Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
BCR signaling pathway	139.0	13775.0	99.0	-0.764	0.026	1000.0	-1000.0	-0.053	-1000.0
IL4-mediated signaling events	132.0	12062.0	91.0	-1.305	1.04	1000.0	-1000.0	-0.106	-1000.0
TCR signaling in naïve CD8+ T cells	104.0	9728.0	93.0	-0.589	0.028	1000.0	-1000.0	-0.045	-1000.0
IL23-mediated signaling events	101.0	6111.0	60.0	-0.738	0.019	1000.0	-1000.0	-0.066	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	92.0	3131.0	34.0	-0.211	0.019	1000.0	-1000.0	-0.022	-1000.0
IL12-mediated signaling events	80.0	7018.0	87.0	-0.677	0.114	1000.0	-1000.0	-0.092	-1000.0
Caspase cascade in apoptosis	69.0	5108.0	74.0	-0.207	0.136	1000.0	-1000.0	-0.026	-1000.0
FAS signaling pathway (CD95)	69.0	3269.0	47.0	-0.162	0.121	1000.0	-1000.0	-0.012	-1000.0
E-cadherin signaling events	63.0	317.0	5.0	-0.135	0.019	1000.0	-1000.0	-0.001	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	61.0	4172.0	68.0	-0.626	0.119	1000.0	-1000.0	-0.059	-1000.0
Calcium signaling in the CD4+ TCR pathway	58.0	1807.0	31.0	-0.433	0.019	1000.0	-1000.0	-0.052	-1000.0
JNK signaling in the CD4+ TCR pathway	56.0	964.0	17.0	-0.202	0.019	1000.0	-1000.0	-0.017	-1000.0
Ras signaling in the CD4+ TCR pathway	56.0	960.0	17.0	-0.166	0.037	1000.0	-1000.0	-0.008	-1000.0
IL27-mediated signaling events	53.0	2705.0	51.0	-0.264	0.167	1000.0	-1000.0	-0.051	-1000.0
S1P4 pathway	53.0	1330.0	25.0	-0.164	0.028	1000.0	-1000.0	-0.009	-1000.0
Glypican 1 network	50.0	2415.0	48.0	-0.298	0.069	1000.0	-1000.0	-0.019	-1000.0
Signaling events regulated by Ret tyrosine kinase	49.0	4080.0	82.0	-0.128	0.019	1000.0	-1000.0	-0.052	-1000.0
Wnt signaling	49.0	344.0	7.0	-0.081	0.008	1000.0	-1000.0	-0.005	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	48.0	3610.0	74.0	-0.135	0.05	1000.0	-1000.0	-0.048	-1000.0
a4b1 and a4b7 Integrin signaling	45.0	225.0	5.0	-0.076	-0.02	1000.0	-1000.0	-0.005	-1000.0
amb2 Integrin signaling	45.0	3733.0	82.0	-0.27	0.026	1000.0	-1000.0	-0.03	-1000.0
Endothelins	44.0	4283.0	96.0	-0.178	0.02	1000.0	-1000.0	-0.04	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	44.0	2008.0	45.0	-0.274	0.045	1000.0	-1000.0	-0.052	-1000.0
Glucocorticoid receptor regulatory network	43.0	4962.0	114.0	-0.519	0.309	1000.0	-1000.0	-0.04	-1000.0
E-cadherin signaling in the nascent adherens junction	42.0	3253.0	76.0	-0.135	0.028	1000.0	-1000.0	-0.05	-1000.0
TCGA08_retinoblastoma	41.0	333.0	8.0	-0.107	0.03	1000.0	-1000.0	-0.002	-1000.0
Syndecan-4-mediated signaling events	40.0	2684.0	67.0	-0.256	0.025	1000.0	-1000.0	-0.018	-1000.0
Angiopoietin receptor Tie2-mediated signaling	40.0	3560.0	88.0	-0.228	0.031	1000.0	-1000.0	-0.051	-1000.0
IL2 signaling events mediated by PI3K	39.0	2266.0	58.0	-0.193	0.046	1000.0	-1000.0	-0.025	-1000.0
IL2 signaling events mediated by STAT5	39.0	858.0	22.0	-0.195	0.02	1000.0	-1000.0	-0.018	-1000.0
Syndecan-1-mediated signaling events	38.0	1306.0	34.0	-0.147	0.019	1000.0	-1000.0	-0.017	-1000.0
