Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.204 0.317 -9999.0 0.0 -1.116 15.0 15.0 IHH -0.423 0.318 -9999.0 0.0 -0.645 119.0 119.0 SHH Np/Cholesterol/GAS1 -0.108 0.228 -9999.0 0.0 -0.442 52.0 52.0 LRPAP1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.108 0.226 0.439 52.0 -9999.0 0.0 52.0 SMO/beta Arrestin2 -0.148 0.234 -9999.0 0.0 -0.753 16.0 16.0 SMO -0.162 0.243 -9999.0 0.0 -0.784 16.0 16.0 AKT1 -0.052 0.111 -9999.0 0.0 -0.85 1.0 1.0 ARRB2 0.012 0.051 -9999.0 0.0 -0.67 1.0 1.0 BOC 0.005 0.088 -9999.0 0.0 -0.67 3.0 3.0 ADRBK1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.16 0.237 -9999.0 0.0 -0.764 16.0 16.0 STIL -0.201 0.25 -9999.0 0.0 -0.6 40.0 40.0 DHH N/PTCH2 -0.072 0.222 -9999.0 0.0 -0.549 30.0 30.0 DHH N/PTCH1 -0.19 0.218 -9999.0 0.0 -0.684 18.0 18.0 PIK3CA 0.012 0.051 -9999.0 0.0 -0.67 1.0 1.0 DHH -0.03 0.172 -9999.0 0.0 -0.669 12.0 12.0 PTHLH -0.195 0.345 -9999.0 0.0 -1.155 16.0 16.0 determination of left/right symmetry -0.16 0.237 -9999.0 0.0 -0.764 16.0 16.0 PIK3R1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.192 0.335 -9999.0 0.0 -1.125 16.0 16.0 IHH N/Hhip -0.301 0.254 -9999.0 0.0 -0.446 124.0 124.0 DHH N/Hhip -0.061 0.213 -9999.0 0.0 -0.556 26.0 26.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.16 0.237 -9999.0 0.0 -0.764 16.0 16.0 pancreas development -0.053 0.206 -9999.0 0.0 -0.666 18.0 18.0 HHAT 0.012 0.051 -9999.0 0.0 -0.67 1.0 1.0 PI3K 0.021 0.039 -9999.0 0.0 -0.494 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.057 0.211 -9999.0 0.0 -0.668 19.0 19.0 somite specification -0.16 0.237 -9999.0 0.0 -0.764 16.0 16.0 SHH Np/Cholesterol/PTCH1 -0.22 0.264 -9999.0 0.0 -0.639 40.0 40.0 SHH Np/Cholesterol/PTCH2 -0.116 0.219 -9999.0 0.0 -0.417 58.0 58.0 SHH Np/Cholesterol/Megalin -0.125 0.221 -9999.0 0.0 -0.422 59.0 59.0 SHH -0.095 0.219 -9999.0 0.0 -0.49 42.0 42.0 catabolic process -0.195 0.204 -9999.0 0.0 -0.666 14.0 14.0 SMO/Vitamin D3 -0.202 0.274 -9999.0 0.0 -0.63 40.0 40.0 SHH Np/Cholesterol/Hhip -0.107 0.212 -9999.0 0.0 -0.412 55.0 55.0 LRP2 -0.079 0.231 -9999.0 0.0 -0.663 24.0 24.0 receptor-mediated endocytosis -0.213 0.27 -9999.0 0.0 -0.765 21.0 21.0 SHH Np/Cholesterol/BOC -0.073 0.186 -9999.0 0.0 -0.395 43.0 43.0 SHH Np/Cholesterol/CDO -0.069 0.174 -9999.0 0.0 -0.377 43.0 43.0 mesenchymal cell differentiation 0.106 0.211 0.409 55.0 -9999.0 0.0 55.0 mol:Vitamin D3 -0.22 0.266 -9999.0 0.0 -0.642 40.0 40.0 IHH N/PTCH2 -0.312 0.262 -9999.0 0.0 -0.456 125.0 125.0 CDON 0.012 0.051 -9999.0 0.0 -0.67 1.0 1.0 IHH N/PTCH1 -0.197 0.207 -9999.0 0.0 -0.676 14.0 14.0 Megalin/LRPAP1 -0.047 0.174 -9999.0 0.0 -0.488 24.0 24.0 PTCH2 -0.068 0.226 -9999.0 0.0 -0.67 22.0 22.0 SHH Np/Cholesterol -0.091 0.164 -9999.0 0.0 -0.386 42.0 42.0 PTCH1 -0.196 0.205 -9999.0 0.0 -0.669 14.0 14.0 HHIP -0.053 0.206 -9999.0 0.0 -0.667 18.0 18.0