This pipeline computes the correlation between cancer subtypes identified by different molecular patterns and selected clinical features.
Testing the association between subtypes identified by 10 different clustering approaches and 17 clinical features across 503 patients, 78 significant findings detected with P value < 0.05 and Q value < 0.25.
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3 subtypes identified in current cancer cohort by 'Copy Number Ratio CNMF subtypes'. These subtypes correlate to 'RACE'.
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5 subtypes identified in current cancer cohort by 'METHLYATION CNMF'. These subtypes correlate to 'YEARS_TO_BIRTH', 'PATHOLOGIC_STAGE', 'PATHOLOGY_T_STAGE', 'PATHOLOGY_N_STAGE', 'HISTOLOGICAL_TYPE', 'EXTRATHYROIDAL_EXTENSION', and 'NUMBER_OF_LYMPH_NODES'.
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CNMF clustering analysis on RPPA data identified 4 subtypes that correlate to 'YEARS_TO_BIRTH', 'PATHOLOGIC_STAGE', 'PATHOLOGY_T_STAGE', 'PATHOLOGY_N_STAGE', 'HISTOLOGICAL_TYPE', and 'EXTRATHYROIDAL_EXTENSION'.
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Consensus hierarchical clustering analysis on RPPA data identified 7 subtypes that correlate to 'Time to Death', 'YEARS_TO_BIRTH', 'PATHOLOGIC_STAGE', 'PATHOLOGY_T_STAGE', 'PATHOLOGY_N_STAGE', 'HISTOLOGICAL_TYPE', 'EXTRATHYROIDAL_EXTENSION', and 'TUMOR_SIZE'.
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CNMF clustering analysis on sequencing-based mRNA expression data identified 4 subtypes that correlate to 'YEARS_TO_BIRTH', 'PATHOLOGIC_STAGE', 'PATHOLOGY_T_STAGE', 'PATHOLOGY_N_STAGE', 'HISTOLOGICAL_TYPE', 'EXTRATHYROIDAL_EXTENSION', 'NUMBER_OF_LYMPH_NODES', and 'ETHNICITY'.
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Consensus hierarchical clustering analysis on sequencing-based mRNA expression data identified 5 subtypes that correlate to 'YEARS_TO_BIRTH', 'PATHOLOGIC_STAGE', 'PATHOLOGY_T_STAGE', 'PATHOLOGY_N_STAGE', 'HISTOLOGICAL_TYPE', 'EXTRATHYROIDAL_EXTENSION', 'RESIDUAL_TUMOR', 'NUMBER_OF_LYMPH_NODES', 'TUMOR_SIZE', 'RACE', and 'ETHNICITY'.
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4 subtypes identified in current cancer cohort by 'MIRSEQ CNMF'. These subtypes correlate to 'PATHOLOGIC_STAGE', 'PATHOLOGY_T_STAGE', 'PATHOLOGY_N_STAGE', 'HISTOLOGICAL_TYPE', 'EXTRATHYROIDAL_EXTENSION', 'NUMBER_OF_LYMPH_NODES', 'MULTIFOCALITY', 'TUMOR_SIZE', and 'RACE'.
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3 subtypes identified in current cancer cohort by 'MIRSEQ CHIERARCHICAL'. These subtypes correlate to 'Time to Death', 'YEARS_TO_BIRTH', 'PATHOLOGIC_STAGE', 'PATHOLOGY_T_STAGE', 'PATHOLOGY_N_STAGE', 'HISTOLOGICAL_TYPE', 'EXTRATHYROIDAL_EXTENSION', 'NUMBER_OF_LYMPH_NODES', and 'TUMOR_SIZE'.
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4 subtypes identified in current cancer cohort by 'MIRseq Mature CNMF subtypes'. These subtypes correlate to 'Time to Death', 'YEARS_TO_BIRTH', 'PATHOLOGIC_STAGE', 'PATHOLOGY_T_STAGE', 'PATHOLOGY_N_STAGE', 'HISTOLOGICAL_TYPE', 'RADIATION_EXPOSURE', 'EXTRATHYROIDAL_EXTENSION', 'NUMBER_OF_LYMPH_NODES', and 'RACE'.
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3 subtypes identified in current cancer cohort by 'MIRseq Mature cHierClus subtypes'. These subtypes correlate to 'Time to Death', 'YEARS_TO_BIRTH', 'PATHOLOGIC_STAGE', 'PATHOLOGY_T_STAGE', 'PATHOLOGY_N_STAGE', 'HISTOLOGICAL_TYPE', 'EXTRATHYROIDAL_EXTENSION', 'NUMBER_OF_LYMPH_NODES', and 'TUMOR_SIZE'.
Clinical Features |
Statistical Tests |
Copy Number Ratio CNMF subtypes |
METHLYATION CNMF |
RPPA CNMF subtypes |
RPPA cHierClus subtypes |
RNAseq CNMF subtypes |
RNAseq cHierClus subtypes |
MIRSEQ CNMF |
MIRSEQ CHIERARCHICAL |
MIRseq Mature CNMF subtypes |
MIRseq Mature cHierClus subtypes |
Time to Death | logrank test |
0.776 (0.849) |
0.218 (0.357) |
0.272 (0.428) |
0.000176 (0.000635) |
0.181 (0.311) |
0.411 (0.537) |
0.152 (0.277) |
0.00998 (0.0261) |
0.00375 (0.0105) |
0.00358 (0.0102) |
YEARS TO BIRTH | Kruskal-Wallis (anova) |
0.207 (0.341) |
0.0375 (0.0846) |
0.00137 (0.0042) |
0.000996 (0.00321) |
0.0419 (0.0924) |
0.00239 (0.007) |
0.111 (0.215) |
0.00138 (0.0042) |
0.000587 (0.002) |
0.000305 (0.00108) |
PATHOLOGIC STAGE | Fisher's exact test |
0.357 (0.495) |
4e-05 (0.000158) |
0.00036 (0.00125) |
0.00112 (0.00353) |
2e-05 (8.5e-05) |
1e-05 (4.72e-05) |
1e-05 (4.72e-05) |
1e-05 (4.72e-05) |
2e-05 (8.5e-05) |
1e-05 (4.72e-05) |
PATHOLOGY T STAGE | Fisher's exact test |
0.301 (0.454) |
4e-05 (0.000158) |
0.0121 (0.0311) |
0.00013 (0.00048) |
1e-05 (4.72e-05) |
1e-05 (4.72e-05) |
6e-05 (0.000227) |
2e-05 (8.5e-05) |
0.00076 (0.00253) |
6e-05 (0.000227) |
PATHOLOGY N STAGE | Fisher's exact test |
0.544 (0.685) |
1e-05 (4.72e-05) |
1e-05 (4.72e-05) |
0.00833 (0.0225) |
1e-05 (4.72e-05) |
1e-05 (4.72e-05) |
1e-05 (4.72e-05) |
1e-05 (4.72e-05) |
1e-05 (4.72e-05) |
1e-05 (4.72e-05) |
PATHOLOGY M STAGE | Fisher's exact test |
0.519 (0.663) |
0.779 (0.849) |
0.669 (0.79) |
