Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
PDGFR-alpha signaling pathway	63.0	2801.0	44.0	-0.316	0.023	1000.0	-1000.0	-0.007	-1000.0
Noncanonical Wnt signaling pathway	52.0	1359.0	26.0	-0.44	0.01	1000.0	-1000.0	-0.019	-1000.0
Wnt signaling	51.0	359.0	7.0	-0.44	0.01	1000.0	-1000.0	-0.017	-1000.0
IL23-mediated signaling events	41.0	2487.0	60.0	-0.649	0.022	1000.0	-1000.0	-0.07	-1000.0
Ras signaling in the CD4+ TCR pathway	39.0	671.0	17.0	-0.377	0.019	1000.0	-1000.0	-0.012	-1000.0
Thromboxane A2 receptor signaling	33.0	3509.0	105.0	-0.323	0.084	1000.0	-1000.0	-0.035	-1000.0
EGFR-dependent Endothelin signaling events	30.0	632.0	21.0	-0.201	0.015	1000.0	-1000.0	-0.015	-1000.0
IGF1 pathway	30.0	1710.0	57.0	-0.153	0.078	1000.0	-1000.0	-0.026	-1000.0
Insulin Pathway	29.0	2165.0	74.0	-0.419	0.067	1000.0	-1000.0	-0.033	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	28.0	1491.0	52.0	-0.331	0.012	1000.0	-1000.0	-0.013	-1000.0
Signaling mediated by p38-alpha and p38-beta	28.0	1253.0	44.0	-0.347	0.01	1000.0	-1000.0	-0.013	-1000.0
mTOR signaling pathway	26.0	1401.0	53.0	-0.199	0.072	1000.0	-1000.0	-0.029	-1000.0
Integrins in angiogenesis	24.0	2083.0	84.0	-0.416	0.026	1000.0	-1000.0	-0.046	-1000.0
Signaling events mediated by the Hedgehog family	23.0	1244.0	52.0	-0.341	0.258	1000.0	-1000.0	-0.017	-1000.0
Syndecan-3-mediated signaling events	22.0	793.0	35.0	-0.277	0.03	1000.0	-1000.0	-0.017	-1000.0
IL6-mediated signaling events	22.0	1681.0	75.0	-0.304	0.027	1000.0	-1000.0	-0.015	-1000.0
HIF-1-alpha transcription factor network	19.0	1461.0	76.0	-0.202	0.059	1000.0	-1000.0	-0.048	-1000.0
amb2 Integrin signaling	19.0	1566.0	82.0	-0.322	0.014	1000.0	-1000.0	-0.022	-1000.0
IL1-mediated signaling events	19.0	1234.0	62.0	-0.317	0.032	1000.0	-1000.0	-0.041	-1000.0
Syndecan-1-mediated signaling events	18.0	622.0	34.0	-0.126	0.01	1000.0	-1000.0	-0.018	-1000.0
Glypican 1 network	18.0	888.0	48.0	-0.386	0.021	1000.0	-1000.0	-0.008	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	16.0	577.0	34.0	-0.076	0.01	1000.0	-1000.0	-0.013	-1000.0
Arf6 signaling events	16.0	1001.0	62.0	-0.253	0.025	1000.0	-1000.0	-0.021	-1000.0
Glucocorticoid receptor regulatory network	16.0	1871.0	114.0	-0.652	0.163	1000.0	-1000.0	-0.033	-1000.0
TCGA08_rtk_signaling	16.0	429.0	26.0	-0.313	0.012	1000.0	-1000.0	-0.008	-1000.0
Plasma membrane estrogen receptor signaling	13.0	1124.0	86.0	-0.18	0.069	1000.0	-1000.0	-0.042	-1000.0
IL12-mediated signaling events	12.0	1101.0	87.0	-0.216	0.026	1000.0	-1000.0	-0.087	-1000.0
Cellular roles of Anthrax toxin	12.0	504.0	39.0	-0.152	0.01	1000.0	-1000.0	-0.014	-1000.0
Signaling events mediated by PTP1B	12.0	913.0	76.0	-0.289	0.037	1000.0	-1000.0	-0.033	-1000.0
FOXA2 and FOXA3 transcription factor networks	12.0	565.0	46.0	-1.077	0.239	1000.0	-1000.0	-0.009	-1000.0
Syndecan-2-mediated signaling events	11.0	772.0	69.0	-0.277	0.024	1000.0	-1000.0	-0.009	-1000.0
HIF-2-alpha transcription factor network	10.0	432.0	43.0	-0.186	0.056	1000.0	-1000.0	-0.046	-1000.0
