Hybridization REF p difference q subclass Composite Element REF p difference q subclass CAV1|CAVEOLIN-1 5.94852763276598e-15 1.05193309625536 1.32652166210681e-13 1 NKX2-1|TTF1 2.87824193044639e-10 1.04273284863622 2.46864596342133e-09 1 MYH11|MYH11 5.01670470642675e-08 0.914024876051601 2.38026627560248e-07 1 VHL|VHL 5.3465005713463e-06 0.730138394420526 1.65593003806976e-05 1 CTNNB1|BETA-CATENIN 9.10717660443178e-16 0.696970902976344 2.90128626112612e-14 1 TUBA1B|ACETYL-A-TUBULIN-LYS40 8.02261438209196e-09 0.617167491401873 4.25962620763454e-08 1 PRKCB|PKC-PAN_BETAII_PS660 6.41711916313873e-17 0.593005195463908 3.57754393344984e-15 1 RICTOR|RICTOR 1.25024696787787e-12 0.579423409593411 1.74253171147978e-11 1 PDCD4|PDCD4 1.48694632931822e-10 0.498392631367996 1.32635612575185e-09 1 GSK3A GSK3B|GSK3_PS9 7.12476623190213e-12 0.472445426960978 9.34601688067162e-11 1 AKT1 AKT2 AKT3|AKT_PS473 2.28758818735509e-11 0.466167504845054 2.58068550317944e-10 1 EGFR|EGFR_PY1068 2.10751558940601e-07 0.45949743249078 8.70325882291741e-07 1 CDH1|E-CADHERIN 2.51610790540151e-08 0.450993096770941 1.2197653541403e-07 1 NAPSA|NAPSIN-A 3.60404330040044e-06 0.446749733610448 1.16478500868014e-05 1 GSK3A GSK3B|GSK3-ALPHA-BETA_PS21_S9 1.3651707616533e-11 0.435528065937679 1.69129488804826e-10 1 ERBB2|HER2 5.22945213830529e-09 0.432882936324114 2.84431177278556e-08 1 TP63|P63 0.00402474951639937 0.390612830776237 0.00794264727572619 1 MAPK14|P38_PT180_Y182 2.78629926063325e-09 0.386853492845626 1.59319162851594e-08 1 TSC1|TSC1 2.28640143259553e-09 0.375654418635006 1.34175663018106e-08 1 SRC|SRC_PY527 1.23955038452402e-07 0.375138284236921 5.52839471497713e-07 1 AKT1 AKT2 AKT3|AKT 1.41813338542451e-08 0.366915933669883 7.18735783976513e-08 1 PARP1|PARP_CLEAVED 0.00616674808205185 0.349268717336478 0.011272006740144 1 MAPK1 MAPK3|MAPK_PT202_Y204 4.21502913698347e-06 0.334069701461621 1.32387534865819e-05 1 ERBB3|HER3 1.206020453753e-09 0.319261617375715 7.68407317676911e-09 1 BRAF|B-RAF 2.85546020337326e-06 0.309525338765938 9.50399440824234e-06 1 MET|C-MET 0.00495391644106297 0.307069612741567 0.00944208005433369 1 STAT3|STAT3_PY705 5.58784328194384e-10 0.303231480028731 3.89402828710461e-09 1 TSC2|TUBERIN 9.31161512592358e-08 0.297896772470555 4.237735047104e-07 1 RPS6|S6_PS235_S236 0.000196826484777762 0.29707676302337 0.000498776205743647 1 RPS6KA1|P90RSK 1.44794865019024e-10 0.291546112300958 1.32635612575185e-09 1 YAP1|YAP_PS127 1.88820730385287e-05 0.291288041790523 5.46844452934013e-05 1 MTOR|MTOR_PS2448 1.83718391875707e-17 0.291204391843696 2.04846006941413e-15 1 PXN|PAXILLIN 3.8176016272938e-06 0.289160106590695 1.2161788041236e-05 1 SNAI1|SNAIL 0.0164485707690084 0.287493728953402 0.0282156252422221 1 PRKCA |PKC-ALPHA_PS657 1.88523931899379e-07 0.287334607431461 7.93223336104934e-07 1 TGM2|TRANSGLUTAMINASE 3.34837873779267e-06 0.280324158094554 1.09807126254083e-05 1 STAT5A|STAT5-ALPHA 0.000301265896349452 0.272706374357776 0.000746469943176976 1 PTEN|PTEN 6.98733596912839e-10 0.272677422258791 4.72174521550191e-09 1 PRKAA1|AMPK_PT172 3.14854546591144e-05 0.26893489753016 8.77657048622814e-05 1 NFKB1|NF-KB-P65_PS536 0.000792118253739777 0.263058981474914 0.00178441606060993 1 ATM|ATM 0.00302308953544503 0.25838531834534 0.00607341411174992 1 MTOR|MTOR 3.69911101483461e-10 0.252252786501286 2.84448881485558e-09 1 MAPK1|ERK2 3.9773524807827e-05 0.246000045849342 0.000108164585757871 1 RPS6|S6_PS240_S244 0.0113325633326544 0.244041518130432 0.0198989104187554 1 PRKCA |PKC-ALPHA 5.11747510336297e-07 0.239081528972985 1.93423211533889e-06 1 EEF2K|EEF2K 2.56617053067131e-06 0.238594900297027 8.67054588393488e-06 1 CASP8|CASPASE-8 0.00502238832866123 0.23166374296791 0.00949146268891063 1 RET|RET_PY905 1.99082908518563e-06 0.23098969688727 6.93679509369368e-06 1 CLDN7|CLAUDIN-7 0.0428489290811836 0.220211045619783 0.0663563276743329 1 TSC2|TUBERIN_PT1462 5.09482583921413e-10 0.213230793103988 3.66498761982178e-09 1 MYH9|MYOSIN-IIA_PS1943 0.00573398583477237 0.210847831856775 0.0105675937285474 1 KDR|VEGFR2 0.00183166802951694 0.204283348207476 