Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Ephrin A  reverse signaling	96.0	677.0	7.0	-0.049	-0.0	1000.0	-1000.0	-0.011	-1000.0
Angiopoietin receptor Tie2-mediated signaling	89.0	7910.0	88.0	-0.29	0.075	1000.0	-1000.0	-0.059	-1000.0
Signaling mediated by p38-alpha and p38-beta	87.0	3854.0	44.0	-0.154	0.027	1000.0	-1000.0	-0.015	-1000.0
Glypican 2 network	87.0	349.0	4.0	0.031	0.061	1000.0	-1000.0	0.021	-1000.0
Endothelins	75.0	7295.0	96.0	-0.194	0.028	1000.0	-1000.0	-0.041	-1000.0
Glucocorticoid receptor regulatory network	67.0	7713.0	114.0	-0.407	0.213	1000.0	-1000.0	-0.038	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	57.0	1940.0	34.0	-0.05	0.03	1000.0	-1000.0	-0.027	-1000.0
IL23-mediated signaling events	57.0	3435.0	60.0	-0.299	0.046	1000.0	-1000.0	-0.07	-1000.0
Reelin signaling pathway	55.0	3126.0	56.0	-0.095	0.07	1000.0	-1000.0	-0.022	-1000.0
Integrins in angiogenesis	49.0	4161.0	84.0	-0.099	0.083	1000.0	-1000.0	-0.024	-1000.0
Thromboxane A2 receptor signaling	48.0	5126.0	105.0	-0.116	0.037	1000.0	-1000.0	-0.034	-1000.0
EPHB forward signaling	47.0	4015.0	85.0	-0.075	0.094	1000.0	-1000.0	-0.044	-1000.0
Aurora B signaling	46.0	3112.0	67.0	-0.091	0.116	1000.0	-1000.0	-0.026	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	45.0	3576.0	78.0	-0.115	0.059	1000.0	-1000.0	-0.032	-1000.0
S1P5 pathway	42.0	724.0	17.0	-0.045	0.042	1000.0	-1000.0	-0.002	-1000.0
Ras signaling in the CD4+ TCR pathway	42.0	724.0	17.0	-0.081	0.041	1000.0	-1000.0	-0.011	-1000.0
HIF-1-alpha transcription factor network	40.0	3049.0	76.0	-0.073	0.07	1000.0	-1000.0	-0.046	-1000.0
Ephrin B reverse signaling	40.0	1924.0	48.0	-0.068	0.034	1000.0	-1000.0	-0.029	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	40.0	2736.0	68.0	-0.157	0.062	1000.0	-1000.0	-0.074	-1000.0
LPA receptor mediated events	39.0	4007.0	102.0	-0.057	0.1	1000.0	-1000.0	-0.058	-1000.0
Noncanonical Wnt signaling pathway	38.0	1010.0	26.0	-0.04	0.027	1000.0	-1000.0	-0.028	-1000.0
S1P1 pathway	37.0	1353.0	36.0	-0.192	0.026	1000.0	-1000.0	-0.027	-1000.0
IL6-mediated signaling events	37.0	2848.0	75.0	-0.164	0.032	1000.0	-1000.0	-0.05	-1000.0
Signaling events mediated by the Hedgehog family	36.0	1911.0	52.0	-0.041	0.037	1000.0	-1000.0	-0.022	-1000.0
p75(NTR)-mediated signaling	36.0	4566.0	125.0	-0.073	0.072	1000.0	-1000.0	-0.046	-1000.0
Osteopontin-mediated events	35.0	1364.0	38.0	-0.054	0.051	1000.0	-1000.0	-0.021	-1000.0
EPO signaling pathway	35.0	1978.0	55.0	-0.019	0.048	1000.0	-1000.0	-0.02	-1000.0
EGFR-dependent Endothelin signaling events	35.0	753.0	21.0	-0.029	0.045	1000.0	-1000.0	-0.028	-1000.0
amb2 Integrin signaling	34.0	2831.0	82.0	-0.113	0.1	1000.0	-1000.0	-0.026	-1000.0
Nongenotropic Androgen signaling	34.0	1791.0	52.0	-0.117	0.06	1000.0	-1000.0	-0.021	-1000.0
S1P4 pathway	34.0	857.0	25.0	-0.045	0.048	1000.0	-1000.0	-0.017	-1000.0
Wnt signaling	33.0	235.0	7.0	-0.03	0.027	1000.0	-1000.0	0.0	-1000.0
Syndecan-1-mediated signaling events	32.0	1098.0	34.0	-0.019	0.1	1000.0	-1000.0	-0.022	-1000.0