0.756 (0.841) |
0.754 (0.841) |
0.402 (0.534) |
0.663 (0.79) |
0.334 (0.477) |
0.406 (0.535) |
0.333 (0.477) |
GENDER | Fisher's exact test |
0.974 (0.986) |
0.892 (0.937) |
0.434 (0.559) |
0.942 (0.965) |
0.717 (0.824) |
0.174 (0.305) |
0.986 (0.992) |
0.638 (0.774) |
0.701 (0.817) |
0.328 (0.477) |
RADIATION THERAPY | Fisher's exact test |
0.376 (0.515) |
0.0845 (0.171) |
0.131 (0.248) |
0.786 (0.851) |
0.352 (0.494) |
0.157 (0.283) |
0.808 (0.864) |
0.744 (0.841) |
0.906 (0.939) |
0.747 (0.841) |
HISTOLOGICAL TYPE | Fisher's exact test |
0.387 (0.526) |
1e-05 (4.72e-05) |
1e-05 (4.72e-05) |
1e-05 (4.72e-05) |
1e-05 (4.72e-05) |
1e-05 (4.72e-05) |
1e-05 (4.72e-05) |
1e-05 (4.72e-05) |
1e-05 (4.72e-05) |
1e-05 (4.72e-05) |
RADIATION EXPOSURE | Fisher's exact test |
0.664 (0.79) |
0.358 (0.495) |
0.974 (0.986) |
0.235 (0.38) |
1 (1.00) |
0.252 (0.401) |
0.858 (0.906) |
0.905 (0.939) |
0.0293 (0.0691) |
0.729 (0.831) |
EXTRATHYROIDAL EXTENSION | Fisher's exact test |
0.328 (0.477) |
1e-05 (4.72e-05) |
0.00571 (0.0157) |
1e-05 (4.72e-05) |
1e-05 (4.72e-05) |
1e-05 (4.72e-05) |
2e-05 (8.5e-05) |
1e-05 (4.72e-05) |
3e-05 (0.000124) |
1e-05 (4.72e-05) |
RESIDUAL TUMOR | Fisher's exact test |
0.0836 (0.171) |
0.0872 (0.174) |
0.134 (0.248) |
0.0952 (0.188) |
0.0618 (0.133) |
0.0194 (0.0491) |
0.306 (0.454) |
0.192 (0.326) |
0.426 (0.553) |
0.202 (0.337) |
NUMBER OF LYMPH NODES | Kruskal-Wallis (anova) |
0.16 (0.283) |
3.83e-08 (1.63e-06) |
0.0625 (0.133) |
0.4 (0.534) |
7.41e-08 (2.52e-06) |
8.8e-09 (4.99e-07) |
3.59e-09 (3.62e-07) |
4.26e-09 (3.62e-07) |
2.8e-07 (6.81e-06) |
9.07e-08 (2.57e-06) |
MULTIFOCALITY | Fisher's exact test |
0.0671 (0.141) |
0.286 (0.446) |
0.159 (0.283) |
0.18 (0.311) |
0.121 (0.231) |
0.242 (0.387) |
0.0205 (0.0505) |
0.608 (0.746) |
0.348 (0.494) |
0.648 (0.781) |
TUMOR SIZE | Kruskal-Wallis (anova) |
0.606 (0.746) |
0.685 (0.804) |
0.768 (0.848) |
0.0203 (0.0505) |
0.0784 (0.163) |
0.00195 (0.00583) |
0.0298 (0.0693) |
0.0378 (0.0846) |
0.109 (0.212) |
0.0221 (0.0537) |
RACE | Fisher's exact test |
0.00984 (0.0261) |
0.821 (0.872) |
0.305 (0.454) |
0.297 (0.454) |
0.578 (0.723) |
0.001 (0.00321) |
0.0278 (0.0667) |
0.2 (0.337) |
0.0445 (0.0969) |
0.134 (0.248) |
ETHNICITY | Fisher's exact test |
0.305 (0.454) |
0.39 (0.526) |
0.61 (0.746) |
0.937 (0.965) |
0.00355 (0.0102) |
0.0307 (0.0706) |
0.307 (0.454) |
0.798 (0.859) |
0.715 (0.824) |
0.523 (0.664) |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 132 | 138 | 229 |
P value = 0.776 (logrank test), Q value = 0.85
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 498 | 16 | 0.2 - 178.3 (31.2) |
subtype1 | 132 | 5 | 0.9 - 158.8 (31.5) |
subtype2 | 138 | 5 | 2.6 - 178.3 (31.5) |
subtype3 | 228 | 6 | 0.2 - 169.3 (31.0) |
P value = 0.207 (Kruskal-Wallis (anova)), Q value = 0.34
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 499 | 47.3 (15.8) |
subtype1 | 132 | 49.3 (16.1) |
subtype2 | 138 | 46.5 (16.7) |
subtype3 | 229 | 46.5 (14.9) |
P value = 0.357 (Fisher's exact test), Q value = 0.5
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV | STAGE IVA | STAGE IVC |
---|---|---|---|---|---|---|
ALL | 282 | 50 | 111 | 2 | 46 | 6 |
subtype1 | 71 | 9 | 29 | 2 | 17 | 2 |
subtype2 | 80 | 17 | 27 | 0 | 13 | 1 |
subtype3 | 131 | 24 | 55 | 0 | 16 | 3 |
P value = 0.301 (Fisher's exact test), Q value = 0.45
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 142 | 165 | 167 | 23 |
subtype1 | 39 | 37 | 46 | 10 |
subtype2 | 34 | 50 | 46 | 7 |
subtype3 | 69 | 78 | 75 | 6 |
P value = 0.544 (Fisher's exact test), Q value = 0.68
nPatients | 0 | 1 |
---|---|---|
ALL | 225 | 224 |
subtype1 | 58 | 63 |
subtype2 | 60 | 66 |
subtype3 | 107 | 95 |
P value = 0.519 (Fisher's exact test), Q value = 0.66
nPatients | 0 | 1 |
---|---|---|
ALL | 278 | 9 |
subtype1 | 72 | 4 |
subtype2 | 87 | 2 |
subtype3 | 119 | 3 |
P value = 0.974 (Fisher's exact test), Q value = 0.99
nPatients | FEMALE | MALE |
---|---|---|
ALL | 365 | 134 |
subtype1 | 96 | 36 |
subtype2 | 102 | 36 |
subtype3 | 167 | 62 |
P value = 0.376 (Fisher's exact test), Q value = 0.52
nPatients | NO | YES |
---|---|---|
ALL | 180 | 303 |
subtype1 | 40 | 85 |
subtype2 | 53 | 83 |
subtype3 | 87 | 135 |
P value = 0.387 (Fisher's exact test), Q value = 0.53
nPatients | OTHER, SPECIFY | THYROID PAPILLARY CARCINOMA - CLASSICAL/USUAL | THYROID PAPILLARY CARCINOMA - FOLLICULAR (>= 99% FOLLICULAR PATTERNED) | THYROID PAPILLARY CARCINOMA - TALL CELL (>= 50% TALL CELL FEATURES) |
---|---|---|---|---|
ALL | 7 | 356 | 100 | 36 |
subtype1 | 4 | 90 | 30 | 8 |
subtype2 | 1 | 99 | 24 | 14 |
subtype3 | 2 | 167 | 46 | 14 |
P value = 0.664 (Fisher's exact test), Q value = 0.79
nPatients | NO | YES |
---|---|---|
ALL | 420 | 17 |
subtype1 | 114 | 3 |
subtype2 | 113 | 6 |
subtype3 | 193 | 8 |
P value = 0.328 (Fisher's exact test), Q value = 0.48
nPatients | MINIMAL (T3) | MODERATE/ADVANCED (T4A) | NONE | VERY ADVANCED (T4B) |
---|---|---|---|---|
ALL | 132 | 18 | 330 | 1 |
subtype1 | 35 | 6 | 84 | 1 |
subtype2 | 42 | 6 | 84 | 0 |