LPA receptor mediated events	10.0	1080.0	102.0	-0.327	0.094	1000.0	-1000.0	-0.043	-1000.0
BMP receptor signaling	9.0	801.0	81.0	-0.452	0.034	1000.0	-1000.0	-0.047	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	9.0	352.0	37.0	-0.198	0.026	1000.0	-1000.0	-0.015	-1000.0
Retinoic acid receptors-mediated signaling	9.0	569.0	58.0	-0.331	0.036	1000.0	-1000.0	-0.03	-1000.0
Nongenotropic Androgen signaling	9.0	509.0	52.0	-0.078	0.077	1000.0	-1000.0	-0.02	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	9.0	659.0	68.0	-0.346	0.059	1000.0	-1000.0	-0.049	-1000.0
E-cadherin signaling in keratinocytes	9.0	412.0	43.0	-0.201	0.026	1000.0	-1000.0	-0.016	-1000.0
IL4-mediated signaling events	8.0	736.0	91.0	-0.289	0.289	1000.0	-1000.0	-0.103	-1000.0
Syndecan-4-mediated signaling events	8.0	546.0	67.0	-0.14	0.017	1000.0	-1000.0	-0.031	-1000.0
Coregulation of Androgen receptor activity	7.0	533.0	76.0	-0.254	0.04	1000.0	-1000.0	-0.019	-1000.0
Reelin signaling pathway	7.0	405.0	56.0	-0.027	0.263	1000.0	-1000.0	-0.02	-1000.0
Endothelins	7.0	712.0	96.0	-0.134	0.077	1000.0	-1000.0	-0.036	-1000.0
S1P1 pathway	7.0	255.0	36.0	-0.123	0.02	1000.0	-1000.0	-0.033	-1000.0
ErbB4 signaling events	6.0	437.0	69.0	-0.222	0.08	1000.0	-1000.0	-0.035	-1000.0
Nectin adhesion pathway	6.0	405.0	63.0	-0.476	0.03	1000.0	-1000.0	-0.038	-1000.0
TRAIL signaling pathway	6.0	320.0	48.0	-0.087	0.022	1000.0	-1000.0	-0.021	-1000.0
Signaling events regulated by Ret tyrosine kinase	6.0	519.0	82.0	-0.289	0.066	1000.0	-1000.0	-0.04	-1000.0
Calcium signaling in the CD4+ TCR pathway	6.0	208.0	31.0	-0.108	0.01	1000.0	-1000.0	-0.033	-1000.0
Angiopoietin receptor Tie2-mediated signaling	6.0	531.0	88.0	-0.419	0.067	1000.0	-1000.0	-0.057	-1000.0
Regulation of Androgen receptor activity	6.0	425.0	70.0	-0.375	0.044	1000.0	-1000.0	-0.031	-1000.0
Circadian rhythm pathway	5.0	130.0	22.0	-0.136	0.01	1000.0	-1000.0	-0.023	-1000.0
Arf6 downstream pathway	5.0	253.0	43.0	-0.069	0.033	1000.0	-1000.0	-0.018	-1000.0
FoxO family signaling	5.0	322.0	64.0	-0.312	0.04	1000.0	-1000.0	-0.017	-1000.0
FAS signaling pathway (CD95)	5.0	255.0	47.0	-0.353	0.019	1000.0	-1000.0	-0.014	-1000.0
IL2 signaling events mediated by PI3K	5.0	337.0	58.0	-0.119	0.021	1000.0	-1000.0	-0.029	-1000.0
Canonical Wnt signaling pathway	5.0	261.0	51.0	-0.197	0.06	1000.0	-1000.0	-0.031	-1000.0
BCR signaling pathway	5.0	592.0	99.0	-0.177	0.069	1000.0	-1000.0	-0.037	-1000.0
Regulation of nuclear SMAD2/3 signaling	4.0	643.0	136.0	-0.331	0.165	1000.0	-1000.0	-0.022	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	4.0	375.0	85.0	-0.023	0.022	1000.0	-1000.0	-0.019	-1000.0
Fc-epsilon receptor I signaling in mast cells	4.0	418.0	97.0	-0.102	0.027	1000.0	-1000.0	-0.04	-1000.0
Paxillin-dependent events mediated by a4b1	4.0	149.0	36.0	-0.198	0.027	1000.0	-1000.0	-0.014	-1000.0
Effects of Botulinum toxin	4.0	108.0	26.0	-0.0	0.032	1000.0	-1000.0	-0.017	-1000.0
