Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.005 0.071 -9999.0 0.0 -0.274 22.0 22.0 epithelial cell differentiation 0.026 0.095 -9999.0 0.0 -0.342 22.0 22.0 CYFIP2 -0.01 0.146 -9999.0 0.0 -0.616 20.0 20.0 ENAH -0.015 0.083 0.309 3.0 -0.403 3.0 6.0 EGFR 0.01 0.1 -9999.0 0.0 -0.616 9.0 9.0 EPHA2 -0.009 0.139 -9999.0 0.0 -0.556 21.0 21.0 MYO6 -0.008 0.094 -9999.0 0.0 -0.358 22.0 22.0 CTNNB1 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.028 0.097 -9999.0 0.0 -0.398 17.0 17.0 AQP5 0.005 0.083 -9999.0 0.0 -9999.0 0.0 0.0 CTNND1 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.005 0.085 -9999.0 0.0 -0.325 22.0 22.0 regulation of calcium-dependent cell-cell adhesion 0.004 0.099 -9999.0 0.0 -0.326 23.0 23.0 EGF 0.093 0.134 0.339 83.0 -9999.0 0.0 83.0 NCKAP1 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.047 0.171 -9999.0 0.0 -0.564 29.0 29.0 cortical microtubule organization 0.026 0.095 -9999.0 0.0 -0.342 22.0 22.0 GO:0000145 -0.022 0.078 -9999.0 0.0 -0.311 22.0 22.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.031 0.097 -9999.0 0.0 -0.345 22.0 22.0 MLLT4 0.023 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.039 0.092 -9999.0 0.0 -0.349 26.0 26.0 ARF6 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.028 0.087 -9999.0 0.0 -0.365 12.0 12.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.01 0.077 -9999.0 0.0 -0.302 22.0 22.0 PVRL2 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.005 0.086 -9999.0 0.0 -0.33 22.0 22.0 ARF6/GTP 0.033 0.085 -9999.0 0.0 -0.342 12.0 12.0 CDH1 -0.015 0.153 -9999.0 0.0 -0.616 22.0 22.0 EGFR/EGFR/EGF/EGF 0.034 0.12 -9999.0 0.0 -0.372 21.0 21.0 RhoA/GDP 0.028 0.092 -9999.0 0.0 -0.327 22.0 22.0 actin cytoskeleton organization -0.025 0.086 -9999.0 0.0 -0.348 21.0 21.0 IGF-1R heterotetramer 0.015 0.1 0.338 4.0 -0.615 8.0 12.0 GIT1 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.015 0.1 0.339 4.0 -0.616 8.0 12.0 IGF1 -0.226 0.312 -9999.0 0.0 -0.611 144.0 144.0 DIAPH1 -0.006 0.173 -9999.0 0.0 -0.645 22.0 22.0 Wnt receptor signaling pathway -0.026 0.095 0.342 22.0 -9999.0 0.0 22.0 RHOA 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.039 0.092 -9999.0 0.0 -0.351 25.0 25.0 CTNNA1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.025 0.088 -9999.0 0.0 -0.356 21.0 21.0 EFNA1 0.014 0.059 -9999.0 0.0 -0.616 3.0 3.0 LPP -0.025 0.078 -9999.0 0.0 -0.317 22.0 22.0 Ephrin A1/EPHA2 -0.0 0.115 -9999.0 0.0 -0.379 26.0 26.0 SEC6/SEC8 -0.008 0.076 -9999.0 0.0 -0.308 22.0 22.0 MGAT3 0.004 0.101 -9999.0 0.0 -0.331 23.0 23.0 HGF/MET -0.166 0.206 -9999.0 0.0 -0.352 189.0 189.0 HGF -0.316 0.321 0.339 1.0 -0.616 194.0 195.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.005 0.072 -9999.0 0.0 -0.276 22.0 22.0 actin cable formation 0.031 0.114 0.341 7.0 -0.31 6.0 13.0 KIAA1543 -0.025 0.083 -9999.0 0.0 -0.316 25.0 25.0 KIFC3 -0.006 0.086 -9999.0 0.0 -0.33 22.0 22.0 NCK1 0.026 0.001 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.007 0.085 -9999.0 0.0 -0.33 22.0 22.0 NCK1/GIT1 0.038 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.026 0.095 -9999.0 0.0 -0.342 22.0 22.0 EXOC4 0.025 0.006 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.005 0.086 -9999.0 0.0 -0.33 22.0 22.0 PIP5K1C -0.005 0.086 -9999.0 0.0 -0.33 22.0 22.0 LIMA1 0.026 0.002 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.003 0.12 0.327 5.0 -0.422 7.0 12.0 adherens junction assembly -0.024 0.1 -9999.0 0.0 -0.43 6.0 6.0 IGF-1R heterotetramer/IGF1 -0.125 0.193 -9999.0 0.0 -0.338 155.0 155.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.034 0.013 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.023 0.034 -9999.0 0.0 -0.616 1.0 1.0 PLEKHA7 -0.008 0.091 -9999.0 0.0 -0.331 25.0 25.0 mol:GTP 0.027 0.086 -9999.0 0.0 -0.363 12.0 12.0 establishment of epithelial cell apical/basal polarity -0.006 0.099 0.326 6.0 -9999.0 0.0 6.0 cortical actin cytoskeleton stabilization 0.005 0.071 -9999.0 0.0 -0.274 22.0 22.0 regulation of cell-cell adhesion -0.025 0.086 -9999.0 0.0 -0.348 21.0 21.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.005 0.072 -9999.0 0.0 -0.276 22.0 22.0