Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.027 0.122 -9999.0 0.0 -0.491 13.0 13.0 IHH 0.015 0.052 -9999.0 0.0 -0.239 10.0 10.0 SHH Np/Cholesterol/GAS1 0.017 0.035 -9999.0 0.0 -0.295 4.0 4.0 LRPAP1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.017 0.035 0.293 4.0 -9999.0 0.0 4.0 SMO/beta Arrestin2 0.039 0.093 -9999.0 0.0 -0.496 4.0 4.0 SMO 0.031 0.097 -9999.0 0.0 -0.527 4.0 4.0 AKT1 0.043 0.049 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.015 0.03 -9999.0 0.0 -0.243 5.0 5.0 ADRBK1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.031 0.096 -9999.0 0.0 -0.519 4.0 4.0 STIL 0.034 0.065 -9999.0 0.0 -0.394 3.0 3.0 DHH N/PTCH2 0.002 0.084 -9999.0 0.0 -0.382 12.0 12.0 DHH N/PTCH1 0.019 0.1 -9999.0 0.0 -0.323 16.0 16.0 PIK3CA 0.018 0.014 -9999.0 0.0 -0.243 1.0 1.0 DHH -0.011 0.108 -9999.0 0.0 -0.354 29.0 29.0 PTHLH 0.021 0.16 -9999.0 0.0 -0.793 9.0 9.0 determination of left/right symmetry 0.031 0.096 -9999.0 0.0 -0.519 4.0 4.0 PIK3R1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.021 0.158 -9999.0 0.0 -0.784 9.0 9.0 IHH N/Hhip 0.012 0.028 -9999.0 0.0 -0.183 1.0 1.0 DHH N/Hhip -0.007 0.077 -9999.0 0.0 -0.391 11.0 11.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.031 0.096 -9999.0 0.0 -0.519 4.0 4.0 pancreas development -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.017 0.032 -9999.0 0.0 -0.39 2.0 2.0 PI3K 0.028 0.009 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.013 0.053 -9999.0 0.0 -0.419 5.0 5.0 somite specification 0.031 0.096 -9999.0 0.0 -0.519 4.0 4.0 SHH Np/Cholesterol/PTCH1 0.03 0.069 -9999.0 0.0 -0.378 4.0 4.0 SHH Np/Cholesterol/PTCH2 0.017 0.03 -9999.0 0.0 -0.295 2.0 2.0 SHH Np/Cholesterol/Megalin -0.149 0.159 -9999.0 0.0 -0.297 196.0 196.0 SHH 0.011 0.023 -9999.0 0.0 -0.391 1.0 1.0 catabolic process 0.029 0.085 -9999.0 0.0 -0.361 9.0 9.0 SMO/Vitamin D3 0.035 0.081 -9999.0 0.0 -0.519 3.0 3.0 SHH Np/Cholesterol/Hhip 0.008 0.017 -9999.0 0.0 -0.302 1.0 1.0 LRP2 -0.278 0.277 -9999.0 0.0 -0.537 196.0 196.0 receptor-mediated endocytosis -0.084 0.149 -9999.0 0.0 -0.41 21.0 21.0 SHH Np/Cholesterol/BOC 0.019 0.023 -9999.0 0.0 -0.294 1.0 1.0 SHH Np/Cholesterol/CDO 0.02 0.018 -9999.0 0.0 -0.294 1.0 1.0 mesenchymal cell differentiation -0.007 0.017 0.3 1.0 -9999.0 0.0 1.0 mol:Vitamin D3 0.034 0.071 -9999.0 0.0 -0.379 4.0 4.0 IHH N/PTCH2 0.021 0.046 -9999.0 0.0 -0.272 3.0 3.0 CDON 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.032 0.086 -9999.0 0.0 -0.363 9.0 9.0 Megalin/LRPAP1 -0.191 0.204 -9999.0 0.0 -0.382 196.0 196.0 PTCH2 0.012 0.046 -9999.0 0.0 -0.28 8.0 8.0 SHH Np/Cholesterol 0.011 0.018 -9999.0 0.0 -0.302 1.0 1.0 PTCH1 0.029 0.085 -9999.0 0.0 -0.362 9.0 9.0 HHIP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0