 22 3 16 9 23 15 1 0.765 1.000 1.000 537 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(2), ADH1B(3), ADH4(3), ADH6(1), ADH7(1), ADHFE1(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3B1(1), ALDH3B2(1), ALDH9A1(1), ALDOB(1), DLD(4), ENO1(2), ENO3(1), FBP1(1), FBP2(2), G6PC(3), GPI(1), HK1(3), HK2(3), HK3(5), LDHA(1), LDHB(1), LDHC(1), PDHA1(1), PDHA2(3), PDHB(2), PFKM(1), PFKP(2), PGM1(1), PGM3(2), PKLR(3), TPI1(1) 27366083 68 56 68 28 4 13 8 24 19 0 0.891 1.000 1.000 538 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(2), ADH1B(3), ADH4(3), ADH6(1), ADH7(1), ADHFE1(2), AGPAT1(1), AGPAT2(2), AGPAT3(1), AGPAT4(1), AKR1B1(1), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH9A1(1), CEL(3), DGAT1(4), DGKA(4), DGKB(1), DGKD(3), DGKE(3), DGKG(5), DGKH(3), DGKQ(1), DGKZ(2), GK(1), GLA(1), GLB1(3), LCT(6), LIPC(2), LIPF(2), LIPG(2), LPL(1), PNLIP(1), PNLIPRP1(3), PPAP2A(3), PPAP2B(1), PPAP2C(2) 28001003 83 56 82 22 2 19 14 25 23 0 0.376 1.000 1.000 539 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(2), ADH1B(3), ADH4(3), ADH6(1), ADH7(1), ADHFE1(2), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3B1(1), ALDH3B2(1), ALDH9A1(1), ALDOB(1), DLD(4), ENO1(2), ENO3(1), FBP1(1), FBP2(2), G6PC(3), GPI(1), HK1(3), HK2(3), HK3(5), LDHA(1), LDHB(1), LDHC(1), PDHA1(1), PDHA2(3), PDHB(2), PFKM(1), PFKP(2), PGM1(1), PGM3(2), PKLR(3), TPI1(1) 27366083 68 56 68 28 4 13 8 24 19 0 0.891 1.000 1.000 540 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(1), ACTR2(1), AKT1(2), ANGPTL2(1), CDC42(3), CFL1(1), CFL2(2), FLNA(4), FLNC(5), FSCN1(1), GDI2(3), LIMK1(4), MYH2(7), MYLK(3), MYLK2(2), PAK1(3), PAK2(3), PAK3(3), PAK4(2), PAK6(2), PAK7(10), RHO(3), ROCK1(6), ROCK2(3), VASP(2), WASF1(1), WASL(2) 27449486 80 56 80 33 7 16 6 32 19 0 0.969 1.000 1.000 541 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSD(3), ARSE(2), ASAH1(2), B4GALT6(2), DEGS1(1), ENPP7(1), GALC(3), GLA(1), GLB1(3), LCT(6), NEU1(2), NEU2(4), NEU3(2), NEU4(2), PPAP2A(3), PPAP2B(1), PPAP2C(2), SGMS1(4), SGMS2(1), SGPP1(1), SGPP2(2), SMPD1(4), SMPD2(4), SMPD3(1), SMPD4(3), SPHK1(7), SPHK2(3), SPTLC2(1) 20373997 71 55 68 22 7 20 14 15 15 0 0.394 1.000 1.000 542 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(2), AADAC(1), ABAT(3), ACAT1(2), ACAT2(5), ACSM1(3), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH5A1(1), ALDH7A1(1), ALDH9A1(1), BDH1(2), BDH2(1), DDHD1(2), ECHS1(2), EHHADH(10), GAD1(5), GAD2(1), HADH(1), HADHA(3), HMGCL(2), HMGCS1(2), HMGCS2(2), HSD17B4(1), HSD3B7(1), L2HGDH(2), OXCT1(2), PDHA1(1), PDHA2(3), PDHB(2), PLA1A(2), PRDX6(1), RDH11(1), RDH13(1), RDH14(1) 23301268 75 55 74 28 4 19 8 28 16 0 0.808 1.000 1.000 543 