rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(2), ATM(5), ATR(4), CCNA1(1), CCND1(1), CDK4(1), CDKN1A(2), CDKN2A(1), RB1(24), TFDP1(1), TGFB1(1), TP53(90) 10950702 133 106 118 7 13 13 16 24 65 2 8.89e-08 <1.00e-15 <1.03e-13 2 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(5), CDC25B(1), CDK4(1), MYT1(2), RB1(24), TP53(90) 6350812 123 100 108 8 10 16 14 20 61 2 5.74e-06 <1.00e-15 <1.03e-13 3 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(5), ATR(4), CDC25B(1), CDKN1A(2), CDKN2D(1), CHEK2(2), EP300(2), MDM2(1), MYT1(2), PRKDC(5), RPS6KA1(1), TP53(90) 15759879 116 95 101 13 11 20 14 26 45 0 0.000443 <1.00e-15 <1.03e-13 4 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 ATM(5), PRKCA(1), PTK2(3), STAT1(2), TLN1(2), TP53(90) 10014396 103 90 88 6 11 14 14 21 43 0 4.56e-06 <1.00e-15 <1.03e-13 5 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 ATM(5), CDKN1A(2), HIC1(1), MDM2(1), TP53(90) 7574022 99 89 84 11 11 14 12 22 40 0 0.00120 <1.00e-15 <1.03e-13 6 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(5), ATR(4), CHEK2(2), TP53(90) 5754609 101 88 86 5 10 15 12 22 42 0 2.36e-05 <1.00e-15 <1.03e-13 7 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 IFNG(1), LIN7A(1), NFKB1(1), RB1(24), RELA(2), TNF(1), TNFRSF1A(1), TP53(90), USH1C(2) 6700890 123 100 108 6 14 15 12 20 60 2 2.30e-08 1.55e-15 1.23e-13 8 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 42 FAS(1), MAP2K4(2), MAPK10(2), MDM2(1), MYC(3), NFKB1(1), RELA(2), RIPK1(2), TNF(1), TNFRSF1A(1), TP53(90), TRAF2(2) 13731663 108 92 93 11 14 18 11 22 43 0 4.96e-05 1.78e-15 1.23e-13 9 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(5), ATR(4), BRCA2(2), CHEK2(2), FANCC(2), RAD17(1), RAD50(2), TP53(90) 15765036 108 94 93 7 10 17 12 24 44 1 3.06e-05 1.89e-15 1.23e-13 10 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(4), PML(1), RARA(1), RB1(24), SIRT1(1), TNF(1), TNFRSF1A(1), TP53(90) 6775135 123 98 108 5 14 13 11 20 63 2 7.17e-09 2.00e-15 1.23e-13 11 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(2), CDKN2A(1), MDM2(1), MYC(3), PIK3CA(6), PIK3R1(1), RAC1(1), RB1(24), TP53(90), TWIST1(1) 7284112 130 103 114 6 13 14 12 24 65 2 9.01e-09 3.22e-15 1.54e-13 12 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(1), CUL1(3), RB1(24), TFDP1(1) 3165827 29 28 29 1 2 0 2 1 22 2 0.00756 3.44e-15 1.54e-13 13 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 MYC(3), SP1(2), SP3(2), TP53(90) 2491106 97 89 82 3 11 14 11 20 41 0 5.13e-08 3.55e-15 1.54e-13 14 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 ATM(5), CCND1(1), CDK4(1), CDKN1A(2), MDM2(1), RB1(24), TP53(90) 6576060 124 102 109 6 12 13 14 22 61 2 2.85e-07 3.77e-15 1.54e-13 15 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 EGFR(2), IGF1R(1), MYC(3), PRKCA(1), RB1(24), TEP1(2), TERF1(2), TERT(1), TP53(90) 10215409 126 102 111 6 13 14 12 20 65 2 9.74e-09 3.77e-15 1.54e-13 16 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 65 ATM(5), ATR(4), BAI1(3), CCNB3(1), CCND1(1), CDK4(1), CDKN1A(2), CDKN2A(1), CHEK2(2), DDB2(1), FAS(1), GTSE1(1), IGF1(1), MDM2(1), PTEN(8), RRM2(1), THBS1(1), TP53(90), TSC2(4), ZMAT3(1) 24162394 130 103 115 10 15 18 15 33 49 0 1.23e-06 4.00e-15 1.54e-13 17 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CUL1(3), NEDD8(1), RB1(24), TFDP1(1) 3122551 29 28 29 1 2 0 1 1 23 2 0.00782 4.66e-15 1.69e-13 18 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 CCND1(1), CDK4(1), CDKN1A(2), CDKN2A(1), MDM2(1), TP53(90) 2995120 96 90 81 4 12 12 11 21 40 0 1.21e-07 5.33e-15 1.80e-13 19 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 EIF2S2(1), NFKB1(1), RELA(2), TP53(90) 3662604 94 88 79 4 12 14 10 19 39 0 1.06e-06 5.55e-15 1.80e-13 20 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 GAB1(1), MAP2K4(2), MAP2K5(1), MAP2K7(2), MAP3K11(1), MAP3K13(1), MAP3K5(4), MAP3K7(1), MAP3K9(2), MAPK10(2), MAPK7(1), PAPPA(6), TP53(90), TRAF6(2), ZAK(1) 18355819 117 94 102 11 13 21 15 27 41 0 1.60e-05 6.33e-15 1.95e-13 21 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 65 ATM(5), CCNA1(1), CCND1(1), CCNH(1), CDK4(1), CDKN1A(2), CDKN2A(1), CDKN2D(1), CREB3L3(1), E2F3(1), E2F4(2), E2F6(1), GBA2(3), MCM3(1), MCM4(1), MCM5(1), MCM7(1), MDM2(1), MYC(3), MYT1(2), NACA(2), POLE(5), RB1(24), RPA1(1), TFDP1(1), TFDP2(1), TNXB(6), TP53(90) 28261674 161 114 146 17 19 25 20 29 66 2 1.20e-06 6.88e-15 2.02e-13 22 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(2), ATM(5), CDKN1A(2), CHEK2(2), MDM2(1), NFKB1(1), RAD50(2), RBBP8(1), RELA(2), TP53(90) 10708078 108 94 93 9 13 19 12 23 41 0 6.50e-05 7.33e-15 2.05e-13 23 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 MAP2K2(1), MAP2K3(2), MAP2K6(2), MAPK1(1), NFKB1(1), PIK3CA(6), PIK3R1(1), RB1(24), RELA(2), SP1(2) 7186285 42 39 41 2 3 3 4 6 24 2 0.00282 8.55e-15 2.29e-13 24 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 RB1(24), SP1(2), SP3(2) 2310880 28 27 28 0 0 1 2 1 22 2 0.00771 1.08e-14 2.76e-13 25 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CUL1(3), RB1(24), TFDP1(1) 3079847 28 27 28 2 2 0 1 1 22 2 0.0358 1.27e-14 3.12e-13 26 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(1), CCND1(1), CCNH(1), CDK4(1), CDKN1A(2), CDKN2A(1), CDKN2D(1), RB1(24), TFDP1(1) 5896485 33 32 33 1 2 1 4 2 22 2 0.00293 2.63e-14 6.23e-13 27 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 CCND1(1), CDK4(1), CDKN1A(2), MAPK1(1), NFKB1(1), PAK1(1), PIK3CA(6), PIK3R1(1), RAC1(1), RB1(24), RELA(2), TFDP1(1) 7421357 42 40 41 3 4 3 4 5 24 2 0.00570 2.80e-13 6.38e-12 28 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 58 ALG2(1), BFAR(2), BTK(1), DEDD(1), EGFR(2), EPHB2(1), FAF1(1), IL1A(1), MAP2K4(2), MAP2K7(2), MAP3K5(4), MAPK1(1), MAPK10(2), MAPK8IP3(2), MET(4), NFAT5(4), NFKB1(1), NFKBIL1(1), PFN2(1), RIPK1(2), ROCK1(1), TP53(90), TPX2(1), TRAF2(2) 26982017 130 105 115 12 15 27 15 26 47 0 3.04e-06 3.11e-13 6.83e-12 29 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 67 BNIP3L(1), CASP4(2), FAS(1), HELLS(1), IRF2(1), IRF3(1), IRF5(1), IRF6(1), MAP2K4(2), MAPK10(2), MDM2(1), MYC(3), NFKB1(1), PLEKHG5(3), RELA(2), RIPK1(2), TNF(1), TNFRSF1A(1), TNFRSF21(3), TP53(90), TRAF2(2) 21128927 122 97 107 16 16 22 12 24 48 0 0.000229 5.55e-13 1.18e-11 30 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 82 AIFM1(1), ATM(5), CAPN1(1), CSF2RB(2), FAS(1), IL1A(1), IRAK2(1), IRAK3(2), NFKB1(1), NTRK1(3), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PPP3CC(2), PRKACA(2), PRKAR2B(1), RELA(2), RIPK1(2), TNF(1), TNFRSF10D(1), TNFRSF1A(1), TP53(90), TRAF2(2) 31055363 134 106 118 14 20 19 19 28 48 0 2.24e-05 1.49e-11 3.05e-10 31 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(2), ATM(5), BUB1B(1), CCNA1(1), CCNB3(1), CCNH(1), CDC25B(1), CDK4(1), CDKN1A(2), CDKN2A(1), CHEK2(2), DTX4(1), E2F3(1), E2F4(2), E2F6(1), EP300(2), ESPL1(2), HDAC3(1), HDAC5(1), HDAC6(2), MCM3(1), MCM4(1), MCM5(1), MCM7(1), MDM2(1), MPEG1(1), PRKDC(5), PTPRA(1), PTTG1(1), RB1(24), TFDP1(1), TGFB1(1), TP53(90) 40904430 160 115 145 20 17 23 20 30 68 2 3.12e-05 3.65e-07 7.24e-06 32 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 BAG4(1), LMNB1(1), MADD(1), MAP2K4(2), MAP3K7(1), PAK1(1), PRKDC(5), RB1(24), RIPK1(2), SPTAN1(3), TNF(1), TNFRSF1A(1), TRAF2(2) 14629503 45 41 45 4 3 5 6 1 28 2 0.00880 4.46e-06 8.58e-05 33 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 110 ABL1(2), ANAPC1(2), ANAPC2(2), ANAPC4(1), ANAPC5(1), ATM(5), ATR(4), BUB1B(1), CCNA1(1), CCNB3(1), CCND1(1), CCNH(1), CDC25B(1), CDK4(1), CDKN1A(2), CDKN2A(1), CDKN2D(1), CHEK2(2), CREBBP(4), CUL1(3), DBF4(2), E2F3(1), EP300(2), ESPL1(2), FZR1(2), MCM3(1), MCM4(1), MCM5(1), MCM7(1), MDM2(1), PRKDC(5), PTTG1(1), RB1(24), SMAD3(1), TFDP1(1), TGFB1(1), TP53(90), YWHAE(1) 50392264 175 122 160 21 19 26 20 33 75 2 1.74e-05 4.62e-06 8.63e-05 34 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 PIK3CA(6), PIK3R1(1), PLCB1(4), PLCG1(2), PRKCA(1), VAV1(3) 4737732 17 15 16 1 2 2 1 8 4 0 0.0650 0.000605 0.0110 35 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 FAF1(1), LMNB1(1), MAP2K4(2), MAP3K7(1), PAK1(1), PRKDC(5), RB1(24), RIPK2(1), SPTAN1(3) 15686920 39 38 39 6 1 3 4 2 27 2 0.165 0.00156 0.0275 36 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 BCAR1(1), MAPK1(1), PIK3CA(6), PIK3R1(1), PTEN(8), PTK2(3) 7122146 20 18 19 1 2 1 3 9 5 0 0.0623 0.00206 0.0352 37 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 AGT(1), AGTR1(1), AGTR2(1), COL4A1(5), COL4A2(2), COL4A3(6), COL4A4(4), COL4A5(3), COL4A6(4), REN(1) 9388634 28 22 27 1 0 11 5 4 8 0 0.00309 0.00253 0.0421 38 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(1), MAPK1(1), NFKB1(1), PIK3C2G(7), PIK3CA(6), PIK3R1(1), PLCG1(2), PRKCA(1), PTK2(3), PTK2B(2), RELA(2) 10391282 27 26 26 2 2 4 5 8 8 0 0.0288 0.00282 0.0457 39 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(2), TAT(2), TYR(2) 1674708 6 6 6 0 2 2 1 0 1 0 0.161 0.00446 0.0705 40 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(2), CYP2C9(2) 744539 4 4 4 1 1 1 2 0 0 0 0.595 0.00776 0.120 41 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 CISH(2), JAK1(1), JAK3(2), PIAS1(2), PTPRU(7), SOAT1(1) 5204455 15 14 15 2 3 2 4 4 2 0 0.187 0.00870 0.131 42 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 EIF2S2(1), IGF1(1), IGF1R(1), INPPL1(1), PIK3CA(6), PIK3R1(1), PTEN(8) 7336935 19 16 18 0 3 2 1 9 4 0 0.00969 0.00979 0.144 43 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 DPM2(1), NTRK1(3), PIK3CA(6), PIK3R1(1), PLCG1(2), PRKCA(1) 5714646 14 14 13 1 4 1 1 4 4 0 0.118 0.0131 0.187 44 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 F13A1(3), F2R(1), FGA(2), FGB(2), FGG(2), PLG(1) 4909993 11 11 11 1 1 2 4 3 1 0 0.211 0.0133 0.187 45 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 CISH(2), IFNG(1), JAK1(1), PTPRU(7), STAT1(2) 4237234 13 12 13 2 2 3 3 4 1 0 0.183 0.0187 0.256 46 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(1), GABRA2(2), GABRA4(1), GABRA5(2), GABRA6(2), PRKCE(2) 2956453 10 9 10 1 2 4 1 1 2 0 0.131 0.0209 0.280 47 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 MAPK1(1), PIK3CA(6), PIK3CD(1), PTEN(8), PTK2B(2) 7331988 18 16 17 2 2 2 1 7 6 0 0.226 0.0228 0.299 48 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRB(2), HMOX1(1), IL10RA(2), IL1A(1), JAK1(1), STAT1(2), STAT5A(1), TNF(1) 4484234 11 11 11 0 3 1 3 1 3 0 0.0300 0.0243 0.312 49 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(5), COL4A2(2), COL4A3(6), COL4A4(4), COL4A5(3), COL4A6(4) 9453930 24 19 23 1 0 11 4 3 6 0 0.00559 0.0252 0.317 50 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(1), ALPL(3), ALPP(1), FPGS(1), GGH(1) 2477157 7 7 7 1 1 2 3 0 1 0 0.282 0.0537 0.654 51 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(1), PLCG1(2), PRKCA(1), PTK2B(2) 2400809 6 6 6 0 0 2 0 1 3 0 0.146 0.0541 0.654 52 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 FUT1(3), FUT2(1), FUT9(3) 2247711 7 6 7 1 3 3 0 1 0 0 0.187 0.0609 0.721 53 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARSB(2), PAH(1), TAT(2), YARS(1), YARS2(2) 3195117 8 8 8 0 0 3 2 2 1 0 0.0960 0.0708 0.823 54 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(1), ENO2(2), PAH(1), TAT(2), YARS(1) 2986316 7 7 7 0 1 2 1 1 2 0 0.164 0.0821 0.936 55 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 CISH(2), IL6R(1), JAK1(1), JAK3(2), PTPRU(7) 5706554 13 12 13 2 3 2 4 4 0 0 0.202 0.0873 0.974 56 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 FUT1(3), FUT2(1), FUT5(1) 1879647 5 5 5 0 2 2 1 0 0 0 0.104 0.0895 0.974 57 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 NFKB1(1), PIK3CA(6), PIK3R1(1), RELA(2) 5191370 10 10 9 1 2 2 1 3 2 0 0.196 0.0902 0.974 58 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 23 APC(5), AXIN1(1), BTRC(1), CCND1(1), CREBBP(4), CTBP1(1), DVL1(2), MAP3K7(1), MYC(3), TLE1(1), WIF1(3) 10905200 23 19 23 1 9 5 1 1 7 0 0.00426 0.0933 0.991 59 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(1), LPL(2), RXRA(1), TNF(1) 2106899 5 5 5 1 2 0 2 0 1 0 0.468 0.0963 1.000 60 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(4), EP300(2), FYN(1), IL2RG(1), IL7R(1), JAK1(1), JAK3(2), LCK(1), NMI(1), PIK3CA(6), PIK3R1(1), PTK2B(2), STAT5A(1) 10265659 24 19 23 2 4 4 3 7 6 0 0.0354 0.106 1.000 61 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ARPC1B(1), PAK1(1), PDGFRA(1), PIK3CA(6), PIK3R1(1), RAC1(1) 4956892 11 10 10 0 2 1 2 4 2 0 0.0619 0.112 1.000 62 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(1), PLCB1(4), TUB(3) 2584336 8 7 8 2 1 3 1 3 0 0 0.431 0.112 1.000 63 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 17 CDKN1A(2), NFATC2(1), PLCG1(2), PPP3CC(2), PRKCA(1), SP1(2), SP3(2), SYT1(1) 7316446 13 13 13 1 1 2 3 3 4 0 0.202 0.119 1.000 64 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(2), CYP2E1(2), NR1I3(1), PTGS2(1) 1945899 6 5 6 1 1 0 2 2 1 0 0.451 0.131 1.000 65 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDPS(2), IDI1(1) 1221002 3 3 3 0 0 0 1 0 2 0 0.835 0.133 1.000 66 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(1), BDH2(2), HMGCS1(1), HMGCS2(1), OXCT2(1) 2660992 6 6 6 1 3 0 2 1 0 0 0.415 0.137 1.000 67 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 CBS(1), DNMT1(1), DNMT3A(3), DNMT3B(2), MARS(1), MARS2(1), MTFMT(1), MTR(1), TAT(2) 7691995 13 13 13 1 1 1 3 3 4 1 0.213 0.146 1.000 68 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(1), PLCB1(4), PRKCA(1), RELA(2) 3011889 8 7 8 2 1 4 0 2 1 0 0.410 0.157 1.000 69 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(1), GNAS(2), PRKACA(2) 2434127 5 5 5 1 2 0 0 3 0 0 0.584 0.159 1.000 70 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 FUT1(3), FUT2(1), FUT9(3), GLA(1) 3621632 8 7 8 0 3 3 0 1 1 0 0.0506 0.160 1.000 71 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 12 IGF1(1), IGF1R(1), PIK3CA(6), PIK3R1(1) 4808268 9 9 8 0 1 1 1 4 2 0 0.0943 0.165 1.000 72 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 CDKN1A(2), MAP2K2(1), NGFR(1), NTRK1(3), PIK3CA(6), PIK3CD(1) 6195961 14 13 13 2 7 0 1 4 2 0 0.224 0.165 1.000 73 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(4), FTCD(1), GART(1), MTFMT(1), MTHFD1(1), MTHFD1L(1), MTHFR(1), MTHFS(1), MTR(1) 7017922 12 11 12 1 2 1 5 2 2 0 0.234 0.174 1.000 74 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 TAT(2) 941384 2 2 2 0 0 1 0 0 1 0 0.617 0.178 1.000 75 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA2A(1), ADORA3(2), P2RY2(1), P2RY6(1) 2041614 5 5 5 0 0 1 2 2 0 0 0.217 0.184 1.000 76 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 FUT1(3), FUT2(1), FUT9(3), GLA(1) 3832560 8 7 8 1 3 3 0 1 1 0 0.160 0.185 1.000 77 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(2), ACO1(3), ACSS2(2), IDH1(2) 4847518 9 8 9 1 1 3 1 2 2 0 0.155 0.188 1.000 78 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(3), ANXA3(2), ANXA4(1), ANXA6(1), EDNRA(1), HSD11B1(1), PLA2G4A(1), PTGER2(2), PTGIR(1), PTGIS(1), PTGS2(1), SCGB1A1(1), TBXAS1(1) 7529885 17 13 17 1 2 6 2 3 4 0 0.0194 0.194 1.000 79 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG3(1), ATG5(1), BECN1(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA17(1), IFNA8(1), IFNG(1), PIK3R4(2), PRKAA2(4), ULK1(2), ULK2(2), ULK3(1) 7837138 20 16 20 2 2 10 4 3 1 0 0.0246 0.201 1.000 80 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 EIF4A2(2), EIF4G1(1), EIF4G3(3), IRS1(1), MAPK1(1), PABPC1(2), PIK3CA(6), PIK3R1(1), PRKCA(1), PTEN(8) 10318499 26 21 25 4 2 6 2 9 7 0 0.158 0.201 1.000 81 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 AGT(1), AGTR2(1), EDNRA(1), EGF(4), EGFR(2), MYC(3), NFKB1(1), PLCG1(2), PRKCA(1), RELA(2) 7401387 18 13 18 3 2 7 1 2 6 0 0.0982 0.205 1.000 82 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 DOCK1(2), GAB1(1), HGF(1), ITGA1(1), MAP2K2(1), MAP4K1(3), MAPK1(1), MET(4), PAK1(1), PIK3CA(6), PIK3R1(1), PTEN(8), PTK2(3), PTK2B(2), PTPN11(3), RAP1A(1), RASA1(2) 16776175 41 33 40 5 8 8 5 11 9 0 0.0135 0.210 1.000 83 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR2(2), ITPKA(1), PDE1A(2), PDE1B(2), PLCB1(4), PLCB2(1) 4034236 12 9 12 3 4 4 1 2 1 0 0.263 0.213 1.000 84 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 EIF4A2(2), EIF4G1(1), EIF4G3(3), PIK3CA(6), PIK3R1(1), PTEN(8), TSC1(1), TSC2(4) 10251974 26 22 25 4 3 4 1 11 7 0 0.182 0.217 1.000 85 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 BRAF(1), CAMP(1), CREBBP(4), EGR1(1), EGR2(1), FRS2(1), MAP1B(5), MAP2K4(2), MAP2K7(2), MAPK1(1), MAPK10(2), MAPK8IP3(2), NTRK1(3), PIK3C2G(7), PIK3CA(6), PIK3CD(1), PIK3R1(1), PTPN11(3), TH(1) 19129765 45 38 44 5 8 10 6 11 10 0 0.00551 0.219 1.000 86 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(3), CHAT(1), PDHA2(2) 2534330 6 6 6 0 3 1 1 0 1 0 0.0754 0.220 1.000 87 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDPS(2), IDI1(1) 1609985 3 3 3 0 0 0 1 0 2 0 0.839 0.232 1.000 88 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH4(2), ADH7(3) 2070772 5 4 5 1 1 1 0 1 2 0 0.568 0.232 1.000 89 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLD1(2), POLE(5), POLG(1), POLQ(6) 6116622 14 