E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.074 0.196 -9999.0 0.0 -0.462 16.0 16.0 KLHL20 -0.013 0.098 0.177 2.0 -0.289 2.0 4.0 CYFIP2 0.02 0.057 -9999.0 0.0 -0.503 1.0 1.0 Rac1/GDP -0.031 0.125 -9999.0 0.0 -0.35 4.0 4.0 ENAH -0.074 0.197 -9999.0 0.0 -0.47 16.0 16.0 AP1M1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.025 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.01 0.098 -9999.0 0.0 -0.361 2.0 2.0 ABI1/Sra1/Nap1 -0.032 0.055 -9999.0 0.0 -0.174 5.0 5.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.007 0.136 -9999.0 0.0 -0.278 16.0 16.0 RAPGEF1 -0.056 0.171 -9999.0 0.0 -0.411 15.0 15.0 CTNND1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.075 0.204 -9999.0 0.0 -0.474 16.0 16.0 CRK -0.065 0.187 -9999.0 0.0 -0.435 16.0 16.0 E-cadherin/gamma catenin/alpha catenin -0.023 0.149 -9999.0 0.0 -0.325 16.0 16.0 alphaE/beta7 Integrin 0.028 0.059 -9999.0 0.0 -0.364 1.0 1.0 IQGAP1 0.021 0.057 -9999.0 0.0 -0.503 1.0 1.0 NCKAP1 0.022 0.057 -9999.0 0.0 -0.503 1.0 1.0 Rap1/GTP/I-afadin 0.039 0.053 -9999.0 0.0 -0.281 2.0 2.0 DLG1 -0.074 0.195 -9999.0 0.0 -0.461 16.0 16.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.023 0.065 -9999.0 0.0 -0.26 2.0 2.0 MLLT4 0.014 0.08 -9999.0 0.0 -0.503 2.0 2.0 ARF6/GTP/NME1/Tiam1 0.039 0.05 -9999.0 0.0 -0.282 1.0 1.0 PI3K -0.025 0.086 -9999.0 0.0 -0.343 2.0 2.0 ARF6 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.045 0.169 -9999.0 0.0 -0.38 17.0 17.0 TIAM1 0.009 0.082 -9999.0 0.0 -0.31 5.0 5.0 E-cadherin(dimer)/Ca2+ 0.001 0.119 -9999.0 0.0 -0.262 14.0 14.0 AKT1 -0.012 0.053 -9999.0 0.0 -0.192 2.0 2.0 PIK3R1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.064 0.2 -9999.0 0.0 -0.503 15.0 15.0 RhoA/GDP -0.02 0.137 0.465 1.0 -0.347 4.0 5.0 actin cytoskeleton organization -0.008 0.074 0.146 2.0 -0.259 1.0 3.0 CDC42/GDP -0.023 0.139 0.465 1.0 -0.37 3.0 4.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.035 0.113 -9999.0 0.0 -0.26 16.0 16.0 ITGB7 0.012 0.077 -9999.0 0.0 -0.322 4.0 4.0 RAC1 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.002 0.127 -9999.0 0.0 -0.279 14.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.008 0.113 -9999.0 0.0 -0.261 14.0 14.0 mol:GDP -0.042 0.153 0.484 1.0 -0.344 12.0 13.0 CDC42/GTP/IQGAP1 0.031 0.038 -9999.0 0.0 -0.308 1.0 1.0 JUP 0.008 0.097 -9999.0 0.0 -0.503 3.0 3.0 p120 catenin/RhoA/GDP -0.024 0.139 0.46 1.0 -0.356 4.0 5.0 RAC1/GTP/IQGAP1 0.03 0.039 -9999.0 0.0 -0.309 1.0 1.0 PIP5K1C/AP1M1 0.041 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.004 0.077 0.188 3.0 -0.212 5.0 8.0 NME1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.07 0.201 -9999.0 0.0 -0.483 15.0 15.0 regulation of cell-cell adhesion -0.017 0.082 -9999.0 0.0 -0.313 2.0 2.0 WASF2 -0.003 0.039 -9999.0 0.0 -0.139 1.0 1.0 Rap1/GTP -0.011 0.111 -9999.0 0.0 -0.411 2.0 2.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.01 0.144 -9999.0 0.0 -0.279 17.0 17.0 CCND1 -0.007 0.092 0.212 3.0 -0.265 5.0 8.0 VAV2 -0.073 0.215 -9999.0 0.0 -0.553 8.0 8.0 RAP1/GDP -0.013 0.117 -9999.0 0.0 -0.397 2.0 2.0 adherens junction assembly -0.067 0.194 -9999.0 0.0 -0.466 15.0 15.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.008 0.141 -9999.0 0.0 -0.273 14.0 14.0 E-cadherin/beta catenin -0.054 0.142 -9999.0 0.0 -0.351 16.0 16.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.077 0.196 -9999.0 0.0 -0.462 16.0 16.0 PIK3CA 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.072 0.125 -9999.0 0.0 -0.372 6.0 6.0 E-cadherin/beta catenin/alpha catenin -0.011 0.132 -9999.0 0.0 -0.307 14.0 14.0 ITGAE 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.078 0.208 -9999.0 0.0 -0.485 16.0 16.0