E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.003 0.083 -9999.0 0.0 -0.351 22.0 22.0 KLHL20 0.024 0.065 0.168 21.0 -0.225 4.0 25.0 CYFIP2 0.008 0.081 -9999.0 0.0 -0.372 26.0 26.0 Rac1/GDP 0.033 0.083 0.265 16.0 -0.285 1.0 17.0 ENAH 0.0 0.09 -9999.0 0.0 -0.349 26.0 26.0 AP1M1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.014 0.037 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.011 0.03 -9999.0 0.0 -0.154 7.0 7.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.054 0.042 -9999.0 0.0 -0.202 9.0 9.0 RAPGEF1 0.013 0.097 0.231 10.0 -0.349 11.0 21.0 CTNND1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.004 0.101 -9999.0 0.0 -0.35 32.0 32.0 CRK 0.012 0.094 -9999.0 0.0 -0.337 22.0 22.0 E-cadherin/gamma catenin/alpha catenin 0.038 0.047 -9999.0 0.0 -0.207 17.0 17.0 alphaE/beta7 Integrin 0.037 0.016 -9999.0 0.0 -0.263 1.0 1.0 IQGAP1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.046 0.017 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 0.002 0.084 -9999.0 0.0 -0.352 23.0 23.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 0.001 0.021 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.036 0.05 -9999.0 0.0 -0.179 27.0 27.0 PI3K 0.004 0.028 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.027 0.049 -9999.0 0.0 -0.247 17.0 17.0 TIAM1 0.009 0.076 -9999.0 0.0 -0.34 27.0 27.0 E-cadherin(dimer)/Ca2+ 0.051 0.038 -9999.0 0.0 -0.187 9.0 9.0 AKT1 0.005 0.037 0.145 4.0 -9999.0 0.0 4.0 PIK3R1 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.019 0.052 -9999.0 0.0 -0.373 10.0 10.0 RhoA/GDP 0.039 0.084 0.266 19.0 -0.285 1.0 20.0 actin cytoskeleton organization 0.022 0.054 0.148 28.0 -0.17 3.0 31.0 CDC42/GDP 0.037 0.086 0.266 19.0 -0.285 1.0 20.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.011 0.033 -9999.0 0.0 -0.205 10.0 10.0 ITGB7 0.026 0.017 -9999.0 0.0 -0.373 1.0 1.0 RAC1 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.055 0.041 -9999.0 0.0 -0.2 9.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.038 0.032 -9999.0 0.0 -0.184 9.0 9.0 mol:GDP 0.025 0.092 0.272 19.0 -0.327 1.0 20.0 CDC42/GTP/IQGAP1 0.033 0.011 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.021 0.038 -9999.0 0.0 -0.323 7.0 7.0 p120 catenin/RhoA/GDP 0.046 0.084 0.272 18.0 -9999.0 0.0 18.0 RAC1/GTP/IQGAP1 0.032 0.012 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.038 0.01 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.017 0.037 0.128 15.0 -0.14 1.0 16.0 NME1 0.026 0.015 -9999.0 0.0 -0.323 1.0 1.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.001 0.093 -9999.0 0.0 -0.346 29.0 29.0 regulation of cell-cell adhesion 0.008 0.03 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.009 0.027 0.084 1.0 -9999.0 0.0 1.0 Rap1/GTP 0.033 0.063 0.287 5.0 -9999.0 0.0 5.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.056 0.053 -9999.0 0.0 -0.192 9.0 9.0 CCND1 0.019 0.043 0.146 15.0 -0.171 1.0 16.0 VAV2 0.02 0.12 -9999.0 0.0 -0.494 8.0 8.0 RAP1/GDP 0.043 0.077 0.274 15.0 -9999.0 0.0 15.0 adherens junction assembly -0.0 0.091 -9999.0 0.0 -0.336 29.0 29.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.051 0.056 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin 0.005 0.042 -9999.0 0.0 -0.267 13.0 13.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.003 0.092 -9999.0 0.0 -0.346 29.0 29.0 PIK3CA 0.024 0.009 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.008 0.066 -9999.0 0.0 -0.331 7.0 7.0 E-cadherin/beta catenin/alpha catenin 0.043 0.038 -9999.0 0.0 -0.219 9.0 9.0 ITGAE 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.003 0.102 -9999.0 0.0 -0.357 32.0 32.0