11 14 0 1 5 6 1 1 0 0.0135 0.233 1.000 90 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(1), MBTPS1(1), SCAP(4), SREBF1(2), SREBF2(1) 4462487 9 8 9 1 2 2 3 1 1 0 0.166 0.234 1.000 91 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 COASY(1), DPYD(6), ENPP3(2), PANK1(1), PANK3(1), PPCS(1) 5147210 12 10 12 1 0 5 2 2 3 0 0.0707 0.254 1.000 92 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 APC(5), AXIN1(1), CCND1(1), DVL1(2), LBP(1), NFKB1(1), PIK3CA(6), PIK3R1(1), RELA(2), TIRAP(1), TLR4(1) 11124226 22 18 21 2 6 4 3 3 6 0 0.0299 0.265 1.000 93 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 EGF(4), EGFR(2), JAK1(1), MAP2K4(2), PIK3CA(6), PIK3R1(1), PLCG1(2), PRKCA(1), RASA1(2), SRF(1), STAT1(2), STAT5A(1) 13794753 25 19 24 3 2 6 3 5 8 1 0.0427 0.271 1.000 94 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(1), ITGAV(3), MAPK1(1), PDGFRA(1), PIK3CA(6), PIK3R1(1), PLCB1(4), PRKCA(1), PTK2(3), RAC1(1), SMPD2(1) 9961839 23 18 22 3 3 3 4 8 5 0 0.0900 0.275 1.000 95 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(2), MPO(4), TPO(1), TYR(2) 3588374 9 8 9 2 0 6 1 0 2 0 0.158 0.294 1.000 96 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 FUT1(3), FUT2(1) 2605915 4 4 4 0 2 2 0 0 0 0 0.162 0.301 1.000 97 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3G(1) 413486 1 1 1 0 0 0 1 0 0 0 0.840 0.306 1.000 98 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 CBS(1), DNMT1(1), DNMT3A(3), DNMT3B(2), MARS(1), MARS2(1), MTR(1) 6495443 10 10 10 1 1 0 2 3 3 1 0.349 0.311 1.000 99 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(1), IFNG(1), IL16(1), IL1A(1), TNF(1) 3603458 5 5 5 0 1 0 1 2 1 0 0.210 0.312 1.000 100 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 RAB27A(1), RAB4A(1), RAB6A(1) 1552071 3 3 3 0 1 1 0 0 1 0 0.332 0.313 1.000 101 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CCL3(1), EPO(1), IGF1(1), IL1A(1), TGFB1(1) 3095050 5 5 5 1 1 1 3 0 0 0 0.457 0.318 1.000 102 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(4), GART(1), MTHFD1(1), MTHFD1L(1), MTHFR(1), MTHFS(1), MTR(1) 6585096 10 9 10 1 2 0 4 2 2 0 0.366 0.325 1.000 103 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ANXA1(3), GNAS(2), NFKB1(1), NOS3(2), PIK3CA(6), PIK3R1(1), RELA(2), SYT1(1) 6717958 18 18 17 4 4 3 2 5 4 0 0.339 0.328 1.000 104 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 KLRC3(1), PAK1(1), PIK3CA(6), PIK3R1(1), PTK2B(2), RAC1(1), SYK(1), VAV1(3) 6984587 16 15 15 3 3 3 2 5 3 0 0.211 0.333 1.000 105 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP6(1), ENPP3(2), FLAD1(2), LHPP(2), TYR(2) 5531371 9 9 9 2 1 1 5 0 2 0 0.530 0.353 1.000 106 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(1), CCND1(1), CDK4(1), CDKN2A(1), E2F4(2) 3297441 6 5 6 0 1 0 2 2 1 0 0.176 0.354 1.000 107 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 CBS(1), MUT(2) 1799802 3 3 3 1 0 1 0 2 0 0 0.678 0.360 1.000 108 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(2), ENO1(1), PFKL(2), PKLR(2) 3451942 7 6 7 1 3 0 0 1 3 0 0.264 0.362 1.000 109 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 HLA-DRB1(1) 854069 1 1 1 1 1 0 0 0 0 0 0.868 0.372 1.000 110 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 16 ALOX12(2), ALOX15(1), ALOX15B(1), ALOX5(1), DPEP1(2), GGT1(1), PTGIS(1), PTGS2(1), TBXAS1(1) 5850401 11 11 11 2 2 2 4 2 1 0 0.263 0.372 1.000 111 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 CRY1(2), CRY2(1), PER1(3) 3079018 6 6 6 0 0 3 1 2 0 0 0.133 0.375 1.000 112 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 GNS(1), GUSB(2), HPSE2(3), IDUA(2), LCT(4), NAGLU(1), SPAM1(2) 7747223 15 14 15 2 5 3 4 1 2 0 0.0685 0.375 1.000 113 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(2), GABRA1(1), GABRA2(2), GABRA4(1), GABRA5(2), GABRA6(2) 4499992 10 9 10 2 2 4 1 2 1 0 0.255 0.376 1.000 114 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(1), ARHGEF1(1), F2R(1), MAP3K7(1), PIK3CA(6), PIK3R1(1), PLCB1(4), PPP1R12B(1), PRKCA(1), PTK2B(2), ROCK1(1) 9527472 20 18 19 4 2 4 3 6 5 0 0.265 0.382 1.000 115 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD86(1), HLA-DRB1(1), IFNG(1), IL12RB1(1), IL12RB2(3), IL18R1(1) 4646531 8 8 8 2 1 2 2 1 2 0 0.452 0.386 1.000 116 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(1), LPL(2) 1948237 3 3 3 0 1 0 1 1 0 0 0.409 0.397 1.000 117 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 FMOD(2) 1306624 2 2 2 0 1 1 0 0 0 0 0.382 0.402 1.000 118 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 25 MAP2K3(2), MAP2K4(2), MAP2K6(2), NFKB1(1), RELA(2), RIPK1(2), TNF(1), TNFRSF1A(1), TRAF2(2) 9024807 15 15 15 2 3 4 2 4 2 0 0.107 0.403 1.000 119 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(1), DIAPH1(2), FYN(1), ITGA1(1), MAPK1(1), MYLK(3), PIK3CA(6), PIK3R1(1), PTK2(3), ROCK1(1), TLN1(2) 13798973 22 18 21 2 3 2 6 6 5 0 0.0988 0.419 1.000 120 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(1), RIPK1(2), TNF(1), TNFRSF1A(1), TRAF2(2) 3057882 7 7 7 2 2 2 2 0 1 0 0.556 0.426 1.000 121 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 BCR(2), MAP2K4(2), MYC(3), PIK3CA(6), PIK3R1(1), STAT1(2), STAT5A(1) 10361922 17 16 16 2 3 2 3 4 5 0 0.0946 0.428 1.000 122 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(1), JAK1(1), STAT1(2) 3016983 4 4 4 0 0 1 1 1 1 0 0.300 0.436 1.000 123 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AASDHPPT(1), AASS(1) 1735243 2 2 2 0 0 1 0 0 1 0 0.595 0.438 1.000 124 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 IFNG(1) 1098253 1 1 1 0 0 0 0 1 0 0 0.799 0.446 1.000 125 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 GNS(1), GUSB(2), IDUA(2), LCT(4), NAGLU(1) 5409426 10 10 10 2 3 2 3 1 1 0 0.234 0.447 1.000 126 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 KHK(1), LCT(4), PGM1(1), PYGM(2) 5056127 8 8 8 1 1 4 3 0 0 0 0.133 0.455 1.000 127 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ3(1), NDUFA13(1) 1595328 2 2 2 1 0 1 1 0 0 0 0.813 0.458 1.000 128 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 IFNAR1(1), NFKB1(1), RELA(2), TRAF6(2) 4066113 6 6 6 1 1 2 2 1 0 0 0.386 0.459 1.000 129 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAS1(1), ALAS2(2), PPOX(1) 2780189 4 4 4 0 0 0 3 0 1 0 0.344 0.460 1.000 130 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(1), GAD1(1), HDC(3), TH(1) 2222450 6 6 6 2 2 3 0 1 0 0 0.448 0.468 1.000 131 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 PLCG1(2), PRKCA(1), PTK2B(2), SYT1(1) 5016544 6 6 6 1 0 2 0 1 3 0 0.374 0.472 1.000 132 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(2), TPK1(1) 2310105 3 3 3 0 1 0 1 0 1 0 0.399 0.478 1.000 133 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 DPM2(1), EGR1(1), MAP2K2(1), MAPK1(1), NGFR(1) 3125415 5 5 5 1 2 1 0 1 1 0 0.424 0.491 1.000 134 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(2), EIF2AK4(2), EIF2S2(1) 4196660 5 5 5 0 2 0 2 0 1 0 0.389 0.495 1.000 135 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 CHST11(1), SULT1A1(1), SULT1E1(1), SULT2A1(1), SUOX(1) 3389370 5 5 5 1 1 1 0 2 1 0 0.554 0.495 1.000 136 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP2(3), RANGAP1(2) 3142102 5 4 5 1 1 1 0 2 1 0 0.588 0.498 1.000 137 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(1), BCAR1(1), CTNNA1(2), CTNNA2(5), PTK2(3) 7199282 12 10 12 1 3 3 2 4 0 0 0.0991 0.509 1.000 138 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ENPP3(2), FLAD1(2), TYR(2) 3599910 6 6 6 2 0 1 3 0 2 0 0.717 0.509 1.000 139 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(1), MAP2K2(1), MAP2K3(2), MAP2K4(2), MAPK1(1), PAK1(1), PLCG1(2), PRKCA(1), PTK2B(2), RAC1(1), SYT1(1) 10558749 15 15 15 2 1 3 2 4 5 0 0.155 0.509 1.000 140 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 DPM2(1), NGFR(1), PIK3CA(6), PIK3R1(1), PLCG1(2) 7022078 11 11 10 2 2 1 1 4 3 0 0.328 0.511 1.000 141 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 APC(5), AR(4), BRAF(1), CAMP(1), CCL15(1), EGFR(2), GNA11(1), ITPKA(1), ITPR1(4), ITPR2(6), ITPR3(2), KCNJ3(1), KCNJ5(2), MAPK1(1), MAPK10(2), PHKA2(2), PIK3CA(6), PIK3CD(1), PIK3R1(1) 19698978 44 35 42 7 9 9 4 11 11 0 0.0261 0.515 1.000 142 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 SULT1E1(1), SULT2A1(1), SUOX(1) 2162512 3 3 3 0 0 1 0 1 1 0 0.427 0.517 1.000 143 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(1), CSF2RB(2), IGF1(1), IGF1R(1), KIT(4), PIK3CA(6), PIK3R1(1), PRKAR2B(1) 8095360 17 14 16 3 3 2 3 5 3 1 0.254 0.522 1.000 144 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 NFKB1(1), NOX1(1), RELA(2), TNF(1) 3683965 5 5 5 1 2 3 0 0 0 0 0.327 0.531 1.000 145 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(3), IDH1(2) 3265368 5 4 5 0 1 2 1 0 1 0 0.152 0.533 1.000 146 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD3G(1), IFNG(1), TGFB1(1), TGFBR1(1), TGFBR2(1), TGFBR3(2) 3822364 7 7 7 2 0 1 3 2 1 0 0.661 0.551 1.000 147 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CSF1R(2), EGF(4), EGFR(2), MET(4), PDGFRA(1), PRKCA(1), SH3GLB1(1), SH3GLB2(1) 7154050 16 10 16 2 2 7 2 2 3 0 0.0606 0.563 1.000 148 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(5), COL4A2(2), COL4A3(6), COL4A4(4), COL4A5(3), COL4A6(4), F11(1), F12(1), F2R(1), F5(5), F8(3), FGA(2), FGB(2), FGG(2), KLKB1(2), PROS1(1) 16302896 44 32 43 9 2 18 8 8 8 0 0.0982 0.568 1.000 149 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ARPC1B(1), NCKAP1(2), NTRK1(3), RAC1(1), WASF3(2) 5674758 9 8 9 1 5 2 0 0 2 0 0.211 0.570 1.000 150 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(3), DNMT1(1), MTNR1A(1), PTAFR(1), PTGER2(2), PTGIR(1) 4104026 9 7 9 2 2 0 3 2 2 0 0.422 0.578 1.000 151 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(1), AGT(1), AGTR1(1), AGTR2(1), KNG1(1), NOS3(2), REN(1) 3618924 8 7 8 2 0 1 2 1 4 0 0.634 0.580 1.000 152 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(3), GRHPR(1), MTHFD1(1), MTHFD1L(1) 4665657 6 5 6 1 0 2 2 0 2 0 0.443 0.583 1.000 153 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 GPD2(1), SDHA(1), UQCRC1(1) 2393603 3 3 3 0 1 0 1 1 0 0 0.459 0.584 1.000 154 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 JAK1(1), MAP2K4(2), PDGFRA(1), PIK3CA(6), PIK3R1(1), PLCG1(2), PRKCA(1), RASA1(2), SRF(1), STAT1(2), STAT5A(1) 12892303 20 18 19 3 2 3 2 6 6 1 0.146 0.589 1.000 155 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH4(2), ADH7(3), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1) 4906155 10 9 10 3 1 1 3 2 3 0 0.670 0.590 1.000 156 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD3G(1), CD86(1), CTLA4(1), HLA-DRB1(1), LCK(1), PIK3CA(6), PIK3R1(1), PTPN11(3) 4655719 15 13 14 4 3 3 3 4 2 0 0.412 0.594 1.000 157 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 CBS(1), GGT1(1), MARS(1), MARS2(1), SEPHS1(1) 4593312 5 5 5 0 1 0 3 1 0 0 0.278 0.601 1.000 158 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 MST1R(2), TNF(1) 2404936 3 3 3 1 2 0 0 1 0 0 0.649 0.603 1.000 159 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD34(1), CD3G(1), CD58(1) 2305245 3 3 3 0 0 2 1 0 0 0 0.311 0.606 1.000 160 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDOB(2) 1389491 2 2 2 1 1 0 0 0 1 0 0.806 0.615 1.000 161 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 CANX(1), CIITA(3), HLA-DOA(1), HLA-DOB(1), HLA-DQA2(2), HLA-DRB1(1), HLA-DRB5(1), HLA-E(1), HLA-F(1), HSP90AA1(2), HSP90AB1(2), IFNA1(1), IFNA14(1), IFNA16(1), IFNA17(1), IFNA8(1), KIR3DL1(2), KIR3DL2(1), KLRC3(1), LGMN(1) 17185098 26 23 26 3 5 7 7 5 2 0 0.0153 0.623 1.000 162 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 NRF1(1), UBE2C(1), UBE2G2(1), UBE2I(1), UBE2J1(1), UBE3A(1) 3942238 6 6 6 2 0 2 2 1 1 0 0.773 0.625 1.000 163 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAS1(1), ALAS2(2), BLVRB(2), COX10(1), CP(3), EARS2(1), EPRS(1), FTMT(2), GUSB(2), HCCS(1), HMOX1(1), HMOX2(1), PPOX(1), UGT1A10(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT2A3(1), UGT2B11(3), UGT2B15(1), UGT2B17(2) 15372800 31 25 31 5 7 5 9 4 6 0 0.122 0.631 1.000 164 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 50 CPT1B(1), CREBBP(4), EP300(2), HSD17B4(1), LPL(2), MAPK1(1), ME1(1), MYC(3), NCOA1(1), NCOR1(1), NCOR2(3), NRIP1(3), PIK3CA(6), PIK3R1(1), PPARA(1), PRKAR2B(1), PRKCA(1), PTGS2(1), RB1(24), RELA(2), RXRA(1), SP1(2), STAT5A(1), TNF(1) 23141515 65 52 64 12 8 8 7 9 31 2 0.0863 0.632 1.000 165 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 PIK3CA(6), PIK3R1(1), PLCG1(2), PRKCA(1), RASA1(2), STAT1(2), STAT5A(1) 10997162 15 14 14 2 2 3 1 4 5 0 0.160 0.635 1.000 166 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(1), C1QB(1), C1S(1), C3(4), C5(2), C6(4), C7(1), C8A(1), C9(3), MASP1(3), MASP2(1), MBL2(1) 7954958 23 19 23 5 3 6 5 6 3 0 0.181 0.636 1.000 167 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 AOC3(1), CES1(1) 2218652 2 2 2 1 2 0 0 0 0 0 0.733 0.636 1.000 168 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1) 2900271 5 5 5 2 0 0 2 2 1 0 0.820 0.637 1.000 169 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1) 2900271 5 5 5 2 0 0 2 2 1 0 0.820 0.637 1.000 170 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(1), CD33(1), IFNA1(1), IFNG(1), TLR2(3), TLR4(1), TLR9(2) 6694155 10 10 10 2 1 2 2 5 0 0 0.390 0.642 1.000 171 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CAMK2B(1), CAMK2G(1), CAMKK1(2), SYT1(1) 4301453 5 5 5 1 0 1 3 0 1 0 0.453 0.647 1.000 172 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(1), ACAT1(1) 2015575 2 2 2 0 0 0 1 1 0 0 0.646 0.651 1.000 173 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AASDHPPT(1), AASS(1) 2542768 2 2 2 0 0 1 0 0 1 0 0.607 0.653 1.000 174 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CD3G(1) 1153222 1 1 1 0 0 0 1 0 0 0 0.811 0.669 1.000 175 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 PRKCA(1), TGM2(1) 1867407 2 2 2 1 1 0 0 0 1 0 0.844 0.670 1.000 176 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(1), NME2(1), POLD1(2), POLG(1) 4819086 5 5 5 1 0 2 3 0 0 0 0.467 0.684 1.000 177 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(5), EGF(4), EGFR(2), TF(1) 4696072 12 7 12 4 1 5 2 1 3 0 0.474 0.684 1.000 178 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 NR1H4(1), RXRA(1) 1996186 2 2 2 1 0 0 1 0 1 0 0.867 0.687 1.000 179 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(2) 1768149 2 2 2 0 0 2 0 0 0 0 0.406 0.688 1.000 180 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ANGPTL2(2), ITGA9(1), ITPKA(1), ITPR1(4), ITPR2(6), ITPR3(2), MAPK1(1), NR1I3(1), PAK1(1), PDE3A(1), PDE3B(3), PI3(1), PIK3C2G(7), PIK3CA(6), PIK3CD(1), PIK3R1(1), VASP(1) 18020440 40 33 39 7 7 3 7 14 9 0 0.142 0.699 1.000 181 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 CALCR(3), CALCRL(1), CD97(1), CRHR2(4), ELTD1(3), EMR1(3), EMR2(2), GLP1R(2), GLP2R(2), GPR64(1), LPHN1(1), LPHN2(4), LPHN3(1), SCTR(3), VIPR1(2) 10142506 33 24 33 8 4 7 8 9 5 0 0.184 0.701 1.000 182 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP5O(1), ATP6AP1(2), ATP6V0A4(1), ATP6V1A(2), ATP6V1E1(1), FDXR(1) 5891919 8 7 8 2 1 0 4 2 1 0 0.609 0.701 1.000 183 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAS1(1), ALAS2(2) 3042020 3 3 3 1 0 0 2 0 1 0 0.754 0.704 1.000 184 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 22 IL1A(1), MAP3K7(1), NFKB1(1), RELA(2), RIPK1(2), TLR4(1), TNF(1), TNFRSF1A(1), TRAF6(2) 8984814 12 12 12 2 3 4 4 1 0 0 0.225 0.708 1.000 185 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(1), AGT(1), AGTR1(1), AGTR2(1), ANPEP(1), CTSG(1), LNPEP(2), MME(2), REN(1) 7677413 11 10 11 2 2 1 2 3 3 0 0.468 0.709 1.000 186 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3G(1), FYN(1), HLA-DRB1(1), LCK(1), PTPRC(4), ZAP70(5) 3349671 13 11 13 4 4 5 3 1 0 0 0.332 0.714 1.000 187 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 EPX(2), MPO(4), MTHFR(1), TPO(1) 4251294 8 7 8 2 0 5 1 0 2 0 0.202 0.716 1.000 188 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 B3GNT2(2), FUT1(3), FUT2(1), FUT5(1), FUT9(3) 5775991 10 9 10 2 3 5 1 1 0 0 0.194 0.721 1.000 189 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD3G(1), ITGB2(1), PTPRC(4) 3866326 6 6 6 2 2 1 3 0 0 0 0.611 0.722 1.000 190 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A2(1) 1398279 1 1 1 0 0 0 0 1 0 0 0.795 0.725 1.000 191 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(1), LDHB(1) 2492161 2 2 2 0 0 0 0 1 1 0 0.795 0.728 1.000 192 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 IFNG(1), IL1A(1), NR4A3(1) 3983156 3 3 3 1 1 0 1 1 0 0 0.709 0.731 1.000 193 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT2(2), CHST1(2), CHST4(1), FUT8(1) 4385616 6 5 6 0 0 4 2 0 0 0 0.0570 0.734 1.000 194 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB11(2), ABCB4(3), ABCC1(1), ABCC3(5) 5341135 11 10 11 3 2 3 2 2 2 0 0.366 0.734 1.000 195 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 FOSB(1) 1380104 1 1 1 0 0 0 0 0 1 0 1.000 0.736 1.000 196 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 IFNG(1), MAP3K5(4), MAP4K5(1), NFKB1(1), RELA(2), TNFRSF9(2), TRAF2(2) 7299353 13 12 13 