Thromboxane A2 receptor signaling	37.0	3968.0	105.0	-0.123	0.041	1000.0	-1000.0	-0.044	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	37.0	1402.0	37.0	-0.293	0.041	1000.0	-1000.0	-0.014	-1000.0
Regulation of p38-alpha and p38-beta	36.0	1985.0	54.0	-0.339	0.049	1000.0	-1000.0	-0.038	-1000.0
LPA receptor mediated events	36.0	3769.0	102.0	-0.131	0.025	1000.0	-1000.0	-0.058	-1000.0
Class I PI3K signaling events	35.0	2556.0	73.0	-0.448	0.048	1000.0	-1000.0	-0.024	-1000.0
E-cadherin signaling in keratinocytes	34.0	1468.0	43.0	-0.135	0.022	1000.0	-1000.0	-0.014	-1000.0
HIF-1-alpha transcription factor network	32.0	2455.0	76.0	-0.114	0.084	1000.0	-1000.0	-0.05	-1000.0
Fc-epsilon receptor I signaling in mast cells	31.0	3029.0	97.0	-0.134	0.033	1000.0	-1000.0	-0.053	-1000.0
Ephrin A  reverse signaling	30.0	213.0	7.0	-0.07	0.008	1000.0	-1000.0	-0.004	-1000.0
Visual signal transduction: Cones	28.0	1088.0	38.0	-0.208	0.017	1000.0	-1000.0	-0.006	-1000.0
TRAIL signaling pathway	27.0	1310.0	48.0	-0.058	0.021	1000.0	-1000.0	-0.028	-1000.0
ceramide signaling pathway	27.0	1323.0	49.0	-0.176	0.028	1000.0	-1000.0	-0.021	-1000.0
Visual signal transduction: Rods	27.0	1454.0	52.0	-0.208	0.019	1000.0	-1000.0	-0.045	-1000.0
Atypical NF-kappaB pathway	26.0	810.0	31.0	-0.196	0.033	1000.0	-1000.0	-0.01	-1000.0
Osteopontin-mediated events	25.0	950.0	38.0	-0.049	0.034	1000.0	-1000.0	-0.013	-1000.0
Noncanonical Wnt signaling pathway	25.0	674.0	26.0	-0.081	0.019	1000.0	-1000.0	-0.017	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	25.0	1300.0	52.0	-0.192	0.031	1000.0	-1000.0	-0.018	-1000.0
TCGA08_p53	25.0	179.0	7.0	-0.071	0.051	1000.0	-1000.0	-0.004	-1000.0
BMP receptor signaling	24.0	1989.0	81.0	-0.229	0.059	1000.0	-1000.0	-0.057	-1000.0
Sphingosine 1-phosphate (S1P) pathway	23.0	660.0	28.0	-0.164	0.049	1000.0	-1000.0	-0.011	-1000.0
Aurora C signaling	22.0	156.0	7.0	-0.097	0.017	1000.0	-1000.0	-0.006	-1000.0
FOXA2 and FOXA3 transcription factor networks	22.0	1050.0	46.0	-0.503	0.027	1000.0	-1000.0	-0.033	-1000.0
IFN-gamma pathway	22.0	1560.0	68.0	-0.179	0.028	1000.0	-1000.0	-0.057	-1000.0
IL6-mediated signaling events	21.0	1633.0	75.0	-0.188	0.068	1000.0	-1000.0	-0.025	-1000.0
Arf6 signaling events	20.0	1284.0	62.0	-0.174	0.045	1000.0	-1000.0	-0.018	-1000.0
Signaling events mediated by PTP1B	20.0	1565.0	76.0	-0.339	0.032	1000.0	-1000.0	-0.031	-1000.0
Paxillin-dependent events mediated by a4b1	20.0	746.0	36.0	-0.076	0.059	1000.0	-1000.0	-0.026	-1000.0
Integrins in angiogenesis	20.0	1757.0	84.0	-0.199	0.043	1000.0	-1000.0	-0.048	-1000.0
Syndecan-2-mediated signaling events	19.0	1329.0	69.0	-0.256	0.046	1000.0	-1000.0	-0.009	-1000.0
p75(NTR)-mediated signaling	19.0	2460.0	125.0	-0.176	0.054	1000.0	-1000.0	-0.053	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	17.0	1387.0	78.0	-0.148	0.055	1000.0	-1000.0	-0.035	-1000.0
EPO signaling pathway	16.0	912.0	55.0	-0.079	0.029	1000.0	-1000.0	-0.05	-1000.0
Effects of Botulinum toxin	16.0	436.0	26.0	-0.066	0.025	1000.0	-1000.0	-0.009	-1000.0
EGFR-dependent Endothelin signaling events	16.0	353.0	21.0	-0.031	0.028	1000.0	-1000.0	-0.038	-1000.0
