rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(4), CYP2C9(3) 1500904 7 6 7 0 3 1 1 2 0 0 0.146 0.00364 1.000 2 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 12 AKT1(3), CAT(2), GH1(3), GHR(1), HRAS(4), IGF1R(4), PIK3R1(2), SHC1(3), SOD2(1), SOD3(1) 8207519 24 23 21 2 6 4 6 5 3 0 0.0200 0.00402 1.000 3 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ3(2), COQ5(3), COQ7(1), NDUFA12(1), NDUFA13(2) 2929137 9 8 9 1 2 3 3 0 1 0 0.120 0.0125 1.000 4 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(2), AASDHPPT(1), AASS(3), KARS(2) 3479933 8 8 8 1 0 2 2 3 1 0 0.307 0.0228 1.000 5 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(2), ECHS1(1), EHHADH(5), SDS(1) 3557117 9 9 9 1 3 2 0 3 1 0 0.209 0.0233 1.000 6 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(2), AASDH(2), AASDHPPT(1), AASS(3), KARS(2) 5143805 10 10 10 1 0 2 2 4 2 0 0.264 0.0262 1.000 7 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(2), ECHS1(1), EHHADH(5), HADH(3), HSD17B4(3), SIRT1(3), SIRT2(1), SIRT5(1), VNN2(1) 8706167 20 18 20 2 8 4 1 5 2 0 0.0423 0.0268 1.000 8 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(4), CDC25B(5), CDK7(2), CDKN1A(2), NEK1(3), WEE1(1) 5092069 17 13 17 2 8 2 0 2 5 0 0.193 0.110 1.000 9 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(2), GPD2(1), SDHA(3), SDHB(2), SDHC(2), UQCRC1(2) 4880809 12 9 12 0 0 5 1 2 4 0 0.0186 0.116 1.000 10 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(2), ANKRD1(1), ATF3(1), CYR61(1), DUSP14(1), EIF4E(1), IFRD1(1), IL1A(1), JUND(2), NR4A3(5), WDR1(1) 7921832 17 12 17 1 2 6 4 4 1 0 0.0187 0.122 1.000 11 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(5), GAD1(2), HDC(2), PNMT(1), TPH1(1) 4435557 11 11 11 2 6 1 2 2 0 0 0.182 0.159 1.000 12 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 13 AKT1(3), CASP9(1), GH1(3), GHR(1), NFKB1(3), PDPK1(1), PIK3R1(2), PPP2CA(2), RELA(3) 8766511 19 14 18 1 3 8 1 5 2 0 0.0158 0.172 1.000 13 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(1), ECHS1(1), HADH(3), HADHB(1), HSD17B4(3), MECR(1), PPT2(2) 6224096 12 12 12 2 6 3 0 1 2 0 0.150 0.184 1.000 14 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(2), IL12A(1), IL12B(1) 2214277 4 4 4 1 1 0 0 2 1 0 0.623 0.199 1.000 15 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(1), CYP2E1(1), NR1I3(2), PTGS1(2), PTGS2(5) 3960371 11 9 11 2 4 3 0 2 2 0 0.227 0.222 1.000 16 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(1), IARS(2), LARS(3), LARS2(2), PDHA1(1), PDHA2(4) 7394774 13 11 12 0 1 4 1 5 2 0 0.0215 0.227 1.000 17 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(4), CTH(2), GOT1(2), GOT2(1), LDHB(1), LDHC(1), MPST(1) 5063710 12 8 12 0 5 3 2 1 1 0 0.0175 0.250 1.000 18 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNH(1), CDC25A(4), CDC25B(5), CDK7(2), SHH(2) 6419181 14 12 14 2 6 1 2 2 3 0 0.165 0.258 1.000 19 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(3), SEC61A2(1), SRP19(1), SRP54(2) 5589755 7 7 6 0 0 2 1 2 2 0 0.151 0.276 1.000 20 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(3), ENO2(1), ENO3(1), FARS2(2), GOT1(2), GOT2(1), PAH(1), YARS(3) 6124126 14 9 14 1 7 4 1 1 1 0 0.0298 0.288 1.000 21 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(1), MTMR2(4), MTMR6(1), NFS1(1), THTPA(3) 4716616 10 9 10 2 3 1 3 1 2 0 0.283 0.324 1.000 22 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(1) 377474 1 1 1 0 0 0 0 0 1 0 0.607 0.325 1.000 23 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCL11(1), CCR3(1), CD4(1), HLA-DRA(1), IL4(1), IL6(1) 3947339 6 6 6 1 3 1 0 1 1 0 0.398 0.333 1.000 24 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(2), ALDH1A2(4) 2881639 6 5 5 1 2 0 1 2 1 0 0.480 0.359 1.000 25 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(1), LIPT1(1) 1135539 2 2 2 0 0 2 0 0 0 0 0.516 0.360 1.000 26 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(1), PGLYRP2(3) 1332809 4 4 4 2 0 1 0 2 1 0 0.808 0.364 1.000 27 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(2), ACAT2(1), ECHS1(1), EHHADH(5), GCDH(1), SDHB(2), SDS(1) 5756404 13 10 13 2 5 4 0 3 1 0 0.149 0.366 1.000 28 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(1), ADH1B(1), ADH4(1), ADH6(3), ADHFE1(1) 4184643 7 6 7 1 2 1 1 2 1 0 0.243 0.369 1.000 29 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(2), ACAA2(1), ACAT1(2), ACAT2(1), ECHS1(1), EHHADH(5), HADHB(1), SDS(1) 6177211 14 13 14 3 5 2 1 4 2 0 0.321 0.373 1.000 30 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCL11(1), CCR3(1), HLA-DRA(1) 2240263 3 3 3 0 2 0 0 0 1 0 0.472 0.388 1.000 31 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(1), NFYC(3), RB1(3), SP1(2), SP3(3) 4947836 12 11 12 3 2 2 1 2 4 1 0.498 0.393 1.000 32 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 17 AKT1(3), EIF2B5(1), EIF2S1(1), EIF4E(1), GSK3B(1), IGF1R(4), INPPL1(1), PDK2(1), PDPK1(1), PIK3R1(2), PPP2CA(2), RPS6(1) 12282026 19 18 18 2 2 5 3 6 3 0 0.0634 0.398 1.000 33 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(1) 843933 1 1 1 1 0 1 0 0 0 0 0.872 0.413 1.000 34 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(1), ACP5(1), ACPP(1), ACPT(3), ENPP1(3), ENPP3(2), RFK(1), TYR(2) 7172277 14 14 13 3 3 3 1 3 4 0 0.326 0.419 1.000 35 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 7 CDC25A(4), CDC25B(5), MYT1(2), WEE1(1) 5514447 12 8 12 1 6 2 0 2 2 0 0.118 0.421 1.000 36 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(3), SUCLA2(1) 1555761 4 3 4 0 1 0 0 1 2 0 0.365 0.422 1.000 37 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CASP8(1), CFL1(1), CFLAR(2), PDE6D(1) 2860952 5 4 5 1 2 2 0 0 1 0 0.430 0.438 1.000 38 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(2), GABRA3(1), GABRA4(2), GABRA5(2), GABRA6(2), GPHN(2), UBQLN1(2) 8799202 13 11 13 0 2 3 1 5 2 0 0.0157 0.449 1.000 39 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 17 ABCB1(8), AKT1(3), CDKN1A(2), CPB2(1), HIC1(4), HIF1A(2), IGFBP3(1), MDM2(1), NFKBIB(2), NQO1(2) 10071170 26 19 25 4 11 7 1 4 3 0 0.0501 0.459 1.000 40 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(1), HGD(1) 1657943 2 2 2 0 0 0 0 0 2 0 0.475 0.465 1.000 41 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(2), GOT2(1) 1922079 3 3 3 0 1 1 0 1 0 0 0.367 0.471 1.000 42 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(2), PAPSS2(1), SULT1E1(2), SUOX(1) 4518184 6 6 6 0 3 1 0 1 1 0 0.208 0.486 1.000 43 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 HDAC1(1), MYC(1), SP1(2), SP3(3), WT1(2) 4594936 9 7 9 2 0 1 1 4 3 0 0.468 0.487 1.000 44 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADS(2), ACAT1(2), ECHS1(1) 3997511 5 5 4 1 4 0 0 1 0 0 0.409 0.499 1.000 45 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(2), PARK2(4), SNCAIP(3), UBE2F(1), UBE2L3(1) 4754453 11 8 11 2 3 2 1 5 0 0 0.258 0.505 1.000 46 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALT(1), UGDH(2), UGP2(1) 3623055 4 4 4 1 1 0 1 2 0 0 0.630 0.511 1.000 47 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(2), CD28(2), CD3D(1), CD4(1) 2377872 6 3 6 1 0 2 1 2 1 0 0.352 0.516 1.000 48 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALT(1), UGDH(2) 2842939 3 3 3 1 1 0 1 1 0 0 0.708 0.551 1.000 49 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(2), ACAT2(1), HMGCL(1), OXCT1(5) 2509642 9 5 9 2 2 2 2 3 0 0 0.415 0.566 1.000 50 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), AKR1D1(1), CYP11A1(1), CYP11B1(1), CYP11B2(2), CYP17A1(1), CYP21A2(1), HSD11B1(1), HSD3B1(2), HSD3B2(2) 6759170 13 10 13 2 3 3 1 3 3 0 0.150 0.570 1.000 51 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), AKR1D1(1), CYP11A1(1), CYP11B1(1), CYP11B2(2), CYP17A1(1), CYP21A2(1), HSD11B1(1), HSD3B1(2), HSD3B2(2) 6759170 13 10 13 2 3 3 1 3 3 0 0.150 0.570 1.000 52 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(2), CD4(1), HLA-DRA(1) 1746358 4 2 4 0 1 0 1 1 1 0 0.355 0.585 1.000 53 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(1), F13B(3), HSD17B2(1), HSD17B3(1), HSD17B4(3), HSD17B7(2), HSD3B1(2), HSD3B2(2) 5979653 15 12 14 5 2 4 2 3 3 1 0.530 0.604 1.000 54 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 16 AKT1(3), CREB1(1), GRB2(1), HRAS(4), MAPK1(1), MEF2A(1), MEF2C(3), MEF2D(1), NTRK1(9), PIK3R1(2), PLCG1(1), RPS6KA1(2), SHC1(3) 12296761 32 26 29 5 17 7 5 1 2 0 0.0188 0.610 1.000 55 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC2(3), AOC3(1), CES1(3) 4423346 7 5 7 1 1 2 0 4 0 0 0.347 0.614 1.000 56 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(4), CARS2(2), CTH(2), GOT1(2), GOT2(1), LDHAL6A(1), LDHB(1), LDHC(1), MPST(1), SDS(1), SULT4A1(1) 9256352 17 12 17 2 7 4 2 2 2 0 0.0614 0.614 1.000 57 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ERBB4(4), NRG2(4), NRG3(3), PRKCA(2) 6653203 13 12 13 4 5 2 2 2 2 0 0.448 0.614 1.000 58 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(4), MMP14(1), MMP9(5) 5517903 10 9 8 3 4 0 4 2 0 0 0.427 0.633 1.000 59 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA3(1), GABRA4(2), GABRA5(2), GABRA6(2), PRKCE(2) 5835478 9 7 9 0 2 1 2 3 1 0 0.0506 0.633 1.000 60 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(1), LPL(1), PPARG(1), RXRA(2), TNF(1) 4289930 6 5 6 1 2 0 2 1 1 0 0.367 0.637 1.000 61 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(2), BMPR1A(2), BMPR1B(2), BMPR2(3) 4610072 9 6 9 2 1 1 1 4 2 0 0.628 0.638 1.000 62 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 19 AKT1(3), EIF4A1(1), EIF4B(2), EIF4E(1), EIF4G1(4), EIF4G2(1), EIF4G3(6), PDK2(1), PDPK1(1), PIK3R1(2), PPP2CA(2), RPS6(1), TSC1(2), TSC2(7) 18142356 34 25 33 3 10 5 1 11 7 0 0.0104 0.651 1.000 63 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 14 ABL1(5), CDKN2A(1), E2F1(3), MDM2(1), MYC(1), PIK3R1(2), POLR1A(3), POLR1B(3), POLR1C(2), RAC1(1), RB1(3) 12781807 25 16 25 2 6 2 3 6 7 1 0.0438 0.656 1.000 64 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 DCN(2), FMOD(1), KERA(2) 2654832 5 5 5 2 1 0 0 3 1 0 0.869 0.670 1.000 65 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRNA1(1), SNAP25(1), STX1A(1) 2402720 3 3 3 1 2 1 0 0 0 0 0.585 0.687 1.000 66 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 DHRS1(1), DHRS7(1), DHRSX(5), PON1(1), PON2(3), PON3(1), RDH12(1) 6628567 13 8 13 1 7 0 2 3 1 0 0.0564 0.690 1.000 67 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(2), CBS(1), CTH(2), MARS2(1), MAT1A(3), PAPSS2(1), SEPHS1(1) 9104189 11 9 11 1 3 3 1 1 3 0 0.114 0.706 1.000 68 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(1), DAG1(2), ITPKB(2) 4444274 5 5 5 1 2 1 0 2 0 0 0.427 0.709 1.000 69 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(2), CSF1(1), IL6(1), LDLR(3), LPL(1) 3937715 8 7 8 3 3 2 0 2 1 0 0.490 0.732 1.000 70 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(2) 1214627 2 1 2 1 0 1 1 0 0 0 0.755 0.757 1.000 71 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 B3GALT2(2), B3GALT5(3), B3GNT5(1), FUT1(1), FUT2(1), FUT3(2), ST3GAL3(1) 5333690 11 9 11 3 2 2 2 5 0 0 0.494 0.770 1.000 72 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 11 AKT1(3), GRB2(1), HRAS(4), KLK2(1), NTRK1(9), PIK3R1(2), PLCG1(1), PRKCA(2), SHC1(3), SOS1(4) 9877235 30 23 27 6 14 6 3 2 5 0 0.0844 0.803 1.000 73 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(2), ACOX3(1), FADS2(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(4), PLA2G5(1), PLA2G6(2) 7439179 13 9 13 2 2 1 1 4 5 0 0.242 0.813 1.000 74 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(2), HS3ST3A1(1), XYLT1(6), XYLT2(1) 4737589 10 10 10 3 4 3 0 1 2 0 0.306 0.815 1.000 75 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(2), HS3ST3A1(1), XYLT1(6), XYLT2(1) 4737589 10 10 10 3 4 3 0 1 2 0 0.306 0.815 1.000 76 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 11 CUL1(2), E2F1(3), RB1(3), TFDP1(2) 6026497 10 7 10 3 4 0 2 0 3 1 0.516 0.821 1.000 77 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 GNB1(1), GNGT1(1), HTR2C(3), PLCB1(3), TUB(2) 5294439 10 9 10 3 4 2 1 3 0 0 0.485 0.823 1.000 78 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CDC34(1), CUL1(2), E2F1(3), RB1(3), TFDP1(2) 6100856 11 7 11 3 4 0 2 0 4 1 0.426 0.825 1.000 79 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(4), EIF2AK4(3), EIF2B5(1), EIF2S1(1), EIF5(2), GSK3B(1), PPP1CA(1) 8541990 13 12 13 3 4 0 3 4 2 0 0.328 0.826 1.000 80 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 14 CD4(1), CD8A(1), CSF1(1), IL4(1), IL6(1), IL7(2), IL9(2) 4406485 9 7 9 3 1 1 1 2 4 0 0.672 0.830 1.000 81 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(1), ACP5(1), ACPP(1), ACPT(3), ALPI(1), ALPP(2), ALPPL2(2), CYP19A1(2), CYP1A1(1), CYP1A2(1), CYP2A13(3), CYP2A6(3), CYP2A7(2), CYP2B6(3), CYP2C18(2), CYP2C19(4), CYP2C8(4), CYP2C9(3), CYP2E1(1), CYP2F1(2), CYP2J2(1), CYP3A7(1), CYP4B1(1), PON1(1) 21608147 46 37 45 8 18 5 6 10 7 0 0.0405 0.835 1.000 82 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(1), ABCC2(1), ABCG2(3), BCHE(3), CES1(3), CES2(2), UGT1A1(2), UGT1A10(1), UGT1A4(1), UGT1A7(2), UGT1A9(2) 16898592 21 14 21 0 7 2 1 7 4 0 0.00214 0.838 1.000 83 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(2), FARSB(2), GOT1(2), GOT2(1), PAH(1), YARS(3), YARS2(3) 6409898 14 10 14 3 7 4 1 1 1 0 0.172 0.841 1.000 84 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(2), CD4(1), HLA-DRA(1), IL10(1), IL4(1) 2928620 6 4 6 2 3 0 1 1 1 0 0.569 0.842 1.000 85 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP2(8) 6226633 8 5 8 1 0 2 1 1 4 0 0.454 0.843 1.000 86 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(1), CDC34(1), CUL1(2), E2F1(3), RB1(3), TFDP1(2) 6296235 12 8 12 4 4 1 2 0 4 1 0.498 0.847 1.000 87 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(2), ARG1(1), GLUD1(2) 4074013 5 3 5 0 3 0 0 1 1 0 0.249 0.853 1.000 88 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 CBS(1), CTH(2), MUT(3) 3618920 6 5 6 4 1 1 0 2 2 0 0.961 0.854 1.000 89 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(1), ACP5(1), ACPP(1), ACPT(3), ALPI(1), ALPP(2), ALPPL2(2), CMBL(1), CYP3A43(1), CYP3A7(1), DHRS1(1), DHRS7(1), DHRSX(5), PON1(1), PON2(3), PON3(1) 13295315 26 19 25 5 9 3 3 6 5 0 0.0938 0.856 1.000 90 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(3), PLCB1(3), PRKCA(2), RELA(3) 6059591 11 8 11 2 3 4 1 3 0 0 0.197 0.861 1.000 91 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(2), LDLR(3), NR1H3(1), RXRA(2) 4022180 8 5 8 4 4 3 1 0 0 0 0.601 0.863 1.000 92 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 SQLE(1) 2327123 1 1 1 1 1 0 0 0 0 0 0.887 0.872 1.000 93 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 10 CDC25A(4), CDC25B(5), MYT1(2), RB1(3), WEE1(1) 7745040 15 11 15 3 6 2 1 2 3 1 0.356 0.879 1.000 94 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CYP11A1(1), CYP11B2(2), CYP17A1(1), HSD11B1(1), HSD3B1(2), HSD3B2(2) 5088783 9 6 9 2 1 2 1 2 3 0 0.345 0.886 1.000 95 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 13 ARF1(1), CDKN1A(2), CDKN2A(1), CFL1(1), E2F1(3), MDM2(1) 5300725 9 6 9 2 5 0 0 0 4 0 0.536 0.896 1.000 96 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(1), CARS(4), EPRS(4), FARS2(2), GARS(1), HARS(1), IARS(2), KARS(2), LARS(3), LARS2(2), MARS2(1), QARS(1), SARS(2), TARS(3), WARS(1), WARS2(2), YARS(3) 23701989 35 25 35 4 13 7 5 8 2 0 0.0115 0.896 1.000 97 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(1), PSMA2(1), PSMA4(1), PSMA6(1), PSMB2(1), PSMB3(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMD14(1), RPN1(1), RPN2(2), UBE3A(1) 9519258 15 8 15 1 3 3 2 3 4 0 0.0401 0.897 1.000 98 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLUD1(2), GLUD2(2) 3361215 4 4 4 2 2 1 0 1 0 0 0.784 0.898 1.000 99 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(1), CD34(1), CD3D(1), CD4(1), CD8A(1), IL6(1) 4570972 6 6 6 3 1 2 0 2 1 0 0.691 0.899 1.000 100 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 14 APAF1(2), CDKN1A(2), E2F1(3), MDM2(1), PCNA(2), RB1(3) 8146407 13 8 13 2 4 2 1 1 4 1 0.233 0.900 1.000 101 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 SHMT1(1), SHMT2(1) 3053315 2 2 2 0 1 0 0 0 1 0 0.393 0.900 1.000 102 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(3), AMT(1), ATIC(5), DHFR(2), GART(1), MTHFD1(2), MTHFD1L(4), MTHFD2(1), MTHFR(2), MTR(1), SHMT1(1), SHMT2(1), TYMS(1) 13239086 25 20 25 5 5 5 3 6 6 0 0.176 0.907 1.000 103 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 DFFA(4), HMGB2(2), TOP2A(4), TOP2B(2) 6564891 12 9 12 4 3 3 1 2 3 0 0.763 0.907 1.000 104 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 CLOCK(1), CRY2(4), CSNK1E(3), PER1(4) 6230589 12 7 12 2 4 4 1 3 0 0 0.214 0.910 1.000 105 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNGR2(1), JAK1(6), JAK2(1), STAT1(1) 6092911 9 7 9 3 0 3 1 2 3 0 0.671 0.910 1.000 106 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 13 AKT1(3), BCAR1(3), GRB2(1), ILK(1), MAPK1(1), PDK2(1), PDPK1(1), PIK3R1(2), PTK2(3), SHC1(3), SOS1(4) 11675431 23 17 22 4 9 7 0 3 4 0 0.0782 0.918 1.000 107 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 11 APC(10), AXIN1(1), BTRC(3), DLL1(3), DVL1(1), FZD1(2), GSK3B(1), NOTCH1(6), WNT1(1) 14556193 28 19 28 7 9 3 2 1 12 1 0.131 0.918 1.000 108 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(1), PSMA2(1), PSMA4(1), PSMA6(1), PSMB2(1), PSMB3(2), PSMB4(1), PSMB5(1), PSMB6(1) 6464824 10 5 10 0 0 1 2 3 4 0 0.0544 0.922 1.000 109 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(1), AKR1D1(1), ARSB(2), ARSD(1), ARSE(2), CYP11B1(1), CYP11B2(2), HSD11B1(1), HSD17B2(1), HSD17B3(1), HSD3B1(2), HSD3B2(2), STS(1), SULT1E1(2), UGT1A1(2), UGT1A10(1), UGT1A4(1), UGT1A7(2), UGT1A9(2), UGT2B15(3), UGT2B4(1) 20092640 32 26 32 5 7 6 2 11 6 0 0.0487 0.924 1.000 110 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 24 AKT1(3), APC(10), AXIN1(1), CD14(2), DVL1(1), FZD1(2), GJA1(1), GNAI1(2), GSK3B(1), IRAK1(1), LEF1(2), LY96(1), NFKB1(3), PDPK1(1), PIK3R1(2), PPP2CA(2), RELA(3), TIRAP(1), TLR4(2), WNT1(1) 19780849 42 34 41 9 11 11 3 5 12 0 0.0405 0.927 1.000 111 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(3), AMT(1), ATIC(5), DHFR(2), GART(1), MTHFD1(2), MTHFD1L(4), MTHFD2(1), MTHFR(2), MTR(1), SHMT1(1), SHMT2(1), TYMS(1) 13984942 25 20 25 5 5 5 3 6 6 0 0.178 0.935 1.000 112 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 14 AKT1(3), GRB2(1), HRAS(4), IGF1R(4), IRS1(3), MAPK1(1), PIK3R1(2), RAF1(1), SHC1(3), SOS1(4) 12416513 26 22 23 6 9 3 6 4 4 0 0.206 0.935 1.000 113 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNB1(1), IL10(1), IL12A(1), IL12B(1), IL16(5), IL1A(1), IL4(1), IL6(1), IL9(2), TNF(1) 7357338 15 13 15 5 5 3 1 3 3 0 0.425 0.938 1.000 114 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 13 ACTR3(1), PAK1(1), PDGFRA(3), PIK3R1(2), RAC1(1) 8290896 8 8 8 2 3 1 1 1 2 0 0.610 0.939 1.000 115 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(1), GRB2(1), HRAS(4), SHC1(3), SOS1(4) 6472275 13 11 11 4 7 1 3 0 2 0 0.390 0.939 1.000 116 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(2), CHST11(3), CHST12(1), CHST13(1), PAPSS2(1), SULT1A1(1), SULT1E1(2), SUOX(1) 6801496 12 11 12 4 7 1 1 1 2 0 0.495 0.946 1.000 117 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 CSAD(1), GAD1(2), GAD2(9) 4229060 12 11 12 7 6 1 1 2 2 0 0.830 0.946 1.000 118 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(1), ACTR3(1), RAC1(1), WASF1(2) 6004781 5 5 5 2 1 1 1 2 0 0 0.738 0.948 1.000 119 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 6 AKT1(3), PIK3R1(2), PLCB1(3), PLCG1(1), PRKCA(2), VAV1(3) 7862314 14 12 13 4 5 3 0 5 1 0 0.531 0.948 1.000 120 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAS1(3), ALAS2(1), CPOX(1), HMBS(1) 5476540 6 5 6 2 2 1 0 2 1 0 0.633 0.949 1.000 121 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(2), BCL2L11(1), CASP9(1), CES1(3) 7875441 7 5 7 1 0 1 0 6 0 0 0.494 0.949 1.000 122 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(1), DPYD(3), DPYS(2), ENPP1(3), ENPP3(2), PANK1(3), PANK2(3), PANK3(1), PPCS(1) 10284280 19 17 18 5 4 5 3 3 4 0 0.384 0.949 1.000 123 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 DCXR(2), UGDH(2), UGT1A1(2), UGT1A10(1), UGT1A4(1), UGT1A7(2), UGT1A9(2), UGT2B15(3), UGT2B4(1) 12998242 16 13 16 3 3 4 1 6 2 0 0.235 0.950 1.000 124 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADS(2), ACADVL(1), ACSL1(3), CPT1A(1), CPT2(2), EHHADH(5), PECR(1), SCP2(3), SLC25A20(1) 12426847 19 15 18 4 8 3 1 2 5 0 0.217 0.958 1.000 125 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(2), ACAT2(1), HMGCL(1), HMGCS1(1), HMGCS2(1), OXCT1(5) 5310767 11 7 11 3 3 2 2 4 0 0 0.492 0.959 1.000 126 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(1), HLCS(2) 2274600 3 2 3 2 1 2 0 0 0 0 0.769 0.959 1.000 127 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(3), EXT2(3), EXTL1(3), EXTL3(4), GLCE(1), HS2ST1(1), HS3ST3A1(1), HS6ST1(3), HS6ST2(1), NDST1(3), NDST2(5), NDST3(3), NDST4(6) 15152444 37 30 37 9 10 8 7 7 5 0 0.119 0.960 1.000 128 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(2), BHMT(2), CBS(1), CTH(2), DNMT1(3), DNMT3A(2), DNMT3B(6), MARS2(1), MAT1A(3), MTR(1) 12787066 23 17 23 5 9 4 2 2 6 0 0.114 0.960 1.000 129 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(1), PSMA2(1), PSMA4(1), PSMA6(1), PSMB2(1), PSMB3(2), PSMB4(1), PSMB5(1), PSMB6(1), PSMC2(1), PSMD1(2), PSMD11(1), PSMD2(1), PSMD6(1) 11847507 16 9 16 1 3 2 2 5 4 0 0.0481 0.961 1.000 130 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(1), ACP5(1), ACPP(1), ACPT(3), ENPP1(3), ENPP3(2), LHPP(1), MTMR2(4), MTMR6(1), RFK(1), TYR(2) 11112397 20 18 19 5 4 4 3 4 5 0 0.299 0.961 1.000 131 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNB1(1), JAK1(6), STAT1(1), STAT2(2), TYK2(2) 7997376 12 9 12 5 1 3 1 3 4 0 0.735 0.962 1.000 132 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL4R(3), JAK1(6), JAK2(1), TYK2(2) 7753804 13 10 13 4 1 3 2 3 4 0 0.496 0.962 1.000 133 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL4R(3), JAK1(6), JAK2(1), TYK2(2) 7753804 13 10 13 4 1 3 2 3 4 0 0.496 0.962 1.000 134 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(1), ALOX15(2), ALOX5(1), DPEP1(2), LTC4S(1), PLA2G2A(1), PLA2G6(2), PTGIS(2), PTGS1(2), PTGS2(5), TBXAS1(2) 11011159 21 14 21 4 9 4 0 5 3 0 0.0741 0.963 1.000 135 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(2), PDXK(1), PSAT1(1) 3590408 4 3 4 3 0 2 