0.00392751894790652 1 ACACA ACACB|ACC_PS79 0.00300991089111463 0.193988375814251 0.00607341411174992 1 RBM15|RBM15 0.00222547389205872 0.193506590887436 0.00468189318801033 1 PDK1|PDK1_PS241 2.27897446168529e-08 0.192194516540809 1.12935845545738e-07 1 RAB25|RAB25 0.00334667026767146 0.1875243604256 0.00666345955081014 1 ERBB2|HER2_PY1248 0.00172707781018444 0.181367612977559 0.00373920729777796 1 MAPK9|JNK2 3.86014501385115e-10 0.175498764806961 2.86937446029602e-09 1 AKT1 AKT2 AKT3|AKT_PT308 6.04349760295203e-05 0.16757918975536 0.000160440472078369 1 BAD|BAD_PS112 3.22020395793367e-07 0.163279094825472 1.2598341800337e-06 1 SRC|SRC_PY416 0.0096356325115413 0.162182147951115 0.0170535400799501 1 RB1|RB 0.0092188905489558 0.16128597167217 0.0164465007393371 1 RPS6KA1|P90RSK_PT359_S363 7.04176635012272e-07 0.152593634033305 2.58382925724112e-06 1 KEAP1|KEAP1 0.0484195856338803 0.151119201331637 0.0724668966198343 1 JUN|C-JUN_PS73 2.60190648566289e-07 0.151011025297241 1.03611633268362e-06 1 PIK3R1 PIK3R2|PI3K-P85 0.000114316374988918 0.145418605061321 0.00029991237202975 1 XRCC5|KU80 0.00222547064401794 0.13918874555689 0.00468189318801033 1 GAB2|GAB2 0.0233805218220631 0.136109241664237 0.0389093758680602 1 KRT5|CK5 0.0349784439031204 0.13171922135024 0.0553205176623819 1 SHC1|SHC_PY317 8.15444294036188e-06 0.119662482506504 2.49101476123383e-05 1 TP53BP1|53BP1 0.0363430348347337 0.114669577307604 0.0570739209024339 1 AKT1S1|PRAS40_PT246 3.77240394208941e-07 0.10806286943532 1.4504242742861e-06 1 PRKCD|PKC-DELTA_PS664 2.03330204963261e-05 0.0946430163108205 5.81315842394964e-05 1 NF2|NF2 0.0324360829181251 0.0881068973714265 0.0524148296430572 1 PARK7|DJ-1 0.0336430883602107 0.0800075889073042 0.0535886336023356 1 RAD50|RAD50 0.00752652047236552 0.0759960233916524 0.013645642807622 1 PRKAA1|AMPK_ALPHA 0.047073367845501 0.0569122393437679 0.0709281150645049 1 CTNNA1|ALPHA-CATENIN 0.020638518234039 0.0565762052029356 0.0348665876226568 1 NRAS|N-RAS 0.0139560429849055 -0.0427564527285592 0.0241255626793328 1 CDK1|CDK1 0.0467325320770795 -0.0441682092429245 0.0708935690693111 1 RAF1|C-RAF_PS338 0.0232374936309982 -0.0464644894241709 0.0389093758680602 1 NOTCH1|NOTCH1 0.0465392959810581 -0.051057812405303 0.0708935690693111 1 FOXO3|FOXO3A 0.00867982503147847 -0.0531236782138365 0.0156096853388685 1 STK11|LKB1 0.0138998840719352 -0.0570023687281304 0.0241255626793328 1 YWHAB|14-3-3_BETA 0.0269041116085209 -0.0571380891164951 0.0441148300639718 1 CHEK1|CHK1_PS345 0.000825536575324041 -0.0576043718704259 0.0018260476632393 1 PREX1|PREX1 0.0490989164953904 -0.0595270454472556 0.0729937225231471 1 YWHAE|14-3-3_EPSILON 0.00259896755808557 -0.0612031517543597 0.00531715381149617 1 EIF4E|EIF4E 0.00545773900893134 -0.0646245186643796 0.0101422983249307 1 DVL3|DVL3 0.025815189909315 -0.0675107769022298 0.0426428692576092 1 EEF2|EEF2 0.0463922482107984 -0.068804241042024 0.0708935690693111 1 IRS1|IRS1 0.00248542268739163 -0.0714326319401086 0.00513193758600309 1 SMAD1|SMAD1 0.000709468823497535 -0.0755252354408233 0.00164830216747348 1 MYC|C-MYC 0.0402908471484391 -0.0793772690458119 0.0628311812174959 1 BAK1|BAK 4.41525320647638e-05 -0.0804244528003145 0.00011862668253545 1 ADAR|ADAR1 0.00443080777594811 -0.0870358228716856 0.00866728187751253 1 BID|BID 0.000177352812288053 -0.0879610852837335 0.000454593990117653 1 ERBB3|HER3_PY1289 1.27352615181744e-06 -0.0902149196837479 4.58058599766595e-06 1 ETS1|ETS-1 0.000578277751426167 -0.0917105497628645 0.00137187168689399 1 MET|C-MET_PY1235 1.90435577726799e-06 -0.0957311196182104 6.74081489413908e-06 1 CDKN1B|P27_PT157 0.000709582995863022 -0.101306879789666 0.00164830216747348 1 BRCA2|BRCA2 0.000412103537388756 -0.105996173670937 0.000998903139540137 1 XRCC1|XRCC1 0.000122361219781364 -0.106559333728273 0.000317285488502839 1 EZH2|EZH2 0.000327802804295133 -0.107226413127355 0.000803296981954007 1 PEA15|PEA15 0.00488838642195714 -0.111313957490638 0.00939750148359002 1 EIF4EBP1|4E-BP1_PS65 9.10053461888804e-06 -0.113549308689251 2.74245840542167e-05 1 TIGAR|TIGAR 0.00460361278785715 -0.113766549086192 0.00892700566688821 1 SMAD3|SMAD3 4.37497205873758e-09 -0.114720847853202 2.4390469227462e-08 1 CASP9|CASPASE-9 3.30123842337388e-05 -0.124325161238271 9.08859467175772e-05 1 ERRFI1|MIG-6 0.000229924252165 -0.131353440561535 0.000576102339694326 1 MRE11A|MRE11 9.19186079661894e-09 -0.131379314619997 4.7669417619675e-08 1 BAX|BAX 0.00106788826202616 -0.13583432855446 0.0023346968865866 1 SYK|SYK 0.0173452745514545 -0.14087569211721 0.0295266887402622 1 CCND1|CYCLIN_D1 2.38161740767513e-07 -0.158387779214694 9.65637603475553e-07 1 CDKN1B|P27_PT198 1.61010926309645e-09 -0.158576304373142 9.70417204514888e-09 1 PDCD1|PDCD1 0.0331127638724382 -0.164201737023927 0.0531233549895951 1 CHEK2|CHK2 0.000762205915566727 -0.166954682162521 0.00175228782650907 1 NFE2L2|NRF2 1.73634701234702e-07 -0.172534294313034 7.4462573798728e-07 1 CDKN2A|P16_INK4A 0.005159609668066 -0.17271022698672 0.00966884836956906 1 WWTR1|TAZ 1.60596043405151e-09 -0.177073234037093 9.70417204514888e-09 1 PARP1|PARP1 0.0274902162771362 -0.177938031723201 0.0447468483927107 1 CDH2|N-CADHERIN 1.40411549477793e-10 -0.186511329777802 1.32635612575185e-09 1 CCNE2|CYCLIN_E2 8.54923801219168e-15 -0.18831307512986 1.73316370610795e-13 1 CHEK2|CHK2_PT68 3.67007275171681e-13 -0.200946021956761 5.45617482421899e-12 1 TYMS|THYMIDILATE-SYNTHASE 7.59217806010405e-08 -0.209233371488885 3.52719939042334e-07 1 PCNA|PCNA 2.42244935804235e-11 -0.213329441034091 2.58068550317944e-10 1 PRDX1|PRDX1 9.37011887020135e-06 -0.220056022743854 2.78604867740653e-05 1 RAD51|RAD51 2.43024195366674e-11 -0.22682587464737 2.58068550317944e-10 1 CASP3|CASPASE-3 1.62164360427297e-07 -0.228825249114368 7.0907161520171e-07 1 CDKN1A|P21 0.000827044008911073 -0.233319421841767 0.0018260476632393 1 MSH6|MSH6 1.33687934700643e-05 -0.238505879559034 3.92268545240045e-05 1 STMN1|STATHMIN 2.92240736381093e-15 -0.245752732291452 7.24107602366486e-14 1 G6PD|G6PD 0.000792184708521899 -0.300812404349414 0.00178441606060993 1 CCNE1|CYCLIN_E1 3.43296418976498e-10 -0.30165153453552 2.78867058340883e-09 1 EIF4EBP1|4E-BP1_PT70 1.29086853136766e-21 -0.306900174868782 2.87863682494988e-19 1 CHEK1|CHK1 2.93585293170311e-14 -0.3105560514504 5.45579336474828e-13 1 YWHAZ|14-3-3_ZETA 2.04173390220286e-06 -0.328510155262436 7.00471784909597e-06 1 BCL2L11|BIM 4.43627175298904e-11 -0.33826414559191 4.49676636780253e-10 1 GAPDH|GAPDH 0.000565650180723381 -0.348497950061178 0.00135634398173456 1 FOXM1|FOXM1 3.00207370009585e-17 -0.388325116575758 2.23154145040458e-15 1 HSPA1A|HSP70 2.30400424584757e-05 -0.405481963921098 6.50370818764567e-05 1 EIF4EBP1|4E-BP1 1.98355924123675e-16 -0.44019906337207 7.37222851326325e-15 1 FN1|FIBRONECTIN 1.00952086974959e-09 -0.574056610598914 6.62126923394584e-09 1 LCN2|LCN2A 0.00230840331367996 -0.582253931998537 0.00481097139206197 1 CASP7|CASPASE-7_CLEAVEDD198 1.20134600113166e-13 -0.587216154173885 1.91357255894543e-12 1 TFRC|TFRC 3.50146979082723e-10 -0.630859215248928 2.78867058340883e-09 1 ASNS|ASNS 5.96485348855642e-14 -0.635353166693539 1.02320179072929e-12 1 CD274|CD274 7.06787375299141e-07 -0.682376121690008 2.58382925724112e-06 1 CCNB1|CYCLIN_B1 2.2662114499493e-15 -0.695201399319182 6.31706441673367e-14 1 SERPINE1|PAI-1 8.9737969255376e-17 -1.00011044742003 4.00231342878977e-15 1 CCNB1|CYCLIN_B1 1.24097157884639e-23 0.973176893273394 2.76736662082745e-21 2 GAPDH|GAPDH 1.1591452302141e-20 0.970741649396341 1.29244693168872e-18 2 TFRC|TFRC 1.91878854282999e-13 0.848388914700778 7.13149741751813e-12 2 ASNS|ASNS 3.94608606121301e-12 0.697807342661104 6.28555136893215e-11 2 CD274|CD274 0.000109283743258956 0.625359115457022 0.000374927303796111 2 SERPINE1|PAI-1 9.18602369842495e-06 0.622091108579105 4.09696656949753e-05 2 MSH6|MSH6 1.17978088114133e-17 0.554341088853404 8.76970454981722e-16 2 G6PD|G6PD 8.72464613707568e-06 0.485417414233261 4.09563592980821e-05 2 EIF4G1|EIF4G 8.92358488440084e-07 0.482817844022492 5.10246007492663e-06 2 CASP7|CASPASE-7_CLEAVEDD198 4.94616370764894e-07 0.457154840114852 3.15141287658775e-06 2 VHL|VHL 0.00785673828663649 0.454566923351517 