Signaling events mediated by the Hedgehog family	15.0	824.0	52.0	-0.278	0.043	1000.0	-1000.0	-0.022	-1000.0
Cellular roles of Anthrax toxin	15.0	615.0	39.0	-0.147	0.019	1000.0	-1000.0	-0.01	-1000.0
Ceramide signaling pathway	15.0	1184.0	76.0	-0.176	0.042	1000.0	-1000.0	-0.016	-1000.0
EPHB forward signaling	15.0	1297.0	85.0	-0.059	0.04	1000.0	-1000.0	-0.05	-1000.0
Nectin adhesion pathway	14.0	920.0	63.0	-0.242	0.046	1000.0	-1000.0	-0.05	-1000.0
S1P5 pathway	14.0	254.0	17.0	-0.093	0.019	1000.0	-1000.0	-0.007	-1000.0
Plasma membrane estrogen receptor signaling	14.0	1277.0	86.0	-0.093	0.048	1000.0	-1000.0	-0.052	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	13.0	1154.0	85.0	-0.075	0.041	1000.0	-1000.0	-0.043	-1000.0
Ephrin B reverse signaling	13.0	638.0	48.0	-0.119	0.021	1000.0	-1000.0	-0.035	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	13.0	1108.0	83.0	-0.158	0.084	1000.0	-1000.0	-0.027	-1000.0
Nongenotropic Androgen signaling	13.0	693.0	52.0	-0.093	0.037	1000.0	-1000.0	-0.026	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	13.0	1643.0	120.0	-0.115	0.078	1000.0	-1000.0	-0.042	-1000.0
LPA4-mediated signaling events	12.0	155.0	12.0	-0.056	0.02	1000.0	-1000.0	-0.008	-1000.0
Reelin signaling pathway	12.0	675.0	56.0	-0.105	0.052	1000.0	-1000.0	-0.049	-1000.0
IL1-mediated signaling events	12.0	746.0	62.0	-0.069	0.07	1000.0	-1000.0	-0.051	-1000.0
Coregulation of Androgen receptor activity	11.0	865.0	76.0	-0.107	0.038	1000.0	-1000.0	-0.023	-1000.0
Syndecan-3-mediated signaling events	11.0	412.0	35.0	-0.054	0.054	1000.0	-1000.0	-0.025	-1000.0
Glypican 2 network	11.0	47.0	4.0	0.004	0.01	1000.0	-1000.0	-0.004	-1000.0
S1P3 pathway	11.0	488.0	42.0	-0.091	0.037	1000.0	-1000.0	-0.018	-1000.0
ErbB2/ErbB3 signaling events	10.0	652.0	65.0	-0.023	0.042	1000.0	-1000.0	-0.039	-1000.0
ErbB4 signaling events	10.0	750.0	69.0	-0.122	0.052	1000.0	-1000.0	-0.046	-1000.0
Presenilin action in Notch and Wnt signaling	10.0	619.0	61.0	-0.11	0.055	1000.0	-1000.0	-0.024	-1000.0
S1P1 pathway	10.0	376.0	36.0	-0.093	0.021	1000.0	-1000.0	-0.036	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	9.0	497.0	54.0	-0.128	0.033	1000.0	-1000.0	-0.054	-1000.0
Canonical Wnt signaling pathway	9.0	509.0	51.0	-0.078	0.071	1000.0	-1000.0	-0.03	-1000.0
PDGFR-beta signaling pathway	9.0	926.0	97.0	-0.341	0.061	1000.0	-1000.0	-0.045	-1000.0
Regulation of Androgen receptor activity	9.0	668.0	70.0	-0.139	0.056	1000.0	-1000.0	-0.036	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	8.0	269.0	33.0	-0.107	0.055	1000.0	-1000.0	-0.013	-1000.0
Rapid glucocorticoid signaling	8.0	170.0	20.0	-0.02	0.02	1000.0	-1000.0	-0.004	-1000.0
Regulation of nuclear SMAD2/3 signaling	7.0	1078.0	136.0	-0.107	0.081	1000.0	-1000.0	-0.021	-1000.0
TCGA08_rtk_signaling	7.0	182.0	26.0	-0.055	0.05	1000.0	-1000.0	-0.006	-1000.0
Aurora B signaling	7.0	475.0	67.0	-0.147	0.057	1000.0	-1000.0	-0.028	-1000.0
Signaling events mediated by HDAC Class I	6.0	668.0	104.0	-0.095	0.063	1000.0	-1000.0	-0.027	-1000.0