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOB(1), DLD(4), ENO1(2), ENO3(1), FBP1(1), FBP2(2), G6PC(3), GAPDHS(2), GPI(1), HK1(3), HK2(3), HK3(5), LDHA(1), LDHAL6B(2), LDHB(1), LDHC(1), MDH1(1), PC(3), PCK1(6), PDHA1(1), PDHA2(3), PDHB(2), PDHX(3), PFKL(1), PFKM(1), PFKP(2), PGK2(2), PKLR(3), TPI1(1) 23589659 62 52 61 27 5 13 8 20 15 1 0.925 1.000 1.000 544 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(3), BLVRA(1), COX10(1), CP(6), CPOX(1), EPRS(4), FECH(1), FTMT(5), GUSB(8), HCCS(2), HMBS(4), HMOX1(1), PPOX(3), UGT1A1(3), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT1A9(1), UGT2A1(2), UGT2B11(1), UGT2B15(1), UGT2B17(1), UGT2B28(1), UGT2B4(5), UGT2B7(5) 22757490 67 52 65 19 1 12 3 23 28 0 0.842 1.000 1.000 545 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(1), ALDOB(1), FBP1(1), FBP2(2), FPGT(3), FUK(2), GMPPA(5), GMPPB(1), HK1(3), HK2(3), HK3(5), HSD3B7(1), LHPP(1), MPI(2), MTMR1(2), MTMR2(1), MTMR6(4), PFKFB1(5), PFKFB2(3), PFKFB3(2), PFKFB4(1), PFKL(1), PFKM(1), PFKP(2), PGM2(3), PHPT1(1), PMM1(1), RDH11(1), RDH13(1), RDH14(1), SORD(1), TPI1(1), TSTA3(3) 21381540 66 51 65 25 5 14 8 22 17 0 0.810 1.000 1.000 546 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(2), ACP2(1), ACP5(1), ACPP(6), ACPT(1), ALPI(1), ALPL(1), ALPP(4), ALPPL2(2), CYP19A1(1), CYP1A1(3), CYP2A13(2), CYP2A6(3), CYP2A7(4), CYP2B6(5), CYP2C18(1), CYP2C8(3), CYP2C9(3), CYP2D6(1), CYP2E1(4), CYP2F1(1), CYP3A4(1), CYP3A5(4), CYP4B1(6), PON1(1) 16707965 62 49 62 19 2 18 5 19 18 0 0.696 1.000 1.000 547 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(3), AARS2(3), CARS(2), CARS2(1), DARS(1), EPRS(4), FARS2(1), FARSA(2), FARSB(1), GARS(1), HARS(1), HARS2(1), IARS(5), IARS2(3), LARS(1), LARS2(2), MARS(6), MTFMT(1), NARS2(2), PARS2(1), QARS(1), RARS(3), RARS2(1), SARS2(2), TARS(2), TARS2(4), VARS(2), VARS2(1), WARS(2), WARS2(1) 30380376 61 49 61 29 2 17 4 14 24 0 0.996 1.000 1.000 548 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(2), FUCA1(1), FUCA2(1), GALNS(1), GLB1(3), GUSB(8), HEXA(3), HEXB(1), HGSNAT(4), HPSE(1), HPSE2(2), HYAL1(1), IDS(1), IDUA(1), LCT(6), MAN2B1(2), MAN2B2(3), MAN2C1(5), MANBA(1), NAGLU(3), NEU1(2), NEU2(4), NEU3(2), NEU4(2), SPAM1(4) 20371972 64 49 61 21 6 14 11 19 14 0 0.483 1.000 1.000 549 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 ANKHD1(9), EEF1D(1), EEF1G(2), EEF2(2), EEF2K(1), EIF2AK1(1), EIF2AK2(1), EIF2AK3(3), EIF2B2(2), EIF2B3(2), EIF2B4(1), EIF2B5(1), EIF2S2(1), EIF2S3(1), EIF4A2(3), EIF4EBP2(1), EIF4G1(7), EIF4G3(6), EIF5(1), EIF5A(2), EIF5B(1), ETF1(1), PABPC3(3), SLC35A4(1) 25166782 54 49 53 21 5 15 10 12 11 1 0.820 1.000 1.000 550 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 21 