Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
FOXA2 and FOXA3 transcription factor networks	139.0	6425.0	46.0	-0.831	0.03	1000.0	-1000.0	-0.142	-1000.0
Reelin signaling pathway	137.0	7699.0	56.0	-0.217	0.063	1000.0	-1000.0	-0.044	-1000.0
Signaling events regulated by Ret tyrosine kinase	85.0	7013.0	82.0	-0.133	0.027	1000.0	-1000.0	-0.059	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	83.0	6492.0	78.0	-0.267	0.085	1000.0	-1000.0	-0.072	-1000.0
Signaling events mediated by the Hedgehog family	81.0	4241.0	52.0	-0.108	0.066	1000.0	-1000.0	-0.043	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	77.0	4174.0	54.0	-0.172	0.037	1000.0	-1000.0	-0.042	-1000.0
Glypican 1 network	74.0	3584.0	48.0	-0.123	0.033	1000.0	-1000.0	-0.038	-1000.0
Effects of Botulinum toxin	73.0	1916.0	26.0	-0.132	0.026	1000.0	-1000.0	-0.011	-1000.0
p75(NTR)-mediated signaling	67.0	8395.0	125.0	-0.166	0.069	1000.0	-1000.0	-0.064	-1000.0
Glypican 2 network	63.0	253.0	4.0	-0.002	-0.002	1000.0	-1000.0	0.011	-1000.0
Wnt signaling	61.0	432.0	7.0	-0.053	-0.004	1000.0	-1000.0	-0.016	-1000.0
HIF-1-alpha transcription factor network	57.0	4333.0	76.0	-0.339	0.035	1000.0	-1000.0	-0.162	-1000.0
IL4-mediated signaling events	57.0	5259.0	91.0	-0.673	0.514	1000.0	-1000.0	-0.187	-1000.0
Visual signal transduction: Cones	53.0	2016.0	38.0	-0.062	0.046	1000.0	-1000.0	-0.016	-1000.0
Fc-epsilon receptor I signaling in mast cells	52.0	5073.0	97.0	-0.109	0.039	1000.0	-1000.0	-0.059	-1000.0
Ephrin B reverse signaling	50.0	2402.0	48.0	-0.113	0.054	1000.0	-1000.0	-0.037	-1000.0
Syndecan-1-mediated signaling events	46.0	1585.0	34.0	-0.12	0.026	1000.0	-1000.0	-0.047	-1000.0
Ephrin A  reverse signaling	46.0	328.0	7.0	-0.012	0.01	1000.0	-1000.0	-0.013	-1000.0
amb2 Integrin signaling	46.0	3801.0	82.0	-0.161	0.037	1000.0	-1000.0	-0.039	-1000.0
Nongenotropic Androgen signaling	46.0	2424.0	52.0	-0.075	0.039	1000.0	-1000.0	-0.045	-1000.0
BMP receptor signaling	45.0	3691.0	81.0	-0.138	0.048	1000.0	-1000.0	-0.061	-1000.0
Syndecan-2-mediated signaling events	43.0	2993.0	69.0	-0.152	0.042	1000.0	-1000.0	-0.044	-1000.0
Canonical Wnt signaling pathway	43.0	2207.0	51.0	-0.132	0.129	1000.0	-1000.0	-0.048	-1000.0
Noncanonical Wnt signaling pathway	41.0	1073.0	26.0	-0.053	0.026	1000.0	-1000.0	-0.044	-1000.0
EPHB forward signaling	41.0	3540.0	85.0	-0.115	0.096	1000.0	-1000.0	-0.067	-1000.0
TCGA08_retinoblastoma	41.0	333.0	8.0	-0.069	0.045	1000.0	-1000.0	-0.007	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	37.0	4493.0	120.0	-0.113	0.078	1000.0	-1000.0	-0.051	-1000.0
TCGA08_p53	36.0	257.0	7.0	-0.054	0.036	1000.0	-1000.0	-0.009	-1000.0
TCR signaling in naïve CD8+ T cells	36.0	3362.0	93.0	-0.103	0.05	1000.0	-1000.0	-0.047	-1000.0
BCR signaling pathway	36.0	3616.0	99.0	-0.09	0.034	1000.0	-1000.0	-0.053	-1000.0
Visual signal transduction: Rods	35.0	1861.0	52.0	-0.046	0.027	1000.0	-1000.0	-0.039	-1000.0
LPA receptor mediated events	34.0	3542.0	102.0	-0.116	0.037	1000.0	-1000.0	-0.075	-1000.0
