Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.034 0.021 -9999.0 0.0 -0.188 1.0 1.0 epithelial cell differentiation 0.072 0.032 -9999.0 0.0 -0.184 1.0 1.0 CYFIP2 0.018 0.085 -9999.0 0.0 -0.372 8.0 8.0 ENAH -0.03 0.071 0.322 2.0 -9999.0 0.0 2.0 EGFR 0.029 0.053 -9999.0 0.0 -0.371 3.0 3.0 EPHA2 -0.082 0.183 -9999.0 0.0 -0.364 52.0 52.0 MYO6 0.023 0.032 0.184 5.0 -9999.0 0.0 5.0 CTNNB1 0.037 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.058 0.064 -9999.0 0.0 -0.218 8.0 8.0 AQP5 -0.108 0.088 -9999.0 0.0 -0.422 6.0 6.0 CTNND1 0.037 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.024 0.031 0.199 4.0 -9999.0 0.0 4.0 regulation of calcium-dependent cell-cell adhesion 0.017 0.057 0.192 7.0 -9999.0 0.0 7.0 EGF -0.07 0.179 -9999.0 0.0 -0.371 46.0 46.0 NCKAP1 0.037 0.005 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 0.014 0.076 -9999.0 0.0 -0.417 4.0 4.0 cortical microtubule organization 0.072 0.032 -9999.0 0.0 -0.184 1.0 1.0 GO:0000145 -0.002 0.032 0.186 4.0 -9999.0 0.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.08 0.034 -9999.0 0.0 -0.185 1.0 1.0 MLLT4 0.034 0.012 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.05 0.067 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.036 0.008 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.007 0.124 -9999.0 0.0 -0.195 45.0 45.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.013 0.026 0.181 1.0 -9999.0 0.0 1.0 PVRL2 0.036 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.021 0.02 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP 0.015 0.123 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.035 0.031 -9999.0 0.0 -0.372 1.0 1.0 EGFR/EGFR/EGF/EGF 0.003 0.107 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GDP 0.075 0.032 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.015 0.03 0.169 5.0 -9999.0 0.0 5.0 IGF-1R heterotetramer 0.037 0.007 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.036 0.008 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.037 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.089 0.188 -9999.0 0.0 -0.372 54.0 54.0 DIAPH1 0.029 0.17 -9999.0 0.0 -0.598 8.0 8.0 Wnt receptor signaling pathway -0.072 0.032 0.184 1.0 -9999.0 0.0 1.0 RHOA 0.037 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.049 0.066 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.036 0.008 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.015 0.031 0.171 5.0 -9999.0 0.0 5.0 EFNA1 0.035 0.011 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.009 0.027 0.175 2.0 -9999.0 0.0 2.0 Ephrin A1/EPHA2 -0.002 0.107 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 0.018 0.017 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 0.017 0.058 0.194 7.0 -9999.0 0.0 7.0 HGF/MET 0.035 0.09 -9999.0 0.0 -0.334 3.0 3.0 HGF 0.001 0.114 -9999.0 0.0 -0.372 15.0 15.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.034 0.022 -9999.0 0.0 -0.189 1.0 1.0 actin cable formation 0.021 0.099 0.295 12.0 -9999.0 0.0 12.0 KIAA1543 -0.002 0.035 0.173 5.0 -9999.0 0.0 5.0 KIFC3 0.023 0.038 0.188 5.0 -9999.0 0.0 5.0 NCK1 0.037 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.037 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.023 0.028 0.2 3.0 -9999.0 0.0 3.0 NCK1/GIT1 0.053 0.014 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.072 0.032 -9999.0 0.0 -0.184 1.0 1.0 EXOC4 0.036 0.009 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.027 0.034 0.187 6.0 -9999.0 0.0 6.0 PIP5K1C 0.024 0.031 0.201 4.0 -9999.0 0.0 4.0 LIMA1 0.036 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.037 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.023 0.091 0.265 6.0 -9999.0 0.0 6.0 adherens junction assembly 0.012 0.064 0.248 5.0 -0.283 2.0 7.0 IGF-1R heterotetramer/IGF1 -0.006 0.111 -9999.0 0.0 -9999.0 0.0 0.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.048 0.02 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.013 0.094 -9999.0 0.0 -0.369 10.0 10.0 PLEKHA7 0.024 0.035 0.188 5.0 -9999.0 0.0 5.0 mol:GTP 0.005 0.122 -9999.0 0.0 -0.194 45.0 45.0 establishment of epithelial cell apical/basal polarity 0.042 0.104 0.511 6.0 -9999.0 0.0 6.0 cortical actin cytoskeleton stabilization 0.034 0.021 -9999.0 0.0 -0.188 1.0 1.0 regulation of cell-cell adhesion 0.015 0.03 0.169 5.0 -9999.0 0.0 5.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.034 0.022 -9999.0 0.0 -0.189 1.0 1.0