Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.01 0.057 -9999.0 0.0 -0.198 26.0 26.0 epithelial cell differentiation 0.048 0.039 -9999.0 0.0 -0.131 7.0 7.0 CYFIP2 0.029 0.006 -9999.0 0.0 0.0 24.0 24.0 ENAH -0.049 0.061 0.21 6.0 -9999.0 0.0 6.0 EGFR 0.027 0.009 -9999.0 0.0 0.0 55.0 55.0 EPHA2 0.029 0.005 -9999.0 0.0 0.0 16.0 16.0 MYO6 -0.046 0.027 0.157 5.0 -0.218 1.0 6.0 CTNNB1 0.029 0.004 -9999.0 0.0 0.0 8.0 8.0 ABI1/Sra1/Nap1 0.052 0.03 -9999.0 0.0 -0.146 9.0 9.0 AQP5 -0.011 0.049 -9999.0 0.0 -0.322 4.0 4.0 CTNND1 0.03 0.003 -9999.0 0.0 0.0 5.0 5.0 mol:PI-4-5-P2 -0.044 0.027 0.156 5.0 -9999.0 0.0 5.0 regulation of calcium-dependent cell-cell adhesion -0.044 0.028 0.156 5.0 -9999.0 0.0 5.0 EGF 0.028 0.008 -9999.0 0.0 0.0 41.0 41.0 NCKAP1 0.029 0.005 -9999.0 0.0 0.0 17.0 17.0 AQP3 -0.126 0.167 -9999.0 0.0 -0.389 154.0 154.0 cortical microtubule organization 0.048 0.039 -9999.0 0.0 -0.131 7.0 7.0 GO:0000145 -0.042 0.025 0.139 5.0 -9999.0 0.0 5.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.054 0.042 -9999.0 0.0 -0.132 7.0 7.0 MLLT4 0.026 0.01 -9999.0 0.0 0.0 72.0 72.0 ARF6/GDP -0.064 0.034 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.029 0.004 -9999.0 0.0 0.0 11.0 11.0 Ephrin A1/EPHA2/NCK1/GIT1 0.068 0.039 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.049 0.066 -9999.0 0.0 -0.226 58.0 58.0 PVRL2 0.028 0.007 -9999.0 0.0 0.0 33.0 33.0 ZYX -0.041 0.027 0.156 2.0 -0.218 1.0 3.0 ARF6/GTP 0.073 0.043 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.026 0.01 -9999.0 0.0 0.0 69.0 69.0 EGFR/EGFR/EGF/EGF -0.061 0.031 0.092 6.0 -0.219 2.0 8.0 RhoA/GDP 0.048 0.043 -9999.0 0.0 -0.134 8.0 8.0 actin cytoskeleton organization -0.05 0.028 0.134 5.0 -0.223 1.0 6.0 IGF-1R heterotetramer 0.022 0.013 -9999.0 0.0 0.0 141.0 141.0 GIT1 0.028 0.007 -9999.0 0.0 0.0 30.0 30.0 IGF1R 0.022 0.013 -9999.0 0.0 0.0 141.0 141.0 IGF1 0.028 0.007 -9999.0 0.0 0.0 32.0 32.0 DIAPH1 0.029 0.127 -9999.0 0.0 -0.551 20.0 20.0 Wnt receptor signaling pathway -0.048 0.039 0.131 7.0 -9999.0 0.0 7.0 RHOA 0.029 0.003 -9999.0 0.0 0.0 7.0 7.0 RhoA/GTP -0.065 0.034 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.029 0.004 -9999.0 0.0 0.0 13.0 13.0 VCL -0.051 0.028 0.135 5.0 -0.228 1.0 6.0 EFNA1 0.027 0.008 -9999.0 0.0 0.0 44.0 44.0 LPP -0.046 0.035 0.14 5.0 -0.298 1.0 6.0 Ephrin A1/EPHA2 -0.05 0.032 0.092 20.0 -0.14 6.0 26.0 SEC6/SEC8 -0.063 0.034 -9999.0 0.0 -0.227 1.0 1.0 MGAT3 -0.044 0.028 0.157 5.0 -9999.0 0.0 5.0 HGF/MET -0.044 0.047 0.092 48.0 -9999.0 0.0 48.0 HGF 0.029 0.005 -9999.0 0.0 0.0 16.0 16.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.01 0.058 -9999.0 0.0 -0.199 26.0 26.0 actin cable formation -0.029 0.087 0.258 15.0 -0.268 11.0 26.0 KIAA1543 -0.046 0.023 0.14 5.0 -9999.0 0.0 5.0 KIFC3 -0.046 0.025 0.158 3.0 -9999.0 0.0 3.0 NCK1 0.026 0.009 -9999.0 0.0 0.0 63.0 63.0 EXOC3 0.027 0.009 -9999.0 0.0 0.0 58.0 58.0 ACTN1 -0.046 0.027 0.157 5.0 -0.218 1.0 6.0 NCK1/GIT1 0.037 0.016 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.048 0.039 -9999.0 0.0 -0.131 7.0 7.0 EXOC4 0.028 0.007 -9999.0 0.0 0.0 37.0 37.0 STX4 -0.048 0.025 0.157 5.0 -9999.0 0.0 5.0 PIP5K1C -0.045 0.028 0.157 5.0 -9999.0 0.0 5.0 LIMA1 0.029 0.006 -9999.0 0.0 0.0 20.0 20.0 ABI1 0.029 0.005 -9999.0 0.0 0.0 14.0 14.0 ROCK1 -0.045 0.075 0.237 11.0 -9999.0 0.0 11.0 adherens junction assembly -0.064 0.104 0.224 1.0 -0.568 15.0 16.0 IGF-1R heterotetramer/IGF1 -0.074 0.042 0.092 3.0 -0.142 131.0 134.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.03 0.042 -9999.0 0.0 -0.163 22.0 22.0 MET 0.025 0.011 -9999.0 0.0 0.0 88.0 88.0 PLEKHA7 -0.048 0.025 0.157 5.0 -9999.0 0.0 5.0 mol:GTP 0.054 0.037 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.043 0.089 0.283 13.0 -9999.0 0.0 13.0 cortical actin cytoskeleton stabilization -0.01 0.057 -9999.0 0.0 -0.198 26.0 26.0 regulation of cell-cell adhesion -0.05 0.028 0.134 5.0 -0.223 1.0 6.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.01 0.058 -9999.0 0.0 -0.199 26.0 26.0