BMP receptor signaling	32.0	2633.0	81.0	-0.079	0.067	1000.0	-1000.0	-0.013	-1000.0
Calcium signaling in the CD4+ TCR pathway	32.0	1020.0	31.0	-0.088	0.032	1000.0	-1000.0	-0.039	-1000.0
JNK signaling in the CD4+ TCR pathway	31.0	530.0	17.0	-0.119	0.065	1000.0	-1000.0	-0.023	-1000.0
Signaling events regulated by Ret tyrosine kinase	31.0	2599.0	82.0	-0.03	0.044	1000.0	-1000.0	-0.03	-1000.0
Effects of Botulinum toxin	31.0	819.0	26.0	-0.027	0.05	1000.0	-1000.0	-0.01	-1000.0
Glypican 1 network	30.0	1458.0	48.0	-0.034	0.063	1000.0	-1000.0	-0.024	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	30.0	3703.0	120.0	-0.073	0.089	1000.0	-1000.0	-0.039	-1000.0
Fc-epsilon receptor I signaling in mast cells	28.0	2756.0	97.0	-0.067	0.04	1000.0	-1000.0	-0.037	-1000.0
PLK1 signaling events	28.0	2397.0	85.0	-0.026	0.081	1000.0	-1000.0	-0.025	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	28.0	1479.0	52.0	-0.046	0.068	1000.0	-1000.0	-0.022	-1000.0
TCR signaling in naïve CD8+ T cells	28.0	2653.0	93.0	-0.056	0.073	1000.0	-1000.0	-0.035	-1000.0
Arf6 signaling events	27.0	1720.0	62.0	-0.037	0.043	1000.0	-1000.0	-0.02	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	27.0	2364.0	85.0	-0.121	0.034	1000.0	-1000.0	-0.042	-1000.0
IL4-mediated signaling events	27.0	2475.0	91.0	-0.245	0.12	1000.0	-1000.0	-0.103	-1000.0
FOXM1 transcription factor network	27.0	1393.0	51.0	-0.095	0.067	1000.0	-1000.0	-0.111	-1000.0
IL12-mediated signaling events	25.0	2188.0	87.0	-0.174	0.065	1000.0	-1000.0	-0.056	-1000.0
Plasma membrane estrogen receptor signaling	25.0	2162.0	86.0	-0.13	0.055	1000.0	-1000.0	-0.031	-1000.0
Visual signal transduction: Cones	24.0	948.0	38.0	-0.041	0.042	1000.0	-1000.0	-0.021	-1000.0
Regulation of p38-alpha and p38-beta	24.0	1317.0	54.0	-0.098	0.06	1000.0	-1000.0	-0.033	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	24.0	3013.0	125.0	-0.06	0.051	1000.0	-1000.0	-0.026	-1000.0
Rapid glucocorticoid signaling	24.0	493.0	20.0	-0.054	0.033	1000.0	-1000.0	-0.013	-1000.0
Presenilin action in Notch and Wnt signaling	23.0	1406.0	61.0	-0.122	0.073	1000.0	-1000.0	-0.032	-1000.0
PDGFR-alpha signaling pathway	23.0	1020.0	44.0	-0.134	0.051	1000.0	-1000.0	-0.032	-1000.0
Canonical Wnt signaling pathway	23.0	1182.0	51.0	-0.122	0.117	1000.0	-1000.0	-0.039	-1000.0
ErbB2/ErbB3 signaling events	22.0	1469.0	65.0	-0.08	0.037	1000.0	-1000.0	-0.047	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	22.0	1211.0	54.0	-0.095	0.07	1000.0	-1000.0	-0.024	-1000.0
Syndecan-2-mediated signaling events	22.0	1518.0	69.0	-0.008	0.044	1000.0	-1000.0	-0.037	-1000.0
Aurora C signaling	22.0	157.0	7.0	0.0	0.067	1000.0	-1000.0	-0.008	-1000.0
FAS signaling pathway (CD95)	22.0	1048.0	47.0	-0.22	0.042	1000.0	-1000.0	-0.032	-1000.0
BARD1 signaling events	21.0	1202.0	57.0	-0.03	0.045	1000.0	-1000.0	-0.041	-1000.0
Signaling events mediated by PTP1B	21.0	1621.0	76.0	-0.139	0.096	1000.0	-1000.0	-0.029	-1000.0
BCR signaling pathway	21.0	2170.0	99.0	-0.109	0.064	1000.0	-1000.0	-0.053	-1000.0