0.0166862155992375 2 FN1|FIBRONECTIN 2.28462213091314e-05 0.449933737215923 9.09769169988625e-05 2 FOXM1|FOXM1 2.31539331937701e-13 0.415903806987927 7.37618157458676e-12 2 MSH2|MSH2 2.98398894061897e-13 0.393671100557738 8.31786917197538e-12 2 EIF4EBP1|4E-BP1 2.56863120433577e-10 0.379743244480482 2.86402379283438e-09 2 CCNE1|CYCLIN_E1 9.97416932668488e-10 0.343827527903735 9.6706076515249e-09 2 ATM|ATM 0.000117995497949289 0.336460942887366 0.000386955824157227 2 TP53BP1|53BP1 2.54396840461933e-08 0.308220637461665 2.18194213165427e-07 2 BCL2L11|BIM 4.54175582586994e-07 0.307939206936066 3.06912590657272e-06 2 MYH9|MYOSIN-IIA_PS1943 0.000111381388445309 0.290173903997106 0.000376334085201574 2 ACACA|ACC1 0.000354341316977607 0.286875206683236 0.00108243991350694 2 EEF2|EEF2 2.26980337943112e-17 0.283230660928264 1.26541538403285e-15 2 CHEK2|CHK2 7.89825913962975e-08 0.280665052703939 6.07348892461184e-07 2 BRAF|B-RAF 2.88184130722393e-05 0.27721905926656 0.000111691286471151 2 PCNA|PCNA 6.51058079158276e-13 0.274593056105418 1.61317724058106e-11 2 RPS6KB1|P70S6K 3.31020348605318e-12 0.271429825427601 6.15146147824883e-11 2 STAT5A|STAT5-ALPHA 0.000901166107644934 0.26695176835269 0.00233674467447465 2 TP53|P53 0.000105395535240815 0.25610626281679 0.000367237568104715 2 FASN|FASN 0.00201172975213842 0.255924524014189 0.0048762579861616 2 RBM15|RBM15 8.44430305589333e-05 0.248680710655444 0.000308701570731838 2 RPS6|S6 9.40457896780779e-07 0.248630857408223 5.24305277455284e-06 2 INPP4B|INPP4B 0.0101735141543906 0.226275165919187 0.0207570942162556 2 XRCC5|KU80 1.76410815558459e-06 0.222323748900829 9.59502728525277e-06 2 TSC1|TSC1 0.000475170790510525 0.217285223579309 0.0013761439777123 2 RPTOR|RAPTOR 5.61538623982556e-07 0.215592925253965 3.47841980966972e-06 2 SYK|SYK 0.00135120090585974 0.215576864707968 0.00331118463743651 2 ERRFI1|MIG-6 4.94515805590526e-07 0.212324826730813 3.15141287658775e-06 2 CDH3|P-CADHERIN 2.51011175258249e-07 0.20712843628395 1.80566103492224e-06 2 GAB2|GAB2 0.00411632361703176 0.198275616301492 0.00956187673539669 2 GSK3A GSK3B|GSK3-ALPHA-BETA 1.69758981978606e-10 0.192658827908529 2.10312516562384e-09 2 MAPK1|ERK2 0.00119058169932378 0.189434712170232 0.0030170422607864 2 TSC2|TUBERIN 0.000769737985885598 0.183581207338106 0.00206809121509022 2 BAP1|BAP1-C-4 8.51572517174656e-08 0.182362053291242 6.33002237766494e-07 2 PARP1|PARP1 0.035595813505389 0.175082144453255 0.0583666647919246 2 AKT1 AKT2 AKT3|AKT 0.010238925398153 0.170300455921481 0.0207570942162556 2 EIF4EBP1|4E-BP1_PT70 4.79869151695154e-06 0.163652078831221 2.47867621515572e-05 2 DVL3|DVL3 8.81571859330915e-06 0.138585186561053 4.09563592980821e-05 2 RAD50|RAD50 1.11126135815095e-05 0.122799086117249 4.85904476211102e-05 2 LCK|LCK 0.0196448318670944 0.113164041448865 0.0356162398891224 2 ARID1A|ARID1A 0.0012277068853339 0.109824799993584 0.00307616444302764 2 EIF4EBP1|4E-BP1_PS65 0.000462712419615681 0.106312606484051 0.00135769565229338 2 ADAR|ADAR1 0.000853577639018363 0.10426776715143 0.00223938604118935 2 TYMS|THYMIDILATE-SYNTHASE 0.0475380389532361 0.0995956350780872 0.074654807651913 2 TIGAR|TIGAR 0.0454514586787943 0.0908960391142912 0.0723976806097938 2 CDKN1B|P27_PT198 0.00645786672707187 0.0851423691244391 0.0142584582191785 2 PREX1|PREX1 0.0130497656084738 0.0849695166407063 0.0248726301768347 2 AXL|AXL 0.0252127022641525 0.0836670751855932 0.0439252547258282 2 SRC|SRC 0.0281595694708334 0.0832399487006247 0.0475726059999685 2 CCNE2|CYCLIN_E2 0.0043095641672864 0.0717965645122004 0.00980645723780477 2 XRCC1|XRCC1 0.0130319438499651 0.0714775496970551 0.0248726301768347 2 PIK3CA |PI3K-P110-ALPHA 0.00475989165552953 0.0687260143258669 0.0107217761533645 2 BIRC2 |CIAP 0.0115080046351233 0.0608940811909357 0.0225112722248465 2 BID|BID 0.0138675993125541 0.0589361344968001 0.0259871819050384 2 BAK1|BAK 0.00429228953541388 0.0579951180996558 0.00980645723780477 2 RAF1|C-RAF 0.014903791605435 0.0568735650498343 0.0274093081864381 2 EIF4E|EIF4E 0.025739137996278 0.0561877672189827 0.0444947889393023 2 SMAD1|SMAD1 