Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.142 0.164 -9999.0 0.0 -0.331 111.0 111.0 epithelial cell differentiation -0.193 0.221 -9999.0 0.0 -0.449 111.0 111.0 CYFIP2 -0.092 0.255 -9999.0 0.0 -0.797 30.0 30.0 ENAH -0.078 0.158 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.006 0.057 -9999.0 0.0 -0.48 3.0 3.0 EPHA2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.183 0.21 -9999.0 0.0 -0.426 111.0 111.0 CTNNB1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.061 0.168 -9999.0 0.0 -0.526 30.0 30.0 AQP5 -0.178 0.208 -9999.0 0.0 -0.397 116.0 116.0 CTNND1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.18 0.206 -9999.0 0.0 -0.418 111.0 111.0 regulation of calcium-dependent cell-cell adhesion -0.192 0.214 -9999.0 0.0 -0.426 116.0 116.0 EGF -0.317 0.39 -9999.0 0.0 -0.797 103.0 103.0 NCKAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.305 0.309 -9999.0 0.0 -0.739 65.0 65.0 cortical microtubule organization -0.193 0.221 -9999.0 0.0 -0.449 111.0 111.0 GO:0000145 -0.155 0.212 -9999.0 0.0 -0.399 111.0 111.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.195 0.224 -9999.0 0.0 -0.454 111.0 111.0 MLLT4 -0.003 0.049 -9999.0 0.0 -0.797 1.0 1.0 ARF6/GDP -0.151 0.173 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.171 0.194 -9999.0 0.0 -0.394 111.0 111.0 PVRL2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.183 0.21 -9999.0 0.0 -0.426 111.0 111.0 ARF6/GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.344 0.393 -9999.0 0.0 -0.788 113.0 113.0 EGFR/EGFR/EGF/EGF -0.345 0.317 -9999.0 0.0 -0.564 158.0 158.0 RhoA/GDP -0.181 0.208 -9999.0 0.0 -0.421 111.0 111.0 actin cytoskeleton organization -0.173 0.198 -9999.0 0.0 -0.402 111.0 111.0 IGF-1R heterotetramer -0.009 0.085 -9999.0 0.0 -0.795 3.0 3.0 GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R -0.009 0.085 -9999.0 0.0 -0.797 3.0 3.0 IGF1 -0.02 0.103 -9999.0 0.0 -0.441 12.0 12.0 DIAPH1 -0.101 0.247 -9999.0 0.0 -0.781 30.0 30.0 Wnt receptor signaling pathway 0.193 0.221 0.449 111.0 -9999.0 0.0 111.0 RHOA 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.153 0.175 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.177 0.204 -9999.0 0.0 -0.412 111.0 111.0 EFNA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.176 0.197 -9999.0 0.0 -0.402 111.0 111.0 Ephrin A1/EPHA2 -0.175 0.201 -9999.0 0.0 -0.407 111.0 111.0 SEC6/SEC8 -0.162 0.184 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.195 0.218 -9999.0 0.0 -0.433 116.0 116.0 HGF/MET -0.201 0.22 -9999.0 0.0 -0.427 121.0 121.0 HGF -0.038 0.164 -9999.0 0.0 -0.695 14.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.144 0.165 -9999.0 0.0 -0.334 111.0 111.0 actin cable formation -0.075 0.162 -9999.0 0.0 -0.331 23.0 23.0 KIAA1543 -0.351 0.305 -9999.0 0.0 -0.545 166.0 166.0 KIFC3 -0.185 0.214 -9999.0 0.0 -0.429 111.0 111.0 NCK1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.183 0.21 -9999.0 0.0 -0.426 111.0 111.0 NCK1/GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.193 0.221 -9999.0 0.0 -0.449 111.0 111.0 EXOC4 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.183 0.21 -9999.0 0.0 -0.426 111.0 111.0 PIP5K1C -0.183 0.21 -9999.0 0.0 -0.426 111.0 111.0 LIMA1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.133 0.153 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly -0.303 0.302 -9999.0 0.0 -0.729 60.0 60.0 IGF-1R heterotetramer/IGF1 -0.189 0.207 -9999.0 0.0 -0.415 116.0 116.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin -0.002 0.038 -9999.0 0.0 -0.609 1.0 1.0 MET -0.012 0.098 -9999.0 0.0 -0.797 4.0 4.0 PLEKHA7 -0.19 0.221 -9999.0 0.0 -0.437 112.0 112.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.154 0.175 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.142 0.164 -9999.0 0.0 -0.331 111.0 111.0 regulation of cell-cell adhesion -0.173 0.198 -9999.0 0.0 -0.402 111.0 111.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.144 0.165 -9999.0 0.0 -0.334 111.0 111.0