Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXA2 and FOXA3 transcription factor networks	109.0	5049.0	46.0	-1.49	0.01	1000.0	-1000.0	-0.065	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	78.0	2671.0	34.0	-0.367	0.0	1000.0	-1000.0	-0.063	-1000.0
E-cadherin signaling events	67.0	335.0	5.0	-0.344	0.0	1000.0	-1000.0	-0.042	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	56.0	4180.0	74.0	-0.351	0.193	1000.0	-1000.0	-0.089	-1000.0
ErbB2/ErbB3 signaling events	52.0	3442.0	65.0	-0.519	0.026	1000.0	-1000.0	-0.062	-1000.0
IL4-mediated signaling events	46.0	4265.0	91.0	-1.314	0.771	1000.0	-1000.0	-0.147	-1000.0
EGFR-dependent Endothelin signaling events	45.0	961.0	21.0	-0.317	0.0	1000.0	-1000.0	-0.061	-1000.0
Signaling events mediated by the Hedgehog family	40.0	2083.0	52.0	-0.372	0.177	1000.0	-1000.0	-0.075	-1000.0
Signaling mediated by p38-alpha and p38-beta	39.0	1722.0	44.0	-0.403	0.0	1000.0	-1000.0	-0.054	-1000.0
E-cadherin signaling in the nascent adherens junction	39.0	2977.0	76.0	-0.344	0.0	1000.0	-1000.0	-0.08	-1000.0
Glypican 2 network	38.0	155.0	4.0	-0.104	-0.095	1000.0	-1000.0	-0.03	-1000.0
TCGA08_retinoblastoma	35.0	286.0	8.0	-0.253	0.053	1000.0	-1000.0	-0.022	-1000.0
Wnt signaling	34.0	238.0	7.0	-0.088	-0.01	1000.0	-1000.0	-0.044	-1000.0
TCGA08_p53	28.0	199.0	7.0	-0.165	0.032	1000.0	-1000.0	-0.021	-1000.0
Reelin signaling pathway	27.0	1541.0	56.0	-0.275	0.0	1000.0	-1000.0	-0.097	-1000.0
Signaling events regulated by Ret tyrosine kinase	27.0	2222.0	82.0	-0.265	0.0	1000.0	-1000.0	-0.079	-1000.0
Syndecan-1-mediated signaling events	26.0	888.0	34.0	-0.29	0.0	1000.0	-1000.0	-0.074	-1000.0
E-cadherin signaling in keratinocytes	23.0	1009.0	43.0	-0.343	0.083	1000.0	-1000.0	-0.079	-1000.0
Osteopontin-mediated events	22.0	838.0	38.0	-0.149	0.0	1000.0	-1000.0	-0.101	-1000.0
amb2 Integrin signaling	22.0	1832.0	82.0	-0.3	0.005	1000.0	-1000.0	-0.081	-1000.0
Aurora B signaling	21.0	1443.0	67.0	-0.313	0.001	1000.0	-1000.0	-0.067	-1000.0
Thromboxane A2 receptor signaling	19.0	2034.0	105.0	-0.317	0.014	1000.0	-1000.0	-0.061	-1000.0
Noncanonical Wnt signaling pathway	18.0	489.0	26.0	-0.088	0.0	1000.0	-1000.0	-0.076	-1000.0
Integrins in angiogenesis	18.0	1536.0	84.0	-0.443	0.007	1000.0	-1000.0	-0.096	-1000.0
Aurora C signaling	16.0	115.0	7.0	-0.133	0.0	1000.0	-1000.0	-0.039	-1000.0
BMP receptor signaling	16.0	1329.0	81.0	-0.398	0.028	1000.0	-1000.0	-0.084	-1000.0
FOXM1 transcription factor network	16.0	859.0	51.0	-0.239	0.014	1000.0	-1000.0	-0.157	-1000.0
LPA4-mediated signaling events	15.0	180.0	12.0	-0.19	0.017	1000.0	-1000.0	-0.023	-1000.0
Coregulation of Androgen receptor activity	15.0	1214.0	76.0	-0.701	0.027	1000.0	-1000.0	-0.055	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	15.0	849.0	54.0	-0.197	0.019	1000.0	-1000.0	-0.096	-1000.0
Ephrin A  reverse signaling	14.0	101.0	7.0	-0.072	-0.0	1000.0	-1000.0	-0.038	-1000.0
Arf6 signaling events	14.0	917.0	62.0	-0.317	0.012	1000.0	-1000.0	-0.065	-1000.0