0.0422681985509782 0.0521467232552397 0.0678115703371809 2 CHEK1|CHK1_PS345 0.0382293381622398 0.0400160400186257 0.0622273168626239 2 ERBB3|HER3_PY1289 0.00778458062096699 -0.048583987620895 0.0166862155992375 2 CDKN1B|P27_PT157 0.0485788211098254 -0.0525785850049847 0.075755783968469 2 SMAD4|SMAD4 0.00748801673602655 -0.053579979548075 0.0162119197294555 2 EGFR|EGFR_PY1173 0.0302462918128749 -0.0551090436504717 0.0507137073253466 2 PRKCD|PKC-DELTA_PS664 0.0109074464702053 -0.0572064817405278 0.0217175050254981 2 NRG1|HEREGULIN 0.0244675219786597 -0.0579941125072284 0.0429626567026859 2 CHGA|CHROMOGRANIN-A-N-TERM 0.0489240729589622 -0.063970050298184 0.0757643629850595 2 BRCA2|BRCA2 0.0266696366726384 -0.0655945336337772 0.0457486844461413 2 FOXO3|FOXO3A 0.000583083592519928 -0.0663530363928481 0.00160527952014746 2 CTNNA1|ALPHA-CATENIN 0.00378388341647194 -0.0683932393722015 0.00888216844077097 2 BCL2L1|BCL-XL 0.0198056489261721 -0.0705051838703085 0.0356182234720676 2 PGR|PR 0.011989772978119 -0.0725444109332356 0.0232497336880047 2 DIRAS3|ARHI 1.38912902368295e-05 -0.0821187292615885 5.84482589209996e-05 2 RPS6KB1|P70S6K_PT389 0.0149243056319585 -0.0827732517522055 0.0274093081864381 2 PTEN|PTEN 0.0469066311821659 -0.0912967139699516 0.074185664919312 2 SHC1|SHC_PY317 0.000493923981739106 -0.0979213496715324 0.00139424111301039 2 AR|AR 0.000761947885963708 -0.102322925877601 0.00206809121509022 2 PARP1|PARP-AB-3 0.0226036008751642 -0.108106298644189 0.0400047856758858 2 RAF1|C-RAF_PS338 4.22374756772922e-08 -0.108261383991471 3.48850262075413e-07 2 YBX1|YB-1_PS102 0.00644097093597862 -0.108296930298814 0.0142584582191785 2 CDKN1B|P27 0.000115811684653941 -0.11110903542681 0.000385462771310878 2 YWHAB|14-3-3_BETA 3.47194983688423e-06 -0.115133178470614 1.84344003244091e-05 2 FOXO3|FOXO3A_PS318_S321 6.57765982787113e-08 -0.116953396399834 5.23863622005451e-07 2 KRT5|CK5 0.0135510679818829 -0.11750222661247 0.0256092216945753 2 RAB11A RAB11B|RAB11 5.82793168323548e-06 -0.12444985320524 2.88806392302558e-05 2 ERCC1|ERCC1 0.00953883754243437 -0.127723362703761 0.0198800072146062 2 BAD|BAD_PS112 0.000155219196434519 -0.127993987275459 0.000501650446447793 2 JUN|C-JUN_PS73 1.48333158484159e-05 -0.130803236008401 6.12561006332731e-05 2 RPS6KA1|P90RSK_PT359_S363 7.65712195406821e-05 -0.130967305163526 0.000284589699292868 2 DIABLO|SMAC 0.032838596223051 -0.132362864323037 0.0546493056547789 2 AKT1S1|PRAS40_PT246 1.11896550766614e-08 -0.133846460201058 9.98117232838197e-08 2 PDK1|PDK1 1.19172955626448e-09 -0.137587454241446 1.10731537936241e-08 2 TGM2|TRANSGLUTAMINASE 0.0355246105849712 -0.13997157093451 0.0583666647919246 2 ACVRL1|ACVRL1 3.73000802636107e-07 -0.140223587342262 2.59934934337037e-06 2 ESR1|ER-ALPHA 0.0149952269002038 -0.141488878689737 0.0274093081864381 2 RPS6KA1|P90RSK 0.000950146847365136 -0.148031302847361 0.00243543387313133 2 TSC2|TUBERIN_PT1462 2.17908569928528e-05 -0.15724615697857 8.83520201710214e-05 2 RB1|RB 0.00210410276066119 -0.158979555367096 0.00504532167341339 2 RICTOR|RICTOR_PT1135 5.9104420742517e-11 -0.162847481281935 8.23767864098831e-10 2 MAPK8|JNK_PT183_PY185 2.00985504010757e-10 -0.171792053926963 2.35893512602099e-09 2 CASP8|CASPASE-8 0.0105061906946 -0.179757187807993 0.021107031755818 2 AKT1 AKT2 AKT3|AKT_PT308 9.03337457719755e-06 -0.193984895041446 4.09696656949753e-05 2 PRKCB|PKC-PAN_BETAII_PS660 0.00859458823522632 -0.197490005205699 0.0180810677024101 2 CDH1|E-CADHERIN 0.0211833790762302 -0.205837288624567 0.0377911482719947 2 YAP1|YAP 4.89066159044178e-06 -0.206917704778111 2.47867621515572e-05 2 RPS6|S6_PS240_S244 0.0412330241261422 -0.21165987074114 0.0666301766676066 2 STAT3|STAT3_PY705 4.56921890804108e-05 -0.215496202584587 0.000172700985846298 2 RET|RET_PY905 2.90497516382365e-05 -0.224588621680024 0.000111691286471151 2 ERBB3|HER3 1.23444018199781e-05 -0.231502874271583 5.29384924202907e-05 2 RICTOR|RICTOR 0.00348555082983629 -0.236875174824312 0.00826891313886694 2 COL6A1|COLLAGEN_VI 0.000189315924485199 -0.239285458082598 0.000603106445145705 2 ERBB2|HER2_PY1248 