Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.038 0.12 -9999.0 0.0 -0.232 102.0 102.0 epithelial cell differentiation -0.043 0.135 -9999.0 0.0 -0.261 102.0 102.0 CYFIP2 -0.01 0.123 -9999.0 0.0 -0.537 19.0 19.0 ENAH 0.004 0.095 -9999.0 0.0 -0.309 2.0 2.0 EGFR -0.007 0.086 -9999.0 0.0 -0.27 33.0 33.0 EPHA2 0.013 0.058 -9999.0 0.0 -0.537 4.0 4.0 MYO6 -0.039 0.128 -9999.0 0.0 -0.244 102.0 102.0 CTNNB1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.02 0.079 -9999.0 0.0 -0.317 19.0 19.0 AQP5 -0.044 0.119 -9999.0 0.0 -0.316 15.0 15.0 CTNND1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.038 0.125 -9999.0 0.0 -0.24 102.0 102.0 regulation of calcium-dependent cell-cell adhesion -0.046 0.132 -9999.0 0.0 -0.245 111.0 111.0 EGF -0.031 0.147 -9999.0 0.0 -0.422 41.0 41.0 NCKAP1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.086 0.205 -9999.0 0.0 -0.52 49.0 49.0 cortical microtubule organization -0.043 0.135 -9999.0 0.0 -0.261 102.0 102.0 GO:0000145 -0.038 0.119 -9999.0 0.0 -0.229 102.0 102.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.041 0.138 -9999.0 0.0 -0.263 102.0 102.0 MLLT4 0.001 0.066 -9999.0 0.0 -0.243 25.0 25.0 ARF6/GDP -0.055 0.09 -9999.0 0.0 -0.427 2.0 2.0 ARF6 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.045 0.034 -9999.0 0.0 -0.28 4.0 4.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.025 0.121 -9999.0 0.0 -0.288 2.0 2.0 PVRL2 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.039 0.128 -9999.0 0.0 -0.245 102.0 102.0 ARF6/GTP 0.05 0.032 -9999.0 0.0 -0.253 4.0 4.0 CDH1 -0.135 0.249 -9999.0 0.0 -0.537 102.0 102.0 EGFR/EGFR/EGF/EGF -0.092 0.133 -9999.0 0.0 -0.268 120.0 120.0 RhoA/GDP -0.037 0.127 -9999.0 0.0 -0.241 102.0 102.0 actin cytoskeleton organization -0.033 0.124 -9999.0 0.0 -0.233 102.0 102.0 IGF-1R heterotetramer 0.015 0.03 -9999.0 0.0 -0.243 5.0 5.0 GIT1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.015 0.03 -9999.0 0.0 -0.243 5.0 5.0 IGF1 0.009 0.066 -9999.0 0.0 -0.361 10.0 10.0 DIAPH1 -0.026 0.141 -9999.0 0.0 -0.626 19.0 19.0 Wnt receptor signaling pathway 0.043 0.135 0.261 102.0 -9999.0 0.0 102.0 RHOA 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.056 0.09 -9999.0 0.0 -0.428 2.0 2.0 CTNNA1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.034 0.127 -9999.0 0.0 -0.238 102.0 102.0 EFNA1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.031 0.121 -9999.0 0.0 -0.226 103.0 103.0 Ephrin A1/EPHA2 -0.066 0.107 -9999.0 0.0 -0.234 104.0 104.0 SEC6/SEC8 -0.061 0.095 -9999.0 0.0 -0.303 7.0 7.0 MGAT3 -0.047 0.134 -9999.0 0.0 -0.249 111.0 111.0 HGF/MET -0.089 0.137 -9999.0 0.0 -0.275 116.0 116.0 HGF 0.0 0.084 -9999.0 0.0 -0.336 19.0 19.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.038 0.121 -9999.0 0.0 -0.234 102.0 102.0 actin cable formation 0.02 0.097 -9999.0 0.0 -0.217 10.0 10.0 KIAA1543 -0.059 0.14 -9999.0 0.0 -0.253 116.0 116.0 KIFC3 -0.038 0.128 -9999.0 0.0 -0.244 102.0 102.0 NCK1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.018 0.014 -9999.0 0.0 -0.243 1.0 1.0 ACTN1 -0.039 0.127 -9999.0 0.0 -0.243 103.0 103.0 NCK1/GIT1 0.028 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.043 0.135 -9999.0 0.0 -0.261 102.0 102.0 EXOC4 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.038 0.127 -9999.0 0.0 -0.243 102.0 102.0 PIP5K1C -0.038 0.127 -9999.0 0.0 -0.243 102.0 102.0 LIMA1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.004 0.107 -9999.0 0.0 -0.37 2.0 2.0 adherens junction assembly -0.039 0.137 -9999.0 0.0 -0.358 20.0 20.0 IGF-1R heterotetramer/IGF1 -0.069 0.108 -9999.0 0.0 -0.237 105.0 105.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.016 0.045 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.025 0.141 -9999.0 0.0 -0.431 36.0 36.0 PLEKHA7 -0.049 0.137 -9999.0 0.0 -0.251 113.0 113.0 mol:GTP 0.043 0.034 -9999.0 0.0 -0.279 4.0 4.0 establishment of epithelial cell apical/basal polarity -0.015 0.117 -9999.0 0.0 -0.287 7.0 7.0 cortical actin cytoskeleton stabilization -0.038 0.12 -9999.0 0.0 -0.232 102.0 102.0 regulation of cell-cell adhesion -0.033 0.124 -9999.0 0.0 -0.233 102.0 102.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.038 0.121 -9999.0 0.0 -0.234 102.0 102.0