Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.018 0.034 -9999.0 0.0 -0.232 4.0 4.0 epithelial cell differentiation 0.048 0.043 -9999.0 0.0 -0.259 4.0 4.0 CYFIP2 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.007 0.05 0.273 1.0 -9999.0 0.0 1.0 EGFR 0.011 0.088 -9999.0 0.0 -0.489 9.0 9.0 EPHA2 0.026 0.03 -9999.0 0.0 -0.489 1.0 1.0 MYO6 -0.015 0.044 0.181 2.0 -0.309 5.0 7.0 CTNNB1 0.028 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.054 0.015 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.044 0.151 -9999.0 0.0 -0.467 32.0 32.0 CTNND1 0.028 0.002 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.013 0.033 0.18 2.0 -0.247 4.0 6.0 regulation of calcium-dependent cell-cell adhesion -0.032 0.073 0.18 2.0 -0.251 28.0 30.0 EGF -0.011 0.123 -9999.0 0.0 -0.489 18.0 18.0 NCKAP1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.01 0.088 -9999.0 0.0 -0.42 10.0 10.0 cortical microtubule organization 0.048 0.043 -9999.0 0.0 -0.259 4.0 4.0 GO:0000145 -0.013 0.031 0.17 2.0 -0.236 4.0 6.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.054 0.045 -9999.0 0.0 -0.261 4.0 4.0 MLLT4 0.024 0.031 -9999.0 0.0 -0.489 1.0 1.0 ARF6/GDP -0.021 0.027 -9999.0 0.0 -0.232 4.0 4.0 ARF6 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.061 0.033 -9999.0 0.0 -0.278 1.0 1.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.001 0.03 0.185 1.0 -0.234 3.0 4.0 PVRL2 0.024 0.031 -9999.0 0.0 -0.489 1.0 1.0 ZYX -0.013 0.034 0.181 2.0 -0.251 4.0 6.0 ARF6/GTP 0.066 0.035 -9999.0 0.0 -0.261 1.0 1.0 CDH1 0.018 0.06 -9999.0 0.0 -0.489 4.0 4.0 EGFR/EGFR/EGF/EGF 0.014 0.091 -9999.0 0.0 -0.249 30.0 30.0 RhoA/GDP 0.05 0.042 -9999.0 0.0 -0.249 4.0 4.0 actin cytoskeleton organization -0.016 0.045 0.167 2.0 -0.303 6.0 8.0 IGF-1R heterotetramer 0.01 0.093 -9999.0 0.0 -0.488 10.0 10.0 GIT1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.01 0.093 -9999.0 0.0 -0.489 10.0 10.0 IGF1 0.001 0.109 -9999.0 0.0 -0.489 14.0 14.0 DIAPH1 0.042 0.097 -9999.0 0.0 -0.534 4.0 4.0 Wnt receptor signaling pathway -0.048 0.043 0.259 4.0 -9999.0 0.0 4.0 RHOA 0.028 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.021 0.027 -9999.0 0.0 -0.233 4.0 4.0 CTNNA1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.017 0.046 0.168 2.0 -0.31 6.0 8.0 EFNA1 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.012 0.03 0.175 2.0 -0.237 3.0 5.0 Ephrin A1/EPHA2 0.041 0.042 -9999.0 0.0 -0.246 4.0 4.0 SEC6/SEC8 -0.019 0.034 -9999.0 0.0 -0.247 6.0 6.0 MGAT3 -0.032 0.074 0.181 2.0 -0.255 28.0 30.0 HGF/MET 0.008 0.103 -9999.0 0.0 -0.256 37.0 37.0 HGF -0.002 0.116 -9999.0 0.0 -0.489 16.0 16.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.018 0.035 -9999.0 0.0 -0.234 4.0 4.0 actin cable formation 0.034 0.07 0.28 7.0 -9999.0 0.0 7.0 KIAA1543 -0.015 0.038 0.171 2.0 -0.25 6.0 8.0 KIFC3 -0.014 0.031 0.177 1.0 -0.251 4.0 5.0 NCK1 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.025 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.013 0.033 0.181 2.0 -0.246 4.0 6.0 NCK1/GIT1 0.038 0.012 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.048 0.043 -9999.0 0.0 -0.259 4.0 4.0 EXOC4 0.027 0.006 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.013 0.034 0.181 2.0 -0.251 4.0 6.0 PIP5K1C -0.013 0.033 0.181 2.0 -0.251 4.0 6.0 LIMA1 0.028 0.002 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.004 0.059 0.293 2.0 -9999.0 0.0 2.0 adherens junction assembly -0.032 0.126 -9999.0 0.0 -0.681 9.0 9.0 IGF-1R heterotetramer/IGF1 0.018 0.09 -9999.0 0.0 -0.257 27.0 27.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.033 0.036 -9999.0 0.0 -0.355 2.0 2.0 MET -0.008 0.129 -9999.0 0.0 -0.489 20.0 20.0 PLEKHA7 -0.015 0.04 0.181 2.0 -0.261 6.0 8.0 mol:GTP 0.058 0.032 -9999.0 0.0 -0.276 1.0 1.0 establishment of epithelial cell apical/basal polarity 0.013 0.085 0.322 5.0 -0.284 1.0 6.0 cortical actin cytoskeleton stabilization 0.018 0.034 -9999.0 0.0 -0.232 4.0 4.0 regulation of cell-cell adhesion -0.016 0.045 0.167 2.0 -0.303 6.0 8.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.018 0.035 -9999.0 0.0 -0.234 4.0 4.0