9.75438808790327e-05 -0.241629670930176 0.000345274372000386 2 MAP2K1|MEK1_PS217_S221 8.89616561984913e-11 -0.246494712416203 1.16696760778021e-09 2 MTOR|MTOR_PS2448 1.21244413533787e-11 -0.247374723086066 1.8025002812023e-10 2 EGFR|EGFR_PY1068 0.00720704371933609 -0.24740049560218 0.0157565759746269 2 PECAM1|CD31 1.76193129006569e-12 -0.251906661782802 3.62388483192514e-11 2 SRC|SRC_PY416 0.000215928798924095 -0.252786206364546 0.000678198903663003 2 CLDN7|CLAUDIN-7 0.0110159288574345 -0.281208932676122 0.0217393994266185 2 AKT1 AKT2 AKT3|AKT_PS473 9.14573050627206e-05 -0.29272900297347 0.000328951274661076 2 RPS6|S6_PS235_S236 0.000370133979127665 -0.302373774003353 0.00111540374791175 2 MET|C-MET 0.000518480916578691 -0.303407546151696 0.0014452655549631 2 NDRG1|NDRG1_PT346 0.00997307824296058 -0.304541295380558 0.0205925597053723 2 SNAI1|SNAIL 0.00131683925953981 -0.307564889095143 0.00326283505419308 2 KIT|C-KIT 0.000843306159505482 -0.338456406331247 0.00223877706630622 2 YAP1|YAP_PS127 8.04694742962e-06 -0.340911047596724 3.90102016696796e-05 2 PARP1|PARP_CLEAVED 0.000442849456618434 -0.357069602033389 0.00131673905101214 2 PDCD4|PDCD4 5.78136951993221e-07 -0.394423193938539 3.48444703498617e-06 2 SRC|SRC_PY527 6.98977570832812e-07 -0.395490539929207 4.10189469199255e-06 2 LCN2|LCN2A 0.0275664437986099 -0.438009592378087 0.0469260837182443 2 MAPK14|P38_PT180_Y182 3.32974267699938e-10 -0.473859966954806 3.53586960462315e-09 2 TP63|P63 0.000237722562995125 -0.505145592060412 0.000736279604832123 2 NAPSA|NAPSIN-A 3.92915508519385e-12 -0.537571071746126 6.28555136893215e-11 2 MAPK1 MAPK3|MAPK_PT202_Y204 8.09080133016685e-15 -0.553735686252715 3.60849739325442e-13 2 NKX2-1|TTF1 0.000483400052748813 -0.717395942853123 0.00138202835593571 2 CAV1|CAVEOLIN-1 1.78756650902137e-12 -0.96721561333706 3.62388483192514e-11 2 MYH11|MYH11 7.03991181091168e-10 -1.14459017536898 7.1359106083332e-09 2 LCN2|LCN2A 5.01986512410159e-07 1.42599694538485 2.18866119410829e-06 3 SERPINE1|PAI-1 0.000225970079419799 0.696932886571686 0.000594698033524809 3 YWHAZ|14-3-3_ZETA 4.89098821165952e-05 0.61596301868747 0.000138472133784646 3 HSPA1A|HSP70 0.000209607177659267 0.531146007347055 0.00056444713471659 3 COL6A1|COLLAGEN_VI 2.22577184732724e-09 0.529069800402192 1.31140071004686e-08 3 CHEK1|CHK1 3.982383027122e-09 0.513732299926173 2.28463026292788e-08 3 NDRG1|NDRG1_PT346 0.00471174344564571 0.408387512670386 0.00908991213407756 3 YAP1|YAP 1.30617973918527e-08 0.405236478416977 6.77969483672355e-08 3 MAP2K1|MEK1_PS217_S221 1.42260915164114e-11 0.371892931917413 1.72293775032094e-10 3 CASP3|CASPASE-3 0.000209725770238733 0.369537666295255 0.00056444713471659 3 PECAM1|CD31 1.35650777785013e-09 0.365529199675737 8.44910558775224e-09 3 CDH2|N-CADHERIN 4.09887636284955e-11 0.363908780728179 4.06161385046001e-10 3 STMN1|STATHMIN 8.44172123528948e-11 0.357317013256996 7.07805857420426e-10 3 BAX|BAX 7.56332928606738e-06 0.345561402006005 2.5762590380667e-05 3 RAD51|RAD51 8.60169563004817e-10 0.342173940021068 6.04893434629194e-09 3 KIT|C-KIT 0.000675964889295596 0.339718188748276 0.00153500360277542 3 WWTR1|TAZ 1.44970073251339e-08 0.335233077277648 7.34964557413765e-08 3 CHEK2|CHK2_PT68 6.51323859043336e-11 0.320851086336075 5.91619171964363e-10 3 CDKN2A|P16_INK4A 0.00149550674349857 0.317146237074249 0.0031652472823562 3 MAPK1 MAPK3|MAPK_PT202_Y204 0.0038144467421652 0.305002529977743 0.00769953138696309 3 PRDX1|PRDX1 0.000282546808479226 0.300162966457805 0.000724649461746721 3 MRE11A|MRE11 7.55883346529617e-11 0.28704897298789 6.59130278173826e-10 3 YWHAB|14-3-3_BETA 1.10825800493881e-09 0.274058652622939 7.10588956107825e-09 3 BCL2|BCL-2 0.00388495172586973 0.268565389459549 0.00776990345173946 3 CASP7|CASPASE-7_CLEAVEDD198 0.0156692491554973 0.266345824413291 0.0268968213850269 3 MAPK8|JNK_PT183_PY185 2.04544764429644e-12 0.264244627365526 3.43005835735865e-11 3 EIF4EBP1|4E-BP1_PT70 7.70239846275977e-07 0.256223529749941 3.22908243246467e-06 3 ACVRL1|ACVRL1 1.74984311706463e-09 0.250781869859264 1.05962722088914e-08 3 CDKN1B|P27_PT157 0.00111456786360361 