3 2 4 1 3 3 0 0.333 0.737 1.000 197 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(1), ALDH18A1(1), ARG2(2), CPS1(1), PYCR1(2) 6614628 7 7 7 0 2 2 1 0 2 0 0.0917 0.737 1.000 198 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(1) 1264626 1 1 1 0 0 0 0 1 0 0 0.738 0.738 1.000 199 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(2), GBA(1), MPO(4), TPO(1) 3111935 8 7 8 3 0 5 0 1 2 0 0.346 0.741 1.000 200 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 MMP9(1), TIMP1(1), TIMP2(1) 2861972 3 3 3 0 0 1 1 1 0 0 0.401 0.748 1.000 201 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 MAP2K4(2), MAP2K6(2), MAP3K5(4), MAP3K7(1), MAP3K9(2), MEF2B(2), MEF2C(1), MYC(3), PLA2G4A(1), RAC1(1), RIPK1(2), STAT1(2), TGFB1(1), TGFBR1(1), TRAF2(2) 13803413 27 19 27 3 4 9 4 5 5 0 0.0223 0.750 1.000 202 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD3G(1), ITGB2(1), PTPRC(4) 4070928 6 6 6 2 2 1 3 0 0 0 0.615 0.750 1.000 203 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CREBBP(4), EP300(2), MAP2K3(2), MAP2K6(2), MAP3K7(1), MAPK11(1), NFKB1(1), RELA(2), TGFBR1(1), TGFBR2(1), TLR2(3), TNF(1) 10729764 21 18 21 4 4 4 3 7 3 0 0.247 0.757 1.000 204 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 CREBBP(4), SET(1) 3854883 5 4 5 1 1 2 0 0 2 0 0.533 0.760 1.000 205 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(1), AGTR1(1), EGFR(2), MAP2K2(1), MAP2K4(2), MAPK1(1), MEF2B(2), MEF2C(1), PAK1(1), PRKCA(1), PTK2(3), PTK2B(2), RAC1(1), SYT1(1) 12715173 20 16 20 3 2 5 3 2 8 0 0.122 0.761 1.000 206 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(2), ME1(1) 3440072 3 3 3 1 1 1 0 1 0 0 0.695 0.765 1.000 207 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 CRY1(2), CRY2(1), PER1(3), PER2(1), PER3(3) 6125878 10 7 10 1 2 5 1 2 0 0 0.115 0.765 1.000 208 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(1), CPT1A(1), PRKAA2(4), PRKAB2(1) 5307054 7 5 7 1 0 3 3 1 0 0 0.358 0.767 1.000 209 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(1), GNAS(2), PRKAR2B(1), PRKCA(1) 3604470 5 5 5 3 1 0 0 1 3 0 0.957 0.767 1.000 210 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(5), CREBBP(4), EP300(2), MAP3K7(1), SKIL(2), TGFB1(1), TGFBR1(1), TGFBR2(1) 9174057 17 15 17 4 2 3 4 2 6 0 0.506 0.768 1.000 211 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 16 CREBBP(4), EP300(2), HDAC3(1), NFKB1(1), RELA(2), RIPK1(2), TNF(1), TNFRSF1A(1), TRAF6(2) 8140100 16 14 16 3 4 5 1 4 2 0 0.232 0.771 1.000 212 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(1), ATP6AP1(2), ATP6V0A4(1), ATP6V1A(2), ATP6V1E1(1) 5561173 7 6 7 2 1 0 4 1 1 0 0.670 0.774 1.000 213 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(1), ATP6AP1(2), ATP6V0A4(1), ATP6V1A(2), ATP6V1E1(1) 5561173 7 6 7 2 1 0 4 1 1 0 0.670 0.774 1.000 214 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(1), ATP6AP1(2), ATP6V0A4(1), ATP6V1A(2), ATP6V1E1(1) 5561173 7 6 7 2 1 0 4 1 1 0 0.670 0.774 1.000 215 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ALDH1A3(2), AOC3(1), DDC(2), EPX(2), HPD(1), MAOB(1), MPO(4), TAT(2), TPO(1) 8217199 16 14 16 4 4 7 2 0 3 0 0.135 0.774 1.000 216 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(5), AXIN1(1), CREBBP(4), DVL1(2), EP300(2), TRRAP(3) 11889510 17 14 17 2 5 3 0 3 6 0 0.0855 0.780 1.000 217 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 IARS(1), PDHA2(2), PDHB(1) 3657057 4 4 4 0 0 2 1 1 0 0 0.304 0.782 1.000 218 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 ASNS(1), CA12(1), CA2(2), CA3(1), CA4(1), CA9(1), CPS1(1), GLUL(1) 6946521 9 9 9 2 3 2 3 0 1 0 0.375 0.784 1.000 219 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 CAPN1(1), CAPNS1(1), MAPT(1) 3538009 3 3 3 1 1 0 1 0 1 0 0.815 0.790 1.000 220 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS2(2), CARS(1), CARS2(1), DARS(1), EARS2(1), EPRS(1), FARSB(2), HARS2(1), IARS(1), IARS2(1), MARS(1), MARS2(1), MTFMT(1), QARS(1), RARS(2), SARS(2), TARS(1), TARS2(2), WARS(1), WARS2(1), YARS(1), YARS2(2) 19809038 28 26 28 4 3 4 11 9 1 0 0.0901 0.792 1.000 221 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTN1(1), CAPN1(1), CAPNS1(1), ITGA1(1), PTK2(3), RAC1(1), SPTAN1(3), TLN1(2) 10543511 13 11 13 1 3 1 2 2 5 0 0.260 0.793 1.000 222 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 SEC61A2(1), SRP68(1) 2759453 2 2 2 1 0 0 0 2 0 0 0.873 0.794 1.000 223 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMB3(1), PSMB6(1), PSMB9(1) 3208745 3 3 3 1 0 1 2 0 0 0 0.805 0.796 1.000 224 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(2), MAP2(3), PRKAR2B(1), PRKCE(2) 6362099 8 7 8 3 0 3 0 0 4 1 0.793 0.800 1.000 225 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ERBB4(4), NRG2(1), NRG3(1), PRKCA(1) 3367818 7 6 7 5 2 1 1 1 2 0 0.979 0.801 1.000 226 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(3), GRHPR(1), MTHFD1(1), MTHFD1L(1) 4903597 6 5 6 2 0 2 2 0 2 0 0.645 0.804 1.000 227 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 FAS(1), IL1A(1), TNF(1) 4066954 3 3 3 0 1 0 1 0 1 0 0.552 0.814 1.000 228 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 BFAR(2), BRAF(1), CAMP(1), MAPK1(1) 4278790 5 4 5 1 0 3 0 1 1 0 0.475 0.815 1.000 229 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(1), CARS2(1), LDHB(1), SULT1B1(2), SULT1C2(1), SULT4A1(1) 4679360 7 6 7 2 2 1 1 2 1 0 0.588 0.817 1.000 230 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 CAMP(1), ITPKA(1) 2108870 2 2 2 0 1 1 0 0 0 0 0.405 0.817 1.000 231 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMB3(1), PSMB6(1), PSMC3(1), RPN2(2), UBE3A(1) 4882829 6 6 6 0 0 3 1 1 1 0 0.182 0.823 1.000 232 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT1(1), ACOT11(2), DHRS2(1), DHRSX(1), ESCO2(1), FN3K(1), PNPLA3(1), SH3GLB1(1), YOD1(1) 9210733 10 10 10 1 2 3 2 2 1 0 0.150 0.826 1.000 233 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 TGDS(1), UGDH(1), UGP2(1) 1849489 3 2 3 1 0 2 0 0 1 0 0.572 0.826 1.000 234 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 HSD17B4(1), MECR(1) 3164522 2 2 2 0 0 1 0 0 1 0 0.554 0.828 1.000 235 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 NFKB1(1), RELA(2), TRAF2(2), TRAF6(2) 5400720 7 7 7 2 1 2 2 1 1 0 0.601 0.832 1.000 236 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP6(1), ALPI(1), ALPL(3), ALPP(1), CYP3A4(2), CYP3A7(1), DHRS2(1), DHRSX(1) 6603650 11 11 11 3 1 4 4 0 2 0 0.381 0.834 1.000 237 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 ST3GAL5(1) 1978331 1 1 1 1 0 0 0 1 0 0 0.935 0.834 1.000 238 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GGT1(1) 1628554 1 1 1 0 0 0 1 0 0 0 0.786 0.835 1.000 239 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 EPX(2), MPO(4), TPO(1) 4391131 7 6 7 2 0 5 0 0 2 0 0.249 0.837 1.000 240 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 APC(5), AXIN1(1), BTRC(1), DVL1(2), NOTCH1(1) 8037217 10 8 10 2 4 2 0 0 3 1 0.246 0.837 1.000 241 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(1), C1QB(1), C1S(1), C3(4), C5(2), C6(4), C7(1), C8A(1), C8B(1), C9(3), MASP1(3) 7731275 22 18 22 6 3 6 4 6 3 0 0.300 0.838 1.000 242 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 TGDS(1), UGDH(1) 1476261 2 1 2 1 0 1 0 0 1 0 0.717 0.839 1.000 243 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(5), CAMP(1), CERK(1), EPHB2(1), ITPKA(1), MAP2K4(2), MAP2K7(2), MAPK1(1), MAPK10(2), MAPK8IP3(2) 10298103 18 16 18 4 6 5 0 2 5 0 0.158 0.842 1.000 244 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 CARS(1), DARS(1), EPRS(1), IARS(1), MARS(1), MARS2(1), QARS(1), RARS(2), SARS(2), TARS(1), WARS(1), WARS2(1), YARS(1) 11623056 15 15 15 3 2 2 4 7 0 0 0.328 0.846 1.000 245 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(1), ARHGEF1(1), MYLK(3), PLCB1(4), PPP1R12B(1), PRKCA(1), ROCK1(1) 7647869 12 9 12 3 1 3 2 4 2 0 0.484 0.849 1.000 246 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 APOBEC3B(2), APOBEC3F(1), APOBEC3G(1) 2694752 4 2 4 2 0 1 1 0 2 0 0.642 0.854 1.000 247 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25B(1), CDKN1A(2), NEK1(2) 2828278 5 4 5 2 2 1 0 1 1 0 0.707 0.854 1.000 248 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(1), FCGR3A(2), IL6R(1), SELL(1), SPN(1), TGFB1(1), TNF(1), TNFRSF1A(1), TNFRSF8(1) 5113478 10 10 10 3 3 2 2 3 0 0 0.449 0.859 1.000 249 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(1), ACACB(2), FASN(3), OXSM(1) 6052197 7 7 7 2 1 0 3 2 1 0 0.586 0.859 1.000 250 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), UGDH(1) 3135641 6 5 6 3 0 1 3 1 1 0 0.832 0.865 1.000 251 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AP2A1(2), AP2M1(2), BTK(1), EEA1(5), LYN(1), PFKL(2), PFKP(1), PLCG1(2), PRKCE(2), RAC1(1), VAV2(3) 9400239 22 15 22 7 1 8 3 2 8 0 0.290 0.866 1.000 252 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMB3(1), PSMB6(1), PSMC2(2), PSMC3(1), PSMD1(1) 5885228 6 5 6 0 0 2 2 1 1 0 0.200 0.867 1.000 253 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(1) 1777909 1 1 1 1 0 0 1 0 0 0 0.916 0.868 1.000 254 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT10(1), GALNT3(1), GALNT7(1), GALNT8(2), WBSCR17(2) 5421077 7 6 7 1 1 4 2 0 0 0 0.190 0.869 1.000 255 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(1), GBA(1), GGT1(1) 2139803 3 3 3 2 0 1 1 1 0 0 0.837 0.870 1.000 256 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), AKR1D1(2), CYP11B1(3), CYP11B2(1), CYP21A2(1), HSD11B1(1), HSD3B1(1) 3644443 10 8 10 8 2 1 1 3 3 0 0.975 0.875 1.000 257 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(1), AKR1D1(2), CYP11B1(3), CYP11B2(1), CYP21A2(1), HSD11B1(1), HSD3B1(1) 3644443 10 8 10 8 2 1 1 3 3 0 0.975 0.875 1.000 258 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 MAPK1(1), PRKCA(1) 3484290 2 2 2 2 0 0 0 0 2 0 1.000 0.879 1.000 259 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1) 4441886 5 5 5 2 0 0 2 2 1 0 0.822 0.879 1.000 260 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 NFKB1(1), PIK3CA(6), PIK3R1(1), RAC1(1), RELA(2) 7287255 11 11 10 3 2 3 1 3 2 0 0.400 0.882 1.000 261 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 FYN(1), THBS1(1) 2659019 2 2 2 1 0 1 0 1 0 0 0.774 0.882 1.000 262 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(4), EP300(2), MAPK1(1) 5286334 7 6 7 2 1 1 0 2 3 0 0.749 0.885 1.000 263 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 IGF1(1), IGF1R(1), IRS1(1), PIK3CA(6), PIK3R1(1), PTPN11(3), RASA1(2), SRF(1) 9117030 16 13 15 4 2 4 2 5 2 1 0.355 0.888 1.000 264 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 MAP2K2(1), MAP2K3(2), MAP2K6(2), MAPK1(1), NFATC2(1), NFKB1(1), PAK1(1), PIK3C2G(7), PLCB1(4), PPP3CC(2), RAC1(1), RELA(2), SYT1(1) 14318033 26 23 26 5 2 7 6 7 4 0 0.182 0.889 1.000 265 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD9(1), ADH4(2), ADH7(3), DHRS2(1), DHRSX(1), ESCO2(1), PNPLA3(1), SH3GLB1(1) 8803560 11 8 11 2 1 4 2 1 3 0 0.318 0.892 1.000 266 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 PTK2B(2) 3182033 2 2 2 0 0 1 0 0 1 0 0.443 0.892 1.000 267 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CAMK2B(1), CAMK2G(1), ESRRA(1), HDAC5(1), MEF2B(2), MEF2C(1), PPARA(1), PPP3CC(2), SLC2A4(1), SYT1(1) 7673172 12 10 12 3 1 4 3 0 4 0 0.370 0.893 1.000 268 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 EIF2B3(1), EIF2S2(1), FLT1(1), FLT4(2), KDR(4), NOS3(2), PIK3CA(6), PIK3R1(1), PLCG1(2), PRKCA(1), PTK2(3) 12649913 24 23 23 5 3 2 4 10 5 0 0.324 0.895 1.000 269 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(4), EGFR(2) 3762116 6 3 6 3 0 3 1 0 2 0 0.737 0.900 1.000 270 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(2), PARK2(1), SNCAIP(1), UBE2G2(1) 2316896 5 5 5 3 1 2 1 0 1 0 0.880 0.902 1.000 271 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(2), MAPK1(1), MYC(3), NFKB1(1), PLCB1(4), PRKCA(1), RELA(2), TNF(1) 5642121 15 12 15 5 3 6 1 2 3 0 0.435 0.905 1.000 272 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 CPS1(1) 2838312 1 1 1 0 0 0 1 0 0 0 0.840 0.907 1.000 273 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 CCND1(1), CREBBP(4), EP300(2), GRIP1(2), HDAC3(1), HDAC5(1), HDAC6(2), MEF2C(1), NCOR2(3), NR0B1(2), NRIP1(3) 17251677 22 19 22 3 3 5 5 6 3 0 0.104 0.907 1.000 274 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 IGF1R(1), IRS1(1), MAPK1(1), PIK3CA(6), PIK3R1(1) 6919633 10 10 9 3 1 0 2 4 3 0 0.663 0.910 1.000 275 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 DHCR7(1), FDPS(2), HMGCS1(1), IDI1(1) 4939306 5 5 5 2 0 0 3 0 2 0 0.898 0.911 1.000 276 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS2(1), DHRSX(1), ESCO2(1), PNPLA3(1), SH3GLB1(1) 5676066 5 5 5 1 0 2 2 0 1 0 0.512 0.912 1.000 277 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(4), C5(2), C6(4), C7(1), C8A(1), C9(3) 4689168 15 13 15 5 1 2 4 6 2 0 0.586 0.913 1.000 278 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(1), C1QB(1), C1S(1), C3(4), C5(2), C6(4), C7(1), C8A(1), C9(3) 6542114 18 16 18 5 2 4 4 6 2 0 0.365 0.913 1.000 279 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 INPP1(1), INPP4B(1), INPP5A(1), INPPL1(1), ITPKA(1), PIK3C2G(7), PIK3CA(6), PIK3CB(1), PIK3CG(2), PLCB1(4), PLCB2(1), PLCB3(1), PLCB4(3), PLCG1(2) 16649135 32 28 31 7 5 7 4 11 5 0 0.205 0.914 1.000 280 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 MAP2K4(2), MAPK1(1), NFKB1(1), NSMAF(1), RELA(2), RIPK1(2), TNFRSF1A(1), TRAF2(2) 7439773 12 12 12 4 2 4 1 1 4 0 0.520 0.915 1.000 281 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 HSD17B4(1), SIRT1(1), SIRT7(1) 4374317 3 3 3 1 0 0 0 1 2 0 0.721 0.916 1.000 282 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSE(1), GAL3ST1(1), GALC(2), GBA(1), GLA(1), LCT(4), NEU3(2), PPAP2A(1), PPAP2C(1), SMPD2(1), SPTLC1(1) 8852858 16 14 15 8 2 2 2 2 8 0 0.888 0.918 1.000 283 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 33 GTF2A1L(1), GTF2B(1), GTF2H1(1), STON1(2), TAF1(3), TAF10(1), TAF1L(9), TAF2(1), TAF6(1), TAF6L(3), TBPL1(1), TBPL2(1) 13276225 25 16 25 4 7 5 6 3 4 0 0.0818 0.919 1.000 284 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR2(2), GPR34(1) 3408833 3 2 3 2 0 0 0 1 2 0 0.872 0.921 1.000 285 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 ACHE(3), CHAT(1), DBH(1), DDC(2), GAD1(1), GAD2(2), HDC(3), PAH(1), TH(1) 5366193 15 13 15 5 7 4 0 3 1 0 0.305 0.923 1.000 286 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 CD3G(1), ITGB2(1) 3162937 2 2 2 1 1 0 1 0 0 0 0.837 0.924 1.000 287 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(1), ALPL(3), ALPP(1), ASCC3(2), ATP13A2(1), DDX18(2), DDX4(1), DDX41(1), DDX50(1), DDX51(1), DDX52(1), DDX56(1), EP400(2), FPGS(1), GGH(1), IFIH1(1), MOV10L1(1), QDPR(2), RAD54B(1), RAD54L(1), RUVBL2(2), SETX(3), SMARCA2(2), SMARCA5(2) 23285243 35 28 35 6 5 10 9 4 7 0 0.0576 0.930 1.000 288 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 CDKN1A(2), EPO(1), GRIN1(2), NFKB1(1), RELA(2) 4715092 8 8 8 3 2 3 1 2 0 0 0.571 0.930 1.000 289 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 DHRS2(1), DHRSX(1), HEMK1(1), PRMT2(2), PRMT3(1), PRMT6(1), PRMT8(1), WBSCR22(1) 5462967 9 7 9 3 1 4 1 2 1 0 0.648 0.933 1.000 290 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 EPO(1) 2297874 1 1 1 0 0 0 1 0 0 0 0.803 0.934 1.000 291 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 BAG4(1), LMNB1(1), MAP2K7(2), MAP3K5(4), MDM2(1), NFKB1(1), PRKDC(5), PSEN2(1), PTK2(3), RASA1(2), RB1(24), RELA(2), RIPK1(2), SPTAN1(3), TNF(1), TNFRSF1A(1), TRAF2(2) 25670274 56 47 56 10 5 12 6 3 28 2 0.0491 0.935 1.000 292 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 EGF(4), EGFR(2), MAPK1(1), PTPRB(4), RASA1(2), SPRY3(2) 9220131 15 10 15 4 1 7 2 1 4 0 0.275 0.941 1.000 293 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(2), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), CYP2C19(2), CYP2C9(2), DHRS2(1), DHRSX(1), ESCO2(1), PNPLA3(1), SH3GLB1(1), YOD1(1) 10997634 17 16 17 4 2 4 7 2 2 0 0.354 0.942 1.000 294 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(5), CDK4(1), DAZL(1), EGR1(1), ESR2(2), GJA4(1), INHA(1), LHCGR(5), MLH1(1), NCOR1(1), NRIP1(3), PRLR(4), PTGER2(2) 12606380 28 22 27 7 1 7 7 6 7 0 0.469 0.943 1.000 295 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(4), EGFR(2), NCOR2(3), RARA(1), RXRA(1), THRA(1) 6512941 12 8 12 4 1 5 2 1 3 0 0.435 0.943 1.000 296 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 MAPK1(1), MAPK7(1), MEF2B(2), MEF2C(1), NTRK1(3), PIK3CA(6), PIK3R1(1), PLCG1(2), RPS6KA1(1) 7227556 18 14 17 5 5 3 1 4 5 0 0.369 0.944 1.000 297 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 B4GALT5(2), FUT8(1), MAN1A1(3), MAN1B1(1), MGAT3(1), RPN2(2) 7236033 10 6 10 1 2 4 1 1 2 0 0.0926 0.945 1.000 298 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 33 MAP2K4(2), MAP2K7(2), MAPK1(1), MAPK10(2), MAPK11(1), MAPK8IP3(2), NFKB1(1), NFKBIL1(1), PIK3CA(6), PIK3CD(1), PIK3R1(1), SYT1(1), TRAF2(2), TRAF6(2) 12825279 25 21 24 6 4 6 3 6 6 0 0.229 0.947 1.000 299 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 EPHA4(2), EPHB1(2), FYN(1), ITGA1(1), L1CAM(1), LYN(1), SELP(2) 5712243 10 