Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.023 0.184 -9999.0 0.0 -0.658 22.0 22.0 IHH 0.009 0.069 -9999.0 0.0 -0.271 8.0 8.0 SHH Np/Cholesterol/GAS1 -0.023 0.111 -9999.0 0.0 -0.305 37.0 37.0 LRPAP1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.023 0.11 0.303 37.0 -9999.0 0.0 37.0 SMO/beta Arrestin2 0.013 0.104 -9999.0 0.0 -0.392 5.0 5.0 SMO -0.009 0.1 -9999.0 0.0 -0.391 8.0 8.0 AKT1 -0.002 0.079 -9999.0 0.0 -0.416 1.0 1.0 ARRB2 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.018 0.061 -9999.0 0.0 -0.489 4.0 4.0 ADRBK1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.007 0.1 -9999.0 0.0 -0.386 8.0 8.0 STIL -0.024 0.112 -9999.0 0.0 -0.397 9.0 9.0 DHH N/PTCH2 0.009 0.095 -9999.0 0.0 -0.355 18.0 18.0 DHH N/PTCH1 0.007 0.107 -9999.0 0.0 -0.305 29.0 29.0 PIK3CA 0.023 0.011 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.012 0.084 -9999.0 0.0 -0.489 8.0 8.0 PTHLH -0.029 0.2 -9999.0 0.0 -0.718 20.0 20.0 determination of left/right symmetry -0.007 0.1 -9999.0 0.0 -0.386 8.0 8.0 PIK3R1 0.025 0.011 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.029 0.197 -9999.0 0.0 -0.709 20.0 20.0 IHH N/Hhip -0.022 0.135 -9999.0 0.0 -0.387 33.0 33.0 DHH N/Hhip -0.021 0.136 -9999.0 0.0 -0.371 37.0 37.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.007 0.1 -9999.0 0.0 -0.386 8.0 8.0 pancreas development -0.035 0.156 -9999.0 0.0 -0.488 31.0 31.0 HHAT 0.007 0.101 -9999.0 0.0 -0.489 12.0 12.0 PI3K 0.03 0.02 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.001 0.116 -9999.0 0.0 -0.489 16.0 16.0 somite specification -0.007 0.1 -9999.0 0.0 -0.386 8.0 8.0 SHH Np/Cholesterol/PTCH1 -0.022 0.112 -9999.0 0.0 -0.365 13.0 13.0 SHH Np/Cholesterol/PTCH2 -0.02 0.099 -9999.0 0.0 -0.291 33.0 33.0 SHH Np/Cholesterol/Megalin -0.085 0.136 -9999.0 0.0 -0.287 89.0 89.0 SHH -0.033 0.101 -9999.0 0.0 -0.368 24.0 24.0 catabolic process -0.0 0.101 -9999.0 0.0 -0.338 23.0 23.0 SMO/Vitamin D3 -0.018 0.121 -9999.0 0.0 -0.435 8.0 8.0 SHH Np/Cholesterol/Hhip -0.043 0.128 -9999.0 0.0 -0.319 48.0 48.0 LRP2 -0.117 0.215 -9999.0 0.0 -0.489 74.0 74.0 receptor-mediated endocytosis -0.073 0.137 -9999.0 0.0 -0.474 10.0 10.0 SHH Np/Cholesterol/BOC -0.011 0.087 -9999.0 0.0 -0.28 26.0 26.0 SHH Np/Cholesterol/CDO -0.01 0.094 -9999.0 0.0 -0.306 25.0 25.0 mesenchymal cell differentiation 0.043 0.127 0.317 48.0 -9999.0 0.0 48.0 mol:Vitamin D3 -0.018 0.119 -9999.0 0.0 -0.386 11.0 11.0 IHH N/PTCH2 0.011 0.093 -9999.0 0.0 -0.388 13.0 13.0 CDON 0.021 0.052 -9999.0 0.0 -0.489 3.0 3.0 IHH N/PTCH1 0.009 0.104 -9999.0 0.0 -0.34 23.0 23.0 Megalin/LRPAP1 -0.075 0.163 -9999.0 0.0 -0.355 74.0 74.0 PTCH2 0.003 0.098 -9999.0 0.0 -0.489 11.0 11.0 SHH Np/Cholesterol -0.014 0.082 -9999.0 0.0 -0.283 24.0 24.0 PTCH1 -0.0 0.101 -9999.0 0.0 -0.339 23.0 23.0 HHIP -0.035 0.156 -9999.0 0.0 -0.489 31.0 31.0