Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Signaling events mediated by the Hedgehog family	29.0	1544.0	52.0	-0.247	0.125	1000.0	-1000.0	-0.031	-1000.0
FOXA2 and FOXA3 transcription factor networks	25.0	1173.0	46.0	-0.684	0.029	1000.0	-1000.0	-0.072	-1000.0
IL4-mediated signaling events	22.0	2071.0	91.0	-0.605	0.537	1000.0	-1000.0	-0.119	-1000.0
IL23-mediated signaling events	21.0	1310.0	60.0	-0.436	0.026	1000.0	-1000.0	-0.062	-1000.0
Syndecan-1-mediated signaling events	17.0	599.0	34.0	-0.182	0.026	1000.0	-1000.0	-0.048	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	17.0	1340.0	78.0	-0.155	0.104	1000.0	-1000.0	-0.054	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	15.0	531.0	34.0	-0.062	0.026	1000.0	-1000.0	-0.039	-1000.0
Osteopontin-mediated events	15.0	586.0	38.0	-0.132	0.035	1000.0	-1000.0	-0.056	-1000.0
Syndecan-4-mediated signaling events	15.0	1054.0	67.0	-0.179	0.035	1000.0	-1000.0	-0.05	-1000.0
E-cadherin signaling events	15.0	75.0	5.0	-0.091	0.026	1000.0	-1000.0	0.008	-1000.0
Glucocorticoid receptor regulatory network	14.0	1694.0	114.0	-0.515	0.2	1000.0	-1000.0	-0.051	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	14.0	1074.0	74.0	-0.097	0.048	1000.0	-1000.0	-0.068	-1000.0
IL12-mediated signaling events	13.0	1182.0	87.0	-0.316	0.083	1000.0	-1000.0	-0.097	-1000.0
Ephrin A  reverse signaling	13.0	91.0	7.0	-0.05	0.012	1000.0	-1000.0	-0.012	-1000.0
p75(NTR)-mediated signaling	13.0	1697.0	125.0	-0.193	0.05	1000.0	-1000.0	-0.07	-1000.0
Reelin signaling pathway	13.0	743.0	56.0	-0.113	0.054	1000.0	-1000.0	-0.032	-1000.0
Calcium signaling in the CD4+ TCR pathway	13.0	420.0	31.0	-0.251	0.025	1000.0	-1000.0	-0.055	-1000.0
Caspase cascade in apoptosis	12.0	890.0	74.0	-0.193	0.06	1000.0	-1000.0	-0.042	-1000.0
Glypican 1 network	12.0	593.0	48.0	-0.152	0.049	1000.0	-1000.0	-0.039	-1000.0
Signaling events regulated by Ret tyrosine kinase	12.0	990.0	82.0	-0.07	0.027	1000.0	-1000.0	-0.063	-1000.0
Endothelins	12.0	1225.0	96.0	-0.177	0.056	1000.0	-1000.0	-0.043	-1000.0
Integrins in angiogenesis	12.0	1020.0	84.0	-0.188	0.043	1000.0	-1000.0	-0.058	-1000.0
TCR signaling in naïve CD8+ T cells	12.0	1167.0	93.0	-0.18	0.036	1000.0	-1000.0	-0.046	-1000.0
IL27-mediated signaling events	12.0	622.0	51.0	-0.203	0.122	1000.0	-1000.0	-0.066	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	12.0	870.0	68.0	-0.348	0.048	1000.0	-1000.0	-0.095	-1000.0
amb2 Integrin signaling	11.0	931.0	82.0	-0.206	0.037	1000.0	-1000.0	-0.038	-1000.0
LPA receptor mediated events	11.0	1174.0	102.0	-0.142	0.026	1000.0	-1000.0	-0.055	-1000.0
E-cadherin signaling in the nascent adherens junction	11.0	855.0	76.0	-0.096	0.045	1000.0	-1000.0	-0.056	-1000.0
IFN-gamma pathway	10.0	737.0	68.0	-0.116	0.034	1000.0	-1000.0	-0.05	-1000.0
Signaling mediated by p38-alpha and p38-beta	10.0	477.0	44.0	-0.158	0.026	1000.0	-1000.0	-0.027	-1000.0
IL6-mediated signaling events	10.0	776.0	75.0	-0.198	0.034	1000.0	-1000.0	-0.049	-1000.0
