E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.249 0.287 -9999.0 0.0 -0.58 111.0 111.0 KLHL20 -0.074 0.084 -9999.0 0.0 -0.351 1.0 1.0 CYFIP2 -0.092 0.255 -9999.0 0.0 -0.797 30.0 30.0 Rac1/GDP -0.12 0.196 -9999.0 0.0 -0.397 3.0 3.0 ENAH -0.249 0.287 -9999.0 0.0 -0.58 111.0 111.0 AP1M1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B -0.002 0.028 -9999.0 0.0 -0.322 2.0 2.0 RAP1A 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.122 0.14 -9999.0 0.0 -0.371 2.0 2.0 ABI1/Sra1/Nap1 -0.064 0.077 -9999.0 0.0 -0.237 24.0 24.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.207 0.235 -9999.0 0.0 -0.478 111.0 111.0 RAPGEF1 -0.182 0.263 -9999.0 0.0 -0.486 111.0 111.0 CTNND1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.259 0.298 -9999.0 0.0 -0.602 111.0 111.0 CRK -0.207 0.285 -9999.0 0.0 -0.536 111.0 111.0 E-cadherin/gamma catenin/alpha catenin -0.227 0.259 -9999.0 0.0 -0.526 111.0 111.0 alphaE/beta7 Integrin -0.002 0.018 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin -0.003 0.033 -9999.0 0.0 -0.485 1.0 1.0 DLG1 -0.249 0.287 -9999.0 0.0 -0.579 111.0 111.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.089 0.101 -9999.0 0.0 -0.259 1.0 1.0 MLLT4 -0.003 0.049 -9999.0 0.0 -0.796 1.0 1.0 ARF6/GTP/NME1/Tiam1 -0.005 0.025 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.115 0.13 -9999.0 0.0 -0.342 1.0 1.0 ARF6 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.263 0.301 -9999.0 0.0 -0.609 111.0 111.0 TIAM1 -0.01 0.056 -9999.0 0.0 -0.322 8.0 8.0 E-cadherin(dimer)/Ca2+ -0.195 0.224 -9999.0 0.0 -0.454 111.0 111.0 AKT1 -0.064 0.073 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 -0.004 0.053 -9999.0 0.0 -0.559 2.0 2.0 CDH1 -0.344 0.393 -9999.0 0.0 -0.788 113.0 113.0 RhoA/GDP -0.12 0.196 -9999.0 0.0 -0.347 107.0 107.0 actin cytoskeleton organization -0.055 0.062 -9999.0 0.0 -0.245 1.0 1.0 CDC42/GDP -0.12 0.196 -9999.0 0.0 -0.347 107.0 107.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.146 0.168 -9999.0 0.0 -0.34 111.0 111.0 ITGB7 -0.002 0.028 -9999.0 0.0 -0.322 2.0 2.0 RAC1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.206 0.236 -9999.0 0.0 -0.478 111.0 111.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.198 0.227 -9999.0 0.0 -0.46 111.0 111.0 mol:GDP -0.149 0.229 -9999.0 0.0 -0.412 111.0 111.0 CDC42/GTP/IQGAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP -0.152 0.174 -9999.0 0.0 -0.39 4.0 4.0 RAC1/GTP/IQGAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle -0.035 0.042 -9999.0 0.0 -0.292 1.0 1.0 NME1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.249 0.287 -9999.0 0.0 -0.58 111.0 111.0 regulation of cell-cell adhesion -0.108 0.123 -9999.0 0.0 -0.321 2.0 2.0 WASF2 -0.033 0.039 -9999.0 0.0 -0.141 1.0 1.0 Rap1/GTP -0.141 0.161 -9999.0 0.0 -0.43 2.0 2.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.193 0.22 -9999.0 0.0 -0.447 111.0 111.0 CCND1 -0.042 0.051 -9999.0 0.0 -0.375 1.0 1.0 VAV2 -0.197 0.276 -9999.0 0.0 -0.515 111.0 111.0 RAP1/GDP -0.143 0.164 -9999.0 0.0 -0.429 2.0 2.0 adherens junction assembly -0.239 0.276 -9999.0 0.0 -0.558 111.0 111.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.183 0.209 -9999.0 0.0 -0.424 111.0 111.0 E-cadherin/beta catenin -0.213 0.245 -9999.0 0.0 -0.496 111.0 111.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.249 0.286 -9999.0 0.0 -0.579 111.0 111.0 PIK3CA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.117 0.135 -9999.0 0.0 -0.393 5.0 5.0 E-cadherin/beta catenin/alpha catenin -0.227 0.259 -9999.0 0.0 -0.526 111.0 111.0 ITGAE 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.266 0.306 -9999.0 0.0 -0.619 111.0 111.0