Signaling mediated by p38-gamma and p38-delta	6.0	103.0	15.0	-0.03	0.027	1000.0	-1000.0	-0.011	-1000.0
Signaling mediated by p38-alpha and p38-beta	6.0	267.0	44.0	-0.038	0.028	1000.0	-1000.0	-0.018	-1000.0
Regulation of Telomerase	6.0	713.0	102.0	-0.173	0.069	1000.0	-1000.0	-0.062	-1000.0
Insulin Pathway	6.0	448.0	74.0	-0.061	0.048	1000.0	-1000.0	-0.049	-1000.0
Class IB PI3K non-lipid kinase events	6.0	18.0	3.0	-0.01	0.01	1000.0	-1000.0	-0.002	-1000.0
Canonical NF-kappaB pathway	5.0	232.0	39.0	-0.095	0.085	1000.0	-1000.0	-0.045	-1000.0
Hedgehog signaling events mediated by Gli proteins	5.0	373.0	65.0	-0.092	0.085	1000.0	-1000.0	-0.042	-1000.0
PDGFR-alpha signaling pathway	5.0	225.0	44.0	-0.013	0.041	1000.0	-1000.0	-0.01	-1000.0
Signaling events mediated by PRL	5.0	174.0	34.0	-0.089	0.049	1000.0	-1000.0	-0.022	-1000.0
FOXM1 transcription factor network	5.0	273.0	51.0	-0.115	0.288	1000.0	-1000.0	-0.1	-1000.0
Signaling events mediated by HDAC Class III	4.0	196.0	40.0	-0.093	0.035	1000.0	-1000.0	-0.008	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	4.0	576.0	125.0	-0.12	0.083	1000.0	-1000.0	-0.052	-1000.0
Insulin-mediated glucose transport	3.0	119.0	32.0	-0.035	0.05	1000.0	-1000.0	-0.015	-1000.0
FoxO family signaling	3.0	201.0	64.0	-0.429	0.175	1000.0	-1000.0	-0.022	-1000.0
Retinoic acid receptors-mediated signaling	3.0	200.0	58.0	-0.051	0.057	1000.0	-1000.0	-0.041	-1000.0
p38 MAPK signaling pathway	3.0	152.0	44.0	-0.045	0.042	1000.0	-1000.0	-0.046	-1000.0
Signaling events mediated by HDAC Class II	2.0	179.0	75.0	-0.064	0.054	1000.0	-1000.0	-0.028	-1000.0
Arf6 downstream pathway	2.0	94.0	43.0	-0.031	0.036	1000.0	-1000.0	-0.013	-1000.0
IGF1 pathway	2.0	118.0	57.0	-0.046	0.054	1000.0	-1000.0	-0.054	-1000.0
VEGFR1 specific signals	2.0	167.0	56.0	-0.052	0.064	1000.0	-1000.0	-0.021	-1000.0
Aurora A signaling	1.0	103.0	60.0	-0.023	0.052	1000.0	-1000.0	-0.013	-1000.0
Class I PI3K signaling events mediated by Akt	1.0	90.0	68.0	-0.044	0.059	1000.0	-1000.0	-0.018	-1000.0
HIF-2-alpha transcription factor network	1.0	83.0	43.0	-0.162	0.165	1000.0	-1000.0	-0.046	-1000.0
Arf6 trafficking events	1.0	119.0	71.0	-0.028	0.049	1000.0	-1000.0	-0.031	-1000.0
Arf1 pathway	1.0	105.0	54.0	-0.034	0.034	1000.0	-1000.0	-0.011	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	0.0	23.0	0.015	0.056	1000.0	-1000.0	-0.014	-1000.0
BARD1 signaling events	0.0	25.0	57.0	-0.046	0.079	1000.0	-1000.0	-0.02	-1000.0
PLK2 and PLK4 events	0.0	2.0	3.0	0.017	0.025	1000.0	-1000.0	-0.006	-1000.0
Circadian rhythm pathway	0.0	12.0	22.0	-0.016	0.06	1000.0	-1000.0	-0.026	-1000.0
PLK1 signaling events	0.0	48.0	85.0	-0.012	0.05	1000.0	-1000.0	-0.022	-1000.0
mTOR signaling pathway	0.0	19.0	53.0	-0.005	0.041	1000.0	-1000.0	-0.036	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	10.0	27.0	-0.001	0.046	1000.0	-1000.0	-0.033	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	-0.0	0.056	1000.0	-1000.0	-0.005	-1000.0
Total	3196	189865	7203	-21.5062171788	7.57199169165	131000	-131000	-3.97048346483	-131000