Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.109 0.249 -9999.0 0.0 -0.573 16.0 16.0 IHH -0.027 0.088 -9999.0 0.0 -0.233 6.0 6.0 SHH Np/Cholesterol/GAS1 -0.001 0.078 -9999.0 0.0 -0.359 3.0 3.0 LRPAP1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.001 0.077 0.357 3.0 -9999.0 0.0 3.0 SMO/beta Arrestin2 -0.037 0.151 -9999.0 0.0 -0.509 3.0 3.0 SMO -0.053 0.148 -9999.0 0.0 -0.487 4.0 4.0 AKT1 -0.009 0.106 -9999.0 0.0 -0.382 4.0 4.0 ARRB2 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.005 0.087 -9999.0 0.0 -0.302 6.0 6.0 ADRBK1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.047 0.149 -9999.0 0.0 -0.479 4.0 4.0 STIL -0.042 0.152 -9999.0 0.0 -0.396 6.0 6.0 DHH N/PTCH2 -0.026 0.128 -9999.0 0.0 -0.366 7.0 7.0 DHH N/PTCH1 -0.067 0.173 -9999.0 0.0 -0.364 18.0 18.0 PIK3CA 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.004 0.118 -9999.0 0.0 -0.422 6.0 6.0 PTHLH -0.127 0.31 -9999.0 0.0 -0.993 8.0 8.0 determination of left/right symmetry -0.047 0.149 -9999.0 0.0 -0.479 4.0 4.0 PIK3R1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.125 0.305 -9999.0 0.0 -0.922 9.0 9.0 IHH N/Hhip -0.139 0.167 -9999.0 0.0 -0.29 43.0 43.0 DHH N/Hhip -0.114 0.183 -9999.0 0.0 -0.278 42.0 42.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.047 0.149 -9999.0 0.0 -0.479 4.0 4.0 pancreas development -0.158 0.204 -9999.0 0.0 -0.347 43.0 43.0 HHAT 0.026 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.04 0.011 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.007 0.121 -9999.0 0.0 -0.399 7.0 7.0 somite specification -0.047 0.149 -9999.0 0.0 -0.479 4.0 4.0 SHH Np/Cholesterol/PTCH1 -0.056 0.137 -9999.0 0.0 -0.375 7.0 7.0 SHH Np/Cholesterol/PTCH2 -0.013 0.073 -9999.0 0.0 -0.286 2.0 2.0 SHH Np/Cholesterol/Megalin -0.051 0.138 -9999.0 0.0 -0.293 20.0 20.0 SHH -0.006 0.029 -9999.0 0.0 -9999.0 0.0 0.0 catabolic process -0.07 0.172 -9999.0 0.0 -0.38 17.0 17.0 SMO/Vitamin D3 -0.036 0.151 -9999.0 0.0 -0.499 3.0 3.0 SHH Np/Cholesterol/Hhip -0.071 0.123 -9999.0 0.0 -0.276 17.0 17.0 LRP2 -0.111 0.225 -9999.0 0.0 -0.455 25.0 25.0 receptor-mediated endocytosis -0.092 0.173 -9999.0 0.0 -0.442 9.0 9.0 SHH Np/Cholesterol/BOC 0.006 0.054 -9999.0 0.0 -0.286 1.0 1.0 SHH Np/Cholesterol/CDO -0.017 0.108 -9999.0 0.0 -0.313 10.0 10.0 mesenchymal cell differentiation 0.071 0.123 0.275 17.0 -9999.0 0.0 17.0 mol:Vitamin D3 -0.036 0.158 -9999.0 0.0 -0.376 7.0 7.0 IHH N/PTCH2 -0.038 0.12 -9999.0 0.0 -0.258 16.0 16.0 CDON -0.034 0.169 -9999.0 0.0 -0.503 10.0 10.0 IHH N/PTCH1 -0.057 0.179 -9999.0 0.0 -0.382 17.0 17.0 Megalin/LRPAP1 -0.065 0.171 -9999.0 0.0 -0.325 25.0 25.0 PTCH2 -0.032 0.13 -9999.0 0.0 -0.296 16.0 16.0 SHH Np/Cholesterol 0.009 0.024 -9999.0 0.0 -9999.0 0.0 0.0 PTCH1 -0.07 0.172 -9999.0 0.0 -0.381 17.0 17.0 HHIP -0.158 0.204 -9999.0 0.0 -0.347 43.0 43.0