0.250300843901479 0.00242975794265587 3 RAF1|C-RAF_PS338 4.35379905945043e-14 0.245616176003429 1.58188032493366e-12 3 BRCA2|BRCA2 1.08364070275029e-06 0.240212401556413 4.29515769453751e-06 3 NFE2L2|NRF2 2.56746843079935e-05 0.23195456359922 7.66723449197614e-05 3 ERBB3|HER3_PY1289 4.7696694397506e-11 0.225635225270989 4.52081712115492e-10 3 CDKN1A|P21 0.0165898569343658 0.208233652276895 0.0282546000913418 3 PEA15|PEA15 0.00680549472505305 0.203360093997562 0.012572863136115 3 CCNE2|CYCLIN_E2 3.43389933528576e-05 0.201711129755926 0.000101160818255716 3 RICTOR|RICTOR_PT1135 5.21822927170463e-06 0.20011755665897 1.83479674392195e-05 3 CASP9|CASPASE-9 7.17924616286969e-05 0.198405740170317 0.000200650726090461 3 PDK1|PDK1 1.07152737999007e-06 0.198277024939769 4.29515769453751e-06 3 PARP1|PARP-AB-3 0.00673958513023138 0.192445742227227 0.0125575175930807 3 FOXO3|FOXO3A 4.0015929101555e-08 0.191544537974929 1.89640707481282e-07 3 CCND1|CYCLIN_D1 0.000647268152596986 0.181088854761594 0.00148531007648572 3 FOXO3|FOXO3A_PS318_S321 6.12203933765843e-06 0.165412007216169 2.11841996128498e-05 3 TYMS|THYMIDILATE-SYNTHASE 0.00144184728202886 0.160221947962585 0.00308159517139501 3 DIABLO|SMAC 0.0461152169842365 0.155527253258661 0.0744675355745449 3 SMAD3|SMAD3 3.61594334618773e-06 0.154454478847372 1.29225516306381e-05 3 MET|C-MET_PY1235 4.87182468026863e-05 0.152768553540015 0.000138472133784646 3 DIRAS3|ARHI 8.510199903722e-06 0.149306337031929 2.85419012155599e-05 3 NRG1|HEREGULIN 0.00442855543368061 0.144524011482737 0.00861986682627119 3 RPS6KB1|P70S6K_PT389 0.000422219259248284 0.144096062123533 0.00105525361676576 3 YWHAE|14-3-3_EPSILON 3.33024313540627e-06 0.141876772357242 1.20998833919761e-05 3 CDKN1B|P27 0.00104098084423274 0.140541107631818 0.00229226084891654 3 SMAD4|SMAD4 8.69668753604145e-06 0.135251663513061 2.87254224675309e-05 3 RAB11A RAB11B|RAB11 0.00125801148224038 0.132761337066652 0.0027153119121624 3 BCL2L1|BCL-XL 0.00293676398971187 0.132195158384315 0.00598331354913259 3 CDKN1B|P27_PT198 0.000784206432255912 0.131485461998831 0.0017624433219772 3 ESR1|ER-ALPHA 0.0329098511386011 0.128952355785932 0.0543511177895079 3 YBX1|YB-1_PS102 0.00975407592733116 0.127636354284902 0.0175734591087454 3 EZH2|EZH2 0.00235008846064219 0.122936488669404 0.00483320079641507 3 EGFR|EGFR_PY1173 0.000438314721327987 0.116102488309121 0.0010736248230281 3 MS4A1|CD20 0.00420995605957652 0.111534561222075 0.00834336746352438 3 ETS1|ETS-1 0.00428966749639406 0.107184689588453 0.00842475238030545 3 NRAS|N-RAS 0.000449517586297681 0.102574750789579 0.00108883148680994 3 CDK1|CDK1 0.00663811554934144 0.0870986882316672 0.0124750792220382 3 AR|AR 0.0457547162594072 0.0795950809531671 0.0744367771981401 3 PCNA|PCNA 0.0492328669399035 -0.071936857602961 0.0789173896536689 3 TSC2|TUBERIN_PT1462 0.0144839669637341 -0.110329058769363 0.0250595618896352 3 ERRFI1|MIG-6 0.00609891762790223 -0.111530350537954 0.0115614264598494 3 PIK3CA |PI3K-P110-ALPHA 0.000226421728360363 -0.115244908686162 0.000594698033524809 3 BIRC2 |CIAP 3.10654032000823e-06 -0.136012768275983 1.14784032163016e-05 3 AXL|AXL 0.000425973937043058 -0.13672312310063 0.00105525361676576 3 CHEK2|CHK2 0.0112939364042327 -0.158537879681088 0.0201809683288748 3 KEAP1|KEAP1 0.0386527914114112 -0.159369113280322 0.0633557032156966 3 EGFR|EGFR 0.00173988868028131 -0.167715624354745 0.00364707434905121 3 STAT3|STAT3_PY705 0.0199762418201465 -0.169521307290253 0.0334986208983995 3 ERBB3|HER3 0.0130744992800389 -0.171308978992845 0.0228019267443878 3 LCK|LCK 0.0058004715080501 -0.171371241303135 0.0110921297259204 3 ARID1A|ARID1A 2.24528228396735e-05 -0.175172145909159 6.79821580423448e-05 3 YBX1|YB-1 0.019349434624185 -0.201102670230557 0.0326990445587002 3 MAPK9|JNK2 2.23703970933393e-05 -0.211782366325333 6.79821580423448e-05 3 NF2|NF2 0.00029637624586249 -0.223403587671298 0.000751279320907242 3 RPS6|S6 0.00840735759715228 -0.247348287719459 0.0154017139174722 3 TGM2|TRANSGLUTAMINASE 0.000539141520967794 -0.248818846049053 0.00126379410291375 3 BAP1|BAP1-C-4 0.000244571261870317 -0.249330674475523 0.000634720655806299 3 G6PD|G6PD 0.00875977095235932 -0.254129122453524 0.0159135838967861 3 RPS6KA1|P90RSK 1.96563011190332e-05 -0.254960833687629 6.12153377707034e-05 3 INPP4B|INPP4B 0.0127110491858777 -0.267679146002953 0.0223468445364624 3 PDK1|PDK1_PS241 2.74885294477904e-06 -0.282245385618737 1.0331895551066e-05 3 PTEN|PTEN 1.64723376070164e-05 -0.311766701872265 5.28083764460232e-05 3 CDH3|P-CADHERIN 1.33268713746002e-05 -0.317227756846777 4.33620590994454e-05 3 RAD50|RAD50 7.67727723103278e-10 -0.317353307254103 5.57882145455049e-09 3 AKT1 AKT2 AKT3|AKT_PS473 0.00228152343901474 -0.32055714629604 0.00473687723528775 3 GSK3A GSK3B|GSK3-ALPHA-BETA 2.44398889964997e-07 -0.323928735386535 1.10997829192436e-06 3 EEF2|EEF2 4.04785954664289e-07 -0.325835567608471 1.80088445136357e-06 3 PIK3R1 PIK3R2|PI3K-P85 1.7184524321658e-05 -0.348748756931921 5.42931348133543e-05 3 CCNB1|CYCLIN_B1 0.000630897764823364 -0.356200404961174 0.00146314588012227 3 PRKCA |PKC-ALPHA_PS657 1.52091925712367e-08 -0.357522033077434 7.53546359211273e-08 3 EGFR|EGFR_PY1068 0.000914851671037704 -0.379927730645136 0.00203507820700224 3 PRKCA |PKC-ALPHA 2.31192949849804e-12 -0.380157989796436 3.60000450480409e-11 3 RPTOR|RAPTOR 2.63419204265507e-12 -0.400905451483411 3.82835910199204e-11 3 EEF2K|EEF2K 2.06848769107897e-06 -0.412501841233173 7.9110581869336e-06 3 PRKAA1|AMPK_PT172 3.77106744547561e-05 -0.414030892339722 0.000109612360415158 3 CDH1|E-CADHERIN 0.000486402508544816 -0.430392729118499 0.00116522798750297 3 PXN|PAXILLIN 0.000527026428892427 -0.4430893340768 0.00124882349454945 3 RPS6KB1|P70S6K 2.7451921460212e-11 -0.447997436143273 2.99225943916311e-10 3 ACACA ACACB|ACC_PS79 5.35227655549141e-07 -0.461112679407543 2.28783586097476e-06 3 MSH6|MSH6 2.916902920826e-13 -0.464949052816731 6.35884836740068e-12 3 KDR|VEGFR2 0.000164366916852616 -0.466842098395572 0.000453569466757852 3 MTOR|MTOR 1.9087423910033e-11 -0.495666166620838 2.19003074336168e-10 3 GAB2|GAB2 3.4646896421781e-08 -0.534711082901637 1.67844964887739e-07 3 XRCC5|KU80 1.66153396224528e-16 -0.577220715688382 3.62214403769471e-14 3 MSH2|MSH2 1.78226406802866e-12 -0.589379537023882 3.2377797235854e-11 3 RICTOR|RICTOR 8.04522993394926e-08 -0.595831325689056 3.73161728851264e-07 3 NFKB1|NF-KB-P65_PS536 9.57519340529318e-10 -0.612713741611919 6.32543079501186e-09 3 NKX2-1|TTF1 0.0114664929008362 -0.619687853799528 0.0203227272551406 3 CTLA4|CTLA4 0.0233621957618771 -0.634060907989132 0.0388775471457191 3 FASN|FASN 7.13579151388763e-09 -0.667628744253587 3.98872448725001e-08 3 TP53BP1|53BP1 1.66680588136015e-14 -0.66996129611188 8.53652243539171e-13 3 PRKCB|PKC-PAN_BETAII_PS660 1.41604699669496e-10 -0.6796586364605 1.10249373314108e-09 3 GSK3A GSK3B|GSK3-ALPHA-BETA_PS21_S9 2.93366925054023e-11 -0.681345747674112 3.04542807913224e-10 3 ERBB2|HER2 1.59082730438329e-06 -0.685276098035576 6.19286343492066e-06 3 ACACA|ACC1 6.22896232019059e-12 -0.693603361911666 8.48696116125968e-11 3 MAPK1|ERK2 8.2099039763797e-09 -0.703810343106409 4.47439766712694e-08 3 RBM15|RBM15 9.42971395572231e-09 -0.708573415688818 5.01384790816455e-08 3 GSK3A GSK3B|GSK3_PS9 6.15535840347222e-13 -0.773096835926847 1.21988011996086e-11 3 TSC2|TUBERIN 7.57129044201576e-14 -0.781059531989238 2.35791616622777e-12 3 MYH9|MYOSIN-IIA_PS1943 1.01269080969561e-06 -0.801933134009295 4.16540748138949e-06 3 TUBA1B|ACETYL-A-TUBULIN-LYS40 9.49186977480801e-10 -0.866062384145612 6.32543079501186e-09 3 STAT5A|STAT5-ALPHA 8.86851328348047e-14 -0.868755792168801 2.41666986974843e-12 3 AKT1 AKT2 AKT3|AKT 1.02675662367141e-13 -0.875251590017738 2.48703271067075e-12 3 GAPDH|GAPDH 3.43714593720518e-10 -0.929282445598403 2.58378556658872e-09 3 BRAF|B-RAF 1.95791798976874e-14 -0.945979353277053 8.53652243539171e-13 3 ATM|ATM 1.1010234425653e-11 -0.952987961903698 1.41190064987786e-10 3 TSC1|TSC1 9.89972349891911e-15 -0.962834800436162 7.19379907588122e-13 3 CTNNB1|BETA-CATENIN 1.11486921015184e-10 -1.15593294573131 9.00153658567041e-10 3 VHL|VHL 4.09659175665732e-15 -1.92153178920416 4.46528501475648e-13 3