9 10 4 2 3 1 3 1 0 0.660 0.951 1.000 300 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 DAB1(2), FYN(1), LRP8(1), RELN(6) 5077091 10 8 10 4 2 3 0 2 3 0 0.577 0.952 1.000 301 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(1), FDPS(2), IDI1(1) 4142364 4 4 4 2 0 0 2 0 2 0 0.933 0.953 1.000 302 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLD1(2), POLE(5), POLG(1), POLQ(6), PRIM2(1), REV1(1), REV3L(2) 15199092 18 14 18 2 1 6 7 1 3 0 0.164 0.954 1.000 303 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 F13B(1), HSD17B1(1), HSD17B2(1), HSD17B4(1), HSD3B1(1) 2925473 5 5 5 4 1 0 0 3 1 0 0.941 0.954 1.000 304 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(2), CYP11B2(1), HSD11B1(1), HSD3B1(1) 2510238 5 4 5 6 1 2 0 1 1 0 0.963 0.955 1.000 305 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(1), ACSL3(1), ACSL4(2), CPT1A(1), SLC25A20(1) 6147583 6 6 6 2 1 1 2 2 0 0 0.683 0.956 1.000 306 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(3), IDH1(2), IDH3A(1), IDH3B(1), IDH3G(1), SDHA(1) 7574163 9 7 9 2 2 3 3 0 1 0 0.285 0.958 1.000 307 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ADH4(2), ADH7(3), AKR1C4(1), AKR1D1(2), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), CEL(3), CYP27A1(1), SOAT2(1) 8569961 18 14 18 5 2 3 3 6 4 0 0.495 0.958 1.000 308 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ARPC1B(1), RAC1(1) 3018007 2 2 2 0 1 1 0 0 0 0 0.449 0.958 1.000 309 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 COASY(1), DPYD(6), ENPP3(2), ILVBL(1), PANK1(1), PANK3(1), PPCS(1) 6457368 13 11 13 4 0 5 3 2 3 0 0.391 0.960 1.000 310 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(4), EP300(2), LPL(2), NCOA1(1), RXRA(1) 6619577 10 8 10 3 2 1 2 3 2 0 0.735 0.960 1.000 311 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CDC25B(1), PRKCA(1), PTPRA(1) 3424273 3 3 3 4 0 2 0 0 1 0 0.980 0.962 1.000 312 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 HLA-DRB1(1), IFNA1(1), IFNG(1), IL1A(1), TGFB1(1), TNF(1) 4970754 6 6 6 3 2 0 2 2 0 0 0.747 0.963 1.000 313 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 HEMK1(1), PRMT2(2), PRMT3(1), PRMT6(1), PRMT8(1), WBSCR22(1) 5190245 7 5 7 3 1 3 0 2 1 0 0.804 0.963 1.000 314 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(1) 2894151 1 1 1 0 0 0 0 1 0 0 0.774 0.964 1.000 315 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 31 ANPEP(1), GCLC(1), GGT1(1), GPX5(2), GSTA4(1), GSTM5(1), IDH1(2) 6829647 9 8 9 3 2 1 3 0 3 0 0.745 0.966 1.000 316 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(1), ACACA(1), ACADL(1), ACADSB(1), ACAT1(1), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), LDHB(1), MUT(2) 12096851 13 13 13 3 0 1 4 5 3 0 0.581 0.969 1.000 317 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(2), CAPNS1(1), EP300(2), NFATC2(1), PPP3CC(2), PRKCA(1), SYT1(1) 8786511 10 10 10 3 0 1 2 3 4 0 0.815 0.969 1.000 318 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAT1(1) 3099511 1 1 1 0 0 0 0 1 0 0 0.754 0.969 1.000 319 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 MEF2B(2), MEF2C(1) 3144047 3 2 3 2 1 1 0 0 1 0 0.853 0.970 1.000 320 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 EGR2(1), MYC(3), NFATC2(1), NFKB1(1), PLCG1(2), PPP3CC(2), PRKAR2B(1), RELA(2), SYT1(1) 9997608 14 13 14 4 2 4 2 2 4 0 0.534 0.970 1.000 321 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 IL6R(1), JAK1(1), JAK3(2), PTPN11(3), SRF(1) 8910453 8 7 8 2 2 1 2 2 0 1 0.521 0.970 1.000 322 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 APC(5), AXIN1(1), BMP5(1), BMPR2(1), CHRD(2), DVL1(2), GATA4(1), MAP3K7(1), MEF2C(1), NKX2-5(1), TGFB1(1), TGFBR1(1), TGFBR2(1), TGFBR3(2) 13214897 21 16 21 4 3 4 4 3 7 0 0.290 0.971 1.000 323 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F2R(1), F5(5), F7(1), FGA(2), FGB(2), FGG(2), PROS1(1), TFPI(1) 6023711 15 15 15 5 1 4 4 4 2 0 0.587 0.971 1.000 324 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CD3G(1), FYN(1), LCK(1), MAP2K4(2), NFATC2(1), NFKB1(1), PIK3CA(6), PIK3R1(1), PLCG1(2), PPP3CC(2), PRKCA(1), PTPN7(1), RAC1(1), RASA1(2), RELA(2), SYT1(1), VAV1(3), ZAP70(5) 17506582 34 27 33 6 5 10 4 8 7 0 0.0587 0.971 1.000 325 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ADH4(2), ADH7(3), ALDH1A3(2), AOC3(1), AOX1(2), DBH(1), DCT(2), DDC(2), HPD(1), MAOB(1), TAT(2), TH(1), TPO(1), TYR(2) 11791871 23 17 23 6 5 9 4 2 3 0 0.214 0.973 1.000 326 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 IL2RG(1), IRS1(1), JAK1(1), JAK3(2) 5484854 5 5 5 2 1 0 3 1 0 0 0.720 0.973 1.000 327 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 CES1(1) 4144999 1 1 1 1 1 0 0 0 0 0 0.904 0.974 1.000 328 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 CBS(1), GGT1(1), HEMK1(1), MARS(1), MARS2(1), PRMT2(2), PRMT3(1), PRMT6(1), PRMT8(1), SEPHS1(1), WBSCR22(1) 9279862 12 10 12 4 2 3 3 3 1 0 0.645 0.974 1.000 329 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(1), LDHB(1) 3341850 2 2 2 3 1 0 0 0 1 0 0.993 0.974 1.000 330 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 SCAP(4), SREBF1(2), SREBF2(1) 6712979 7 6 7 2 1 2 2 1 1 0 0.517 0.974 1.000 331 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 SNAP29(1), STX16(2), STX7(1), TSNARE1(1), VAMP7(1), YKT6(2) 6291693 8 5 8 2 2 2 2 0 1 1 0.472 0.974 1.000 332 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT1(2), CHPF(1), CHST11(1), CHST14(1), CHST3(1), DSE(2), XYLT2(2) 5232376 10 7 10 4 2 6 0 1 1 0 0.391 0.975 1.000 333 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 28 BAG4(1), MAP2K4(2), MAP3K7(1), NFKB1(1), NFKBIL1(1), RIPK1(2), TNF(1), TNFRSF1A(1), TRAF2(2) 10333966 12 12 12 3 2 4 3 1 2 0 0.368 0.976 1.000 334 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(1), DHRS2(1), DHRSX(1) 3245129 3 3 3 2 0 1 2 0 0 0 0.819 0.976 1.000 335 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(1), JUNB(1), MAP2K3(2), NFATC2(1), PRKAR2B(1) 4424361 6 6 6 3 0 0 3 1 2 0 0.912 0.976 1.000 336 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 BLVRB(2), CP(3), EPRS(1), GUSB(2), HCCS(1), HMOX1(1), HMOX2(1), PPOX(1), UGT1A10(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT2B15(1) 9972389 18 16 18 5 5 3 3 2 5 0 0.560 0.976 1.000 337 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 ASNS(1), ASRGL1(1), CA12(1), CA2(2), CA3(1), CA4(1), CA9(1), CPS1(1), GLUL(1) 7743058 10 10 10 3 3 3 3 0 1 0 0.462 0.977 1.000 338 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 43 EGF(4), EGFR(2), MAP2K3(2), MAP2K4(2), MAP2K6(2), MAP2K7(2), MAP3K5(4), MAPK1(1), NFKB1(1), PRKCA(1), PRKCE(2), PRKCG(1), PRKCH(1), PRKCQ(2), RELA(2), RIPK1(2), SP1(2), TNF(1), TNFRSF1A(1), TRAF2(2) 18009646 37 26 37 9 5 14 4 5 9 0 0.104 0.978 1.000 339 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 NOTCH1(1) 3725415 1 1 1 2 0 0 0 0 0 1 0.987 0.980 1.000 340 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 DIAPH2(3), MCM10(3), MCM3(1), MCM4(1), MCM5(1), MCM7(1), NACA(2), POLD1(2), POLE(5), RPA1(1), RPA4(1), UBB(2) 18445356 23 19 23 3 3 7 7 2 4 0 0.0576 0.980 1.000 341 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 CAPN1(1), CAPNS1(1), EGF(4), EGFR(2), ITGA1(1), MAPK1(1), MYLK(3), PRKAR2B(1), PTK2(3), TLN1(2) 12183583 19 14 19 5 3 3 5 1 7 0 0.493 0.981 1.000 342 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(1), PRKAR2B(1) 3625301 2 2 2 2 0 0 0 1 1 0 0.979 0.981 1.000 343 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(1), ACAT1(1), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), DLAT(1), GRHPR(1), LDHB(1), ME1(1), ME3(1), PDHA2(2), PDHB(1), PKLR(2) 13551492 17 14 17 3 2 3 5 4 3 0 0.241 0.983 1.000 344 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B4GALT5(2), FUT8(1) 2840489 3 1 3 0 1 2 0 0 0 0 0.238 0.983 1.000 345 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AASDHPPT(1), AASS(1), ACAT1(1), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), BBOX1(2), EHMT2(1), PLOD2(2), PLOD3(1), TMLHE(1) 13605369 15 15 15 4 1 2 3 6 3 0 0.511 0.983 1.000 346 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 GLI2(1), GLI3(1), PRKAR2B(1), SUFU(2) 6043791 5 5 5 2 0 1 0 1 3 0 0.791 0.984 1.000 347 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(2), ACTB(1), ARHGEF2(1), CLDN1(1), CTTN(3), EZR(1), FYN(1), HCLS1(2), KRT18(1), NCK2(1), OCLN(1), PRKCA(1), ROCK1(1), ROCK2(1), TLR4(1), TLR5(2), TUBA3C(3), TUBA3E(1), TUBA4A(1), TUBA8(1), TUBAL3(2), TUBB2B(2), TUBB8(3) 19343457 34 29 33 9 5 7 7 9 6 0 0.330 0.984 1.000 348 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(2), ACTB(1), ARHGEF2(1), CLDN1(1), CTTN(3), EZR(1), FYN(1), HCLS1(2), KRT18(1), NCK2(1), OCLN(1), PRKCA(1), ROCK1(1), ROCK2(1), TLR4(1), TLR5(2), TUBA3C(3), TUBA3E(1), TUBA4A(1), TUBA8(1), TUBAL3(2), TUBB2B(2), TUBB8(3) 19343457 34 29 33 9 5 7 7 9 6 0 0.330 0.984 1.000 349 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 SDHA(1) 3462884 1 1 1 0 0 0 1 0 0 0 0.815 0.984 1.000 350 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(2), STAT5A(1) 6612993 3 3 3 1 1 0 2 0 0 0 0.715 0.985 1.000 351 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ELOVL2(1), FADS1(1), FADS2(1), FASN(3), HSD17B12(1) 5582821 7 7 7 3 1 2 2 1 1 0 0.653 0.985 1.000 352 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ARHGAP5(1), ARHGEF1(1), ARHGEF11(1), ARHGEF5(1), ARPC1B(1), BAIAP2(2), DIAPH1(2), LIMK1(2), MYLK(3), OPHN1(1), PIP5K1A(1), PIP5K1B(1), PPP1R12B(1), ROCK1(1), TLN1(2) 16981168 21 16 21 4 5 4 5 4 3 0 0.219 0.985 1.000 353 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 GNE(1), HK2(2) 6289088 3 3 3 1 1 0 1 1 0 0 0.798 0.986 1.000 354 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 ITGAM(2), ITGB2(1), SELL(1) 3972147 4 4 4 3 1 1 0 1 1 0 0.879 0.987 1.000 355 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(1), IFNAR1(1), JAK1(1), STAT1(2) 4062865 5 5 5 6 0 1 2 1 1 0 0.986 0.987 1.000 356 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAD9(1), ADH4(2), ADH7(3), AKR1B10(1), AKR1C4(1), AKR1D1(2), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), CEL(3), CYP27A1(1), LIPA(1), SLC27A5(1), SOAT1(1), SOAT2(1) 11842612 23 18 23 6 3 5 5 5 5 0 0.348 0.987 1.000 357 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(1), CABIN1(2), CAMK2B(1), CD3G(1), CDKN1A(2), CNR1(3), CREBBP(4), CTLA4(1), EGR2(1), EP300(2), FCER1A(1), FCGR3A(2), GATA3(1), GATA4(1), IFNA1(1), IFNG(1), JUNB(1), MAP2K7(2), MEF2B(2), MYF5(1), NCK2(1), NFAT5(4), NFATC2(1), P2RX7(1), PAK1(1), PIN1(1), PPP3CC(2), PTPRC(4), RELA(2), RPL13A(1), SLA(2), SP1(2), SP3(2), TGFB1(1), TNF(1), TRAF2(2), TRPV6(2), VAV1(3), VAV2(3), VAV3(1) 33558926 68 50 68 11 11 13 18 14 12 0 0.0152 0.988 1.000 358 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 ANKHD1(1), EEF1G(2), EIF2AK3(2), EIF2B3(1), EIF2S2(1), EIF4A2(2), EIF4G1(1), EIF4G3(3), EIF5B(1), GSPT2(1), PABPC1(2), PABPC3(2), PAIP1(1), SLC35A4(1) 16391173 21 17 21 4 3 7 1 5 5 0 0.210 0.989 1.000 359 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CD3G(1), ETV5(2), IFNG(1), IL12RB1(1), IL12RB2(3), IL18R1(1), MAP2K6(2), STAT4(1) 6972139 12 11 12 7 0 3 2 4 3 0 0.894 0.989 1.000 360 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(1), DHCR7(1), FDPS(2), GGCX(1), IDI1(1), TM7SF2(1) 7147873 7 7 7 3 1 1 2 1 2 0 0.796 0.989 1.000 361 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(1), GNAS(2), PLCE1(4), PRKAR2B(1) 5396535 8 8 8 6 3 2 0 1 2 0 0.937 0.990 1.000 362 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCR3(1), GNAS(2), LIMK1(2), MAPK1(1), NOX1(1), PIK3C2G(7), PLCB1(4), PPP1R12B(1), PRKCA(1), PTK2(3), ROCK2(1) 9407742 24 20 24 9 1 6 6 7 4 0 0.749 0.990 1.000 363 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(5), CDC25B(1), MYT1(2) 5032919 8 7 8 5 0 4 2 1 1 0 0.929 0.991 1.000 364 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ALDH1A3(2), AOC3(1), DDC(2), EPX(2), ESCO2(1), HPD(1), MAOB(1), MPO(4), PNPLA3(1), SH3GLB1(1), TAT(2), TPO(1) 12365103 19 15 19 5 4 8 3 0 4 0 0.184 0.991 1.000 365 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CREBBP(4), EP300(2), PRKAR2B(1), RARA(1), RXRA(1) 7456995 9 8 9 4 2 1 1 2 3 0 0.864 0.991 1.000 366 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(2), BST1(2), ENPP3(2), NADK(1), NMNAT1(1), NT5E(1), NUDT12(1) 7926667 10 9 10 5 2 2 2 1 2 1 0.793 0.991 1.000 367 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(1), JAK3(2), MAPK1(1) 4482752 4 4 4 4 1 0 1 1 1 0 0.982 0.991 1.000 368 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 CASP4(2), LMNB1(1) 7040498 3 3 3 1 0 3 0 0 0 0 0.553 0.991 1.000 369 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 IRS1(1), MAPK1(1), PIK3CA(6), PIK3R1(1), PLCG1(2), PRKCA(1), RPS6KA1(1), SLC2A4(1), SRF(1), STAT5A(1) 12138491 16 16 15 5 2 2 2 4 5 1 0.611 0.992 1.000 370 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 CHRNG(1), MUSK(1), PIK3CA(6), PIK3R1(1), PTK2(3), PTK2B(2), TERT(1) 6161635 15 12 14 5 2 2 3 4 4 0 0.475 0.992 1.000 371 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 ITGA4(1), ITGB2(1), SELL(1) 4542968 3 3 3 2 1 0 1 1 0 0 0.901 0.992 1.000 372 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1R(2), E2F4(2), ETV3(1), HDAC5(1), NCOR2(3), SIN3A(1) 10044095 10 8 10 2 1 4 2 3 0 0 0.237 0.993 1.000 373 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 IFNA1(1), IL1A(1), IL1RN(1), IRAK2(1), IRAK3(2), MAP2K3(2), MAP2K6(2), MAP3K7(1), NFKB1(1), RELA(2), TGFB1(1), TNF(1), TRAF6(2) 11025206 18 17 18 5 3 2 6 6 1 0 0.491 0.993 1.000 374 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(1), FCER1A(1), LYN(1), MAP2K4(2), MAP2K7(2), MAPK1(1), NFATC2(1), PIK3CA(6), PIK3R1(1), PLA2G4A(1), PLCG1(2), PPP3CC(2), SYK(1), SYT1(1), VAV1(3) 15665266 26 23 25 7 4 4 3 8 7 0 0.419 0.994 1.000 375 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(1), CAMK2B(1), CAMK2G(1), GNAS(2), MAPK1(1), PIK3CA(6), PIK3R1(1), PRKAR2B(1), PRKCA(1), RAC1(1), RPS6KA1(1) 10751678 17 17 16 6 3 2 2 4 6 0 0.700 0.994 1.000 376 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 HK2(2), PGM1(1), TGDS(1) 3809371 4 3 4 2 1 1 1 0 1 0 0.724 0.994 1.000 377 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT6(2), ENPP2(2), PAFAH1B3(1), PAFAH2(2), PLA2G12B(1), PLA2G2D(1), PLA2G4A(1), PLD1(2), PPAP2A(1), PPAP2C(1) 8727858 14 12 14 7 4 3 2 1 4 0 0.862 0.994 1.000 378 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOB(2), GPT2(2), ME1(1), ME3(1), PGK2(1), PKLR(2), TKT(1), TKTL1(2), TKTL2(1) 7238638 13 12 13 6 5 0 3 2 3 0 0.738 0.995 1.000 379 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(1), JAK1(1), PTPRU(7), STAT1(2) 4669703 11 11 11 8 2 2 3 3 1 0 0.938 0.995 1.000 380 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 LCT(4), MAN2C1(1), NEU3(2) 6052279 7 6 7 4 1 1 2 0 2 1 0.768 0.995 1.000 381 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 GUSB(2), UGDH(1), UGT1A10(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT2B15(1) 6396210 9 9 9 5 4 2 0 1 2 0 0.848 0.995 1.000 382 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 DPM2(1), EGFR(2), GNAS(2), IGF1R(1), MAP2K2(1), MAPK1(1), MYC(3), NGFR(1), PDGFRA(1), PTPRR(2), RPS6KA1(1) 12464322 16 11 16 4 5 4 1 3 3 0 0.307 0.995 1.000 383 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 GNE(1), HK2(2), LHPP(2) 10645646 5 5 5 0 2 0 2 1 0 0 0.258 0.995 1.000 384 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(1), ACACA(1), ACACB(2), ACAT1(1), ACSS2(2), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), LDHB(1), MUT(2) 14489006 15 15 15 4 1 1 5 4 4 0 0.596 0.995 1.000 385 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(2), ENPP3(2), NMNAT1(1), NT5E(1) 5331520 6 6 6 4 1 2 2 0 1 0 0.882 0.995 1.000 386 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 BTK(1), CDKN2A(1), IARS(1), INPP5D(3), PIK3CA(6), PPP1R13B(1), PTEN(8), RPS6KA1(1), TEC(2), YWHAE(1) 13153299 25 22 24 9 4 5 1 9 6 0 0.754 0.996 1.000 387 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(1), ACADL(1), ACADSB(1), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), AOC3(1), DPYD(6), GAD1(1), GAD2(2) 10594907 18 14 18 6 1 5 3 5 4 0 0.484 0.996 1.000 388 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(1), GNAS(2), PRKAA2(4), PRKAB2(1), PRKAR2B(1) 5675046 9 7 9 4 2 3 2 1 1 0 0.755 0.996 1.000 389 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 CABIN1(2), HDAC5(1), IGF1(1), IGF1R(1), MAP2K6(2), MAPK7(1), MEF2B(2), MEF2C(1), NFATC2(1), PIK3CA(6), PIK3R1(1), PPP3CC(2), SYT1(1) 12839261 22 18 21 5 2 4 4 7 5 0 0.284 0.996 1.000 390 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 CRY1(2), CRY2(1), G0S2(1), IDI1(1), MYF6(1), NCKAP1(2), NCOA4(1), NR1D2(1), PER1(3), PER2(1), SF3A3(1), SUMO3(2), UGP2(1), ZFR(1) 13383825 19 18 19 5 1 7 2 4 5 0 0.564 0.996 1.000 391 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2R(1), ITGA1(1), MAPK1(1), PLA2G4A(1), PLCB1(4), PRKCA(1), PTK2(3), SYK(1), TBXAS1(1) 8965678 14 12 14 6 1 3 4 3 3 0 0.850 0.996 1.000 392 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH4(2), ADH7(3), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), CEL(3), DGKB(1), DGKD(2), DGKE(1), DGKG(3), DGKH(2), GLA(1), LCT(4), LIPC(3), LIPF(1), LPL(2), PNLIPRP1(1), PPAP2A(1), PPAP2C(1) 