Visual signal transduction: Rods	21.0	1111.0	52.0	-0.041	0.058	1000.0	-1000.0	-0.012	-1000.0
IL27-mediated signaling events	20.0	1035.0	51.0	-0.347	0.077	1000.0	-1000.0	-0.054	-1000.0
S1P3 pathway	20.0	843.0	42.0	-0.028	0.04	1000.0	-1000.0	-0.03	-1000.0
a4b1 and a4b7 Integrin signaling	19.0	95.0	5.0	0.015	0.034	1000.0	-1000.0	0.017	-1000.0
IL1-mediated signaling events	19.0	1190.0	62.0	-0.037	0.067	1000.0	-1000.0	-0.022	-1000.0
Ceramide signaling pathway	18.0	1394.0	76.0	-0.022	0.072	1000.0	-1000.0	-0.025	-1000.0
Syndecan-4-mediated signaling events	18.0	1242.0	67.0	-0.049	0.098	1000.0	-1000.0	-0.029	-1000.0
IGF1 pathway	18.0	1069.0	57.0	-0.017	0.059	1000.0	-1000.0	-0.02	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	18.0	613.0	33.0	-0.066	0.061	1000.0	-1000.0	-0.021	-1000.0
HIF-2-alpha transcription factor network	17.0	773.0	43.0	-0.048	0.049	1000.0	-1000.0	-0.035	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	17.0	1274.0	74.0	-0.142	0.052	1000.0	-1000.0	-0.047	-1000.0
Insulin Pathway	17.0	1307.0	74.0	-0.124	0.076	1000.0	-1000.0	-0.039	-1000.0
Caspase cascade in apoptosis	16.0	1234.0	74.0	-0.038	0.063	1000.0	-1000.0	-0.027	-1000.0
Regulation of nuclear SMAD2/3 signaling	16.0	2204.0	136.0	-0.07	0.152	1000.0	-1000.0	-0.03	-1000.0
Coregulation of Androgen receptor activity	16.0	1237.0	76.0	-0.015	0.068	1000.0	-1000.0	-0.027	-1000.0
ErbB4 signaling events	16.0	1115.0	69.0	-0.08	0.059	1000.0	-1000.0	-0.029	-1000.0
Nectin adhesion pathway	16.0	1050.0	63.0	-0.037	0.061	1000.0	-1000.0	-0.025	-1000.0
TCGA08_p53	16.0	118.0	7.0	-0.013	0.026	1000.0	-1000.0	-0.009	-1000.0
TCGA08_retinoblastoma	16.0	129.0	8.0	-0.01	0.058	1000.0	-1000.0	-0.002	-1000.0
VEGFR1 specific signals	16.0	943.0	56.0	-0.055	0.042	1000.0	-1000.0	-0.031	-1000.0
Sphingosine 1-phosphate (S1P) pathway	15.0	432.0	28.0	-0.026	0.051	1000.0	-1000.0	-0.021	-1000.0
Cellular roles of Anthrax toxin	15.0	599.0	39.0	-0.023	0.026	1000.0	-1000.0	-0.015	-1000.0
Hedgehog signaling events mediated by Gli proteins	15.0	977.0	65.0	-0.222	0.065	1000.0	-1000.0	-0.027	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	15.0	589.0	37.0	-0.02	0.063	1000.0	-1000.0	-0.021	-1000.0
ceramide signaling pathway	15.0	753.0	49.0	-0.0	0.038	1000.0	-1000.0	-0.039	-1000.0
IL2 signaling events mediated by PI3K	15.0	886.0	58.0	-0.037	0.07	1000.0	-1000.0	-0.027	-1000.0
Class I PI3K signaling events	15.0	1140.0	73.0	-0.042	0.063	1000.0	-1000.0	-0.025	-1000.0
Signaling events mediated by PRL	15.0	530.0	34.0	-0.037	0.046	1000.0	-1000.0	-0.033	-1000.0
Regulation of Androgen receptor activity	15.0	1073.0	70.0	-0.078	0.042	1000.0	-1000.0	-0.031	-1000.0
Aurora A signaling	14.0	880.0	60.0	-0.061	0.074	1000.0	-1000.0	-0.019	-1000.0
FOXA2 and FOXA3 transcription factor networks	14.0	644.0	46.0	-0.056	0.044	1000.0	-1000.0	-0.086	-1000.0
TCGA08_rtk_signaling	14.0	387.0	26.0	-0.013	0.048	1000.0	-1000.0	-0.011	-1000.0
mTOR signaling pathway	13.0	712.0	53.0	-0.139	0.05	1000.0	-1000.0	-0.019	-1000.0
Retinoic acid receptors-mediated signaling	13.0	789.0	58.0	-0.042	0.049	1000.0	-1000.0	-0.032	-1000.0