0 1 1 0 0.895 0.968 1.000 136 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(2), ALDOC(3) 2883535 5 3 5 2 0 2 2 1 0 0 0.649 0.968 1.000 137 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRB(1), HMOX1(2), IL10(1), IL10RA(2), IL1A(1), IL6(1), JAK1(6), STAT1(1), STAT3(6), TNF(1) 8989834 22 17 22 8 6 4 3 5 4 0 0.468 0.969 1.000 138 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 CAT(2), EPX(4), LPO(2), MPO(3), PRDX1(1), SHMT1(1), SHMT2(1), TPO(5) 8682929 19 15 19 5 9 2 1 5 2 0 0.270 0.971 1.000 139 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 CREB1(1), KEAP1(4), MAFF(1), MAPK1(1), NFE2L2(1), PRKCA(2) 6501032 10 8 10 3 4 2 2 2 0 0 0.376 0.971 1.000 140 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(2), CD2(1), CD3D(1), CD4(1), IL12A(1), IL12B(1), IL12RB2(1), JAK2(1), STAT4(6), TYK2(2) 10735192 17 13 17 5 1 4 2 6 4 0 0.436 0.971 1.000 141 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CDC25A(4), CDC25B(5), GRB2(1), PRKCA(2), PTPRA(5) 6781748 17 12 17 5 8 3 1 3 2 0 0.377 0.971 1.000 142 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(1), RAB11A(1), RAB3A(1) 3132633 3 3 3 4 1 0 0 1 1 0 0.975 0.971 1.000 143 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(1), CYP2A13(3), CYP2A6(3), CYP2A7(2), NAT2(1), XDH(1) 5907141 11 8 11 4 6 1 1 2 1 0 0.603 0.973 1.000 144 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 IDI2(2), SQLE(1) 3129059 3 2 3 2 1 0 1 0 1 0 0.791 0.975 1.000 145 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 11 ASAH1(1), CREB1(1), MAPK1(1), RAF1(1), SNX13(3), TERF2IP(1) 7057611 8 8 8 5 2 1 1 1 3 0 0.946 0.975 1.000 146 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(6), JAK2(1), JAK3(1), MAPK1(1), STAT3(6), TYK2(2) 8612725 17 14 17 9 2 4 2 5 4 0 0.881 0.977 1.000 147 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 NFKB1(3), RELA(3), TNFRSF13B(3), TRAF2(5), TRAF5(1), TRAF6(2) 10668296 17 9 17 3 6 4 1 4 2 0 0.111 0.977 1.000 148 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 20 AKT1(3), CDKN1A(2), E2F1(3), HRAS(4), MAPK1(1), NFKB1(3), PAK1(1), PIK3R1(2), RAC1(1), RAF1(1), RB1(3), RELA(3), TFDP1(2) 12968362 29 21 26 6 8 5 8 2 5 1 0.125 0.979 1.000 149 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(3), APOBEC1(3), APOBEC2(1), APOBEC3B(4), APOBEC3G(1) 5431405 12 10 12 5 5 1 2 2 2 0 0.761 0.979 1.000 150 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(1), B4GALT1(2), B4GALT2(2), B4GALT3(1), B4GALT5(1), FUT8(2), ST3GAL1(2), ST3GAL3(1) 5778649 12 9 12 4 6 2 0 4 0 0 0.603 0.979 1.000 151 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ECHS1(1), EHHADH(5), SDS(1) 8937545 19 16 18 6 6 3 3 4 3 0 0.457 0.980 1.000 152 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 ALOX15(2), ALOX5(1), CYP1A2(1), CYP2C18(2), CYP2C19(4), CYP2C8(4), CYP2C9(3), CYP2E1(1), CYP2J2(1), CYP3A43(1), CYP3A7(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(4), PLA2G5(1), PLA2G6(2), RDH12(1) 17628767 31 21 31 6 10 2 3 10 6 0 0.155 0.980 1.000 153 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 15 AKT1(3), CREB1(1), MAP2K3(1), MAP2K6(1), MAP3K1(5), MAPK1(1), NFKB1(3), PIK3R1(2), RB1(3), RELA(3), SP1(2) 12680547 25 17 24 5 6 9 2 2 5 1 0.113 0.982 1.000 154 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(1), NRF1(2), UBE2C(1), UBE2I(1), UBE2L3(1), UBE2S(1), UBE3A(1) 7766740 8 7 8 3 2 1 2 2 1 0 0.606 0.982 1.000 155 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(1), CHAT(4), PCYT1A(1), PDHA1(1), PDHA2(4), SLC18A3(1) 5098348 12 9 11 6 4 4 0 1 3 0 0.537 0.983 1.000 156 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ENO1(3), HK1(2), PFKL(2), PKLR(1) 6798617 8 5 8 4 5 0 0 0 3 0 0.704 0.983 1.000 157 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(1), DHRS7(1), DHRSX(5), ESCO1(5), ESCO2(1), NAT6(1), SH3GLB1(1) 12248012 15 11 15 3 6 0 2 3 4 0 0.265 0.984 1.000 158 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 RDH12(1) 3513530 1 1 1 1 1 0 0 0 0 0 0.894 0.985 1.000 159 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 14 FLT3(2), IL1A(1), IL6(1), IL9(2), TGFB2(2) 6008566 8 8 8 9 1 1 3 1 2 0 0.994 0.986 1.000 160 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(1), SHMT1(1), SHMT2(1) 4009978 3 3 3 2 1 1 0 0 1 0 0.739 0.986 1.000 161 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 CAT(2), EPX(4), LPO(2), MPO(3), MTHFR(2), SHMT1(1), SHMT2(1), TPO(5) 8551912 20 16 20 5 10 3 1 4 2 0 0.214 0.987 1.000 162 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(3), EGFR(3), ERBB3(5), NRG1(4) 7598482 15 13 15 5 2 2 0 9 2 0 0.648 0.987 1.000 163 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(1), CD4(1), FYN(1), HLA-DRA(1), PTPRC(8), ZAP70(6) 6687301 18 15 18 7 7 4 2 5 0 0 0.493 0.987 1.000 164 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAS1(3), ALAS2(1), HMBS(1) 5588764 5 4 5 2 2 1 0 1 1 0 0.715 0.988 1.000 165 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(2), ST3GAL1(2), ST6GALNAC2(1), ST6GALNAC4(2), ST8SIA1(1) 4146376 8 8 8 7 4 2 0 1 1 0 0.947 0.989 1.000 166 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(1), ALPP(2), ALPPL2(2), DHFR(2), FPGS(1), SPR(1) 4783176 9 8 9 6 3 3 0 1 2 0 0.851 0.989 1.000 167 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CD36(1), FYN(1), THBS1(3) 5462957 5 4 5 2 2 1 1 1 0 0 0.628 0.989 1.000 168 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 21 ADCY1(2), AKT1(3), ASAH1(1), GNAI1(2), GNB1(1), GNGT1(1), ITGAV(3), MAPK1(1), PDGFA(2), PDGFRA(3), PIK3R1(2), PLCB1(3), PRKCA(2), PTK2(3), RAC1(1), SMPD2(2), SPHK1(1) 18623703 33 25 32 7 12 8 2 8 3 0 0.0899 0.989 1.000 169 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(3), FUCA1(1), FUCA2(1), GLB1(2), HEXB(2), LCT(6), MAN2B1(3), MAN2B2(2), MAN2C1(3), NEU1(1), NEU2(2), NEU4(2) 14998628 28 20 28 9 14 3 1 4 6 0 0.348 0.989 1.000 170 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNB1(1), JAK1(6), PTPRU(4), REG1A(1), STAT1(1), STAT2(2), TYK2(2) 9219819 17 12 17 7 4 4 1 4 4 0 0.668 0.990 1.000 171 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(2), PLCD1(1), PRKCA(2), TGM2(1) 3607014 6 5 6 4 3 1 0 1 1 0 0.814 0.990 1.000 172 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(3), ATP6V0B(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1C2(5), ATP6V1F(1), ATP6V1H(1), SHMT1(1) 11096494 17 13 17 4 3 3 2 5 4 0 0.367 0.990 1.000 173 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(3), ATP6V0B(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1C2(5), ATP6V1F(1), ATP6V1H(1), SHMT1(1) 11096494 17 13 17 4 3 3 2 5 4 0 0.367 0.990 1.000 174 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(3), ATP6V0B(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1C2(5), ATP6V1F(1), ATP6V1H(1), SHMT1(1) 11096494 17 13 17 4 3 3 2 5 4 0 0.367 0.990 1.000 175 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(2), AMD1(1), BHMT(2), CBS(1), CTH(2), DNMT1(3), DNMT3A(2), DNMT3B(6), MARS2(1), MAT1A(3), MTAP(1), MTR(1), SRM(1) 15213906 26 18 26 7 11 4 2 3 6 0 0.178 0.990 1.000 176 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(1), APAF1(2), CASP9(1), DAXX(2), FAS(1), FASLG(1), IL1A(1), MAPKAPK3(1), TNF(1) 8362558 11 10 11 6 2 1 1 4 3 0 0.945 0.990 1.000 177 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(1), ACO2(1), CS(3), HAO1(2), MDH1(1), MTHFD1(2), MTHFD1L(4), MTHFD2(1) 9460948 15 11 15 4 2 2 5 3 3 0 0.347 0.991 1.000 178 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(2), CYSLTR2(1), GPR171(1), GPR18(2), GPR39(3), GPR45(2), GPR68(2), GPR75(2) 7250189 15 8 15 4 5 2 0 7 1 0 0.374 0.991 1.000 179 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 B3GNT1(1), FUT1(1), FUT2(1), ST8SIA1(1) 4515877 4 4 4 5 0 3 0 0 1 0 0.972 0.991 1.000 180 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(2), CS(3), MDH1(1), ME1(3), PC(2), PDHA1(1) 6802237 12 7 12 3 1 3 2 2 4 0 0.309 0.991 1.000 181 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(1), CAMK1(3), CAMK1G(2), CAMK2A(1), CAMK2D(2), CAMK4(4), CAMKK1(2), CREB1(1), SYT1(1) 8491574 17 11 17 6 7 2 0 6 2 0 0.559 0.992 1.000 182 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 IL4(1), MAP2K3(1), NFATC1(2), NFATC2(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1) 8913820 13 10 13 5 4 2 2 5 0 0 0.521 0.992 1.000 183 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 12 CCNA1(1), CCNE2(1), CDKN2A(1), E2F1(3) 6291671 6 5 6 2 2 1 0 1 2 0 0.648 0.992 1.000 184 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(3), FUCA1(1), FUCA2(1), GLB1(2), HEXB(2), LCT(6), MAN2C1(3), NEU1(1), NEU2(2), NEU4(2) 12164815 23 18 23 8 10 3 1 3 6 0 0.488 0.992 1.000 185 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1) 5873133 12 10 11 5 3 1 3 3 2 0 0.736 0.992 1.000 186 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1) 5873133 12 10 11 5 3 1 3 3 2 0 0.736 0.992 1.000 187 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(1), CS(3), FH(3), MDH1(1), SDHA(3), SUCLA2(1) 6939714 12 7 12 3 0 2 3 4 3 0 0.329 0.993 1.000 188 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(1), ARFGAP3(2), ARFGEF2(2), CLTB(1), COPA(2), GBF1(6), GPLD1(3), KDELR1(1), KDELR3(1) 12001371 19 14 19 5 7 4 2 2 4 0 0.223 0.993 1.000 189 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 CREBBP(8), DFFA(4), GZMA(1), HMGB2(2), NME1(1), PRF1(2) 7814343 18 14 18 9 4 5 2 4 3 0 0.831 0.994 1.000 190 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(1), ACO2(1), CS(3), HAO1(2), MDH1(1), MTHFD1(2), MTHFD1L(4), MTHFD2(1) 9904861 15 11 15 4 2 2 5 3 3 0 0.345 0.994 1.000 191 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH7A1(2), CYP2C19(4), CYP2C9(3), DHRS1(1), DHRS7(1), DHRSX(5), ECHS1(1), EHHADH(5), ESCO1(5), ESCO2(1), NAT6(1), SH3GLB1(1) 22799486 36 28 36 7 13 3 5 9 6 0 0.0891 0.994 1.000 192 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(3), CAMK1G(2), HDAC9(2), MEF2A(1), MEF2C(3), MEF2D(1) 5592666 12 10 12 5 5 2 1 4 0 0 0.642 0.994 1.000 193 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 EIF2S1(1), NFKB1(3), RELA(3) 6550385 7 4 7 2 1 3 2 1 0 0 0.430 0.994 1.000 194 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CSF1(1), MST1R(3), TNF(1) 4825463 5 5 5 3 3 0 0 0 2 0 0.861 0.995 1.000 195 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(1), BCAT2(1), DPYD(3), DPYS(2), ENPP1(3), ENPP3(2), ILVBL(3), PANK1(3), PANK2(3), PANK3(1), PPCS(1) 12774758 23 19 22 7 5 5 3 4 6 0 0.477 0.995 1.000 196 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(1), BCAT2(1), IARS(2), IARS2(1), ILVBL(3), LARS(3), LARS2(2), PDHA1(1), PDHA2(4), VARS(4), VARS2(4) 13665443 26 18 25 5 5 5 1 10 5 0 0.184 0.995 1.000 197 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 21 CCNA1(1), CCND3(1), CCNH(1), CDC25A(4), CDK7(2), CDKN1A(2), CDKN2A(1), E2F1(3), RB1(3), RBL1(2), TFDP1(2) 11571372 22 14 22 8 7 3 3 2 6 1 0.543 0.995 1.000 198 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 20 AKT1(3), CASP9(1), HRAS(4), NFKB1(3), PIK3R1(2), RAC1(1), RAF1(1), RALBP1(1), RALGDS(2), RELA(3), RHOA(2) 12305615 23 19 19 6 3 6 6 6 2 0 0.253 0.995 1.000 199 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 8 ACO1(1), ACO2(1), FH(3), MDH1(1), SDHB(2), SUCLA2(1) 5949838 9 6 9 3 0 3 3 2 1 0 0.463 0.995 1.000 200 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 GOT1(2), GOT2(1), TYR(2) 3455567 5 5 5 3 3 1 0 1 0 0 0.812 0.995 1.000 201 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(3), FUT1(1), FUT2(1), GBGT1(1), HEXB(2), NAGA(1), ST3GAL1(2), ST8SIA1(1) 7433064 12 11 12 8 5 5 0 0 2 0 0.869 0.996 1.000 202 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 DCXR(2), UGDH(2), UGP2(1), UGT1A1(2), UGT1A10(1), UGT1A4(1), UGT1A7(2), UGT1A9(2), UGT2A1(1), UGT2A3(3), UGT2B10(4), UGT2B11(2), UGT2B15(3), UGT2B17(1), UGT2B28(2), UGT2B4(1), UGT2B7(3), XYLB(1) 20209130 34 25 34 7 5 5 4 15 5 0 0.168 0.996 1.000 203 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 18 APAF1(2), BIK(1), BIRC2(1), CASP8(1), CASP9(1), DFFA(4) 9942795 10 6 10 2 1 5 0 3 1 0 0.347 0.996 1.000 204 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(1), CPS1(4), GLUD1(2), GOT1(2) 5754870 9 7 9 5 4 1 0 3 1 0 0.854 0.996 1.000 205 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(1), CASP10(1), CASP8(1), CFLAR(2), DAXX(2), DFFA(4), FAF1(4), LMNA(4), LMNB2(2), MAP2K4(4), MAP3K1(5), MAP3K7(2), PAK1(1), PAK2(2), PRKDC(11), PTPN13(1), RB1(3), RIPK2(2), SPTAN1(2) 29878586 54 34 54 8 18 12 5 9 9 1 0.0101 0.996 1.000 206 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(1), CD3D(1), HLA-A(1), ICAM1(1), ITGAL(5), ITGB2(2), PRF1(2) 6429255 13 12 12 9 7 1 0 3 2 0 0.882 0.996 1.000 207 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 16 CD28(2), CD3D(1), CD86(1), GRB2(1), HLA-DRA(1), ITK(3), PIK3R1(2), PTPN11(1) 7852540 12 8 12 4 7 2 1 0 2 0 0.509 0.996 1.000 208 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(8), EP300(7), ESR1(2), MAPK1(1), PELP1(2) 10811985 20 16 20 6 8 3 2 4 3 0 0.395 0.996 1.000 209 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(2), ACOX1(2), ACOX3(1), ELOVL6(3), FADS2(1), FASN(5), PECR(1), SCD(2) 10405150 17 10 17 6 5 0 2 4 6 0 0.587 0.996 1.000 210 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(4), HK1(2), HK2(4), HK3(4), IMPA1(2), PGM3(1) 7527964 17 9 17 4 9 2 1 3 2 0 0.211 0.996 1.000 211 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 CAPN1(2), CAPNS1(2), GSK3B(1), PPP2CA(2) 6791163 7 5 7 4 3 1 0 1 2 0 0.885 0.996 1.000 212 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(2), CD86(1), HLA-DRA(1), IFNGR2(1), IL12A(1), IL12B(1), IL12RB2(1), IL4(1), IL4R(3) 9366151 12 9 12 4 2 1 1 3 5 0 0.645 0.996 1.000 213 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(3), B3GALNT1(1), B3GALT5(3), FUT1(1), FUT2(1), GBGT1(1), HEXB(2), NAGA(1), ST3GAL1(2), ST8SIA1(1) 7893220 16 14 16 8 7 5 0 2 2 0 0.721 0.997 1.000 214 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM1(1), CDKN1A(2), MARCKS(1), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), PLCG1(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKCA(2), SP1(2), SP3(3), SYT1(1) 15469956 24 18 24 6 7 2 1 7 7 0 0.344 0.997 1.000 215 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 ICAM1(1), ITGA4(3), ITGAL(5), ITGAM(3), ITGB2(2), SELE(1), SELP(4) 11703103 19 17 18 7 9 1 5 3 1 0 0.400 0.997 1.000 216 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(3), C5(3), C6(5), C8A(3), C9(3) 9284566 17 11 17 8 5 2 1 4 5 0 0.751 0.997 1.000 217 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOC(3), FBP1(2), FBP2(1), GOT1(2), GOT2(1), MDH1(1), ME1(3), ME2(1), ME3(1), PKLR(1), TKT(2) 13251252 18 10 18 3 4 4 3 5 2 0 0.0858 0.998 1.000 218 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 5 ATR(3) 6611195 3 3 3 2 1 0 0 1 1 0 0.944 0.998 1.000 219 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(3), POLR2A(6), POLR2B(4), POLR2C(1), POLR2E(1), POLRMT(1) 9870752 16 11 16 4 7 3 2 3 1 0 0.287 0.998 1.000 220 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 IFNB1(1), NFKB1(3), RELA(3), TNFSF11(1), TRAF6(2) 8145196 10 5 10 2 2 3 1 2 2 0 0.286 0.998 1.000 221 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 JAK1(6), JAK2(1), PLA2G2A(1), PTPRU(4), REG1A(1), STAT1(1) 8491773 14 10 14 5 3 4 1 4 2 0 0.562 0.998 1.000 222 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(5), PRKAG1(3), PRKAR2A(1) 7444424 9 4 9 2 3 2 2 2 0 0 0.326 0.998 1.000 223 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(3), ADORA2A(2), ADORA3(3), P2RY1(1), P2RY2(2), P2RY6(1) 4409058 12 9 12 6 5 2 1 3 1 0 0.651 0.998 1.000 224 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ADH1A(1), ADH1B(1), ADH4(1), ADH6(3), ADHFE1(1), DHRS1(1), DHRS7(1), DHRSX(5), ESCO1(5), ESCO2(1), NAT6(1), SH3GLB1(1) 18432810 22 14 22 4 8 1 3 5 5 0 0.121 0.998 1.000 225 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 12 CREBBP(8), DAXX(2), HRAS(4), PAX3(4), PML(1), RARA(1), RB1(3), SIRT1(3), SP100(2), TNF(1), TNFRSF1A(1), TNFRSF1B(1) 13392447 31 25 29 9 7 4 10 6 3 1 0.326 0.998 1.000 226 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH7A1(2), UGDH(2) 6265694 10 9 10 5 1 1 3 4 1 0 0.851 0.998 1.000 227 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(1), ADH1B(1), ADH4(1), ADH6(3), ADHFE1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH7A1(2) 9769159 15 12 15 5 3 2 3 5 2 0 0.519 0.998 1.000 228 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 DLL1(3), FURIN(1), NOTCH1(6) 6773733 10 5 10 5 5 1 1 1 1 1 0.639 0.998 1.000 229 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA10(2), NDUFA5(1), NDUFB7(1), NDUFS2(2), NDUFV1(1) 5118808 7 6 7 3 1 1 3 2 0 0 0.736 0.999 1.000 230 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 31 DUSP1(1), MAP2K4(4), MAP2K7(4), MAPK1(1), MAPK12(1), MAPK13(1), MAPK8IP3(4), MAPKAPK5(1), NFKB1(3), NFKBIB(2), NFKBIE(1), NFKBIL1(1), PIK3CD(5), PIK3R1(2), SYT1(1), TRAF2(5), TRAF5(1), TRAF6(2) 23067751 40 25 40 7 17 5 0 8 10 0 0.0276 0.999 1.000 231 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(10), MAP2(4), PPP1CA(1), PPP2CA(2), PRKAG1(3), PRKAR2A(1), PRKCE(2) 13446229 23 16 23 8 1 3 4 10 5 0 0.736 0.999 1.000 232 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 18 ADCY1(2), ARHGEF1(5), F2(2), F2R(2), GNA13(2), GNAI1(2), GNB1(1), GNGT1(1), MAP3K7(2), PIK3R1(2), PLCB1(3), PPP1R12B(1), PRKCA(2), ROCK1(5) 17381186 32 26 31 9 11 4 4 9 4 0 0.368 0.999 1.000 233 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(3), GRB2(1), IL4(1), IL4R(3), IRS1(3), JAK1(6), JAK3(1), SHC1(3), STAT6(3) 10820307 24 20 23 9 7 4 2 7 4 0 0.655 0.999 1.000 234 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(2), CD38(1), ENPP1(3), ENPP3(2), NADSYN1(1), NMNAT1(1), NNMT(1), NNT(2), NT5E(1), NT5M(1) 10732148 15 15 15 8 3 3 1 5 3 0 0.833 0.999 1.000 235 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 17 IFNGR2(1), IKBKB(1), JAK2(1), NFKB1(3), RB1(3), RELA(3), TNF(1), TNFRSF1A(1), TNFRSF1B(1), USH1C(2), WT1(2) 12707361 19 10 19 4 4 6 3 2 3 1 0.153 0.999 1.000 236 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 CTSD(2), ESR1(2), GREB1(2), MTA1(2), TUBA8(1) 7905096 9 8 9 6 3 1 3 0 2 0 0.849 0.999 1.000 237 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 15 B3GAT1(1), B3GAT3(2), CHPF(1), CHST11(3), CHST12(1), CHST13(1), CHST3(3), CHSY1(1), DSE(1), UST(1), XYLT1(6), XYLT2(1) 10025365 22 20 22 8 12 3 1 3 3 0 0.377 0.999 1.000 238 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(2), PLCG1(1), PRKCA(2) 4925307 5 5 5 7 2 1 0 1 1 0 0.989 0.999 1.000 239 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(2), FHL5(4), FSHR(2), GNAS(2) 7049295 10 8 10 4 2 2 2 4 0 0 0.764 0.999 1.000 240 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(2), DHRS1(1), DHRS7(1), DHRSX(5), HEMK1(1), LCMT1(1), LCMT2(1), METTL6(1), PRMT3(2), PRMT5(2), PRMT7(1), PRMT8(1) 11060009 19 11 19 7 7 2 2 4 4 0 0.558 0.999 1.000 241 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(1), LDLR(3), MBTPS1(3), MBTPS2(1), SCAP(2), SREBF1(2), SREBF2(2) 8745598 14 10 14 8 5 1 0 5 3 0 0.905 0.999 1.000 242 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(4), HK1(2), HK2(4), HK3(4), IMPA1(2), PGM3(1) 8571630 17 9 17 4 9 2 1 3 2 0 0.193 0.999 1.000 243 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR1(3), CCR2(3), CCR3(1), CCR4(1), CCR5(2), CCR7(3), CD28(2), CD4(1), IFNGR2(1), IL12A(1), IL12B(1), IL12RB2(1), IL4(1), IL4R(3), TGFB2(2) 14647280 26 20 26 7 3 2 3 12 6 0 0.441 0.999 1.000 244 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 IL6(1), JAK1(6), JAK2(1), JAK3(1), PIAS3(2), PTPRU(4), REG1A(1), STAT3(6) 11199244 22 16 22 9 3 6 3 6 4 0 0.648 0.999 1.000 245 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(2), HEMK1(1), LCMT1(1), LCMT2(1), METTL6(1), PCYT1A(1), PCYT1B(1), PRMT3(2), PRMT5(2), PRMT7(1), PRMT8(1) 10296349 14 9 14 8 3 3 2 3 3 0 0.883 0.999 1.000 246 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 14 AKT1(3), AKT2(1), AKT3(1), BPNT1(2), GRB2(1), ILK(1), MAPK1(1), PDK1(2), PIK3CD(5), RBL2(2), SHC1(3), SOS1(4) 12826079 26 23 25 9 11 4 2 4 5 0 0.451 0.999 1.000 247 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 CLOCK(1), CRY2(4), CSNK1E(3), NPAS2(1), NR1D1(3), PER1(4), PER2(4), PER3(2) 12567640 22 15 22 6 8 5 1 6 2 0 0.312 0.999 1.000 248 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(2), CALCR(4), CALCRL(1), CD97(2), CRHR2(2), ELTD1(1), EMR2(7), GHRHR(1), GIPR(2), GLP1R(1), GLP2R(1), GPR64(1), LPHN1(3), LPHN2(6), LPHN3(9), SCTR(3) 19531472 46 38 45 12 14 6 5 13 8 0 0.112 0.999 1.000 249 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 14 AKT1(3), EGFR(3), IGF1R(4), MYC(1), POLR2A(6), PPP2CA(2), PRKCA(2), RB1(3), TEP1(5), TNKS(5) 20109073 34 25 33 8 6 10 4 10 3 1 0.130 0.999 1.000 250 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(2), DYRK1B(4), GLI2(3), GLI3(3), GSK3B(1), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), SHH(2), SUFU(1) 12250592 23 16 23 7 5 3 3 8 4 0 0.380 0.999 1.000 251 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 HRAS(4), MAPK1(1), MYC(1), NFKB1(3), PLCB1(3), PRKCA(2), RAF1(1), RELA(3), TNF(1) 11456384 19 15 17 6 6 4 5 4 0 0 0.320 0.999 1.000 252 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 20 AKT1(3), EIF4A1(1), EIF4E(1), EIF4G1(4), EIF4G2(1), EIF4G3(6), GHR(1), IRS1(3), MAPK1(1), PDK2(1), PDPK1(1), PIK3R1(2), PRKCA(2) 18565129 27 21 26 6 7 4 0 10 6 0 0.319 0.999 1.000 253 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(8), EP300(7), LPL(1), NCOA1(1), NCOA2(2), PPARG(1), RXRA(2) 13659850 22 16 22 8 7 3 4 6 2 0 0.515 1.000 1.000 254 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT1(1), FUT2(1), FUT3(2), ST3GAL3(1) 3754195 5 5 5 3 1 2 1 1 0 0 0.800 1.000 1.000 255 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 28 CD4(1), CSF1(1), HLA-DRA(1), IFNB1(1), IL10(1), IL12A(1), IL12B(1), IL1A(1), IL4(1), IL6(1), IL7(2), PDGFA(2), TGFB2(2), TNF(1) 9712960 17 14 17 8 6 2 2 3 4 0 0.707 1.000 1.000 256 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(2), ACAT2(1), DHRS1(1), DHRS7(1), DHRSX(5), ECHS1(1), EHHADH(5), ESCO1(5), ESCO2(1), GCDH(1), NAT6(1), SH3GLB1(1) 19176942 25 19 25 5 11 1 2 6 5 0 0.161 1.000 1.000 257 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(2), CARM1(2), CBS(1), CTH(2), HEMK1(1), LCMT1(1), LCMT2(1), MARS2(1), MAT1A(3), METTL6(1), PAPSS2(1), PRMT3(2), PRMT5(2), PRMT7(1), PRMT8(1), SEPHS1(1), SEPHS2(3) 18352130 26 19 26 8 6 5 4 5 6 0 0.418 1.000 1.000 258 