18030191 36 28 35 9 4 8 10 7 7 0 0.255 0.996 1.000 393 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 PRKAR2B(1) 4648994 1 1 1 6 0 0 0 0 1 0 1.000 0.996 1.000 394 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 35 ARHGEF11(1), MAP2K4(2), MAP3K5(4), NFKB1(1), NFKBIL1(1), PHKA2(2), PI3(1), PIK3CB(1), PLD1(2), PTK2(3), RDX(1), ROCK1(1), ROCK2(1), SERPINA4(1), SRF(1) 18463537 23 19 23 5 3 5 2 9 3 1 0.337 0.997 1.000 395 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(1), ABCC2(2), CES1(1), CYP3A4(2), UGT1A10(1), UGT1A4(1), UGT1A5(2), UGT1A6(1) 8298566 11 11 11 7 4 1 2 1 3 0 0.915 0.997 1.000 396 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ADCY1(1), GNAS(2), MAPK1(1), MYT1(2), PIN1(1), PRKAR2B(1), RPS6KA1(1) 7545398 9 7 9 6 2 3 0 1 3 0 0.916 0.997 1.000 397 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(1), GPLD1(1), PGAP1(2), PIGB(1), PIGC(1), PIGG(1), PIGN(3), PIGT(1) 9131825 11 9 11 4 0 7 0 3 1 0 0.449 0.997 1.000 398 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 32 MAP2K3(2), MAP2K4(2), MAP2K6(2), MAP3K7(1), NFKB1(1), PPARA(1), RELA(2), TIRAP(1), TLR2(3), TLR3(2), TLR4(1), TLR9(2), TRAF6(2) 13440229 22 19 22 6 2 4 5 9 2 0 0.363 0.997 1.000 399 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 IL2RB(4), IL2RG(1), IRS1(1), JAK1(1), JAK3(2), MAPK1(1), MYC(3), NMI(1), PIK3CA(6), PIK3R1(1), STAT5A(1), SYK(1) 13502906 23 19 22 6 6 3 4 5 5 0 0.378 0.997 1.000 400 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(1), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), AOC3(1), DPYD(6), GAD1(1), GAD2(2) 9858766 16 12 16 6 1 5 3 3 4 0 0.556 0.997 1.000 401 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(1), CFTR(6), GNAS(2), PRKAR2B(1) 4827266 10 9 10 6 3 1 0 5 1 0 0.902 0.997 1.000 402 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 37 ANPEP(1), GCLC(1), GGT1(1), GPX5(2), GSTA4(1), GSTM5(1), IDH1(2) 8323747 9 8 9 6 2 1 3 0 3 0 0.961 0.997 1.000 403 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(2), IL22RA1(1), JAK1(1), JAK3(2), STAT1(2), STAT5A(1) 7003827 9 8 9 4 2 2 2 1 2 0 0.663 0.997 1.000 404 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CR1(3), CR2(2), FCGR2B(1), HLA-DRB1(1), ITGB2(1), PTPRC(4) 5597588 12 10 12 5 3 5 3 0 1 0 0.599 0.998 1.000 405 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2B(1), CAMK2G(1), ITPKA(1), ITPR1(4), ITPR2(6), ITPR3(2), NFAT5(4), PDE6A(1), PDE6B(3), PDE6C(1), SLC6A13(1), TF(1) 13192253 26 22 26 7 9 4 4 3 6 0 0.232 0.998 1.000 406 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 DLAT(1), IDH3A(1), IDH3B(1), IDH3G(1), PDHA2(2), PDHB(1), PDHX(1), SDHA(1) 10469823 9 8 9 2 1 4 3 1 0 0 0.324 0.998 1.000 407 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 27 ADRBK1(1), ITPKA(1), ITPR1(4), ITPR2(6), ITPR3(2), NFKB1(1), NFKBIL1(1), PHKA2(2), PIK3CB(1), PLD1(2), VN1R1(1) 16943954 22 20 22 5 7 5 2 4 4 0 0.234 0.998 1.000 408 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 HK2(2), PGM1(1), TGDS(1) 4370355 4 3 4 2 1 1 1 0 1 0 0.709 0.998 1.000 409 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(1), CD3G(1), CREBBP(4), GNAS(2), HLA-DRB1(1), LCK(1), PRKAR2B(1), PTPRC(4), ZAP70(5) 8437568 20 18 20 7 7 5 3 2 3 0 0.520 0.998 1.000 410 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(1), CD3G(1), CREBBP(4), GNAS(2), HLA-DRB1(1), LCK(1), PRKAR2B(1), PTPRC(4), ZAP70(5) 8437568 20 18 20 7 7 5 3 2 3 0 0.520 0.998 1.000 411 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(1), AGTR2(1), CAMK2B(1), CAMK2G(1), FYN(1), GNA11(1), MAP2K2(1), MAPK1(1), MAPT(1), MYLK(3), PLCG1(2), PRKCA(1), PTK2B(2), STAT1(2), STAT5A(1), SYT1(1) 15510767 21 16 21 5 3 5 4 2 7 0 0.238 0.998 1.000 412 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CD3G(1), IFNG(1), IL12RB1(1), IL12RB2(3), STAT4(1) 5504250 7 7 7 5 0 3 2 1 1 0 0.920 0.998 1.000 413 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGEF2(1), GBF1(3), GPLD1(1) 5911936 5 4 5 2 1 2 2 0 0 0 0.713 0.998 1.000 414 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 GUSB(2), UGDH(1), UGP2(1), UGT1A10(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT2A3(1), UGT2B11(3), UGT2B15(1), UGT2B17(2) 9907577 16 14 16 5 5 5 2 2 2 0 0.489 0.998 1.000 415 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOB(2), GPT2(2), ME1(1), ME3(1), PKLR(2), TKT(1) 6507079 9 9 9 5 5 0 1 1 2 0 0.762 0.998 1.000 416 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLRMT(1) 5006457 1 1 1 3 0 0 0 0 1 0 1.000 0.998 1.000 417 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 ITGA4(1), ITGAM(2), ITGB2(1), SELL(1), SELP(2) 6007642 7 7 7 5 1 1 2 2 1 0 0.927 0.999 1.000 418 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 IRS1(1), PIK3CA(6), PIK3R1(1), PTPN11(3), RASA1(2), SLC2A4(1), SRF(1) 9352281 15 13 14 5 2 4 2 4 2 1 0.520 0.999 1.000 419 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 13 IKBKAP(2), NFKB1(1), RELA(2), TRAF6(2) 6801910 7 6 7 3 1 3 1 2 0 0 0.657 0.999 1.000 420 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ASPH(3), EP300(2), EPO(1), NOS3(2) 6287377 8 8 8 6 0 1 2 4 1 0 0.952 0.999 1.000 421 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AP2A1(2), AP2M1(2), DNM1(2), NME2(1), PPP3CC(2), SYNJ1(1), SYNJ2(1), SYT1(1) 8415720 12 9 12 5 1 4 3 1 3 0 0.712 0.999 1.000 422 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL3(1), CCR1(1), CCR3(1), CCR4(1), IFNG(1), IL12RB1(1), IL12RB2(3), IL18R1(1), TGFB1(1) 7358740 11 11 11 5 1 3 4 1 2 0 0.619 0.999 1.000 423 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(2), ACO1(3), CLYBL(1), IDH1(2), IDH3A(1), IDH3B(1), IDH3G(1), OGDHL(3), SDHA(1) 10930539 15 13 15 5 2 6 3 1 3 0 0.364 0.999 1.000 424 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 DRD1(1), DRD2(1), GRM1(1), PLCB1(4), PRKAR2B(1) 5751073 8 7 8 4 1 3 0 3 1 0 0.755 0.999 1.000 425 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ALPI(1), ALPL(3), ALPP(1), CYP19A1(1), CYP1A2(2), CYP2A13(1), CYP2A6(1), CYP2C18(3), CYP2C19(2), CYP2C9(2), CYP2E1(2), CYP2F1(2), CYP2J2(2), CYP3A4(2), CYP3A7(1), CYP4B1(1) 10928803 27 20 27 9 4 9 7 2 5 0 0.262 0.999 1.000 426 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACADL(1), ACADSB(1), ACAT1(1), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), AOX1(2), BCKDHA(1), MCCC1(1), MUT(2) 13231432 14 13 14 4 0 3 3 6 2 0 0.541 0.999 1.000 427 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXTL3(2), GLCE(2), HS3ST1(1), HS3ST3A1(1), HS3ST3B1(1), HS3ST5(2), HS6ST1(1), NDST3(3), NDST4(3) 7691080 16 14 16 9 3 5 3 3 2 0 0.845 0.999 1.000 428 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 52 AGT(1), CREBBP(4), ELSPBP1(2), GATA4(1), IGF1(1), MAPK1(1), MEF2C(1), MYH2(6), NFATC2(1), NKX2-5(1), PIK3CA(6), PIK3R1(1), PPP3CC(2), PRKAR2B(1), SYT1(1) 18401574 30 24 29 9 3 4 6 5 12 0 0.753 0.999 1.000 429 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AOC3(1), CES1(1), ESCO2(1), LIPA(1), PLA1A(2), PNPLA3(1), SH3GLB1(1) 9031357 8 7 8 3 3 3 1 0 1 0 0.535 0.999 1.000 430 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(1), GPRC5B(1), GPRC5C(3), GRM1(1), GRM3(5), GRM4(1), GRM5(4), GRM7(2), GRM8(2) 7481685 20 14 20 8 5 7 3 4 1 0 0.409 0.999 1.000 431 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 LCT(4), MAN2B2(1), MAN2C1(1), NEU3(2) 7470158 8 7 8 4 2 1 2 0 2 1 0.669 0.999 1.000 432 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(1), EGFR(2), ERBB4(4), ETV7(1), FMN2(5), KRAS(2), MAPK1(1), NOTCH1(1), NOTCH2(1), NOTCH3(3), NOTCH4(6), PIWIL1(2), PIWIL2(1), PIWIL3(1), SPIRE1(2) 19676771 33 24 33 9 8 7 8 6 3 1 0.293 0.999 1.000 433 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOB(2), DERA(1), H6PD(2), PFKL(2), PFKP(1), PGM1(1), TKT(1), TKTL1(2), TKTL2(1) 8949270 13 10 13 6 2 2 4 1 4 0 0.690 0.999 1.000 434 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(1), EPHB2(1), MAP2K5(1), MAPK1(1), MAPK7(1), PLD1(2), PTK2(3), RASAL1(1), TEC(2), VAV1(3) 10194330 16 14 16 7 5 1 3 4 3 0 0.825 0.999 1.000 435 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 IRS1(1), JAK1(1), JAK3(2), MAP4K1(3), MAPK1(1), PIK3CA(6), PIK3CD(1), PIK3R1(1), PPP1R13B(1) 13451939 17 16 16 7 4 0 3 4 6 0 0.808 0.999 1.000 436 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(1), ACACB(2), ACAT1(1), ACSS2(2), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), DLAT(1), GRHPR(1), LDHB(1), ME1(1), ME3(1), PDHA2(2), PDHB(1), PKLR(2) 17083347 21 18 21 5 3 3 7 4 4 0 0.325 0.999 1.000 437 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(3), ATP5B(1), ATP5C1(1), ATP5J2(1), ATP5O(1), ATP6AP1(2), ATP6V0A4(1), ATP6V1A(2), ATP6V1E1(1), COX10(1), COX6A2(1), LHPP(2), NDUFA13(1), NDUFA7(2), NDUFV3(1), SDHA(1), TCIRG1(1), UQCRB(1), UQCRC1(1) 20835732 25 24 25 6 4 4 10 2 5 0 0.323 0.999 1.000 438 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(1), ABAT(1), ACAT1(1), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), GAD1(1), GAD2(2), PDHA2(2), PDHB(1) 9468360 14 12 14 6 0 4 3 5 2 0 0.738 0.999 1.000 439 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 GRIN1(2), GRIN2A(2), GRIN2D(1), NOS1(6), PPP3CC(2), PRKAR2B(1), PRKCA(1), SYT1(1) 9313710 16 14 16 8 3 4 4 2 3 0 0.800 0.999 1.000 440 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 144 APC(5), AXIN1(1), AXIN2(2), BTRC(1), CAMK2B(1), CAMK2G(1), CCND1(1), CHD8(3), CREBBP(4), CTBP1(1), CUL1(3), DKK2(1), DVL1(2), EP300(2), FZD2(1), FZD3(2), FZD5(1), FZD6(1), LRP5(2), MAP3K7(1), MAPK10(2), MMP7(1), MYC(3), NFAT5(4), NFATC2(1), NKD2(2), PLCB1(4), PLCB2(1), PLCB3(1), PLCB4(3), PORCN(2), PPP2R1A(1), PPP2R1B(1), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), PPP3CC(2), PRICKLE1(1), PRKACA(2), PRKCA(1), PRKCG(1), RAC1(1), ROCK1(1), ROCK2(1), SMAD3(1), SOX17(1), TCF7L1(1), TCF7L2(1), TP53(90), VANGL1(1), WIF1(3), WNT10B(1), WNT2(1), WNT5A(1), WNT7B(1), WNT8A(1), WNT8B(1) 58794795 179 114 164 32 25 32 27 35 60 0 0.000470 0.999 1.000 441 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 BAIAP2(2), GAPDH(1), MAGI1(3), MAGI2(3), RERE(2), WWP1(2), WWP2(1) 8528670 14 12 14 5 1 4 2 5 2 0 0.598 1.000 1.000 442 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BLNK(2), BTK(1), LYN(1), NFATC2(1), PLCG1(2), PPP3CC(2), PRKCA(1), RAC1(1), SYK(1), SYT1(1), VAV1(3) 13930385 16 15 16 9 3 2 3 3 5 0 0.931 1.000 1.000 443 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 FN3K(1), INPP1(1), INPP4B(1), INPP5A(1), INPP5B(2), INPPL1(1), ITPK1(2), ITPKA(1), PI4KA(3), PI4KB(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIP5K1A(1), PIP5K1B(1), PLCB1(4), PLCB2(1), PLCB3(1), PLCB4(3), PLCD3(1), PLCE1(4), PLCG1(2), PLCZ1(1), PTEN(8), SYNJ1(1), SYNJ2(1) 27582535 53 37 52 11 12 14 2 13 12 0 0.0452 1.000 1.000 444 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 IARS(1), IARS2(1), ILVBL(1), PDHA2(2), PDHB(1) 6800822 6 6 6 3 0 2 3 1 0 0 0.797 1.000 1.000 445 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 GBA(1), GNS(1), GUSB(2), HPSE2(3), IDUA(2), LCT(4), MAN2B2(1), MAN2C1(1), NAGLU(1), NEU3(2), SPAM1(2) 12929886 20 16 20 6 6 3 4 2 4 1 0.235 1.000 1.000 446 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 ALDOB(2), FPGT(2), GMDS(1), GMPPA(1), HK2(2), KHK(1), PFKFB1(1), PFKFB4(3), PFKP(1) 8874601 14 13 14 5 7 1 3 0 3 0 0.475 1.000 1.000 447 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(2), ANAPC2(2), ANAPC4(1), ANAPC5(1), BTRC(1), CUL1(3), CUL3(1), FZR1(2), SMURF2(1), UBA1(1), UBE2C(1), WWP1(2), WWP2(1) 15021301 19 16 19 5 5 3 2 7 2 0 0.367 1.000 1.000 448 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(1), CAMK2B(1), CAMK2G(1), CLCA1(1), CLCA2(1), CNGA3(4), CNGB1(1), GNAL(1), GUCA1C(1), PDE1C(4), PRKACA(2), PRKG1(1), PRKG2(1) 11239764 20 16 20 9 2 5 5 4 4 0 0.720 1.000 1.000 449 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA2C(1), CHRM1(1), CHRM2(1), CHRM4(1), CHRM5(1), DRD1(1), DRD2(1), DRD3(2), HTR1A(1), HTR1D(2), HTR2A(1), HTR4(1), HTR6(1) 9270164 15 13 15 6 3 6 4 2 0 0 0.334 1.000 1.000 450 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ACY1(1), AGMAT(1), ALDH18A1(1), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), AOC3(1), ARG2(2), CPS1(1), MAOB(1) 10880747 13 13 13 6 2 3 4 1 3 0 0.760 1.000 1.000 451 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 MAP2K3(2), MAP2K4(2), MAP2K6(2), MAP3K5(4), MAP3K7(1), MAPK1(1), MAPK11(1), NFKB1(1), SRF(1), TRAF6(2) 12584371 17 14 17 8 2 3 3 6 2 1 0.825 1.000 1.000 452 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(1), ACAT1(1), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), AOX1(2), BCKDHA(1), DBT(1), HMGCS1(1), HMGCS2(1), HSD17B4(1), MCCC1(1), MUT(2), OXCT2(1) 15951917 18 17 18 6 2 3 4 4 5 0 0.612 1.000 1.000 453 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 AKR1C3(1), ALOX12(2), ALOX15(1), ALOX5(1), CBR3(1), CYP4F2(2), EPX(2), GGT1(1), MPO(4), PLA2G4A(1), PTGIS(1), PTGS2(1), TBXAS1(1), TPO(1) 10609431 20 16 20 7 3 8 4 2 3 0 0.327 1.000 1.000 454 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS2(2), ADH4(2), ADH7(3), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), ALDOB(2), DLAT(1), ENO1(1), ENO2(2), G6PC2(1), GAPDH(1), HK2(2), LDHB(1), PDHA2(2), PDHB(1), PFKL(2), PFKP(1), PGK2(1), PGM1(1), PKLR(2) 21542974 33 26 33 9 5 5 9 5 9 0 0.328 1.000 1.000 455 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 EPO(1), PLCG1(2), STAT5A(1) 8127268 4 4 4 3 1 0 1 1 1 0 0.891 1.000 1.000 456 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(1), ALG11(1), ALG13(1), ALG2(1), ALG6(1), ALG9(1), DHDDS(1), FUT8(1), MAN1A1(3), MAN1B1(1), MAN1C1(2), MGAT3(1), MGAT5B(2), RPN2(2) 15753090 19 14 19 6 3 5 2 3 5 1 0.410 1.000 1.000 457 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 CHN1(1), LIMK1(2), MYLK(3), PAK1(1), PDGFRA(1), PIK3CA(6), PIK3R1(1), PLD1(2), PPP1R12B(1), RAC1(1), TRIO(2), VAV1(3) 12804766 24 19 23 8 5 3 6 7 3 0 0.577 1.000 1.000 458 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(1), GNAS(2), NFATC2(1), PLCG1(2), PPP3CC(2), PRKAR2B(1), PRKCA(1), SYT1(1) 12768406 11 11 11 6 2 1 2 2 4 0 0.928 1.000 1.000 459 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 18 IKBKAP(2), NFKB1(1), RELA(2), RIPK1(2), TRAF2(2) 8300241 9 9 9 5 1 5 1 1 1 0 0.796 1.000 1.000 460 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(2), LIPC(3), LPL(2), LRP1(4), SOAT1(1) 10019042 12 11 12 7 2 4 3 1 2 0 0.754 1.000 1.000 461 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOB(2), DLAT(1), ENO1(1), ENO2(2), GAPDH(1), HK2(2), LDHB(1), PDHA2(2), PDHB(1), PDHX(1), PFKL(2), PFKP(1), PGK2(1), PKLR(2), TNFAIP1(1) 15603326 21 18 21 5 4 3 5 4 5 0 0.298 1.000 1.000 462 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 99 CCL3(1), CD86(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA17(1), IFNA8(1), IFNAR1(1), IRF3(1), IRF5(1), LBP(1), MAP2K2(1), MAP2K3(2), MAP2K4(2), MAP2K6(2), MAP2K7(2), MAP3K7(1), MAPK1(1), MAPK10(2), MAPK11(1), NFKB1(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), RAC1(1), RELA(2), RIPK1(2), STAT1(2), TICAM1(2), TIRAP(1), TLR1(1), TLR2(3), TLR3(2), TLR4(1), TLR5(2), TLR8(1), TLR9(2), TNF(1), TRAF6(2) 32655030 63 43 62 12 11 15 11 16 10 0 0.0198 1.000 1.000 463 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOB(2), H6PD(2), PFKP(1), PGM1(1), TKT(1) 7396967 7 6 7 5 2 1 3 0 1 0 0.851 1.000 1.000 464 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), AOC3(1), ASPA(1), DDC(2), HDC(3), MAOB(1) 9047188 13 12 13 6 5 2 2 3 1 0 0.691 1.000 1.000 465 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTN1(1), BCAR1(1), BCR(2), CAPN1(1), CAPNS1(1), FYN(1), ITGA1(1), MAP2K2(1), MAPK1(1), PPP1R12B(1), PTK2(3), RAP1A(1), ROCK1(1), TLN1(2) 17678684 18 17 18 5 3 2 4 5 4 0 0.548 1.000 1.000 466 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG2(1), ADCY3(1), ADCY9(1), ATP6V0A4(1), ATP6V1A(2), ATP6V1E1(1), GNAS(2), PDIA4(1), PLCG1(2), PRKCA(1), SEC61A2(1), SEC61B(1) 13604814 15 13 15 6 2 4 2 4 3 0 0.735 1.000 1.000 467 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 ABAT(1), ADSL(1), AGXT2(1), ASNS(1), ASPA(1), DARS(1), GAD1(1), GAD2(2), GPT2(2) 9598797 11 9 11 7 2 4 1 3 1 0 0.856 1.000 1.000 468 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 BCR(2), BTK(1), CDKN2A(1), GAB1(1), ITPR1(4), ITPR2(6), ITPR3(2), LYN(1), PIK3CA(6), PPP1R13B(1), PREX1(2), PTEN(8), PTPRC(4), RPS6KA1(1), SAG(1), SYK(1), TEC(2), VAV1(3) 20679530 47 42 46 13 13 4 9 13 8 0 0.343 1.000 1.000 469 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 CDKN2A(1), ERBB4(4), GAB1(1), IGF1(1), INPPL1(1), IRS1(1), IRS4(3), MET(4), MYC(3), NOLC1(1), PAK1(1), PAK3(3), PAK4(1), PAK7(1), PIK3CA(6), PIK3CD(1), PPP1R13B(1), PREX1(2), PTEN(8), PTK2(3), RPS6KA1(1), SLC2A4(1), TSC1(1), TSC2(4), YWHAE(1) 28210022 55 45 54 13 10 12 7 14 12 0 0.188 1.000 1.000 470 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B10(1), G6PC2(1), GAA(1), GALK1(1), GLA(1), HK2(2), LCT(4), MGAM(5), PFKL(2), PFKP(1), PGM1(1), UGP2(1) 14371379 21 18 21 7 4 7 6 1 3 0 0.364 1.000 1.000 471 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 GTF2B(1), HDAC3(1), NCOA1(1), NCOR2(3), RARA(1), RXRA(1) 9270043 8 7 8 