Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.227 0.407 -9999.0 0.0 -0.893 36.0 36.0 IHH -0.124 0.304 -9999.0 0.0 -0.726 28.0 28.0 SHH Np/Cholesterol/GAS1 -0.053 0.165 -9999.0 0.0 -0.395 28.0 28.0 LRPAP1 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.053 0.164 0.393 28.0 -9999.0 0.0 28.0 SMO/beta Arrestin2 -0.141 0.237 -9999.0 0.0 -0.496 35.0 35.0 SMO -0.145 0.246 -9999.0 0.0 -0.482 46.0 46.0 AKT1 -0.051 0.138 -9999.0 0.0 -0.69 3.0 3.0 ARRB2 0.025 0.005 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.001 0.162 -9999.0 0.0 -0.67 8.0 8.0 ADRBK1 0.023 0.007 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.144 0.242 -9999.0 0.0 -0.474 46.0 46.0 STIL -0.16 0.23 0.327 1.0 -0.396 62.0 63.0 DHH N/PTCH2 0.014 0.133 -9999.0 0.0 -0.564 7.0 7.0 DHH N/PTCH1 -0.129 0.248 -9999.0 0.0 -0.431 55.0 55.0 PIK3CA 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.004 0.14 -9999.0 0.0 -0.67 6.0 6.0 PTHLH -0.247 0.386 -9999.0 0.0 -0.871 35.0 35.0 determination of left/right symmetry -0.144 0.242 -9999.0 0.0 -0.474 46.0 46.0 PIK3R1 0.02 0.057 -9999.0 0.0 -0.67 1.0 1.0 skeletal system development -0.244 0.381 -9999.0 0.0 -0.859 35.0 35.0 IHH N/Hhip -0.163 0.325 -9999.0 0.0 -0.614 47.0 47.0 DHH N/Hhip -0.082 0.25 -9999.0 0.0 -0.523 35.0 35.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.144 0.242 -9999.0 0.0 -0.474 46.0 46.0 pancreas development -0.106 0.285 -9999.0 0.0 -0.659 31.0 31.0 HHAT 0.025 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.032 0.045 -9999.0 0.0 -0.506 1.0 1.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.018 0.082 -9999.0 0.0 -0.67 2.0 2.0 somite specification -0.144 0.242 -9999.0 0.0 -0.474 46.0 46.0 SHH Np/Cholesterol/PTCH1 -0.169 0.239 -9999.0 0.0 -0.407 66.0 66.0 SHH Np/Cholesterol/PTCH2 -0.057 0.166 -9999.0 0.0 -0.402 28.0 28.0 SHH Np/Cholesterol/Megalin -0.122 0.244 0.191 2.0 -0.445 51.0 53.0 SHH -0.08 0.196 -9999.0 0.0 -0.507 26.0 26.0 catabolic process -0.14 0.243 -9999.0 0.0 -0.444 55.0 55.0 SMO/Vitamin D3 -0.165 0.261 0.473 1.0 -0.433 63.0 64.0 SHH Np/Cholesterol/Hhip -0.126 0.246 -9999.0 0.0 -0.465 47.0 47.0 LRP2 -0.099 0.294 -9999.0 0.0 -0.67 31.0 31.0 receptor-mediated endocytosis -0.224 0.282 -9999.0 0.0 -0.509 60.0 60.0 SHH Np/Cholesterol/BOC -0.063 0.192 -9999.0 0.0 -0.42 32.0 32.0 SHH Np/Cholesterol/CDO -0.056 0.157 -9999.0 0.0 -0.396 26.0 26.0 mesenchymal cell differentiation 0.125 0.244 0.461 47.0 -9999.0 0.0 47.0 mol:Vitamin D3 -0.161 0.252 0.434 1.0 -0.415 63.0 64.0 IHH N/PTCH2 -0.072 0.212 -9999.0 0.0 -0.479 30.0 30.0 CDON 0.016 0.031 -9999.0 0.0 -0.342 1.0 1.0 IHH N/PTCH1 -0.127 0.258 -9999.0 0.0 -0.448 55.0 55.0 Megalin/LRPAP1 -0.062 0.228 -9999.0 0.0 -0.506 31.0 31.0 PTCH2 0.016 0.08 -9999.0 0.0 -0.67 2.0 2.0 SHH Np/Cholesterol -0.059 0.157 -9999.0 0.0 -0.401 26.0 26.0 PTCH1 -0.141 0.243 -9999.0 0.0 -0.445 55.0 55.0 HHIP -0.106 0.285 -9999.0 0.0 -0.66 31.0 31.0