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG5(1), B4GALT1(2), B4GALT2(2), B4GALT3(1), B4GALT5(1), DDOST(1), DPM1(2), FUT8(2), MAN1A1(2), MAN1B1(1), MGAT3(1), MGAT4A(1), MGAT5(1), RPN1(1), RPN2(2), ST6GAL1(1) 14623681 22 17 22 6 6 6 1 8 1 0 0.342 1.000 1.000 259 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 12 ACTN1(1), ACTN2(2), BCAR1(3), CTNNA1(2), CTNNA2(5), PTK2(3), PXN(1), VCL(1) 12861649 18 12 18 7 7 2 1 3 5 0 0.638 1.000 1.000 260 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(2), PDE1B(1), PLCB1(3), PLCB2(1), PRL(1) 8190295 8 7 8 4 2 1 1 2 2 0 0.720 1.000 1.000 261 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 JAK1(6), JAK2(1), JAK3(1), PIAS3(2), PTPRU(4), REG1A(1) 10106977 15 10 15 9 3 4 2 3 3 0 0.912 1.000 1.000 262 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(8), ABCB11(3), ABCB4(2), ABCC1(1), ABCC3(2), GSTP1(1) 10565247 17 11 17 8 7 4 1 3 2 0 0.721 1.000 1.000 263 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(2), CD3D(1), ETV5(2), IL12A(1), IL12B(1), IL12RB2(1), JAK2(1), MAP2K6(1), STAT4(6), TYK2(2) 13663851 18 14 18 7 2 5 2 4 5 0 0.569 1.000 1.000 264 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(2), CDKN1A(2), EPOR(1), GRIN1(3), HIF1A(2), JAK2(1), NFKB1(3), RELA(3), SOD2(1) 9324828 18 11 18 5 7 5 1 3 2 0 0.369 1.000 1.000 265 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 21 ADCY1(2), AKT1(3), CSF2RB(1), IGF1R(4), IL3RA(3), KIT(3), PIK3R1(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1) 14562640 25 15 24 6 7 4 4 7 3 0 0.184 1.000 1.000 266 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(3), EGFR(3), MAP3K1(5), NCOR2(7), RARA(1), RXRA(2), THRA(6) 12633639 27 16 27 7 12 3 1 8 3 0 0.197 1.000 1.000 267 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(4), LPO(2), MPO(3), PRDX1(1), TPO(5), TYR(2) 7090384 17 13 17 7 10 2 0 5 0 0 0.582 1.000 1.000 268 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 10 ACLY(2), ACO1(1), ACO2(1), ACSS1(1), ACSS2(1), FH(3), MDH1(1), SUCLA2(1) 9166914 11 8 11 6 0 3 3 3 2 0 0.774 1.000 1.000 269 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 ICAM1(1), ITGAL(5), ITGAM(3), ITGB2(2), SELE(1) 7591645 12 11 11 6 7 1 1 2 1 0 0.626 1.000 1.000 270 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 DUSP1(1), IKBKAP(2), IKBKB(1), MAP3K1(5), NFKB1(3), RELA(3), TNFAIP3(1), TRAF6(2) 13318564 18 9 18 3 6 6 1 2 3 0 0.0673 1.000 1.000 271 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 DAB1(2), FYN(1), LRP8(2), RELN(10), VLDLR(3) 10367157 18 12 18 8 4 4 3 6 1 0 0.759 1.000 1.000 272 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(7), CPT1A(1), LEPR(2), PRKAA2(5), PRKAG1(3) 10717499 18 16 18 6 4 4 4 5 0 1 0.469 1.000 1.000 273 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 17 GRB2(1), HRAS(4), KLK2(1), PIK3R1(2), PLCG1(1), RAF1(1), SHC1(3), SOS1(4) 12384863 17 16 15 8 8 1 4 0 4 0 0.763 1.000 1.000 274 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 DUSP1(1), IKBKAP(2), IKBKB(1), MAP3K1(5), NFKB1(3), RELA(3), RIPK1(1), TANK(1), TNFAIP3(1), TNFRSF1B(1), TRAF1(1), TRAF2(5) 16493720 25 16 25 5 9 7 3 4 2 0 0.0679 1.000 1.000 275 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6V0A1(3), ATP6V0B(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1C2(5), ATP6V1F(1), ATP6V1H(1), FDXR(2), SHMT1(1) 11790670 19 14 19 6 5 3 2 5 4 0 0.549 1.000 1.000 276 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(1), ACTR3(1), NCKAP1(1), NTRK1(9), RAC1(1), WASF1(2), WASF2(2), WASF3(1) 11278021 18 14 18 6 7 5 1 3 2 0 0.508 1.000 1.000 277 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(10), ASAH1(1), CERK(1), CREB1(1), DAG1(2), EPHB2(4), ITPKB(2), MAP2K4(4), MAP2K7(4), MAPK1(1), MAPK8IP3(4) 21030077 34 27 34 10 12 4 0 6 12 0 0.361 1.000 1.000 278 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(1), CSF1R(5), EGF(3), EGFR(3), GRB2(1), MET(4), PDGFRA(3), PRKCA(2), SH3GLB1(1), SH3GLB2(2) 14333269 25 20 25 8 8 3 4 10 0 0 0.363 1.000 1.000 279 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CR1(1), CR2(2), HLA-DRA(1), ICAM1(1), ITGAL(5), ITGB2(2), PTPRC(8) 11166290 20 19 19 9 9 3 2 5 1 0 0.704 1.000 1.000 280 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 19 B2M(1), HLA-A(1), KLRC1(1), PAK1(1), PIK3R1(2), RAC1(1), SYK(2), VAV1(3) 12096368 12 12 12 5 5 0 2 2 3 0 0.864 1.000 1.000 281 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 20 ATR(3), BRCA1(1), CDC25A(4), CDC25B(5), CDC34(1), CDKN1A(2), EP300(7), MDM2(1), MYT1(2), PRKDC(11), RPS6KA1(2), WEE1(1), YWHAQ(2) 25570873 42 27 42 8 16 7 3 8 8 0 0.0831 1.000 1.000 282 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(2), GALNS(4), GLB1(2), HEXB(2), LCT(6) 10492890 16 13 16 6 9 2 0 4 1 0 0.459 1.000 1.000 283 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(1), HMGCR(1), LSS(2), MVK(1), NQO1(2), SQLE(1) 8059595 8 8 8 6 5 0 0 2 1 0 0.906 1.000 1.000 284 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(4), AGTR1(3), BDKRB2(2), NOS3(2) 7163967 11 8 11 8 4 4 0 2 1 0 0.923 1.000 1.000 285 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOC(3), DERA(1), FBP1(2), FBP2(1), H6PD(3), PFKL(2), PFKM(3), PFKP(3), PGM3(1), PRPS1L1(4), RBKS(2), TKT(2), TKTL2(4) 17897029 31 22 31 9 9 5 6 6 5 0 0.228 1.000 1.000 286 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 C9orf47(1), CNR1(5), CNR2(1), DNMT1(3), MTNR1A(1), MTNR1B(2), PTGER2(2), PTGER4(1), PTGIR(3), TBXA2R(5) 8210197 24 14 24 8 14 4 1 2 3 0 0.134 1.000 1.000 287 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(3), POLR1B(3), POLR1C(2), POLR2A(6), POLR2B(4), POLR2C(1), POLR2E(1), POLR3A(4), POLR3B(3) 17280021 27 19 27 6 9 7 2 6 3 0 0.151 1.000 1.000 288 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT2(1), AGPAT3(2), AGPAT4(2), AGPAT6(2), AGPS(1), ENPP2(3), PLA2G12B(1), PLA2G2A(1), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLD1(3), PLD2(2), PPAP2A(1), PPAP2B(1) 17069299 27 18 27 8 8 3 0 7 9 0 0.446 1.000 1.000 289 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPLD1(3), PGAP1(1), PIGA(1), PIGB(2), PIGC(1), PIGG(3), PIGH(1), PIGK(1), PIGO(2), PIGQ(3), PIGT(1) 17504899 19 13 19 6 5 3 3 4 4 0 0.492 1.000 1.000 290 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSR(1), NFKB1(3), RELA(3), TNF(1), XDH(1) 7249489 9 4 9 4 3 4 1 1 0 0 0.590 1.000 1.000 291 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(10), CDH1(4), CREBBP(8), EP300(7), MAP3K7(2), TGFB2(2), TGFBR1(2) 18974735 35 29 35 10 7 4 5 7 12 0 0.445 1.000 1.000 292 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 19 GRB2(1), HRAS(4), IGF1R(4), IRS1(3), PIK3R1(2), PTPN11(1), RAF1(1), RASA1(1), SHC1(3), SOS1(4) 16587587 24 18 22 7 10 1 6 3 4 0 0.363 1.000 1.000 293 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(2), ARHGAP5(4), ARHGDIB(1), CASP1(2), CASP10(1), CASP8(1), CASP9(1), PRF1(2) 9545885 14 9 14 6 2 4 0 7 1 0 0.783 1.000 1.000 294 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(1), GCK(4), GNE(1), GNPDA1(1), HEXB(2), HK1(2), HK2(4), HK3(4), PGM3(1), UAP1(1) 12453907 21 10 21 4 10 4 1 3 3 0 0.128 1.000 1.000 295 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT1(1), B3GNT3(3), B3GNT4(2), B3GNT5(1), B4GALT1(2), B4GALT2(2), B4GALT3(1), B4GALT4(1), FUT1(1), FUT2(1), FUT3(2), FUT4(1), ST3GAL6(1), ST8SIA1(1) 11910347 20 13 20 8 6 4 2 6 1 1 0.676 1.000 1.000 296 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOC(3), FBP1(2), FBP2(1), H6PD(3), PFKM(3), PFKP(3), PGM3(1), PRPS1L1(4), RBKS(2), TKT(2) 15057169 24 18 24 7 6 4 5 6 3 0 0.321 1.000 1.000 297 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPL13(1), RPL10A(3), RPL10L(2), RPL11(4), RPL12(1), RPL19(2), RPL28(1), RPL29(1), RPL3(1), RPL34(1), RPL35A(1), RPL36AL(1), RPL37(1), RPL3L(1), RPL6(2), RPL7(2), RPL8(1), RPS10(1), RPS11(2), RPS20(1), RPS5(1), RPS6(1), RPS9(1) 16796571 33 24 33 7 9 7 3 10 4 0 0.209 1.000 1.000 298 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLD1(3), POLD2(1), POLE(6), POLG(2), POLL(1), POLQ(6) 12333606 19 13 19 9 6 6 2 2 3 0 0.832 1.000 1.000 299 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(1), AOC2(3), AOC3(1), CES1(3), DDHD1(5), ESCO1(5), ESCO2(1), NAT6(1), SH3GLB1(1) 18634387 21 16 21 5 3 2 4 8 4 0 0.339 1.000 1.000 300 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(7), ACACB(3), FASN(5) 11469712 15 11 15 8 3 1 2 7 1 1 0.885 1.000 1.000 301 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 DHCR7(1), HMGCR(1), HMGCS1(1), LSS(2), MVK(1), SQLE(1) 9625901 7 7 7 8 4 0 0 2 1 0 0.991 1.000 1.000 302 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BET1(1), BNIP1(2), GOSR1(2), SNAP25(1), STX16(3), STX7(1), STX8(2), USE1(1), VAMP1(1), VAMP5(1), VAMP7(2), VTI1A(1), YKT6(1) 12249243 19 11 19 7 9 1 2 3 4 0 0.624 1.000 1.000 303 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(1), ATG3(1), ATG5(2), ATG7(1), BECN1(1), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(2), PIK3C3(1), PIK3R4(2), PRKAA2(5), ULK1(1), ULK2(1), ULK3(2) 15555851 24 18 24 9 7 3 5 6 3 0 0.625 1.000 1.000 304 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(1), ADSS(1), DHFR(2), MTHFD2(1), POLD1(3), POLG(2), SRM(1) 9176002 11 5 11 7 4 4 2 0 1 0 0.839 1.000 1.000 305 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH1A3(2), ALDH3A1(1), ALDH3B1(1), AOC2(3), AOC3(1), EPX(4), GOT1(2), GOT2(1), HPD(2), LPO(2), MAOA(2), MAOB(2), MPO(3), PRDX1(1), TPO(5) 16042176 32 25 32 10 11 6 1 11 3 0 0.388 1.000 1.000 306 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(1), OPRK1(1), POLR2A(6), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1) 9460940 15 6 15 5 7 4 1 3 0 0 0.357 1.000 1.000 307 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(2), ARHGDIB(1), BIRC2(1), CASP1(2), CASP10(1), CASP8(1), CASP9(1), DFFA(4), LMNA(4), LMNB2(2), PRF1(2) 14261144 21 11 21 4 5 8 0 6 2 0 0.151 1.000 1.000 308 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 ACAT1(2), ACAT2(1), ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), AOC2(3), AOC3(1), AOX1(2), ASMT(2), CAT(2), CYP19A1(2), CYP1A1(1), CYP1A2(1), CYP2A13(3), CYP2A6(3), CYP2A7(2), CYP2B6(3), CYP2C18(2), CYP2C19(4), CYP2C8(4), CYP2C9(3), CYP2E1(1), CYP2F1(2), CYP2J2(1), CYP3A7(1), CYP4B1(1), ECHS1(1), EHHADH(5), GCDH(1), KMO(2), KYNU(3), MAOA(2), MAOB(2), SDS(1), TDO2(1), TPH1(1), WARS(1), WARS2(2) 40556129 81 60 80 17 27 9 11 22 12 0 0.0433 1.000 1.000 309 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(2), BIRC2(1), CASP10(1), CASP8(1), CASP9(1), DFFA(4), PRF1(2), SCAP(2), SREBF1(2), SREBF2(2) 13435706 18 8 18 6 4 5 0 8 1 0 0.517 1.000 1.000 310 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG10B(3), ALG12(1), ALG13(1), ALG14(2), ALG5(1), ALG8(1), ALG9(1), B4GALT1(2), B4GALT2(2), B4GALT3(1), DDOST(1), DPM1(2), FUT8(2), GANAB(3), MAN1A1(2), MAN1B1(1), MAN1C1(1), MAN2A1(4), MGAT3(1), MGAT4A(1), MGAT5(1), MGAT5B(2), RFT1(2), RPN1(1), RPN2(2), ST6GAL1(1) 30971637 42 26 42 9 9 8 3 11 11 0 0.208 1.000 1.000 311 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 21 APC(10), AXIN1(1), BTRC(3), CREBBP(8), DVL1(1), FZD1(2), GSK3B(1), HDAC1(1), MAP3K7(2), MYC(1), NLK(1), PPARD(4), PPP2CA(2), TLE1(4), WIF1(2), WNT1(1) 20453145 44 32 44 12 11 7 5 5 16 0 0.238 1.000 1.000 312 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 CASP8(1), MAP2K4(4), MAP3K1(5), MAPK1(1), NFKB1(3), NSMAF(4), RAF1(1), RELA(3), RIPK1(1), TNFRSF1A(1), TRAF2(5) 15053753 29 17 29 9 9 9 3 7 1 0 0.264 1.000 1.000 313 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(1), CS(3), DLAT(1), DLD(2), FH(3), IDH3A(1), IDH3B(1), MDH1(1), PC(2), PDHA1(1), PDHA2(4), PDHX(1), PDK1(2), PDK2(1), PDK3(1), PDK4(2), PDP2(1), SDHA(3), SDHB(2), SDHC(2), SUCLA2(1) 20860720 36 24 35 9 3 11 3 10 9 0 0.128 1.000 1.000 314 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOC(3), FBP1(2), FBP2(1), GOT1(2), GOT2(1), MDH1(1), ME1(3), ME3(1), PGK2(2), PKLR(1), TKT(2), TKTL2(4) 14830288 23 14 23 5 6 5 4 5 3 0 0.101 1.000 1.000 315 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(2), ALDH18A1(1), ARG1(1), ARG2(1), CKB(1), CKMT1B(1), CKMT2(2), CPS1(4), GLUD1(2), NAGS(1), ODC1(1), OTC(1), PYCR1(2) 12840380 20 17 20 9 8 3 1 6 2 0 0.724 1.000 1.000 316 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 16 AKT1(3), CALM1(1), GNAS(2), GNB1(1), GNGT1(1), NFKB1(3), NOS3(2), NPPA(1), PIK3R1(2), RELA(3), SYT1(1) 11472699 20 15 19 7 4 7 1 6 2 0 0.633 1.000 1.000 317 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(2), GALNS(4), GLB1(2), HEXB(2), HGSNAT(1), HPSE(3), HYAL2(2), LCT(6), SPAM1(3) 14978624 25 16 25 9 13 5 0 5 2 0 0.443 1.000 1.000 318 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA2(2), ANXA4(2), ANXA5(1), ANXA6(2), CYP11A1(1), EDNRA(1), HPGD(1), HSD11B1(1), PLA2G4A(4), PRL(1), PTGER2(2), PTGER4(1), PTGIR(3), PTGIS(2), PTGS1(2), PTGS2(5), SCGB1A1(2), TBXAS1(2) 15290187 35 23 35 11 11 7 2 6 9 0 0.300 1.000 1.000 319 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 ABAT(1), ACADS(2), ACAT1(2), ACAT2(1), ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH5A1(1), ECHS1(1), EHHADH(5), GAD1(2), GAD2(9), HMGCL(1), L2HGDH(1), OXCT1(5), PDHA1(1), PDHA2(4), SDHB(2), SDS(1) 19013619 51 38 48 15 16 11 6 10 8 0 0.157 1.000 1.000 320 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(3), IKBKB(1), IL4(1), MAP3K1(5), MAP3K5(2), MAP4K5(1), NFKB1(3), RELA(3), TRAF2(5) 14232233 24 13 24 5 9 7 1 5 2 0 0.117 1.000 1.000 321 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 BLVRB(1), CP(5), CPOX(1), EPRS(4), HMBS(1), HMOX1(2), HMOX2(1), UGT1A1(2), UGT1A10(1), UGT1A4(1), UGT1A7(2), UGT1A9(2), UGT2B15(3), UGT2B4(1) 20247639 27 21 27 7 10 4 1 9 3 0 0.299 1.000 1.000 322 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 21 AKT1(3), BCR(2), GRB2(1), HRAS(4), JAK2(1), MAP2K4(4), MAP3K1(5), MYC(1), PIK3R1(2), RAF1(1), SOS1(4), STAT1(1), STAT5B(2) 19125791 31 23 28 8 8 7 5 6 5 0 0.141 1.000 1.000 323 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 19 ATR(3), BRCA1(1), BRCA2(8), FANCA(2), FANCC(1), FANCD2(2), FANCF(1), FANCG(1), HUS1(1), RAD17(2), RAD50(1), RAD51(1), RAD9A(1) 27409493 25 21 25 9 4 3 1 9 8 0 0.886 1.000 1.000 324 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 31 APC(10), ATF2(3), AXIN1(1), BMP10(1), BMP2(2), BMP4(1), BMP5(4), BMP7(3), BMPR1A(2), BMPR2(3), CHRD(1), DVL1(1), FZD1(2), GATA4(1), GSK3B(1), MAP3K7(2), MEF2C(3), NPPA(1), RFC1(5), TGFB2(2), TGFBR1(2), TGFBR3(1), WNT1(1) 25623623 53 35 53 14 11 10 9 8 15 0 0.141 1.000 1.000 325 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(2), CD3D(1), IL4(1), TGFB2(2), TGFBR1(2), TGFBR3(1), TOB1(1), TOB2(1) 7805360 11 9 11 7 1 3 4 2 1 0 0.868 1.000 1.000 326 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 12 AKT1(3), CHRNG(1), MUSK(3), PIK3R1(2), PTK2(3) 10312432 12 9 11 6 5 4 0 2 1 0 0.661 1.000 1.000 327 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 14 AKT1(3), AKT2(1), AKT3(1), CDKN1A(2), GRB2(1), HRAS(4), NTRK1(9), PIK3CD(5), SHC1(3), SOS1(4) 10183039 33 27 30 12 16 6 3 2 6 0 0.335 1.000 1.000 328 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 AKR1C3(1), ALOX12(1), ALOX12B(2), ALOX15(2), ALOX5(1), CYP2B6(3), CYP2C18(2), CYP2C19(4), CYP2C8(4), CYP2C9(3), CYP2E1(1), CYP2J2(1), CYP2U1(2), CYP4A11(1), CYP4A22(2), CYP4F2(2), CYP4F3(2), DHRS4(1), GPX2(2), GPX6(1), LTC4S(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PTGIS(2), PTGS1(2), PTGS2(5), TBXAS1(2) 28592782 59 40 59 11 18 11 6 14 10 0 0.0122 1.000 1.000 329 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(1), EPHA4(4), EPHB1(8), FYN(1), ITGA1(2), L1CAM(6), LYN(2), SELP(4) 11624514 28 22 28 11 7 4 4 9 4 0 0.586 1.000 1.000 330 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 17 CSF1(1), CSF1R(5), E2F1(3), ETS1(1), HDAC2(1), HDAC5(4), HRAS(4), NCOR2(7), RBL1(2), RBL2(2), SIN3A(1), SIN3B(2) 18770392 33 21 31 9 13 5 7 3 5 0 0.142 1.000 1.000 331 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM1(1), CAMK1(3), CAMK1G(2), FPR1(3), GNB1(1), GNGT1(1), HRAS(4), MAP2K3(1), MAP2K6(1), MAP3K1(5), MAPK1(1), NCF1(1), NCF2(3), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(3), PAK1(1), PIK3C2G(1), PLCB1(3), PPP3CA(2), PPP3CB(1), PPP3CC(2), RAC1(1), RAF1(1), RELA(3), SYT1(1) 28027341 52 34 50 14 14 9 7 13 9 0 0.186 1.000 1.000 332 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(1), ADH1B(1), ADH4(1), ADH6(3), ADHFE1(1), AKR1C1(1), AKR1C3(1), AKR1C4(1), ALDH1A3(2), ALDH3A1(1), ALDH3B1(1), CYP1A1(1), CYP1A2(1), CYP2B6(3), CYP2C18(2), CYP2C19(4), CYP2C8(4), CYP2C9(3), CYP2E1(1), CYP2F1(2), CYP2S1(2), CYP3A43(1), CYP3A7(1), EPHX1(3), GSTA2(2), GSTA3(1), GSTM2(2), GSTM3(1), GSTO2(1), GSTP1(1), MGST1(1), UGT1A1(2), UGT1A10(1), UGT1A4(1), UGT1A7(2), UGT1A9(2), UGT2A1(1), UGT2A3(3), UGT2B10(4), UGT2B11(2), UGT2B15(3), UGT2B17(1), UGT2B28(2), UGT2B4(1), UGT2B7(3) 42399490 79 55 79 15 20 9 11 29 10 0 0.0210 1.000 1.000 333 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AP2A1(1), CALM1(1), DNM1(2), EPN1(2), EPS15(2), NME1(1), PICALM(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), SYNJ1(3), SYNJ2(3), SYT1(1) 16003282 22 17 22 8 5 3 2 8 4 0 0.627 1.000 1.000 334 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH7A1(2), AOC2(3), AOC3(1), CNDP1(3), DPYD(3), DPYS(2), ECHS1(1), EHHADH(5), GAD1(2), GAD2(9), HIBCH(1), SRM(1) 19895388 40 33 40 13 15 7 5 7 6 0 0.322 1.000 1.000 335 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 29 ANPEP(2), GPX2(2), GSTA2(2), GSTA3(1), GSTM2(2), GSTM3(1), GSTO2(1), GSTP1(1), MGST1(1) 12674012 13 10 13 5 4 3 1 5 0 0 0.590 1.000 1.000 336 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(2), GNAS(2), PLCE1(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), RAP2B(1) 10870168 16 13 16 9 4 1 1 9 1 0 0.939 1.000 1.000 337 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM1(1), EGR3(1), MAP3K1(5), MYC(1), NFATC1(2), NFATC2(2), NFKB1(3), PLCG1(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), RELA(3), SYT1(1) 20608502 32 17 32 9 9 7 3 9 4 0 0.202 1.000 1.000 338 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 18 AKT1(3), APAF1(2), CASP9(1), EIF2S1(1), PRKCA(2), PTK2(3), PXN(1), STAT1(1), TLN1(4) 15002814 18 13 17 8 4 4 1 6 3 0 0.734 1.000 1.000 339 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(1), GRB2(1), HRAS(4), IL3RA(3), JAK2(1), RAF1(1), SHC1(3), SOS1(4), STAT5B(2) 13052662 20 15 18 8 7 4 5 0 4 0 0.475 1.000 1.000 340 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM1(1), CAMK1(3), CAMK1G(2), CAMK2A(1), CAMK2D(2), CAMK4(4), HDAC5(4), MEF2A(1), MEF2C(3), MEF2D(1), PPARA(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), SYT1(1) 14817884 30 18 30 10 11 4 1 9 5 0 0.467 1.000 1.000 341 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 13 APC(10), AXIN1(1), CREBBP(8), DVL1(1), EP300(7), FZD1(2), GSK3B(1), HDAC1(1), LEF1(2), PITX2(3), TRRAP(5), WNT1(1) 23298491 42 31 42 14 14 5 6 6 11 0 0.331 1.000 1.000 342 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 DRD2(1), GRM1(9), PLCB1(3), PPP1CA(1), PPP2CA(2), PPP3CA(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1) 11835042 25 19 24 10 8 5 1 7 4 0 0.657 1.000 1.000 343 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(2), ASPH(2), CREB1(1), EP300(7), HIF1A(2), NOS3(2), P4HB(1), VHL(3) 12480708 20 12 20 8 10 4 1 3 2 0 0.586 1.000 1.000 344 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(1), ACADSB(3), ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), AOC2(3), AOC3(1), CNDP1(3), DPYD(3), DPYS(2), ECHS1(1), EHHADH(5), GAD1(2), GAD2(9), SDS(1) 21433687 46 36 45 14 16 8 7 7 8 0 0.233 1.000 1.000 345 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 23 BMPR1B(2), CEBPB(1), EGR1(3), FSHR(2), GJA4(2), INHA(1), LHCGR(1), MLH1(2), MSH5(1), NCOR1(8), NRIP1(4), PGR(2), PRLR(1), PTGER2(2), VDR(2), ZP2(3) 20943798 37 27 37 12 9 6 4 4 14 0 0.535 1.000 1.000 346 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM1(1), DLG4(3), GRIN1(3), GRIN2A(11), GRIN2B(8), GRIN2C(3), NOS1(3), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), PRKCA(2), SYT1(1) 18780418 47 33 47 17 17 6 1 18 5 0 0.400 1.000 1.000 347 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 17 ABL1(5), BRCA1(1), CDKN1A(2), MDM2(1), NFKB1(3), RAD50(1), RAD51(1), RBBP8(1), RELA(3), TP73(2) 16809984 20 8 20 5 6 4 3 4 3 0 0.376 1.000 1.000 348 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(4), EGF(3), EGFR(3), HGS(2), TF(1), TFRC(1) 9503241 14 10 14 8 1 1 3 8 1 0 0.949 1.000 1.000 349 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 36 BTK(1), CALM1(1), FCER1A(1), GRB2(1), HRAS(4), LYN(2), MAP2K4(4), MAP2K7(4), MAP3K1(5), MAPK1(1), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), PAK2(2), PIK3R1(2), PLA2G4A(4), PLCG1(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), RAF1(1), SHC1(3), SOS1(4), SYK(2), SYT1(1), VAV1(3) 30066280 58 41 56 16 20 8 5 14 11 0 0.225 1.000 1.000 350 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 35 ANPEP(2), GPX2(2), GPX6(1), GSR(1), GSTA2(2), GSTA3(1), GSTM2(2), GSTM3(1), GSTO2(1), GSTP1(1), MGST1(1), OPLAH(2) 15582803 17 12 17 7 6 4 1 5 1 0 0.565 1.000 1.000 351 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 ALDOC(3), FBP1(2), FBP2(1), GCK(4), GMDS(1), GMPPB(3), HK1(2), HK2(4), HK3(4), KHK(1), MPI(1), PFKFB1(2), PFKFB4(1), PFKM(3), PFKP(3), PMM1(1) 17487806 36 22 36 13 16 2 5 8 5 0 0.345 1.000 1.000 352 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSB(2), ARSD(1), ARSE(2), ASAH1(1), GAL3ST1(2), GALC(1), GLB1(2), LCT(6), NEU1(1), NEU2(2), NEU4(2), PPAP2A(1), PPAP2B(1), SMPD2(2), SPTLC1(1), SPTLC2(1) 17724889 28 23 28 10 12 3 3 7 3 0 0.412 1.000 1.000 353 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(1), CA1(1), CA12(1), CA14(2), CA2(3), CA3(1), CA4(2), CA5A(1), CA6(1), CA8(4), CA9(2), CPS1(4), CTH(2), GLUD1(2), GLUL(1), HAL(2) 14022589 30 26 30 10 8 6 1 10 5 0 0.499 1.000 1.000 354 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CREBBP(8), DUSP1(1), EP300(7), IKBKB(1), MAP2K3(1), MAP2K6(1), MAP3K7(2), NFKB1(3), RELA(3), TGFBR1(2), TLR2(2), TNF(1) 21833709 32 22 32 9 10 7 5 7 3 0 0.260 1.000 1.000 355 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 ADRB1(1), AKT1(3), APC(10), ASAH1(1), CAV3(1), DAG1(2), DLG4(3), EPHB2(4), GNAI1(2), ITPR1(4), ITPR2(8), ITPR3(6), KCNJ5(2), MAPK1(1), PITX2(3), PTX3(1), RAC1(1), RHO(1), RYR1(20) 33703560 74 56 73 19 33 7 4 13 17 0 0.0639 1.000 1.000 356 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 