Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.006 0.118 -9999.0 0.0 -0.509 21.0 21.0 IHH 0.036 0.075 0.217 29.0 -0.207 21.0 50.0 SHH Np/Cholesterol/GAS1 -0.023 0.082 0.159 3.0 -0.176 98.0 101.0 LRPAP1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.024 0.081 0.175 98.0 -0.117 1.0 99.0 SMO/beta Arrestin2 0.014 0.098 -9999.0 0.0 -0.333 22.0 22.0 SMO -0.002 0.089 -9999.0 0.0 -0.341 23.0 23.0 AKT1 -0.0 0.094 -9999.0 0.0 -0.391 13.0 13.0 ARRB2 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.018 0.052 -9999.0 0.0 -0.308 12.0 12.0 ADRBK1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.001 0.088 -9999.0 0.0 -0.337 23.0 23.0 STIL -0.011 0.096 0.193 28.0 -0.285 23.0 51.0 DHH N/PTCH2 0.037 0.035 -9999.0 0.0 -0.214 8.0 8.0 DHH N/PTCH1 0.02 0.079 -9999.0 0.0 -0.238 35.0 35.0 PIK3CA 0.023 0.027 -9999.0 0.0 -0.308 3.0 3.0 DHH 0.024 0.039 0.174 3.0 -0.308 6.0 9.0 PTHLH -0.007 0.153 -9999.0 0.0 -0.652 21.0 21.0 determination of left/right symmetry -0.001 0.088 -9999.0 0.0 -0.337 23.0 23.0 PIK3R1 0.022 0.031 -9999.0 0.0 -0.308 4.0 4.0 skeletal system development -0.006 0.152 -9999.0 0.0 -0.646 21.0 21.0 IHH N/Hhip 0.015 0.109 0.195 2.0 -0.27 55.0 57.0 DHH N/Hhip 0.014 0.079 -9999.0 0.0 -0.214 51.0 51.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.001 0.088 -9999.0 0.0 -0.337 23.0 23.0 pancreas development -0.003 0.097 0.173 3.0 -0.307 45.0 48.0 HHAT 0.021 0.04 -9999.0 0.0 -0.308 7.0 7.0 PI3K 0.031 0.034 -9999.0 0.0 -0.243 6.0 6.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.007 0.1 0.174 1.0 -0.308 48.0 49.0 somite specification -0.001 0.088 -9999.0 0.0 -0.337 23.0 23.0 SHH Np/Cholesterol/PTCH1 -0.009 0.089 0.182 3.0 -0.279 26.0 29.0 SHH Np/Cholesterol/PTCH2 -0.009 0.071 0.154 9.0 -0.165 71.0 80.0 SHH Np/Cholesterol/Megalin -0.02 0.082 0.142 11.0 -0.17 99.0 110.0 SHH -0.041 0.078 0.26 5.0 -0.217 69.0 74.0 catabolic process 0.007 0.081 -9999.0 0.0 -0.272 35.0 35.0 SMO/Vitamin D3 -0.012 0.096 0.219 4.0 -0.301 27.0 31.0 SHH Np/Cholesterol/Hhip -0.022 0.089 0.162 6.0 -0.191 92.0 98.0 LRP2 0.001 0.093 0.174 9.0 -0.308 39.0 48.0 receptor-mediated endocytosis -0.027 0.104 -9999.0 0.0 -0.323 30.0 30.0 SHH Np/Cholesterol/BOC -0.013 0.072 0.179 4.0 -0.165 78.0 82.0 SHH Np/Cholesterol/CDO -0.009 0.067 0.155 5.0 -0.161 70.0 75.0 mesenchymal cell differentiation 0.023 0.087 0.19 92.0 -0.142 3.0 95.0 mol:Vitamin D3 -0.004 0.1 0.194 30.0 -0.29 24.0 54.0 IHH N/PTCH2 0.037 0.066 0.201 3.0 -0.21 23.0 26.0 CDON 0.026 0.02 0.174 3.0 -0.308 1.0 4.0 IHH N/PTCH1 0.022 0.09 0.248 1.0 -0.274 35.0 36.0 Megalin/LRPAP1 0.019 0.071 -9999.0 0.0 -0.21 40.0 40.0 PTCH2 0.027 0.025 0.174 4.0 -0.308 2.0 6.0 SHH Np/Cholesterol -0.017 0.061 -9999.0 0.0 -0.159 72.0 72.0 PTCH1 0.007 0.082 -9999.0 0.0 -0.273 35.0 35.0 HHIP -0.003 0.097 0.174 3.0 -0.308 45.0 48.0