Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.032 0.112 -9999.0 0.0 -0.252 17.0 17.0 epithelial cell differentiation -0.003 0.116 -9999.0 0.0 -0.26 14.0 14.0 CYFIP2 0.02 0.057 -9999.0 0.0 -0.503 1.0 1.0 ENAH -0.026 0.118 0.35 2.0 -0.346 5.0 7.0 EGFR -0.01 0.134 -9999.0 0.0 -0.503 6.0 6.0 EPHA2 0.021 0.057 -9999.0 0.0 -0.503 1.0 1.0 MYO6 -0.015 0.124 0.339 2.0 -0.249 15.0 17.0 CTNNB1 0.025 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.042 0.057 -9999.0 0.0 -0.309 2.0 2.0 AQP5 -0.079 0.173 -9999.0 0.0 -0.476 11.0 11.0 CTNND1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.014 0.114 0.349 1.0 -0.249 11.0 12.0 regulation of calcium-dependent cell-cell adhesion -0.033 0.132 0.337 2.0 -0.268 13.0 15.0 EGF -0.016 0.135 -9999.0 0.0 -0.396 9.0 9.0 NCKAP1 0.022 0.057 -9999.0 0.0 -0.503 1.0 1.0 AQP3 -0.044 0.13 -9999.0 0.0 -0.54 3.0 3.0 cortical microtubule organization -0.003 0.116 -9999.0 0.0 -0.26 14.0 14.0 GO:0000145 -0.027 0.106 0.338 1.0 -0.238 11.0 12.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.001 0.119 -9999.0 0.0 -0.262 14.0 14.0 MLLT4 0.014 0.08 -9999.0 0.0 -0.503 2.0 2.0 ARF6/GDP -0.043 0.124 -9999.0 0.0 -0.472 5.0 5.0 ARF6 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.04 0.098 -9999.0 0.0 -0.329 5.0 5.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.025 0.093 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.015 0.114 0.339 2.0 -0.25 13.0 15.0 ARF6/GTP 0.047 0.095 -9999.0 0.0 -0.308 5.0 5.0 CDH1 -0.064 0.2 -9999.0 0.0 -0.503 15.0 15.0 EGFR/EGFR/EGF/EGF -0.039 0.146 -9999.0 0.0 -0.296 16.0 16.0 RhoA/GDP -0.0 0.111 -9999.0 0.0 -0.247 14.0 14.0 actin cytoskeleton organization -0.019 0.119 0.324 2.0 -0.248 11.0 13.0 IGF-1R heterotetramer -0.001 0.114 -9999.0 0.0 -0.454 5.0 5.0 GIT1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R -0.001 0.115 -9999.0 0.0 -0.455 5.0 5.0 IGF1 -0.029 0.153 -9999.0 0.0 -0.415 11.0 11.0 DIAPH1 -0.003 0.18 -9999.0 0.0 -0.675 4.0 4.0 Wnt receptor signaling pathway 0.003 0.116 0.26 14.0 -9999.0 0.0 14.0 RHOA 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.052 0.121 -9999.0 0.0 -0.472 5.0 5.0 CTNNA1 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.02 0.121 0.327 2.0 -0.253 11.0 13.0 EFNA1 -0.004 0.123 -9999.0 0.0 -0.503 5.0 5.0 LPP -0.026 0.105 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.018 0.151 -9999.0 0.0 -0.372 11.0 11.0 SEC6/SEC8 -0.026 0.099 -9999.0 0.0 -0.402 3.0 3.0 MGAT3 -0.033 0.134 0.339 2.0 -0.271 13.0 15.0 HGF/MET -0.071 0.163 -9999.0 0.0 -0.329 18.0 18.0 HGF -0.06 0.166 -9999.0 0.0 -0.346 20.0 20.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.032 0.113 -9999.0 0.0 -0.253 17.0 17.0 actin cable formation 0.021 0.153 0.35 8.0 -0.365 3.0 11.0 KIAA1543 -0.032 0.124 0.33 2.0 -0.261 12.0 14.0 KIFC3 -0.019 0.109 -9999.0 0.0 -0.25 14.0 14.0 NCK1 0.029 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.025 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.011 0.121 0.339 2.0 -0.253 11.0 13.0 NCK1/GIT1 0.04 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.003 0.116 -9999.0 0.0 -0.26 14.0 14.0 EXOC4 0.027 0.007 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.021 0.107 -9999.0 0.0 -0.25 14.0 14.0 PIP5K1C -0.014 0.116 0.352 1.0 -0.253 11.0 12.0 LIMA1 0.01 0.097 -9999.0 0.0 -0.503 3.0 3.0 ABI1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.001 0.155 0.414 4.0 -0.411 5.0 9.0 adherens junction assembly -0.014 0.144 0.466 2.0 -0.51 2.0 4.0 IGF-1R heterotetramer/IGF1 -0.042 0.14 -9999.0 0.0 -0.279 20.0 20.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.028 0.063 -9999.0 0.0 -0.364 2.0 2.0 MET -0.023 0.153 -9999.0 0.0 -0.503 8.0 8.0 PLEKHA7 -0.019 0.133 0.339 2.0 -0.265 15.0 17.0 mol:GTP 0.039 0.097 -9999.0 0.0 -0.327 5.0 5.0 establishment of epithelial cell apical/basal polarity 0.001 0.135 0.43 3.0 -0.437 2.0 5.0 cortical actin cytoskeleton stabilization -0.032 0.112 -9999.0 0.0 -0.252 17.0 17.0 regulation of cell-cell adhesion -0.019 0.119 0.324 2.0 -0.248 11.0 13.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.032 0.113 -9999.0 0.0 -0.253 17.0 17.0