E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.028 0.142 -9999.0 0.0 -0.506 22.0 22.0 KLHL20 -0.005 0.077 0.34 1.0 -0.267 8.0 9.0 CYFIP2 -0.01 0.146 -9999.0 0.0 -0.616 20.0 20.0 Rac1/GDP -0.002 0.098 -9999.0 0.0 -0.316 20.0 20.0 ENAH -0.02 0.128 -9999.0 0.0 -0.443 23.0 23.0 AP1M1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.006 0.071 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.029 0.056 -9999.0 0.0 -0.187 19.0 19.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.025 0.115 -9999.0 0.0 -0.363 27.0 27.0 RAPGEF1 -0.027 0.128 -9999.0 0.0 -0.448 22.0 22.0 CTNND1 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.027 0.151 -9999.0 0.0 -0.51 24.0 24.0 CRK -0.023 0.13 -9999.0 0.0 -0.484 22.0 22.0 E-cadherin/gamma catenin/alpha catenin 0.02 0.107 -9999.0 0.0 -0.398 22.0 22.0 alphaE/beta7 Integrin 0.03 0.064 0.247 6.0 -0.45 5.0 11.0 IQGAP1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.043 0.018 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.03 0.145 -9999.0 0.0 -0.513 22.0 22.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.01 0.05 -9999.0 0.0 -0.211 3.0 3.0 MLLT4 0.023 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.026 0.092 -9999.0 0.0 -0.353 19.0 19.0 PI3K -0.009 0.066 -9999.0 0.0 -0.274 3.0 3.0 ARF6 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.005 0.119 -9999.0 0.0 -0.46 22.0 22.0 TIAM1 -0.009 0.143 -9999.0 0.0 -0.6 20.0 20.0 E-cadherin(dimer)/Ca2+ 0.031 0.097 -9999.0 0.0 -0.345 22.0 22.0 AKT1 -0.003 0.042 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.022 0.048 -9999.0 0.0 -0.616 2.0 2.0 CDH1 -0.015 0.153 -9999.0 0.0 -0.616 22.0 22.0 RhoA/GDP -0.001 0.098 -9999.0 0.0 -0.316 21.0 21.0 actin cytoskeleton organization -0.002 0.058 0.289 1.0 -0.197 7.0 8.0 CDC42/GDP 0.0 0.097 -9999.0 0.0 -0.316 21.0 21.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.0 0.072 -9999.0 0.0 -0.282 22.0 22.0 ITGB7 0.017 0.075 -9999.0 0.0 -0.616 5.0 5.0 RAC1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.034 0.103 -9999.0 0.0 -0.365 22.0 22.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.018 0.093 -9999.0 0.0 -0.343 22.0 22.0 mol:GDP -0.017 0.107 -9999.0 0.0 -0.365 22.0 22.0 CDC42/GTP/IQGAP1 0.032 0.01 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.004 0.103 -9999.0 0.0 -0.324 21.0 21.0 RAC1/GTP/IQGAP1 0.034 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.038 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.004 0.062 0.266 2.0 -0.241 14.0 16.0 NME1 0.027 0.023 0.339 2.0 -9999.0 0.0 2.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.03 0.145 -9999.0 0.0 -0.498 24.0 24.0 regulation of cell-cell adhesion -0.0 0.06 -9999.0 0.0 -0.234 2.0 2.0 WASF2 -0.005 0.037 -9999.0 0.0 -0.128 2.0 2.0 Rap1/GTP 0.008 0.081 -9999.0 0.0 -0.296 2.0 2.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.033 0.113 -9999.0 0.0 -0.344 27.0 27.0 CCND1 -0.006 0.076 0.297 2.0 -0.304 14.0 16.0 VAV2 -0.029 0.171 -9999.0 0.0 -0.499 33.0 33.0 RAP1/GDP 0.008 0.087 -9999.0 0.0 -0.305 2.0 2.0 adherens junction assembly -0.029 0.141 -9999.0 0.0 -0.481 24.0 24.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.023 0.106 -9999.0 0.0 -0.333 27.0 27.0 E-cadherin/beta catenin -0.013 0.101 -9999.0 0.0 -0.412 22.0 22.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.03 0.147 -9999.0 0.0 -0.513 22.0 22.0 PIK3CA 0.024 0.034 -9999.0 0.0 -0.616 1.0 1.0 Rac1/GTP -0.035 0.124 0.488 1.0 -0.381 24.0 25.0 E-cadherin/beta catenin/alpha catenin 0.02 0.107 -9999.0 0.0 -0.397 22.0 22.0 ITGAE 0.027 0.041 0.339 6.0 -9999.0 0.0 6.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.028 0.154 -9999.0 0.0 -0.522 24.0 24.0