PDGFR-beta signaling pathway	4.0	400.0	97.0	-0.123	0.026	1000.0	-1000.0	-0.038	-1000.0
FOXM1 transcription factor network	4.0	248.0	51.0	-0.072	0.091	1000.0	-1000.0	-0.068	-1000.0
Osteopontin-mediated events	3.0	126.0	38.0	-0.014	0.039	1000.0	-1000.0	-0.015	-1000.0
Presenilin action in Notch and Wnt signaling	3.0	211.0	61.0	-0.204	0.034	1000.0	-1000.0	-0.03	-1000.0
EPO signaling pathway	3.0	175.0	55.0	-0.059	0.042	1000.0	-1000.0	-0.03	-1000.0
Ceramide signaling pathway	3.0	257.0	76.0	-0.144	0.025	1000.0	-1000.0	-0.024	-1000.0
Signaling events mediated by HDAC Class III	3.0	128.0	40.0	-0.141	0.019	1000.0	-1000.0	-0.01	-1000.0
Regulation of p38-alpha and p38-beta	3.0	175.0	54.0	-0.135	0.046	1000.0	-1000.0	-0.028	-1000.0
IL27-mediated signaling events	3.0	187.0	51.0	-0.153	0.024	1000.0	-1000.0	-0.033	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	3.0	240.0	74.0	-0.201	0.031	1000.0	-1000.0	-0.035	-1000.0
Arf6 trafficking events	3.0	276.0	71.0	-0.105	0.048	1000.0	-1000.0	-0.026	-1000.0
S1P3 pathway	3.0	160.0	42.0	-0.086	0.073	1000.0	-1000.0	-0.019	-1000.0
Visual signal transduction: Rods	3.0	206.0	52.0	-0.051	0.05	1000.0	-1000.0	-0.029	-1000.0
ErbB2/ErbB3 signaling events	2.0	175.0	65.0	-0.014	0.053	1000.0	-1000.0	-0.028	-1000.0
Sphingosine 1-phosphate (S1P) pathway	2.0	71.0	28.0	-0.087	0.027	1000.0	-1000.0	-0.019	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	2.0	108.0	54.0	-0.027	0.079	1000.0	-1000.0	-0.047	-1000.0
Hedgehog signaling events mediated by Gli proteins	2.0	165.0	65.0	-0.038	0.064	1000.0	-1000.0	-0.029	-1000.0
p75(NTR)-mediated signaling	2.0	347.0	125.0	-0.013	0.03	1000.0	-1000.0	-0.046	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	197.0	83.0	-0.144	0.059	1000.0	-1000.0	-0.026	-1000.0
Signaling mediated by p38-gamma and p38-delta	2.0	36.0	15.0	-0.004	0.078	1000.0	-1000.0	-0.009	-1000.0
TCR signaling in naïve CD8+ T cells	2.0	197.0	93.0	-0.013	0.029	1000.0	-1000.0	-0.039	-1000.0
EPHB forward signaling	2.0	190.0	85.0	-0.06	0.07	1000.0	-1000.0	-0.041	-1000.0
Class I PI3K signaling events	2.0	166.0	73.0	-0.145	0.03	1000.0	-1000.0	-0.018	-1000.0
Regulation of Telomerase	2.0	246.0	102.0	-0.201	0.029	1000.0	-1000.0	-0.051	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	2.0	85.0	33.0	-0.114	0.031	1000.0	-1000.0	-0.022	-1000.0
Rapid glucocorticoid signaling	2.0	43.0	20.0	-0.0	0.032	1000.0	-1000.0	-0.004	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	2.0	267.0	120.0	-0.098	0.094	1000.0	-1000.0	-0.034	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	2.0	233.0	78.0	-0.068	0.052	1000.0	-1000.0	-0.032	-1000.0
p38 MAPK signaling pathway	2.0	102.0	44.0	-0.068	0.044	1000.0	-1000.0	-0.028	-1000.0
LPA4-mediated signaling events	1.0	14.0	12.0	0.0	0.019	1000.0	-1000.0	-0.004	-1000.0
Caspase cascade in apoptosis	1.0	93.0	74.0	-0.175	0.031	1000.0	-1000.0	-0.024	-1000.0
JNK signaling in the CD4+ TCR pathway	1.0	23.0	17.0	-0.005	0.025	1000.0	-1000.0	-0.018	-1000.0
Insulin-mediated glucose transport	1.0	54.0	32.0	-0.027	0.021	1000.0	-1000.0	-0.026	-1000.0