Nectin adhesion pathway	33.0	2124.0	63.0	-0.191	0.046	1000.0	-1000.0	-0.058	-1000.0
Endothelins	33.0	3172.0	96.0	-0.173	0.042	1000.0	-1000.0	-0.058	-1000.0
Coregulation of Androgen receptor activity	32.0	2436.0	76.0	-0.134	0.049	1000.0	-1000.0	-0.029	-1000.0
Presenilin action in Notch and Wnt signaling	32.0	1986.0	61.0	-0.132	0.069	1000.0	-1000.0	-0.045	-1000.0
S1P5 pathway	32.0	549.0	17.0	-0.041	0.033	1000.0	-1000.0	-0.021	-1000.0
IL23-mediated signaling events	32.0	1967.0	60.0	-0.395	0.026	1000.0	-1000.0	-0.152	-1000.0
LPA4-mediated signaling events	26.0	316.0	12.0	-0.057	0.007	1000.0	-1000.0	-0.024	-1000.0
Arf6 signaling events	26.0	1616.0	62.0	-0.07	0.058	1000.0	-1000.0	-0.041	-1000.0
Glucocorticoid receptor regulatory network	26.0	2984.0	114.0	-0.267	0.163	1000.0	-1000.0	-0.061	-1000.0
Integrins in angiogenesis	26.0	2234.0	84.0	-0.148	0.059	1000.0	-1000.0	-0.046	-1000.0
IGF1 pathway	26.0	1533.0	57.0	-0.022	0.051	1000.0	-1000.0	-0.041	-1000.0
S1P4 pathway	26.0	665.0	25.0	-0.041	0.041	1000.0	-1000.0	-0.031	-1000.0
Calcium signaling in the CD4+ TCR pathway	25.0	781.0	31.0	-0.12	0.027	1000.0	-1000.0	-0.048	-1000.0
Plasma membrane estrogen receptor signaling	25.0	2222.0	86.0	-0.098	0.048	1000.0	-1000.0	-0.058	-1000.0
Regulation of Androgen receptor activity	23.0	1622.0	70.0	-0.22	0.033	1000.0	-1000.0	-0.057	-1000.0
Signaling events mediated by PTP1B	22.0	1716.0	76.0	-0.132	0.045	1000.0	-1000.0	-0.043	-1000.0
Osteopontin-mediated events	21.0	827.0	38.0	-0.147	0.037	1000.0	-1000.0	-0.044	-1000.0
EGFR-dependent Endothelin signaling events	21.0	453.0	21.0	-0.031	0.039	1000.0	-1000.0	-0.041	-1000.0
Syndecan-4-mediated signaling events	21.0	1445.0	67.0	-0.174	0.036	1000.0	-1000.0	-0.044	-1000.0
PDGFR-beta signaling pathway	21.0	2058.0	97.0	-0.093	0.071	1000.0	-1000.0	-0.055	-1000.0
Aurora B signaling	21.0	1434.0	67.0	-0.3	0.078	1000.0	-1000.0	-0.036	-1000.0
ErbB4 signaling events	20.0	1422.0	69.0	-0.103	0.051	1000.0	-1000.0	-0.055	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	20.0	1071.0	52.0	-0.091	0.052	1000.0	-1000.0	-0.06	-1000.0
IL27-mediated signaling events	20.0	1047.0	51.0	-0.212	0.05	1000.0	-1000.0	-0.045	-1000.0
IL12-mediated signaling events	19.0	1723.0	87.0	-0.118	0.026	1000.0	-1000.0	-0.102	-1000.0
Sphingosine 1-phosphate (S1P) pathway	19.0	543.0	28.0	-0.035	0.04	1000.0	-1000.0	-0.023	-1000.0
Ceramide signaling pathway	19.0	1458.0	76.0	-0.031	0.07	1000.0	-1000.0	-0.041	-1000.0
Syndecan-3-mediated signaling events	19.0	693.0	35.0	-0.152	0.069	1000.0	-1000.0	-0.035	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	19.0	643.0	33.0	-0.096	0.062	1000.0	-1000.0	-0.042	-1000.0
JNK signaling in the CD4+ TCR pathway	18.0	309.0	17.0	-0.036	0.051	1000.0	-1000.0	-0.036	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	17.0	600.0	34.0	-0.018	0.042	1000.0	-1000.0	-0.03	-1000.0
PLK1 signaling events	17.0	1525.0	85.0	-0.028	0.047	1000.0	-1000.0	-0.026	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	17.0	654.0	37.0	-0.087	0.061	1000.0	-1000.0	-0.031	-1000.0