subtype3 | 55 | 6 | 162 | 0 |
P value = 0.0836 (Fisher's exact test), Q value = 0.17
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 383 | 51 | 4 | 30 |
subtype1 | 94 | 16 | 2 | 13 |
subtype2 | 110 | 10 | 2 | 6 |
subtype3 | 179 | 25 | 0 | 11 |
P value = 0.16 (Kruskal-Wallis (anova)), Q value = 0.28
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 386 | 3.6 (6.0) |
subtype1 | 102 | 3.8 (6.3) |
subtype2 | 109 | 3.9 (5.6) |
subtype3 | 175 | 3.2 (6.1) |
P value = 0.0671 (Fisher's exact test), Q value = 0.14
nPatients | MULTIFOCAL | UNIFOCAL |
---|---|---|
ALL | 225 | 264 |
subtype1 | 71 | 59 |
subtype2 | 56 | 79 |
subtype3 | 98 | 126 |
P value = 0.606 (Kruskal-Wallis (anova)), Q value = 0.75
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 401 | 3.0 (1.6) |
subtype1 | 103 | 3.0 (1.6) |
subtype2 | 115 | 2.8 (1.5) |
subtype3 | 183 | 3.0 (1.6) |
P value = 0.00984 (Fisher's exact test), Q value = 0.026
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 1 | 52 | 27 | 329 |
subtype1 | 0 | 13 | 9 | 82 |
subtype2 | 1 | 6 | 6 | 106 |
subtype3 | 0 | 33 | 12 | 141 |
P value = 0.305 (Fisher's exact test), Q value = 0.45
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 38 | 360 |
subtype1 | 11 | 92 |
subtype2 | 14 | 100 |
subtype3 | 13 | 168 |
Cluster Labels | 1 | 2 | 3 | 4 | 5 |
---|---|---|---|---|---|
Number of samples | 46 | 149 | 85 | 42 | 181 |
P value = 0.218 (logrank test), Q value = 0.36
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 502 | 16 | 0.2 - 178.3 (31.1) |
subtype1 | 46 | 2 | 0.2 - 155.5 (33.2) |
subtype2 | 149 | 5 | 1.1 - 166.6 (23.9) |
subtype3 | 85 | 5 | 2.3 - 178.3 (31.0) |
subtype4 | 41 | 0 | 8.4 - 169.3 (29.6) |
subtype5 | 181 | 4 | 0.9 - 158.8 (34.0) |
P value = 0.0375 (Kruskal-Wallis (anova)), Q value = 0.085
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 503 | 47.3 (15.8) |
subtype1 | 46 | 51.7 (13.8) |
subtype2 | 149 | 49.0 (15.2) |
subtype3 | 85 | 46.8 (17.9) |
subtype4 | 42 | 43.0 (14.8) |
subtype5 | 181 | 45.9 (15.6) |
P value = 4e-05 (Fisher's exact test), Q value = 0.00016
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV | STAGE IVA | STAGE IVC |
---|---|---|---|---|---|---|
ALL | 284 | 51 | 111 | 2 | 47 | 6 |
subtype1 | 19 | 1 | 16 | 0 | 10 | 0 |
subtype2 | 86 | 29 | 26 | 1 | 4 | 2 |
subtype3 | 51 | 2 | 22 | 1 | 8 | 1 |
subtype4 | 25 | 4 | 11 | 0 | 2 | 0 |
subtype5 | 103 | 15 | 36 | 0 | 23 | 3 |
P value = 4e-05 (Fisher's exact test), Q value = 0.00016
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 143 | 166 | 169 | 23 |
subtype1 | 4 | 10 | 26 | 6 |
subtype2 | 52 | 57 | 39 | 1 |
subtype3 | 29 | 24 | 27 | 4 |
subtype4 | 10 | 15 | 17 | 0 |
subtype5 | 48 | 60 | 60 | 12 |
P value = 1e-05 (Fisher's exact test), Q value = 4.7e-05
nPatients | 0 | 1 |
---|---|---|
ALL | 227 | 226 |
subtype1 | 15 | 30 |
subtype2 | 98 | 25 |
subtype3 | 34 | 47 |
subtype4 | 16 | 21 |
subtype5 | 64 | 103 |
P value = 0.779 (Fisher's exact test), Q value = 0.85
nPatients | 0 | 1 |
---|---|---|
ALL | 280 | 9 |
subtype1 | 28 | 0 |
subtype2 | 69 | 3 |
subtype3 | 55 | 1 |
subtype4 | 25 | 0 |
subtype5 | 103 | 5 |
P value = 0.892 (Fisher's exact test), Q value = 0.94
nPatients | FEMALE | MALE |
---|---|---|
ALL | 368 | 135 |
subtype1 | 32 | 14 |
subtype2 | 108 | 41 |
subtype3 | 61 | 24 |
subtype4 | 33 | 9 |
subtype5 | 134 | 47 |
P value = 0.0845 (Fisher's exact test), Q value = 0.17
nPatients | NO | YES |
---|---|---|
ALL | 181 | 306 |
subtype1 | 9 | 37 |
subtype2 | 54 | 88 |
subtype3 | 32 | 49 |
subtype4 | 19 | 22 |
subtype5 | 67 | 110 |
P value = 1e-05 (Fisher's exact test), Q value = 4.7e-05
nPatients | OTHER, SPECIFY | THYROID PAPILLARY CARCINOMA - CLASSICAL/USUAL | THYROID PAPILLARY CARCINOMA - FOLLICULAR (>= 99% FOLLICULAR PATTERNED) | THYROID PAPILLARY CARCINOMA - TALL CELL (>= 50% TALL CELL FEATURES) |
---|---|---|---|---|
ALL | 7 | 358 | 102 | 36 |
subtype1 | 0 | 34 | 0 | 12 |
subtype2 | 2 | 70 | 77 | 0 |
subtype3 | 1 | 68 | 7 | 9 |
subtype4 | 0 | 37 | 3 | 2 |
subtype5 | 4 | 149 | 15 | 13 |
P value = 0.358 (Fisher's exact test), Q value = 0.5
nPatients | NO | YES |
---|---|---|
ALL | 423 | 17 |
subtype1 | 40 | 2 |
subtype2 | 120 | 6 |
subtype3 | 72 | 4 |
subtype4 | 31 | 2 |
subtype5 | 160 | 3 |
P value = 1e-05 (Fisher's exact test), Q value = 4.7e-05
nPatients | MINIMAL (T3) | MODERATE/ADVANCED (T4A) | NONE | VERY ADVANCED (T4B) |
---|---|---|---|---|
ALL | 133 | 18 | 333 | 1 |
subtype1 | 22 | 6 | 17 | 0 |
subtype2 | 21 | 0 | 119 | 0 |
subtype3 | 22 | 3 | 55 | 1 |
subtype4 | 16 | 0 | 24 | 0 |
subtype5 | 52 | 9 | 118 | 0 |
P value = 0.0872 (Fisher's exact test), Q value = 0.17
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 385 | 52 | 4 | 30 |
subtype1 | 33 | 9 | 1 | 2 |
subtype2 | 118 | 8 | 0 | 8 |
subtype3 | 62 | 10 | 1 | 5 |
subtype4 | 36 | 1 | 0 | 1 |
subtype5 | 136 | 24 | 2 | 14 |
P value = 3.83e-08 (Kruskal-Wallis (anova)), Q value = 1.6e-06
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 389 | 3.7 (6.2) |
subtype1 | 42 | 3.6 (4.6) |
subtype2 | 97 | 1.6 (4.3) |
subtype3 | 73 | 4.1 (6.9) |
