Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.018 0.03 -9999.0 0.0 -0.202 9.0 9.0 epithelial cell differentiation 0.046 0.036 -9999.0 0.0 -0.186 9.0 9.0 CYFIP2 0.008 0.081 -9999.0 0.0 -0.372 26.0 26.0 ENAH -0.003 0.053 0.216 8.0 -9999.0 0.0 8.0 EGFR 0.017 0.052 -9999.0 0.0 -0.36 11.0 11.0 EPHA2 0.024 0.029 -9999.0 0.0 -0.323 4.0 4.0 MYO6 -0.005 0.043 0.179 21.0 -9999.0 0.0 21.0 CTNNB1 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.038 0.056 -9999.0 0.0 -0.221 24.0 24.0 AQP5 -0.087 0.162 0.208 1.0 -0.416 98.0 99.0 CTNND1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.006 0.04 0.176 19.0 -9999.0 0.0 19.0 regulation of calcium-dependent cell-cell adhesion -0.013 0.051 0.179 17.0 -0.316 1.0 18.0 EGF -0.031 0.128 -9999.0 0.0 -0.325 94.0 94.0 NCKAP1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.008 0.081 0.208 1.0 -0.417 14.0 15.0 cortical microtubule organization 0.046 0.036 -9999.0 0.0 -0.186 9.0 9.0 GO:0000145 -0.006 0.038 0.165 18.0 -9999.0 0.0 18.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.051 0.038 -9999.0 0.0 -0.187 9.0 9.0 MLLT4 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.019 0.023 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.058 0.031 -9999.0 0.0 -0.172 4.0 4.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.004 0.033 0.174 12.0 -9999.0 0.0 12.0 PVRL2 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.006 0.042 0.178 20.0 -9999.0 0.0 20.0 ARF6/GTP 0.062 0.035 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.019 0.052 -9999.0 0.0 -0.373 10.0 10.0 EGFR/EGFR/EGF/EGF 0.007 0.076 -9999.0 0.0 -0.327 2.0 2.0 RhoA/GDP 0.046 0.036 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.006 0.039 0.166 21.0 -9999.0 0.0 21.0 IGF-1R heterotetramer 0.024 0.024 -9999.0 0.0 -0.373 2.0 2.0 GIT1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.024 0.024 -9999.0 0.0 -0.373 2.0 2.0 IGF1 -0.021 0.127 -9999.0 0.0 -0.358 74.0 74.0 DIAPH1 -0.001 0.168 -9999.0 0.0 -0.532 36.0 36.0 Wnt receptor signaling pathway -0.046 0.036 0.186 9.0 -9999.0 0.0 9.0 RHOA 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.019 0.023 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.007 0.04 0.168 21.0 -9999.0 0.0 21.0 EFNA1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.01 0.037 0.17 12.0 -0.287 1.0 13.0 Ephrin A1/EPHA2 0.038 0.037 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 -0.016 0.021 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.013 0.051 0.18 17.0 -0.321 1.0 18.0 HGF/MET 0.027 0.057 -9999.0 0.0 -0.313 1.0 1.0 HGF 0.011 0.074 -9999.0 0.0 -0.358 23.0 23.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.018 0.031 -9999.0 0.0 -0.203 9.0 9.0 actin cable formation 0.024 0.082 0.241 37.0 -0.297 2.0 39.0 KIAA1543 -0.007 0.042 0.168 20.0 -9999.0 0.0 20.0 KIFC3 -0.008 0.038 0.178 15.0 -9999.0 0.0 15.0 NCK1 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.024 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.007 0.042 0.178 19.0 -9999.0 0.0 19.0 NCK1/GIT1 0.036 0.012 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.046 0.036 -9999.0 0.0 -0.186 9.0 9.0 EXOC4 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.006 0.041 0.178 19.0 -9999.0 0.0 19.0 PIP5K1C -0.006 0.041 0.178 19.0 -9999.0 0.0 19.0 LIMA1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.004 0.066 0.246 14.0 -9999.0 0.0 14.0 adherens junction assembly -0.008 0.083 0.258 4.0 -0.588 6.0 10.0 IGF-1R heterotetramer/IGF1 0.014 0.076 -9999.0 0.0 -0.32 3.0 3.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.037 0.012 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.018 0.05 -9999.0 0.0 -0.327 12.0 12.0 PLEKHA7 -0.007 0.044 0.18 20.0 -9999.0 0.0 20.0 mol:GTP 0.056 0.031 -9999.0 0.0 -0.171 4.0 4.0 establishment of epithelial cell apical/basal polarity 0.02 0.087 0.299 24.0 -9999.0 0.0 24.0 cortical actin cytoskeleton stabilization 0.018 0.03 -9999.0 0.0 -0.202 9.0 9.0 regulation of cell-cell adhesion -0.006 0.039 0.166 21.0 -9999.0 0.0 21.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.018 0.031 -9999.0 0.0 -0.203 9.0 9.0