Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.065 0.171 -9999.0 0.0 -0.439 76.0 76.0 IHH -0.068 0.183 -9999.0 0.0 -0.425 119.0 119.0 SHH Np/Cholesterol/GAS1 -0.026 0.099 -9999.0 0.0 -0.213 124.0 124.0 LRPAP1 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.026 0.099 0.212 124.0 -9999.0 0.0 124.0 SMO/beta Arrestin2 -0.068 0.189 0.266 1.0 -0.456 81.0 82.0 SMO -0.081 0.188 -9999.0 0.0 -0.471 84.0 84.0 AKT1 -0.039 0.143 -9999.0 0.0 -0.496 34.0 34.0 ARRB2 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.015 0.121 -9999.0 0.0 -0.373 61.0 61.0 ADRBK1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.08 0.186 -9999.0 0.0 -0.462 85.0 85.0 STIL -0.075 0.15 0.356 1.0 -0.373 85.0 86.0 DHH N/PTCH2 0.004 0.093 -9999.0 0.0 -0.243 73.0 73.0 DHH N/PTCH1 -0.046 0.152 -9999.0 0.0 -0.355 80.0 80.0 PIK3CA 0.024 0.009 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.009 0.082 -9999.0 0.0 -0.373 26.0 26.0 PTHLH -0.102 0.244 -9999.0 0.0 -0.642 81.0 81.0 determination of left/right symmetry -0.08 0.186 -9999.0 0.0 -0.462 85.0 85.0 PIK3R1 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.101 0.241 -9999.0 0.0 -0.636 81.0 81.0 IHH N/Hhip -0.108 0.185 -9999.0 0.0 -0.324 234.0 234.0 DHH N/Hhip -0.06 0.149 -9999.0 0.0 -0.278 184.0 184.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.08 0.186 -9999.0 0.0 -0.462 85.0 85.0 pancreas development -0.09 0.18 -9999.0 0.0 -0.373 172.0 172.0 HHAT 0.019 0.052 -9999.0 0.0 -0.373 10.0 10.0 PI3K 0.032 0.016 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.011 0.115 -9999.0 0.0 -0.367 56.0 56.0 somite specification -0.08 0.186 -9999.0 0.0 -0.462 85.0 85.0 SHH Np/Cholesterol/PTCH1 -0.062 0.152 -9999.0 0.0 -0.367 89.0 89.0 SHH Np/Cholesterol/PTCH2 -0.023 0.094 -9999.0 0.0 -0.201 123.0 123.0 SHH Np/Cholesterol/Megalin -0.025 0.094 -9999.0 0.0 -0.196 131.0 131.0 SHH -0.028 0.098 -9999.0 0.0 -0.273 80.0 80.0 catabolic process -0.055 0.152 -9999.0 0.0 -0.368 80.0 80.0 SMO/Vitamin D3 -0.073 0.178 -9999.0 0.0 -0.445 81.0 81.0 SHH Np/Cholesterol/Hhip -0.066 0.132 -9999.0 0.0 -0.24 201.0 201.0 LRP2 -0.011 0.106 -9999.0 0.0 -0.323 61.0 61.0 receptor-mediated endocytosis -0.084 0.172 -9999.0 0.0 -0.436 83.0 83.0 SHH Np/Cholesterol/BOC -0.027 0.102 -9999.0 0.0 -0.216 123.0 123.0 SHH Np/Cholesterol/CDO -0.012 0.085 -9999.0 0.0 -0.208 90.0 90.0 mesenchymal cell differentiation 0.066 0.131 0.239 201.0 -9999.0 0.0 201.0 mol:Vitamin D3 -0.06 0.156 -9999.0 0.0 -0.39 77.0 77.0 IHH N/PTCH2 -0.045 0.133 -9999.0 0.0 -0.255 161.0 161.0 CDON 0.018 0.052 -9999.0 0.0 -0.36 11.0 11.0 IHH N/PTCH1 -0.05 0.157 -9999.0 0.0 -0.371 80.0 80.0 Megalin/LRPAP1 0.009 0.079 -9999.0 0.0 -0.223 61.0 61.0 PTCH2 -0.002 0.097 -9999.0 0.0 -0.328 48.0 48.0 SHH Np/Cholesterol -0.015 0.077 -9999.0 0.0 -0.205 81.0 81.0 PTCH1 -0.055 0.152 -9999.0 0.0 -0.369 80.0 80.0 HHIP -0.09 0.181 -9999.0 0.0 -0.373 172.0 172.0