subtype4 | 32 | 4.0 (7.7) |
subtype5 | 145 | 4.7 (6.6) |
P value = 0.286 (Fisher's exact test), Q value = 0.45
nPatients | MULTIFOCAL | UNIFOCAL |
---|---|---|
ALL | 227 | 266 |
subtype1 | 18 | 28 |
subtype2 | 69 | 77 |
subtype3 | 38 | 45 |
subtype4 | 13 | 27 |
subtype5 | 89 | 89 |
P value = 0.685 (Kruskal-Wallis (anova)), Q value = 0.8
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 403 | 3.0 (1.6) |
subtype1 | 37 | 3.2 (1.6) |
subtype2 | 118 | 3.1 (1.6) |
subtype3 | 68 | 2.9 (1.6) |
subtype4 | 32 | 3.0 (1.7) |
subtype5 | 148 | 2.9 (1.5) |
P value = 0.821 (Fisher's exact test), Q value = 0.87
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 1 | 52 | 27 | 331 |
subtype1 | 1 | 5 | 3 | 33 |
subtype2 | 0 | 11 | 9 | 84 |
subtype3 | 0 | 10 | 4 | 63 |
subtype4 | 0 | 4 | 1 | 33 |
subtype5 | 0 | 22 | 10 | 118 |
P value = 0.39 (Fisher's exact test), Q value = 0.53
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 38 | 362 |
subtype1 | 7 | 33 |
subtype2 | 7 | 97 |
subtype3 | 7 | 68 |
subtype4 | 2 | 31 |
subtype5 | 15 | 133 |
Cluster Labels | 1 | 2 | 3 | 4 |
---|---|---|---|---|
Number of samples | 64 | 64 | 43 | 51 |
P value = 0.272 (logrank test), Q value = 0.43
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 222 | 14 | 1.2 - 178.3 (36.9) |
subtype1 | 64 | 6 | 1.2 - 158.8 (35.5) |
subtype2 | 64 | 2 | 4.0 - 178.3 (41.7) |
subtype3 | 43 | 2 | 3.0 - 166.6 (33.5) |
subtype4 | 51 | 4 | 2.7 - 147.8 (37.5) |
P value = 0.00137 (Kruskal-Wallis (anova)), Q value = 0.0042
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 222 | 48.1 (16.8) |
subtype1 | 64 | 51.8 (14.9) |
subtype2 | 64 | 51.5 (15.1) |
subtype3 | 43 | 43.6 (18.0) |
subtype4 | 51 | 42.8 (18.1) |
P value = 0.00036 (Fisher's exact test), Q value = 0.0012
nPatients | STAGE I | STAGE II | STAGE III | STAGE IVA | STAGE IVC |
---|---|---|---|---|---|
ALL | 117 | 33 | 46 | 20 | 4 |
subtype1 | 32 | 12 | 13 | 3 | 2 |
subtype2 | 22 | 11 | 19 | 12 | 0 |
subtype3 | 30 | 8 | 3 | 2 | 0 |
subtype4 | 33 | 2 | 11 | 3 | 2 |
P value = 0.0121 (Fisher's exact test), Q value = 0.031
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 51 | 83 | 76 | 11 |
subtype1 | 23 | 23 | 16 | 1 |
subtype2 | 12 | 19 | 27 | 6 |
subtype3 | 9 | 22 | 12 | 0 |
subtype4 | 7 | 19 | 21 | 4 |
P value = 1e-05 (Fisher's exact test), Q value = 4.7e-05
nPatients | 0 | 1 |
---|---|---|
ALL | 98 | 95 |
subtype1 | 37 | 19 |
subtype2 | 25 | 31 |
subtype3 | 25 | 11 |
subtype4 | 11 | 34 |
P value = 0.669 (Fisher's exact test), Q value = 0.79
nPatients | 0 | 1 |
---|---|---|
ALL | 118 | 5 |
subtype1 | 38 | 2 |
subtype2 | 35 | 1 |
subtype3 | 21 | 0 |
subtype4 | 24 | 2 |
P value = 0.434 (Fisher's exact test), Q value = 0.56
nPatients | FEMALE | MALE |
---|---|---|
ALL | 154 | 68 |
subtype1 | 44 | 20 |
subtype2 | 47 | 17 |
subtype3 | 32 | 11 |
subtype4 | 31 | 20 |
P value = 0.131 (Fisher's exact test), Q value = 0.25
nPatients | NO | YES |
---|---|---|
ALL | 90 | 128 |
subtype1 | 31 | 31 |
subtype2 | 24 | 40 |
subtype3 | 20 | 22 |
subtype4 | 15 | 35 |
P value = 1e-05 (Fisher's exact test), Q value = 4.7e-05
nPatients | OTHER, SPECIFY | THYROID PAPILLARY CARCINOMA - CLASSICAL/USUAL | THYROID PAPILLARY CARCINOMA - FOLLICULAR (>= 99% FOLLICULAR PATTERNED) | THYROID PAPILLARY CARCINOMA - TALL CELL (>= 50% TALL CELL FEATURES) |
---|---|---|---|---|
ALL | 2 | 158 | 52 | 10 |
subtype1 | 0 | 36 | 27 | 1 |
subtype2 | 0 | 44 | 13 | 7 |
subtype3 | 1 | 32 | 10 | 0 |
subtype4 | 1 | 46 | 2 | 2 |
P value = 0.974 (Fisher's exact test), Q value = 0.99
nPatients | NO | YES |
---|---|---|
ALL | 184 | 11 |
subtype1 | 55 | 4 |
subtype2 | 55 | 3 |
subtype3 | 29 | 2 |
subtype4 | 45 | 2 |
P value = 0.00571 (Fisher's exact test), Q value = 0.016
nPatients | MINIMAL (T3) | MODERATE/ADVANCED (T4A) | NONE |
---|---|---|---|
ALL | 55 | 10 | 149 |
subtype1 | 12 | 1 | 51 |
subtype2 | 22 | 6 | 34 |
subtype3 | 5 | 0 | 32 |
subtype4 | 16 | 3 | 32 |
P value = 0.134 (Fisher's exact test), Q value = 0.25
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 168 | 23 | 2 | 14 |
subtype1 | 50 | 6 | 1 | 6 |
subtype2 | 45 | 12 | 0 | 4 |
subtype3 | 34 | 2 | 0 | 0 |
subtype4 | 39 | 3 | 1 | 4 |
P value = 0.0625 (Kruskal-Wallis (anova)), Q value = 0.13
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 168 | 3.5 (5.8) |
subtype1 | 47 | 3.7 (7.2) |
subtype2 | 50 | 3.0 (4.5) |
subtype3 | 26 | 2.7 (4.4) |
subtype4 | 45 | 4.4 (6.3) |
P value = 0.159 (Fisher's exact test), Q value = 0.28
nPatients | MULTIFOCAL | UNIFOCAL |
---|---|---|
ALL | 100 | 115 |
subtype1 | 34 | 27 |
subtype2 | 22 | 40 |
subtype3 | 20 | 22 |
subtype4 | 24 | 26 |
P value = 0.768 (Kruskal-Wallis (anova)), Q value = 0.85
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 191 | 3.3 (1.6) |
subtype1 | 55 | 3.2 (1.6) |
subtype2 | 52 | 3.4 (1.6) |
subtype3 | 36 | 3.2 (1.3) |
subtype4 | 48 | 3.4 (1.5) |
P value = 0.305 (Fisher's exact test), Q value = 0.45
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 16 | 13 | 149 |
subtype1 | 3 | 7 | 36 |
subtype2 | 3 | 3 | 48 |
subtype3 | 4 | 1 | 28 |
