Clinical Features CN_CNMF METHLYATION_CNMF RPPA_CNMF RPPA_CHIERARCHICAL MRNASEQ_CNMF MRNASEQ_CHIERARCHICAL MIRSEQ_CNMF MIRSEQ_CHIERARCHICAL MIRSEQ_MATURE_CNMF MIRSEQ_MATURE_CHIERARCHICAL nMutated (%) nWild-Type Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q SPOP 57 (11%) 441 9.9999e-06 0.00055 9.9999e-06 0.00055 0.090599 0.48 0.88599 1 9.9999e-06 0.00055 9.9999e-06 0.00055 0.16267 0.582 0.16087 0.58 0.12159 0.51 0.33575 0.728 TP53 57 (11%) 441 9.9999e-06 0.00055 0.00436 0.103 0.00174 0.0547 0.056319 0.435 0.00234 0.0606 5e-05 0.00244 0.071059 0.447 0.0073099 0.128 0.01926 0.208 0.061129 0.447 PTEN 17 (3%) 481 0.53605 0.88 0.52311 0.879 0.35101 0.75 0.49471 0.86 0.01206 0.156 0.00113 0.041 0.54135 0.88 0.13001 0.523 0.67473 0.916 0.88231 1 NUDT11 11 (2%) 487 0.53384 0.88 0.90424 1 0.11935 0.51 0.088449 0.475 0.85096 1 0.92771 1 0.43629 0.813 0.51421 0.874 0.68526 0.924 0.51169 0.873 MLL2 29 (6%) 469 0.070119 0.447 0.096199 0.489 0.29653 0.712 0.48806 0.86 0.02629 0.257 0.0084799 0.138 0.30238 0.712 0.41887 0.805 0.0047 0.103 0.33505 0.728 CTNNB1 13 (3%) 485 0.18526 0.62 0.01016 0.142 0.10083 0.493 0.01206 0.156 0.065469 0.447 0.2066 0.658 0.065109 0.447 0.0075699 0.128 0.02088 0.209 0.11202 0.51 PIK3CA 14 (3%) 484 0.081059 0.466 0.01287 0.156 0.063659 0.447 0.58584 0.892 0.00466 0.103 0.0070399 0.128 0.0416 0.352 0.01031 0.142 0.54843 0.88 0.15679 0.57 KDM6A 13 (3%) 485 0.49989 0.863 0.0201 0.209 0.49439 0.86 0.70456 0.937 0.0099799 0.142 0.0087599 0.138 0.080399 0.466 0.26389 0.682 0.30322 0.712 0.43597 0.813 FOXA1 28 (6%) 470 0.00099999 0.041 9.9999e-06 0.00055 0.0061999 0.128 0.078539 0.466 9.9999e-06 0.00055 9.9999e-06 0.00055 0.097729 0.489 0.0066299 0.128 0.1906 0.631 0.23913 0.666 MLL3 29 (6%) 469 0.03942 0.34 0.30161 0.712 0.79598 1 0.0073199 0.128 0.75379 0.981 0.70983 0.941 0.23933 0.666 0.38294 0.787 0.31215 0.712 0.01809 0.204 GAGE2A 5 (1%) 493 0.52261 0.879 0.66277 0.915 NA NA NA NA 0.68305 0.924 0.45765 0.833 0.85883 1 0.58859 0.893 0.12515 0.519 0.28033 0.705 TNRC18 9 (2%) 489 0.32657 0.726 0.26513 0.682 0.56877 0.881 0.30692 0.712 0.66523 0.915 0.57171 0.881 0.41688 0.805 0.21027 0.658 0.50941 0.872 0.94372 1 AGAP6 5 (1%) 493 1 1 0.65923 0.915 0.48122 0.86 0.2488 0.673 0.22147 0.658 0.45841 0.833 0.74011 0.969 0.30733 0.712 0.41368 0.805 1 1 IDH1 6 (1%) 492 0.88727 1 0.01261 0.156 0.41835 0.805 0.33799 0.729 0.072119 0.447 0.01001 0.142 0.2791 0.705 0.11057 0.51 0.72918 0.961 0.20645 0.658 GATA6 4 (1%) 494 0.91706 1 0.53735 0.88 NA NA NA NA 0.6571 0.915 0.82697 1 1 1 0.68907 0.924 0.62315 0.909 0.8844 1 SMG7 8 (2%) 490 0.03223 0.295 0.074059 0.453 0.54859 0.88 0.73312 0.963 0.01315 0.156 0.00218 0.0599 0.29659 0.712 0.087099 0.473 1 1 0.22809 0.658 CNTNAP1 9 (2%) 489 0.2218 0.658 0.16974 0.59 0.82585 1 1 1 0.5176 0.876 0.70107 0.935 0.9263 1 0.068719 0.447 0.84072 1 0.62642 0.909 CDKN1B 6 (1%) 492 0.31044 0.712 0.11718 0.51 0.10322 0.499 0.01727 0.2 0.56191 0.88 0.095769 0.489 0.28051 0.705 0.11158 0.51 0.28431 0.711 0.84022 1 EOMES 5 (1%) 493 0.25096 0.673 0.42935 0.813 0.66994 0.916 0.11455 0.51 0.93316 1 0.13552 0.527 0.41065 0.805 0.80349 1 0.31206 0.712 0.49025 0.86 NBPF1 9 (2%) 489 0.96674 1 0.10919 0.51 0.85443 1 0.77317 0.995 0.43286 0.813 0.42522 0.81 0.5601 0.88 0.34036 0.731 0.61856 0.909 0.36656 