Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.056 0.077 -9999.0 0.0 -9999.0 0.0 0.0 IHH 0.025 0.027 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/GAS1 -0.085 0.148 -9999.0 0.0 -0.303 55.0 55.0 LRPAP1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.085 0.147 0.301 55.0 -9999.0 0.0 55.0 SMO/beta Arrestin2 0.006 0.101 -9999.0 0.0 -0.426 1.0 1.0 SMO 0.002 0.106 -9999.0 0.0 -0.449 1.0 1.0 AKT1 0.016 0.057 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.003 0.105 -9999.0 0.0 -0.443 1.0 1.0 STIL -0.029 0.126 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH2 0.011 0.042 -9999.0 0.0 -0.383 2.0 2.0 DHH N/PTCH1 0.046 0.05 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.062 0.094 -9999.0 0.0 -9999.0 0.0 0.0 determination of left/right symmetry 0.003 0.105 -9999.0 0.0 -0.443 1.0 1.0 PIK3R1 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.062 0.094 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/Hhip -0.263 0.211 -9999.0 0.0 -0.418 116.0 116.0 DHH N/Hhip -0.243 0.189 -9999.0 0.0 -0.383 116.0 116.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.003 0.105 -9999.0 0.0 -0.443 1.0 1.0 pancreas development -0.341 0.256 -9999.0 0.0 -0.53 116.0 116.0 HHAT 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.026 0.135 -9999.0 0.0 -0.531 12.0 12.0 somite specification 0.003 0.105 -9999.0 0.0 -0.443 1.0 1.0 SHH Np/Cholesterol/PTCH1 -0.031 0.135 -9999.0 0.0 -0.255 43.0 43.0 SHH Np/Cholesterol/PTCH2 -0.069 0.134 -9999.0 0.0 -0.292 47.0 47.0 SHH Np/Cholesterol/Megalin -0.071 0.13 -9999.0 0.0 -0.295 45.0 45.0 SHH -0.092 0.169 -9999.0 0.0 -0.383 45.0 45.0 catabolic process 0.047 0.062 -9999.0 0.0 -9999.0 0.0 0.0 SMO/Vitamin D3 -0.034 0.14 -9999.0 0.0 -0.42 1.0 1.0 SHH Np/Cholesterol/Hhip -0.26 0.18 -9999.0 0.0 -0.348 135.0 135.0 LRP2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 receptor-mediated endocytosis -0.037 0.137 -9999.0 0.0 -0.39 1.0 1.0 SHH Np/Cholesterol/BOC -0.065 0.132 -9999.0 0.0 -0.292 45.0 45.0 SHH Np/Cholesterol/CDO -0.065 0.132 -9999.0 0.0 -0.292 45.0 45.0 mesenchymal cell differentiation 0.258 0.179 0.346 135.0 -9999.0 0.0 135.0 mol:Vitamin D3 -0.026 0.138 -9999.0 0.0 -0.254 43.0 43.0 IHH N/PTCH2 0.019 0.05 -9999.0 0.0 -0.421 2.0 2.0 CDON 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.052 0.066 0.257 16.0 -9999.0 0.0 16.0 Megalin/LRPAP1 0.008 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.004 0.057 -9999.0 0.0 -0.531 2.0 2.0 SHH Np/Cholesterol -0.069 0.131 -9999.0 0.0 -0.295 45.0 45.0 PTCH1 0.047 0.062 -9999.0 0.0 -9999.0 0.0 0.0 HHIP -0.341 0.257 -9999.0 0.0 -0.531 116.0 116.0