subtype4 | 6 | 2 | 37 |
P value = 0.61 (Fisher's exact test), Q value = 0.75
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 16 | 168 |
subtype1 | 3 | 45 |
subtype2 | 5 | 49 |
subtype3 | 5 | 31 |
subtype4 | 3 | 43 |
Cluster Labels | 1 | 2 | 3 | 4 | 5 | 6 | 7 |
---|---|---|---|---|---|---|---|
Number of samples | 47 | 28 | 33 | 29 | 49 | 27 | 9 |
P value = 0.000176 (logrank test), Q value = 0.00064
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 222 | 14 | 1.2 - 178.3 (36.9) |
subtype1 | 47 | 5 | 1.2 - 166.6 (37.6) |
subtype2 | 28 | 1 | 6.0 - 95.3 (34.3) |
subtype3 | 33 | 0 | 4.0 - 139.0 (48.1) |
subtype4 | 29 | 2 | 3.0 - 155.5 (22.5) |
subtype5 | 49 | 1 | 2.7 - 150.5 (41.5) |
subtype6 | 27 | 1 | 6.0 - 112.8 (34.4) |
subtype7 | 9 | 4 | 17.5 - 178.3 (42.1) |
P value = 0.000996 (Kruskal-Wallis (anova)), Q value = 0.0032
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 222 | 48.1 (16.8) |
subtype1 | 47 | 52.6 (16.2) |
subtype2 | 28 | 49.6 (15.4) |
subtype3 | 33 | 47.6 (15.3) |
subtype4 | 29 | 45.3 (19.2) |
subtype5 | 49 | 40.1 (14.7) |
subtype6 | 27 | 52.2 (16.7) |
subtype7 | 9 | 61.8 (14.9) |
P value = 0.00112 (Fisher's exact test), Q value = 0.0035
nPatients | STAGE I | STAGE II | STAGE III | STAGE IVA | STAGE IVC |
---|---|---|---|---|---|
ALL | 117 | 33 | 46 | 20 | 4 |
subtype1 | 26 | 11 | 6 | 1 | 1 |
subtype2 | 16 | 3 | 7 | 2 | 0 |
subtype3 | 13 | 4 | 11 | 5 | 0 |
subtype4 | 17 | 4 | 7 | 0 | 1 |
subtype5 | 35 | 3 | 6 | 4 | 1 |
subtype6 | 9 | 7 | 7 | 4 | 0 |
subtype7 | 1 | 1 | 2 | 4 | 1 |
P value = 0.00013 (Fisher's exact test), Q value = 0.00048
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 51 | 83 | 76 | 11 |
subtype1 | 16 | 22 | 9 | 0 |
subtype2 | 11 | 9 | 8 | 0 |
subtype3 | 3 | 11 | 17 | 2 |
subtype4 | 4 | 11 | 12 | 1 |
subtype5 | 11 | 21 | 16 | 1 |
subtype6 | 5 | 9 | 11 | 2 |
subtype7 | 1 | 0 | 3 | 5 |
P value = 0.00833 (Fisher's exact test), Q value = 0.022
nPatients | 0 | 1 |
---|---|---|
ALL | 98 | 95 |
subtype1 | 28 | 11 |
subtype2 | 13 | 13 |
subtype3 | 10 | 22 |
subtype4 | 17 | 9 |
subtype5 | 16 | 26 |
subtype6 | 11 | 10 |
subtype7 | 3 | 4 |
P value = 0.756 (Fisher's exact test), Q value = 0.84
nPatients | 0 | 1 |
---|---|---|
ALL | 118 | 5 |
subtype1 | 21 | 1 |
subtype2 | 19 | 0 |
subtype3 | 21 | 1 |
subtype4 | 13 | 1 |
subtype5 | 26 | 1 |
subtype6 | 11 | 0 |
subtype7 | 7 | 1 |
P value = 0.942 (Fisher's exact test), Q value = 0.97
nPatients | FEMALE | MALE |
---|---|---|
ALL | 154 | 68 |
subtype1 | 31 | 16 |
subtype2 | 18 | 10 |
subtype3 | 25 | 8 |
subtype4 | 21 | 8 |
subtype5 | 33 | 16 |
subtype6 | 20 | 7 |
subtype7 | 6 | 3 |
P value = 0.786 (Fisher's exact test), Q value = 0.85
nPatients | NO | YES |
---|---|---|
ALL | 90 | 128 |
subtype1 | 21 | 24 |
subtype2 | 14 | 14 |
subtype3 | 13 | 20 |
subtype4 | 11 | 17 |
subtype5 | 20 | 28 |
subtype6 | 8 | 19 |
subtype7 | 3 | 6 |
P value = 1e-05 (Fisher's exact test), Q value = 4.7e-05
nPatients | OTHER, SPECIFY | THYROID PAPILLARY CARCINOMA - CLASSICAL/USUAL | THYROID PAPILLARY CARCINOMA - FOLLICULAR (>= 99% FOLLICULAR PATTERNED) | THYROID PAPILLARY CARCINOMA - TALL CELL (>= 50% TALL CELL FEATURES) |
---|---|---|---|---|
ALL | 2 | 158 | 52 | 10 |
subtype1 | 0 | 22 | 25 | 0 |
subtype2 | 0 | 22 | 5 | 1 |
subtype3 | 0 | 25 | 0 | 8 |
subtype4 | 0 | 22 | 7 | 0 |
subtype5 | 1 | 46 | 2 | 0 |
subtype6 | 1 | 12 | 13 | 1 |
subtype7 | 0 | 9 | 0 | 0 |
P value = 0.235 (Fisher's exact test), Q value = 0.38
nPatients | NO | YES |
---|---|---|
ALL | 184 | 11 |
subtype1 | 39 | 3 |
subtype2 | 26 | 0 |
subtype3 | 29 | 0 |
subtype4 | 22 | 2 |
subtype5 | 39 | 2 |
subtype6 | 23 | 3 |
subtype7 | 6 | 1 |
P value = 1e-05 (Fisher's exact test), Q value = 4.7e-05
nPatients | MINIMAL (T3) | MODERATE/ADVANCED (T4A) | NONE |
---|---|---|---|
ALL | 55 | 10 | 149 |
subtype1 | 4 | 0 | 42 |
subtype2 | 9 | 0 | 19 |
subtype3 | 15 | 3 | 14 |
subtype4 | 6 | 1 | 18 |
subtype5 | 12 | 0 | 36 |
subtype6 | 6 | 2 | 19 |
subtype7 | 3 | 4 | 1 |
P value = 0.0952 (Fisher's exact test), Q value = 0.19
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 168 | 23 | 2 | 14 |
subtype1 | 37 | 5 | 0 | 3 |
subtype2 | 22 | 3 | 0 | 2 |
subtype3 | 24 | 7 | 0 | 0 |
subtype4 | 19 | 2 | 2 | 1 |
subtype5 | 39 | 3 | 0 | 3 |
subtype6 | 23 | 1 | 0 | 3 |
subtype7 | 4 | 2 | 0 | 2 |
P value = 0.4 (Kruskal-Wallis (anova)), Q value = 0.53
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 168 | 3.5 (5.8) |
subtype1 | 30 | 3.0 (6.7) |
subtype2 | 25 | 3.9 (7.0) |
subtype3 | 27 | 3.4 (3.8) |
subtype4 | 22 | 2.8 (4.2) |
subtype5 | 38 | 4.0 (6.6) |
subtype6 | 19 | 3.7 (5.9) |
subtype7 | 7 | 4.0 (5.3) |
P value = 0.18 (Fisher's exact test), Q value = 0.31
nPatients | MULTIFOCAL | UNIFOCAL |
---|---|---|
ALL | 100 | 115 |
subtype1 | 27 | 17 |
subtype2 | 12 | 16 |
subtype3 | 12 | 20 |
subtype4 | 12 | 17 |
subtype5 | 25 | 22 |
subtype6 | 10 | 16 |
subtype7 | 2 | 7 |
P value = 0.0203 (Kruskal-Wallis (anova)), Q value = 0.051
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 191 | 3.3 (1.6) |
subtype1 | 38 | 3.4 (1.5) |