F10(3), F11(1), F12(1), F13B(1), F2(2), F5(7), F8(5), FGA(12), FGB(3), LPA(5), PLAT(2), PLG(3), SERPINB2(3), SERPINE1(1), VWF(7) 20342162 56 47 55 20 1 19 12 14 10 0 0.643 1.000 1.000 551 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(1), B4GALT2(1), FBP2(2), G6PC(3), GAA(2), GALK1(3), GALK2(1), GANAB(3), GLA(1), GLB1(3), HK1(3), HK2(3), HK3(5), LCT(6), MGAM(9), PFKM(1), PFKP(2), PGM1(1), PGM3(2) 18379069 52 47 50 21 4 11 8 18 11 0 0.800 1.000 1.000 552 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(1), B4GALT2(1), G6PC(3), GAA(2), GALK1(3), GALK2(1), GLA(1), GLB1(3), HK1(3), HK2(3), HK3(5), HSD3B7(1), LCT(6), MGAM(9), PFKL(1), PFKM(1), PFKP(2), PGM1(1), PGM3(2), RDH11(1), RDH13(1), RDH14(1), UGP2(3) 21793829 55 47 53 27 5 11 8 18 13 0 0.965 1.000 1.000 553 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(3), AARS2(3), ABAT(3), ACY3(1), ADSL(2), ADSS(2), AGXT(3), AGXT2(1), ASL(1), ASNS(3), ASRGL1(1), ASS1(3), CAD(4), CRAT(2), DARS(1), DLD(4), GAD1(5), GAD2(1), GPT(1), GPT2(2), NARS2(2), PC(3), PDHA1(1), PDHA2(3), PDHB(2) 21482296 57 47 57 22 5 19 9 17 7 0 0.748 1.000 1.000 554 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 38 ANAPC1(4), ANAPC11(1), ANAPC2(5), ANAPC4(1), ANAPC5(1), ANAPC7(4), BTRC(5), CDC16(1), CDC23(1), CUL1(2), CUL2(3), CUL3(2), FBXW11(1), FBXW7(3), FZR1(6), ITCH(1), SKP2(1), SMURF1(4), SMURF2(1), UBA1(3), UBE2C(1), UBE2D1(1), UBE2D2(1), UBE2D3(4), UBE2E1(1), UBE2E2(1), WWP1(3), WWP2(1) 22459421 63 47 63 17 5 21 5 12 20 0 0.307 1.000 1.000 555 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(1), ARHGAP1(1), ARHGAP4(2), ARHGAP5(3), ARHGAP6(2), ARHGEF1(1), ARHGEF11(6), ARHGEF5(1), ARPC1A(1), ARPC1B(2), ARPC2(3), ARPC3(1), BAIAP2(1), CFL1(1), DIAPH1(5), GSN(2), LIMK1(4), MYLK(3), PIP5K1B(1), PPP1R12B(4), ROCK1(6), SRC(3), TLN1(10), VCL(3) 27198006 67 47 67 18 3 15 7 24 18 0 0.507 1.000 1.000 556 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 27 BAG4(1), CASP3(3), CASP8(1), CRADD(1), DFFB(1), FADD(1), JUN(2), LMNA(2), LMNB2(2), MADD(4), MAP2K4(4), MAP3K1(3), MAP3K7(3), MAPK8(1), PAK1(3), PAK2(3), PRKDC(6), RIPK1(4), SPTAN1(7), TNF(1), TNFRSF1A(1) 21635992 54 47 54 16 1 9 5 14 25 0 0.746 1.000 1.000 557 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA2(1), ACADL(2), ACADM(1), ACAT1(2), ACAT2(5), ALDH1A1(1), ALDH1A2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH6A1(1), ALDH9A1(1), AOX1(11), BCAT1(2), BCKDHA(1), ECHS1(2), EHHADH(10), HADHA(3), HADHB(4), HIBADH(1), HMGCL(2), IVD(1), MCCC1(5), MCCC2(2), MUT(4), OXCT1(2), PCCA(1), PCCB(1), SDS(2) 20505019 74 47 73 25 0 22 7 25 20 0 0.743 1.000 1.000 558 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 26 ACLY(3), ACO1(6), ACO2(3), CLYBL(1), CS(4), DLD(4), DLST(1), FH(3), IDH2(4), IDH3G(2), MDH1(1), OGDH(1), OGDHL(3), PC(3), PCK1(6), PCK2(1), SDHA(2), SDHB(1), SUCLA2(2), SUCLG1(1), SUCLG2(1) 