19 ACO1(1), ACO2(1), CS(3), DLD(2), FH(3), IDH3A(1), IDH3B(1), MDH1(1), PC(2), SDHA(3), SDHB(2), SUCLA2(1) 14536055 21 12 21 7 3 5 4 5 4 0 0.371 1.000 1.000 357 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 EPOR(1), GRB2(1), HRAS(4), JAK2(1), PLCG1(1), RAF1(1), SHC1(3), SOS1(4), STAT5B(2) 15744634 18 15 16 9 8 3 4 0 3 0 0.727 1.000 1.000 358 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 25 ADCY1(2), AKT1(3), CAMK2A(1), CAMK2D(2), CREB1(1), GNAS(2), GRB2(1), HRAS(4), MAPK1(1), PIK3R1(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), PRKCA(2), RAC1(1), RPS6KA1(2), RPS6KA5(3), SOS1(4) 19842557 38 27 35 12 12 5 6 11 4 0 0.402 1.000 1.000 359 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 29 AKT1(3), AKT2(1), AKT3(1), ANKRD6(2), APC(10), AXIN1(1), AXIN2(5), DACT1(4), DKK1(3), DKK2(2), DVL1(1), GSK3A(3), GSK3B(1), LRP1(12), MVP(2), NKD2(1), PTPRA(5), WIF1(2) 28405081 59 37 58 14 17 14 6 8 14 0 0.0327 1.000 1.000 360 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(2), ACAA2(1), ACADS(2), ACADSB(3), ACADVL(1), ACAT1(2), ACAT2(1), ACOX1(2), ACOX3(1), ACSL1(3), ACSL5(1), ACSL6(3), ADH1A(1), ADH1B(1), ADH4(1), ADH6(3), ADHFE1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH7A1(2), CPT1A(1), CPT1B(2), CPT1C(5), CPT2(2), CYP4A11(1), CYP4A22(2), ECHS1(1), EHHADH(5), GCDH(1), HADH(3), HADHB(1), HSD17B4(3) 36136855 64 42 63 15 24 8 8 12 12 0 0.0418 1.000 1.000 361 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(2), BIRC2(1), CASP10(1), CASP8(1), CASP9(1), CFLAR(2), DFFA(4), LMNA(4), NFKB1(3), RELA(3), RIPK1(1), SPTAN1(2), TNFRSF10A(1), TNFRSF10B(2), TNFSF12(1), TRAF2(5) 24522172 34 19 34 8 9 11 2 10 2 0 0.154 1.000 1.000 362 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 AKT1(3), AKT2(1), AKT3(1), DAG1(2), ITPKB(2), ITPR1(4), ITPR2(8), ITPR3(6), NFKB1(3), NFKBIB(2), NFKBIE(1), NFKBIL1(1), PDK1(2), PHKA2(2), PIK3CB(3), PITX2(3), PLD1(3), PLD2(2), VN1R1(2) 33003130 51 37 50 10 13 13 3 14 8 0 0.0309 1.000 1.000 363 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 25 GRB2(1), HRAS(4), JAK1(6), MAP2K4(4), MAP3K1(5), PDGFA(2), PDGFRA(3), PIK3R1(2), PLCG1(1), PRKCA(2), RAF1(1), RASA1(1), SHC1(3), SOS1(4), STAT1(1), STAT3(6) 24057236 46 32 44 15 16 8 6 9 7 0 0.300 1.000 1.000 364 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT10(5), GALNT2(1), GALNT3(5), GALNT4(1), GALNT8(2), GCNT1(2), ST3GAL1(2), WBSCR17(2) 10631557 20 13 20 9 9 2 0 7 2 0 0.763 1.000 1.000 365 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(3), CREB1(1), DUSP1(1), EEF2K(5), EIF4E(1), MAP2K3(1), MAP2K4(4), MAP2K6(1), MAP3K10(4), MAP3K4(3), MAP3K5(2), MAP3K7(2), MAPK1(1), MAPK12(1), MAPK13(1), MAPKAPK5(1), NFKB1(3), TRAF6(2) 24427549 37 21 36 12 14 8 2 6 7 0 0.327 1.000 1.000 366 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAS1(3), ALAS2(1), BLVRB(1), COX15(2), CP(5), CPOX(1), EARS2(1), EPRS(4), FTMT(2), HMBS(1), HMOX1(2), HMOX2(1), MMAB(1), UGT1A1(2), UGT1A10(1), UGT1A4(1), UGT1A7(2), UGT1A9(2), UGT2A1(1), UGT2A3(3), UGT2B10(4), UGT2B11(2), UGT2B15(3), UGT2B17(1), UGT2B28(2), UGT2B4(1), UGT2B7(3) 31098922 53 36 53 15 17 7 4 18 7 0 0.282 1.000 1.000 367 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 ALDOC(3), FBP1(2), FBP2(1), FUK(1), GMDS(1), GMPPB(3), HK1(2), HK2(4), HK3(4), KHK(1), LHPP(1), MPI(1), MTMR2(4), MTMR6(1), PFKFB1(2), PFKFB4(1), PFKL(2), PFKM(3), PFKP(3), PGM2(3), PMM1(1), RDH12(1), TSTA3(5) 27168496 50 30 50 17 17 4 8 12 9 0 0.267 1.000 1.000 368 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH1A(1), ADH1B(1), ADH4(1), ADH6(3), ADHFE1(1), ALDH1A3(2), ALDH3A1(1), ALDH3B1(1), AOC2(3), AOC3(1), AOX1(2), DBH(5), FAH(1), GOT1(2), GOT2(1), HGD(1), HPD(2), MAOA(2), MAOB(2), PNMT(1), TPO(5), TYR(2) 23251996 41 36 41 13 14 7 3 10 7 0 0.306 1.000 1.000 369 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(2), CALM1(1), CALML3(1), CALML6(1), CAMK2A(1), CAMK2D(2), CLCA1(1), CLCA2(2), CLCA4(2), CNGA3(1), CNGA4(4), CNGB1(1), GNAL(3), GUCA1A(1), PDE1C(3), PRKACA(2), PRKG1(1), PRKX(2) 22469928 31 27 31 11 10 5 4 5 7 0 0.361 1.000 1.000 370 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 49 ACOX1(2), CD36(1), CITED2(1), CPT1B(2), CREBBP(8), DUSP1(1), EHHADH(5), EP300(7), HSD17B4(3), LPL(1), MAPK1(1), ME1(3), MRPL11(1), MYC(1), NCOA1(1), NCOR1(8), NCOR2(7), NR1H3(1), NR2F1(1), NRIP1(4), PDGFA(2), PIK3R1(2), PPARA(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), PRKCA(2), PTGS2(5), RB1(3), RELA(3), RXRA(2), SP1(2), STAT5B(2), TNF(1) 44928749 92 58 92 21 27 18 9 16 21 1 0.0171 1.000 1.000 371 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(3), ATP6V0A1(3), ATP6V0B(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1C2(5), ATP6V1F(1), ATP6V1H(1), ATP7A(2), ATP7B(2), COX7A1(2), COX7C(1), NDUFA10(2), NDUFA5(1), NDUFB7(1), NDUFS2(2), NDUFV1(1), SDHA(3), SDHB(2), SHMT1(1), UQCRC1(2) 28155279 41 28 41 11 8 12 5 11 5 0 0.167 1.000 1.000 372 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(1), CASP8(1), DFFA(4), LMNA(4), LMNB2(2), MADD(1), MAP2K4(4), MAP3K1(5), MAP3K7(2), PAK1(1), PAK2(2), PRKDC(11), RB1(3), RIPK1(1), SPTAN1(2), TNF(1), TNFRSF1A(1), TRAF2(5) 28392344 51 32 51 14 18 12 3 10 7 1 0.215 1.000 1.000 373 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AADAC(1), ABAT(1), ACADS(2), ACAT1(2), ACAT2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH5A1(1), ALDH7A1(2), DDHD1(5), ECHS1(1), EHHADH(5), GAD1(2), GAD2(9), HADH(3), HMGCL(1), HMGCS1(1), HMGCS2(1), HSD17B4(3), ILVBL(3), L2HGDH(1), OXCT1(5), PDHA1(1), PDHA2(4), RDH12(1) 29827275 62 46 60 16 21 10 7 14 10 0 0.0789 1.000 1.000 374 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 41 CALM1(1), CD3D(1), FYN(1), GRB2(1), HRAS(4), MAP2K4(4), MAP3K1(5), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(3), PIK3R1(2), PLCG1(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKCA(2), PTPN7(4), RAC1(1), RAF1(1), RASA1(1), RELA(3), SHC1(3), SOS1(4), SYT1(1), VAV1(3), ZAP70(6) 33572775 63 37 61 20 23 10 8 13 9 0 0.249 1.000 1.000 375 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(3), BCR(2), GRB2(1), HRAS(4), LYN(2), MAP3K1(5), MAPK1(1), MAPK8IP3(4), PAPPA(3), RAC1(1), RPS6KA1(2), SHC1(3), SOS1(4), SYK(2), VAV1(3), VAV2(3), VAV3(4) 23509829 47 35 45 17 17 7 8 9 6 0 0.400 1.000 1.000 376 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 32 AKT1(3), APC(10), AR(2), ASAH1(1), CCL15(1), DAG1(2), EGFR(3), GNA11(1), GNAI1(2), ITPKB(2), ITPR1(4), ITPR2(8), ITPR3(6), KCNJ5(2), MAPK1(1), PHKA2(2), PIK3CD(5), PIK3R1(2), PITX2(3), PTX3(1), RAF1(1) 36443517 62 50 61 19 20 8 3 14 17 0 0.311 1.000 1.000 377 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(4), ANAPC2(4), ANAPC4(1), ANAPC5(3), ANAPC7(1), BTRC(3), CDC16(1), CDC20(2), CDC23(3), CDC27(2), CUL1(2), CUL2(4), CUL3(5), FBXW11(2), FZR1(4), ITCH(2), SMURF1(1), SMURF2(1), TCEB2(1), UBA1(2), UBE2C(1), VHL(3), WWP1(3), WWP2(1) 29561326 56 35 55 12 10 9 12 14 11 0 0.0685 1.000 1.000 378 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ALDH1A3(2), ALDH3A1(1), ALDH3B1(1), AOC2(3), AOC3(1), EPX(4), ESCO1(5), ESCO2(1), GOT1(2), GOT2(1), HPD(2), LPO(2), MAOA(2), MAOB(2), MPO(3), NAT6(1), SH3GLB1(1), TPO(5) 25108403 39 31 39 13 12 6 3 12 6 0 0.537 1.000 1.000 379 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(3), AKT2(1), AKT3(1), ARHGEF11(2), DLG4(3), GNA13(2), LPA(5), MAP2K4(4), MAP3K1(5), MAP3K5(2), NFKB1(3), NFKBIB(2), NFKBIE(1), NFKBIL1(1), PDK1(2), PHKA2(2), PI3(1), PIK3CB(3), PLD1(3), PLD2(2), PTK2(3), RDX(1), ROCK1(5), ROCK2(1), SERPINA4(1), TBXA2R(5) 36201850 64 42 62 17 18 13 5 15 13 0 0.125 1.000 1.000 380 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 65 APAF1(2), BCL2L11(1), BIRC2(1), BIRC5(2), CASP1(2), CASP10(1), CASP8(1), CASP9(1), DFFA(4), FAS(1), FASLG(1), HELLS(1), IKBKB(1), IRF2(1), IRF3(1), IRF4(4), IRF5(1), IRF6(3), MAP2K4(4), MAP3K1(5), MDM2(1), MYC(1), NFKB1(3), NFKBIB(2), NFKBIE(1), PRF1(2), RELA(3), RIPK1(1), TNF(1), TNFRSF10B(2), TNFRSF1A(1), TNFRSF1B(1), TNFRSF21(7), TP73(2), TRAF1(1), TRAF2(5) 41514315 72 44 72 19 19 15 4 23 11 0 0.153 1.000 1.000 381 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(1), ACACA(7), ACADSB(3), ACAT1(2), ACAT2(1), ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH6A1(2), ECHS1(1), EHHADH(5), LDHB(1), LDHC(1), MUT(3), SDS(1), SUCLA2(1) 24448002 41 27 40 12 11 5 7 11 6 1 0.335 1.000 1.000 382 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(3), ARSB(2), FUCA1(1), FUCA2(1), GALNS(4), GLB1(2), HEXB(2), HGSNAT(1), HPSE(3), HYAL2(2), LCT(6), MAN2B1(3), MAN2B2(2), MAN2C1(3), NEU1(1), NEU2(2), NEU4(2), SPAM1(3) 25214885 43 27 43 14 22 6 1 7 7 0 0.302 1.000 1.000 383 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 40 APAF1(2), BIRC2(1), CASP8(1), CASP9(1), FAS(1), FASLG(1), MAP2K4(4), MAP3K1(5), MCL1(1), MDM2(1), MYC(1), NFKB1(3), PARP1(2), PRF1(2), RELA(3), RIPK1(1), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRAF1(1), TRAF2(5) 26845760 39 23 39 14 9 12 2 12 4 0 0.466 1.000 1.000 384 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSD(1), ARSE(2), ASAH1(1), B4GALT6(3), CERK(1), DEGS1(1), DEGS2(2), ENPP7(3), GAL3ST1(2), GALC(1), GLB1(2), LCT(6), NEU1(1), NEU2(2), NEU4(2), PPAP2A(1), PPAP2B(1), SGMS1(1), SMPD2(2), SMPD3(1), SMPD4(1), SPHK1(1), SPHK2(1), SPTLC1(1), SPTLC2(1) 26097497 41 24 41 13 22 5 4 5 5 0 0.158 1.000 1.000 385 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 CHIA(1), CHIT1(1), CMAS(1), CTBS(1), CYB5R1(1), GFPT2(2), GNE(1), GNPDA1(1), GNPNAT1(1), HEXB(2), HK1(2), HK2(4), HK3(4), LHPP(1), MTMR2(4), MTMR6(1), NAGK(1), NANS(1), PGM3(1), UAP1(1) 21093853 32 17 32 10 9 6 3 9 5 0 0.400 1.000 1.000 386 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 22 IMPA1(2), INPP4A(2), INPP4B(3), INPP5A(1), INPPL1(1), ITPKB(2), OCRL(3), PIK3C2A(2), PIK3C2B(5), PIK3C2G(1), PIK3CB(3), PIK3CG(7), PLCB1(3), PLCB2(1), PLCB4(8), PLCD1(1), PLCG1(1), PLCG2(3) 31250630 49 30 49 11 16 13 4 11 5 0 0.0552 1.000 1.000 387 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 24 ARNT(2), EIF2B1(1), EIF2B2(1), EIF2B3(1), EIF2B5(1), EIF2S1(1), FLT1(5), FLT4(4), HIF1A(2), HRAS(4), KDR(7), NOS3(2), PIK3R1(2), PLCG1(1), PRKCA(2), PTK2(3), PXN(1), SHC1(3), VHL(3) 23384284 46 29 44 16 17 7 5 6 10 1 0.488 1.000 1.000 388 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 31 ACTR3(1), AKT1(3), ANGPTL2(1), DAG1(2), DGKA(1), ETFA(1), ITGA9(4), ITPKB(2), ITPR1(4), ITPR2(8), ITPR3(6), MAPK1(1), NR1I3(2), PAK1(1), PDE3A(2), PDE3B(3), PI3(1), PIK3C2G(1), PIK3CD(5), PIK3R1(2), PSME1(1), RIPK3(1) 34160749 53 41 52 14 16 10 3 12 12 0 0.226 1.000 1.000 389 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(2), ACAA2(1), ACADS(2), ACADSB(3), ACAT1(2), ACAT2(1), ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH6A1(2), AOX1(2), BCAT1(1), BCKDHA(1), ECHS1(1), EHHADH(5), HADHB(1), HMGCL(1), IVD(2), MCCC1(1), MUT(3), OXCT1(5), SDS(1) 26574738 49 35 47 16 14 7 8 12 8 0 0.409 1.000 1.000 390 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(2), COL4A2(4), COL4A3(2), COL4A4(3), COL4A5(3), COL4A6(4), F10(3), F11(4), F12(1), F2(2), F2R(2), F5(5), F8(1), FGA(5), FGB(2), FGG(1), KLKB1(2), PROC(3), PROS1(3), SERPINC1(2), SERPING1(2) 32528253 56 43 56 21 19 10 2 16 9 0 0.642 1.000 1.000 391 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(3), AR(2), ESR1(2), NR1D1(3), NR1D2(2), NR1H3(1), NR1I2(2), NR1I3(2), NR2E1(1), NR2F1(1), NR2F2(1), NR4A1(1), NR4A2(2), NR5A2(1), PGR(2), PPARA(2), PPARD(4), PPARG(1), RARA(1), RARB(3), RARG(1), ROR1(1), RORA(1), RXRA(2), RXRB(2), RXRG(2), THRA(6), VDR(2) 30663004 54 37 53 13 27 8 6 8 5 0 0.0424 1.000 1.000 392 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(3), CALM1(1), GRB2(1), HRAS(4), MAP2K3(1), MAP2K4(4), MAP3K1(5), MAPK1(1), PAK1(1), PLCG1(1), PRKCA(2), RAC1(1), RAF1(1), SHC1(3), SOS1(4), SYT1(1) 20926316 34 24 32 12 14 5 5 5 5 0 0.426 1.000 1.000 393 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(2), IKBKB(1), IRAK1(1), LY96(1), MAP2K3(1), MAP2K4(4), MAP2K6(1), MAP3K1(5), MAP3K7(2), NFKB1(3), PPARA(2), RELA(3), TIRAP(1), TLR10(1), TLR2(2), TLR4(2), TLR7(3), TLR9(1), TRAF6(2) 26685518 38 21 37 13 15 8 2 9 4 0 0.295 1.000 1.000 394 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(2), AASDH(2), AASDHPPT(1), AASS(3), ACAT1(2), ACAT2(1), ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), BBOX1(2), DOT1L(4), ECHS1(1), EHHADH(5), EHMT1(1), EHMT2(3), GCDH(1), PLOD1(2), PLOD3(3), SDS(1), SHMT1(1), SHMT2(1) 27228611 48 36 47 14 14 6 7 11 10 0 0.249 1.000 1.000 395 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(1), ALOX12(1), ALOX15(2), ALOX5(1), CYP4F2(2), CYP4F3(2), EPX(4), LPO(2), MPO(3), PLA2G2A(1), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PRDX1(1), PTGIS(2), PTGS1(2), PTGS2(5), TBXAS1(2), TPO(5) 20464935 43 29 43 15 17 8 1 12 5 0 0.336 1.000 1.000 396 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(1), CALR(1), CD4(1), CD8A(1), CD8B(2), CIITA(3), CREB1(1), CTSS(1), HLA-A(1), HLA-DMA(1), HLA-DMB(1), HLA-DOA(1), HLA-DQA2(1), HLA-DRA(1), HLA-DRB5(1), HLA-F(1), HLA-G(2), HSP90AA1(3), HSP90AB1(2), HSPA5(1), IFI30(1), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(2), KIR3DL1(2), KLRC1(1), LGMN(1), NFYA(1), NFYC(3), PDIA3(1), PSME1(1), RFX5(1), RFXAP(1), TAP1(3), TAP2(1) 34126564 50 34 50 13 16 8 7 10 9 0 0.104 1.000 1.000 397 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(1), AKR1D1(1), ARSD(1), ARSE(2), CARM1(2), CYP11B1(1), CYP11B2(2), CYP19A1(2), HEMK1(1), HSD11B1(1), HSD17B2(1), HSD17B3(1), HSD17B7(2), HSD3B1(2), HSD3B2(2), LCMT1(1), LCMT2(1), METTL6(1), PRMT3(2), PRMT5(2), PRMT7(1), PRMT8(1), STS(1), SULT1E1(2), UGT1A1(2), UGT1A10(1), UGT1A4(1), UGT1A7(2), UGT1A9(2), UGT2A1(1), UGT2A3(3), UGT2B10(4), UGT2B11(2), UGT2B15(3), UGT2B17(1), UGT2B28(2), UGT2B4(1), UGT2B7(3) 37005051 62 45 61 17 12 11 8 20 11 0 0.200 1.000 1.000 398 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(1), ACAA1(2), ACAA2(1), ACADS(2), ACAT1(2), ACAT2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH6A1(2), ALDH7A1(2), AOX1(2), BCAT1(1), BCAT2(1), BCKDHA(1), DBT(1), DLD(2), ECHS1(1), EHHADH(5), HADH(3), HADHB(1), HIBCH(1), HMGCL(1), HMGCS1(1), HMGCS2(1), HSD17B4(3), IVD(2), MCCC1(1), MUT(3), OXCT1(5) 31705200 55 40 54 17 17 10 6 13 9 0 0.304 1.000 1.000 399 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 AGXT(1), AGXT2(2), ALAS1(3), ALAS2(1), AMT(1), AOC2(3), AOC3(1), BHMT(2), CBS(1), CHDH(4), CTH(2), DAO(1), DLD(2), DMGDH(1), GARS(1), GCAT(1), GLDC(3), MAOA(2), MAOB(2), PHGDH(1), PIPOX(2), PISD(1), PSAT1(1), RDH12(1), SARDH(6), SARS(2), SDS(1), SHMT1(1), SHMT2(1), TARS(3), TARS2(3) 31223027 57 34 57 17 21 13 0 11 11 1 0.264 1.000 1.000 400 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 29 AKT1(3), CABIN1(1), CALM1(1), CAMK1(3), CAMK1G(2), HDAC5(4), IGF1R(4), MAP2K6(1), MEF2A(1), MEF2C(3), MEF2D(1), NFATC1(2), NFATC2(2), PIK3R1(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), SYT1(1) 23901312 36 24 35 14 11 5 4 11 5 0 0.569 1.000 1.000 401 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(1), CARM1(2), CREBBP(8), EP300(7), ERCC3(1), ESR1(2), GRIP1(5), GTF2E1(1), HDAC1(1), HDAC2(1), HDAC3(2), HDAC4(3), HDAC5(4), HDAC6(4), MEF2C(3), NCOR2(7), NRIP1(4), PELP1(2), POLR2A(6) 33447832 64 37 64 23 19 14 9 12 10 0 0.362 1.000 1.000 402 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(6), AMY2A(1), AMY2B(2), ENPP1(3), ENPP3(2), G6PC(1), GAA(1), GANAB(3), GBE1(2), GCK(4), GYS1(4), HK1(2), HK2(4), HK3(4), MGAM(4), PGM3(1), PYGB(4), PYGL(4), PYGM(1), RNPC3(1), SI(6), UGDH(2), UGT1A1(2), UGT1A10(1), UGT1A4(1), UGT1A7(2), UGT1A9(2), UGT2B15(3), UGT2B4(1) 41985061 74 45 73 18 20 13 11 16 14 0 0.0897 1.000 1.000 403 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 61 APAF1(2), ATR(3), BAI1(7), CASP8(1), CASP9(1), CCNB2(1), CCND3(1), CCNE2(1), CCNG1(1), CCNG2(1), CDKN1A(2), CDKN2A(1), EI24(1), FAS(1), GTSE1(2), IGFBP3(1), MDM2(1), MDM4(1), PERP(1), PPM1D(1), RCHY1(2), RFWD2(1), RRM2(1), SERPINB5(4), SESN1(2), SESN2(4), SESN3(3), STEAP3(1), THBS1(3), TNFRSF10B(2), TP73(2), TSC2(7) 42212998 63 44 63 17 25 6 5 18 9 0 0.169 1.000 1.000 404 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 40 AKT1(3), ASAH1(1), CREB1(1), CREBBP(8), DAG1(2), EGR1(3), EGR3(1), FRS2(1), MAP1B(2), MAP2K4(4), MAP2K7(4), MAPK1(1), MAPK8IP3(4), NTRK1(9), OPN1LW(1), PIK3C2G(1), PIK3CD(5), PIK3R1(2), PTPN11(1), SHC1(3), TERF2IP(1) 34819866 58 41 57 21 27 9 1 11 10 0 0.401 1.000 1.000 405 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(1), AARS2(2), CARS(4), CARS2(2), DARS2(1), EARS2(1), EPRS(4), FARS2(2), FARSB(2), GARS(1), HARS(1), IARS(2), IARS2(1), KARS(2), LARS(3), LARS2(2), MARS2(1), NARS2(1), PARS2(3), QARS(1), RARS2(1), SARS(2), TARS(3), TARS2(3), VARS(4), VARS2(4), WARS(1), WARS2(2), YARS(3), YARS2(3) 40001155 63 40 63 14 25 11 6 14 7 0 0.0812 1.000 1.000 406 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT(1), AGXT2(2), ALAS1(3), ALAS2(1), AMT(1), AOC2(3), AOC3(1), BHMT(2), CBS(1), CHDH(4), CPT1B(2), CTH(2), DAO(1), DLD(2), DMGDH(1), GARS(1), GCAT(1), GLDC(3), MAOA(2), MAOB(2), PISD(1), PLCB2(1), PLCG1(1), PLCG2(3), SARDH(6), SARS(2), SHMT1(1), SHMT2(1), TARS(3) 30685068 55 35 55 16 17 10 2 13 12 1 0.293 1.000 1.000 407 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(7), ACAT1(2), ACAT2(1), ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), DLAT(1), DLD(2), HAGH(1), LDHB(1), LDHC(1), LDHD(1), MDH1(1), ME1(3), ME2(1), ME3(1), PC(2), PDHA1(1), PDHA2(4), PKLR(1) 27220442 43 28 41 10 9 8 7 11 7 1 0.108 1.000 1.000 408 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(1), ADH1B(1), ADH4(1), ADH6(3), ADHFE1(1), AGPAT2(1), AGPAT3(2), AGPAT4(2), AKR1A1(2), ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), DGAT1(1), DGKA(1), DGKB(3), DGKD(4), DGKE(1), DGKH(2), DGKQ(1), DGKZ(3), GK(1), GLB1(2), LCT(6), LIPC(1), LIPG(5), LPL(1), PNLIP(4), PNLIPRP1(1), PPAP2A(1), PPAP2B(1) 35279292 65 43 64 24 22 8 7 16 12 0 0.417 1.000 1.000 409 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(2), BCL2A1(1), CASP1(2), CASP10(1), CASP8(1), CASP9(1), CD40(1), CD40LG(1), DAXX(2), DFFA(4), FAS(1), FASLG(1), IKBKE(1), MCL1(1), NFKB1(3), NTRK1(9), PTPN13(1), RIPK1(1), TFG(1), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRAF1(1), TRAF2(5), TRAF6(2) 31959497 46 27 46 10 18 13 2 8 5 0 0.0394 1.000 1.000 410 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 B4GALT1(2), B4GALT2(2), FBP2(1), G6PC(1), GAA(1), GALK1(1), GALK2(1), GALT(1), GANAB(3), GCK(4), GLB1(2), HK1(2), HK2(4), HK3(4), LCT(6), MGAM(4), PFKM(3), PFKP(3), PGM3(1) 23846052 46 26 46 17 24 5 3 9 5 0 0.339 1.000 1.000 411 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(3), ATP8A1(1), AVPR1A(3), AVPR1B(2), BDKRB1(3), BDKRB2(2), BRS3(1), C3AR1(2), CCKAR(2), CCKBR(2), CCR1(3), CCR2(3), CCR3(1), CCR4(1), CCR5(2), CCR6(1), CCR7(3), CXCR6(1), EDNRA(1), FPR1(3), FSHR(2), GALT(1), GHSR(1), GNRHR(4), GRPR(1), LHCGR(1), MC3R(2), MC4R(1), MC5R(1), NMBR(1), NPY1R(2), NPY2R(2), NPY5R(2), NTSR1(3), NTSR2(3), OPRD1(1), OPRK1(1), OPRL1(2), OPRM1(2), SSTR1(5), SSTR2(1), SSTR3(2), SSTR4(3), TACR1(2), TACR2(1), TACR3(2), TRHR(1), TSHR(1) 38530637 91 58 90 27 39 15 4 26 7 0 0.0446 1.000 1.000 412 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 33 AKT1(3), AKT2(1), AKT3(1), ASAH1(1), DAG1(2), DRD2(1), EGFR(3), EPHB2(4), GRB2(1), ITPKB(2), ITPR1(4), ITPR2(8), ITPR3(6), KCNJ5(2), MAPK1(1), PI3(1), PIK3CB(3), PITX2(3), PLCB1(3), PLCB2(1), PLCB4(8), RAF1(1), SHC1(3), SOS1(4), SOS2(1), STAT3(6), TERF2IP(1) 41963910 75 58 74 24 20 16 4 24 11 0 0.342 1.000 1.000 413 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 37 AKT1(3), ATF2(3), DLD(2), DUSP8(3), GAB1(1), GCK(4), MAP2K4(4), MAP2K7(4), MAP3K1(5), MAP3K10(4), MAP3K11(1), MAP3K12(3), MAP3K13(3), MAP3K3(1), MAP3K4(3), MAP3K5(2), MAP3K7(2), MAP3K9(4), NFATC3(1), PAPPA(3), SHC1(3), TRAF6(2) 36490119 61 34 60 17 20 15 3 10 13 0 0.122 1.000 1.000 414 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 ANKHD1(2), EEF1A2(2), EEF1G(1), EEF2(2), EEF2K(5), EIF2AK3(4), EIF2B1(1), EIF2B2(1), EIF2B3(1), EIF2B5(1), EIF2S1(1), EIF4A1(1), EIF4E(1), EIF4G1(4), EIF4G3(6), EIF5(2), EIF5A(2), EIF5B(1), ETF1(2), PABPC3(1), SLC35A4(1) 32254089 42 31 42 14 12 3 4 12 11 0 0.510 1.000 1.000 415 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 66 ACAA1(2), ACOX1(2), ACOX2(2), ACOX3(1), ACSL1(3), ACSL5(1), ACSL6(3), ADIPOQ(1), APOA5(1), AQP7(2), CD36(1), CPT1A(1), CPT1B(2), CPT1C(5), CPT2(2), CYP4A11(1), CYP4A22(2), CYP7A1(1), CYP8B1(1), DBI(1), EHHADH(5), FABP2(1), FABP4(1), FABP6(2), FADS2(1), GK(1), HMGCS2(1), ILK(1), LPL(1), ME1(3), NR1H3(1), PCK2(2), PDPK1(1), PLTP(1), PPARA(2), PPARD(4), PPARG(1), RXRA(2), RXRB(2), RXRG(2), SCD(2), SCP2(3), SLC27A1(3), SLC27A5(2), SLC27A6(2), SORBS1(3), UBC(1), UCP1(1) 47193356 87 52 85 20 32 15 8 16 16 0 0.0209 1.000 1.000 416 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(5), ACTB(1), ACTG1(2), ARHGEF2(5), ARPC5(1), ARPC5L(1), CD14(2), CDH1(4), CLDN1(1), CTTN(1), FYN(1), HCLS1(1), KRT18(1), LY96(1), NCL(1), PRKCA(2), RHOA(2), ROCK1(5), ROCK2(1), TLR4(2), TLR5(2), TUBA1A(1), TUBA3C(5), TUBA3E(1), TUBA4A(2), TUBA8(1), TUBAL3(1), TUBB1(2), TUBB2B(1), TUBB3(1), TUBB6(1), TUBB8(2), WAS(2), YWHAQ(2), YWHAZ(1) 37496942 65 43 63 19 15 10 5 23 12 0 0.280 1.000 1.000 417 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ABL1(5), ACTB(1), ACTG1(2), ARHGEF2(5), ARPC5(1), ARPC5L(1), CD14(2), CDH1(4), CLDN1(1), CTTN(1), FYN(1), HCLS1(1), KRT18(1), LY96(1), NCL(1), PRKCA(2), RHOA(2), ROCK1(5), ROCK2(1), TLR4(2), TLR5(2), TUBA1A(1), TUBA3C(5), TUBA3E(1), TUBA4A(2), TUBA8(1), TUBAL3(1), TUBB1(2), TUBB2B(1), TUBB3(1), TUBB6(1), TUBB8(2), WAS(2), YWHAQ(2), YWHAZ(1) 37496942 65 43 63 19 15 10 5 23 12 0 0.280 1.000 1.000 418 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOC(3), DLAT(1), DLD(2), ENO1(3), ENO2(1), ENO3(1), FBP1(2), FBP2(1), G6PC(1), GAPDH(1), GCK(4), GOT1(2), GOT2(1), HK1(2), HK2(4), HK3(4), LDHB(1), LDHC(1), MDH1(1), PC(2), PDHA1(1), PDHA2(4), PDHX(1), PFKL(2), PFKM(3), PFKP(3), PGAM2(1), PGK2(2), PKLR(1) 31271077 56 28 55 12 21 10 7 8 10 0 0.00893 1.000 1.000 419 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(1), ACACA(7), ACACB(3), ACAT1(2), ACAT2(1), ACSS1(1), ACSS2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH6A1(2), ALDH7A1(2), ECHS1(1), EHHADH(5), HIBCH(1), LDHAL6A(1), LDHB(1), LDHC(1), MUT(3), SUCLA2(1) 