subtype2 | 27 | 2.6 (1.6) |
subtype3 | 29 | 3.3 (1.3) |
subtype4 | 24 | 3.6 (1.5) |
subtype5 | 45 | 3.1 (1.5) |
subtype6 | 22 | 3.3 (1.6) |
subtype7 | 6 | 5.2 (1.8) |
P value = 0.297 (Fisher's exact test), Q value = 0.45
nPatients | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|
ALL | 16 | 13 | 149 |
subtype1 | 1 | 6 | 25 |
subtype2 | 2 | 1 | 19 |
subtype3 | 3 | 0 | 28 |
subtype4 | 2 | 1 | 20 |
subtype5 | 7 | 2 | 33 |
subtype6 | 1 | 2 | 16 |
subtype7 | 0 | 1 | 8 |
P value = 0.937 (Fisher's exact test), Q value = 0.96
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 16 | 168 |
subtype1 | 2 | 32 |
subtype2 | 1 | 23 |
subtype3 | 3 | 28 |
subtype4 | 2 | 22 |
subtype5 | 5 | 38 |
subtype6 | 2 | 17 |
subtype7 | 1 | 8 |
Cluster Labels | 1 | 2 | 3 | 4 |
---|---|---|---|---|
Number of samples | 158 | 169 | 59 | 115 |
P value = 0.181 (logrank test), Q value = 0.31
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 500 | 16 | 0.2 - 178.3 (31.0) |
subtype1 | 158 | 7 | 2.6 - 178.3 (31.2) |
subtype2 | 169 | 7 | 0.2 - 166.6 (25.5) |
subtype3 | 59 | 0 | 2.3 - 157.2 (30.1) |
subtype4 | 114 | 2 | 0.9 - 169.3 (35.0) |
P value = 0.0419 (Kruskal-Wallis (anova)), Q value = 0.092
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 501 | 47.3 (15.8) |
subtype1 | 158 | 48.4 (16.0) |
subtype2 | 169 | 49.1 (15.5) |
subtype3 | 59 | 43.1 (17.2) |
subtype4 | 115 | 45.2 (14.7) |
P value = 2e-05 (Fisher's exact test), Q value = 8.5e-05
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV | STAGE IVA | STAGE IVC |
---|---|---|---|---|---|---|
ALL | 283 | 51 | 110 | 2 | 47 | 6 |
subtype1 | 78 | 6 | 44 | 1 | 27 | 2 |
subtype2 | 99 | 29 | 31 | 1 | 6 | 2 |
subtype3 | 41 | 1 | 12 | 0 | 5 | 0 |
subtype4 | 65 | 15 | 23 | 0 | 9 | 2 |
P value = 1e-05 (Fisher's exact test), Q value = 4.7e-05
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 142 | 165 | 169 | 23 |
subtype1 | 26 | 42 | 75 | 15 |
subtype2 | 57 | 61 | 48 | 2 |
subtype3 | 26 | 15 | 15 | 2 |
subtype4 | 33 | 47 | 31 | 4 |
P value = 1e-05 (Fisher's exact test), Q value = 4.7e-05
nPatients | 0 | 1 |
---|---|---|
ALL | 226 | 225 |
subtype1 | 47 | 97 |
subtype2 | 108 | 34 |
subtype3 | 22 | 37 |
subtype4 | 49 | 57 |
P value = 0.754 (Fisher's exact test), Q value = 0.84
nPatients | 0 | 1 |
---|---|---|
ALL | 279 | 9 |
subtype1 | 86 | 3 |
subtype2 | 82 | 3 |
subtype3 | 41 | 0 |
subtype4 | 70 | 3 |
P value = 0.717 (Fisher's exact test), Q value = 0.82
nPatients | FEMALE | MALE |
---|---|---|
ALL | 366 | 135 |
subtype1 | 115 | 43 |
subtype2 | 119 | 50 |
subtype3 | 44 | 15 |
subtype4 | 88 | 27 |
P value = 0.352 (Fisher's exact test), Q value = 0.49
nPatients | NO | YES |
---|---|---|
ALL | 180 | 305 |
subtype1 | 49 | 106 |
subtype2 | 64 | 96 |
subtype3 | 24 | 33 |
subtype4 | 43 | 70 |
P value = 1e-05 (Fisher's exact test), Q value = 4.7e-05
nPatients | OTHER, SPECIFY | THYROID PAPILLARY CARCINOMA - CLASSICAL/USUAL | THYROID PAPILLARY CARCINOMA - FOLLICULAR (>= 99% FOLLICULAR PATTERNED) | THYROID PAPILLARY CARCINOMA - TALL CELL (>= 50% TALL CELL FEATURES) |
---|---|---|---|---|
ALL | 7 | 357 | 102 | 35 |
subtype1 | 3 | 128 | 3 | 24 |
subtype2 | 3 | 80 | 84 | 2 |
subtype3 | 0 | 50 | 2 | 7 |
subtype4 | 1 | 99 | 13 | 2 |
P value = 1 (Fisher's exact test), Q value = 1
nPatients | NO | YES |
---|---|---|
ALL | 421 | 17 |
subtype1 | 137 | 5 |
subtype2 | 138 | 6 |
subtype3 | 47 | 2 |
subtype4 | 99 | 4 |
P value = 1e-05 (Fisher's exact test), Q value = 4.7e-05
nPatients | MINIMAL (T3) | MODERATE/ADVANCED (T4A) | NONE | VERY ADVANCED (T4B) |
---|---|---|---|---|
ALL | 133 | 18 | 331 | 1 |
subtype1 | 65 | 14 | 74 | 1 |
subtype2 | 27 | 1 | 132 | 0 |
subtype3 | 13 | 2 | 41 | 0 |
subtype4 | 28 | 1 | 84 | 0 |
P value = 0.0618 (Fisher's exact test), Q value = 0.13
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 383 | 52 | 4 | 30 |
subtype1 | 119 | 26 | 1 | 8 |
subtype2 | 134 | 10 | 0 | 9 |
subtype3 | 40 | 7 | 1 | 5 |
subtype4 | 90 | 9 | 2 | 8 |
P value = 7.41e-08 (Kruskal-Wallis (anova)), Q value = 2.5e-06
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 387 | 3.7 (6.2) |
subtype1 | 132 | 4.3 (6.2) |
subtype2 | 114 | 2.1 (5.2) |
subtype3 | 51 | 5.2 (7.4) |
subtype4 | 90 | 3.8 (6.3) |
P value = 0.121 (Fisher's exact test), Q value = 0.23
nPatients | MULTIFOCAL | UNIFOCAL |
---|---|---|
ALL | 226 | 265 |
subtype1 | 60 | 96 |
subtype2 | 79 | 87 |
subtype3 | 29 | 28 |
subtype4 | 58 | 54 |
P value = 0.0784 (Kruskal-Wallis (anova)), Q value = 0.16
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 402 | 3.0 (1.6) |
subtype1 | 134 | 3.2 (1.6) |
subtype2 | 135 | 3.0 (1.6) |
subtype3 | 41 | 2.6 (1.6) |
subtype4 | 92 | 2.9 (1.5) |
P value = 0.578 (Fisher's exact test), Q value = 0.72
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 1 | 51 | 27 | 331 |
subtype1 | 1 | 14 | 11 | 114 |
subtype2 | 0 | 13 | 9 | 98 |
subtype3 | 0 | 10 | 1 | 43 |
subtype4 | 0 | 14 | 6 | 76 |
P value = 0.00355 (Fisher's exact test), Q value = 0.01
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 38 | 360 |
subtype1 | 23 | 113 |