16260692 53 46 52 18 3 8 11 13 17 1 0.730 1.000 1.000 559 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CHUK(8), EGR2(1), EGR3(2), GNAQ(1), MAP3K1(3), MYC(2), NFATC1(2), NFATC2(7), NFKB1(3), NFKBIA(2), PLCG1(7), PPP3CA(3), PPP3CB(3), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), RELA(4), SYT1(2), VIPR2(2) 15696890 60 46 59 19 5 13 5 23 14 0 0.815 1.000 1.000 560 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 CHIA(3), CMAS(1), CTBS(1), CYB5R3(1), GFPT1(1), GFPT2(2), GNE(2), GNPDA2(2), GNPNAT1(1), HEXA(3), HEXB(1), HK1(3), HK2(3), HK3(5), LHPP(1), MTMR1(2), MTMR2(1), MTMR6(4), NAGK(3), NANS(1), NPL(1), PGM3(2), PHPT1(1), UAP1(1) 16325440 46 42 46 22 2 9 5 17 13 0 0.951 1.000 1.000 561 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL3(1), CCR1(1), CCR2(1), CCR3(3), CCR4(1), CCR5(2), CCR7(2), CD4(1), CXCR3(3), CXCR4(2), IFNG(3), IFNGR1(3), IFNGR2(1), IL12A(6), IL12B(2), IL12RB1(3), IL12RB2(5), IL18R1(2), IL4(1), IL4R(1), IL5(1), TGFB1(1), TGFB2(4), TGFB3(2) 11361878 52 42 52 17 3 14 4 25 6 0 0.643 1.000 1.000 562 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 20 GRIN1(5), GRIN2A(6), GRIN2B(3), GRIN2C(5), GRIN2D(2), NOS1(14), PPP3CA(3), PPP3CB(3), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), PRKCA(1), SYT1(2) 13867086 52 42 52 21 5 14 4 20 9 0 0.935 1.000 1.000 563 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 16 CHUK(8), CREBBP(6), EP300(11), FADD(1), IKBKB(4), NFKB1(3), NFKBIA(2), RELA(4), RIPK1(4), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRAF6(2) 13052823 48 41 47 17 0 18 4 18 8 0 0.807 1.000 1.000 564 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 37 CCNH(1), ERCC3(3), GTF2B(3), GTF2E1(3), GTF2H4(3), POLR1A(7), POLR1B(2), POLR2A(7), POLR2B(6), POLR2G(2), POLR2H(1), POLR2I(2), POLR3B(2), POLR3D(2), POLR3E(2), POLR3H(1), TAF6(4), TBP(1) 19943989 52 40 51 14 3 14 6 11 18 0 0.295 1.000 1.000 565 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSD(3), ARSE(2), ASAH1(2), GALC(3), GLA(1), GLB1(3), LCT(6), NEU1(2), NEU2(4), NEU3(2), NEU4(2), PPAP2A(3), PPAP2B(1), PPAP2C(2), SMPD1(4), SMPD2(4), SPTLC2(1) 13840982 45 39 43 20 3 13 9 11 9 0 0.864 1.000 1.000 566 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(10), ACACB(10), FASN(18), MCAT(2), OXSM(3) 9366085 43 39 43 15 5 9 6 15 8 0 0.639 1.000 1.000 567 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA2(1), ACAD8(2), ADH1A(2), ADH1B(3), ADH4(3), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), AKR1C4(1), AKR1D1(3), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), BAAT(1), CEL(3), CYP27A1(4), CYP7A1(1), HADHB(4), HSD3B7(1), LIPA(1), RDH11(1), RDH13(1), RDH14(1), SLC27A5(3), SOAT2(1), SRD5A1(1) 