29250501 40 29 40 14 10 5 6 14 4 1 0.549 1.000 1.000 420 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(3), ATP4A(1), ATP5A1(2), ATP5C1(1), ATP5F1(1), ATP5G1(1), ATP5G3(1), ATP5J(1), ATP6V0A1(3), ATP6V0A2(4), ATP6V0B(1), ATP6V0D2(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1C2(5), ATP6V1E2(1), ATP6V1F(1), ATP6V1H(1), COX15(2), COX4I2(1), COX7A1(2), COX7C(1), CYC1(1), LHPP(1), NDUFA10(2), NDUFA12(1), NDUFA13(2), NDUFA5(1), NDUFA7(1), NDUFA9(1), NDUFB10(2), NDUFB7(1), NDUFB9(1), NDUFS2(2), NDUFS3(2), NDUFV1(1), SDHA(3), SDHB(2), SDHC(2), TCIRG1(1), UQCRC1(2) 41015058 68 43 68 17 16 14 11 16 11 0 0.0738 1.000 1.000 421 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 60 AKT1(3), AKT2(1), AKT3(1), CDKN2A(1), CREB1(1), EBP(1), ERBB4(4), GAB1(1), GRB2(1), GSK3A(3), GSK3B(1), IGFBP1(1), INPPL1(1), IRS1(3), IRS2(2), IRS4(3), MET(4), MYC(1), PAK1(1), PAK2(2), PAK3(1), PAK6(3), PAK7(3), PARD3(3), PDK1(2), PIK3CD(5), PPP1R13B(3), PREX1(1), PTK2(3), PTPN1(2), RPS6KA1(2), RPS6KA2(2), SHC1(3), SOS1(4), SOS2(1), TSC1(2), TSC2(7), YWHAB(1), YWHAQ(2), YWHAZ(1) 54439393 87 55 86 27 30 12 4 21 20 0 0.233 1.000 1.000 422 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 B4GALT1(2), B4GALT2(2), G6PC(1), G6PC2(1), GAA(1), GALK1(1), GALK2(1), GALT(1), GANC(3), GCK(4), GLB1(2), HK1(2), HK2(4), HK3(4), LCT(6), MGAM(4), PFKL(2), PFKM(3), PFKP(3), PGM3(1), RDH12(1), UGP2(1) 28305603 50 31 50 19 25 4 4 11 6 0 0.359 1.000 1.000 423 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(1), ADH1B(1), ADH4(1), ADH6(3), ADHFE1(1), AKR1A1(2), ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH3B1(1), ALDOC(3), DLAT(1), DLD(2), ENO1(3), ENO2(1), ENO3(1), FBP1(2), FBP2(1), G6PC(1), GAPDH(1), GCK(4), HK1(2), HK2(4), HK3(4), LDHB(1), LDHC(1), PDHA1(1), PDHA2(4), PFKM(3), PFKP(3), PGM3(1), PKLR(1) 35983892 67 37 65 16 23 10 9 14 11 0 0.0267 1.000 1.000 424 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(1), ADH1B(1), ADH4(1), ADH6(3), ADHFE1(1), AKR1A1(2), ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH3B1(1), ALDOC(3), DLAT(1), DLD(2), ENO1(3), ENO2(1), ENO3(1), FBP1(2), FBP2(1), G6PC(1), GAPDH(1), GCK(4), HK1(2), HK2(4), HK3(4), LDHB(1), LDHC(1), PDHA1(1), PDHA2(4), PFKM(3), PFKP(3), PGM3(1), PKLR(1) 35983892 67 37 65 16 23 10 9 14 11 0 0.0267 1.000 1.000 425 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(1), ADH1B(1), ADH4(1), ADH6(3), ADHFE1(1), AGK(2), AGPAT2(1), AGPAT3(2), AGPAT4(2), AGPAT6(2), AKR1A1(2), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH7A1(2), DAK(1), DGAT1(1), DGAT2(1), DGKA(1), DGKB(3), DGKD(4), DGKE(1), DGKH(2), DGKI(6), DGKQ(1), DGKZ(3), GK(1), GLB1(2), GPAM(2), LCT(6), LIPC(1), LIPG(5), LPL(1), MGLL(1), PNLIP(4), PNLIPRP1(1), PPAP2A(1), PPAP2B(1) 43027161 76 51 76 27 22 10 7 21 16 0 0.423 1.000 1.000 426 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(7), ACACB(3), ACAT1(2), ACAT2(1), ACOT12(2), ACSS1(1), ACSS2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH7A1(2), DLAT(1), DLD(2), HAGH(1), LDHAL6A(1), LDHB(1), LDHC(1), LDHD(1), MDH1(1), ME1(3), ME2(1), ME3(1), PC(2), PCK2(2), PDHA1(1), PDHA2(4), PKLR(1) 34419352 49 34 48 13 10 9 8 14 7 1 0.144 1.000 1.000 427 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 50 ACTA1(1), AKT1(3), CALM1(1), CALR(1), CAMK1(3), CAMK1G(2), CAMK4(4), CREBBP(8), F2(2), GATA4(1), GSK3B(1), HRAS(4), MAPK1(1), MEF2C(3), MYH2(7), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), NPPA(1), PIK3R1(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), RAF1(1), SYT1(1) 35864070 65 40 62 25 21 9 8 18 9 0 0.572 1.000 1.000 428 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 45 IMPA1(2), INPP4A(2), INPP4B(3), INPP5A(1), INPP5B(2), INPP5E(2), INPPL1(1), IPMK(1), ITPK1(1), ITPKB(2), OCRL(3), PI4KA(4), PI4KB(2), PIK3C3(1), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIP4K2B(2), PIP5K1B(1), PIP5K1C(2), PLCB1(3), PLCB2(1), PLCB4(8), PLCD1(1), PLCD3(1), PLCD4(1), PLCE1(4), PLCG1(1), PLCG2(3), PLCZ1(3), SYNJ1(3), SYNJ2(3) 52493527 79 59 79 26 25 14 9 21 10 0 0.213 1.000 1.000 429 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 47 AKT1(3), AKT2(1), AKT3(1), BRD4(3), CBL(1), CDKN2A(1), GRB2(1), GSK3A(3), GSK3B(1), IGFBP1(1), INPPL1(1), IRS1(3), IRS2(2), IRS4(3), LNPEP(1), MAPK1(1), PARD3(3), PDK1(2), PIK3CD(5), PIK3R1(2), PTPN1(2), RAF1(1), RPS6KA1(2), RPS6KA2(2), SHC1(3), SORBS1(3), SOS1(4), SOS2(1), YWHAB(1), YWHAQ(2), YWHAZ(1) 41661873 61 44 60 20 19 8 3 14 17 0 0.455 1.000 1.000 430 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ADH1A(1), ADH1B(1), ADH4(1), ADH6(3), ADHFE1(1), ALDH1A3(2), ALDH3A1(1), ALDH3B1(1), AOC2(3), AOC3(1), AOX1(2), CARM1(2), DBH(5), ECH1(1), ESCO1(5), ESCO2(1), FAH(1), GOT1(2), GOT2(1), HEMK1(1), HGD(1), HPD(2), LCMT1(1), LCMT2(1), MAOA(2), MAOB(2), METTL6(1), NAT6(1), PNMT(1), PRMT3(2), PRMT5(2), PRMT7(1), PRMT8(1), SH3GLB1(1), TPO(5), TYR(2), TYRP1(1) 43728130 63 48 63 23 18 9 7 16 13 0 0.548 1.000 1.000 431 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 187 ACTB(1), ACTG1(2), ACTN1(1), ACTN2(2), ACTN4(3), AKT1(3), AKT2(1), AKT3(1), ARHGAP5(4), BCAR1(3), BIRC2(1), CAPN2(2), CAV1(1), CAV3(1), CCND3(1), CHAD(1), COL11A2(4), COL1A1(4), COL1A2(4), COL2A1(1), COL3A1(2), COL4A1(2), COL4A2(4), COL4A4(3), COL4A6(4), COL5A1(9), COL5A2(3), COL5A3(6), COL6A1(2), COL6A2(1), COL6A3(9), COL6A6(3), COMP(2), CRK(1), DIAPH1(2), DOCK1(4), EGF(3), EGFR(3), ERBB2(6), FARP2(3), FIGF(1), FLNA(1), FLNB(6), FLNC(8), FLT1(5), FN1(5), FYN(1), GRB2(1), GSK3B(1), HGF(3), HRAS(4), IGF1R(4), ILK(1), ITGA1(2), ITGA10(5), ITGA11(3), ITGA2(5), ITGA2B(5), ITGA3(2), ITGA4(3), ITGA6(2), ITGA7(4), ITGA8(3), ITGA9(4), ITGAV(3), ITGB4(4), ITGB5(1), ITGB6(6), ITGB7(1), ITGB8(2), KDR(7), LAMA1(6), LAMA2(6), LAMA3(8), LAMA4(6), LAMA5(7), LAMB1(9), LAMB2(8), LAMB3(1), LAMB4(4), LAMC1(4), LAMC2(1), LAMC3(3), MAPK1(1), MET(4), MYL5(1), MYLK(4), MYLK2(4), PAK1(1), PAK2(2), PAK3(1), PAK6(3), PAK7(3), PARVB(1), PARVG(3), PDGFA(2), PDGFB(1), PDGFC(1), PDGFD(3), PDGFRA(3), PDGFRB(1), PDPK1(1), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIK3R1(2), PIK3R2(3), PIK3R3(2), PIK3R5(2), PIP5K1C(2), PPP1CA(1), PPP1R12A(1), PRKCA(2), PRKCG(1), PTK2(3), PXN(1), RAC1(1), RAC2(1), RAC3(2), RAF1(1), RAP1A(1), RAPGEF1(4), RELN(10), RHOA(2), ROCK1(5), ROCK2(1), SHC1(3), SHC2(1), SHC3(1), SHC4(1), SOS1(4), SOS2(1), THBS1(3), THBS2(1), THBS3(3), THBS4(4), TLN1(4), TLN2(5), TNC(4), TNN(5), TNR(2), TNXB(12), VAV1(3), VAV2(3), VAV3(4), VCL(1), VEGFA(2), VTN(1), VWF(6) 265026246 456 223 449 166 153 88 35 109 69 2 0.126 1.000 1.000 432 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 236 ADCYAP1R1(2), ADORA1(3), ADORA2A(2), ADORA3(3), ADRA1A(1), ADRA1B(2), ADRA2A(2), ADRA2B(2), ADRA2C(2), ADRB1(1), AGTR1(3), AVPR1A(3), AVPR1B(2), BDKRB1(3), BDKRB2(2), BRS3(1), C3AR1(2), CALCR(4), CALCRL(1), CCKAR(2), CCKBR(2), CGA(1), CHRM2(2), CHRM3(1), CHRM4(3), CNR1(5), CNR2(1), CRHR2(2), CTSG(2), CYSLTR1(2), CYSLTR2(1), DRD2(1), DRD3(2), DRD4(1), DRD5(1), EDNRA(1), F2(2), F2R(2), F2RL1(1), FPR1(3), FSHR(2), GABBR1(1), GABBR2(3), GABRA3(1), GABRA4(2), GABRA5(2), GABRA6(2), GABRB1(6), GABRB2(3), GABRB3(1), GABRD(2), GABRE(4), GABRG1(5), GABRG2(1), GABRP(2), GABRQ(1), GABRR1(2), GABRR2(3), GH1(3), GH2(1), GHR(1), GHRHR(1), GHSR(1), GIPR(2), GLP1R(1), GLP2R(1), GLRA1(2), GLRA2(3), GNRHR(4), GPR156(2), GPR35(1), GPR50(4), GPR63(2), GPR83(2), GRIA1(12), GRIA2(5), GRIA3(1), GRIA4(4), GRID1(4), GRID2(6), GRIK1(5), GRIK2(1), GRIK3(6), GRIK4(3), GRIK5(1), GRIN1(3), GRIN2A(11), GRIN2B(8), GRIN2C(3), GRIN3A(3), GRIN3B(1), GRM1(9), GRM2(2), GRM3(4), GRM4(2), GRM5(5), GRM6(3), GRM7(2), GRM8(2), GRPR(1), GZMA(1), HCRTR2(5), HRH1(1), HRH2(1), HRH4(2), HTR1A(3), HTR1D(2), HTR1E(6), HTR2A(2), HTR2B(2), HTR2C(3), HTR4(1), HTR5A(1), HTR6(2), LEPR(2), LHCGR(1), MAS1(1), MC3R(2), MC4R(1), MC5R(1), MCHR1(1), MCHR2(1), MLNR(1), MTNR1A(1), MTNR1B(2), NMBR(1), NMUR1(1), NMUR2(2), NPY1R(2), NPY2R(2), NPY5R(2), NTSR1(3), NTSR2(3), OPRD1(1), OPRK1(1), OPRL1(2), OPRM1(2), P2RX1(2), P2RX4(1), P2RX5(2), P2RY1(1), P2RY10(1), P2RY11(2), P2RY14(2), P2RY2(2), P2RY4(2), P2RY6(1), P2RY8(1), PARD3(3), PRL(1), PRLR(1), PRSS1(2), PTGER2(2), PTGER4(1), PTGIR(3), PTH2R(1), RXFP1(2), RXFP2(1), SCTR(3), SSTR1(5), SSTR2(1), SSTR3(2), SSTR4(3), SSTR5(2), TAAR2(1), TAAR5(1), TAAR6(3), TAAR8(3), TACR1(2), TACR2(1), TACR3(2), TBXA2R(5), THRA(6), TRHR(1), TRPV1(1), TSHR(1) 163340010 405 218 398 129 189 56 27 93 40 0 0.000726 1.000 1.000 433 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(3), ADCY8(7), ADCY9(5), ADORA2A(2), ADRA1A(1), ADRA1B(2), ADRA1D(2), ADRB1(1), AGTR1(3), ATP2A1(5), ATP2A2(1), ATP2A3(1), ATP2B1(2), ATP2B2(7), ATP2B3(7), ATP2B4(5), AVPR1A(3), AVPR1B(2), BDKRB1(3), BDKRB2(2), CACNA1A(12), CACNA1B(3), CACNA1C(4), CACNA1D(4), CACNA1E(18), CACNA1F(2), CACNA1G(4), CACNA1H(3), CACNA1I(2), CACNA1S(4), CALM1(1), CALML3(1), CALML6(1), CAMK2A(1), CAMK2D(2), CAMK4(4), CCKAR(2), CCKBR(2), CD38(1), CHRM2(2), CHRM3(1), CYSLTR1(2), CYSLTR2(1), EDNRA(1), EGFR(3), ERBB2(6), ERBB3(5), ERBB4(4), F2R(2), GNA11(1), GNA14(1), GNAL(3), GNAS(2), GRIN1(3), GRIN2A(11), GRIN2C(3), GRM1(9), GRM5(5), GRPR(1), HRH1(1), HRH2(1), HTR2A(2), HTR2B(2), HTR2C(3), HTR4(1), HTR5A(1), HTR6(2), ITPKB(2), ITPR1(4), ITPR2(8), ITPR3(6), LHCGR(1), MYLK(4), MYLK2(4), NOS1(3), NOS3(2), NTSR1(3), P2RX1(2), P2RX4(1), P2RX5(2), PDE1B(1), PDE1C(3), PDGFRA(3), PDGFRB(1), PHKA1(2), PHKA2(2), PHKB(3), PHKG2(2), PLCB1(3), PLCB2(1), PLCB4(8), PLCD1(1), PLCD3(1), PLCD4(1), PLCE1(4), PLCG1(1), PLCG2(3), PLCZ1(3), PLN(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKACA(2), PRKCA(2), PRKCG(1), PRKX(2), RYR1(20), RYR2(17), RYR3(18), SLC25A6(1), SLC8A1(7), SLC8A2(1), SLC8A3(4), SPHK1(1), SPHK2(1), TACR1(2), TACR2(1), TACR3(2), TBXA2R(5), TRHR(1), VDAC1(1) 196886616 402 212 400 160 167 57 24 95 59 0 0.365 1.000 1.000 434 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 201 ABI2(1), ACTN1(1), ACTN2(2), ACTN4(3), APC(10), APC2(3), ARAF(1), ARHGEF1(5), ARHGEF12(1), ARHGEF4(1), ARHGEF6(1), ARHGEF7(1), ARPC5(1), ARPC5L(1), BAIAP2(1), BCAR1(3), BDKRB1(3), BDKRB2(2), CD14(2), CFL1(1), CHRM2(2), CHRM3(1), CHRM4(3), CRK(1), CYFIP1(4), CYFIP2(6), DIAPH1(2), DIAPH3(2), DOCK1(4), EGF(3), EGFR(3), F2(2), F2R(2), FGD1(2), FGD3(2), FGF10(2), FGF11(1), FGF16(2), FGF20(1), FGF21(1), FGF23(2), FGF4(1), FGF5(3), FGF7(1), FGF9(3), FGFR1(2), FGFR2(3), FGFR3(2), FN1(5), GIT1(1), GNA13(2), GSN(6), HRAS(4), IQGAP1(3), IQGAP2(2), IQGAP3(2), ITGA1(2), ITGA10(5), ITGA11(3), ITGA2(5), ITGA2B(5), ITGA3(2), ITGA4(3), ITGA6(2), ITGA7(4), ITGA8(3), ITGA9(4), ITGAD(5), ITGAE(1), ITGAL(5), ITGAM(3), ITGAV(3), ITGAX(3), ITGB2(2), ITGB4(4), ITGB5(1), ITGB6(6), ITGB7(1), ITGB8(2), KRAS(2), LIMK1(2), LIMK2(4), MAPK1(1), MOS(1), MRAS(2), MSN(1), MYH10(7), MYH14(3), MYH9(6), MYL5(1), MYLK(4), MYLK2(4), NCKAP1(1), NCKAP1L(6), PAK1(1), PAK2(2), PAK3(1), PAK6(3), PAK7(3), PDGFA(2), PDGFB(1), PDGFRA(3), PDGFRB(1), PFN1(1), PFN2(3), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIK3R1(2), PIK3R2(3), PIK3R3(2), PIK3R5(2), PIP4K2B(2), PIP5K1B(1), PIP5K1C(2), PPP1CA(1), PPP1R12A(1), PPP1R12B(1), PTK2(3), PXN(1), RAC1(1), RAC2(1), RAC3(2), RAF1(1), RDX(1), RHOA(2), ROCK1(5), ROCK2(1), RRAS2(2), SCIN(1), SLC9A1(2), SOS1(4), SOS2(1), SSH1(3), SSH2(8), SSH3(3), TIAM1(5), TIAM2(6), VAV1(3), VAV2(3), VAV3(4), VCL(1), WAS(2), WASF1(2), WASF2(2) 199827943 374 204 367 118 120 57 36 99 61 1 0.0388 1.000 1.000 435 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 245 ACVR1B(2), ACVR1C(1), AKT1(3), AKT2(1), AKT3(1), ARRB1(1), ATF2(3), ATF4(1), BDNF(2), CACNA1A(12), CACNA1B(3), CACNA1C(4), CACNA1D(4), CACNA1E(18), CACNA1F(2), CACNA1G(4), CACNA1H(3), CACNA1I(2), CACNA1S(4), CACNA2D1(2), CACNA2D2(3), CACNA2D3(1), CACNA2D4(2), CACNB1(3), CACNB2(3), CACNB4(1), CACNG1(1), CACNG3(1), CACNG4(1), CACNG5(1), CACNG7(4), CACNG8(1), CD14(2), CDC25B(5), CRK(1), DAXX(2), DUSP1(1), DUSP14(1), DUSP16(1), DUSP7(1), DUSP8(3), ECSIT(2), EGF(3), EGFR(3), FAS(1), FASLG(1), FGF10(2), FGF11(1), FGF16(2), FGF20(1), FGF21(1), FGF23(2), FGF4(1), FGF5(3), FGF7(1), FGF9(3), FGFR1(2), FGFR2(3), FGFR3(2), FLNA(1), FLNB(6), FLNC(8), GRB2(1), HRAS(4), IKBKB(1), IL1A(1), IL1R2(1), JUND(2), KRAS(2), MAP2K3(1), MAP2K4(4), MAP2K6(1), MAP2K7(4), MAP3K1(5), MAP3K10(4), MAP3K12(3), MAP3K13(3), MAP3K3(1), MAP3K4(3), MAP3K5(2), MAP3K7(2), MAP3K8(1), MAP4K1(2), MAP4K2(1), MAP4K4(1), MAPK1(1), MAPK12(1), MAPK13(1), MAPK8IP3(4), MAPKAPK3(1), MAPKAPK5(1), MEF2C(3), MOS(1), MRAS(2), MYC(1), NF1(4), NFATC2(2), NFATC4(1), NFKB1(3), NLK(1), NR4A1(1), NTF3(2), NTRK1(9), PAK1(1), PAK2(2), PDGFA(2), PDGFB(1), PDGFRA(3), PDGFRB(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PPM1A(3), PPM1B(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), PPP5C(2), PRKACA(2), PRKCA(2), PRKCG(1), PRKX(2), PTPN5(3), PTPN7(4), PTPRR(1), RAC1(1), RAC2(1), RAC3(2), RAF1(1), RAP1A(1), RAPGEF2(2), RASA1(1), RASGRF1(3), RASGRF2(3), RASGRP2(1), RASGRP4(1), RPS6KA1(2), RPS6KA2(2), RPS6KA4(3), RPS6KA5(3), RPS6KA6(1), RRAS2(2), SOS1(4), SOS2(1), STK3(1), STK4(3), TAOK1(3), TAOK2(3), TAOK3(2), TGFB2(2), TGFBR1(2), TNF(1), TNFRSF1A(1), TRAF2(5), TRAF6(2) 207304878 355 182 352 144 127 57 33 75 62 1 0.655 1.000 1.000 436 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 135 ACTB(1), ACTG1(2), CHAD(1), COL11A2(4), COL17A1(4), COL1A1(4), COL1A2(4), COL2A1(1), COL3A1(2), COL4A1(2), COL4A2(4), COL4A4(3), COL4A6(4), COL5A1(9), COL5A2(3), COL5A3(6), COL6A1(2), COL6A2(1), COL6A3(9), COL6A6(3), COMP(2), DSC1(2), DSC3(2), DSG1(1), DSG2(4), DSG4(2), FN1(5), GJA1(1), GJA3(1), GJA4(2), GJA5(3), GJA8(5), GJB2(1), GJB4(2), GJB5(2), GJB6(1), GJC2(2), ITGA6(2), ITGB4(4), KRT1(1), KRT10(1), KRT12(1), KRT13(2), KRT14(1), KRT15(2), KRT16(4), KRT18(1), KRT19(1), KRT2(1), KRT23(2), KRT24(2), KRT25(6), KRT27(4), KRT28(1), KRT3(2), KRT31(4), KRT33A(1), KRT33B(1), KRT36(2), KRT37(2), KRT38(2), KRT39(2), KRT4(3), KRT40(2), KRT5(1), KRT6A(1), KRT6B(2), KRT6C(4), KRT7(3), KRT72(1), KRT73(2), KRT75(2), KRT76(2), KRT77(1), KRT78(5), KRT79(2), KRT81(1), KRT83(1), KRT84(1), KRT85(3), KRT86(1), KRT9(2), LAMA1(6), LAMA2(6), LAMA3(8), LAMA4(6), LAMA5(7), LAMB1(9), LAMB2(8), LAMB3(1), LAMB4(4), LAMC1(4), LAMC2(1), LAMC3(3), LMNA(4), LMNB2(2), NES(3), RELN(10), THBS1(3), THBS2(1), THBS3(3), THBS4(4), TNC(4), TNN(5), TNR(2), TNXB(12), VIM(1), VTN(1), VWF(6) 179659989 323 162 322 100 141 62 12 61 46 1 0.00296 1.000 1.000 437 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(3), ADCY5(2), ADCY6(2), ADCY8(7), ADCY9(5), ADRA1A(1), ADRA1B(2), ADRA1D(2), ADRB1(1), ANXA6(2), ARRB1(1), ATP1A4(1), ATP1B2(2), ATP2A2(1), ATP2A3(1), ATP2B1(2), ATP2B2(7), ATP2B3(7), CACNA1A(12), CACNA1B(3), CACNA1C(4), CACNA1D(4), CACNA1E(18), CACNA1S(4), CACNB1(3), CALM1(1), CALR(1), CAMK1(3), CAMK2A(1), CAMK2D(2), CAMK4(4), CHRM2(2), CHRM3(1), CHRM4(3), GJA1(1), GJA4(2), GJA5(3), GJB2(1), GJB4(2), GJB5(2), GJB6(1), GNA11(1), GNAI2(2), GNAO1(1), GNAZ(3), GNB1(1), GNB2(1), GNB3(2), GNB4(1), GNB5(1), GNG2(1), GNGT1(1), GRK4(1), GRK6(2), ITPR1(4), ITPR2(8), ITPR3(6), KCNB1(4), KCNJ5(2), MIB1(2), NME7(1), PLN(1), PRKACA(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), PRKCA(2), PRKCE(2), PRKCG(1), PRKCH(1), PRKCQ(3), PRKCZ(3), PRKD1(2), RGS11(1), RGS16(2), RGS18(1), RGS3(2), RGS6(3), RGS7(1), RGS9(2), RYR1(20), RYR2(17), RYR3(18), SLC8A1(7), SLC8A3(4), USP5(1), YWHAB(1), YWHAQ(2) 137346408 286 157 285 117 133 34 17 63 39 0 0.489 1.000 1.000 438 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 84 AGRN(3), CD36(1), CD47(1), CHAD(1), COL11A2(4), COL1A1(4), COL1A2(4), COL2A1(1), COL3A1(2), COL4A1(2), COL4A2(4), COL4A4(3), COL4A6(4), COL5A1(9), COL5A2(3), COL5A3(6), COL6A1(2), COL6A2(1), COL6A3(9), COL6A6(3), DAG1(2), FN1(5), FNDC1(6), FNDC3A(2), GP5(4), GP9(1), HMMR(1), HSPG2(12), ITGA1(2), ITGA10(5), ITGA11(3), ITGA2(5), ITGA2B(5), ITGA3(2), ITGA4(3), ITGA6(2), ITGA7(4), ITGA8(3), ITGA9(4), ITGAV(3), ITGB4(4), ITGB5(1), ITGB6(6), ITGB7(1), ITGB8(2), LAMA1(6), LAMA2(6), LAMA3(8), LAMA4(6), LAMA5(7), LAMB1(9), LAMB2(8), LAMB3(1), LAMB4(4), LAMC1(4), LAMC2(1), LAMC3(3), RELN(10), SDC3(1), SDC4(1), SV2A(3), SV2B(2), THBS1(3), THBS2(1), THBS3(3), THBS4(4), TNC(4), TNN(5), TNR(2), TNXB(12), VTN(1), VWF(6) 161179154 276 148 274 87 103 53 14 60 45 1 0.0185 1.000 1.000 439 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 128 ACTB(1), ACTG1(2), ACTN1(1), ACTN2(2), ACTN4(3), AKT1(3), AKT2(1), AKT3(1), ASH1L(7), CGN(4), CLDN1(1), CLDN10(1), CLDN15(1), CLDN16(1), CLDN20(1), CLDN23(2), CLDN9(2), CSNK2A2(1), CSNK2B(1), CTNNA1(2), CTNNA2(5), CTNNA3(2), CTTN(1), EPB41L1(2), EPB41L2(4), EXOC3(4), EXOC4(2), GNAI1(2), GNAI2(2), HCLS1(1), HRAS(4), IGSF5(1), INADL(5), JAM2(1), KRAS(2), LLGL1(3), LLGL2(2), MAGI1(2), MAGI2(2), MAGI3(3), MLLT4(5), MPDZ(3), MRAS(2), MYH1(4), MYH10(7), MYH11(7), MYH13(8), MYH14(3), MYH15(7), MYH2(7), MYH3(3), MYH4(9), MYH6(10), MYH7(7), MYH7B(4), MYH8(11), MYH9(6), MYL5(1), PARD3(3), PPM1J(1), PPP2CA(2), PPP2CB(1), PPP2R1B(2), PPP2R2A(1), PPP2R2B(4), PPP2R2C(1), PPP2R3A(1), PPP2R4(1), PRKCA(2), PRKCE(2), PRKCG(1), PRKCH(1), PRKCI(1), PRKCQ(3), PRKCZ(3), RHOA(2), RRAS2(2), SPTAN1(2), SYMPK(2), TJAP1(2), TJP1(1), TJP2(5), TJP3(2), VAPA(2), YES1(1) 139524770 243 140 239 86 94 37 19 57 36 0 0.239 1.000 1.000 440 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 126 ABL1(5), ABLIM1(3), ARHGEF12(1), CFL1(1), DCC(6), DPYSL5(1), EFNA2(1), EFNA3(1), EFNA5(2), EFNB2(1), EFNB3(2), EPHA1(5), EPHA2(2), EPHA3(5), EPHA4(4), EPHA5(1), EPHA6(2), EPHA7(2), EPHA8(2), EPHB1(8), EPHB2(4), EPHB3(4), EPHB6(3), FES(3), FYN(1), GNAI1(2), GNAI2(2), GSK3B(1), HRAS(4), KRAS(2), L1CAM(6), LIMK1(2), LIMK2(4), LRRC4C(3), MAPK1(1), MET(4), NFAT5(1), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), NGEF(5), NRP1(2), NTN1(1), NTNG1(3), PAK1(1), PAK2(2), PAK3(1), PAK6(3), PAK7(3), PLXNA1(8), PLXNA2(3), PLXNA3(2), PLXNB1(4), PLXNB2(4), PLXNB3(1), PLXNC1(3), PPP3CA(2), PPP3CB(1), PPP3CC(2), PTK2(3), RAC1(1), RAC2(1), RAC3(2), RASA1(1), RGS3(2), RHOA(2), RHOD(2), ROBO1(7), ROBO2(10), ROBO3(2), ROCK1(5), ROCK2(1), SEMA3A(2), SEMA3C(3), SEMA3D(4), SEMA3E(2), SEMA3F(4), SEMA3G(2), SEMA4A(1), SEMA4C(3), SEMA4F(2), SEMA4G(2), SEMA5A(5), SEMA5B(2), SEMA6A(5), SEMA6C(3), SEMA6D(2), SEMA7A(2), SLIT1(2), SLIT2(3), SLIT3(4), SRGAP1(4), SRGAP3(2), UNC5A(1), UNC5B(5), UNC5D(3) 143530427 266 137 262 97 108 34 23 69 32 0 0.307 1.000 1.000 441 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 249 ACVR1B(2), ACVR2A(2), BMP2(2), BMP7(3), BMPR1A(2), BMPR1B(2), BMPR2(3), CCL11(1), CCL15(1), CCL17(1), CCL21(1), CCL28(1), CCL7(1), CCL8(1), CCR1(3), CCR2(3), CCR3(1), CCR4(1), CCR5(2), CCR6(1), CCR7(3), CCR9(1), CD27(1), CD40(1), CD40LG(1), CNTF(1), CSF1(1), CSF1R(5), CSF2RA(3), CSF2RB(1), CSF3R(1), CX3CL1(1), CXCL9(1), CXCR6(1), EDA(1), EGF(3), EGFR(3), EPOR(1), FAS(1), FASLG(1), FLT1(5), FLT3(2), FLT3LG(1), FLT4(4), GH1(3), GH2(1), GHR(1), HGF(3), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(2), IFNB1(1), IFNGR2(1), IFNW1(1), IL10(1), IL10RA(2), IL11RA(1), IL12A(1), IL12B(1), IL12RB2(1), IL13RA1(1), IL17A(1), IL17RA(4), IL17RB(1), IL18RAP(2), IL1A(1), IL1R2(1), IL1RAP(2), IL20(1), IL20RA(2), IL21(2), IL21R(2), IL22(1), IL22RA2(1), IL23R(1), IL24(3), IL25(1), IL26(1), IL2RB(1), IL3RA(3), IL4(1), IL4R(3), IL6(1), IL6ST(7), IL7(2), IL7R(1), IL9(2), INHBA(2), INHBC(2), INHBE(1), KDR(7), KIT(3), LEPR(2), LIFR(4), LTBR(2), MET(4), OSMR(1), PDGFB(1), PDGFC(1), PDGFRA(3), PDGFRB(1), PF4(1), PRL(1), PRLR(1), TGFB2(2), TGFBR1(2), TNF(1), TNFRSF10A(1), TNFRSF10B(2), TNFRSF10C(1), TNFRSF10D(1), TNFRSF11B(2), TNFRSF13B(3), TNFRSF18(2), TNFRSF1A(1), TNFRSF1B(1), TNFRSF21(7), TNFRSF4(1), TNFRSF6B(1), TNFRSF8(3), TNFSF11(1), TNFSF12(1), TNFSF14(2), TNFSF15(1), TNFSF8(2), TPO(5), VEGFA(2), XCL1(1), XCR1(2) 130081861 236 132 236 84 61 38 26 67 43 1 0.264 1.000 1.000 442 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 142 APC(10), APC2(3), AXIN1(1), AXIN2(5), BTRC(3), CACYBP(1), CAMK2A(1), CAMK2D(2), CCND3(1), CHD8(3), CREBBP(8), CSNK1A1L(1), CSNK1E(3), CSNK2A2(1), CSNK2B(1), CUL1(2), DAAM1(4), DAAM2(4), DKK1(3), DKK2(2), DVL1(1), DVL2(3), DVL3(1), EP300(7), FBXW11(2), FZD1(2), FZD10(2), FZD2(4), FZD4(2), FZD5(4), FZD6(3), FZD7(3), FZD9(2), GSK3B(1), LEF1(2), LRP5(4), LRP6(4), MAP3K7(2), MYC(1), NFAT5(1), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), NKD2(1), NLK(1), PLCB1(3), PLCB2(1), PLCB4(8), PPARD(4), PPP2CA(2), PPP2CB(1), PPP2R1B(2), PPP2R2A(1), PPP2R2B(4), PPP2R2C(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRICKLE1(2), PRICKLE2(7), PRKACA(2), PRKCA(2), PRKCG(1), PRKX(2), RAC1(1), RAC2(1), RAC3(2), RHOA(2), ROCK1(5), ROCK2(1), RUVBL1(1), SFRP2(3), SFRP5(1), SMAD2(2), SMAD3(1), SMAD4(7), SOX17(1), TBL1X(1), TBL1XR1(2), TCF7(1), TCF7L1(1), TCF7L2(2), VANGL2(5), WIF1(2), WNT1(1), WNT2(2), WNT2B(1), WNT3A(1), WNT4(1), WNT5A(1), WNT5B(1), WNT6(3), WNT7A(2), WNT9A(2) 117346679 223 127 220 82 69 41 24 46 43 0 0.325 1.000 1.000 443 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADORA1(3), ADORA2A(2), ADORA3(3), ADRA1A(1), ADRA1B(2), ADRA1D(2), ADRA2A(2), ADRA2C(2), ADRB1(1), AGTR1(3), AVPR1A(3), AVPR1B(2), BDKRB1(3), BDKRB2(2), BRS3(1), C3AR1(2), CCKAR(2), CCKBR(2), CCR1(3), CCR2(3), CCR3(1), CCR4(1), CCR5(2), CCR6(1), CCR7(3), CCR9(1), CCRL2(1), CHRM2(2), CHRM3(1), CHRM4(3), CMKLR1(2), CNR1(5), CNR2(1), DRD2(1), DRD3(2), DRD4(1), DRD5(1), EDNRA(1), F2R(2), F2RL1(1), FPR1(3), FSHR(2), GALT(1), GHSR(1), GPR17(2), GPR174(1), GPR35(1), GPR37(2), GPR37L1(3), GPR4(1), GPR50(4), GPR6(1), GPR63(2), GPR83(2), GPR87(3), GRPR(1), HCRTR2(5), HRH1(1), HRH2(1), HTR1A(3), HTR1D(2), HTR1E(6), HTR2A(2), HTR2B(2), HTR2C(3), HTR4(1), HTR5A(1), HTR6(2), LHCGR(1), MAS1(1), MC3R(2), MC4R(1), MC5R(1), MLNR(1), MTNR1A(1), MTNR1B(2), NMBR(1), NMUR1(1), NMUR2(2), NPY1R(2), NPY2R(2), NPY5R(2), NTSR1(3), NTSR2(3), OPN1SW(1), OPN3(3), OPRD1(1), OPRK1(1), OPRL1(2), OPRM1(2), OR12D3(1), OR1Q1(1), OR5V1(1), OR7A5(2), OR8B8(1), P2RY1(1), P2RY10(1), P2RY11(2), P2RY14(2), P2RY2(2), P2RY6(1), PTGER2(2), PTGER4(1), PTGIR(3), RGR(2), RHO(1), RRH(1), SSTR1(5), SSTR2(1), SSTR3(2), SSTR4(3), TBXA2R(5), TRHR(1) 89410440 214 126 212 77 91 36 13 55 19 0 0.0422 1.000 1.000 444 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 