subtype2 | 9 | 108 |
subtype3 | 3 | 51 |
subtype4 | 3 | 88 |
Cluster Labels | 1 | 2 | 3 | 4 | 5 |
---|---|---|---|---|---|
Number of samples | 105 | 136 | 86 | 96 | 78 |
P value = 0.411 (logrank test), Q value = 0.54
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 500 | 16 | 0.2 - 178.3 (31.0) |
subtype1 | 105 | 5 | 2.8 - 178.3 (34.4) |
subtype2 | 136 | 6 | 0.2 - 166.6 (23.5) |
subtype3 | 86 | 1 | 2.3 - 142.5 (31.4) |
subtype4 | 95 | 2 | 0.9 - 169.3 (34.9) |
subtype5 | 78 | 2 | 2.6 - 150.5 (28.0) |
P value = 0.00239 (Kruskal-Wallis (anova)), Q value = 0.007
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 501 | 47.3 (15.8) |
subtype1 | 105 | 51.0 (16.1) |
subtype2 | 136 | 49.7 (16.0) |
subtype3 | 86 | 44.5 (15.1) |
subtype4 | 96 | 45.3 (14.6) |
subtype5 | 78 | 43.5 (15.8) |
P value = 1e-05 (Fisher's exact test), Q value = 4.7e-05
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV | STAGE IVA | STAGE IVC |
---|---|---|---|---|---|---|
ALL | 283 | 51 | 110 | 2 | 47 | 6 |
subtype1 | 46 | 2 | 39 | 1 | 16 | 1 |
subtype2 | 77 | 29 | 22 | 1 | 4 | 2 |
subtype3 | 57 | 3 | 18 | 0 | 8 | 0 |
subtype4 | 54 | 12 | 19 | 0 | 8 | 2 |
subtype5 | 49 | 5 | 12 | 0 | 11 | 1 |
P value = 1e-05 (Fisher's exact test), Q value = 4.7e-05
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 142 | 165 | 169 | 23 |
subtype1 | 17 | 21 | 57 | 10 |
subtype2 | 43 | 55 | 36 | 2 |
subtype3 | 38 | 22 | 23 | 1 |
subtype4 | 26 | 41 | 25 | 4 |
subtype5 | 18 | 26 | 28 | 6 |
P value = 1e-05 (Fisher's exact test), Q value = 4.7e-05
nPatients | 0 | 1 |
---|---|---|
ALL | 226 | 225 |
subtype1 | 29 | 68 |
subtype2 | 91 | 19 |
subtype3 | 38 | 45 |
subtype4 | 43 | 45 |
subtype5 | 25 | 48 |
P value = 0.402 (Fisher's exact test), Q value = 0.53
nPatients | 0 | 1 |
---|---|---|
ALL | 279 | 9 |
subtype1 | 56 | 1 |
subtype2 | 57 | 3 |
subtype3 | 60 | 0 |
subtype4 | 58 | 3 |
subtype5 | 48 | 2 |
P value = 0.174 (Fisher's exact test), Q value = 0.3
nPatients | FEMALE | MALE |
---|---|---|
ALL | 366 | 135 |
subtype1 | 84 | 21 |
subtype2 | 96 | 40 |
subtype3 | 61 | 25 |
subtype4 | 74 | 22 |
subtype5 | 51 | 27 |
P value = 0.157 (Fisher's exact test), Q value = 0.28
nPatients | NO | YES |
---|---|---|
ALL | 180 | 305 |
subtype1 | 30 | 74 |
subtype2 | 47 | 83 |
subtype3 | 38 | 43 |
subtype4 | 37 | 57 |
subtype5 | 28 | 48 |
P value = 1e-05 (Fisher's exact test), Q value = 4.7e-05
nPatients | OTHER, SPECIFY | THYROID PAPILLARY CARCINOMA - CLASSICAL/USUAL | THYROID PAPILLARY CARCINOMA - FOLLICULAR (>= 99% FOLLICULAR PATTERNED) | THYROID PAPILLARY CARCINOMA - TALL CELL (>= 50% TALL CELL FEATURES) |
---|---|---|---|---|
ALL | 7 | 357 | 102 | 35 |
subtype1 | 1 | 79 | 2 | 23 |
subtype2 | 2 | 57 | 77 | 0 |
subtype3 | 1 | 69 | 10 | 6 |
subtype4 | 0 | 83 | 11 | 2 |
subtype5 | 3 | 69 | 2 | 4 |
P value = 0.252 (Fisher's exact test), Q value = 0.4
nPatients | NO | YES |
---|---|---|
ALL | 421 | 17 |
subtype1 | 95 | 3 |
subtype2 | 111 | 5 |
subtype3 | 66 | 6 |
subtype4 | 85 | 1 |
subtype5 | 64 | 2 |
P value = 1e-05 (Fisher's exact test), Q value = 4.7e-05
nPatients | MINIMAL (T3) | MODERATE/ADVANCED (T4A) | NONE | VERY ADVANCED (T4B) |
---|---|---|---|---|
ALL | 133 | 18 | 331 | 1 |
subtype1 | 53 | 10 | 38 | 1 |
subtype2 | 16 | 1 | 110 | 0 |
subtype3 | 20 | 1 | 62 | 0 |
subtype4 | 22 | 1 | 71 | 0 |
subtype5 | 22 | 5 | 50 | 0 |
P value = 0.0194 (Fisher's exact test), Q value = 0.049
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 383 | 52 | 4 | 30 |
subtype1 | 70 | 23 | 2 | 6 |
subtype2 | 104 | 10 | 0 | 8 |
subtype3 | 70 | 4 | 0 | 6 |
subtype4 | 76 | 8 | 2 | 6 |
subtype5 | 63 | 7 | 0 | 4 |
P value = 8.8e-09 (Kruskal-Wallis (anova)), Q value = 5e-07
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 387 | 3.7 (6.2) |
subtype1 | 92 | 4.7 (6.6) |
subtype2 | 87 | 1.4 (3.5) |
subtype3 | 72 | 4.8 (8.5) |
subtype4 | 73 | 3.8 (6.2) |
subtype5 | 63 | 3.8 (4.6) |
P value = 0.242 (Fisher's exact test), Q value = 0.39
nPatients | MULTIFOCAL | UNIFOCAL |
---|---|---|
ALL | 226 | 265 |
subtype1 | 39 | 66 |
subtype2 | 64 | 69 |
subtype3 | 43 | 41 |
subtype4 | 47 | 46 |
subtype5 | 33 | 43 |
P value = 0.00195 (Kruskal-Wallis (anova)), Q value = 0.0058
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 402 | 3.0 (1.6) |
subtype1 | 93 | 3.1 (1.5) |
subtype2 | 112 | 3.2 (1.5) |
subtype3 | 62 | 2.3 (1.5) |
subtype4 | 76 | 2.9 (1.5) |
subtype5 | 59 | 3.2 (1.8) |
P value = 0.001 (Fisher's exact test), Q value = 0.0032
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 1 | 51 | 27 | 331 |
subtype1 | 1 | 4 | 11 | 77 |
subtype2 | 0 | 7 | 8 | 75 |
subtype3 | 0 | 17 | 1 | 61 |
subtype4 | 0 | 12 | 6 | 60 |
subtype5 | 0 | 11 | 1 | 58 |
P value = 0.0307 (Fisher's exact test), Q value = 0.071
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 38 | 360 |
subtype1 | 15 | 77 |
subtype2 | 9 | 82 |
subtype3 | 3 | 72 |
subtype4 | 3 | 71 |
subtype5 | 8 | 58 |
Cluster Labels | 1 | 2 | 3 | 4 |
---|---|---|---|---|
Number of samples | 166 | 147 | 120 | 69 |
P value = 0.152 (logrank test), Q value = 0.28