4 1 2 1 3 1 0 0.790 1.000 1.000 472 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ANGPTL2(2), ARHGEF11(1), BTK(1), GDI1(1), INPPL1(1), ITPR1(4), ITPR2(6), ITPR3(2), LIMK1(2), MYLK(3), MYLK2(2), PAK1(1), PAK3(3), PAK4(1), PAK7(1), PIK3CA(6), PIK3CD(1), PIK3CG(2), PIK3R1(1), PPP1R13B(1), PTEN(8), RHO(1), ROCK1(1), ROCK2(1), SAG(1) 25915311 54 42 53 13 10 11 9 15 9 0 0.168 1.000 1.000 473 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH4(2), ADH7(3), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), ALDOB(2), DLAT(1), ENO1(1), ENO2(2), GAPDH(1), HK2(2), LDHB(1), PDHA2(2), PDHB(1), PFKP(1), PGM1(1), PKLR(2) 18013698 27 21 27 9 5 5 6 5 6 0 0.553 1.000 1.000 474 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH4(2), ADH7(3), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), ALDOB(2), DLAT(1), ENO1(1), ENO2(2), GAPDH(1), HK2(2), LDHB(1), PDHA2(2), PDHB(1), PFKP(1), PGM1(1), PKLR(2) 18013698 27 21 27 9 5 5 6 5 6 0 0.553 1.000 1.000 475 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 GAS2(1), NFKB1(1), RELA(2), RIPK1(2), SPTAN1(3), TRAF2(2) 12305350 11 10 11 5 2 4 2 0 3 0 0.839 1.000 1.000 476 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B4GALT5(2), GALNT10(1), GALNT13(1), GALNT14(3), GALNT3(1), GALNT5(1), GALNT7(1), GALNT8(2), GALNTL5(1), OGT(1), ST6GALNAC1(1), WBSCR17(2) 11872599 17 11 17 9 2 9 3 1 2 0 0.680 1.000 1.000 477 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 DPYD(6), DTYMK(1), ENTPD1(1), NME2(1), NT5E(1), POLD1(2), POLE(5), POLG(1), POLQ(6), POLRMT(1), RRM2(1), TXNRD1(4), UMPS(1) 21268277 31 20 31 7 2 10 10 5 4 0 0.175 1.000 1.000 478 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(3), ATP5O(1), ATP6AP1(2), ATP6V0A4(1), ATP6V1A(2), ATP6V1E1(1), ATP7B(2), COX10(1), COX6A2(1), SDHA(1), UQCRB(1), UQCRC1(1) 14014550 17 16 17 6 2 2 9 2 2 0 0.636 1.000 1.000 479 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B10(1), ALDOB(2), FPGT(2), GMDS(1), GMPPA(1), HK2(2), KHK(1), LHPP(2), PFKFB1(1), PFKFB2(1), PFKFB4(3), PFKL(2), PFKP(1) 14012876 20 18 20 7 8 1 6 0 5 0 0.400 1.000 1.000 480 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(4), C5(2), C6(4), C7(1), IL1A(1), ITGA4(1), ITGB2(1), SELP(2), SELPLG(1), TNF(1), VCAM1(1) 9142773 19 18 19 8 3 2 6 7 1 0 0.708 1.000 1.000 481 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 70 ADH4(2), ADH7(3), AKR1C3(1), AKR1C4(1), ALDH1A3(2), CYP1A2(2), CYP2C18(3), CYP2C19(2), CYP2C9(2), CYP2E1(2), CYP2F1(2), CYP2S1(2), CYP3A4(2), CYP3A7(1), DHDH(1), EPHX1(1), GSTA4(1), GSTM5(1), UGT1A10(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT2A3(1), UGT2B11(3), UGT2B15(1), UGT2B17(2) 21281307 43 30 43 12 8 10 9 7 9 0 0.240 1.000 1.000 482 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 BRAF(1), DUSP9(1), MAP2K2(1), MAPK1(1), NFKB1(1), RAP1A(1), RPS6KA1(1) 10991541 7 7 7 7 1 3 1 1 1 0 0.975 1.000 1.000 483 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 APC(5), CAMP(1), EPHB2(1), ITPR1(4), ITPR2(6), ITPR3(2), KCNJ3(1), KCNJ5(2), MAPK1(1), RAC1(1), RHO(1), RYR1(15) 17015236 40 29 40 12 12 12 3 4 9 0 0.101 1.000 1.000 484 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 37 CCNH(1), GTF2B(1), GTF2H1(1), POLR3E(1), TAF6(1) 12777232 5 5 5 4 1 1 1 0 2 0 0.916 1.000 1.000 485 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 CREBBP(4), CTBP1(1), DLL3(1), DTX1(3), DTX2(3), DTX3(2), DTX4(1), DVL1(2), EP300(2), JAG1(4), JAG2(1), MAML1(1), MAML3(4), NCOR2(3), NCSTN(1), NOTCH1(1), NOTCH2(1), NOTCH3(3), NOTCH4(6), NUMBL(8), PSEN2(1), SNW1(2) 26590954 55 35 48 15 11 14 4 7 18 1 0.241 1.000 1.000 486 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(2), ACTN1(1), ANGPTL2(2), ARHGEF6(2), ARHGEF7(1), BCAR1(1), BRAF(1), CDKN2A(1), CSE1L(1), DOCK1(2), EPHB2(1), FYN(1), ITGA1(1), ITGA10(3), ITGA2(1), ITGA3(1), ITGA4(1), ITGA6(1), ITGA8(1), ITGA9(1), MAP2K4(2), MAP2K7(2), MAP3K11(1), MAPK1(1), MAPK10(2), MAPK8IP3(2), MYLK(3), MYLK2(2), PAK1(1), PAK3(3), PAK4(1), PAK7(1), PIK3CA(6), PIK3CB(1), PKLR(2), PLCG1(2), PTEN(8), PTK2(3), RHO(1), ROCK1(1), ROCK2(1), TLN1(2), TLN2(5), VASP(1) 45277232 80 59 79 16 14 17 12 22 15 0 0.0347 1.000 1.000 487 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 BTK(1), FCER1A(1), FYN(1), INPP5D(3), KRAS(2), LCP2(1), LYN(1), MAP2K2(1), MAP2K3(2), MAP2K4(2), MAP2K6(2), MAP2K7(2), MAPK1(1), MAPK10(2), MAPK11(1), MS4A2(3), NRAS(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PLA2G12B(1), PLA2G2D(1), PLA2G4A(1), PLCG1(2), PRKCA(1), PRKCE(2), RAC1(1), SYK(1), TNF(1), VAV1(3), VAV2(3), VAV3(1) 26747960 57 39 56 16 9 13 5 19 11 0 0.258 1.000 1.000 488 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(3), AGPAT6(2), CDIPT(1), CDS1(1), CHAT(1), DGKB(1), DGKD(2), DGKE(1), DGKG(3), DGKH(2), ESCO2(1), ETNK2(1), GPAM(1), GPD2(1), PLA2G12B(1), PLA2G2D(1), PLA2G4A(1), PLD1(2), PNPLA3(1), PPAP2A(1), PPAP2C(1), SH3GLB1(1) 24237423 30 23 29 9 8 7 6 4 5 0 0.347 1.000 1.000 489 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 GAA(1), GALK1(1), GLA(1), HK2(2), LCT(4), MGAM(5), PFKP(1), PGM1(1) 12056394 16 14 16 7 4 6 4 1 1 0 0.625 1.000 1.000 490 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACADL(1), ACADSB(1), ACAT1(1), ACSL3(1), ACSL4(2), ACSL6(3), ADH4(2), ADH7(3), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), CPT1A(1), CPT1B(1), CYP4A11(1), HSD17B4(1) 17981670 23 20 23 9 4 1 6 8 4 0 0.803 1.000 1.000 491 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(3), CDIPT(1), CDS1(1), CHAT(1), CPT1B(1), DGKB(1), DGKD(2), DGKE(1), DGKG(3), DGKH(2), GPD2(1), PAFAH2(2), PLA2G4A(1), PLCB2(1), PLCG1(2), PPAP2A(1), PPAP2C(1) 18686023 25 22 24 9 7 5 3 6 4 0 0.515 1.000 1.000 492 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 93 CARD11(3), CBLB(2), CBLC(1), CD3G(1), CD40LG(1), CDK4(1), CTLA4(1), FYN(1), GRAP2(2), IFNG(1), KRAS(2), LCK(1), LCP2(1), NCK2(1), NFAT5(4), NFATC2(1), NFKB1(1), NRAS(1), PAK1(1), PAK3(3), PAK4(1), PAK7(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PLCG1(2), PPP3CC(2), PRKCQ(2), PTPRC(4), TEC(2), TNF(1), VAV1(3), VAV2(3), VAV3(1), ZAP70(5) 37426911 69 46 68 14 11 17 14 14 13 0 0.0314 1.000 1.000 493 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ADH4(2), ADH7(3), ALDH1A3(2), AOC3(1), AOX1(2), DBH(1), DCT(2), DDC(2), ESCO2(1), HEMK1(1), HPD(1), MAOB(1), PNPLA3(1), PRMT2(2), PRMT3(1), PRMT6(1), PRMT8(1), SH3GLB1(1), TAT(2), TH(1), TPO(1), TYR(2), WBSCR22(1) 21733216 33 22 33 10 6 13 5 4 5 0 0.347 1.000 1.000 494 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 CISH(2), IARS(1), IL2RG(1), INPP5D(3), JAK1(1), JAK3(2), PI3(1), PIK3CA(6), PPP1R13B(1), SERPINA4(1) 13662869 19 16 18 8 3 4 4 7 1 0 0.802 1.000 1.000 495 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 BCAR1(1), CAPN1(1), CAPN11(2), CAPN3(1), CAPN5(1), CAPN7(2), CAPN9(2), CAPNS1(1), DOCK1(2), FYN(1), ITGA10(3), ITGA2(1), ITGA2B(2), ITGA3(1), ITGA4(1), ITGA6(1), ITGA8(1), ITGA9(1), ITGAD(3), ITGAE(1), ITGAM(2), ITGAV(3), ITGB2(1), ITGB4(2), ITGB6(1), ITGB7(2), ITGB8(1), MAP2K2(1), MAP2K3(2), MAP2K6(2), MAPK10(2), MAPK6(2), MAPK7(1), MYLK2(2), PAK1(1), PAK3(3), PAK4(1), PTK2(3), RAC1(1), RAPGEF1(1), RHO(1), ROCK1(1), ROCK2(1), SHC3(1), SORBS1(1), TLN1(2), TNS1(1), VASP(1), VAV2(3), VAV3(1) 50214439 76 51 76 15 13 22 15 15 11 0 0.00905 1.000 1.000 496 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 CASP4(2), CD40LG(1), FAS(1), NFKB1(1), NGFR(1), NTRK1(3), RIPK1(2), TNF(1), TNFRSF1A(1), TRAF2(2), TRAF6(2) 16085631 17 14 17 7 6 6 2 1 2 0 0.687 1.000 1.000 497 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ADORA3(2), ALG6(1), CCKBR(2), CCR3(1), CELSR1(6), CELSR2(2), CELSR3(3), CHRM2(1), CIDEB(1), EDNRA(1), EMR2(2), EMR3(1), F2R(1), GPR116(2), GPR132(1), GPR133(1), GPR135(1), GPR143(3), GPR55(1), GRM1(1), GRPR(1), LGR6(1), LPHN2(4), LPHN3(1), NTSR1(2), OR2M4(1), VN1R1(1) 24228063 45 33 45 12 10 13 8 11 3 0 0.0552 1.000 1.000 498 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 BRAF(1), CAB39(2), FIGF(1), IGF1(1), MAPK1(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PRKAA2(4), RICTOR(3), RPS6KA1(1), TSC1(1), TSC2(4), ULK1(2), ULK2(2), ULK3(1), VEGFC(1) 19864903 37 26 36 11 5 12 5 7 7 1 0.383 1.000 1.000 499 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(2), ABL2(1), BRAF(1), BTC(1), CAMK2B(1), CAMK2G(1), CBLB(2), CBLC(1), CDKN1A(2), EGF(4), EGFR(2), ERBB4(4), GAB1(1), KRAS(2), MAP2K2(1), MAP2K4(2), MAP2K7(2), MAPK1(1), MAPK10(2), MYC(3), NCK2(1), NRAS(1), NRG2(1), NRG3(1), PAK1(1), PAK3(3), PAK4(1), PAK7(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PLCG1(2), PRKCA(1), PRKCG(1), PTK2(3), SHC3(1), SHC4(2), STAT5A(1) 38209609 69 50 68 17 12 15 13 13 16 0 0.133 1.000 1.000 500 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 KDR(4), KRAS(2), MAP2K2(1), MAPK1(1), MAPK11(1), NFAT5(4), NFATC2(1), NOS3(2), NRAS(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PLA2G12B(1), PLA2G2D(1), PLA2G4A(1), PLCG1(2), PPP3CC(2), PRKCA(1), PRKCG(1), PTGS2(1), PTK2(3), RAC1(1), SPHK2(2) 26832461 45 37 44 13 5 5 11 12 12 0 0.500 1.000 1.000 501 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 63 BLNK(2), BTK(1), CARD11(3), CD22(1), CD81(1), CR2(2), FCGR2B(1), INPP5D(3), KRAS(2), LILRB3(1), LYN(1), NFAT5(4), NFATC2(1), NFKB1(1), NRAS(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PPP3CC(2), RAC1(1), SYK(1), VAV1(3), VAV2(3), VAV3(1) 27423399 48 32 47 13 6 13 10 8 11 0 0.226 1.000 1.000 502 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH4(2), ADH7(3), AGK(1), AGPAT6(2), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), CEL(3), DGKB(1), DGKD(2), DGKE(1), DGKG(3), DGKH(2), GK2(2), GLA(1), GPAM(1), LCT(4), LIPA(1), LIPC(3), LIPF(1), LPL(2), PNLIPRP1(1), PNPLA3(1), PPAP2A(1), PPAP2C(1) 21879405 44 33 43 14 5 9 12 9 9 0 0.508 1.000 1.000 503 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 85 BRAF(1), MAP2K2(1), MAP2K3(2), MAP2K4(2), MAP2K5(1), MAP2K6(2), MAP2K7(2), MAP3K11(1), MAP3K13(1), MAP3K5(4), MAP3K6(2), MAP3K7(1), MAP3K9(2), MAP4K1(3), MAP4K4(1), MAP4K5(1), MAPK1(1), MAPK10(2), MAPK11(1), MAPK6(2), MAPK7(1), MEF2B(2), MEF2C(1), MYC(3), NFKB1(1), PAK1(1), RAC1(1), RELA(2), RIPK1(2), RPS6KA1(1), SP1(2), STAT1(2), TGFB1(1), TGFBR1(1), TRAF2(2) 36339251 56 35 56 13 9 18 9 12 8 0 0.0499 1.000 1.000 504 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 109 ACTN1(1), ACTN4(3), ARHGAP5(1), BCAR1(1), CDH5(1), CLDN1(1), CLDN10(1), CLDN15(1), CLDN2(1), CLDN4(1), CLDN6(1), CLDN8(1), CTNNA1(2), CTNNA2(5), CTNNA3(3), CTNND1(3), CYBB(1), EZR(1), F11R(4), ITGA4(1), ITGAM(2), ITGB2(1), MAPK11(1), MLLT4(1), MMP9(1), NCF4(1), NOX1(1), OCLN(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PLCG1(2), PRKCA(1), PRKCG(1), PTK2(3), PTK2B(2), PTPN11(3), RAC1(1), RAP1A(1), RAPGEF4(1), ROCK1(1), ROCK2(1), SIPA1(1), TXK(1), VASP(1), VAV1(3), VAV2(3), VAV3(1), VCAM1(1) 46132761 83 52 82 18 14 20 14 21 14 0 0.0214 1.000 1.000 505 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 50 AKR1C3(1), ALOX12(2), ALOX12B(3), ALOX15(1), ALOX15B(1), ALOX5(1), CBR3(1), CYP2C18(3), CYP2C19(2), CYP2C9(2), CYP2E1(2), CYP2J2(2), CYP4A11(1), CYP4F2(2), GGT1(1), GPX5(2), PLA2G12B(1), PLA2G2D(1), PLA2G4A(1), PTGIS(1), PTGS2(1), TBXAS1(1) 14887032 33 27 33 11 6 7 12 3 5 0 0.418 1.000 1.000 506 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AMY2B(4), ENPP3(2), GAA(1), GBE1(4), GUSB(2), GYS2(1), HK2(2), MGAM(5), PGM1(1), PYGB(1), PYGM(2), RNPC3(1), SI(4), UGDH(1), UGT1A10(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT2B15(1) 21353980 37 26 37 10 10 13 3 5 6 0 0.164 1.000 1.000 507 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 89 ACVR1B(1), ACVR2B(1), AMHR2(1), BMP5(1), BMP6(2), BMPR2(1), CHRD(2), COMP(2), CREBBP(4), CUL1(3), E2F4(2), EP300(2), FST(1), ID3(1), ID4(1), IFNG(1), INHBA(1), LTBP1(4), MAPK1(1), MYC(3), PPP2R1A(1), PPP2R1B(1), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), ROCK1(1), ROCK2(1), SMAD3(1), SMURF2(1), SP1(2), TFDP1(1), TGFB1(1), TGFBR1(1), TGFBR2(1), THBS1(1), THBS3(2), TNF(1), ZFYVE9(4) 36197643 58 37 58 16 10 13 9 13 13 0 0.272 1.000 1.000 508 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 84 ANPEP(1), CD1A(1), CD1C(1), CD22(1), CD33(1), CD34(1), CD3G(1), CR1(3), CR2(2), CSF1R(2), CSF2RA(1), CSF3R(1), EPO(1), FCER2(2), HLA-DRB1(1), HLA-DRB5(1), IL1A(1), IL5RA(2), IL6R(1), IL7R(1), IL9R(2), ITGA1(1), ITGA2(1), ITGA2B(2), ITGA3(1), ITGA4(1), ITGA6(1), ITGAM(2), KIT(4), MME(2), MS4A1(1), TNF(1), TPO(1) 30408193 46 30 46 13 6 12 11 7 9 1 0.275 1.000 1.000 509 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 BRAF(1), CD48(1), FAS(1), FCGR3A(2), FYN(1), HLA-E(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA17(1), IFNA8(1), IFNAR1(1), IFNG(1), ITGB2(1), KIR3DL1(2), KIR3DL2(1), KLRC3(1), KRAS(2), LCK(1), LCP2(1), MAP2K2(1), MAPK1(1), MICA(1), NFAT5(4), NFATC2(1), NRAS(1), PAK1(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PLCG1(2), PPP3CC(2), PRKCA(1), PRKCG(1), PTK2B(2), PTPN11(3), RAC1(1), SHC3(1), SHC4(2), SYK(1), TNF(1), TNFRSF10D(1), ULBP1(1), VAV1(3), VAV2(3), VAV3(1), ZAP70(5) 41909183 76 53 75 21 12 20 10 19 15 0 0.183 1.000 1.000 510 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CDIPT(1), CDS1(1), DGKB(1), DGKD(2), DGKE(1), DGKG(3), DGKH(2), FN3K(1), INPP1(1), INPP4B(1), INPP5A(1), INPP5B(2), INPP5D(3), INPPL1(1), ITPK1(2), ITPKA(1), ITPR1(4), ITPR2(6), ITPR3(2), PI4KA(3), PI4KB(1), PIK3C2G(7), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PIP5K1A(1), PIP5K1B(1), PLCB1(4), PLCB2(1), PLCB3(1), PLCB4(3), PLCD3(1), PLCE1(4), PLCG1(2), PLCZ1(1), PRKCA(1), PRKCG(1), PTEN(8), SYNJ1(1), SYNJ2(1) 46731979 90 59 88 24 18 22 10 21 19 0 0.114 1.000 1.000 511 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 152 CBLB(2), CBLC(1), CCND1(1), CISH(2), CNTFR(1), CREBBP(4), CSF2RA(1), CSF2RB(2), CSF3R(1), EP300(2), EPO(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA17(1), IFNA8(1), IFNAR1(1), IFNG(1), IFNW1(2), IL10RA(2), IL12RB1(1), IL12RB2(3), IL13RA2(1), IL20RA(1), IL21R(1), IL22RA1(1), IL23A(1), IL23R(1), IL26(1), IL2RB(4), IL2RG(1), IL5RA(2), IL6R(1), IL7R(1), IL9R(2), IRF9(1), JAK1(1), JAK3(2), LIFR(1), MYC(3), PIAS1(2), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PIM1(1), PRLR(4), PTPN11(3), SOCS2(1), SPRED1(2), SPRED2(1), SPRY3(2), STAT1(2), STAT4(1), STAT5A(1), TPO(1) 53770951 92 56 91 22 14 24 18 21 15 0 0.0662 1.000 1.000 512 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP5(1), BMP6(2), BTRC(1), CSNK1G3(1), GLI1(4), GLI2(1), GLI3(1), HHIP(2), LRP2(12), PRKACA(2), PTCH1(1), PTCH2(1), STK36(1), SUFU(2), WNT10B(1), WNT2(1), WNT5A(1), WNT7B(1), WNT8A(1), WNT8B(1), ZIC2(1) 22010247 39 30 39 13 5 8 8 11 7 0 0.378 1.000 1.000 513 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AMY2B(4), ASCC3(2), ATP13A2(1), DDX18(2), DDX4(1), DDX41(1), DDX50(1), DDX51(1), DDX52(1), DDX56(1), ENPP3(2), EP400(2), G6PC2(1), GAA(1), GBA(1), GBE1(4), GUSB(2), GYS2(1), HK2(2), IFIH1(1), MGAM(5), MOV10L1(1), PGM1(1), PYGB(1), PYGM(2), RAD54B(1), RAD54L(1), RUVBL2(2), SETX(3), SI(4), SMARCA2(2), SMARCA5(2), UGDH(1), UGP2(1), UGT1A10(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT2A3(1), UGT2B11(3), UGT2B15(1), UGT2B17(2) 46113506 71 49 71 16 15 23 12 10 11 0 0.0295 1.000 1.000 514 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACTB(1), ACTN1(1), ACTN4(3), ACVR1B(1), BAIAP2(2), CREBBP(4), CTNNA1(2), CTNNA2(5), CTNNA3(3), CTNND1(3), EGFR(2), EP300(2), FARP2(1), FER(1), FGFR1(3), FYN(1), IGF1R(1), IQGAP1(4), LMO7(3), MAP3K7(1), MAPK1(1), MET(4), MLLT4(1), PTPRB(4), PTPRF(2), PTPRJ(1), PTPRM(4), PVRL2(1), PVRL3(2), RAC1(1), SMAD3(1), SNAI1(1), SORBS1(1), SSX2IP(1), TCF7L1(1), TCF7L2(1), TGFBR1(1), TGFBR2(1), TJP1(1), WASF3(2), YES1(1) 44285300 77 45 77 20 10 31 13 12 11 0 0.0467 1.000 1.000 515 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 248 ACVR1B(1), ARRB1(1), BRAF(1), CACNA1A(7), CACNA1B(4), CACNA1C(4), CACNA1D(2), CACNA1E(4), CACNA1F(5), CACNA1G(3), CACNA1H(4), CACNA1I(3), CACNA1S(5), CACNA2D1(2), CACNA2D3(1), CACNA2D4(1), CACNB1(1), CACNB2(1), CACNB4(1), CACNG3(2), CACNG5(2), CACNG6(1), CACNG8(1), CDC25B(1), DUSP5(1), DUSP7(2), DUSP9(1), EGF(4), EGFR(2), FAS(1), FGF13(3), FGF17(1), FGF18(1), FGF23(1), FGF3(2), FGFR1(3), FGFR3(1), FGFR4(2), FLNA(4), FLNB(2), FLNC(3), IL1A(1), KRAS(2), MAP2K2(1), MAP2K3(2), MAP2K4(2), MAP2K5(1), MAP2K6(2), MAP2K7(2), MAP3K13(1), MAP3K5(4), MAP3K6(2), MAP3K7(1), MAP4K1(3), MAP4K4(1), MAPK1(1), MAPK10(2), MAPK11(1), MAPK7(1), MAPK8IP3(2), MAPT(1), MEF2C(1), MYC(3), NF1(10), NFATC2(1), NFKB1(1), NRAS(1), NTRK1(3), NTRK2(2), PAK1(1), PDGFB(1), PDGFRA(1), PDGFRB(2), PLA2G12B(1), PLA2G2D(1), PLA2G4A(1), PPP3CC(2), PPP5C(1), PRKACA(2), PRKCA(1), PRKCG(1), PTPN5(2), PTPN7(1), PTPRR(2), RAC1(1), RAP1A(1), RAPGEF2(1), RASA1(2), RASGRF1(4), RASGRF2(2), RPS6KA1(1), RRAS(1), SRF(1), TAOK1(2), TAOK2(1), TGFB1(1), TGFBR1(1), TGFBR2(1), TNF(1), TNFRSF1A(1), TP53(90), TRAF2(2), TRAF6(2), ZAK(1) 109443143 284 145 268 76 48 63 45 50 77 1 0.00756 1.000 1.000 516 