Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.092 0.178 -9999.0 0.0 -0.595 15.0 15.0 IHH -0.218 0.199 -9999.0 0.0 -0.365 113.0 113.0 SHH Np/Cholesterol/GAS1 -0.025 0.113 -9999.0 0.0 -0.218 42.0 42.0 LRPAP1 0.037 0.007 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.025 0.112 0.217 42.0 -9999.0 0.0 42.0 SMO/beta Arrestin2 -0.06 0.161 -9999.0 0.0 -0.515 14.0 14.0 SMO -0.071 0.161 -9999.0 0.0 -0.514 15.0 15.0 AKT1 -0.014 0.149 -9999.0 0.0 -0.714 6.0 6.0 ARRB2 0.031 0.033 -9999.0 0.0 -0.372 1.0 1.0 BOC 0.03 0.053 -9999.0 0.0 -0.372 3.0 3.0 ADRBK1 0.037 0.007 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.07 0.158 -9999.0 0.0 -0.505 15.0 15.0 STIL -0.089 0.134 -9999.0 0.0 -0.314 31.0 31.0 DHH N/PTCH2 0.003 0.121 -9999.0 0.0 -0.286 25.0 25.0 DHH N/PTCH1 -0.078 0.131 -9999.0 0.0 -0.387 16.0 16.0 PIK3CA 0.034 0.032 -9999.0 0.0 -0.372 1.0 1.0 DHH 0.019 0.08 -9999.0 0.0 -0.372 7.0 7.0 PTHLH -0.084 0.198 -9999.0 0.0 -0.7 13.0 13.0 determination of left/right symmetry -0.07 0.158 -9999.0 0.0 -0.505 15.0 15.0 PIK3R1 0.036 0.009 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.084 0.195 -9999.0 0.0 -0.692 13.0 13.0 IHH N/Hhip -0.133 0.147 -9999.0 0.0 -0.23 113.0 113.0 DHH N/Hhip 0.018 0.102 -9999.0 0.0 -0.27 19.0 19.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.07 0.158 -9999.0 0.0 -0.505 15.0 15.0 pancreas development 0.004 0.11 -9999.0 0.0 -0.37 14.0 14.0 HHAT 0.036 0.01 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.051 0.025 -9999.0 0.0 -0.223 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.007 0.126 -9999.0 0.0 -0.371 19.0 19.0 somite specification -0.07 0.158 -9999.0 0.0 -0.505 15.0 15.0 SHH Np/Cholesterol/PTCH1 -0.095 0.138 -9999.0 0.0 -0.326 33.0 33.0 SHH Np/Cholesterol/PTCH2 -0.032 0.111 -9999.0 0.0 -0.208 48.0 48.0 SHH Np/Cholesterol/Megalin -0.034 0.111 -9999.0 0.0 -0.208 48.0 48.0 SHH -0.035 0.109 -9999.0 0.0 -0.257 34.0 34.0 catabolic process -0.092 0.132 -9999.0 0.0 -0.421 15.0 15.0 SMO/Vitamin D3 -0.086 0.155 -9999.0 0.0 -0.48 14.0 14.0 SHH Np/Cholesterol/Hhip -0.024 0.108 -9999.0 0.0 -0.211 42.0 42.0 LRP2 -0.018 0.134 -9999.0 0.0 -0.364 23.0 23.0 receptor-mediated endocytosis -0.094 0.157 -9999.0 0.0 -0.476 16.0 16.0 SHH Np/Cholesterol/BOC -0.01 0.091 -9999.0 0.0 -0.193 34.0 34.0 SHH Np/Cholesterol/CDO -0.008 0.089 -9999.0 0.0 -0.192 33.0 33.0 mesenchymal cell differentiation 0.024 0.107 0.21 42.0 -9999.0 0.0 42.0 mol:Vitamin D3 -0.091 0.145 0.227 4.0 -0.327 33.0 37.0 IHH N/PTCH2 -0.144 0.154 -9999.0 0.0 -0.237 119.0 119.0 CDON 0.035 0.031 -9999.0 0.0 -0.372 1.0 1.0 IHH N/PTCH1 -0.09 0.137 -9999.0 0.0 -0.425 15.0 15.0 Megalin/LRPAP1 0.016 0.098 -9999.0 0.0 -0.256 20.0 20.0 PTCH2 -0.012 0.132 -9999.0 0.0 -0.372 21.0 21.0 SHH Np/Cholesterol -0.02 0.084 -9999.0 0.0 -0.192 34.0 34.0 PTCH1 -0.093 0.132 -9999.0 0.0 -0.423 15.0 15.0 HHIP 0.004 0.11 -9999.0 0.0 -0.37 14.0 14.0