Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.076 0.202 -9999.0 0.0 -0.628 6.0 6.0 IHH -0.16 0.33 -9999.0 0.0 -0.816 52.0 52.0 SHH Np/Cholesterol/GAS1 -0.079 0.177 -9999.0 0.0 -0.485 41.0 41.0 LRPAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.079 0.176 0.481 41.0 -9999.0 0.0 41.0 SMO/beta Arrestin2 -0.127 0.21 -9999.0 0.0 -0.515 52.0 52.0 SMO -0.136 0.223 -9999.0 0.0 -0.545 53.0 53.0 AKT1 -0.057 0.092 -9999.0 0.0 -0.323 3.0 3.0 ARRB2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.012 0.082 -9999.0 0.0 -0.458 7.0 7.0 ADRBK1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.11 0.235 -9999.0 0.0 -0.536 53.0 53.0 STIL -0.178 0.222 -9999.0 0.0 -0.522 58.0 58.0 DHH N/PTCH2 -0.043 0.142 -9999.0 0.0 -0.622 13.0 13.0 DHH N/PTCH1 -0.125 0.204 -9999.0 0.0 -0.465 60.0 60.0 PIK3CA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.042 0.171 -9999.0 0.0 -0.678 16.0 16.0 PTHLH -0.098 0.267 -9999.0 0.0 -1.155 6.0 6.0 determination of left/right symmetry -0.11 0.235 -9999.0 0.0 -0.536 53.0 53.0 PIK3R1 -0.004 0.053 -9999.0 0.0 -0.559 2.0 2.0 skeletal system development -0.096 0.264 -9999.0 0.0 -1.132 6.0 6.0 IHH N/Hhip -0.247 0.316 -9999.0 0.0 -0.643 93.0 93.0 DHH N/Hhip -0.16 0.269 -9999.0 0.0 -0.634 60.0 60.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.11 0.235 -9999.0 0.0 -0.536 53.0 53.0 pancreas development -0.172 0.314 -9999.0 0.0 -0.686 65.0 65.0 HHAT 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.003 0.04 -9999.0 0.0 -0.609 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.006 0.057 -9999.0 0.0 -0.48 3.0 3.0 somite specification -0.11 0.235 -9999.0 0.0 -0.536 53.0 53.0 SHH Np/Cholesterol/PTCH1 -0.157 0.219 -9999.0 0.0 -0.525 42.0 42.0 SHH Np/Cholesterol/PTCH2 -0.085 0.177 -9999.0 0.0 -0.485 41.0 41.0 SHH Np/Cholesterol/Megalin -0.303 0.297 -9999.0 0.0 -0.552 142.0 142.0 SHH -0.087 0.224 -9999.0 0.0 -0.61 40.0 40.0 catabolic process -0.088 0.21 -9999.0 0.0 -0.478 52.0 52.0 SMO/Vitamin D3 -0.165 0.233 -9999.0 0.0 -0.74 17.0 17.0 SHH Np/Cholesterol/Hhip -0.178 0.263 -9999.0 0.0 -0.547 80.0 80.0 LRP2 -0.372 0.397 -9999.0 0.0 -0.797 121.0 121.0 receptor-mediated endocytosis -0.297 0.276 -9999.0 0.0 -0.73 55.0 55.0 SHH Np/Cholesterol/BOC -0.083 0.18 -9999.0 0.0 -0.489 42.0 42.0 SHH Np/Cholesterol/CDO -0.08 0.177 -9999.0 0.0 -0.485 41.0 41.0 mesenchymal cell differentiation 0.177 0.26 0.542 80.0 -9999.0 0.0 80.0 mol:Vitamin D3 -0.134 0.237 -9999.0 0.0 -0.453 80.0 80.0 IHH N/PTCH2 -0.123 0.221 -9999.0 0.0 -0.545 52.0 52.0 CDON -0.008 0.063 -9999.0 0.0 -0.417 5.0 5.0 IHH N/PTCH1 -0.107 0.202 -9999.0 0.0 -0.484 52.0 52.0 Megalin/LRPAP1 -0.284 0.304 -9999.0 0.0 -0.609 121.0 121.0 PTCH2 -0.018 0.083 -9999.0 0.0 -0.359 13.0 13.0 SHH Np/Cholesterol -0.077 0.178 -9999.0 0.0 -0.492 40.0 40.0 PTCH1 -0.088 0.211 -9999.0 0.0 -0.48 52.0 52.0 HHIP -0.172 0.314 -9999.0 0.0 -0.687 65.0 65.0