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTB(1), ACTN1(1), ACTN4(3), ARHGAP5(1), BCAR1(1), BRAF(1), CCND1(1), CHAD(1), COL11A1(3), COL11A2(7), COL1A1(2), COL1A2(1), COL4A1(5), COL4A2(2), COL4A4(4), COL4A6(4), COL5A2(1), COL5A3(9), COL6A1(2), COL6A3(4), COL6A6(3), COMP(2), DIAPH1(2), DOCK1(2), EGF(4), EGFR(2), FARP2(1), FIGF(1), FLNA(4), FLNB(2), FLNC(3), FLT1(1), FN1(3), FYN(1), HGF(1), IGF1(1), IGF1R(1), ITGA1(1), ITGA10(3), ITGA2(1), ITGA2B(2), ITGA3(1), ITGA4(1), ITGA6(1), ITGA8(1), ITGA9(1), ITGAV(3), ITGB4(2), ITGB6(1), ITGB7(2), ITGB8(1), KDR(4), LAMA1(4), LAMA2(5), LAMA3(4), LAMA4(2), LAMA5(5), LAMB1(2), LAMB2(1), LAMB3(2), LAMB4(1), LAMC1(3), LAMC2(1), LAMC3(2), MAPK1(1), MAPK10(2), MET(4), MYLK(3), MYLK2(2), PAK1(1), PAK3(3), PAK4(1), PAK7(1), PARVG(1), PDGFB(1), PDGFD(1), PDGFRA(1), PDGFRB(2), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PPP1R12A(1), PRKCA(1), PRKCG(1), PTEN(8), PTK2(3), RAC1(1), RAP1A(1), RAPGEF1(1), RELN(6), ROCK1(1), ROCK2(1), SHC3(1), SHC4(2), THBS1(1), THBS3(2), TLN1(2), TLN2(5), TNC(4), TNN(2), TNR(7), TNXB(6), VASP(1), VAV1(3), VAV2(3), VAV3(1), VEGFC(1), VTN(2), VWF(4) 138491002 253 123 252 73 39 80 38 55 40 1 0.0121 1.000 1.000 517 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(1), ADCY2(2), ADCY3(1), ADCY7(1), ADCY8(2), ADCY9(1), ADORA2A(1), AGTR1(1), ATP2A1(1), ATP2A2(1), ATP2A3(2), ATP2B1(3), ATP2B2(2), ATP2B4(1), BDKRB1(1), BST1(2), CACNA1A(7), CACNA1B(4), CACNA1C(4), CACNA1D(2), CACNA1E(4), CACNA1F(5), CACNA1G(3), CACNA1H(4), CACNA1I(3), CACNA1S(5), CAMK2B(1), CAMK2G(1), CCKAR(1), CCKBR(2), CHRM1(1), CHRM2(1), CHRM5(1), CHRNA7(1), CYSLTR2(2), DRD1(1), EDNRA(1), EGFR(2), ERBB4(4), F2R(1), GNA11(1), GNAL(1), GNAS(2), GRIN1(2), GRIN2A(2), GRIN2D(1), GRM1(1), GRM5(4), GRPR(1), HTR2A(1), HTR4(1), HTR6(1), ITPKA(1), ITPR1(4), ITPR2(6), ITPR3(2), LHCGR(5), MYLK(3), MYLK2(2), NOS1(6), NOS3(2), NTSR1(2), P2RX7(1), PDE1A(2), PDE1B(2), PDE1C(4), PDGFRA(1), PDGFRB(2), PHKA1(3), PHKA2(2), PHKB(2), PLCB1(4), PLCB2(1), PLCB3(1), PLCB4(3), PLCD3(1), PLCE1(4), PLCG1(2), PLCZ1(1), PPP3CC(2), PRKACA(2), PRKCA(1), PRKCG(1), PTAFR(1), PTK2B(2), RYR1(15), RYR2(15), RYR3(6), SLC8A1(2), SLC8A2(2), SLC8A3(5), SPHK2(2), TACR1(2), TRHR(1), TRPC1(1), VDAC1(1) 102378844 232 114 230 83 51 64 40 35 41 1 0.0551 1.000 1.000 518 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(1), CHAD(1), COL11A1(3), COL11A2(7), COL17A1(3), COL1A1(2), COL1A2(1), COL4A1(5), COL4A2(2), COL4A4(4), COL4A6(4), COL5A2(1), COL5A3(9), COL6A1(2), COL6A3(4), COL6A6(3), COMP(2), DSC3(1), DSG2(2), DSG3(1), DSG4(2), FN1(3), GJA4(1), GJA5(1), GJA8(1), GJB1(1), GJB2(1), GJD2(2), INA(1), ITGA6(1), ITGB4(2), KRT1(1), KRT10(2), KRT12(1), KRT14(3), KRT16(1), KRT18(1), KRT20(1), KRT23(1), KRT27(1), KRT33B(1), KRT36(1), KRT4(3), KRT5(3), KRT6A(1), KRT6B(1), KRT6C(1), KRT71(1), KRT72(1), KRT73(1), KRT74(1), KRT75(2), KRT76(1), KRT77(2), KRT78(1), KRT79(1), KRT8(1), KRT81(1), KRT82(1), KRT84(1), KRT85(1), KRT86(1), LAMA1(4), LAMA2(5), LAMA3(4), LAMA4(2), LAMA5(5), LAMB1(2), LAMB2(1), LAMB3(2), LAMB4(1), LAMC1(3), LAMC2(1), LAMC3(2), LMNB1(1), NES(2), RELN(6), THBS1(1), THBS3(2), TNC(4), TNN(2), TNR(7), TNXB(6), VTN(2), VWF(4) 92753951 183 92 183 63 37 65 21 31 27 2 0.0888 1.000 1.000 519 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 237 ADORA2A(1), ADORA3(2), ADRA2B(1), ADRA2C(1), AGTR1(1), AGTR2(1), BDKRB1(1), C3AR1(1), CALCR(3), CALCRL(1), CCKAR(1), CCKBR(2), CHRM1(1), CHRM2(1), CHRM4(1), CHRM5(1), CNR1(3), CRHR2(4), CTSG(1), CYSLTR2(2), DRD1(1), DRD2(1), DRD3(2), EDNRA(1), F2R(1), GABRA1(1), GABRA2(2), GABRA4(1), GABRA5(2), GABRA6(2), GABRB2(1), GABRD(1), GABRE(1), GABRG1(2), GABRG3(1), GABRP(1), GABRR1(5), GHSR(2), GLP1R(2), GLP2R(2), GLRA1(3), GLRA3(2), GPR156(3), GPR50(2), GPR63(1), GRIA1(6), GRIA4(1), GRID1(1), GRID2(3), GRIK1(2), GRIK2(1), GRIK3(4), GRIK4(2), GRIK5(2), GRIN1(2), GRIN2A(2), GRIN2D(1), GRIN3A(4), GRIN3B(1), GRM1(1), GRM3(5), GRM4(1), GRM5(4), GRM7(2), GRM8(2), GRPR(1), HCRTR2(1), HRH3(1), HTR1A(1), HTR1D(2), HTR2A(1), HTR4(1), HTR6(1), LHCGR(5), MTNR1A(1), NMUR2(2), NPBWR2(1), NPFFR2(1), NTSR1(2), OPRM1(1), P2RX7(1), P2RY10(1), P2RY2(1), P2RY4(1), P2RY6(1), PRLHR(4), PRLR(4), PRSS1(1), PTAFR(1), PTGER2(2), PTGIR(1), PTH2R(2), RXFP1(1), RXFP2(3), SCTR(3), SSTR3(1), TAAR2(1), TAAR6(1), TACR1(2), THRA(1), TRHR(1), VIPR1(2) 80343925 178 92 177 61 39 49 36 34 20 0 0.0527 1.000 1.000 520 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 202 ACTN1(1), ACTN4(3), APC(5), ARHGEF1(1), ARHGEF4(1), ARHGEF6(2), ARHGEF7(1), ARPC1B(1), BAIAP2(2), BCAR1(1), BDKRB1(1), BRAF(1), CHRM1(1), CHRM2(1), CHRM4(1), CHRM5(1), CYFIP1(1), CYFIP2(3), DIAPH1(2), DIAPH2(3), DOCK1(2), EGF(4), EGFR(2), EZR(1), F2R(1), FGD3(1), FGF13(3), FGF17(1), FGF18(1), FGF23(1), FGF3(2), FGFR1(3), FGFR3(1), FGFR4(2), FN1(3), IQGAP1(4), IQGAP3(2), ITGA1(1), ITGA10(3), ITGA2(1), ITGA2B(2), ITGA3(1), ITGA4(1), ITGA6(1), ITGA8(1), ITGA9(1), ITGAD(3), ITGAE(1), ITGAM(2), ITGAV(3), ITGB2(1), ITGB4(2), ITGB6(1), ITGB7(2), ITGB8(1), KRAS(2), LIMK1(2), MAP2K2(1), MAPK1(1), MYH10(3), MYH14(4), MYH9(3), MYLK(3), MYLK2(2), NCKAP1(2), NCKAP1L(1), NRAS(1), PAK1(1), PAK3(3), PAK4(1), PAK7(1), PDGFB(1), PDGFRA(1), PDGFRB(2), PFN2(1), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PIP5K1A(1), PIP5K1B(1), PPP1R12A(1), PPP1R12B(1), PTK2(3), RAC1(1), RDX(1), ROCK1(1), ROCK2(1), RRAS(1), SCIN(1), SSH1(2), SSH3(2), TIAM1(1), VAV1(3), VAV2(3), VAV3(1) 103506601 168 91 167 46 27 47 35 29 30 0 0.0263 1.000 1.000 521 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 130 ACTB(1), ACTN1(1), ACTN4(3), ASH1L(2), CDK4(1), CGN(1), CLDN1(1), CLDN10(1), CLDN15(1), CLDN2(1), CLDN4(1), CLDN6(1), CLDN8(1), CTNNA1(2), CTNNA2(5), CTNNA3(3), CTTN(3), EPB41(1), EPB41L1(1), EPB41L3(1), F11R(4), HCLS1(2), KRAS(2), LLGL2(1), MAGI1(3), MAGI2(3), MAGI3(1), MLLT4(1), MPDZ(2), MYH1(4), MYH10(3), MYH11(4), MYH13(2), MYH14(4), MYH15(3), MYH2(6), MYH3(4), MYH4(6), MYH6(1), MYH7(7), MYH7B(4), MYH9(3), NRAS(1), OCLN(1), PARD6B(1), PPP2R1A(1), PPP2R1B(1), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), PPP2R3A(1), PPP2R3B(1), PRKCA(1), PRKCE(2), PRKCG(1), PRKCH(1), PRKCI(1), PRKCQ(2), PTEN(8), RRAS(1), SPTAN1(3), SYMPK(1), TJAP1(1), TJP1(1), TJP2(4), TJP3(2), YES1(1), ZAK(1) 72317177 143 89 143 40 23 31 34 26 29 0 0.155 1.000 1.000 522 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(2), DCC(7), DPYSL5(2), EFNB3(1), EPHA1(1), EPHA2(1), EPHA3(3), EPHA4(2), EPHA5(4), EPHA6(3), EPHA7(3), EPHA8(4), EPHB1(2), EPHB2(1), EPHB4(1), EPHB6(1), FES(1), FYN(1), KRAS(2), L1CAM(1), LIMK1(2), LRRC4C(1), MAPK1(1), MET(4), NCK2(1), NFAT5(4), NFATC2(1), NRAS(1), NTN1(1), NTN4(1), PAK1(1), PAK3(3), PAK4(1), PAK7(1), PLXNA1(2), PLXNA2(3), PLXNA3(1), PLXNB1(2), PLXNB2(1), PLXNB3(2), PPP3CC(2), PTK2(3), RAC1(1), RASA1(2), ROBO2(3), ROBO3(3), ROCK1(1), ROCK2(1), SEMA3A(2), SEMA3C(1), SEMA3D(1), SEMA4B(1), SEMA4D(2), SEMA5A(2), SEMA5B(1), SEMA6A(2), SEMA6B(1), SEMA6D(3), SLIT2(4), SLIT3(3), SRGAP1(3), SRGAP3(3), UNC5A(2), UNC5B(3), UNC5C(1), UNC5D(1) 72682540 129 85 129 46 22 30 37 24 16 0 0.469 1.000 1.000 523 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(1), CHAD(1), COL11A1(3), COL11A2(7), COL1A1(2), COL1A2(1), COL4A1(5), COL4A2(2), COL4A4(4), COL4A6(4), COL5A2(1), COL5A3(9), COL6A1(2), COL6A3(4), COL6A6(3), FN1(3), GP6(1), HMMR(1), HSPG2(4), ITGA1(1), ITGA10(3), ITGA2(1), ITGA2B(2), ITGA3(1), ITGA4(1), ITGA6(1), ITGA8(1), ITGA9(1), ITGAV(3), ITGB4(2), ITGB6(1), ITGB7(2), ITGB8(1), LAMA1(4), LAMA2(5), LAMA3(4), LAMA4(2), LAMA5(5), LAMB1(2), LAMB2(1), LAMB3(2), LAMB4(1), LAMC1(3), LAMC2(1), LAMC3(2), RELN(6), SV2A(1), SV2B(2), SV2C(3), THBS1(1), THBS3(2), TNC(4), TNN(2), TNR(7), TNXB(6), VTN(2), VWF(4) 83847342 151 83 151 50 27 45 25 28 25 1 0.185 1.000 1.000 524 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(1), ADCY2(2), ADCY3(1), ADCY5(1), ADCY7(1), ADCY8(2), ADCY9(1), ANXA6(1), ARRB1(1), ATP1A4(3), ATP1B2(1), ATP2A2(1), ATP2A3(2), ATP2B1(3), ATP2B2(2), CACNA1A(7), CACNA1B(4), CACNA1C(4), CACNA1D(2), CACNA1E(4), CACNA1S(5), CACNB1(1), CAMK2B(1), CAMK2G(1), CHRM1(1), CHRM2(1), CHRM4(1), CHRM5(1), GJA4(1), GJA5(1), GJB1(1), GJB2(1), GNA11(1), GNAZ(1), GNB2(1), GRK4(1), GRK5(1), ITPR1(4), ITPR2(6), ITPR3(2), KCNB1(1), KCNJ3(1), KCNJ5(2), PKIB(1), PLCB3(1), PRKACA(2), PRKAR2B(1), PRKCA(1), PRKCE(2), PRKCG(1), PRKCH(1), PRKCQ(2), PRKD1(1), RGS11(1), RGS17(1), RGS18(1), RGS2(1), RGS6(1), RGS7(2), RYR1(15), RYR2(15), RYR3(6), SLC8A1(2), SLC8A3(5) 71407703 144 75 143 58 28 45 27 18 26 0 0.244 1.000 1.000 525 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 251 ACVR1B(1), ACVR2B(1), AMHR2(1), BMPR2(1), CCL15(1), CCL23(1), CCL3(1), CCR1(1), CCR3(1), CCR4(1), CD40LG(1), CNTFR(1), CSF1R(2), CSF2RA(1), CSF2RB(2), CSF3R(1), CX3CL1(2), CXCL14(2), CXCL5(1), CXCR6(2), EDA2R(1), EGF(4), EGFR(2), EPO(1), FAS(1), FLT1(1), FLT4(2), HGF(1), IFNA1(1), IFNA14(1), IFNA16(1), IFNA17(1), IFNA8(1), IFNAR1(1), IFNG(1), IFNW1(2), IL10RA(2), IL12RB1(1), IL12RB2(3), IL17A(1), IL17B(1), IL17RA(2), IL18R1(1), IL1A(1), IL20RA(1), IL21R(1), IL22RA1(1), IL23A(1), IL23R(1), IL25(1), IL26(1), IL2RB(4), IL2RG(1), IL5RA(2), IL6R(1), IL7R(1), IL9R(2), INHBA(1), KDR(4), KIT(4), LIFR(1), MET(4), NGFR(1), PDGFB(1), PDGFRA(1), PDGFRB(2), PLEKHO2(1), PRLR(4), TGFB1(1), TGFBR1(1), TGFBR2(1), TNF(1), TNFRSF10D(1), TNFRSF19(1), TNFRSF1A(1), TNFRSF21(3), TNFRSF8(1), TNFRSF9(2), TNFSF15(1), TPO(1), VEGFC(1) 65830818 117 68 117 33 23 33 20 22 18 1 0.0353 1.000 1.000 526 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 131 ACACA(1), ACACB(2), BRAF(1), CBLB(2), CBLC(1), EXOC7(1), FASN(3), G6PC2(1), GYS2(1), INPP5D(3), IRS1(1), IRS4(3), KRAS(2), MAP2K2(1), MAPK1(1), MAPK10(2), NRAS(1), PDE3A(1), PDE3B(3), PFKL(2), PFKP(1), PHKA1(3), PHKA2(2), PHKB(2), PIK3CA(6), PIK3CB(1), PIK3CD(1), PIK3CG(2), PIK3R1(1), PIK3R3(1), PKLR(2), PPARGC1A(1), PPP1R3A(5), PRKAA2(4), PRKAB2(1), PRKACA(2), PRKAR2B(1), PRKCI(1), PTPRF(2), PYGB(1), PYGM(2), RAPGEF1(1), SHC3(1), SHC4(2), SLC2A4(1), SOCS2(1), SORBS1(1), SREBF1(2), TRIP10(1), TSC1(1), TSC2(4) 59646946 90 68 89 29 7 22 19 26 16 0 0.407 1.000 1.000 527 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA2(2), ADCY1(1), ADCY2(2), ADCY3(1), ADCY5(1), ADCY7(1), ADCY8(2), ADCY9(1), ARRB1(1), ATP2A2(1), ATP2A3(2), CAMK2B(1), CAMK2G(1), CNN1(1), CNN2(1), CORIN(1), GBA2(3), GNB2(1), GRK4(1), GRK5(1), GUCY1A3(1), IGFBP4(1), ITPR1(4), ITPR2(6), ITPR3(2), MYLK2(2), NFKB1(1), NOS1(6), NOS3(2), PDE4B(1), PDE4D(2), PKIB(1), PLCB3(1), PLCG1(2), PRKACA(2), PRKAR2B(1), PRKCA(1), PRKCE(2), PRKCH(1), PRKCQ(2), PRKD1(1), RGS11(1), RGS17(1), RGS18(1), RGS2(1), RGS6(1), RGS7(2), RLN1(1), RYR1(15), RYR2(15), RYR3(6), SLC8A1(2), SP1(2), TNXB(6) 65525642 122 68 122 52 22 40 25 15 20 0 0.440 1.000 1.000 528 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 BRAF(1), CACNA1A(7), GNA11(1), GNAS(2), GNAZ(1), GRIA1(6), GRID2(3), GRM1(1), GRM5(4), GUCY1A3(1), GUCY1B3(2), GUCY2C(2), IGF1(1), IGF1R(1), ITPR1(4), ITPR2(6), ITPR3(2), KRAS(2), LYN(1), MAP2K2(1), MAPK1(1), NOS1(6), NOS3(2), NPR2(1), NRAS(1), PLA2G12B(1), PLA2G2D(1), PLA2G4A(1), PLCB1(4), PLCB2(1), PLCB3(1), PLCB4(3), PPP2R1A(1), PPP2R1B(1), PPP2R2A(1), PPP2R2B(1), PPP2R2C(1), PRKCA(1), PRKCG(1), PRKG1(1), PRKG2(1), RYR1(15) 41532840 96 63 95 32 23 26 16 14 17 0 0.150 1.000 1.000 529 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 129 CD22(1), CD276(1), CD34(1), CD40LG(1), CD58(1), CD86(1), CDH15(1), CDH3(1), CDH4(3), CDH5(1), CLDN1(1), CLDN10(1), CLDN15(1), CLDN2(1), CLDN4(1), CLDN6(1), CLDN8(1), CNTN2(1), CTLA4(1), F11R(4), HLA-DOA(1), HLA-DOB(1), HLA-DQA2(2), HLA-DRB1(1), HLA-DRB5(1), HLA-E(1), HLA-F(1), ITGA4(1), ITGA6(1), ITGA8(1), ITGA9(1), ITGAM(2), ITGAV(3), ITGB2(1), ITGB7(2), ITGB8(1), L1CAM(1), MADCAM1(1), MAG(2), NCAM1(1), NCAM2(2), NEGR1(2), NFASC(1), NLGN1(1), NLGN2(1), NLGN3(1), NRCAM(1), NRXN1(5), NRXN2(2), NRXN3(2), OCLN(1), PTPRC(4), PTPRF(2), PTPRM(4), PVRL2(1), PVRL3(2), SELL(1), SELP(2), SELPLG(1), SIGLEC1(1), SPN(1), VCAM1(1) 54211150 90 61 90 30 17 27 20 21 5 0 0.162 1.000 1.000 530 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADORA2A(1), ADORA3(2), ADRA2C(1), AGTR1(1), AGTR2(1), BDKRB1(1), C3AR1(1), CCKAR(1), CCKBR(2), CCR1(1), CCR3(1), CCR4(1), CHRM1(1), CHRM2(1), CHRM4(1), CHRM5(1), CMKLR1(1), CNR1(3), DRD1(1), DRD2(1), DRD3(2), EDNRA(1), F2R(1), GHSR(2), GPR37(2), GPR37L1(1), GPR50(2), GPR63(1), GRPR(1), HCRTR2(1), HRH3(1), HTR1A(1), HTR1D(2), HTR2A(1), HTR4(1), HTR6(1), LHCGR(5), MTNR1A(1), NMUR2(2), NTSR1(2), OPN1SW(1), OPRM1(1), OR10A5(1), OR11A1(2), OR1C1(2), OR1F1(1), OR2H1(2), OR5V1(3), OR7A5(1), OR7C1(1), OR8B8(1), P2RY10(1), P2RY12(1), P2RY2(1), P2RY6(1), PTAFR(1), PTGER2(2), PTGIR(1), RGR(1), RHO(1), SSTR3(1), SUCNR1(1), TRHR(1) 43013389 84 58 83 36 14 23 21 14 12 0 0.504 1.000 1.000 531 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(1), ADCY2(2), ADCY3(1), ADCY5(1), ADCY7(1), ADCY8(2), ADCY9(1), DRD1(1), DRD2(1), EGF(4), EGFR(2), GJD2(2), GNA11(1), GNAS(2), GRM1(1), GRM5(4), GUCY1A3(1), GUCY1B3(2), GUCY2C(2), HTR2A(1), ITPR1(4), ITPR2(6), ITPR3(2), KRAS(2), MAP2K2(1), MAP2K5(1), MAPK1(1), MAPK7(1), NPR2(1), NRAS(1), PDGFB(1), PDGFD(1), PDGFRA(1), PDGFRB(2), PLCB1(4), PLCB2(1), PLCB3(1), PLCB4(3), PRKACA(2), PRKCA(1), PRKCG(1), PRKG1(1), PRKG2(1), TJP1(1), TUBA3C(3), TUBA3E(1), TUBA4A(1), TUBA8(1), TUBAL3(2), TUBB2B(2), TUBB8(3) 49108820 87 54 86 40 18 26 14 20 9 0 0.724 1.000 1.000 532 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(3), BDKRB1(1), C1QA(1), C1QB(1), C1S(1), C3(4), C3AR1(1), C4BPA(2), C4BPB(1), C5(2), C6(4), C7(1), C8A(1), C8B(1), C9(3), CFH(4), CR1(3), CR2(2), F11(1), F12(1), F13A1(3), F13B(1), F2R(1), F5(5), F7(1), F8(3), FGA(2), FGB(2), FGG(2), KLKB1(2), KNG1(1), MASP1(3), MASP2(1), MBL2(1), PLG(1), PROS1(1), SERPINA1(1), SERPIND1(1), SERPINF2(1), TFPI(1), VWF(4) 33220924 76 52 76 28 7 24 17 19 8 1 0.585 1.000 1.000 533 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(1), ADCY2(2), ADCY3(1), ADCY5(1), ADCY7(1), ADCY8(2), ADCY9(1), CACNA1C(4), CACNA1D(2), CACNA1F(5), CACNA1S(5), CAMK2B(1), CAMK2G(1), EGFR(2), GNA11(1), GNAS(2), GNRH2(1), ITPR1(4), ITPR2(6), ITPR3(2), KRAS(2), MAP2K2(1), MAP2K3(2), MAP2K4(2), MAP2K6(2), MAP2K7(2), MAPK1(1), MAPK10(2), MAPK11(1), MAPK7(1), NRAS(1), PLA2G12B(1), PLA2G2D(1), PLA2G4A(1), PLCB1(4), PLCB2(1), PLCB3(1), PLCB4(3), PLD1(2), PRKACA(2), PRKCA(1), PTK2B(2) 48285926 81 50 81 35 18 20 10 19 14 0 0.628 1.000 1.000 534 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(1), ADCY8(2), BRAF(1), CACNA1C(4), CAMK2B(1), CAMK2G(1), CREBBP(4), EP300(2), GRIA1(6), GRIN1(2), GRIN2A(2), GRIN2D(1), GRM1(1), GRM5(4), ITPR1(4), ITPR2(6), ITPR3(2), KRAS(2), MAP2K2(1), MAPK1(1), NRAS(1), PLCB1(4), PLCB2(1), PLCB3(1), PLCB4(3), PPP1R12A(1), PPP1R1A(2), PPP3CC(2), PRKACA(2), PRKCA(1), PRKCG(1), RAP1A(1), RPS6KA1(1) 37574800 69 48 69 24 13 16 9 19 12 0 0.376 1.000 1.000 535 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1B(1), AURKB(1), BMPR2(1), CDIPT(1), CDS1(1), CLK1(1), CLK4(1), COL4A3BP(2), DGKB(1), DGKD(2), DGKE(1), DGKG(3), DGKH(2), INPP1(1), INPP4B(1), INPP5A(1), INPPL1(1), ITPKA(1), NEK1(2), PAK4(1), PIK3C2G(7), PIK3CA(6), PIK3CB(1), PIK3CG(2), PIM2(3), PLCB1(4), PLCB2(1), PLCB3(1), PLCB4(3), PLCG1(2), PRKACA(2), PRKAR2B(1), PRKCA(1), PRKCE(2), PRKCG(1), PRKCH(1), PRKCQ(2), PRKD1(1), PRKG1(1), RPS6KA1(1), TGFBR1(1), VRK1(1) 42650320 71 47 69 23 10 19 10 17 15 0 0.404 1.000 1.000 536 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA2(2), ACTN4(3), DMD(7), MYBPC2(1), MYBPC3(3), MYH3(4), MYH6(1), MYH7(7), MYL1(1), NEB(4), TNNT3(1), TTN(42) 51086978 76 47 76 39 14 20 20 8 13 1 0.980 1.000 1.000 537 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(1), ADCY2(2), ADCY3(1), ADCY5(1), ADCY7(1), ADCY8(2), ADCY9(1), AKAP10(1), AKAP11(3), AKAP12(2), AKAP2(1), AKAP3(1), AKAP5(1), AKAP6(3), AKAP8(1), AKAP9(2), ARHGEF1(1), GNA11(1), GNAL(1), GNAZ(1), GNB2(1), ITPR1(4), KCNJ3(1), KRAS(2), NRAS(1), PDE1A(2), PDE1B(2), PDE1C(4), PDE4A(3), PDE4B(1), PDE4C(2), PDE4D(2), PLCB3(1), PPP3CC(2), PRKACA(2), PRKAR2B(1), PRKCA(1), PRKCE(2), PRKCG(1), PRKCH(1), PRKCI(1), PRKCQ(2), PRKD1(1), PRKD3(2), RRAS(1) 42880422 71 46 71 25 10 17 13 10 20 1 0.524 1.000 1.000 538 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(2), ABCA10(1), ABCA13(8), ABCA2(1), ABCA3(2), ABCA4(2), ABCA5(2), ABCA6(1), ABCA7(2), ABCA8(2), ABCA9(5), ABCB11(2), ABCB4(3), ABCB5(5), ABCB6(1), ABCB7(1), ABCC1(1), ABCC10(2), ABCC11(1), ABCC12(4), ABCC2(2), ABCC3(5), ABCC8(4), ABCC9(1), ABCD1(1), ABCD4(1), ABCG1(2), ABCG5(1), CFTR(6) 44162436 71 45 71 30 7 24 12 15 13 0 0.413 1.000 1.000 539 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 98 ADCY1(1), ADCY2(2), ADCY3(1), ADCY5(1), ADCY7(1), ADCY8(2), ADCY9(1), ASIP(1), CAMK2B(1), CAMK2G(1), CREB3L3(1), CREBBP(4), DCT(2), DVL1(2), EP300(2), FZD2(1), FZD3(2), FZD5(1), FZD6(1), GNAS(2), KIT(4), KRAS(2), MAP2K2(1), MAPK1(1), NRAS(1), PLCB1(4), PLCB2(1), PLCB3(1), PLCB4(3), PRKACA(2), PRKCA(1), PRKCG(1), TCF7L1(1), TCF7L2(1), TYR(2), WNT10B(1), WNT2(1), WNT5A(1), WNT7B(1), WNT8A(1), WNT8B(1) 39944788 62 45 62 27 11 19 8 14 9 1 