BMP receptor signaling	9.0	799.0	81.0	-0.122	0.046	1000.0	-1000.0	-0.059	-1000.0
IGF1 pathway	9.0	567.0	57.0	-0.064	0.048	1000.0	-1000.0	-0.045	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	9.0	1096.0	120.0	-0.223	0.194	1000.0	-1000.0	-0.048	-1000.0
E-cadherin signaling in keratinocytes	9.0	425.0	43.0	-0.091	0.027	1000.0	-1000.0	-0.032	-1000.0
HIF-1-alpha transcription factor network	8.0	671.0	76.0	-0.101	0.066	1000.0	-1000.0	-0.067	-1000.0
FAS signaling pathway (CD95)	8.0	399.0	47.0	-0.15	0.146	1000.0	-1000.0	-0.036	-1000.0
JNK signaling in the CD4+ TCR pathway	7.0	132.0	17.0	-0.074	0.025	1000.0	-1000.0	-0.027	-1000.0
Noncanonical Wnt signaling pathway	7.0	183.0	26.0	-0.062	0.036	1000.0	-1000.0	-0.044	-1000.0
Arf6 signaling events	7.0	467.0	62.0	-0.151	0.028	1000.0	-1000.0	-0.041	-1000.0
Nectin adhesion pathway	7.0	458.0	63.0	-0.091	0.052	1000.0	-1000.0	-0.056	-1000.0
Ephrin B reverse signaling	7.0	351.0	48.0	-0.04	0.027	1000.0	-1000.0	-0.022	-1000.0
Wnt signaling	7.0	53.0	7.0	-0.037	0.036	1000.0	-1000.0	-0.018	-1000.0
BCR signaling pathway	7.0	790.0	99.0	-0.093	0.047	1000.0	-1000.0	-0.062	-1000.0
LPA4-mediated signaling events	6.0	74.0	12.0	-0.077	0.004	1000.0	-1000.0	-0.018	-1000.0
Coregulation of Androgen receptor activity	6.0	486.0	76.0	-0.415	0.039	1000.0	-1000.0	-0.028	-1000.0
BARD1 signaling events	6.0	346.0	57.0	-0.046	0.04	1000.0	-1000.0	-0.057	-1000.0
Signaling events mediated by PTP1B	6.0	524.0	76.0	-0.092	0.07	1000.0	-1000.0	-0.044	-1000.0
EPO signaling pathway	6.0	349.0	55.0	-0.017	0.122	1000.0	-1000.0	-0.054	-1000.0
Ceramide signaling pathway	6.0	457.0	76.0	-0.059	0.065	1000.0	-1000.0	-0.039	-1000.0
IL2 signaling events mediated by PI3K	6.0	376.0	58.0	-0.073	0.041	1000.0	-1000.0	-0.034	-1000.0
Nongenotropic Androgen signaling	6.0	354.0	52.0	-0.082	0.039	1000.0	-1000.0	-0.032	-1000.0
ErbB2/ErbB3 signaling events	5.0	336.0	65.0	-0.045	0.115	1000.0	-1000.0	-0.058	-1000.0
ErbB4 signaling events	5.0	353.0	69.0	-0.208	0.078	1000.0	-1000.0	-0.042	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	5.0	316.0	54.0	-0.119	0.037	1000.0	-1000.0	-0.051	-1000.0
Thromboxane A2 receptor signaling	5.0	540.0	105.0	-0.03	0.033	1000.0	-1000.0	-0.046	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	5.0	455.0	85.0	-0.096	0.034	1000.0	-1000.0	-0.046	-1000.0
Syndecan-3-mediated signaling events	5.0	201.0	35.0	-0.078	0.047	1000.0	-1000.0	-0.033	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	5.0	268.0	45.0	-0.084	0.037	1000.0	-1000.0	-0.046	-1000.0
EPHB forward signaling	5.0	442.0	85.0	-0.05	0.058	1000.0	-1000.0	-0.068	-1000.0
Regulation of Androgen receptor activity	5.0	350.0	70.0	-0.478	0.03	1000.0	-1000.0	-0.063	-1000.0
Ras signaling in the CD4+ TCR pathway	5.0	94.0	17.0	-0.011	0.028	1000.0	-1000.0	-0.023	-1000.0
Syndecan-2-mediated signaling events	4.0	307.0	69.0	-0.078	0.042	1000.0	-1000.0	-0.027	-1000.0
a4b1 and a4b7 Integrin signaling	4.0	23.0	5.0	-0.011	0.025	1000.0	-1000.0	0.003	-1000.0
Presenilin action in Notch and Wnt signaling	4.0	279.0	61.0	-0.111	0.047	1000.0	-1000.0	-0.049	-1000.0
