E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.091 0.22 -9999.0 0.0 -0.445 102.0 102.0 KLHL20 -0.002 0.089 -9999.0 0.0 -0.215 8.0 8.0 CYFIP2 -0.01 0.123 -9999.0 0.0 -0.537 19.0 19.0 Rac1/GDP -0.022 0.142 -9999.0 0.0 -0.25 100.0 100.0 ENAH -0.091 0.22 -9999.0 0.0 -0.445 102.0 102.0 AP1M1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.048 0.079 -9999.0 0.0 -0.24 7.0 7.0 ABI1/Sra1/Nap1 -0.032 0.046 -9999.0 0.0 -0.17 15.0 15.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.088 0.191 -9999.0 0.0 -0.325 135.0 135.0 RAPGEF1 -0.065 0.194 -9999.0 0.0 -0.377 102.0 102.0 CTNND1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.099 0.226 -9999.0 0.0 -0.464 102.0 102.0 CRK -0.078 0.208 -9999.0 0.0 -0.413 102.0 102.0 E-cadherin/gamma catenin/alpha catenin -0.064 0.161 -9999.0 0.0 -0.322 102.0 102.0 alphaE/beta7 Integrin -0.032 0.145 -9999.0 0.0 -0.382 54.0 54.0 IQGAP1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.027 0.035 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.09 0.22 -9999.0 0.0 -0.445 102.0 102.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.035 0.058 -9999.0 0.0 -0.173 8.0 8.0 MLLT4 0.001 0.066 -9999.0 0.0 -0.243 25.0 25.0 ARF6/GTP/NME1/Tiam1 0.017 0.077 -9999.0 0.0 -0.288 22.0 22.0 PI3K -0.044 0.072 -9999.0 0.0 -0.221 8.0 8.0 ARF6 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.09 0.186 -9999.0 0.0 -0.387 102.0 102.0 TIAM1 -0.014 0.132 -9999.0 0.0 -0.537 22.0 22.0 E-cadherin(dimer)/Ca2+ -0.04 0.138 -9999.0 0.0 -0.263 102.0 102.0 AKT1 -0.025 0.042 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.135 0.249 -9999.0 0.0 -0.537 102.0 102.0 RhoA/GDP -0.022 0.142 -9999.0 0.0 -0.251 100.0 100.0 actin cytoskeleton organization 0.0 0.068 -9999.0 0.0 -0.157 8.0 8.0 CDC42/GDP -0.022 0.142 -9999.0 0.0 -0.251 100.0 100.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.049 0.123 -9999.0 0.0 -0.246 102.0 102.0 ITGB7 -0.063 0.197 -9999.0 0.0 -0.537 54.0 54.0 RAC1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.042 0.147 -9999.0 0.0 -0.28 102.0 102.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.051 0.136 -9999.0 0.0 -0.27 102.0 102.0 mol:GDP -0.038 0.159 -9999.0 0.0 -0.294 102.0 102.0 CDC42/GTP/IQGAP1 0.026 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.011 0.045 -9999.0 0.0 -0.243 11.0 11.0 p120 catenin/RhoA/GDP -0.023 0.144 -9999.0 0.0 -0.254 100.0 100.0 RAC1/GTP/IQGAP1 0.026 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.028 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.003 0.05 -9999.0 0.0 -0.129 5.0 5.0 NME1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.09 0.22 -9999.0 0.0 -0.445 102.0 102.0 regulation of cell-cell adhesion -0.043 0.071 -9999.0 0.0 -0.212 7.0 7.0 WASF2 -0.016 0.025 -9999.0 0.0 -0.114 2.0 2.0 Rap1/GTP -0.016 0.116 -9999.0 0.0 -0.274 7.0 7.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.078 0.184 -9999.0 0.0 -0.304 135.0 135.0 CCND1 0.003 0.06 -9999.0 0.0 -0.157 5.0 5.0 VAV2 -0.073 0.215 -9999.0 0.0 -0.412 103.0 103.0 RAP1/GDP -0.019 0.125 -9999.0 0.0 -0.274 9.0 9.0 adherens junction assembly -0.087 0.213 -9999.0 0.0 -0.431 102.0 102.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.069 0.176 -9999.0 0.0 -0.285 135.0 135.0 E-cadherin/beta catenin -0.087 0.171 -9999.0 0.0 -0.362 102.0 102.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.09 0.22 -9999.0 0.0 -0.445 102.0 102.0 PIK3CA 0.018 0.014 -9999.0 0.0 -0.243 1.0 1.0 Rac1/GTP -0.066 0.095 -9999.0 0.0 -0.351 8.0 8.0 E-cadherin/beta catenin/alpha catenin -0.06 0.159 -9999.0 0.0 -0.317 102.0 102.0 ITGAE 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.102 0.231 -9999.0 0.0 -0.474 102.0 102.0