IFN-gamma pathway	1.0	78.0	68.0	-0.057	0.075	1000.0	-1000.0	-0.051	-1000.0
Class I PI3K signaling events mediated by Akt	1.0	134.0	68.0	-0.07	0.029	1000.0	-1000.0	-0.021	-1000.0
Ephrin B reverse signaling	1.0	90.0	48.0	-0.056	0.025	1000.0	-1000.0	-0.015	-1000.0
IL2 signaling events mediated by STAT5	1.0	34.0	22.0	-0.027	0.03	1000.0	-1000.0	-0.009	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	8.0	23.0	-0.002	0.027	1000.0	-1000.0	-0.02	-1000.0
Canonical NF-kappaB pathway	0.0	10.0	39.0	-0.002	0.038	1000.0	-1000.0	-0.027	-1000.0
Signaling events mediated by HDAC Class II	0.0	20.0	75.0	-0.018	0.05	1000.0	-1000.0	-0.018	-1000.0
BARD1 signaling events	0.0	0.0	57.0	-0.025	0.034	1000.0	-1000.0	-0.023	-1000.0
PLK2 and PLK4 events	0.0	0.0	3.0	0.01	0.012	1000.0	-1000.0	-0.004	-1000.0
Visual signal transduction: Cones	0.0	35.0	38.0	-0.008	0.018	1000.0	-1000.0	-0.009	-1000.0
Ephrin A  reverse signaling	0.0	0.0	7.0	-0.0	0.053	1000.0	-1000.0	-0.005	-1000.0
a4b1 and a4b7 Integrin signaling	0.0	2.0	5.0	0.007	0.015	1000.0	-1000.0	-0.004	-1000.0
Aurora A signaling	0.0	0.0	60.0	-0.001	0.027	1000.0	-1000.0	-0.016	-1000.0
Aurora C signaling	0.0	2.0	7.0	-0.0	0.018	1000.0	-1000.0	-0.01	-1000.0
PLK1 signaling events	0.0	2.0	85.0	-0.006	0.032	1000.0	-1000.0	-0.02	-1000.0
S1P5 pathway	0.0	1.0	17.0	-0.001	0.014	1000.0	-1000.0	-0.012	-1000.0
ceramide signaling pathway	0.0	14.0	49.0	0.0	0.029	1000.0	-1000.0	-0.024	-1000.0
Signaling events mediated by HDAC Class I	0.0	15.0	104.0	-0.02	0.031	1000.0	-1000.0	-0.02	-1000.0
TCGA08_p53	0.0	0.0	7.0	-0.0	0.01	1000.0	-1000.0	-0.004	-1000.0
Atypical NF-kappaB pathway	0.0	0.0	31.0	-0.0	0.028	1000.0	-1000.0	-0.012	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	0.0	36.0	45.0	-0.008	0.03	1000.0	-1000.0	-0.048	-1000.0
Glypican 2 network	0.0	0.0	4.0	0.01	0.015	1000.0	-1000.0	-0.003	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	0.0	14.0	125.0	-0.008	0.046	1000.0	-1000.0	-0.042	-1000.0
E-cadherin signaling in the nascent adherens junction	0.0	7.0	76.0	-0.0	0.03	1000.0	-1000.0	-0.039	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	0.0	27.0	0.0	0.026	1000.0	-1000.0	-0.025	-1000.0
TCGA08_retinoblastoma	0.0	4.0	8.0	-0.009	0.01	1000.0	-1000.0	-0.005	-1000.0
VEGFR1 specific signals	0.0	7.0	56.0	0.0	0.042	1000.0	-1000.0	-0.018	-1000.0
Signaling events mediated by PRL	0.0	14.0	34.0	-0.002	0.026	1000.0	-1000.0	-0.01	-1000.0
Class IB PI3K non-lipid kinase events	0.0	0.0	3.0	-0.01	0.01	1000.0	-1000.0	-0.003	-1000.0
S1P4 pathway	0.0	4.0	25.0	-0.0	0.018	1000.0	-1000.0	-0.017	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	0.007	0.018	1000.0	-1000.0	-0.008	-1000.0
Arf1 pathway	0.0	0.0	54.0	-0.0	0.021	1000.0	-1000.0	-0.011	-1000.0
Alternative NF-kappaB pathway	0.0	5.0	13.0	-0.0	0.028	1000.0	-1000.0	-0.009	-1000.0
Aurora B signaling	0.0	39.0	67.0	-0.101	0.038	1000.0	-1000.0	-0.021	-1000.0
Total	1066	61132	7203	-20.6381573038	5.86930713203	131000	-131000	-3.34832354416	-131000