129 ACACA(7), ACACB(3), AKT1(3), AKT2(1), AKT3(1), ARAF(1), CALM1(1), CALML3(1), CALML6(1), CBL(1), CBLB(1), CBLC(1), CRK(1), EXOC7(1), FASN(5), FBP1(2), FBP2(1), FOXO1(1), G6PC(1), G6PC2(1), GCK(4), GRB2(1), GSK3B(1), GYS1(4), HRAS(4), IKBKB(1), INPP5D(3), IRS1(3), IRS2(2), IRS4(3), KRAS(2), MAPK1(1), PCK2(2), PDE3A(2), PDE3B(3), PDPK1(1), PFKL(2), PFKM(3), PFKP(3), PHKA1(2), PHKA2(2), PHKB(3), PHKG2(2), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIK3R1(2), PIK3R2(3), PIK3R3(2), PIK3R5(2), PKLR(1), PPARGC1A(4), PPP1CA(1), PPP1R3A(7), PPP1R3B(2), PRKAA2(5), PRKACA(2), PRKAG1(3), PRKAG3(1), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), PRKCI(1), PRKCZ(3), PRKX(2), PTPN1(2), PTPRF(5), PYGB(4), PYGL(4), PYGM(1), RAF1(1), RAPGEF1(4), RPS6(1), RPS6KB2(2), SHC1(3), SHC2(1), SHC3(1), SHC4(1), SOCS4(2), SORBS1(3), SOS1(4), SOS2(1), SREBF1(2), TRIP10(1), TSC1(2), TSC2(7) 114672197 204 124 199 66 76 31 28 43 25 1 0.0549 1.000 1.000 445 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 130 ALCAM(2), CADM1(2), CADM3(3), CD2(1), CD226(2), CD276(1), CD28(2), CD34(1), CD4(1), CD40(1), CD40LG(1), CD6(1), CD86(1), CD8A(1), CD8B(2), CDH1(4), CDH15(1), CDH2(2), CDH3(3), CDH4(5), CDH5(5), CLDN1(1), CLDN10(1), CLDN15(1), CLDN16(1), CLDN20(1), CLDN23(2), CLDN9(2), CNTN2(1), CNTNAP1(9), CNTNAP2(2), ESAM(1), GLG1(2), HLA-A(1), HLA-DMA(1), HLA-DMB(1), HLA-DOA(1), HLA-DQA2(1), HLA-DRA(1), HLA-DRB5(1), HLA-F(1), HLA-G(2), ICAM1(1), ICAM2(2), ICAM3(1), ITGA4(3), ITGA6(2), ITGA8(3), ITGA9(4), ITGAL(5), ITGAM(3), ITGAV(3), ITGB2(2), ITGB7(1), ITGB8(2), JAM2(1), L1CAM(6), MADCAM1(1), MAG(2), NCAM1(1), NCAM2(3), NEGR1(3), NEO1(4), NFASC(3), NLGN1(1), NLGN2(1), NLGN3(2), NRCAM(4), NRXN1(3), NRXN2(2), NRXN3(8), PDCD1(1), PTPRC(8), PTPRF(5), PTPRM(1), PVRL1(2), PVRL2(2), PVRL3(1), SDC3(1), SDC4(1), SELE(1), SELP(4), SELPLG(2), SIGLEC1(8), SPN(1), VCAM1(2), VCAN(4) 108188392 197 122 193 70 72 35 17 42 31 0 0.181 1.000 1.000 446 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 73 ARAF(1), CACNA1A(12), GNA11(1), GNA13(2), GNAI1(2), GNAI2(2), GNAO1(1), GNAS(2), GNAZ(3), GRIA1(12), GRIA2(5), GRIA3(1), GRID2(6), GRM1(9), GRM5(5), GUCY1A2(4), GUCY1A3(1), GUCY2C(6), GUCY2D(1), GUCY2F(3), HRAS(4), IGF1R(4), ITPR1(4), ITPR2(8), ITPR3(6), KRAS(2), LYN(2), MAPK1(1), NOS1(3), NOS3(2), NPR1(1), NPR2(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCB1(3), PLCB2(1), PLCB4(8), PPP2CA(2), PPP2CB(1), PPP2R1B(2), PPP2R2A(1), PPP2R2B(4), PPP2R2C(1), PRKCA(2), PRKCG(1), PRKG1(1), RAF1(1), RYR1(20) 79709946 174 122 169 50 71 23 12 47 21 0 0.0486 1.000 1.000 447 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(1), ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(3), ADCY5(2), ADCY6(2), ADCY8(7), ADCY9(5), ARRB1(1), ATF2(3), ATF3(1), ATF4(1), ATF5(1), ATP2A2(1), ATP2A3(1), CALCA(1), CALM1(1), CAMK2A(1), CAMK2D(2), CNN1(1), CORIN(4), DGKZ(3), GBA2(1), GJA1(1), GNB1(1), GNB2(1), GNB3(2), GNB4(1), GNB5(1), GNG2(1), GNGT1(1), GRK4(1), GRK6(2), GSTO1(2), GUCY1A3(1), IGFBP1(1), IGFBP3(1), IGFBP4(1), IGFBP6(1), IL6(1), ITPR1(4), ITPR2(8), ITPR3(6), MAFF(1), MIB1(2), MYLK2(4), NFKB1(3), NOS1(3), NOS3(2), PLCD1(1), PLCG1(1), PLCG2(3), PRKACA(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), PRKCA(2), PRKCE(2), PRKCH(1), PRKCQ(3), PRKCZ(3), PRKD1(2), RAMP1(1), RAMP2(1), RAMP3(1), RGS11(1), RGS16(2), RGS18(1), RGS3(2), RGS6(3), RGS7(1), RGS9(2), RYR1(20), RYR2(17), RYR3(18), SLC8A1(7), SP1(2), TNXB(12), USP5(1), YWHAB(1), YWHAQ(2) 126857847 226 121 226 105 90 36 14 50 36 0 0.872 1.000 1.000 448 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 149 AKT1(3), AKT2(1), AKT3(1), CBL(1), CBLB(1), CBLC(1), CCND3(1), CNTF(1), CREBBP(8), CSF2RA(3), CSF2RB(1), CSF3R(1), EP300(7), EPOR(1), GH1(3), GH2(1), GHR(1), GRB2(1), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(2), IFNB1(1), IFNGR2(1), IFNW1(1), IL10(1), IL10RA(2), IL11RA(1), IL12A(1), IL12B(1), IL12RB2(1), IL13RA1(1), IL20(1), IL20RA(2), IL21(2), IL21R(2), IL22(1), IL22RA2(1), IL23R(1), IL24(3), IL26(1), IL2RB(1), IL3RA(3), IL4(1), IL4R(3), IL6(1), IL6ST(7), IL7(2), IL7R(1), IL9(2), JAK1(6), JAK2(1), JAK3(1), LEPR(2), LIFR(4), MYC(1), OSMR(1), PIAS3(2), PIAS4(3), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIK3R1(2), PIK3R2(3), PIK3R3(2), PIK3R5(2), PRL(1), PRLR(1), PTPN11(1), SOCS4(2), SOCS5(2), SOS1(4), SOS2(1), SPRED2(2), SPRY3(1), STAM2(1), STAT1(1), STAT2(2), STAT3(6), STAT4(6), STAT5B(2), STAT6(3), TPO(5), TYK2(2) 105430214 177 111 176 62 41 29 24 44 39 0 0.351 1.000 1.000 449 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 141 ADA(1), ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(3), ADCY5(2), ADCY6(2), ADCY8(7), ADCY9(5), ADSL(1), ADSS(1), AK2(1), AK5(1), AK7(2), ALLC(1), AMPD1(4), AMPD2(4), AMPD3(1), APRT(1), ATIC(5), DGUOK(1), ENPP1(3), ENPP3(2), ENTPD1(1), ENTPD3(2), ENTPD4(2), ENTPD6(2), FHIT(1), GART(1), GMPR(3), GMPR2(1), GUCY1A2(4), GUCY1A3(1), GUCY2C(6), GUCY2D(1), GUCY2F(3), NME1(1), NME7(1), NPR1(1), NPR2(1), NT5C1B(2), NT5C2(3), NT5E(1), NT5M(1), PAPSS2(1), PDE10A(5), PDE1C(3), PDE2A(2), PDE3B(3), PDE4A(3), PDE4C(1), PDE5A(1), PDE6D(1), PDE7A(1), PDE8A(5), PDE8B(1), PDE9A(4), PFAS(2), PKLR(1), POLA1(1), POLA2(1), POLD1(3), POLD2(1), POLD3(1), POLE(6), POLE2(1), POLR1A(3), POLR1B(3), POLR1C(2), POLR2A(6), POLR2B(4), POLR2C(1), POLR2E(1), POLR3A(4), POLR3B(3), PPAT(1), PRIM2(2), PRPS1L1(4), RFC5(1), RRM2(1), XDH(1) 119593105 180 105 180 70 64 41 15 38 22 0 0.438 1.000 1.000 450 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(3), ADCY5(2), ADCY6(2), ADCY8(7), ADCY9(5), ADRB1(1), DRD2(1), EGF(3), EGFR(3), GJA1(1), GNA11(1), GNAI1(2), GNAI2(2), GNAS(2), GRB2(1), GRM1(9), GRM5(5), GUCY1A2(4), GUCY1A3(1), GUCY2C(6), GUCY2D(1), GUCY2F(3), HRAS(4), HTR2A(2), HTR2B(2), HTR2C(3), ITPR1(4), ITPR2(8), ITPR3(6), KRAS(2), MAPK1(1), NPR1(1), NPR2(1), PDGFA(2), PDGFB(1), PDGFC(1), PDGFD(3), PDGFRA(3), PDGFRB(1), PLCB1(3), PLCB2(1), PLCB4(8), PRKACA(2), PRKCA(2), PRKCG(1), PRKG1(1), PRKX(2), RAF1(1), SOS1(4), SOS2(1), TJP1(1), TUBA1A(1), TUBA3C(5), TUBA3E(1), TUBA4A(2), TUBA8(1), TUBAL3(1), TUBB1(2), TUBB2B(1), TUBB3(1), TUBB6(1), TUBB8(2) 97374256 163 105 160 62 59 26 10 49 19 0 0.431 1.000 1.000 451 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 108 ACTN1(1), ACTN2(2), ACTN4(3), ARHGAP5(4), BCAR1(3), CDH5(5), CLDN1(1), CLDN10(1), CLDN15(1), CLDN16(1), CLDN20(1), CLDN23(2), CLDN9(2), CTNNA1(2), CTNNA2(5), CTNNA3(2), CTNND1(1), CYBB(2), ESAM(1), GNAI1(2), GNAI2(2), ICAM1(1), ITGA4(3), ITGAL(5), ITGAM(3), ITGB2(2), ITK(3), JAM2(1), MAPK12(1), MAPK13(1), MLLT4(5), MMP9(5), MSN(1), MYL5(1), NCF1(1), NCF2(3), NCF4(3), NOX3(5), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIK3R1(2), PIK3R2(3), PIK3R3(2), PIK3R5(2), PLCG1(1), PLCG2(3), PRKCA(2), PRKCG(1), PTK2(3), PTPN11(1), PXN(1), RAC1(1), RAC2(1), RAP1A(1), RAPGEF3(1), RAPGEF4(3), RASSF5(1), RHOA(2), ROCK1(5), ROCK2(1), SIPA1(5), VAV1(3), VAV2(3), VAV3(4), VCAM1(2), VCL(1) 88340110 158 104 155 58 59 18 18 35 28 0 0.478 1.000 1.000 452 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 66 ADCY1(2), ADCY8(7), ARAF(1), ATF4(1), CACNA1C(4), CALM1(1), CALML3(1), CALML6(1), CAMK2A(1), CAMK2D(2), CAMK4(4), CREBBP(8), EP300(7), GRIA1(12), GRIA2(5), GRIN1(3), GRIN2A(11), GRIN2B(8), GRIN2C(3), GRM1(9), GRM5(5), HRAS(4), ITPR1(4), ITPR2(8), ITPR3(6), KRAS(2), MAPK1(1), PLCB1(3), PLCB2(1), PLCB4(8), PPP1CA(1), PPP1R12A(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKACA(2), PRKCA(2), PRKCG(1), PRKX(2), RAF1(1), RAP1A(1), RAPGEF3(1), RPS6KA1(2), RPS6KA2(2), RPS6KA6(1) 71780130 155 104 150 52 51 22 10 51 21 0 0.308 1.000 1.000 453 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(3), AKT3(1), BCAR1(3), CAPN1(2), CAPN10(1), CAPN11(5), CAPN2(2), CAPN3(1), CAPN5(1), CAPN6(1), CAPN7(1), CAPNS1(2), CAV1(1), CAV3(1), CRK(1), DOCK1(4), FYN(1), GIT2(2), GRB2(1), ILK(1), ITGA10(5), ITGA11(3), ITGA2(5), ITGA2B(5), ITGA3(2), ITGA4(3), ITGA6(2), ITGA7(4), ITGA8(3), ITGA9(4), ITGAD(5), ITGAE(1), ITGAL(5), ITGAM(3), ITGAV(3), ITGAX(3), ITGB2(2), ITGB4(4), ITGB5(1), ITGB6(6), ITGB7(1), ITGB8(2), MAP2K3(1), MAP2K6(1), MAPK12(1), MYLK2(4), PAK1(1), PAK2(2), PAK3(1), PAK6(3), PDPK1(1), PIK3R2(3), PTK2(3), PXN(1), RAC1(1), RAC2(1), RAC3(2), RAPGEF1(4), RHO(1), ROCK1(5), ROCK2(1), SHC1(3), SHC3(1), SORBS1(3), SOS1(4), TLN1(4), TNS1(6), VAV2(3), VAV3(4), VCL(1) 98316300 173 104 170 52 47 31 13 52 30 0 0.0736 1.000 1.000 454 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(1), ACTN2(2), ACTN4(3), DMD(5), MYBPC1(2), MYBPC2(5), MYBPC3(3), MYH3(3), MYH6(10), MYH7(7), MYH8(11), MYL1(1), MYOM1(5), NEB(9), TCAP(2), TNNI1(1), TNNT3(1), TPM1(1), TPM2(1), TPM4(1), TTN(87), VIM(1) 99952471 162 103 161 44 52 27 24 39 18 2 0.0391 1.000 1.000 455 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 74 ACP1(1), ACTB(1), ACTG1(2), ACTN1(1), ACTN2(2), ACTN4(3), ACVR1B(2), ACVR1C(1), BAIAP2(1), CDH1(4), CREBBP(8), CSNK2A2(1), CSNK2B(1), CTNNA1(2), CTNNA2(5), CTNNA3(2), CTNND1(1), EGFR(3), EP300(7), ERBB2(6), FARP2(3), FER(1), FGFR1(2), FYN(1), IGF1R(4), IQGAP1(3), LEF1(2), LMO7(1), MAP3K7(2), MAPK1(1), MET(4), MLLT4(5), NLK(1), PARD3(3), PTPN1(2), PTPRB(5), PTPRF(5), PTPRJ(1), PTPRM(1), PVRL1(2), PVRL2(2), PVRL3(1), PVRL4(1), RAC1(1), RAC2(1), RAC3(2), RHOA(2), SMAD2(2), SMAD3(1), SMAD4(7), SNAI1(1), SORBS1(3), SSX2IP(1), TCF7(1), TCF7L1(1), TCF7L2(2), TGFBR1(2), TJP1(1), VCL(1), WAS(2), WASF1(2), WASF2(2), WASF3(1), YES1(1) 87008286 144 94 142 44 45 22 17 40 20 0 0.146 1.000 1.000 456 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 98 ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(3), ADCY5(2), ADCY6(2), ADCY8(7), ADCY9(5), CALM1(1), CALML3(1), CALML6(1), CAMK2A(1), CAMK2D(2), CREB1(1), CREB3L1(1), CREB3L2(2), CREB3L3(1), CREB3L4(2), CREBBP(8), DVL1(1), DVL2(3), DVL3(1), EP300(7), FZD1(2), FZD10(2), FZD2(4), FZD4(2), FZD5(4), FZD6(3), FZD7(3), FZD9(2), GNAI1(2), GNAI2(2), GNAO1(1), GNAS(2), GSK3B(1), HRAS(4), KIT(3), KRAS(2), LEF1(2), MAPK1(1), MITF(1), PLCB1(3), PLCB2(1), PLCB4(8), POMC(2), PRKACA(2), PRKCA(2), PRKCG(1), PRKX(2), RAF1(1), TCF7(1), TCF7L1(1), TCF7L2(2), TYR(2), TYRP1(1), WNT1(1), WNT2(2), WNT2B(1), WNT3A(1), WNT4(1), WNT5A(1), WNT5B(1), WNT6(3), WNT7A(2), WNT9A(2) 78942312 147 92 145 74 55 28 13 33 18 0 0.851 1.000 1.000 457 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 71 CALM1(1), CALML3(1), CALML6(1), CDS1(3), CDS2(1), DGKA(1), DGKB(3), DGKD(4), DGKE(1), DGKH(2), DGKI(6), DGKQ(1), DGKZ(3), IMPA1(2), INPP4A(2), INPP4B(3), INPP5A(1), INPP5B(2), INPP5D(3), INPP5E(2), INPPL1(1), ITPK1(1), ITPKB(2), ITPR1(4), ITPR2(8), ITPR3(6), OCRL(3), PI4KA(4), PI4KB(2), PIK3C2A(2), PIK3C2B(5), PIK3C2G(1), PIK3C3(1), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIK3R1(2), PIK3R2(3), PIK3R3(2), PIK3R5(2), PIP4K2B(2), PIP5K1B(1), PIP5K1C(2), PLCB1(3), PLCB2(1), PLCB4(8), PLCD1(1), PLCD3(1), PLCD4(1), PLCE1(4), PLCG1(1), PLCG2(3), PLCZ1(3), PRKCA(2), PRKCG(1), SYNJ1(3), SYNJ2(3) 89295161 147 91 147 51 46 28 14 35 24 0 0.290 1.000 1.000 458 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(3), ADCY5(2), ADCY6(2), ADCY8(7), ADCY9(5), ATF4(1), CACNA1C(4), CACNA1D(4), CACNA1F(2), CACNA1S(4), CALM1(1), CALML3(1), CALML6(1), CAMK2A(1), CAMK2D(2), CGA(1), EGFR(3), GNA11(1), GNAS(2), GNRHR(4), GRB2(1), HRAS(4), ITPR1(4), ITPR2(8), ITPR3(6), KRAS(2), MAP2K3(1), MAP2K4(4), MAP2K6(1), MAP2K7(4), MAP3K1(5), MAP3K3(1), MAP3K4(3), MAPK1(1), MAPK12(1), MAPK13(1), MMP14(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCB1(3), PLCB2(1), PLCB4(8), PLD1(3), PLD2(2), PRKACA(2), PRKCA(2), PRKX(2), RAF1(1), SOS1(4), SOS2(1) 92824624 145 91 143 56 45 28 8 39 25 0 0.541 1.000 1.000 459 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1B(2), ACVR1C(1), ACVR2A(2), ACVRL1(3), BMP2(2), BMP4(1), BMP5(4), BMP6(1), BMP7(3), BMP8B(1), BMPR1A(2), BMPR1B(2), BMPR2(3), CHRD(1), COMP(2), CREBBP(8), CUL1(2), DCN(2), EP300(7), FST(1), GDF6(1), GDF7(2), INHBA(2), INHBC(2), INHBE(1), LEFTY1(1), LTBP1(5), MAPK1(1), MYC(1), NODAL(1), PITX2(3), PPP2CA(2), PPP2CB(1), PPP2R1B(2), PPP2R2A(1), PPP2R2B(4), PPP2R2C(1), RBL1(2), RBL2(2), RHOA(2), ROCK1(5), ROCK2(1), RPS6KB2(2), SMAD2(2), SMAD3(1), SMAD4(7), SMAD6(2), SMAD7(1), SMAD9(1), SMURF1(1), SMURF2(1), SP1(2), TFDP1(2), TGFB2(2), TGFBR1(2), THBS1(3), THBS2(1), THBS3(3), THBS4(4), TNF(1), ZFYVE16(3), ZFYVE9(1) 72899279 135 90 132 39 35 25 22 34 19 0 0.0837 1.000 1.000 460 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 124 ARAF(1), CD247(1), CD48(4), FAS(1), FASLG(1), FYN(1), GRB2(1), HLA-A(1), HLA-G(2), HRAS(4), ICAM1(1), ICAM2(2), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(2), IFNB1(1), IFNGR2(1), ITGAL(5), ITGB2(2), KIR3DL1(2), KLRC1(1), KRAS(2), LCP2(2), MAPK1(1), MICB(1), NCR1(1), NCR2(1), NFAT5(1), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), PAK1(1), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIK3R1(2), PIK3R2(3), PIK3R3(2), PIK3R5(2), PLCG1(1), PLCG2(3), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRF1(2), PRKCA(2), PRKCG(1), PTPN11(1), RAC1(1), RAC2(1), RAC3(2), RAF1(1), SH2D1B(1), SH3BP2(3), SHC1(3), SHC2(1), SHC3(1), SHC4(1), SOS1(4), SOS2(1), SYK(2), TNF(1), TNFRSF10A(1), TNFRSF10B(2), TNFRSF10C(1), TNFRSF10D(1), ULBP1(1), VAV1(3), VAV2(3), VAV3(4), ZAP70(6) 80620264 138 88 135 55 51 16 18 28 25 0 0.610 1.000 1.000 461 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(6), AMY2A(1), AMY2B(2), ASCC3(1), ATP13A2(1), DDX18(1), DDX23(6), DDX41(4), DDX47(3), DDX50(4), DDX56(2), ENPP1(3), ENPP3(2), ENTPD7(1), EP400(4), ERCC2(3), ERCC3(1), G6PC(1), G6PC2(1), GAA(1), GANC(3), GBE1(2), GCK(4), GYS1(4), HK1(2), HK2(4), HK3(4), MGAM(4), MOV10L1(2), PGM3(1), PYGB(4), PYGL(4), PYGM(1), RAD54B(4), RAD54L(2), RUVBL2(3), SETX(6), SI(6), SKIV2L2(4), SMARCA2(3), SMARCA5(3), UGDH(2), UGP2(1), UGT1A1(2), UGT1A10(1), UGT1A4(1), UGT1A7(2), UGT1A9(2), UGT2A1(1), UGT2A3(3), UGT2B10(4), UGT2B11(2), UGT2B15(3), UGT2B17(1), UGT2B28(2), UGT2B4(1), UGT2B7(3) 91255905 149 86 148 50 37 25 25 40 22 0 0.354 1.000 1.000 462 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 82 ABL1(5), AKT1(3), AKT2(1), AKT3(1), ARAF(1), CAMK2A(1), CAMK2D(2), CBL(1), CBLB(1), CBLC(1), CDKN1A(2), CRK(1), EGF(3), EGFR(3), ERBB2(6), ERBB3(5), ERBB4(4), GAB1(1), GRB2(1), GSK3B(1), HRAS(4), KRAS(2), MAP2K4(4), MAP2K7(4), MAPK1(1), MYC(1), NRG1(4), NRG2(4), NRG3(3), PAK1(1), PAK2(2), PAK3(1), PAK6(3), PAK7(3), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIK3R1(2), PIK3R2(3), PIK3R3(2), PIK3R5(2), PLCG1(1), PLCG2(3), PRKCA(2), PRKCG(1), PTK2(3), RAF1(1), RPS6KB2(2), SHC1(3), SHC2(1), SHC3(1), SHC4(1), SOS1(4), SOS2(1), STAT5B(2) 72466475 131 86 128 48 45 20 14 29 23 0 0.399 1.000 1.000 463 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 106 ABL1(5), ANAPC1(4), ANAPC2(4), ANAPC4(1), ANAPC5(3), ANAPC7(1), ATR(3), BUB1(2), BUB1B(3), BUB3(1), CCNA1(1), CCNB2(1), CCND3(1), CCNE2(1), CCNH(1), CDC14B(2), CDC16(1), CDC20(2), CDC23(3), CDC25A(4), CDC25B(5), CDC27(2), CDC6(1), CDC7(2), CDK7(2), CDKN1A(2), CDKN2A(1), CREBBP(8), CUL1(2), DBF4(1), E2F1(3), E2F3(1), EP300(7), ESPL1(3), FZR1(4), GSK3B(1), HDAC1(1), HDAC2(1), MAD1L1(4), MAD2L1(2), MAD2L2(1), MCM2(1), MCM3(4), MCM4(2), MCM5(1), MCM6(4), MCM7(1), MDM2(1), PCNA(2), PLK1(1), PRKDC(11), PTTG1(1), RB1(3), RBL1(2), RBL2(2), SMAD2(2), SMAD3(1), SMAD4(7), SMC1A(1), SMC1B(1), TFDP1(2), TGFB2(2), WEE1(1), YWHAB(1), YWHAQ(2), YWHAZ(1) 94381475 155 86 155 39 46 23 26 32 27 1 0.0253 1.000 1.000 464 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 109 ADA(1), ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(3), ADCY5(2), ADCY6(2), ADCY8(7), ADSL(1), ADSS(1), AK2(1), AK5(1), ALLC(1), AMPD1(4), AMPD2(4), AMPD3(1), APRT(1), ATIC(5), ATP5A1(2), ATP5C1(1), ATP5F1(1), ATP5G1(1), ATP5G3(1), ATP5J(1), DGUOK(1), ENPP1(3), ENPP3(2), ENTPD1(1), FHIT(1), GART(1), GUCY1A2(4), GUCY1A3(1), GUCY2C(6), GUCY2D(1), GUCY2F(3), NME1(1), NPR1(1), NPR2(1), NT5E(1), NT5M(1), PAPSS2(1), PDE4A(3), PDE4C(1), PDE5A(1), PDE6B(2), PDE6C(1), PDE8A(5), PDE9A(4), PFAS(2), PKLR(1), POLD1(3), POLD2(1), POLE(6), POLG(2), POLL(1), POLQ(6), POLR1B(3), POLR2A(6), POLR2B(4), POLR2C(1), POLR2E(1), POLRMT(1), PPAT(1), PRPS1L1(4), RRM2(1) 93838956 141 84 141 60 47 29 17 30 18 0 0.790 1.000 1.000 465 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 75 ABL1(5), ACTN1(1), ACTR3(1), AKT1(3), AKT2(1), AKT3(1), ANGPTL2(1), ARHGEF6(1), ARHGEF7(1), BCAR1(3), CAV1(1), CDKN2A(1), CRK(1), CSE1L(1), DOCK1(4), EPHB2(4), FYN(1), GRB2(1), GRB7(2), ILK(1), ITGA1(2), ITGA10(5), ITGA11(3), ITGA2(5), ITGA3(2), ITGA4(3), ITGA6(2), ITGA7(4), ITGA8(3), ITGA9(4), MAP2K4(4), MAP2K7(4), MAP3K11(1), MAPK1(1), MAPK8IP3(4), MRAS(2), MYLK(4), MYLK2(4), P4HB(1), PAK1(1), PAK2(2), PAK3(1), PAK6(3), PAK7(3), PIK3CB(3), PKLR(1), PLCG1(1), PLCG2(3), PTK2(3), RAF1(1), RHO(1), ROCK1(5), ROCK2(1), SHC1(3), SOS1(4), SOS2(1), TERF2IP(1), TLN1(4), TLN2(5), WAS(2) 86597694 142 84 140 52 39 24 13 38 28 0 0.496 1.000 1.000 466 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(2), ADCY2(4), ADCY3(2), ADCY4(3), ADCY5(2), ADCY6(2), ADCY8(7), ADCY9(5), AKAP1(4), AKAP10(1), AKAP11(3), AKAP12(6), AKAP2(1), AKAP3(2), AKAP4(2), AKAP5(1), AKAP6(3), AKAP8(1), AKAP9(10), ARHGEF1(5), CALM1(1), GNA11(1), GNA13(2), GNA14(1), GNAI2(2), GNAL(3), GNAO1(1), GNAZ(3), GNB1(1), GNB2(1), GNB3(2), GNB5(1), GNGT1(1), HRAS(4), ITPR1(4), KRAS(2), PDE1B(1), PDE1C(3), PDE4A(3), PDE4C(1), PDE7A(1), PDE8A(5), PDE8B(1), PPP3CA(2), PPP3CC(2), PRKACA(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), PRKCA(2), PRKCE(2), PRKCG(1), PRKCH(1), PRKCI(1), PRKCQ(3), PRKCZ(3), PRKD1(2), PRKD3(1), RHOA(2), SLC9A1(2), USP5(1) 86151886 145 82 142 51 53 20 15 37 20 0 0.337 1.000 1.000 467 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 81 ACVR1B(2), ACVRL1(3), AKT1(3), AURKB(2), BMPR1A(2), BMPR2(3), BUB1(2), CDKL1(1), CDKL2(5), CDS1(3), CDS2(1), CLK1(2), CLK2(1), COL4A3BP(3), CSNK2A2(1), CSNK2B(1), DGKA(1), DGKB(3), DGKD(4), DGKE(1), DGKH(2), DGKQ(1), DGKZ(3), IMPA1(2), INPP4A(2), INPP4B(3), INPP5A(1), INPPL1(1), ITPKB(2), MAP3K10(4), MOS(1), NEK1(3), OCRL(3), PIK3C2A(2), PIK3C2B(5), PIK3C2G(1), PIK3CB(3), PIK3CG(7), PLCB1(3), PLCB2(1), PLCB4(8), PLCD1(1), PLCG1(1), PLCG2(3), PLK3(3), PRKACA(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), PRKCA(2), PRKCE(2), PRKCG(1), PRKCH(1), PRKCQ(3), PRKCZ(3), PRKD1(2), PRKG1(1), RAF1(1), RPS6KA1(2), RPS6KA2(2), RPS6KA4(3), STK11(1), TGFBR1(2) 81153616 145 82 144 44 43 26 21 36 19 0 0.103 1.000 1.000 468 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 80 ABL1(5), BUB1(2), BUB1B(3), BUB3(1), CCNA1(1), CCNB2(1), CCND3(1), CCNE2(1), CCNH(1), CDAN1(1), CDC14B(2), CDC20(2), CDC25A(4), CDC25B(5), CDC6(1), CDC7(2), CDH1(4), CDKN1A(2), CDKN2A(1), DTX4(2), E2F1(3), E2F3(1), EP300(7), ESPL1(3), GSK3B(1), HDAC1(1), HDAC2(1), HDAC3(2), HDAC4(3), HDAC5(4), HDAC6(4), HDAC8(2), MAD1L1(4), MAD2L1(2), MAD2L2(1), MCM2(1), MCM3(4), MCM4(2), MCM5(1), MCM6(4), MCM7(1), MDM2(1), MPEG1(5), PCNA(2), PLK1(1), PRKDC(11), PTPRA(5), PTTG1(1), RB1(3), RBL1(2), SMAD4(7), TFDP1(2), WEE1(1) 75201356 135 79 135 31 41 24 18 30 21 1 0.0110 1.000 1.000 469 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(8), ABCA10(1), ABCA12(5), ABCA13(14), ABCA2(2), ABCA3(3), ABCA4(4), ABCA5(5), ABCA6(1), ABCA7(4), ABCA8(3), ABCA9(5), ABCB1(8), ABCB10(1), ABCB11(3), ABCB4(2), ABCB5(4), ABCB6(1), ABCB7(1), ABCB8(2), ABCB9(1), ABCC1(1), ABCC10(3), ABCC11(6), ABCC12(5), ABCC2(1), ABCC3(2), ABCC4(3), ABCC5(4), ABCC6(2), ABCC8(4), ABCC9(3), ABCD2(1), ABCD3(1), ABCG1(2), ABCG2(3), ABCG4(3), CFTR(3), TAP1(3), TAP2(1) 86750508 129 79 129 56 43 25 15 21 24 1 0.605 1.000 1.000 470 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 73 AKT1(3), AKT2(1), AKT3(1), BTK(1), FCER1A(1), FYN(1), GAB2(5), GRB2(1), HRAS(4), IL4(1), INPP5D(3), KRAS(2), LCP2(2), LYN(2), MAP2K3(1), MAP2K4(4), MAP2K6(1), MAP2K7(4), MAPK1(1), MAPK12(1), MAPK13(1), MS4A2(1), PDK1(2), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIK3R1(2), PIK3R2(3), PIK3R3(2), PIK3R5(2), PLA2G12B(1), PLA2G2A(1), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCG1(1), PLCG2(3), PRKCA(2), PRKCE(2), RAC1(1), RAC2(1), RAC3(2), RAF1(1), SOS1(4), SOS2(1), SYK(2), TNF(1), VAV1(3), VAV2(3), VAV3(4) 51501747 108 79 105 34 33 15 14 28 18 0 0.238 1.000 1.000 471 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 91 AKT1(3), AKT2(1), AKT3(1), CARD11(5), CBL(1), CBLB(1), CBLC(1), CD247(1), CD28(2), CD3D(1), CD4(1), CD40LG(1), CD8A(1), CD8B(2), FYN(1), GRB2(1), HRAS(4), IKBKB(1), IL10(1), IL4(1), ITK(3), KRAS(2), LCP2(2), MAP3K8(1), NFAT5(1), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(3), NFKBIB(2), NFKBIE(1), PAK1(1), PAK2(2), PAK3(1), PAK6(3), PAK7(3), PDCD1(1), PDK1(2), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIK3R1(2), PIK3R2(3), PIK3R3(2), PIK3R5(2), PLCG1(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKCQ(3), PTPRC(8), RHOA(2), SOS1(4), SOS2(1), TEC(1), TNF(1), VAV1(3), VAV2(3), VAV3(4), ZAP70(6) 73188047 131 78 127 45 42 19 15 34 21 0 0.312 1.000 1.000 472 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 107 A4GNT(1), ALG10B(3), ALG12(1), ALG13(1), ALG14(2), ALG8(1), ALG9(1), B3GNT1(1), B3GNT7(2), B4GALT1(2), B4GALT2(2), B4GALT3(1), B4GALT4(1), B4GALT5(1), CHPF(1), CHST1(1), CHST11(3), CHST12(1), CHST13(1), CHST2(1), CHST3(3), CHST4(1), CHSY1(1), DDOST(1), EXT1(3), EXT2(3), EXTL1(3), EXTL3(4), FUT8(2), GALNT10(5), GALNT11(2), GALNT12(2), GALNT13(1), GALNT14(3), GALNT2(1), GALNT3(5), GALNT4(1), GALNT8(2), GALNTL5(3), GANAB(3), GCNT1(2), GCNT3(1), GCNT4(1), HS2ST1(1), HS3ST3A1(1), HS6ST1(3), HS6ST2(1), MAN1A1(2), MAN1B1(1), MAN1C1(1), MAN2A1(4), MGAT3(1), MGAT4A(1), MGAT5(1), MGAT5B(2), NDST1(3), NDST2(5), NDST3(3), NDST4(6), OGT(1), RPN1(1), RPN2(2), ST3GAL1(2), ST3GAL3(1), ST6GAL1(1), ST6GALNAC1(1), UST(1), WBSCR17(2), XYLT1(6), XYLT2(1) 80618444 136 77 136 45 47 23 15 29 22 0 0.237 1.000 1.000 473 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(2), BDKRB1(3), BDKRB2(2), C1QB(1), C1S(4), C2(1), C3(3), C3AR1(2), C4BPA(2), C5(3), C6(5), C8A(3), C8B(2), C9(3), CD46(2), CFB(3), CFD(1), CFH(9), CFI(1), CPB2(1), CR1(1), CR2(2), F10(3), F11(4), F12(1), F13A1(4), F13B(3), F2(2), F2R(2), F3(1), F5(5), F7(2), F8(1), FGA(5), FGB(2), FGG(1), KLKB1(2), MASP1(2), MASP2(2), PLAT(3), PLG(1), PROC(3), PROS1(3), SERPINA1(1), SERPINC1(2), SERPIND1(2), SERPINF2(1), SERPING1(2), VWF(6) 