18095693 51 39 51 17 6 13 4 18 10 0 0.632 1.000 1.000 568 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 29 ANXA1(1), ANXA2(1), ANXA3(4), ANXA6(1), CYP11A1(1), EDN1(2), EDNRA(1), EDNRB(2), HPGD(3), HSD11B1(2), PLA2G4A(8), PRL(3), PTGER1(1), PTGER2(3), PTGER4(1), PTGFR(2), PTGIR(2), PTGIS(2), PTGS1(2), PTGS2(3) 12525829 45 39 43 14 5 7 5 18 10 0 0.646 1.000 1.000 569 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(3), ALDH4A1(1), ALDH5A1(1), CAD(4), CPS1(12), EPRS(4), GAD1(5), GAD2(1), GCLC(1), GCLM(1), GFPT1(1), GLS(4), GLS2(1), GLUD1(3), GLUL(1), GMPS(4), GPT(1), GPT2(2), GSS(1), PPAT(4), QARS(1) 18871065 56 38 55 16 2 16 5 15 18 0 0.514 1.000 1.000 570 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(10), C5(5), C6(1), C7(1), ICAM1(1), IL6(2), ITGA4(5), ITGAL(5), ITGB2(8), SELP(1), SELPLG(1), TNF(1), VCAM1(3) 13872000 44 38 43 19 2 13 3 14 12 0 0.919 1.000 1.000 571 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 15 AGT(1), EDN1(2), EDNRA(1), EDNRB(2), EGF(6), EGFR(6), FOS(1), JUN(2), MYC(2), NFKB1(3), PLCG1(7), PRKCA(1), RELA(4) 10407520 38 36 36 15 1 11 4 12 10 0 0.939 1.000 1.000 572 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 15 C1QA(3), C2(4), C3(10), C4A(2), C4B(1), C5(5), C6(1), C7(1), C8A(4), C8B(4), C9(2), MASP1(2) 19299824 39 36 39 13 3 10 5 8 13 0 0.673 1.000 1.000 573 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 16 C1QA(3), C2(4), C3(10), C4A(2), C4B(1), C5(5), C6(1), C7(1), C8A(4), C9(2), MASP1(2), MASP2(3), MBL2(1) 19684768 39 36 39 15 3 8 6 7 15 0 0.864 1.000 1.000 574 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(1), ALDOB(1), FBP1(1), FBP2(2), FPGT(3), GMPPA(5), GMPPB(1), HK1(3), HK2(3), HK3(5), MPI(2), PFKFB1(5), PFKFB3(2), PFKFB4(1), PFKM(1), PFKP(2), PMM1(1), SORD(1), TPI1(1) 13690096 41 36 41 16 3 7 8 13 10 0 0.708 1.000 1.000 575 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 GALNS(1), GLB1(3), GUSB(8), HEXA(3), HEXB(1), HGSNAT(4), HPSE(1), HPSE2(2), HYAL1(1), IDS(1), IDUA(1), LCT(6), NAGLU(3), SPAM1(4) 12075355 39 34 36 14 2 7 9 12 9 0 0.538 1.000 1.000 576 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(3), ABAT(3), ADSL(2), ADSS(2), AGXT(3), AGXT2(1), ASL(1), ASNS(3), CAD(4), CRAT(2), DARS(1), GAD1(5), GAD2(1), GPT(1), GPT2(2), PC(3) 14728794 37 33 37 15 3 13 5 11 5 0 0.851 1.000 1.000 577 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(3), CARS(2), DARS(1), EPRS(4), FARS2(1), GARS(1), HARS(1), IARS(5), LARS(1), LARS2(2), MARS(6), QARS(1), RARS(3), TARS(2), WARS(2), WARS2(1) 17773423 36 33 36 13 1 12 2 7 14 0 0.814 1.000 1.000 578 