Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.02 0.046 -9999.0 0.0 -0.279 7.0 7.0 epithelial cell differentiation -0.008 0.052 -9999.0 0.0 -0.344 7.0 7.0 CYFIP2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ENAH 0.047 0.045 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.012 0.12 -9999.0 0.0 -0.592 12.0 12.0 EPHA2 0.008 0.045 -9999.0 0.0 -0.531 2.0 2.0 MYO6 0.022 0.072 -9999.0 0.0 -0.422 7.0 7.0 CTNNB1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.025 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.071 0.17 -9999.0 0.0 -0.528 34.0 34.0 CTNND1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.024 0.053 -9999.0 0.0 -0.32 7.0 7.0 regulation of calcium-dependent cell-cell adhesion -0.005 0.112 -9999.0 0.0 -0.334 30.0 30.0 EGF -0.068 0.195 -9999.0 0.0 -0.515 46.0 46.0 NCKAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.025 0.096 -9999.0 0.0 -0.505 9.0 9.0 cortical microtubule organization -0.008 0.052 -9999.0 0.0 -0.344 7.0 7.0 GO:0000145 0.023 0.05 -9999.0 0.0 -0.305 7.0 7.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.02 0.057 -9999.0 0.0 -0.348 7.0 7.0 MLLT4 0.008 0.054 -9999.0 0.0 -0.653 2.0 2.0 ARF6/GDP -0.009 0.046 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.027 0.037 -9999.0 0.0 -0.368 2.0 2.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.033 0.052 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.01 0.038 -9999.0 0.0 -0.653 1.0 1.0 ZYX 0.024 0.054 -9999.0 0.0 -0.325 7.0 7.0 ARF6/GTP 0.03 0.034 -9999.0 0.0 -0.337 2.0 2.0 CDH1 -0.001 0.093 -9999.0 0.0 -0.653 6.0 6.0 EGFR/EGFR/EGF/EGF -0.052 0.11 -9999.0 0.0 -0.404 4.0 4.0 RhoA/GDP -0.007 0.048 -9999.0 0.0 -0.321 7.0 7.0 actin cytoskeleton organization 0.026 0.076 -9999.0 0.0 -0.62 3.0 3.0 IGF-1R heterotetramer -0.01 0.119 -9999.0 0.0 -0.652 10.0 10.0 GIT1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R -0.01 0.119 -9999.0 0.0 -0.653 10.0 10.0 IGF1 -0.034 0.157 -9999.0 0.0 -0.546 25.0 25.0 DIAPH1 -0.0 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway 0.008 0.052 0.344 7.0 -9999.0 0.0 7.0 RHOA 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.009 0.046 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.01 0.038 -9999.0 0.0 -0.653 1.0 1.0 VCL 0.026 0.078 -9999.0 0.0 -0.642 3.0 3.0 EFNA1 0.008 0.045 -9999.0 0.0 -0.531 2.0 2.0 LPP 0.029 0.055 -9999.0 0.0 -0.314 1.0 1.0 Ephrin A1/EPHA2 -0.01 0.054 -9999.0 0.0 -0.31 9.0 9.0 SEC6/SEC8 -0.009 0.056 -9999.0 0.0 -0.591 1.0 1.0 MGAT3 -0.006 0.114 -9999.0 0.0 -0.34 30.0 30.0 HGF/MET -0.052 0.127 -9999.0 0.0 -0.594 6.0 6.0 HGF -0.034 0.162 -9999.0 0.0 -0.589 23.0 23.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.02 0.046 -9999.0 0.0 -0.281 7.0 7.0 actin cable formation 0.062 0.042 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 0.022 0.097 -9999.0 0.0 -0.713 4.0 4.0 KIFC3 0.024 0.054 -9999.0 0.0 -0.325 7.0 7.0 NCK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.024 0.054 -9999.0 0.0 -0.325 7.0 7.0 NCK1/GIT1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.008 0.052 -9999.0 0.0 -0.344 7.0 7.0 EXOC4 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.024 0.054 -9999.0 0.0 -0.325 7.0 7.0 PIP5K1C 0.024 0.054 -9999.0 0.0 -0.325 7.0 7.0 LIMA1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.044 0.05 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.037 0.092 -9999.0 0.0 -0.659 4.0 4.0 IGF-1R heterotetramer/IGF1 -0.038 0.108 -9999.0 0.0 -0.347 29.0 29.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.013 0.05 -9999.0 0.0 -0.483 3.0 3.0 MET -0.04 0.173 -9999.0 0.0 -0.597 26.0 26.0 PLEKHA7 0.022 0.067 -9999.0 0.0 -0.368 8.0 8.0 mol:GTP 0.026 0.037 -9999.0 0.0 -0.366 2.0 2.0 establishment of epithelial cell apical/basal polarity 0.042 0.062 -9999.0 0.0 -0.56 1.0 1.0 cortical actin cytoskeleton stabilization 0.02 0.046 -9999.0 0.0 -0.279 7.0 7.0 regulation of cell-cell adhesion 0.026 0.076 -9999.0 0.0 -0.62 3.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.02 0.046 -9999.0 0.0 -0.281 7.0 7.0