IL1-mediated signaling events	17.0	1107.0	62.0	-0.067	0.05	1000.0	-1000.0	-0.047	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	17.0	1195.0	68.0	-0.205	0.027	1000.0	-1000.0	-0.108	-1000.0
Angiopoietin receptor Tie2-mediated signaling	17.0	1498.0	88.0	-0.07	0.044	1000.0	-1000.0	-0.073	-1000.0
ErbB2/ErbB3 signaling events	16.0	1095.0	65.0	-0.082	0.038	1000.0	-1000.0	-0.068	-1000.0
Caspase cascade in apoptosis	16.0	1205.0	74.0	-0.038	0.06	1000.0	-1000.0	-0.058	-1000.0
ceramide signaling pathway	16.0	809.0	49.0	0.0	0.038	1000.0	-1000.0	-0.041	-1000.0
S1P1 pathway	16.0	592.0	36.0	-0.042	0.026	1000.0	-1000.0	-0.049	-1000.0
S1P3 pathway	16.0	702.0	42.0	-0.027	0.046	1000.0	-1000.0	-0.037	-1000.0
FAS signaling pathway (CD95)	15.0	726.0	47.0	-0.052	0.038	1000.0	-1000.0	-0.052	-1000.0
Regulation of p38-alpha and p38-beta	14.0	798.0	54.0	-0.063	0.058	1000.0	-1000.0	-0.053	-1000.0
FOXM1 transcription factor network	14.0	740.0	51.0	-0.071	0.04	1000.0	-1000.0	-0.157	-1000.0
Ras signaling in the CD4+ TCR pathway	14.0	250.0	17.0	-0.006	0.041	1000.0	-1000.0	-0.043	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	13.0	1126.0	85.0	-0.027	0.045	1000.0	-1000.0	-0.043	-1000.0
EPO signaling pathway	13.0	741.0	55.0	0.002	0.051	1000.0	-1000.0	-0.05	-1000.0
mTOR signaling pathway	13.0	707.0	53.0	-0.024	0.049	1000.0	-1000.0	-0.035	-1000.0
Class I PI3K signaling events mediated by Akt	13.0	938.0	68.0	-0.048	0.054	1000.0	-1000.0	-0.037	-1000.0
IL6-mediated signaling events	13.0	986.0	75.0	-0.214	0.041	1000.0	-1000.0	-0.085	-1000.0
IFN-gamma pathway	12.0	872.0	68.0	-0.06	0.037	1000.0	-1000.0	-0.055	-1000.0
Signaling mediated by p38-gamma and p38-delta	12.0	187.0	15.0	-0.04	0.026	1000.0	-1000.0	-0.034	-1000.0
IL2 signaling events mediated by PI3K	12.0	753.0	58.0	-0.044	0.057	1000.0	-1000.0	-0.05	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	12.0	936.0	74.0	-0.087	0.062	1000.0	-1000.0	-0.063	-1000.0
Class I PI3K signaling events	12.0	942.0	73.0	-0.063	0.045	1000.0	-1000.0	-0.054	-1000.0
PLK2 and PLK4 events	11.0	34.0	3.0	0.005	-1000.0	1000.0	-1000.0	-0.013	-1000.0
Cellular roles of Anthrax toxin	11.0	454.0	39.0	-0.018	0.03	1000.0	-1000.0	-0.025	-1000.0
Hedgehog signaling events mediated by Gli proteins	11.0	741.0	65.0	-0.125	0.06	1000.0	-1000.0	-0.05	-1000.0
Retinoic acid receptors-mediated signaling	11.0	694.0	58.0	-0.103	0.048	1000.0	-1000.0	-0.048	-1000.0
Thromboxane A2 receptor signaling	10.0	1119.0	105.0	-0.037	0.037	1000.0	-1000.0	-0.043	-1000.0
Aurora C signaling	10.0	74.0	7.0	0.0	0.033	1000.0	-1000.0	-0.012	-1000.0
PDGFR-alpha signaling pathway	10.0	478.0	44.0	-0.041	0.057	1000.0	-1000.0	-0.037	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	10.0	462.0	45.0	-0.003	0.061	1000.0	-1000.0	-0.065	-1000.0
IL2 signaling events mediated by STAT5	10.0	221.0	22.0	-0.013	0.033	1000.0	-1000.0	-0.062	-1000.0
p38 MAPK signaling pathway	10.0	479.0	44.0	-0.06	0.052	1000.0	-1000.0	-0.029	-1000.0
TCGA08_rtk_signaling	9.0	257.0	26.0	-0.047	0.083	1000.0	-1000.0	-0.02	-1000.0