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT1(1), B3GAT2(1), B3GAT3(1), B4GALT7(1), CHPF(5), CHST11(2), CHST12(2), CHST13(3), CHST14(1), CHST3(5), CHST7(2), CHSY1(2), DSE(6), UST(3), XYLT1(3), XYLT2(1) 8256362 39 33 39 14 4 5 4 18 8 0 0.794 1.000 1.000 579 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAX(3), BCL2(1), CASP8(1), FADD(1), MAP2K4(4), MAP3K1(3), MAPK1(3), MAPK8(1), NFKB1(3), NSMAF(3), RAF1(2), RELA(4), RIPK1(4), SMPD1(4), TNFRSF1A(1) 11557898 38 32 36 15 3 9 4 11 11 0 0.918 1.000 1.000 580 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 16 DNAJA3(1), IFNG(3), IFNGR1(3), IFNGR2(1), IKBKB(4), JAK2(4), NFKB1(3), NFKBIA(2), RELA(4), TNF(1), TNFRSF1A(1), TNFRSF1B(1), USH1C(2), WT1(6) 9498582 36 32 36 14 1 9 4 15 7 0 0.891 1.000 1.000 581 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(1), EXT2(4), EXTL1(2), EXTL3(2), GLCE(2), HS2ST1(3), HS3ST1(3), HS3ST2(1), HS3ST3A1(1), HS3ST5(4), HS6ST2(1), HS6ST3(1), NDST1(2), NDST2(2), NDST3(4), NDST4(6) 11948998 39 31 39 18 4 14 1 13 7 0 0.958 1.000 1.000 582 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(2), CD3G(1), CD4(1), CXCR3(3), IFNG(3), IL12A(6), IL12B(2), IL12RB1(3), IL12RB2(5), JAK2(4), STAT4(4), TYK2(1) 8440895 35 31 35 13 2 7 4 16 6 0 0.797 1.000 1.000 583 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 13 C1QA(3), C2(4), C3(10), C4A(2), C4B(1), C5(5), C6(1), C7(1), C8A(4), C9(2) 17475943 33 30 33 11 3 7 4 6 13 0 0.701 1.000 1.000 584 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(2), POLD1(4), POLE(4), POLG(5), POLL(1), POLQ(17) 9491775 33 30 33 12 3 7 4 11 8 0 0.807 1.000 1.000 585 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(4), CSF1R(1), EGF(6), EGFR(6), MET(2), PDGFRA(5), PRKCA(1), SH3GLB1(2), SH3KBP1(1), SRC(3) 10925246 31 29 30 11 1 7 4 9 10 0 0.841 1.000 1.000 586 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(2), ACHE(5), CHAT(4), DDC(2), GAD1(5), GAD2(1), HDC(4), MAOA(1), PAH(2), TH(1), TPH1(2) 8163571 29 28 29 12 4 3 4 11 7 0 0.760 1.000 1.000 587 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 DRD1(1), DRD2(4), GRM1(4), PLCB1(8), PPP1CA(2), PPP1R1B(1), PPP2CA(2), PPP3CA(3), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3) 9054449 33 28 33 11 4 9 3 12 5 0 0.646 1.000 1.000 588 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(2), ACP2(1), ACP5(1), ACPP(6), ACPT(1), ENPP1(1), ENPP3(4), FLAD1(2), LHPP(1), MTMR1(2), MTMR2(1), MTMR6(4), PHPT1(1), RFK(1), TYR(5) 8571573 33 28 33 12 1 7 5 14 6 0 0.848 1.000 1.000 589 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(6), EP300(11), LPL(1), NCOA1(5), NCOA2(5), PPARG(1), RXRA(2) 10256894 31 28 29 10 0 8 3 13 7 0 0.706 1.000 1.000 590 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 13 CHUK(8), DUSP1(1), IKBKAP(5), IKBKB(4), MAP3K1(3), NFKB1(3), NFKBIA(2), RELA(4), TNFAIP3(1), TRAF3(1), TRAF6(2) 