E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.045 0.101 -9999.0 0.0 -0.323 62.0 62.0 KLHL20 -0.057 0.079 0.468 1.0 -0.259 26.0 27.0 CYFIP2 0.029 0.006 -9999.0 0.0 0.0 24.0 24.0 Rac1/GDP -0.044 0.079 0.231 6.0 -0.248 21.0 27.0 ENAH -0.046 0.102 -9999.0 0.0 -0.321 64.0 64.0 AP1M1 0.026 0.01 -9999.0 0.0 0.0 65.0 65.0 RAP1B 0.029 0.006 -9999.0 0.0 0.0 23.0 23.0 RAP1A 0.029 0.004 -9999.0 0.0 0.0 8.0 8.0 CTNNB1 0.029 0.004 -9999.0 0.0 0.0 8.0 8.0 CDC42/GTP -0.057 0.051 0.117 22.0 -0.233 2.0 24.0 ABI1/Sra1/Nap1 -0.052 0.045 -9999.0 0.0 -0.168 35.0 35.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.057 0.047 -9999.0 0.0 -0.142 8.0 8.0 RAPGEF1 -0.045 0.098 0.238 4.0 -0.307 53.0 57.0 CTNND1 0.029 0.003 -9999.0 0.0 0.0 5.0 5.0 regulation of calcium-dependent cell-cell adhesion -0.022 0.113 -9999.0 0.0 -0.322 66.0 66.0 CRK -0.045 0.101 -9999.0 0.0 -0.316 59.0 59.0 E-cadherin/gamma catenin/alpha catenin 0.044 0.043 -9999.0 0.0 -0.157 18.0 18.0 alphaE/beta7 Integrin 0.041 0.014 -9999.0 0.0 -0.164 1.0 1.0 IQGAP1 0.029 0.006 -9999.0 0.0 0.0 24.0 24.0 NCKAP1 0.029 0.005 -9999.0 0.0 0.0 17.0 17.0 Rap1/GTP/I-afadin 0.04 0.043 -9999.0 0.0 -0.131 21.0 21.0 DLG1 -0.031 0.102 0.192 1.0 -0.323 52.0 53.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.043 0.042 -9999.0 0.0 -0.152 12.0 12.0 MLLT4 0.026 0.01 -9999.0 0.0 0.0 72.0 72.0 ARF6/GTP/NME1/Tiam1 0.048 0.024 -9999.0 0.0 -0.131 1.0 1.0 PI3K -0.053 0.053 -9999.0 0.0 -0.207 7.0 7.0 ARF6 0.029 0.004 -9999.0 0.0 0.0 11.0 11.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.031 0.041 -9999.0 0.0 -0.177 18.0 18.0 TIAM1 0.028 0.006 -9999.0 0.0 -0.001 24.0 24.0 E-cadherin(dimer)/Ca2+ 0.053 0.042 -9999.0 0.0 -0.132 7.0 7.0 AKT1 -0.012 0.069 0.136 51.0 -0.145 1.0 52.0 PIK3R1 0.021 0.013 -9999.0 0.0 0.0 159.0 159.0 CDH1 0.026 0.01 -9999.0 0.0 -0.0 70.0 70.0 RhoA/GDP -0.043 0.08 0.232 6.0 -0.248 20.0 26.0 actin cytoskeleton organization -0.043 0.059 0.405 1.0 -0.198 17.0 18.0 CDC42/GDP -0.042 0.08 0.232 6.0 -0.248 20.0 26.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.013 0.057 -9999.0 0.0 -0.189 33.0 33.0 ITGB7 0.029 0.004 -9999.0 0.0 0.0 8.0 8.0 RAC1 0.028 0.007 -9999.0 0.0 -0.001 27.0 27.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.058 0.045 -9999.0 0.0 -0.142 7.0 7.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.04 0.032 -9999.0 0.0 -0.122 7.0 7.0 mol:GDP -0.042 0.085 0.233 6.0 -0.27 23.0 29.0 CDC42/GTP/IQGAP1 0.037 0.014 -9999.0 0.0 -0.134 2.0 2.0 JUP 0.028 0.008 -9999.0 0.0 0.0 40.0 40.0 p120 catenin/RhoA/GDP -0.045 0.083 0.239 6.0 -0.255 18.0 24.0 RAC1/GTP/IQGAP1 0.036 0.015 -9999.0 0.0 -0.134 2.0 2.0 PIP5K1C/AP1M1 0.037 0.017 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.029 0.003 -9999.0 0.0 0.0 7.0 7.0 CDC42 0.029 0.004 -9999.0 0.0 0.0 13.0 13.0 CTNNA1 0.029 0.004 -9999.0 0.0 0.0 13.0 13.0 positive regulation of S phase of mitotic cell cycle -0.044 0.057 0.092 3.0 -0.13 144.0 147.0 NME1 0.027 0.008 -9999.0 0.0 0.0 42.0 42.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.047 0.104 -9999.0 0.0 -0.322 66.0 66.0 regulation of cell-cell adhesion -0.053 0.041 0.083 21.0 -0.207 2.0 23.0 WASF2 -0.03 0.035 0.096 5.0 -0.105 34.0 39.0 Rap1/GTP -0.053 0.058 0.252 2.0 -0.252 2.0 4.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.058 0.063 -9999.0 0.0 -0.152 18.0 18.0 CCND1 -0.054 0.07 0.113 2.0 -0.158 146.0 148.0 VAV2 -0.038 0.165 -9999.0 0.0 -0.628 27.0 27.0 RAP1/GDP -0.044 0.067 0.243 4.0 -0.245 4.0 8.0 adherens junction assembly -0.045 0.101 -9999.0 0.0 -0.313 66.0 66.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.029 0.005 -9999.0 0.0 0.0 14.0 14.0 PIP5K1C 0.027 0.008 -9999.0 0.0 0.0 44.0 44.0 regulation of heterotypic cell-cell adhesion -0.06 0.03 0.172 4.0 -0.229 2.0 6.0 E-cadherin/beta catenin -0.009 0.048 -9999.0 0.0 -0.179 37.0 37.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.044 0.1 -9999.0 0.0 -0.325 60.0 60.0 PIK3CA 0.02 0.014 -9999.0 0.0 0.0 174.0 174.0 Rac1/GTP -0.088 0.112 0.553 1.0 -0.386 37.0 38.0 E-cadherin/beta catenin/alpha catenin 0.049 0.03 -9999.0 0.0 -0.146 7.0 7.0 ITGAE 0.028 0.007 -9999.0 0.0 0.0 30.0 30.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.022 0.115 -9999.0 0.0 -0.328 66.0 66.0