Fc-epsilon receptor I signaling in mast cells	14.0	1443.0	97.0	-0.143	0.026	1000.0	-1000.0	-0.08	-1000.0
PDGFR-alpha signaling pathway	14.0	638.0	44.0	-0.108	0.007	1000.0	-1000.0	-0.062	-1000.0
TCR signaling in naïve CD8+ T cells	14.0	1326.0	93.0	-0.214	0.104	1000.0	-1000.0	-0.087	-1000.0
Syndecan-4-mediated signaling events	14.0	960.0	67.0	-0.18	0.036	1000.0	-1000.0	-0.086	-1000.0
IL23-mediated signaling events	14.0	887.0	60.0	-0.242	0.014	1000.0	-1000.0	-0.14	-1000.0
p75(NTR)-mediated signaling	13.0	1694.0	125.0	-0.483	0.027	1000.0	-1000.0	-0.093	-1000.0
S1P5 pathway	13.0	230.0	17.0	-0.103	0.059	1000.0	-1000.0	-0.053	-1000.0
Endothelins	13.0	1321.0	96.0	-0.491	0.024	1000.0	-1000.0	-0.082	-1000.0
Angiopoietin receptor Tie2-mediated signaling	13.0	1208.0	88.0	-0.24	0.021	1000.0	-1000.0	-0.113	-1000.0
S1P4 pathway	12.0	310.0	25.0	-0.103	0.0	1000.0	-1000.0	-0.057	-1000.0
Visual signal transduction: Cones	11.0	425.0	38.0	-0.139	0.0	1000.0	-1000.0	-0.069	-1000.0
Calcium signaling in the CD4+ TCR pathway	11.0	365.0	31.0	-0.245	0.0	1000.0	-1000.0	-0.105	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	11.0	378.0	33.0	-0.244	0.0	1000.0	-1000.0	-0.063	-1000.0
Class IB PI3K non-lipid kinase events	11.0	33.0	3.0	-0.034	-1000.0	1000.0	-1000.0	-0.023	-1000.0
ErbB4 signaling events	10.0	755.0	69.0	-0.103	0.041	1000.0	-1000.0	-0.087	-1000.0
Signaling events mediated by PTP1B	10.0	824.0	76.0	-0.319	0.036	1000.0	-1000.0	-0.076	-1000.0
Glypican 1 network	10.0	485.0	48.0	-0.244	0.007	1000.0	-1000.0	-0.054	-1000.0
Insulin-mediated glucose transport	10.0	341.0	32.0	-0.159	0.019	1000.0	-1000.0	-0.055	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	10.0	558.0	52.0	-0.176	0.042	1000.0	-1000.0	-0.061	-1000.0
S1P1 pathway	10.0	379.0	36.0	-0.227	0.012	1000.0	-1000.0	-0.073	-1000.0
Nongenotropic Androgen signaling	10.0	536.0	52.0	-0.103	0.009	1000.0	-1000.0	-0.064	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	10.0	738.0	68.0	-0.211	0.027	1000.0	-1000.0	-0.126	-1000.0
IL2 signaling events mediated by STAT5	10.0	221.0	22.0	-0.095	0.028	1000.0	-1000.0	-0.072	-1000.0
S1P3 pathway	10.0	438.0	42.0	-0.103	0.001	1000.0	-1000.0	-0.056	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	10.0	798.0	78.0	-0.087	0.037	1000.0	-1000.0	-0.084	-1000.0
IL12-mediated signaling events	9.0	792.0	87.0	-0.1	0.022	1000.0	-1000.0	-0.12	-1000.0
HIF-1-alpha transcription factor network	9.0	701.0	76.0	-0.371	0.061	1000.0	-1000.0	-0.132	-1000.0
Glucocorticoid receptor regulatory network	9.0	1129.0	114.0	-0.234	0.178	1000.0	-1000.0	-0.071	-1000.0
Signaling mediated by p38-gamma and p38-delta	9.0	139.0	15.0	-0.144	0.02	1000.0	-1000.0	-0.055	-1000.0
Visual signal transduction: Rods	9.0	500.0	52.0	-0.139	0.0	1000.0	-1000.0	-0.084	-1000.0
Regulation of Androgen receptor activity	9.0	666.0	70.0	-0.736	0.012	1000.0	-1000.0	-0.073	-1000.0
Regulation of nuclear SMAD2/3 signaling	8.0	1122.0	136.0	-0.372	0.067	1000.0	-1000.0	-0.079	-1000.0
Presenilin action in Notch and Wnt signaling	8.0	498.0	61.0	-0.131	0.042	1000.0	-1000.0	-0.069	-1000.0