IL2 signaling events mediated by STAT5	13.0	300.0	22.0	-0.014	0.048	1000.0	-1000.0	-0.017	-1000.0
LPA4-mediated signaling events	11.0	139.0	12.0	-0.03	0.021	1000.0	-1000.0	-0.017	-1000.0
IFN-gamma pathway	11.0	812.0	68.0	-0.023	0.073	1000.0	-1000.0	-0.038	-1000.0
Signaling events mediated by HDAC Class III	11.0	444.0	40.0	-0.068	0.05	1000.0	-1000.0	-0.039	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	10.0	885.0	83.0	-0.047	0.049	1000.0	-1000.0	-0.022	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	10.0	466.0	45.0	-0.0	0.063	1000.0	-1000.0	-0.036	-1000.0
PDGFR-beta signaling pathway	10.0	1028.0	97.0	-0.101	0.07	1000.0	-1000.0	-0.042	-1000.0
Class I PI3K signaling events mediated by Akt	9.0	624.0	68.0	-0.033	0.05	1000.0	-1000.0	-0.022	-1000.0
Paxillin-dependent events mediated by a4b1	9.0	333.0	36.0	-0.046	0.048	1000.0	-1000.0	-0.025	-1000.0
Syndecan-3-mediated signaling events	9.0	345.0	35.0	-0.022	0.072	1000.0	-1000.0	-0.014	-1000.0
FoxO family signaling	8.0	556.0	64.0	-0.021	0.06	1000.0	-1000.0	-0.048	-1000.0
E-cadherin signaling in the nascent adherens junction	8.0	663.0	76.0	-0.019	0.056	1000.0	-1000.0	-0.039	-1000.0
Regulation of Telomerase	8.0	822.0	102.0	-0.025	0.058	1000.0	-1000.0	-0.026	-1000.0
E-cadherin signaling in keratinocytes	8.0	351.0	43.0	-0.016	0.046	1000.0	-1000.0	-0.017	-1000.0
Canonical NF-kappaB pathway	7.0	284.0	39.0	-0.004	0.056	1000.0	-1000.0	-0.021	-1000.0
Atypical NF-kappaB pathway	7.0	243.0	31.0	-0.01	0.031	1000.0	-1000.0	-0.022	-1000.0
p38 MAPK signaling pathway	7.0	349.0	44.0	-0.03	0.069	1000.0	-1000.0	-0.018	-1000.0
Signaling mediated by p38-gamma and p38-delta	5.0	83.0	15.0	-0.017	0.029	1000.0	-1000.0	-0.024	-1000.0
Class IB PI3K non-lipid kinase events	5.0	15.0	3.0	-0.028	0.028	1000.0	-1000.0	-0.021	-1000.0
Signaling events mediated by HDAC Class II	4.0	313.0	75.0	-0.028	0.065	1000.0	-1000.0	-0.024	-1000.0
PLK2 and PLK4 events	4.0	13.0	3.0	-0.013	0.027	1000.0	-1000.0	-0.023	-1000.0
Circadian rhythm pathway	4.0	101.0	22.0	-0.007	0.039	1000.0	-1000.0	-0.023	-1000.0
Insulin-mediated glucose transport	4.0	133.0	32.0	-0.013	0.046	1000.0	-1000.0	-0.021	-1000.0
TRAIL signaling pathway	4.0	216.0	48.0	-0.011	0.049	1000.0	-1000.0	-0.025	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	3.0	85.0	23.0	0.008	0.053	1000.0	-1000.0	-0.016	-1000.0
Signaling events mediated by HDAC Class I	2.0	309.0	104.0	-0.052	0.064	1000.0	-1000.0	-0.035	-1000.0
Arf6 trafficking events	2.0	210.0	71.0	-0.046	0.05	1000.0	-1000.0	-0.036	-1000.0
Arf1 pathway	2.0	119.0	54.0	-0.006	0.048	1000.0	-1000.0	-0.012	-1000.0
Arf6 downstream pathway	1.0	67.0	43.0	-0.053	0.054	1000.0	-1000.0	-0.032	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	11.0	27.0	-0.011	0.059	1000.0	-1000.0	-0.026	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	0.024	0.046	1000.0	-1000.0	0.018	-1000.0
Alternative NF-kappaB pathway	0.0	9.0	13.0	-0.0	0.07	1000.0	-1000.0	-0.0	-1000.0
Total	3178	186867	7203	-8.95824755006	7.56275236335	131000	-131000	-3.76163786975	-131000