66545774 122 75 121 56 40 16 10 35 20 1 0.940 1.000 1.000 474 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(1), CABIN1(1), CALM1(1), CAMK4(4), CD69(2), CDKN1A(2), CEBPB(1), CNR1(5), CREBBP(8), CSNK2B(1), EGR3(1), EP300(7), FCER1A(1), GATA4(1), GSK3A(3), GSK3B(1), HRAS(4), IFNB1(1), IL10(1), IL4(1), IL6(1), ITK(3), KPNA5(3), MAP2K7(4), MEF2A(1), MEF2D(1), MYF5(1), NFAT5(1), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), NFKBIB(2), NFKBIE(1), NUP214(5), OPRD1(1), PAK1(1), PPIA(1), PPP3CB(1), PPP3CC(2), PTPRC(8), RELA(3), SP1(2), SP3(3), TNF(1), TRAF2(5), TRPV6(2), VAV1(3), VAV2(3), VAV3(4), XPO5(2) 67036779 118 74 116 41 37 18 13 33 17 0 0.336 1.000 1.000 475 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ADORA3(3), CCKBR(2), CCR2(3), CCR3(1), CCR5(2), CELSR1(4), CELSR2(11), CELSR3(9), CHRM2(2), CHRM3(1), DRD4(1), EDNRA(1), EMR2(7), F2R(2), FSHR(2), GHRHR(1), GNRHR(4), GPR116(2), GPR132(1), GPR133(2), GPR17(2), GPR18(2), GPR55(2), GPR56(1), GPR84(1), GRM1(9), GRPR(1), HRH4(2), LGR6(3), LPHN2(6), LPHN3(9), NTSR1(3), OR2M4(2), P2RY11(2), SSTR2(1), TAAR5(1), TSHR(1), VN1R1(2) 48912646 111 71 109 38 46 17 10 28 10 0 0.0894 1.000 1.000 476 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 61 AKT1(3), AKT2(1), AKT3(1), BTK(1), CARD11(5), CD72(1), CD79A(2), CD81(2), CR2(2), GSK3B(1), HRAS(4), IKBKB(1), INPP5D(3), KRAS(2), LYN(2), NFAT5(1), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), NFKB1(3), NFKBIB(2), NFKBIE(1), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIK3R1(2), PIK3R2(3), PIK3R3(2), PIK3R5(2), PLCG2(3), PPP3CA(2), PPP3CB(1), PPP3CC(2), RAC1(1), RAC2(1), RAC3(2), SYK(2), VAV1(3), VAV2(3), VAV3(4) 53145233 92 67 89 40 28 13 14 21 16 0 0.762 1.000 1.000 477 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 45 AKT1(3), AKT2(1), AKT3(1), BCR(2), BTK(1), CD81(2), CR2(2), DAG1(2), GRB2(1), GSK3A(3), GSK3B(1), INPP5D(3), ITPR1(4), ITPR2(8), ITPR3(6), LYN(2), MAP4K1(2), MAPK1(1), NFATC1(2), NFATC2(2), PDK1(2), PIK3CD(5), PIK3R1(2), PLCG2(3), PPP1R13B(3), PPP3CA(2), PPP3CB(1), PPP3CC(2), PTPRC(8), RAF1(1), SHC1(3), SOS1(4), SOS2(1), SYK(2), VAV1(3) 52860187 91 67 90 35 29 14 7 22 19 0 0.575 1.000 1.000 478 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 77 AKT1(3), AKT2(1), AKT3(1), APAF1(2), BIRC2(1), CAPN1(2), CAPN2(2), CASP10(1), CASP8(1), CASP9(1), CFLAR(2), CSF2RB(1), DFFA(4), FAS(1), FASLG(1), IKBKB(1), IL1A(1), IL1RAP(2), IL3RA(3), IRAK1(1), IRAK2(4), IRAK3(4), IRAK4(2), NFKB1(3), NTRK1(9), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIK3R1(2), PIK3R2(3), PIK3R3(2), PIK3R5(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKACA(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), RELA(3), RIPK1(1), TNF(1), TNFRSF10A(1), TNFRSF10B(2), TNFRSF10C(1), TNFRSF10D(1), TNFRSF1A(1), TRAF2(5) 54404572 108 66 107 37 36 23 9 25 15 0 0.297 1.000 1.000 479 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 97 AKT1(3), AKT2(1), AKT3(1), CASP8(1), CD14(2), CD40(1), CD86(1), CXCL9(1), IFNA10(1), IFNA13(1), IFNA16(2), IFNA17(2), IFNB1(1), IKBKB(1), IKBKE(1), IL12A(1), IL12B(1), IL6(1), IRAK1(1), IRAK4(2), IRF3(1), IRF5(1), LY96(1), MAP2K3(1), MAP2K4(4), MAP2K6(1), MAP2K7(4), MAP3K7(2), MAP3K8(1), MAPK1(1), MAPK12(1), MAPK13(1), NFKB1(3), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIK3R1(2), PIK3R2(3), PIK3R3(2), PIK3R5(2), RAC1(1), RELA(3), RIPK1(1), STAT1(1), TBK1(1), TICAM1(1), TIRAP(1), TLR1(1), TLR2(2), TLR4(2), TLR5(2), TLR7(3), TLR8(2), TLR9(1), TNF(1), TRAF6(2) 64474962 97 66 95 44 29 16 12 23 17 0 0.823 1.000 1.000 480 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 82 ANPEP(2), CD14(2), CD1B(3), CD1C(4), CD1D(1), CD1E(1), CD2(1), CD34(1), CD36(1), CD37(1), CD38(1), CD3D(1), CD4(1), CD8A(1), CD8B(2), CD9(1), CR1(1), CR2(2), CSF1(1), CSF1R(5), CSF2RA(3), CSF3R(1), DNTT(1), EPOR(1), FCGR1A(1), FLT3(2), FLT3LG(1), GP5(4), GP9(1), HLA-DRA(1), HLA-DRB5(1), IL11RA(1), IL1A(1), IL1R2(1), IL3RA(3), IL4(1), IL4R(3), IL6(1), IL7(2), IL7R(1), ITGA1(2), ITGA2(5), ITGA2B(5), ITGA3(2), ITGA4(3), ITGA6(2), ITGAM(3), KIT(3), MME(2), TFRC(1), THPO(1), TNF(1), TPO(5) 59849115 99 65 99 42 27 20 6 31 15 0 0.700 1.000 1.000 481 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(3), ACSL1(3), ACSL5(1), ACSL6(3), ADIPOQ(1), ADIPOR1(2), ADIPOR2(1), AKT1(3), AKT2(1), AKT3(1), CAMKK1(2), CD36(1), CPT1A(1), CPT1B(2), CPT1C(5), CPT2(2), G6PC(1), G6PC2(1), IKBKB(1), IRS1(3), IRS2(2), IRS4(3), JAK1(6), JAK2(1), JAK3(1), LEPR(2), NFKB1(3), NFKBIB(2), NFKBIE(1), PCK2(2), POMC(2), PPARA(2), PPARGC1A(4), PRKAA2(5), PRKAG1(3), PRKAG3(1), PRKCQ(3), PTPN11(1), RELA(3), RXRA(2), RXRB(2), RXRG(2), SLC2A1(1), STAT3(6), STK11(1), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRAF2(5), TYK2(2) 60970844 109 65 107 35 38 24 13 22 12 0 0.112 1.000 1.000 482 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 83 ATF2(3), CREB1(1), DAXX(2), GRB2(1), HRAS(4), IKBKB(1), MAP2K3(1), MAP2K4(4), MAP2K6(1), MAP2K7(4), MAP3K1(5), MAP3K10(4), MAP3K11(1), MAP3K12(3), MAP3K13(3), MAP3K3(1), MAP3K4(3), MAP3K5(2), MAP3K7(2), MAP3K8(1), MAP3K9(4), MAP4K1(2), MAP4K2(1), MAP4K4(1), MAP4K5(1), MAPK1(1), MAPK12(1), MAPK13(1), MAPKAPK3(1), MAPKAPK5(1), MEF2A(1), MEF2C(3), MEF2D(1), MYC(1), NFKB1(3), PAK1(1), PAK2(2), RAC1(1), RAF1(1), RELA(3), RIPK1(1), RPS6KA1(2), RPS6KA2(2), RPS6KA4(3), RPS6KA5(3), RPS6KB2(2), SHC1(3), SP1(2), STAT1(1), TGFB2(2), TGFBR1(2), TRAF2(5) 68485902 106 64 104 39 33 20 15 18 19 1 0.450 1.000 1.000 483 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 42 ACTR3(1), AKT1(3), AKT2(1), AKT3(1), ANGPTL2(1), ARHGAP1(1), ARHGEF11(2), BTK(1), CFL1(1), GDI1(1), INPPL1(1), ITPR1(4), ITPR2(8), ITPR3(6), LIMK1(2), MYLK(4), MYLK2(4), PAK1(1), PAK2(2), PAK3(1), PAK6(3), PAK7(3), PDK1(2), PIK3CD(5), PIK3CG(7), PIK3R1(2), PITX2(3), PPP1R13B(3), RACGAP1(1), RHO(1), ROCK1(5), ROCK2(1), SAG(2), WASF1(2) 49380235 86 61 84 33 26 12 8 23 17 0 0.727 1.000 1.000 484 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 CREBBP(8), DLL1(3), DLL3(3), DLL4(2), DTX1(5), DTX2(2), DTX3L(2), DTX4(2), DVL1(1), DVL2(3), DVL3(1), EP300(7), HDAC1(1), HDAC2(1), JAG1(1), JAG2(4), LFNG(1), MAML1(1), MAML2(2), MAML3(1), MFNG(1), NCOR2(7), NCSTN(2), NOTCH1(6), NOTCH2(7), NOTCH3(4), NOTCH4(4), NUMB(1), NUMBL(1), PTCRA(1), RBPJ(1), RBPJL(1), SNW1(3) 50702534 90 60 90 37 33 14 9 15 18 1 0.626 1.000 1.000 485 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 68 AKT1(3), AKT2(1), AKT3(1), CASP9(1), HRAS(4), KDR(7), KRAS(2), MAPK1(1), MAPK12(1), MAPK13(1), MAPKAPK3(1), NFAT5(1), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), NOS3(2), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIK3R1(2), PIK3R2(3), PIK3R3(2), PIK3R5(2), PLA2G12B(1), PLA2G2A(1), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCG1(1), PLCG2(3), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKCA(2), PRKCG(1), PTGS2(5), PTK2(3), PXN(1), RAC1(1), RAC2(1), RAC3(2), RAF1(1), SH2D2A(1), SHC2(1), SPHK1(1), SPHK2(1), VEGFA(2) 51245431 97 60 94 32 28 16 13 17 22 1 0.245 1.000 1.000 486 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 91 CDC40(1), CLK2(1), CLK3(3), COL2A1(1), CPSF1(1), CPSF2(1), CSTF2T(5), CSTF3(3), DDX1(1), DHX15(3), DHX16(2), DHX38(3), DHX8(2), DHX9(1), DICER1(1), METTL3(2), NONO(2), NXF1(1), PHF5A(1), POLR2A(6), PPM1G(2), PRPF3(1), PRPF4(2), PRPF4B(3), PRPF8(5), PSKH1(2), PTBP1(6), RBM17(1), RBM5(4), RNGTT(1), RNMT(4), SF3A1(3), SF3A2(2), SF3A3(1), SF3B1(4), SF3B4(1), SF3B5(1), SNRPA1(2), SNRPB2(1), SNRPD2(1), SNRPD3(1), SNRPG(1), SNRPN(2), SRPK1(1), SRRM1(1), SUPT5H(3), U2AF1(1), U2AF2(1) 77047333 99 60 99 28 24 17 16 20 22 0 0.274 1.000 1.000 487 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 54 ASH1L(7), ASH2L(1), CARM1(2), CTCFL(1), DOT1L(4), EED(1), EHMT1(1), EHMT2(3), EZH1(2), EZH2(1), HCFC1(3), HSF4(1), JMJD4(1), MEN1(4), NSD1(4), OGT(1), PAXIP1(2), PPP1CA(1), PRDM2(4), PRDM9(4), PRMT1(1), PRMT5(2), PRMT7(1), PRMT8(1), RBBP5(2), SATB1(1), SETD1A(3), SETD2(10), SETD7(1), SETD8(1), SETDB1(2), SETDB2(1), SETMAR(1), SUV420H1(2), SUV420H2(1), WHSC1(7), WHSC1L1(4) 85326596 89 56 89 31 32 10 7 19 21 0 0.703 1.000 1.000 488 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 85 AICDA(1), AK3(1), CAD(9), CTPS2(2), DHODH(1), DPYD(3), DPYS(2), ENTPD1(1), ENTPD3(2), ENTPD4(2), ENTPD6(2), NME1(1), NME7(1), NT5C1B(2), NT5C2(3), NT5E(1), NT5M(1), POLA1(1), POLA2(1), POLD1(3), POLD2(1), POLD3(1), POLE(6), POLE2(1), POLR1A(3), POLR1B(3), POLR1C(2), POLR2A(6), POLR2B(4), POLR2C(1), POLR2E(1), POLR3A(4), POLR3B(3), PRIM2(2), RFC5(1), RRM2(1), TXNRD1(4), TYMS(1), UCK2(3), UMPS(3), UPP1(2), UPP2(1) 58970237 94 55 94 31 31 21 10 18 14 0 0.220 1.000 1.000 489 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(2), ACAT1(2), ACAT2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH7A1(2), AOC2(3), AOC3(1), AOX1(2), ASMT(2), CARM1(2), CAT(2), CYP1A1(1), CYP1A2(1), ECHS1(1), EHHADH(5), GCDH(1), HADH(3), HEMK1(1), HSD17B4(3), INMT(1), KMO(2), KYNU(3), LCMT1(1), LCMT2(1), MAOA(2), MAOB(2), METTL6(1), NFX1(1), PRMT3(2), PRMT5(2), PRMT7(1), PRMT8(1), TDO2(1), TPH1(1), TPH2(2), WARS(1), WARS2(2) 44518359 68 54 68 28 18 11 8 19 11 1 0.771 1.000 1.000 490 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(14), B3GALT4(2), CDR1(1), DGKI(6), IL6ST(7), MRPL19(1), PIGK(1), RPL10(1), RPL11(4), RPL12(1), RPL19(2), RPL28(1), RPL29(1), RPL3(1), RPL34(1), RPL35A(1), RPL37(1), RPL3L(1), RPL5(3), RPL6(2), RPL7(2), RPL7A(1), RPL8(1), RPLP1(1), RPS10(1), RPS11(2), RPS20(1), RPS27A(2), RPS5(1), RPS6(1), RPS6KA1(2), RPS6KA2(2), RPS6KA6(1), RPS6KB2(2), RPS9(1), SLC36A2(3), UBB(1), UBC(1) 38563595 78 52 78 42 22 19 6 17 14 0 0.992 1.000 1.000 491 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY4(3), ADCY6(2), ADCY8(7), CACNA1A(12), CACNA1B(3), GNAS(2), GNB1(1), GNB3(2), GRM4(2), ITPR3(6), KCNB1(4), PLCB2(1), PRKACA(2), PRKX(2), SCNN1B(4), SCNN1G(2), TAS1R2(4), TAS1R3(1), TAS2R13(1), TAS2R16(1), TAS2R38(2), TAS2R4(1), TAS2R42(1), TAS2R43(1), TAS2R46(1), TAS2R5(1), TAS2R50(1), TRPM5(3) 41733569 73 51 73 32 34 7 8 16 8 0 0.725 1.000 1.000 492 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 57 APC(10), AXIN1(1), CCND3(1), CSNK1E(3), DVL1(1), DVL2(3), DVL3(1), FZD1(2), FZD10(2), FZD2(4), FZD5(4), FZD6(3), FZD7(3), FZD9(2), GSK3B(1), LDLR(3), MYC(1), PPP2R5E(2), PRKCA(2), PRKCE(2), PRKCG(1), PRKCH(1), PRKCI(1), PRKCQ(3), PRKCZ(3), PRKD1(2), RAC1(1), RHOA(2), TCF7(1), WNT1(1), WNT2(2), WNT2B(1), WNT4(1), WNT5A(1), WNT5B(1), WNT6(3), WNT7A(2) 43016709 78 51 77 35 25 12 8 18 15 0 0.601 1.000 1.000 493 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 63 ACHE(1), AGPAT2(1), AGPAT3(2), AGPAT4(2), AGPAT6(2), CDS1(3), CDS2(1), CHAT(4), DGKA(1), DGKB(3), DGKD(4), DGKE(1), DGKH(2), DGKI(6), DGKQ(1), DGKZ(3), ESCO1(5), ESCO2(1), ETNK1(1), GNPAT(2), GPAM(2), GPD1L(1), GPD2(1), LCAT(1), NAT6(1), PCYT1A(1), PCYT1B(1), PISD(1), PLA2G12B(1), PLA2G2A(1), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLD1(3), PLD2(2), PPAP2A(1), PPAP2B(1), PTDSS2(1), SH3GLB1(1) 47898875 73 48 73 26 17 12 8 18 18 0 0.548 1.000 1.000 494 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 58 BTK(1), CAD(9), CASP10(1), CASP8(1), DAXX(2), DEDD2(2), DFFA(4), EGFR(3), EPHB2(4), FAF1(4), IL1A(1), MAP2K4(4), MAP2K7(4), MAP3K1(5), MAP3K5(2), MAPK1(1), MAPK8IP3(4), MET(4), NFAT5(1), NFKB1(3), NFKBIB(2), NFKBIE(1), NFKBIL1(1), PFN1(1), PFN2(3), PTPN13(1), RALBP1(1), RIPK1(1), ROCK1(5), TNFRSF6B(1), TPX2(1), TRAF2(5), TUFM(1) 52825712 84 47 83 28 28 13 8 18 17 0 0.366 1.000 1.000 495 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 61 CCNA1(1), CCND3(1), CCNE2(1), CCNG2(1), CCNH(1), CDC25A(4), CDK7(2), CDKN1A(2), CDKN2A(1), CREB3L1(1), CREB3L3(1), CREB3L4(2), E2F1(3), E2F3(1), GBA2(1), MCM2(1), MCM3(4), MCM4(2), MCM5(1), MCM6(4), MCM7(1), MDM2(1), MYC(1), MYT1(2), NACA(3), PCNA(2), POLA2(1), POLE(6), POLE2(1), RB1(3), RBL1(2), RPA1(2), RPA2(1), TFDP1(2), TFDP2(1), TNXB(12), WEE1(1) 51358623 77 46 77 29 24 15 7 17 13 1 0.505 1.000 1.000 496 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 42 AKT1(3), AKT2(1), AKT3(1), CAB39(1), DDIT4(2), EIF4B(2), FIGF(1), HIF1A(2), MAPK1(1), PDPK1(1), PIK3CB(3), PIK3CD(5), PIK3CG(7), PIK3R1(2), PIK3R2(3), PIK3R3(2), PIK3R5(2), PRKAA2(5), RICTOR(1), RPS6(1), RPS6KA1(2), RPS6KA2(2), RPS6KA6(1), RPS6KB2(2), STK11(1), TSC1(2), TSC2(7), ULK1(1), ULK2(1), ULK3(2), VEGFA(2) 36263575 69 46 68 25 26 13 10 11 9 0 0.411 1.000 1.000 497 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 27 CPEB1(1), EGFR(3), ERBB2(6), ERBB4(4), ETS1(1), ETV6(1), FMN2(8), GRB2(1), KRAS(2), MAPK1(1), NOTCH1(6), NOTCH2(7), NOTCH3(4), NOTCH4(4), PIWIL1(7), PIWIL2(4), PIWIL3(2), RAF1(1), SOS1(4), SOS2(1) 37239314 68 46 68 27 21 14 7 14 12 0 0.613 1.000 1.000 498 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(1), ALPP(2), ALPPL2(2), ASCC3(1), ATP13A2(1), DDX18(1), DDX23(6), DDX41(4), DDX47(3), DDX50(4), DDX56(2), DHFR(2), ENTPD7(1), EP400(4), ERCC2(3), ERCC3(1), FPGS(1), MOV10L1(2), RAD54B(4), RAD54L(2), RUVBL2(3), SETX(6), SKIV2L2(4), SMARCA2(3), SMARCA5(3), SPR(1) 46297477 67 45 67 32 17 15 10 15 10 0 0.874 1.000 1.000 499 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 31 AKT1(3), AKT2(1), AKT3(1), BCR(2), BTK(1), CDKN2A(1), DAPP1(1), GAB1(1), ITPR1(4), ITPR2(8), ITPR3(6), LYN(2), PDK1(2), PITX2(3), PLCG2(3), PPP1R13B(3), PREX1(1), PTPRC(8), RPS6KA1(2), RPS6KA2(2), SAG(2), SYK(2), TEC(1), VAV1(3) 38406391 63 45 62 26 14 12 6 21 10 0 0.750 1.000 1.000 500 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(1), AKT1(3), BDKRB2(2), CALM1(1), CAV1(1), CHRNA1(1), FLT1(5), FLT4(4), KDR(7), NOS3(2), PDE2A(2), PDE3A(2), PDE3B(3), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), PRKG1(1), RYR2(17), SLC7A1(1), SYT1(1), TNNI1(1) 29564467 62 44 61 26 25 12 4 11 9 1 0.482 1.000 1.000 501 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(2), ACTR3(1), AKT1(3), ANGPTL2(1), CFL1(1), FLNA(1), FLNC(8), FSCN1(1), FSCN2(2), FSCN3(5), GDI1(1), LIMK1(2), MYH2(7), MYLK(4), MYLK2(4), PAK1(1), PAK2(2), PAK3(1), PAK6(3), PAK7(3), PFN1(1), PFN2(3), RHO(1), ROCK1(5), ROCK2(1), WASF1(2) 35163980 66 44 64 29 26 11 5 18 6 0 0.710 1.000 1.000 502 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 56 BMP2(2), BMP4(1), BMP5(4), BMP6(1), BMP7(3), BMP8B(1), BTRC(3), CSNK1A1L(1), CSNK1E(3), CSNK1G1(2), CSNK1G3(1), DHH(1), FBXW11(2), GLI1(5), GLI2(3), GLI3(3), GSK3B(1), HHIP(4), IHH(1), LRP2(5), PRKACA(2), PRKX(2), PTCH1(1), PTCH2(5), SHH(2), STK36(1), SUFU(1), WNT1(1), WNT2(2), WNT2B(1), WNT3A(1), WNT4(1), WNT5A(1), WNT5B(1), WNT6(3), WNT7A(2), WNT9A(2) 44787036 76 43 76 29 27 18 10 12 9 0 0.257 1.000 1.000 503 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH4A1(2), AMD1(1), AOC2(3), AOC3(1), ARG1(1), ARG2(1), CKB(1), CKMT1B(1), CKMT2(2), CPS1(4), DAO(1), GLUD1(2), GOT1(2), GOT2(1), MAOA(2), MAOB(2), NOS1(3), NOS3(2), ODC1(1), OTC(1), P4HA1(4), P4HA2(3), P4HA3(3), P4HB(1), PYCR1(2) 32392593 59 42 58 24 18 10 5 18 8 0 0.743 1.000 1.000 504 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(2), APAF1(2), ARHGDIB(1), BIRC2(1), CASP8(1), CASP9(1), CFLAR(2), DAXX(2), DFFA(4), GSN(6), LMNA(4), LMNB2(2), MAP2K7(4), MAP3K1(5), MAP3K5(2), MDM2(1), NFKB1(3), NUMA1(6), PAK2(2), PRKDC(11), PTK2(3), RASA1(1), RB1(3), RELA(3), RIPK1(1), SPTAN1(2), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRAF1(1), TRAF2(5) 50774643 84 42 84 20 28 24 5 15 11 1 0.0349 1.000 1.000 505 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(1), ACSS2(1), ADH1A(1), ADH1B(1), ADH4(1), ADH6(3), ADHFE1(1), AKR1A1(2), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH3B1(1), ALDH7A1(2), ALDOC(3), DLAT(1), DLD(2), ENO1(3), ENO2(1), ENO3(1), FBP1(2), FBP2(1), G6PC(1), G6PC2(1), GAPDH(1), GCK(4), HK1(2), HK2(4), HK3(4), LDHAL6A(1), LDHB(1), LDHC(1), PDHA1(1), PDHA2(4), PFKL(2), PFKM(3), PFKP(3), PGAM2(1), PGK2(2), PGM3(1), PKLR(1) 42831659 72 42 71 19 23 11 10 15 13 0 0.0363 1.000 1.000 506 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(3), CREB1(1), DAXX(2), GRB2(1), HRAS(4), MAP2K4(4), MAP2K6(1), MAP3K1(5), MAP3K5(2), MAP3K7(2), MAP3K9(4), MAPKAPK5(1), MEF2A(1), MEF2C(3), MEF2D(1), MYC(1), PLA2G4A(4), RAC1(1), RIPK1(1), RPS6KA5(3), SHC1(3), STAT1(1), TGFB2(2), TGFBR1(2), TRAF2(5) 26838925 58 42 56 22 19 6 10 14 9 0 0.609 1.000 1.000 507 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 54 AK3(1), CAD(9), CTPS2(2), DHODH(1), DPYD(3), DPYS(2), ENTPD1(1), NME1(1), NT5E(1), NT5M(1), POLD1(3), POLD2(1), POLE(6), POLG(2), POLL(1), POLQ(6), POLR1B(3), POLR2A(6), POLR2B(4), POLR2C(1), POLR2E(1), POLRMT(1), RRM2(1), TXNRD1(4), TYMS(1), UCK2(3), UMPS(3), UPP1(2) 41621665 71 42 71 24 23 15 10 12 11 0 0.355 1.000 1.000 508 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(2), AASDHPPT(1), AASS(3), ACAT1(2), ACAT2(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH7A1(2), BBOX1(2), DOT1L(4), ECHS1(1), EHHADH(5), EHMT1(1), EHMT2(3), GCDH(1), HADH(3), HSD17B4(3), NSD1(4), PIPOX(2), PLOD1(2), PLOD3(3), RDH12(1), SETD1A(3), SETD7(1), SETDB1(2), SHMT1(1), SHMT2(1) 42583521 60 41 60 24 23 8 7 12 10 0 0.629 1.000 1.000 509 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(2), ATP6V0A1(3), ATP6V0A2(4), ATP6V0B(1), ATP6V0D2(1), ATP6V1A(3), ATP6V1B1(2), ATP6V1C2(5), ATP6V1E2(1), ATP6V1F(1), ATP6V1H(1), EGFR(3), GIT1(1), IGSF5(1), IKBKB(1), JAM2(1), LYN(2), MAP2K4(4), MAPK12(1), MAPK13(1), MET(4), NFKB1(3), NOD1(5), PAK1(1), PLCG1(1), PLCG2(3), PTPN11(1), RAC1(1), RELA(3), TCIRG1(1), TJP1(1) 51693008 63 41 63 25 16 13 7 19 8 0 0.634 1.000 1.000 510 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 38 AKT1(3), AKT2(1), AKT3(1), BCR(2), BTK(1), DAG1(2), EPHB2(4), GRB2(1), ITPKB(2), LYN(2), MAPK1(1), NFAT5(1), NFKB1(3), NFKBIB(2), NFKBIE(1), NFKBIL1(1), PI3(1), PIK3CD(5), PIK3R1(2), PLCG2(3), PPP1R13B(3), RAF1(1), SERPINA4(1), SHC1(3), SOS1(4), SOS2(1), SYK(2), VAV1(3) 37194596 57 41 56 30 24 10 4 9 10 0 0.910 1.000 1.000 511 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 DAXX(2), EGF(3), EGFR(3), ETS1(1), HRAS(4), IKBKB(1), MAP2K3(1), MAP2K4(4), MAP2K6(1), MAP2K7(4), MAP3K1(5), MAP3K5(2), MAPK1(1), MAPK13(1), NFKB1(3), PPP2CA(2), PRKCA(2), PRKCE(2), PRKCG(1), PRKCH(1), PRKCQ(3), RAF1(1), RELA(3), RIPK1(1), SP1(2), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRAF2(5) 36103983 62 40 60 26 16 13 9 16 8 0 0.664 1.000 1.000 512 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 26 AKT1(3), AKT2(1), AKT3(1), GRB2(1), GSK3A(3), GSK3B(1), IL4R(3), IRS1(3), IRS2(2), JAK1(6), JAK3(1), MAP4K1(2), MAPK1(1), PDK1(2), PIK3CD(5), PIK3R1(2), PPP1R13B(3), RAF1(1), SHC1(3), SOS1(4), SOS2(1), STAT6(3) 25274162 52 39 51 21 16 7 3 12 14 0 0.720 1.000 1.000 513 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(1), CD28(2), CD3D(1), DAG1(2), EPHB2(4), GRB2(1), ITK(3), ITPKB(2), LCP2(2), MAPK1(1), NFAT5(1), NFKB1(3), NFKBIB(2), NFKBIE(1), NFKBIL1(1), PAK1(1), PAK2(2), PAK3(1), PAK6(3), PAK7(3), PLCG1(1), PTPRC(8), RAF1(1), RASGRP2(1), RASGRP4(1), SOS1(4), SOS2(1), VAV1(3), ZAP70(6) 41058046 63 39 63 26 29 10 5 11 8 0 0.701 1.000 1.000 514 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(3), GNAS(2), GNB1(1), GNGT1(1), GRB2(1), HRAS(4), IGF1R(4), KLK2(1), MAPK1(1), MYC(1), PDGFRA(3), PPP2CA(2), PTPRR(1), RAF1(1), RPS6KA1(2), RPS6KA5(3), SHC1(3), SOS1(4), STAT3(6) 24287253 44 38 42 17 11 5 8 15 5 0 0.659 1.000 1.000 515 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(1), ADRA1B(2), ADRA1D(2), ADRA2A(2), ADRA2C(2), ADRB1(1), CHRM2(2), CHRM3(1), CHRM4(3), DRD2(1), DRD3(2), DRD4(1), DRD5(1), HRH1(1), HRH2(1), HTR1A(3), HTR1D(2), HTR1E(6), HTR2A(2), HTR2B(2), HTR2C(3), HTR4(1), HTR5A(1), HTR6(2) 18863510 45 37 44 21 23 7 2 9 4 0 0.547 1.000 1.000 516 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(3), F11(4), F12(1), F13B(3), F2(2), F5(5), F7(2), F8(1), FGA(5), FGB(2), FGG(1), LPA(5), PLAT(3), PLG(1), SERPINB2(1), SERPINF2(1), VWF(6) 25947576 46 36 46 27 15 7 4 13 6 1 0.975 1.000 1.000 517 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(2), ARG1(1), ARG2(1), CKB(1), CKMT1B(1), CKMT2(2), CPS1(4), DAO(1), EPRS(4), GLUD1(2), GLUD2(2), GOT1(2), GOT2(1), NOS1(3), NOS3(2), OTC(1), P4HA1(4), P4HA2(3), P4HA3(3), PARS2(3), PYCR1(2), PYCR2(1), PYCRL(1), RARS2(1) 26349202 48 36 48 21 20 7 3 12 6 0 0.762 1.000 1.000 518 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(3), B3GALNT1(1), B3GALT2(2), B3GALT4(2), B3GALT5(3), B3GNT1(1), B3GNT3(3), B3GNT4(2), B3GNT5(1), B4GALNT1(3), B4GALT1(2), B4GALT2(2), B4GALT3(1), B4GALT4(1), B4GALT6(3), FUT1(1), FUT2(1), FUT3(2), FUT4(1), GBGT1(1), PIGA(1), PIGB(2), PIGC(1), PIGG(3), PIGH(1), PIGK(1), PIGO(2), PIGQ(3), PIGT(1), ST3GAL1(2), ST3GAL3(1), ST3GAL6(1), ST6GALNAC3(1), ST6GALNAC4(2), ST8SIA1(1), ST8SIA5(1) 35674533 60 36 60 23 22 9 8 14 6 1 0.615 1.000 1.000 519 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR3(1), ARHGAP1(1), ARHGAP5(4), ARHGAP6(2), ARHGEF1(5), ARHGEF11(2), ARHGEF5(4), BAIAP2(1), CFL1(1), DIAPH1(2), GSN(6), LIMK1(2), MYLK(4), PFN1(1), PIP5K1B(1), PPP1R12B(1), ROCK1(5), TLN1(4), VCL(1) 33093626 48 36 47 18 6 9 7 12 14 0 0.767 1.000 1.000 520 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(1), ALDH4A1(2), ALDH5A1(1), CAD(9), CPS1(4), EARS2(1), EPRS(4), GAD1(2), GAD2(9), GFPT2(2), GLUD1(2), GLUD2(2), GLUL(1), GNPNAT1(1), GOT1(2), GOT2(1), GSR(1), NADSYN1(1), NAGK(1), PPAT(1), QARS(1) 29114463 49 35 49 24 20 6 4 9 10 0 0.872 1.000 1.000 521 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ACY3(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH3B1(1), ALDH7A1(2), AMDHD1(3), AOC2(3), AOC3(1), ASPA(1), CARM1(2), CNDP1(3), HAL(2), HARS(1), HDC(2), HEMK1(1), LCMT1(1), LCMT2(1), MAOA(2), MAOB(2), METTL6(1), PRMT3(2), PRMT5(2), PRMT7(1), PRMT8(1), UROC1(3) 29070335 45 35 45 20 12 9 5 12 7 0 0.813 1.000 1.000 522 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 21 ARFIP2(1), CFL1(1), CHN1(1), LIMK1(2), MAP3K1(5), MYLK(4), NCF2(3), PAK1(1), PDGFRA(3), PIK3R1(2), PLD1(3), PPP1R12B(1), RAC1(1), RALBP1(1), TRIO(7), VAV1(3), WASF1(2) 24100841 41 35 41 19 15 6 3 9 8 0 0.867 1.000 1.000 523 