PLK1 signaling events	8.0	754.0	85.0	-0.168	0.01	1000.0	-1000.0	-0.06	-1000.0
LPA receptor mediated events	8.0	877.0	102.0	-0.148	0.027	1000.0	-1000.0	-0.084	-1000.0
Insulin Pathway	8.0	661.0	74.0	-0.258	0.031	1000.0	-1000.0	-0.083	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	8.0	990.0	120.0	-0.167	0.053	1000.0	-1000.0	-0.069	-1000.0
Sphingosine 1-phosphate (S1P) pathway	7.0	222.0	28.0	-0.103	0.0	1000.0	-1000.0	-0.057	-1000.0
Nectin adhesion pathway	7.0	449.0	63.0	-0.344	0.034	1000.0	-1000.0	-0.069	-1000.0
Ephrin B reverse signaling	7.0	360.0	48.0	-0.051	0.03	1000.0	-1000.0	-0.066	-1000.0
FoxO family signaling	7.0	499.0	64.0	-0.407	0.039	1000.0	-1000.0	-0.084	-1000.0
Regulation of Telomerase	7.0	716.0	102.0	-0.357	0.017	1000.0	-1000.0	-0.092	-1000.0
Plasma membrane estrogen receptor signaling	7.0	659.0	86.0	-0.114	0.03	1000.0	-1000.0	-0.08	-1000.0
BARD1 signaling events	6.0	351.0	57.0	-0.16	0.104	1000.0	-1000.0	-0.066	-1000.0
Canonical Wnt signaling pathway	6.0	347.0	51.0	-0.131	0.04	1000.0	-1000.0	-0.059	-1000.0
Effects of Botulinum toxin	6.0	175.0	26.0	-0.106	0.0	1000.0	-1000.0	-0.06	-1000.0
PLK2 and PLK4 events	5.0	15.0	3.0	-0.017	0.005	1000.0	-1000.0	-0.022	-1000.0
Syndecan-2-mediated signaling events	5.0	353.0	69.0	-0.188	0.032	1000.0	-1000.0	-0.058	-1000.0
Ceramide signaling pathway	5.0	416.0	76.0	-0.317	0.105	1000.0	-1000.0	-0.068	-1000.0
IL2 signaling events mediated by PI3K	5.0	296.0	58.0	-0.077	0.049	1000.0	-1000.0	-0.08	-1000.0
IL27-mediated signaling events	5.0	276.0	51.0	-0.135	0.005	1000.0	-1000.0	-0.072	-1000.0
Signaling events mediated by PRL	5.0	184.0	34.0	-0.179	0.027	1000.0	-1000.0	-0.068	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	4.0	367.0	85.0	-0.049	0.037	1000.0	-1000.0	-0.07	-1000.0
IL1-mediated signaling events	4.0	298.0	62.0	-0.09	0.022	1000.0	-1000.0	-0.101	-1000.0
FAS signaling pathway (CD95)	4.0	217.0	47.0	-0.114	0.017	1000.0	-1000.0	-0.05	-1000.0
Retinoic acid receptors-mediated signaling	4.0	247.0	58.0	-0.058	0.032	1000.0	-1000.0	-0.067	-1000.0
Syndecan-3-mediated signaling events	4.0	140.0	35.0	-0.064	0.0	1000.0	-1000.0	-0.068	-1000.0
IL6-mediated signaling events	4.0	371.0	75.0	-0.075	0.082	1000.0	-1000.0	-0.093	-1000.0
Arf6 trafficking events	4.0	292.0	71.0	-0.354	0.08	1000.0	-1000.0	-0.069	-1000.0
BCR signaling pathway	4.0	401.0	99.0	-0.068	0.037	1000.0	-1000.0	-0.076	-1000.0
Ras signaling in the CD4+ TCR pathway	4.0	73.0	17.0	-0.033	0.02	1000.0	-1000.0	-0.063	-1000.0
Caspase cascade in apoptosis	3.0	237.0	74.0	-0.129	0.037	1000.0	-1000.0	-0.057	-1000.0
JNK signaling in the CD4+ TCR pathway	3.0	60.0	17.0	-0.025	0.036	1000.0	-1000.0	-0.07	-1000.0
Cellular roles of Anthrax toxin	3.0	138.0	39.0	-0.107	0.018	1000.0	-1000.0	-0.032	-1000.0
Aurora A signaling	3.0	239.0	60.0	-0.159	0.016	1000.0	-1000.0	-0.059	-1000.0
IFN-gamma pathway	3.0	217.0	68.0	-0.086	0.047	1000.0	-1000.0	-0.088	-1000.0
