Clinical Features CN_CNMF METHLYATION_CNMF RPPA_CNMF RPPA_CHIERARCHICAL MRNASEQ_CNMF MRNASEQ_CHIERARCHICAL MIRSEQ_CNMF MIRSEQ_CHIERARCHICAL MIRSEQ_MATURE_CNMF MIRSEQ_MATURE_CHIERARCHICAL nMutated (%) nWild-Type Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q TP53 85 (34%) 162 3e-04 0.00527 9.9999e-06 0.00085 0.0054699 0.0595 0.056709 0.284 0.00038 0.00587 0.00013 0.00316 0.0055199 0.0595 4e-05 0.0017 0.00031 0.00527 0.0061499 0.0615 RB1 24 (10%) 223 0.00024 0.0051 0.00261 0.0341 0.079549 0.323 0.38205 0.714 0.00051999 0.00737 0.0096399 0.0819 9.9999e-06 0.00085 5.9999e-05 0.0017 0.0067899 0.0641 4e-05 0.0017 ATRX 36 (15%) 211 5.9999e-05 0.0017 0.3606 0.703 0.059899 0.289 0.55498 0.858 0.3987 0.721 0.092619 0.328 0.24543 0.596 0.44444 0.767 0.43879 0.767 0.01415 0.1 NUMBL 8 (3%) 239 0.95681 1 0.24378 0.596 0.95277 1 0.082369 0.326 0.53101 0.842 0.28851 0.621 0.57786 0.862 0.27305 0.618 0.29701 0.631 0.12106 0.396 MSH3 7 (3%) 240 0.76636 1 0.66233 0.896 1 1 0.82543 1 0.88636 1 0.062969 0.289 0.75013 0.989 0.53974 0.842 0.49238 0.813 0.21472 0.564 LTBP3 5 (2%) 242 0.12995 0.408 0.49529 0.813 0.28419 0.619 0.87743 1 0.2188 0.564 0.16627 0.464 0.075079 0.319 0.18032 0.487 0.16929 0.464 0.090979 0.328 EOMES 5 (2%) 242 0.92375 1 1 1 0.8852 1 0.26779 0.618 1 1 1 1 0.2798 0.618 0.27101 0.618 0.83887 1 1 1 PTEN 7 (3%) 240 0.01893 0.12 0.33108 0.678 1 1 0.66801 0.896 0.13188 0.408 0.26945 0.618 0.21889 0.564 0.30493 0.64 0.57827 0.862 0.03893 0.221 KRTAP5-5 7 (3%) 240 1 1 0.01186 0.096 0.27966 0.618 0.01335 0.0987 0.062509 0.289 0.10018 0.341 0.098559 0.341 0.086199 0.328 0.079749 0.323 0.071369 0.316 CABLES1 3 (1%) 244 1 1 0.32756 0.678 0.33926 0.679 0.57129 0.862 0.16663 0.464 0.80002 1 0.61039 0.88 1 1 NA NA NA NA TRAF7 4 (2%) 243 0.90566 1 0.66942 0.896 0.67467 0.896 0.15187 0.445 0.37599 0.711 0.16571 0.464 1 1 1 1 0.01689 0.115 0.051069 0.263 LOR 6 (2%) 241 0.072419 0.316 0.13171 0.408 0.01913 0.12 0.03517 0.214 0.66337 0.896 0.45845 0.772 0.14348 0.436 0.15028 0.445 NA NA NA NA R3HDM1 4 (2%) 243 0.39655 0.721 0.66817 0.896 0.4483 0.767 0.41505 0.743 0.37643 0.711 0.23551 0.596 0.80358 1 0.36372 0.703 NA NA NA NA NF1 9 (4%) 238 0.090849 0.328 0.04441 0.236 0.25033 0.599 0.0055999 0.0595 0.088839 0.328 0.0079199 0.0709 1 1 0.87124 1 0.03705 0.217 0.01266 0.0978 COL4A3 4 (2%) 243 0.04249 0.233 0.52853 0.842 0.33929 0.679 0.62991 0.885 0.58708 0.868 0.57154 0.862 0.53279 0.842 0.38778 0.717 1 1 0.94197 1 MEGF9 3 (1%) 244 0.59358 0.87 0.62695 0.885 NA NA NA NA 0.79319 1 0.93181 1 0.80379 1 0.80659 1 0.53495 0.842 1 1 SCAP 3 (1%) 244 0.11524 0.384 0.78807 1 0.45142 0.767 0.34398 0.68 0.61322 0.88 0.61608 0.88 0.42565 0.754 0.24015 0.596 0.49707 0.813 0.67359 0.896