10780405 34 27 34 11 0 10 5 12 7 0 0.762 1.000 1.000 591 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(1), CSF1(2), HLA-DRA(1), HLA-DRB1(1), IFNB1(2), IFNG(3), IL10(1), IL12A(6), IL12B(2), IL4(1), IL5(1), IL6(2), IL7(1), PDGFA(2), TGFB1(1), TGFB2(4), TGFB3(2), TNF(1) 7741068 34 27 34 11 1 7 3 19 4 0 0.719 1.000 1.000 592 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(4), ICAM1(1), ITGA4(5), ITGAL(5), ITGAM(6), ITGB2(8), SELE(1), SELP(1) 9136102 31 27 30 13 2 10 2 11 6 0 0.915 1.000 1.000 593 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(4), CD44(4), CSF1(2), IL1B(1), IL6R(3), SPN(3), TGFB1(1), TGFB2(4), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TNFRSF8(3), TNFSF8(1) 7982061 29 27 29 12 2 9 2 10 6 0 0.872 1.000 1.000 594 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACOX1(2), ACOX3(1), ELOVL2(1), ELOVL5(1), FASN(18), HADHA(3), PECR(3), SCD(2) 8718770 31 26 31 16 3 8 3 12 5 0 0.956 1.000 1.000 595 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(3), ANKRD1(4), ATF3(3), DUSP14(1), IFNG(3), IFRD1(2), IL18(2), IL1R1(4), JUND(1), MYOG(1), NR4A3(2), WDR1(3) 6255574 29 26 27 15 1 7 3 6 12 0 0.962 1.000 1.000 596 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOB(1), DERA(1), FBP1(1), FBP2(2), G6PD(1), GPI(1), H6PD(5), PFKL(1), PFKM(1), PFKP(2), PGLS(2), PGM1(1), PGM3(2), PRPS1(1), PRPS1L1(1), RBKS(1), TALDO1(1), TKT(1), TKTL1(1), TKTL2(3) 13758186 30 25 29 16 2 7 2 12 7 0 0.953 1.000 1.000 597 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), CYP2C9(3), DHRS1(1), DHRS3(1), DHRS7(1), ECHS1(2), EHHADH(10), ESCO1(2), ESCO2(3), HADHA(3), NAT6(1), PNPLA3(1), SH3GLB1(2) 17286606 38 25 38 11 1 10 5 17 5 0 0.382 1.000 1.000 598 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(2), ADSS(2), IMPDH1(1), MTHFD2(2), NME2(1), POLB(2), POLD1(4), POLG(5), RRM1(5), SRM(2) 7414094 26 25 25 10 3 8 1 7 7 0 0.754 1.000 1.000 599 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 12 ADCY1(5), ADRB2(3), GNAS(10), PLCE1(5), PRKACB(2), PRKACG(2), PRKAR1B(1), PRKAR2B(3), PTGER1(1) 8643494 32 25 29 10 6 9 3 10 4 0 0.626 1.000 1.000 600 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 20 AKT1(2), CASP9(1), CDC42(3), CHUK(8), NFKB1(3), PIK3R1(4), RAF1(2), RALA(2), RALBP1(1), RALGDS(1), RELA(4) 9858756 31 25 31 11 2 6 6 7 10 0 0.798 1.000 1.000 601 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(1), CYB5R3(1), GFPT1(1), GNE(2), GNPDA2(2), HEXA(3), HEXB(1), HK1(3), HK2(3), HK3(5), PGM3(2), UAP1(1) 9695540 25 24 25 13 1 5 4 7 8 0 0.866 1.000 1.000 602 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(2), BCAT2(1), IARS(5), IARS2(3), LARS(1), LARS2(2), PDHA1(1), PDHA2(3), PDHB(2), VARS(2), VARS2(1) 