Class I PI3K signaling events mediated by Akt	3.0	260.0	68.0	-0.212	0.037	1000.0	-1000.0	-0.062	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	3.0	133.0	37.0	-0.065	0.0	1000.0	-1000.0	-0.073	-1000.0
TRAIL signaling pathway	3.0	177.0	48.0	-0.036	0.037	1000.0	-1000.0	-0.058	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	3.0	304.0	83.0	-0.09	0.017	1000.0	-1000.0	-0.076	-1000.0
EPHB forward signaling	3.0	288.0	85.0	-0.137	0.046	1000.0	-1000.0	-0.079	-1000.0
Regulation of p38-alpha and p38-beta	3.0	174.0	54.0	-0.07	0.036	1000.0	-1000.0	-0.069	-1000.0
IGF1 pathway	3.0	180.0	57.0	-0.059	0.034	1000.0	-1000.0	-0.089	-1000.0
Rapid glucocorticoid signaling	3.0	64.0	20.0	-0.041	0.006	1000.0	-1000.0	-0.035	-1000.0
Signaling events mediated by HDAC Class II	2.0	219.0	75.0	-0.143	0.002	1000.0	-1000.0	-0.057	-1000.0
Hedgehog signaling events mediated by Gli proteins	2.0	168.0	65.0	-0.103	0.037	1000.0	-1000.0	-0.079	-1000.0
Signaling events mediated by HDAC Class III	2.0	113.0	40.0	-0.167	0.025	1000.0	-1000.0	-0.04	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	2.0	98.0	45.0	-0.059	0.055	1000.0	-1000.0	-0.084	-1000.0
TCGA08_rtk_signaling	2.0	67.0	26.0	-0.075	0.032	1000.0	-1000.0	-0.03	-1000.0
Class I PI3K signaling events	2.0	170.0	73.0	-0.046	0.043	1000.0	-1000.0	-0.07	-1000.0
PDGFR-beta signaling pathway	2.0	252.0	97.0	-0.137	0.05	1000.0	-1000.0	-0.081	-1000.0
a4b1 and a4b7 Integrin signaling	1.0	8.0	5.0	-0.007	-0.002	1000.0	-1000.0	-0.035	-1000.0
HIF-2-alpha transcription factor network	1.0	73.0	43.0	-0.083	0.097	1000.0	-1000.0	-0.098	-1000.0
Signaling events mediated by HDAC Class I	1.0	201.0	104.0	-0.143	0.0	1000.0	-1000.0	-0.068	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	55.0	36.0	-0.065	0.019	1000.0	-1000.0	-0.07	-1000.0
Atypical NF-kappaB pathway	1.0	47.0	31.0	-0.039	0.019	1000.0	-1000.0	-0.066	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	1.0	53.0	27.0	-0.062	0.0	1000.0	-1000.0	-0.05	-1000.0
p38 MAPK signaling pathway	1.0	54.0	44.0	-0.03	0.029	1000.0	-1000.0	-0.061	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	14.0	23.0	-0.012	0.032	1000.0	-1000.0	-0.068	-1000.0
Canonical NF-kappaB pathway	0.0	13.0	39.0	-0.016	0.066	1000.0	-1000.0	-0.083	-1000.0
Circadian rhythm pathway	0.0	14.0	22.0	-0.011	0.035	1000.0	-1000.0	-0.073	-1000.0
Arf6 downstream pathway	0.0	8.0	43.0	-0.013	0.018	1000.0	-1000.0	-0.046	-1000.0
EPO signaling pathway	0.0	22.0	55.0	-0.006	0.067	1000.0	-1000.0	-0.084	-1000.0
mTOR signaling pathway	0.0	17.0	53.0	-0.004	0.027	1000.0	-1000.0	-0.058	-1000.0
ceramide signaling pathway	0.0	19.0	49.0	-0.011	0.044	1000.0	-1000.0	-0.054	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	0.0	105.0	125.0	-0.034	0.079	1000.0	-1000.0	-0.103	-1000.0
VEGFR1 specific signals	0.0	35.0	56.0	-0.016	0.048	1000.0	-1000.0	-0.083	-1000.0
Arf1 pathway	0.0	7.0	54.0	-0.007	0.017	1000.0	-1000.0	-0.039	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.0	1000.0	-1000.0	-0.06	-1000.0
Total	1626	86106	7203	-25.3217092947	-995.462953865	131000	-131000	-9.26590177177	-131000