0.77 LMOD2 6 (1%) 492 0.4724 0.852 0.94567 1 0.67141 0.916 0.23167 0.658 0.39516 0.794 0.33096 0.728 0.29579 0.712 0.65011 0.914 0.94608 1 0.9661 1 EHHADH 5 (1%) 493 0.64112 0.914 0.81693 1 0.15343 0.563 0.88961 1 0.64825 0.914 1 1 0.47038 0.852 0.48554 0.86 NA NA NA NA MED12 8 (2%) 490 1 1 0.55406 0.88 0.98405 1 0.8965 1 0.96367 1 0.22308 0.658 0.84709 1 0.88707 1 0.57427 0.881 0.79989 1 ZNF709 5 (1%) 493 0.92289 1 0.25407 0.673 0.11484 0.51 0.096989 0.489 0.64783 0.914 0.54299 0.88 0.11975 0.51 0.25341 0.673 0.32972 0.728 0.31748 0.713 TCEB3 4 (1%) 494 0.83808 1 0.49398 0.86 0.2926 0.712 0.55229 0.88 0.20555 0.658 0.03421 0.301 0.90243 1 0.17416 0.599 0.38642 0.791 0.27951 0.705 MED15 7 (1%) 491 0.084429 0.468 0.14856 0.554 0.39677 0.794 0.57719 0.882 0.83736 1 0.22979 0.658 0.7876 1 0.65348 0.915 0.81258 1 0.80648 1 ERF 5 (1%) 493 1 1 0.22149 0.658 0.57332 0.881 0.060119 0.447 0.4054 0.803 0.63032 0.909 0.79786 1 0.12744 0.523 0.62911 0.909 0.69898 0.935 ERN1 4 (1%) 494 0.36728 0.77 0.01939 0.208 NA NA NA NA 0.2297 0.658 0.55863 0.88 0.30202 0.712 0.79871 1 0.064199 0.447 0.13201 0.523 MLLT10 5 (1%) 493 0.16493 0.585 0.45032 0.833 0.76591 0.992 0.66024 0.915 1 1 0.62681 0.909 0.68643 0.924 0.59071 0.893 NA NA NA NA ZFHX3 16 (3%) 482 0.39711 0.794 0.17031 0.59 0.081539 0.466 0.77186 0.995 0.19493 0.64 0.10636 0.509 0.02053 0.209 0.31583 0.713 0.38136 0.787 0.9613 1 ZMYM3 12 (2%) 486 0.33549 0.728 0.00121 0.041 0.45222 0.833 0.051269 0.403 0.084349 0.468 0.14578 0.548 0.04548 0.371 0.63319 0.91 0.24581 0.673 0.2538 0.673 FMN1 4 (1%) 494 0.53936 0.88 0.19766 0.644 0.5689 0.881 0.61999 0.909 0.2275 0.658 1 1 0.82079 1 0.18562 0.62 NA NA NA NA AKT1 3 (1%) 495 1 1 0.03389 0.301 NA NA NA NA 0.36724 0.77 0.1802 0.615 0.6492 0.914 1 1 NA NA NA NA ATM 22 (4%) 476 0.071239 0.447 0.25748 0.674 0.82842 1 0.82669 1 0.29292 0.712 0.02929 0.274 0.29576 0.712 0.22944 0.658 0.66315 0.915 0.47945 0.86 STRC 5 (1%) 493 0.64026 0.914 0.0484 0.387 NA NA NA NA 0.54667 0.88 0.24765 0.673 0.13743 0.527 0.068669 0.447 NA NA NA NA APC 10 (2%) 488 0.43512 0.813 0.23013 0.658 0.37316 0.778 1 1 0.071159 0.447 0.14241 0.54 0.3195 0.714 0.31769 0.713 0.52642 0.88 0.36011 0.765 ZFP36L2 4 (1%) 494 0.54204 0.88 0.37957 0.787 0.091999 0.482 0.88999 1 0.23033 0.658 0.55748 0.88 1 1 0.21577 0.658 0.50036 0.863 0.59549 0.896 MYOT 5 (1%) 493 0.40989 0.805 0.02907 0.274 0.60569 0.897 0.11917 0.51 0.060229 0.447 0.30055 0.712 0.13523 0.527 0.12849 0.523 0.67256 0.916 0.42348 0.81 KIRREL 6 (1%) 492 0.099709 0.493 0.39463 0.794 0.86588 1 0.085159 0.468 0.56178 0.88 0.50889 0.872 0.59744 0.896 0.60557 0.897 0.72874 0.961 0.88254 1 PGBD2 3 (1%) 495 0.25731 0.674 0.18599 0.62 NA NA NA NA 0.12084 0.51 0.25091 0.673 0.74358 0.971 0.2153 0.658 0.62779 0.909 0.59896 0.896 LOC100132247 3 (1%) 495 0.30874 0.712 1 1 NA NA NA NA 1 1 1 1 1 1 0.90424 1 NA NA NA NA EMG1 4 (1%) 494 0.49472 0.86 0.115 0.51 NA NA NA NA 0.40519 0.803 0.22219 0.658 0.0443 0.368 0.0011 0.041 NA NA NA NA CDH16 4 (1%) 494 0.45176 0.833 0.41749 0.805 0.76622 0.992 0.13174 0.523 0.13773 0.527 0.45427 0.833 0.23402 0.66 0.22107 0.658 0.38941 0.793 0.5536 0.88 KRT25 6 (1%) 492 0.60356 0.897 0.080349 0.466 0.84138 1 0.57438 0.881 0.15222 0.563 0.87475 1 0.26155 0.681 0.00194 0.0569 0.64928 0.914 0.16696 0.588