0.635 1.000 1.000 540 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADCY1(1), ADCY2(2), ADCY3(1), ADCY5(1), ADCY7(1), ADCY8(2), ADCY9(1), ADK(1), ADSL(1), ADSSL1(1), AK5(3), AK7(1), AMPD1(2), AMPD3(1), APRT(1), ENPP3(2), ENTPD1(1), ENTPD8(1), GART(1), GMPR2(1), GUCY1A3(1), GUCY1B3(2), GUCY2C(2), IMPDH2(1), NME2(1), NPR2(1), NT5E(1), PDE10A(1), PDE11A(1), PDE1A(2), PDE1C(4), PDE3B(3), PDE4A(3), PDE4B(1), PDE4C(2), PDE4D(2), PDE5A(1), PFAS(1), PKLR(2), PNPT1(2), POLD1(2), POLE(5), PPAT(1), PRIM2(1), RRM2(1) 60590743 70 42 70 29 8 18 20 12 12 0 0.699 1.000 1.000 541 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 BCR(2), BLNK(2), BTK(1), CD22(1), CD81(1), CR2(2), INPP5D(3), ITPR1(4), ITPR2(6), ITPR3(2), LYN(1), MAP4K1(3), MAPK1(1), NFATC2(1), PIK3CA(6), PIK3CD(1), PIK3R1(1), PPP1R13B(1), PPP3CC(2), PTPRC(4), SYK(1), VAV1(3) 27150574 49 40 48 19 11 6 13 8 11 0 0.743 1.000 1.000 542 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 71 ACACB(2), ACSL3(1), ACSL4(2), ACSL6(3), ADIPOR1(1), CAMKK1(2), CPT1A(1), CPT1B(1), G6PC2(1), IRS1(1), IRS4(3), JAK1(1), JAK3(2), MAPK10(2), NFKB1(1), PPARA(1), PPARGC1A(1), PRKAA2(4), PRKAB2(1), PRKCQ(2), PTPN11(3), RELA(2), RXRA(1), RXRG(1), SLC2A4(1), TNF(1), TNFRSF1A(1), TRAF2(2) 30727478 45 37 45 20 12 9 12 9 3 0 0.742 1.000 1.000 543 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADCY1(1), ADCY2(2), ADCY3(1), ADCY5(1), ADCY7(1), ADCY8(2), ADK(1), ADSL(1), AK5(3), AMPD1(2), AMPD3(1), APRT(1), ATP5B(1), ATP5C1(1), ATP5J2(1), ENPP3(2), ENTPD1(1), GART(1), GUCY1A3(1), GUCY1B3(2), GUCY2C(2), IMPDH2(1), NME2(1), NPR2(1), NT5E(1), PDE1A(2), PDE4A(3), PDE4B(1), PDE4C(2), PDE4D(2), PDE5A(1), PDE6B(3), PDE6C(1), PFAS(1), PKLR(2), POLD1(2), POLE(5), POLG(1), POLQ(6), POLRMT(1), PPAT(1), RRM2(1) 47510653 68 36 68 24 9 22 22 6 9 0 0.377 1.000 1.000 544 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 ALG1(1), ALG11(1), ALG13(1), ALG2(1), ALG6(1), ALG9(1), B3GNT2(2), B4GALT5(2), CHPF(1), CHST1(2), CHST11(1), CHST14(1), CHST3(1), CHST4(1), EXTL3(2), FUT8(1), GALNT10(1), GALNT13(1), GALNT14(3), GALNT3(1), GALNT5(1), GALNT7(1), GALNT8(2), GALNTL5(1), HS3ST1(1), HS3ST3A1(1), HS3ST3B1(1), HS3ST5(2), HS6ST1(1), MAN1A1(3), MAN1B1(1), MAN1C1(2), MGAT3(1), MGAT5B(2), NDST3(3), NDST4(3), OGT(1), RPN2(2), ST6GALNAC1(1), WBSCR17(2), XYLT2(2) 40665318 60 35 60 28 8 25 10 8 8 1 0.647 1.000 1.000 545 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 66 ATP6AP1(2), ATP6V0A4(1), ATP6V1A(2), ATP6V1E1(1), EGFR(2), F11R(4), LYN(1), MAP2K4(2), MAPK10(2), MAPK11(1), MET(4), NFKB1(1), NOD1(1), PAK1(1), PLCG1(2), PTPN11(3), PTPRZ1(5), RAC1(1), RELA(2), TCIRG1(1), TJP1(1) 25937187 40 32 40 14 6 11 7 7 9 0 0.474 1.000 1.000 546 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 57 ASH1L(2), CTCFL(2), EED(1), EHMT2(1), HCFC1(4), MEN1(1), OGT(1), PAXIP1(5), PRDM2(3), PRDM6(1), PRDM9(4), PRMT6(1), PRMT8(1), SATB1(2), SETD1A(3), SETD1B(3), SETD2(2), SETD8(1), SUV39H1(1), SUZ12(2), WHSC1(3) 46212148 44 31 44 18 4 20 6 4 10 0 0.757 1.000 1.000 547 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ADCY8(2), CACNA1A(7), CACNA1B(4), GNAS(2), GRM4(1), ITPR3(2), KCNB1(1), PDE1A(2), PLCB2(1), PRKACA(2), SCNN1B(1), SCNN1G(3), TAS1R1(2), TAS1R2(1), TAS1R3(1), TAS2R39(1), TAS2R40(1), TAS2R5(1), TAS2R7(1), TAS2R9(1), TRPM5(4) 21449520 41 29 40 23 11 10 7 6 7 0 0.744 1.000 1.000 548 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACADL(1), ACOX2(1), ACSL3(1), ACSL4(2), ACSL6(3), ANGPTL4(1), APOA5(1), CPT1A(1), CPT1B(1), CYP27A1(1), CYP4A11(1), CYP8B1(1), FABP4(1), FABP7(1), FADS2(1), GK2(2), HMGCS2(1), LPL(2), ME1(1), MMP1(2), PLTP(1), PPARA(1), RXRA(1), RXRG(1), SLC27A4(1), SLC27A5(1), SLC27A6(1), SORBS1(1) 23947823 34 28 34 20 7 7 8 8 4 0 0.965 1.000 1.000 549 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CTLA4(1), DTYMK(1), EPHB2(1), GRAP2(2), ITPKA(1), LCK(1), LCP2(1), MAPK1(1), NFAT5(4), NFKB1(1), NFKBIL1(1), PAK1(1), PAK3(3), PAK4(1), PAK7(1), PLCG1(2), PTPRC(4), VAV1(3), ZAP70(5) 21031784 35 28 35 12 7 11 4 7 6 0 0.489 1.000 1.000 550 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(1), AKR1D1(2), ARSE(1), CYP11B1(3), CYP11B2(1), CYP19A1(1), HEMK1(1), HSD11B1(1), HSD17B1(1), HSD17B12(1), HSD17B2(1), HSD3B1(1), PRMT2(2), PRMT3(1), PRMT6(1), PRMT8(1), SULT1E1(1), SULT2A1(1), UGT1A10(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT2A3(1), UGT2B11(3), UGT2B15(1), UGT2B17(2), WBSCR22(1) 18416833 35 27 35 17 7 7 3 10 8 0 0.929 1.000 1.000 551 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 BCR(2), BLNK(2), BTK(1), EPHB2(1), ITPKA(1), LYN(1), MAP2K2(1), MAPK1(1), NFAT5(4), NFKB1(1), NFKBIL1(1), PI3(1), PIK3CA(6), PIK3CD(1), PIK3R1(1), PPP1R13B(1), SERPINA4(1), SYK(1), VAV1(3) 19663501 31 27 30 13 8 3 5 7 8 0 0.834 1.000 1.000 552 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 ACAT1(1), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), AOC3(1), AOX1(2), CYP19A1(1), CYP1A2(2), CYP2A13(1), CYP2A6(1), CYP2C18(3), CYP2C19(2), CYP2C9(2), CYP2E1(2), CYP2F1(2), CYP2J2(2), CYP3A4(2), CYP3A7(1), CYP4B1(1), DDC(2), KYNU(2), MAOB(1), WARS(1), WARS2(1) 20431003 38 27 38 15 8 11 7 6 6 0 0.519 1.000 1.000 553 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 ACAT1(1), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), AOC3(1), AOX1(2), CYP1A2(2), DDC(2), HEMK1(1), HSD17B4(1), INMT(1), KYNU(2), MAOB(1), OGDHL(3), PRMT2(2), PRMT3(1), PRMT6(1), PRMT8(1), TPH2(3), WARS(1), WARS2(1), WBSCR22(1) 22396284 33 25 33 14 7 11 3 7 5 0 0.672 1.000 1.000 554 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(5), AXIN1(1), CCND1(1), DVL1(2), FZD2(1), FZD3(2), FZD5(1), FZD6(1), MAPK10(2), MYC(3), PPP2R5C(2), PPP2R5E(1), PRKCA(1), PRKCE(2), PRKCG(1), PRKCH(1), PRKCI(1), PRKCQ(2), PRKD1(1), RAC1(1), WNT10B(1), WNT2(1), WNT5A(1), WNT7B(1) 21786742 36 25 36 14 6 10 2 5 13 0 0.514 1.000 1.000 555 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 CHRM1(1), FLT1(1), FLT4(2), KDR(4), NOS3(2), PDE3A(1), PDE3B(3), PRKAR2B(1), PRKG1(1), PRKG2(1), RYR2(15), SYT1(1) 15294532 33 24 33 15 3 8 3 13 6 0 0.776 1.000 1.000 556 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(2), AR(4), ESR2(2), ESRRA(1), HNF4A(2), NR0B1(2), NR1D2(1), NR1I3(1), NR2E1(1), PPARA(1), RARA(1), RARB(3), RORC(1), RXRA(1), RXRG(1), THRA(1) 15369857 25 24 24 12 4 4 7 5 5 0 0.886 1.000 1.000 557 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 CDKN2A(1), INPPL1(1), IRS1(1), IRS4(3), LNPEP(2), MAPK1(1), PIK3CA(6), PIK3CD(1), PIK3R1(1), PTEN(8), RPS6KA1(1), SLC2A4(1), SORBS1(1), YWHAE(1) 21492460 29 24 28 11 2 4 5 10 8 0 0.793 1.000 1.000 558 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 AGMAT(1), ALDH1A2(1), ALDH1A3(2), ALDH2(1), ALDH9A1(1), AOC3(1), ARG2(2), CPS1(1), MAOB(1), NOS1(6), NOS3(2), P4HA2(1), P4HA3(1), PYCR1(2), RARS(2) 16459419 25 23 25 10 5 7 7 2 4 0 0.499 1.000 1.000 559 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F11(1), F12(1), F13B(1), F5(5), F7(1), F8(3), FGA(2), FGB(2), FGG(2), PLG(1), SERPINF2(1), VWF(4) 12796457 24 23 24 14 2 7 5 7 2 1 0.955 1.000 1.000 560 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AASDHPPT(1), AASS(1), ACAT1(1), AKR1B10(1), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), BBOX1(2), EHMT2(1), HSD17B4(1), OGDHL(3), PLOD2(2), PLOD3(1), SETD1A(3), SUV39H1(1), TMLHE(1) 21296603 24 23 24 13 2 6 5 5 6 0 0.886 1.000 1.000 561 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CLK4(1), CPSF1(1), CPSF3(1), DDX1(1), DHX38(1), DHX8(2), DICER1(3), DNAJC8(1), NUDT21(1), NXF1(1), PABPN1(1), PRPF4B(1), PRPF8(4), PTBP1(1), RBM17(1), RNMT(1), SF3A3(1), SF3B1(3), SF3B2(1), SNRPB2(1), SNRPE(1), SRPK1(2), SRPK2(2), SRRM1(2), SUPT5H(2), U2AF2(1) 39012084 38 23 38 11 3 14 5 7 9 0 0.389 1.000 1.000 562 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(1), AGTR2(1), ATP8A1(4), BDKRB1(1), C3AR1(1), CCKAR(1), CCKBR(2), CCR1(1), CCR3(1), CCR4(1), CXCR6(2), EDNRA(1), GHSR(2), GRPR(1), LHCGR(5), NTSR1(2), OPRM1(1), SSTR3(1), TACR1(2), TRHR(1) 18482217 32 23 31 16 5 9 5 3 10 0 0.779 1.000 1.000 563 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG2(1), ANGPTL2(2), FLNA(4), FLNC(3), GDI1(1), LIMK1(2), MYH2(6), MYLK(3), MYLK2(2), PAK1(1), PAK3(3), PAK4(1), PAK7(1), PFN2(1), RHO(1), ROCK1(1), ROCK2(1), VASP(1) 17780124 35 23 35 14 5 11 11 5 3 0 0.615 1.000 1.000 564 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 DPYD(6), DTYMK(1), ENTPD1(1), ENTPD8(1), NME2(1), NT5E(1), PNPT1(2), POLD1(2), POLE(5), PRIM2(1), RRM2(1), TXNRD1(4), TXNRD2(2), UMPS(1), UPP2(1) 30177398 30 22 30 10 2 10 7 7 4 0 0.510 1.000 1.000 565 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 BRAF(1), DRD2(1), EGFR(2), EPHB2(1), ITPKA(1), ITPR1(4), ITPR2(6), ITPR3(2), KCNJ3(1), KCNJ5(2), MAPK1(1), PI3(1), PIK3CB(1), PLCB1(4), PLCB2(1), PLCB3(1), PLCB4(3) 21573580 33 21 33 13 9 9 2 9 4 0 0.563 1.000 1.000 566 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 31 APC(5), AXIN1(1), AXIN2(2), DKK2(1), DVL1(2), LRP1(4), MVP(1), NKD2(2), PIN1(1), PTPRA(1), WIF1(3) 15107513 23 21 23 12 5 4 3 3 8 0 0.817 1.000 1.000 567 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), AOC3(1), ASPA(1), DDC(2), FTCD(1), HARS2(1), HDC(3), HEMK1(1), MAOB(1), PRMT2(2), PRMT3(1), PRMT6(1), PRMT8(1), UROC1(2), WBSCR22(1) 14839061 24 20 24 10 7 6 5 4 2 0 0.649 1.000 1.000 568 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(1), ABAT(1), ACAT1(1), AKR1B10(1), ALDH1A3(2), ALDH2(1), ALDH7A1(1), ALDH9A1(1), BDH2(2), GAD1(1), GAD2(2), HMGCS1(1), HMGCS2(1), HSD17B4(1), ILVBL(1), OXCT2(1), PDHA2(2), PDHB(1), PLA1A(2) 15067206 24 20 24 12 3 6 8 4 3 0 0.821 1.000 1.000 569 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 AGXT2(1), ALAS1(1), ALAS2(2), AOC3(1), CBS(1), CHDH(1), CPT1B(1), DMGDH(1), MAOB(1), PLCB2(1), PLCG1(2), PSPH(1), SARDH(3), SARS(2), TARS(1) 15858562 20 19 20 11 2 7 4 5 2 0 0.833 1.000 1.000 570 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ARG2(2), CPS1(1), EPRS(1), LAP3(2), NOS1(6), NOS3(2), P4HA2(1), P4HA3(1), PRODH(1), PYCR1(2), RARS(2) 13499792 21 19 21 10 6 7 5 0 3 0 0.614 1.000 1.000 571 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSE(1), CERK(1), GAL3ST1(1), GALC(2), GBA(1), GLA(1), LCT(4), NEU3(2), PPAP2A(1), PPAP2C(1), SGMS1(1), SGPP1(2), SMPD2(1), SMPD3(2), SPHK2(2), SPTLC1(1), UGT8(2) 13202900 26 19 25 11 4 6 4 3 9 0 0.683 1.000 1.000 572 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 B3GNT2(2), B4GALNT1(3), FUT1(3), FUT2(1), FUT5(1), FUT9(3), PIGB(1), PIGC(1), PIGG(1), PIGN(3), PIGT(1), ST3GAL5(1), ST6GALNAC3(1), ST6GALNAC5(1) 18011722 23 19 23 10 5 10 3 4 1 0 0.511 1.000 1.000 573 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 BCR(2), BLNK(2), LYN(1), MAPK1(1), MAPK8IP3(2), PAPPA(6), RAC1(1), RPS6KA1(1), SYK(1), VAV1(3), VAV2(3), VAV3(1) 12033101 24 18 24 10 5 6 4 4 5 0 0.600 1.000 1.000 574 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 AGXT2(1), AKR1B10(1), ALAS1(1), ALAS2(2), AOC3(1), CBS(1), CHDH(1), DMGDH(1), MAOB(1), PSPH(1), SARDH(3), SARS(2), TARS(1), TARS2(2) 16272176 19 17 19 10 2 7 5 4 1 0 0.760 1.000 1.000 575 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(1), ALOX15(1), ALOX5(1), CYP1A2(2), CYP2C18(3), CYP2C19(2), CYP2C9(2), CYP2E1(2), CYP2J2(2), CYP3A4(2), CYP3A7(1), PLA2G12B(1), PLA2G2D(1), PLA2G4A(1) 9052997 22 17 22 10 5 6 6 2 3 0 0.585 1.000 1.000 576 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(1), AKR1D1(2), ARSE(1), CYP11B1(3), CYP11B2(1), HSD11B1(1), HSD17B2(1), HSD3B1(1), SULT1E1(1), SULT2A1(1), UGT1A10(1), UGT1A4(1), UGT1A5(2), UGT1A6(1), UGT2B15(1) 9997289 19 16 19 13 4 1 1 7 6 0 0.988 1.000 1.000 577 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(2), MRPL19(1), RPL13A(1), RPL17(1), RPL36(1), RPL41(1), RPL5(3), RPL7(1), RPS20(1), RPS23(1), RPS26(1), RPS6KA1(1), RPS7(1), SLC36A2(2), UBB(2) 19665065 20 16 20 11 2 8 7 2 1 0 0.843 1.000 1.000 578 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS2(2), ABAT(1), ADSL(1), ADSSL1(1), AGXT2(1), ASNS(1), ASPA(1), ASRGL1(1), DARS(1), DLAT(1), GAD1(1), GAD2(2), GPT2(2), PDHA2(2), PDHB(1) 14000866 19 15 19 10 2 9 2 3 3 0 0.728 1.000 1.000 579 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(1), CPS1(1), EARS2(1), EPRS(1), GAD1(1), GAD2(2), GCLC(1), GLUL(1), GPT2(2), PPAT(1), QARS(1) 14466766 13 10 13 11 3 2 4 3 1 0 0.983 1.000 1.000 580 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 IL2RB(4), IL2RG(1), JAK1(1), JAK3(2), LCK(1), STAT5A(1), SYK(1) 8858150 11 10 11 5 4 3 2 2 0 0 0.602 1.000 1.000 581 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(1), CPS1(1), EPRS(1), GAD1(1), GAD2(2), GCLC(1), GLUL(1), GPT2(2), PPAT(1), QARS(1) 12130172 12 9 12 11 3 2 3 3 1 0 0.989 1.000 1.000 582 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B4GALNT1(3), LCT(4), ST3GAL5(1), ST6GALNAC3(1), ST6GALNAC5(1) 5891489 10 9 10 6 3 1 4 2 0 0 0.875 1.000 1.000 583 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 RPL13A(1), RPL36A(2), RPL41(1), RPL7(1), RPS20(1), RPS23(1), RPS26(1), RPS7(1) 8609902 9 9 9 4 4 1 3 1 0 0 0.817 1.000 1.000 584 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST1(1), HS3ST3A1(1), HS3ST3B1(1), XYLT2(2) 2499150 5 5 5 4 1 2 1 1 0 0 0.868 1.000 1.000 585 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST1(1), HS3ST3A1(1), HS3ST3B1(1), XYLT2(2) 2499150 5 5 5 4 1 2 1 1 0 0 0.868 1.000 1.000 586 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(1), GNAS(2), XPO1(1) 3488452 4 4 4 3 2 0 0 2 0 0 0.917 1.000 1.000 587 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(2), CYP2A13(1), CYP2A6(1) 2980611 4 4 4 3 1 1 1 1 0 0 0.839 1.000 1.000 588 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 FADS2(1), PLA2G12B(1), PLA2G2D(1), PLA2G4A(1) 3951462 4 4 4 5 1 2 1 0 0 0 0.981 1.000 1.000 589 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(1), HLA-DRB1(1), IL5RA(2) 1950510 4 4 4 3 1 0 1 2 0 0 0.888 1.000 1.000 590 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 HMGB1(1), TOP2A(1), TOP2B(1) 3905917 3 3 3 3 0 0 1 2 0 0 0.979 1.000 1.000 591 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 GAD1(1), GAD2(2), GGT1(1) 2153032 4 3 4 3 0 1 1 2 0 0 0.891 1.000 1.000 592 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 GREB1(2), PDZK1(1), TUBA8(1) 4188823 4 3 4 4 2 0 0 2 0 0 0.917 1.000 1.000 593 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNH(1), CDC25B(1), XPO1(1) 3204314 3 3 3 3 0 2 0 1 0 0 0.935 1.000 1.000 594 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCR3(1), HLA-DRB1(1) 1120455 2 2 2 3 1 0 1 0 0 0 0.958 1.000 1.000 595 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(1), PGLYRP2(1) 639317 2 2 2 2 1 0 1 0 0 0 0.960 1.000 1.000 596 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA2(1), JAK1(1) 3899948 2 2 2 3 0 1 1 0 0 0 0.977 1.000 1.000 597 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA2(1), JAK1(1) 3899948 2 2 2 3 0 1 1 0 0 0 0.977 1.000 1.000 598 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 PRODH(1) 2159482 1 1 1 2 1 0 0 0 0 0 0.960 1.000 1.000 599 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 HLA-DRB1(1) 1440279 1 1 1 2 1 0 0 0 0 0 0.945 1.000 1.000 600 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(1) 1161150 1 1 1 2 0 0 0 1 0 0 0.981 1.000 1.000 601 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 ARHGAP5(1) 4648388 1 1 1 2 0 0 0 1 0 0 0.977 1.000 1.000 602 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(1) 806027 1 1 1 3 0 0 1 0 0 0 0.991 1.000 1.000 603 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMPR2(1) 2236538 1 1 1 2 0 1 0 0 0 0 0.951 1.000 1.000 604 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 1787097 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 605 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 587010 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 606 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 1622826 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 607 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 261215 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 608 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 186864 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 609 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 819572 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 610 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 1119807 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 611 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 550247 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 612 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 8421688 0 0 0 2 0 0 0 0 0 0 1.000 1.000 1.000 613 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 4999135 0 0 0 2 0 0 0 0 0 0 1.000 1.000 1.000 614 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 603726 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 615 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 1349812 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 616 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 2627070 0 0 0 2 0 0 0 0 0 0 1.000 1.000 1.000