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BTK(1), CALM1(1), CD79A(2), GRB2(1), HRAS(4), LYN(2), MAP3K1(5), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), PLCG1(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKCA(2), RAC1(1), RAF1(1), SHC1(3), SOS1(4), SYK(2), SYT1(1), VAV1(3) 28120457 45 34 43 18 17 6 6 9 7 0 0.591 1.000 1.000 524 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 25 EGF(3), EGFR(3), GRB2(1), HRAS(4), JAK1(6), MAP2K4(4), MAP3K1(5), PIK3R1(2), PLCG1(1), PRKCA(2), RAF1(1), RASA1(1), SHC1(3), SOS1(4), STAT1(1), STAT3(6) 25950804 47 34 45 17 13 6 6 15 7 0 0.546 1.000 1.000 525 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(1), AGPAT2(1), AGPAT3(2), AGPAT4(2), AGPS(1), CDS1(3), CDS2(1), CHAT(4), CPT1B(2), DGKA(1), DGKB(3), DGKD(4), DGKE(1), DGKH(2), DGKQ(1), DGKZ(3), ETNK1(1), GNPAT(2), GPD2(1), LCAT(1), LGALS13(1), PCYT1A(1), PCYT1B(1), PISD(1), PLA2G2A(1), PLA2G4A(4), PLA2G5(1), PLA2G6(2), PLCB2(1), PLCG1(1), PLCG2(3), PPAP2A(1), PPAP2B(1) 36472163 56 34 56 27 14 9 7 14 12 0 0.890 1.000 1.000 526 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 33 ACTA1(1), CRK(1), DOCK1(4), GAB1(1), GRB2(1), HGF(3), HRAS(4), ITGA1(2), MAP4K1(2), MAPK1(1), MET(4), PAK1(1), PIK3R1(2), PTK2(3), PTPN11(1), PXN(1), RAF1(1), RAP1A(1), RASA1(1), SOS1(4), STAT3(6) 30175965 45 34 43 20 13 6 10 9 7 0 0.720 1.000 1.000 527 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGTR1(3), ATF2(3), CALM1(1), EGFR(3), GRB2(1), HRAS(4), MAP2K4(4), MAP3K1(5), MAPK1(1), MEF2A(1), MEF2C(3), MEF2D(1), PAK1(1), PRKCA(2), PTK2(3), RAC1(1), RAF1(1), SHC1(3), SOS1(4), SYT1(1) 24540134 46 33 44 20 19 7 6 10 4 0 0.644 1.000 1.000 528 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 21 ARHGAP5(4), DIAPH1(2), FYN(1), GSN(6), HRAS(4), ITGA1(2), MAPK1(1), MYLK(4), PFN1(1), PIK3R1(2), PTK2(3), PXN(1), RAF1(1), ROCK1(5), SHC1(3), TLN1(4) 25986139 44 33 41 19 13 6 8 9 8 0 0.804 1.000 1.000 529 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(1), CDC7(2), MCM10(1), MCM2(1), MCM3(4), MCM4(2), MCM5(1), MCM6(4), MCM7(1), NACA(3), PCNA(2), POLA2(1), POLD1(3), POLD2(1), POLD3(1), POLE(6), POLE2(1), RFC1(5), RFC3(3), RFC5(1), RPA1(2), RPA2(1), RPA4(2), RPS27A(2), UBB(1), UBC(1) 37310754 53 32 53 29 15 17 5 9 7 0 0.909 1.000 1.000 530 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(1), ACTN1(1), ACTN2(2), BCAR1(3), BCR(2), CAPN1(2), CAPNS1(2), CAV1(1), FYN(1), GRB2(1), HRAS(4), ITGA1(2), MAPK1(1), PPP1R12B(1), PTK2(3), PXN(1), RAF1(1), RAP1A(1), ROCK1(5), SHC1(3), SOS1(4), TLN1(4), VCL(1) 34680930 47 32 44 22 15 3 9 9 11 0 0.834 1.000 1.000 531 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 CALM1(1), CAMK2A(1), CAMK2D(2), F2(2), FYN(1), GNA11(1), GNAI1(2), GNB1(1), GNGT1(1), GRB2(1), HRAS(4), JAK2(1), MAPK1(1), MYLK(4), PLCG1(1), PRKCA(2), RAF1(1), SHC1(3), SOS1(4), STAT1(1), STAT3(6), SYT1(1) 30689085 42 31 40 24 17 4 7 10 4 0 0.939 1.000 1.000 532 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(2), ADCY3(2), ADCY9(5), ARF1(1), ATP6V0A1(3), ATP6V0A2(4), ATP6V0B(1), ATP6V0D2(1), ATP6V1A(3), ATP6V1C2(5), ATP6V1E2(1), ATP6V1F(1), ATP6V1H(1), GNAS(2), PLCG1(1), PLCG2(3), PRKCA(2), SEC61A1(1), SEC61A2(1) 27218153 40 31 40 19 11 5 4 13 7 0 0.823 1.000 1.000 533 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 33 AKT1(3), CBL(1), CFLAR(2), E2F1(3), GRB2(1), HRAS(4), IL2RB(1), IRS1(3), JAK1(6), JAK3(1), MAPK1(1), MYC(1), NMI(1), PIK3R1(2), PPIA(1), RAF1(1), SHC1(3), SOS1(4), STAT5B(2), SYK(2) 24917838 43 31 40 17 14 7 5 6 11 0 0.600 1.000 1.000 534 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CEBPB(1), GRB2(1), HRAS(4), IL6(1), IL6ST(7), JAK1(6), JAK2(1), JAK3(1), PTPN11(1), RAF1(1), SHC1(3), SOS1(4), STAT3(6) 17476763 37 31 35 14 8 8 6 6 9 0 0.619 1.000 1.000 535 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(1), AARS2(2), ABAT(1), ACY3(1), ADSL(1), ADSS(1), AGXT(1), AGXT2(2), ASPA(1), ASRGL1(1), CAD(9), CRAT(1), DARS2(1), DDO(1), DLAT(1), DLD(2), GAD1(2), GAD2(9), GOT1(2), GOT2(1), NARS2(1), PC(2), PDHA1(1), PDHA2(4) 27836936 49 30 48 18 16 11 4 7 11 0 0.423 1.000 1.000 536 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(1), ALDH4A1(2), ALDH5A1(1), CAD(9), CPS1(4), EPRS(4), GAD1(2), GAD2(9), GLUD1(2), GLUL(1), GOT1(2), GOT2(1), NADSYN1(1), PPAT(1), QARS(1) 24486420 41 29 41 21 16 5 4 8 8 0 0.900 1.000 1.000 537 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(2), CD3D(1), CD4(1), CREBBP(8), GNAS(2), GNB1(1), GNGT1(1), HLA-DRA(1), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), PTPRC(8), ZAP70(6) 16932795 38 28 38 19 12 6 4 15 1 0 0.888 1.000 1.000 538 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(2), CD3D(1), CD4(1), CREBBP(8), GNAS(2), GNB1(1), GNGT1(1), HLA-DRA(1), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), PTPRC(8), ZAP70(6) 16932795 38 28 38 19 12 6 4 15 1 0 0.888 1.000 1.000 539 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(1), ASRGL1(1), CA1(1), CA12(1), CA13(1), CA14(2), CA2(3), CA3(1), CA4(2), CA5A(1), CA6(1), CA8(4), CA9(2), CPS1(4), CTH(2), GLUD1(2), GLUD2(2), GLUL(1), HAL(2) 15661324 34 28 34 12 9 9 1 10 5 0 0.480 1.000 1.000 540 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 25 AKT1(3), AKT2(1), AKT3(1), GRB2(1), IARS(2), IL13RA1(1), IL4(1), IL4R(3), INPP5D(3), JAK1(6), JAK2(1), JAK3(1), PI3(1), PPP1R13B(3), SERPINA4(1), SHC1(3), SOS1(4), SOS2(1), STAT6(3), TYK2(2) 25532837 42 28 41 19 13 7 5 9 8 0 0.764 1.000 1.000 541 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 31 A1BG(1), AKT1(3), AKT2(1), AKT3(1), BTK(1), CDKN2A(1), DAPP1(1), GRB2(1), GSK3A(3), GSK3B(1), IARS(2), IGFBP1(1), INPP5D(3), PDK1(2), PPP1R13B(3), RPS6KA1(2), RPS6KA2(2), SHC1(3), SOS1(4), SOS2(1), TEC(1), YWHAB(1), YWHAQ(2), YWHAZ(1) 24381799 42 28 41 15 12 6 3 11 10 0 0.482 1.000 1.000 542 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 ACHE(1), CHAT(4), DBH(5), GAD1(2), GAD2(9), HDC(2), MAOA(2), PAH(1), PNMT(1), SLC18A3(1), TPH1(1) 10553679 29 26 29 13 14 4 2 5 4 0 0.620 1.000 1.000 543 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(3), F2(2), F2R(2), F3(1), F5(5), F7(2), FGA(5), FGB(2), FGG(1), PROC(3), PROS1(3), SERPINC1(2) 12120463 31 26 31 13 13 4 2 11 1 0 0.704 1.000 1.000 544 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(1), CAPN1(2), CAPN2(2), CAPNS1(2), EGF(3), EGFR(3), HRAS(4), ITGA1(2), MAPK1(1), MYLK(4), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), PTK2(3), PXN(1), TLN1(4) 23980892 39 26 37 21 11 3 6 15 4 0 0.942 1.000 1.000 545 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(3), AP2A1(1), ARF1(1), BTK(1), EEA1(4), GSK3A(3), GSK3B(1), LYN(2), PDPK1(1), PFKL(2), PFKM(3), PFKP(3), PLCG1(1), PRKCE(2), PRKCZ(3), RAC1(1), VAV2(3) 18420771 35 26 34 14 7 8 5 9 6 0 0.496 1.000 1.000 546 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(2), F2R(2), GNAI1(2), GNB1(1), GNGT1(1), HRAS(4), ITGA1(2), MAPK1(1), PLA2G4A(4), PLCB1(3), PRKCA(2), PTGS1(2), PTK2(3), RAF1(1), SYK(2), TBXAS1(2) 17978901 34 26 32 13 14 5 6 7 2 0 0.486 1.000 1.000 547 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 39 BTG1(1), CEBPB(1), CLOCK(1), CRY2(4), DNAJA1(1), EIF4G2(1), ETV6(1), GSTM3(1), GSTP1(1), HERPUD1(1), NCKAP1(1), NCOA4(3), NR1D2(2), PER1(4), PER2(4), PPP2CB(1), PSMA4(1), SF3A3(1), SUMO3(1), TOB1(1), TUBB3(1), UCP3(1), UGP2(1), VAPA(2), ZFR(4) 25944674 41 25 41 15 10 6 3 12 10 0 0.762 1.000 1.000 548 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(3), C5(3), C6(5), ICAM1(1), IL1A(1), IL6(1), ITGA4(3), ITGAL(5), ITGB2(2), SELP(4), SELPLG(2), TNF(1), VCAM1(2) 18290146 33 25 32 17 15 4 6 6 2 0 0.739 1.000 1.000 549 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(2), CALM1(1), CREB1(1), GNAI1(2), GNAS(2), GNB1(1), GNGT1(1), HRAS(4), NFATC1(2), NFATC2(2), NFATC3(1), NFATC4(1), PLCG1(1), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), PRKCA(2), RAF1(1), SYT1(1) 25614852 37 24 35 18 11 2 7 13 4 0 0.898 1.000 1.000 550 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH3B1(1), AOC2(3), AOC3(1), ASPA(1), CNDP1(3), HAL(2), HARS(1), HDC(2), MAOA(2), MAOB(2) 17915603 30 24 29 12 8 6 3 8 5 0 0.737 1.000 1.000 551 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ACY1(2), ALDH18A1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH7A1(2), AMD1(1), AOC2(3), AOC3(1), ARG1(1), ARG2(1), CPS1(4), MAOA(2), MAOB(2), NAGS(1), ODC1(1), OTC(1), SRM(1) 21566731 30 24 30 13 7 7 2 10 4 0 0.761 1.000 1.000 552 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(4), ARHGEF1(5), GNA13(2), GNB1(1), GNGT1(1), MYLK(4), PLCB1(3), PPP1R12B(1), PRKCA(2), ROCK1(5) 15254702 28 24 27 12 5 6 4 11 2 0 0.783 1.000 1.000 553 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(1), CDK7(2), ERCC3(1), GTF2E1(1), GTF2E2(1), GTF2H4(1), ILK(1), POLR1A(3), POLR1B(3), POLR2A(6), POLR2B(4), POLR2C(1), POLR2E(1), POLR3B(3), POLR3D(1), TAF13(1), TAF5(1), TAF6(1) 25804357 33 24 33 21 8 6 5 10 4 0 0.974 1.000 1.000 554 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(1), ABAT(1), ADSL(1), ADSS(1), AGXT(1), AGXT2(2), ASPA(1), CAD(9), CRAT(1), DDO(1), GAD1(2), GAD2(9), GOT1(2), GOT2(1), PC(2) 19191428 35 23 35 15 13 5 4 5 8 0 0.674 1.000 1.000 555 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(2), ACAA2(1), ADH1A(1), ADH1B(1), ADH4(1), ADH6(3), ADHFE1(1), AKR1C4(1), AKR1D1(1), ALDH1A1(2), ALDH1A2(4), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), CYP7A1(1), HADHB(1), SOAT2(3) 17111136 29 23 28 13 7 3 6 7 6 0 0.738 1.000 1.000 556 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 24 GH1(3), GHR(1), GRB2(1), HRAS(4), IRS1(3), JAK2(1), MAPK1(1), PIK3R1(2), PLCG1(1), PRKCA(2), RAF1(1), RPS6KA1(2), SHC1(3), SOS1(4), STAT5B(2) 22787669 31 23 29 12 12 5 5 4 5 0 0.561 1.000 1.000 557 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(3), GABBR1(1), GPRC5B(1), GPRC5C(1), GRM1(9), GRM2(2), GRM3(4), GRM4(2), GRM5(5), GRM7(2), GRM8(2) 15500182 32 23 31 14 19 2 2 4 5 0 0.511 1.000 1.000 558 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B4GALT5(1), GALNT10(5), GALNT11(2), GALNT12(2), GALNT13(1), GALNT14(3), GALNT2(1), GALNT3(5), GALNT4(1), GALNT8(2), GALNTL5(3), GCNT1(2), GCNT3(1), GCNT4(1), OGT(1), ST3GAL1(2), ST6GALNAC1(1), WBSCR17(2) 23806767 36 23 36 16 14 4 2 11 5 0 0.790 1.000 1.000 559 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 IFNB1(1), IKBKB(1), IL1A(1), IL1RAP(2), IL6(1), IRAK1(1), IRAK2(4), IRAK3(4), MAP2K3(1), MAP2K6(1), MAP3K1(5), MAP3K7(2), NFKB1(3), RELA(3), TGFB2(2), TNF(1), TRAF6(2) 21719886 35 23 35 16 13 8 3 5 6 0 0.683 1.000 1.000 560 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(1), CAMK2D(2), DAG1(2), ITPKB(2), ITPR1(4), ITPR2(8), ITPR3(6), NFAT5(1), PDE6B(2), PDE6C(1), PDE6D(1), SLC6A13(3), TF(1) 26309900 34 23 34 16 11 6 2 9 6 0 0.817 1.000 1.000 561 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(8), APOA4(2), APOC1(1), APOE(2), CETP(2), CYP7A1(1), DGAT1(1), HMGCR(1), LCAT(1), LDLR(3), LIPC(1), LPL(1), LRP1(12), SCARB1(2) 20196690 38 23 38 16 15 9 4 4 6 0 0.466 1.000 1.000 562 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(2), ACAA2(1), ADH1A(1), ADH1B(1), ADH4(1), ADH6(3), ADHFE1(1), AKR1C4(1), AKR1D1(1), ALDH1A3(2), ALDH1B1(2), ALDH2(1), ALDH3A1(1), ALDH7A1(2), CYP7A1(1), HADHB(1), RDH12(1), SLC27A5(2), SOAT2(3) 23223527 28 22 28 14 7 3 5 8 5 0 0.844 1.000 1.000 563 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 15 CREBBP(8), EP300(7), FYN(1), IL7(2), IL7R(1), JAK1(6), JAK3(1), NMI(1), PIK3R1(2), STAT5B(2) 18888567 31 22 31 15 6 6 3 9 7 0 0.901 1.000 1.000 564 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(1), EGF(3), EGFR(3), GRB2(1), HRAS(4), MAPK1(1), PTPRB(5), RAF1(1), RASA1(1), SHC1(3), SOS1(4), SPRY3(1) 18407053 28 22 26 12 10 2 4 9 3 0 0.770 1.000 1.000 565 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(2), CD38(1), ENPP1(3), ENPP3(2), NADK(1), NADSYN1(1), NMNAT1(1), NNMT(1), NNT(2), NT5C1B(2), NT5C2(3), NT5E(1), NT5M(1), NUDT12(3) 15883813 24 21 24 10 6 5 1 6 6 0 0.688 1.000 1.000 566 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(1), POLA2(1), POLD1(3), POLD2(1), POLD3(1), POLE(6), POLE2(1), POLG(2), POLG2(1), POLI(1), POLL(1), POLM(1), POLQ(6), PRIM2(2), REV1(2), REV3L(5), RFC5(1) 29843113 36 21 36 14 8 10 3 7 8 0 0.778 1.000 1.000 567 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 21 GRB2(1), HRAS(4), JAK2(1), PIK3R1(2), PLCG1(1), PRKCA(2), RAF1(1), RASA1(1), SHC1(3), SOS1(4), STAT1(1), STAT3(6), STAT5B(2), THPO(1) 20518367 30 21 28 11 10 5 5 5 5 0 0.491 1.000 1.000 568 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCL11(1), CCR3(1), CFL1(1), GNAS(2), GNB1(1), GNGT1(1), HRAS(4), LIMK1(2), MAPK1(1), PIK3C2G(1), PLCB1(3), PPP1R12B(1), PRKCA(2), PTK2(3), RAF1(1), ROCK2(1) 18407445 26 20 24 13 7 3 4 9 3 0 0.936 1.000 1.000 569 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QB(1), C1S(4), C2(1), C3(3), C5(3), C6(5), C8A(3), C8B(2), C9(3), MASP1(2) 15309765 27 20 27 12 11 2 3 5 6 0 0.695 1.000 1.000 570 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 22 ABL1(5), ATR(3), CCNA1(1), CDC25A(4), CDKN1A(2), CDKN2A(1), DHFR(2), E2F1(3), GSK3B(1), HDAC1(1), RB1(3), TFDP1(2), TGFB2(2) 16803197 30 20 30 12 8 4 6 1 10 1 0.731 1.000 1.000 571 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 GRB2(1), HRAS(4), IL2RB(1), JAK1(6), JAK3(1), RAF1(1), SHC1(3), SOS1(4), STAT5B(2), SYK(2) 16980318 25 20 23 16 8 4 5 2 6 0 0.917 1.000 1.000 572 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(1), ADCY1(2), GNAI1(2), GNAS(2), GNB1(1), GNGT1(1), HRAS(4), MAPK1(1), MYT1(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), RPS6KA1(2) 15085400 25 20 23 10 7 2 6 10 0 0 0.727 1.000 1.000 573 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CREBBP(8), EP300(7), HDAC3(2), IKBKB(1), NFKB1(3), RELA(3), RIPK1(1), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRAF6(2) 16426930 30 20 30 13 9 9 4 6 2 0 0.636 1.000 1.000 574 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BIRC2(1), CASP8(1), CFLAR(2), MAP2K4(4), MAP3K3(1), MAP3K7(2), NFKB1(3), NFKBIB(2), NFKBIE(1), NFKBIL1(1), RALBP1(1), RIPK1(1), TNF(1), TNFAIP3(1), TNFRSF1A(1), TNFRSF1B(1), TRAF2(5) 19984934 29 20 29 11 9 7 1 8 4 0 0.560 1.000 1.000 575 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QB(1), C1S(4), C2(1), C3(3), C5(3), C6(5), C8A(3), C9(3), MASP1(2), MASP2(2) 15673730 27 19 27 13 10 2 4 6 5 0 0.737 1.000 1.000 576 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 22 BCAR1(3), CRK(1), GNAI1(2), GNB1(1), GNGT1(1), HRAS(4), MAPK1(1), NFKB1(3), PIK3C2G(1), PIK3R1(2), PLCG1(1), PRKCA(2), PTK2(3), PXN(1), RAF1(1), RELA(3) 18581570 30 19 28 12 9 5 6 6 4 0 0.660 1.000 1.000 577 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(1), DLG4(3), EPHB2(4), F2(2), F2RL1(1), MAPK1(1), PLD1(3), PLD2(2), PTK2(3), RAF1(1), RASAL1(3), TEC(1), VAV1(3) 20176408 28 19 28 13 14 3 1 7 3 0 0.806 1.000 1.000 578 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD28(2), CD3D(1), CD8A(1), ICAM1(1), ITGAL(5), ITGB2(2), PTPRC(8) 7934954 21 19 20 10 8 3 3 5 2 0 0.634 1.000 1.000 579 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(1), AGTR1(3), CMA1(2), COL4A1(2), COL4A2(4), COL4A3(2), COL4A4(3), COL4A5(3), COL4A6(4) 18336944 24 18 24 11 6 6 1 6 5 0 0.806 1.000 1.000 580 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(3), EDNRA(1), EGF(3), EGFR(3), HRAS(4), MYC(1), NFKB1(3), PLCG1(1), PRKCA(2), RELA(3) 15140155 24 18 22 12 6 3 4 10 1 0 0.831 1.000 1.000 581 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(1), F13A1(4), F2(2), F2R(2), FGA(5), FGB(2), FGG(1), PLAT(3), PLG(1), SERPINB2(1) 9886796 22 18 22 18 11 2 1 8 0 0 0.993 1.000 1.000 582 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(2), IL22(1), IL22RA2(1), JAK1(6), JAK2(1), JAK3(1), STAT1(1), STAT3(6), STAT5B(2), TYK2(2) 13497691 23 18 23 10 1 5 3 8 6 0 0.752 1.000 1.000 583 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD28(2), CD3D(1), CD4(1), ICAM1(1), ITGAL(5), ITGB2(2), PTPRC(8) 8322645 21 18 20 10 8 3 3 6 1 0 0.670 1.000 1.000 584 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(2), GNAS(2), GNB1(1), GNGT1(1), PPP2CA(2), PRKAA2(5), PRKAG1(3), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1) 11280071 23 17 23 10 5 4 3 10 1 0 0.821 1.000 1.000 585 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(2), B4GALNT1(3), GLB1(2), HEXB(2), LCT(6), SLC33A1(1), ST3GAL1(2), ST6GALNAC3(1), ST6GALNAC4(2), ST8SIA1(1), ST8SIA5(1) 12179707 23 17 23 15 12 3 2 4 2 0 0.925 1.000 1.000 586 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(4), ACE2(1), AGTR1(3), ANPEP(2), CMA1(2), CPA3(1), CTSG(2), ENPEP(2), LNPEP(1), MAS1(1), MME(2), THOP1(2) 15576086 23 17 22 14 7 7 2 6 1 0 0.904 1.000 1.000 587 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 28 CREB1(1), EEF2K(5), EIF4E(1), GRB2(1), MAP3K8(1), MAPK1(1), MOS(1), NFKB1(3), RAP1A(1), RPS6KA1(2), RPS6KA2(2), SHC1(3), SOS1(4), SOS2(1) 20623532 27 17 27 11 12 7 2 3 3 0 0.471 1.000 1.000 588 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QB(1), C1S(4), C2(1), C3(3), C5(3), C6(5), C8A(3), C9(3) 12875060 23 16 23 11 9 2 3 4 5 0 0.726 1.000 1.000 589 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(2), CD2(1), IFNB1(1), IL10(1), IL12A(1), IL12B(1), IL4(1), ITGAX(3), TLR2(2), TLR4(2), TLR7(3), TLR9(1) 13743026 19 16 18 12 5 3 1 7 3 0 0.880 1.000 1.000 590 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 26 ACLY(2), ACO1(1), ACO2(1), CS(3), DLD(2), FH(3), IDH3A(1), IDH3B(1), MDH1(1), PC(2), PCK2(2), SDHA(3), SDHB(2), SDHC(2), SUCLA2(1) 21366053 27 16 27 14 4 6 5 5 7 0 0.790 1.000 1.000 591 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(4), DHCR24(2), DHCR7(1), EBP(1), GGCX(2), HMGCR(1), HSD17B7(2), IDI2(2), LSS(2), MVK(1), NQO1(2), SQLE(1), TM7SF2(1) 14064383 22 16 21 10 9 5 2 2 4 0 0.649 1.000 1.000 592 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 20 GRB2(1), HRAS(4), IRS1(3), PIK3R1(2), PTPN11(1), RAF1(1), RASA1(1), SHC1(3), SOS1(4) 17069484 20 16 18 10 10 1 4 1 4 0 0.808 1.000 1.000 593 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(1), CALM1(1), CAPN2(2), CAPNS1(2), EP300(7), HDAC1(1), HDAC2(1), MEF2D(1), NFATC1(2), NFATC2(2), PPP3CA(2), PPP3CB(1), PPP3CC(2), PRKCA(2), SYT1(1) 17964790 28 16 28 13 10 3 3 9 3 0 0.783 1.000 1.000 594 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 IKBKB(1), IL1A(1), IRAK1(1), MAP3K1(5), MAP3K7(2), NFKB1(3), RELA(3), RIPK1(1), TLR4(2), TNF(1), TNFAIP3(1), TNFRSF1A(1), TNFRSF1B(1), TRAF6(2) 17746240 25 16 25 12 9 7 2 3 4 0 0.678 1.000 1.000 595 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 IKBKB(1), MAP2K3(1), MAP2K4(4), MAP2K6(1), MAP3K1(5), MAP4K2(1), NFKB1(3), RELA(3), RIPK1(1), TANK(1), TNF(1), TNFRSF1A(1), TRAF2(5) 17605880 28 16 28 11 9 7 3 6 3 0 0.503 1.000 1.000 596 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(2), CREB1(1), CREBBP(8), EP300(7), NCOA3(1), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), RARA(1), RXRA(2) 15259656 29 15 29 13 10 4 6 8 1 0 0.687 1.000 1.000 597 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(1), GTF2E1(1), HDAC3(2), NCOA1(1), NCOA2(2), NCOA3(1), NCOR2(7), POLR2A(6), RARA(1), RXRA(2) 18282376 24 15 24 22 9 6 2 4 3 0 0.995 1.000 1.000 598 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(2), COL4A2(4), COL4A3(2), COL4A4(3), COL4A5(3), COL4A6(4), P4HB(1), SLC23A2(1), SLC2A1(1) 18189682 21 14 21 10 8 5 0 3 5 0 0.800 1.000 1.000 599 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(1), ACTN1(1), ACTN2(2), CAPN1(2), CAPNS1(2), ITGA1(2), PTK2(3), PXN(1), RAC1(1), SPTAN1(2), TLN1(4) 21023448 21 13 21 13 8 1 2 5 5 0 0.948 1.000 1.000 600 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 31 GTF2E1(1), GTF2E2(1), GTF2H3(2), GTF2H4(1), STON1(1), TAF1(2), TAF13(1), TAF2(1), TAF4(1), TAF5(1), TAF5L(3), TAF6(1), TAF7L(3) 23834473 19 12 19 14 6 4 4 4 1 0 0.980 1.000 1.000 601 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(1), BAIAP2(1), CASP1(2), CASP8(1), GAPDH(1), ITCH(2), MAGI1(2), MAGI2(2), RERE(3), WWP1(3), WWP2(1) 17695052 19 12 19 10 4 3 3 4 5 0 0.884 1.000 1.000 602 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(1), B3GNT7(2), B4GALT1(2), B4GALT2(2), B4GALT3(1), B4GALT4(1), CHST1(1), CHST2(1), CHST4(1), FUT8(2), ST3GAL1(2), ST3GAL3(1) 9169239 17 11 17 9 9 3 2 3 0 0 0.833 1.000 1.000 603 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 ICAM1(1), ITGA4(3), ITGAL(5), ITGB2(2), SELE(1) 8900916 12 11 11 7 6 0 3 3 0 0 0.811 1.000 1.000 604 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 EGR1(3), HRAS(4), KLK2(1), MAPK1(1), RAF1(1) 6045731 10 10 8 11 4 0 4 1 1 0 0.996 1.000 1.000 605 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(2), KHK(1), LCT(6), MPI(1), PYGL(4), PYGM(1) 9842043 15 10 14 10 9 2 0 3 1 0 0.883 1.000 1.000 606 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(2), GNAS(2), GNB1(1), GNGT1(1), PRKACA(2), PRKAR1A(2) 4843467 10 10 10 7 2 1 0 7 0 0 0.985 1.000 1.000 607 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(4), LPO(2), MPO(3), TPO(5) 6131553 14 10 14 6 8 2 0 4 0 0 0.597 1.000 1.000 608 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(4), CSF1(1), SPN(1), TGFB2(2), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TNFRSF8(3), TNFSF8(2) 9555858 16 10 16 10 6 4 3 2 1 0 0.831 1.000 1.000 609 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(1), GNAS(2), GNB1(1), GNGT1(1), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1), PRKCA(2) 7054909 14 9 14 8 4 1 1 8 0 0 0.937 1.000 1.000 610 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(2), CFTR(3), GNAS(2), PRKAR1A(2), PRKAR1B(4), PRKAR2A(1) 9596071 14 9 14 8 4 3 1 6 0 0 0.920 1.000 1.000 611 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 FOSB(1), GRIA2(5), JUND(2) 2756375 8 8 8 6 3 2 1 2 0 0 0.932 1.000 1.000 612 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 CASP8(1), RIPK1(1), TNF(1), TNFRSF1A(1), TNFRSF1B(1), TRAF2(5) 6108195 10 7 10 6 4 3 1 2 0 0 0.768 1.000 1.000 613 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM1(1), CCR5(2), PLCG1(1), PRKCA(2), SYT1(1) 10139044 7 6 7 5 4 1 0 2 0 0 0.873 1.000 1.000 614 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(2), EIF4E(1), LDHB(1), LDHC(1), NCL(1) 6599531 6 4 6 4 1 3 1 1 0 0 0.819 1.000 1.000 615 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(1) 533210 1 1 1 2 1 0 0 0 0 0 0.977 1.000 1.000 616 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 1268227 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000