10450689 23 22 23 11 1 7 1 8 6 0 0.954 1.000 1.000 603 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 9 AKAP9(8), MAP2(6), PPP1CA(2), PPP2CA(2), PRKACB(2), PRKACG(2), PRKAR2B(3) 9417506 25 21 25 10 1 6 0 9 9 0 0.948 1.000 1.000 604 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(10), C5(5), C6(1), C7(1), C8A(4), C9(2) 7140154 23 21 23 10 2 6 2 3 10 0 0.857 1.000 1.000 605 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(2), BAIAP2(1), CASP3(3), CASP8(1), INS(1), INSR(4), ITCH(1), MAGI1(1), MAGI2(6), RERE(3), WWP1(3), WWP2(1) 13367140 27 21 27 13 1 4 6 9 6 1 0.951 1.000 1.000 606 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(4), ICAM1(1), ITGA4(5), ITGAL(5), ITGB2(8), SELE(1) 6871480 24 21 23 11 1 9 1 9 4 0 0.913 1.000 1.000 607 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(2), GALNT10(1), GALNT3(2), GALNT4(4), GALNT7(1), GALNT8(2), GALNT9(1), ST3GAL1(1), ST3GAL2(1), WBSCR17(7) 8309821 22 21 22 10 4 2 3 9 4 0 0.872 1.000 1.000 608 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA2(1), ACAT1(2), ACAT2(5), ECHS1(2), EHHADH(10), HADHA(3), HADHB(4), SDS(2) 4771563 29 20 29 10 0 7 5 12 5 0 0.628 1.000 1.000 609 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOB(1), FBP1(1), FBP2(2), G6PD(1), GPI(1), H6PD(5), PFKM(1), PFKP(2), PGLS(2), PGM1(1), PGM3(2), PRPS1(1), PRPS1L1(1), RBKS(1), TALDO1(1), TKT(1) 11379836 24 20 23 15 2 7 0 8 7 0 0.981 1.000 1.000 610 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(8), MAPK14(3), MAPK8(1), NFKB1(3), RELA(4), TNFSF13B(1), TRAF3(1), TRAF5(2), TRAF6(2) 8169182 25 20 25 10 1 6 5 6 7 0 0.875 1.000 1.000 611 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 11 CREBBP(6), DAXX(1), PAX3(4), PML(2), RARA(1), SIRT1(2), SP100(1), TNF(1), TNFRSF1A(1), TNFRSF1B(1) 9245884 20 19 20 10 0 6 1 8 5 0 0.958 1.000 1.000 612 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOB(1), FBP1(1), FBP2(2), GPT(1), GPT2(2), MDH1(1), ME1(1), ME3(1), PGK2(2), PKLR(3), TKT(1), TKTL1(1), TKTL2(3), TPI1(1) 11409570 21 18 20 14 2 4 2 12 1 0 0.980 1.000 1.000 613 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(1), FOSL2(3), IFNAR1(2), IFNAR2(1), IFNB1(2), MAPK8(1), NFKB1(3), RELA(4), TNFRSF11A(1), TNFSF11(1), TRAF6(2) 6163089 21 17 21 10 2 6 1 7 5 0 0.912 1.000 1.000 614 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOB(1), FBP1(1), FBP2(2), GPT(1), GPT2(2), MDH1(1), ME1(1), ME2(3), ME3(1), PKLR(3), TKT(1), TPI1(1) 10237912 18 16 18 12 2 6 1 8 1 0 0.970 1.000 1.000 615 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(2), CD3G(1), CD4(1) 1810563 4 3 4 3 0 3 0 1 0 0 0.926 1.000 1.000 616 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 842079 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000