Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.007 0.126 0.453 22.0 -0.242 13.0 35.0 KIRREL -0.016 0.154 0.323 1.0 -0.619 22.0 23.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.007 0.126 0.243 13.0 -0.454 22.0 35.0 PLCG1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.022 0.01 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.027 0.103 0.286 2.0 -0.349 19.0 21.0 ChemicalAbstracts:57-88-5 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.006 0.086 -9999.0 0.0 -0.319 18.0 18.0 FYN 0.035 0.139 0.276 61.0 -0.329 21.0 82.0 mol:Ca2+ 0.029 0.106 0.275 4.0 -0.347 21.0 25.0 mol:DAG 0.03 0.107 0.28 4.0 -0.348 21.0 25.0 NPHS2 0.017 0.043 0.322 5.0 -9999.0 0.0 5.0 mol:IP3 0.03 0.107 0.28 4.0 -0.348 21.0 25.0 regulation of endocytosis 0.016 0.088 -9999.0 0.0 -0.307 21.0 21.0 Nephrin/NEPH1/podocin/Cholesterol 0.019 0.103 0.267 4.0 -0.34 22.0 26.0 establishment of cell polarity 0.007 0.126 0.242 13.0 -0.453 22.0 35.0 Nephrin/NEPH1/podocin/NCK1-2 0.041 0.11 -9999.0 0.0 -0.338 21.0 21.0 Nephrin/NEPH1/beta Arrestin2 0.018 0.09 -9999.0 0.0 -0.31 21.0 21.0 NPHS1 0.043 0.076 0.33 21.0 -9999.0 0.0 21.0 Nephrin/NEPH1/podocin 0.019 0.097 -9999.0 0.0 -0.33 21.0 21.0 TJP1 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.026 0.001 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.025 0.037 0.339 1.0 -0.616 1.0 2.0 heterophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.031 0.108 0.284 4.0 -0.35 21.0 25.0 CD2AP 0.024 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.031 0.104 0.284 4.0 -0.354 18.0 22.0 GRB2 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 0.06 0.155 0.306 65.0 -0.313 21.0 86.0 cytoskeleton organization 0.001 0.096 -9999.0 0.0 -0.368 17.0 17.0 Nephrin/NEPH1 0.009 0.093 0.215 4.0 -0.325 22.0 26.0 Nephrin/NEPH1/ZO-1 0.02 0.108 -9999.0 0.0 -0.376 21.0 21.0