E-cadherin signaling in the nascent adherens junction	9.0	706.0	76.0	-0.011	0.056	1000.0	-1000.0	-0.06	-1000.0
Signaling events mediated by PRL	9.0	311.0	34.0	-0.051	0.038	1000.0	-1000.0	-0.044	-1000.0
E-cadherin signaling in keratinocytes	9.0	388.0	43.0	-0.034	0.043	1000.0	-1000.0	-0.039	-1000.0
Aurora A signaling	8.0	533.0	60.0	-0.066	0.056	1000.0	-1000.0	-0.025	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	8.0	689.0	83.0	-0.095	0.051	1000.0	-1000.0	-0.045	-1000.0
Signaling mediated by p38-alpha and p38-beta	8.0	357.0	44.0	-0.088	0.027	1000.0	-1000.0	-0.037	-1000.0
Regulation of Telomerase	8.0	838.0	102.0	-0.065	0.061	1000.0	-1000.0	-0.062	-1000.0
E-cadherin signaling events	8.0	42.0	5.0	0.019	0.038	1000.0	-1000.0	0.004	-1000.0
Regulation of nuclear SMAD2/3 signaling	7.0	1026.0	136.0	-0.112	0.073	1000.0	-1000.0	-0.055	-1000.0
FoxO family signaling	7.0	457.0	64.0	-0.009	0.068	1000.0	-1000.0	-0.066	-1000.0
Rapid glucocorticoid signaling	7.0	141.0	20.0	-0.009	0.033	1000.0	-1000.0	-0.011	-1000.0
Insulin-mediated glucose transport	6.0	215.0	32.0	-0.067	0.05	1000.0	-1000.0	-0.033	-1000.0
HIF-2-alpha transcription factor network	6.0	276.0	43.0	-0.048	0.052	1000.0	-1000.0	-0.075	-1000.0
Arf6 trafficking events	6.0	491.0	71.0	-0.096	0.048	1000.0	-1000.0	-0.034	-1000.0
Insulin Pathway	6.0	474.0	74.0	-0.026	0.072	1000.0	-1000.0	-0.049	-1000.0
Canonical NF-kappaB pathway	5.0	230.0	39.0	0.0	0.056	1000.0	-1000.0	-0.042	-1000.0
Signaling events mediated by HDAC Class III	5.0	232.0	40.0	-0.048	0.049	1000.0	-1000.0	-0.019	-1000.0
a4b1 and a4b7 Integrin signaling	4.0	23.0	5.0	0.023	0.035	1000.0	-1000.0	0.006	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	4.0	594.0	125.0	-0.0	0.067	1000.0	-1000.0	-0.052	-1000.0
VEGFR1 specific signals	4.0	238.0	56.0	-0.017	0.055	1000.0	-1000.0	-0.053	-1000.0
Class IB PI3K non-lipid kinase events	4.0	12.0	3.0	-0.024	0.024	1000.0	-1000.0	-0.009	-1000.0
Arf6 downstream pathway	3.0	171.0	43.0	-0.036	0.045	1000.0	-1000.0	-0.038	-1000.0
Signaling events mediated by HDAC Class I	3.0	342.0	104.0	-0.05	0.064	1000.0	-1000.0	-0.039	-1000.0
BARD1 signaling events	2.0	151.0	57.0	-0.054	0.066	1000.0	-1000.0	-0.044	-1000.0
TRAIL signaling pathway	2.0	98.0	48.0	-0.0	0.052	1000.0	-1000.0	-0.043	-1000.0
Paxillin-dependent events mediated by a4b1	2.0	77.0	36.0	-0.049	0.051	1000.0	-1000.0	-0.04	-1000.0
Atypical NF-kappaB pathway	2.0	89.0	31.0	-0.004	0.032	1000.0	-1000.0	-0.03	-1000.0
Arf1 pathway	2.0	128.0	54.0	-0.001	0.042	1000.0	-1000.0	-0.024	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	1.0	32.0	23.0	0.01	0.044	1000.0	-1000.0	-0.036	-1000.0
Signaling events mediated by HDAC Class II	1.0	143.0	75.0	-0.027	0.068	1000.0	-1000.0	-0.032	-1000.0
Circadian rhythm pathway	1.0	31.0	22.0	-0.008	0.06	1000.0	-1000.0	-0.039	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	7.0	27.0	-0.0	0.057	1000.0	-1000.0	-0.034	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.07	1000.0	-1000.0	0.0	-1000.0
Total	3218	188101	7203	-11.8614216893	-993.275192752	131000	-131000	-6.12456200561	-131000