Fc-epsilon receptor I signaling in mast cells	4.0	469.0	97.0	-0.068	0.116	1000.0	-1000.0	-0.056	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	4.0	148.0	37.0	-0.046	0.052	1000.0	-1000.0	-0.033	-1000.0
IL1-mediated signaling events	4.0	271.0	62.0	-0.048	0.056	1000.0	-1000.0	-0.043	-1000.0
ceramide signaling pathway	4.0	224.0	49.0	-0.029	0.035	1000.0	-1000.0	-0.039	-1000.0
HIF-2-alpha transcription factor network	4.0	194.0	43.0	-0.11	0.037	1000.0	-1000.0	-0.075	-1000.0
Retinoic acid receptors-mediated signaling	4.0	232.0	58.0	-0.041	0.05	1000.0	-1000.0	-0.052	-1000.0
Canonical Wnt signaling pathway	4.0	246.0	51.0	-0.095	0.138	1000.0	-1000.0	-0.064	-1000.0
Effects of Botulinum toxin	4.0	121.0	26.0	-0.039	0.031	1000.0	-1000.0	-0.003	-1000.0
IL2 signaling events mediated by STAT5	4.0	99.0	22.0	-0.049	0.097	1000.0	-1000.0	-0.038	-1000.0
EGFR-dependent Endothelin signaling events	4.0	103.0	21.0	-0.03	0.036	1000.0	-1000.0	-0.042	-1000.0
Visual signal transduction: Rods	4.0	229.0	52.0	-0.042	0.054	1000.0	-1000.0	-0.037	-1000.0
Regulation of nuclear SMAD2/3 signaling	3.0	485.0	136.0	-0.098	0.065	1000.0	-1000.0	-0.043	-1000.0
PDGFR-alpha signaling pathway	3.0	164.0	44.0	-0.132	0.046	1000.0	-1000.0	-0.046	-1000.0
TRAIL signaling pathway	3.0	163.0	48.0	-0.005	0.039	1000.0	-1000.0	-0.048	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	3.0	173.0	52.0	-0.053	0.072	1000.0	-1000.0	-0.037	-1000.0
Regulation of p38-alpha and p38-beta	3.0	166.0	54.0	-0.05	0.056	1000.0	-1000.0	-0.056	-1000.0
Class I PI3K signaling events	3.0	246.0	73.0	-0.041	0.119	1000.0	-1000.0	-0.045	-1000.0
TCGA08_retinoblastoma	3.0	31.0	8.0	-0.011	0.016	1000.0	-1000.0	-0.001	-1000.0
Regulation of Telomerase	3.0	397.0	102.0	-0.154	0.049	1000.0	-1000.0	-0.054	-1000.0
Insulin Pathway	3.0	244.0	74.0	-0.029	0.064	1000.0	-1000.0	-0.052	-1000.0
Angiopoietin receptor Tie2-mediated signaling	3.0	284.0	88.0	-0.051	0.043	1000.0	-1000.0	-0.063	-1000.0
FOXM1 transcription factor network	3.0	203.0	51.0	-0.022	0.08	1000.0	-1000.0	-0.091	-1000.0
PLK2 and PLK4 events	2.0	6.0	3.0	0.004	0.025	1000.0	-1000.0	-0.009	-1000.0
Visual signal transduction: Cones	2.0	110.0	38.0	-0.033	0.058	1000.0	-1000.0	-0.017	-1000.0
Cellular roles of Anthrax toxin	2.0	89.0	39.0	-0.031	0.031	1000.0	-1000.0	-0.022	-1000.0
Aurora A signaling	2.0	160.0	60.0	-0.125	0.05	1000.0	-1000.0	-0.018	-1000.0
PLK1 signaling events	2.0	248.0	85.0	-0.034	0.037	1000.0	-1000.0	-0.035	-1000.0
mTOR signaling pathway	2.0	124.0	53.0	-0.021	0.028	1000.0	-1000.0	-0.037	-1000.0
Signaling events mediated by HDAC Class III	2.0	90.0	40.0	-0.051	0.052	1000.0	-1000.0	-0.025	-1000.0
FoxO family signaling	2.0	183.0	64.0	-0.15	0.141	1000.0	-1000.0	-0.059	-1000.0
Paxillin-dependent events mediated by a4b1	2.0	74.0	36.0	-0.043	0.045	1000.0	-1000.0	-0.037	-1000.0
Atypical NF-kappaB pathway	2.0	73.0	31.0	-0.017	0.032	1000.0	-1000.0	-0.019	-1000.0
Plasma membrane estrogen receptor signaling	2.0	234.0	86.0	-0.108	0.122	1000.0	-1000.0	-0.063	-1000.0
Rapid glucocorticoid signaling	2.0	44.0	20.0	-0.019	0.033	1000.0	-1000.0	-0.008	-1000.0
Signaling events mediated by PRL	2.0	91.0	34.0	-0.095	0.037	1000.0	-1000.0	-0.044	-1000.0
Class IB PI3K non-lipid kinase events	2.0	6.0	3.0	-0.018	0.018	1000.0	-1000.0	-0.002	-1000.0
S1P4 pathway	2.0	72.0	25.0	-0.005	0.033	1000.0	-1000.0	-0.024	-1000.0
p38 MAPK signaling pathway	2.0	111.0	44.0	-0.048	0.042	1000.0	-1000.0	-0.028	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	1.0	29.0	23.0	-0.025	0.056	1000.0	-1000.0	-0.031	-1000.0
Canonical NF-kappaB pathway	1.0	39.0	39.0	-0.019	0.088	1000.0	-1000.0	-0.033	-1000.0
Sphingosine 1-phosphate (S1P) pathway	1.0	50.0	28.0	-0.01	0.044	1000.0	-1000.0	-0.021	-1000.0
Hedgehog signaling events mediated by Gli proteins	1.0	125.0	65.0	-0.168	0.061	1000.0	-1000.0	-0.041	-1000.0
Aurora C signaling	1.0	10.0	7.0	-0.0	0.03	1000.0	-1000.0	-0.014	-1000.0
Class I PI3K signaling events mediated by Akt	1.0	80.0	68.0	-0.036	0.156	1000.0	-1000.0	-0.034	-1000.0
S1P5 pathway	1.0	23.0	17.0	-0.023	0.028	1000.0	-1000.0	-0.014	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	123.0	83.0	-0.022	0.048	1000.0	-1000.0	-0.038	-1000.0
S1P1 pathway	1.0	64.0	36.0	-0.001	0.028	1000.0	-1000.0	-0.037	-1000.0
TCGA08_p53	1.0	8.0	7.0	-0.007	0.025	1000.0	-1000.0	-0.01	-1000.0
Signaling mediated by p38-gamma and p38-delta	1.0	23.0	15.0	-0.029	0.026	1000.0	-1000.0	-0.032	-1000.0
Glypican 2 network	1.0	6.0	4.0	0.019	0.027	1000.0	-1000.0	0.006	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	1.0	225.0	125.0	-0.063	0.081	1000.0	-1000.0	-0.072	-1000.0
TCGA08_rtk_signaling	1.0	51.0	26.0	-0.015	0.07	1000.0	-1000.0	-0.006	-1000.0
Arf6 trafficking events	1.0	92.0	71.0	-0.042	0.048	1000.0	-1000.0	-0.027	-1000.0
S1P3 pathway	1.0	51.0	42.0	-0.003	0.043	1000.0	-1000.0	-0.042	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	1.0	58.0	33.0	-0.0	0.056	1000.0	-1000.0	-0.033	-1000.0
PDGFR-beta signaling pathway	1.0	187.0	97.0	-0.063	0.071	1000.0	-1000.0	-0.053	-1000.0
Aurora B signaling	1.0	102.0	67.0	-0.049	0.06	1000.0	-1000.0	-0.054	-1000.0
Signaling events mediated by HDAC Class II	0.0	42.0	75.0	-0.034	0.073	1000.0	-1000.0	-0.028	-1000.0
Circadian rhythm pathway	0.0	4.0	22.0	-0.009	0.051	1000.0	-1000.0	-0.029	-1000.0
Arf6 downstream pathway	0.0	36.0	43.0	-0.043	0.047	1000.0	-1000.0	-0.034	-1000.0
Insulin-mediated glucose transport	0.0	19.0	32.0	-0.018	0.051	1000.0	-1000.0	-0.036	-1000.0
Signaling events mediated by HDAC Class I	0.0	98.0	104.0	-0.049	0.088	1000.0	-1000.0	-0.037	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	0.0	27.0	-0.0	0.06	1000.0	-1000.0	-0.037	-1000.0
VEGFR1 specific signals	0.0	28.0	56.0	-0.006	0.062	1000.0	-1000.0	-0.058	-1000.0
Arf1 pathway	0.0	6.0	54.0	-0.001	0.035	1000.0	-1000.0	-0.024	-1000.0
Alternative NF-kappaB pathway	0.0	5.0	13.0	-0.0	0.068	1000.0	-1000.0	-0.0	-1000.0
Total	782	51023	7203	-13.0438746509	7.60812577251	131000	-131000	-5.38749258422	-131000