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 501 | 16 | 0.2 - 178.3 (31.0) |
subtype1 | 166 | 9 | 2.3 - 158.8 (31.2) |
subtype2 | 147 | 4 | 1.1 - 166.6 (29.1) |
subtype3 | 119 | 1 | 0.2 - 169.3 (30.0) |
subtype4 | 69 | 2 | 2.7 - 178.3 (42.1) |
P value = 0.111 (Kruskal-Wallis (anova)), Q value = 0.21
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 502 | 47.3 (15.8) |
subtype1 | 166 | 49.6 (15.9) |
subtype2 | 147 | 46.8 (16.3) |
subtype3 | 120 | 46.3 (14.6) |
subtype4 | 69 | 44.6 (15.8) |
P value = 1e-05 (Fisher's exact test), Q value = 4.7e-05
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV | STAGE IVA | STAGE IVC |
---|---|---|---|---|---|---|
ALL | 283 | 51 | 111 | 2 | 47 | 6 |
subtype1 | 80 | 4 | 53 | 1 | 25 | 2 |
subtype2 | 92 | 23 | 24 | 1 | 4 | 2 |
subtype3 | 72 | 15 | 21 | 0 | 10 | 2 |
subtype4 | 39 | 9 | 13 | 0 | 8 | 0 |
P value = 6e-05 (Fisher's exact test), Q value = 0.00023
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 143 | 166 | 168 | 23 |
subtype1 | 51 | 34 | 65 | 14 |
subtype2 | 45 | 62 | 39 | 1 |
subtype3 | 35 | 45 | 35 | 5 |
subtype4 | 12 | 25 | 29 | 3 |
P value = 1e-05 (Fisher's exact test), Q value = 4.7e-05
nPatients | 0 | 1 |
---|---|---|
ALL | 227 | 225 |
subtype1 | 57 | 103 |
subtype2 | 93 | 26 |
subtype3 | 47 | 63 |
subtype4 | 30 | 33 |
P value = 0.663 (Fisher's exact test), Q value = 0.79
nPatients | 0 | 1 |
---|---|---|
ALL | 279 | 9 |
subtype1 | 113 | 2 |
subtype2 | 65 | 3 |
subtype3 | 69 | 3 |
subtype4 | 32 | 1 |
P value = 0.986 (Fisher's exact test), Q value = 0.99
nPatients | FEMALE | MALE |
---|---|---|
ALL | 367 | 135 |
subtype1 | 121 | 45 |
subtype2 | 106 | 41 |
subtype3 | 89 | 31 |
subtype4 | 51 | 18 |
P value = 0.808 (Fisher's exact test), Q value = 0.86
nPatients | NO | YES |
---|---|---|
ALL | 181 | 305 |
subtype1 | 55 | 103 |
subtype2 | 52 | 90 |
subtype3 | 46 | 71 |
subtype4 | 28 | 41 |
P value = 1e-05 (Fisher's exact test), Q value = 4.7e-05
nPatients | OTHER, SPECIFY | THYROID PAPILLARY CARCINOMA - CLASSICAL/USUAL | THYROID PAPILLARY CARCINOMA - FOLLICULAR (>= 99% FOLLICULAR PATTERNED) | THYROID PAPILLARY CARCINOMA - TALL CELL (>= 50% TALL CELL FEATURES) |
---|---|---|---|---|
ALL | 7 | 357 | 102 | 36 |
subtype1 | 3 | 130 | 8 | 25 |
subtype2 | 2 | 66 | 79 | 0 |
subtype3 | 1 | 107 | 6 | 6 |
subtype4 | 1 | 54 | 9 | 5 |
P value = 0.858 (Fisher's exact test), Q value = 0.91
nPatients | NO | YES |
---|---|---|
ALL | 422 | 17 |
subtype1 | 140 | 5 |
subtype2 | 124 | 4 |
subtype3 | 99 | 5 |
subtype4 | 59 | 3 |
P value = 2e-05 (Fisher's exact test), Q value = 8.5e-05
nPatients | MINIMAL (T3) | MODERATE/ADVANCED (T4A) | NONE | VERY ADVANCED (T4B) |
---|---|---|---|---|
ALL | 132 | 18 | 333 | 1 |
subtype1 | 57 | 13 | 89 | 1 |
subtype2 | 22 | 0 | 118 | 0 |
subtype3 | 33 | 3 | 81 | 0 |
subtype4 | 20 | 2 | 45 | 0 |
P value = 0.306 (Fisher's exact test), Q value = 0.45
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 384 | 52 | 4 | 30 |
subtype1 | 119 | 24 | 2 | 12 |
subtype2 | 116 | 9 | 0 | 10 |
subtype3 | 94 | 13 | 1 | 5 |
subtype4 | 55 | 6 | 1 | 3 |
P value = 3.59e-09 (Kruskal-Wallis (anova)), Q value = 3.6e-07
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 388 | 3.6 (6.2) |
subtype1 | 138 | 5.3 (7.5) |
subtype2 | 97 | 1.5 (3.2) |
subtype3 | 96 | 3.8 (6.5) |
subtype4 | 57 | 2.9 (4.7) |
P value = 0.0205 (Fisher's exact test), Q value = 0.051
nPatients | MULTIFOCAL | UNIFOCAL |
---|---|---|
ALL | 226 | 266 |
subtype1 | 77 | 88 |
subtype2 | 62 | 80 |
subtype3 | 65 | 52 |
subtype4 | 22 | 46 |
P value = 0.0298 (Kruskal-Wallis (anova)), Q value = 0.069
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 402 | 3.0 (1.6) |
subtype1 | 130 | 2.8 (1.7) |
subtype2 | 121 | 3.1 (1.5) |
subtype3 | 97 | 2.8 (1.5) |
subtype4 | 54 | 3.4 (1.6) |
P value = 0.0278 (Fisher's exact test), Q value = 0.067
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 1 | 52 | 27 | 331 |
subtype1 | 0 | 24 | 8 | 119 |
subtype2 | 0 | 9 | 10 | 84 |
subtype3 | 1 | 16 | 8 | 70 |
subtype4 | 0 | 3 | 1 | 58 |
P value = 0.307 (Fisher's exact test), Q value = 0.45
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 38 | 361 |
subtype1 | 12 | 131 |
subtype2 | 9 | 94 |
subtype3 | 7 | 85 |
subtype4 | 10 | 51 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 179 | 130 | 193 |
P value = 0.00998 (logrank test), Q value = 0.026
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 501 | 16 | 0.2 - 178.3 (31.0) |
subtype1 | 179 | 10 | 2.3 - 178.3 (31.5) |
subtype2 | 130 | 5 | 1.1 - 166.6 (23.3) |
subtype3 | 192 | 1 | 0.2 - 169.3 (33.2) |
P value = 0.00138 (Kruskal-Wallis (anova)), Q value = 0.0042
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 502 | 47.3 (15.8) |
subtype1 | 179 | 49.7 (16.2) |
subtype2 | 130 | 49.1 (15.5) |
subtype3 | 193 | 43.9 (15.0) |
P value = 1e-05 (Fisher's exact test), Q value = 4.7e-05
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV | STAGE IVA | STAGE IVC |
---|---|---|---|---|---|---|
ALL | 283 | 51 | 111 | 2 | 47 | 6 |
subtype1 | 88 | 5 | 57 | 1 | 25 | 2 |
subtype2 | 75 | 27 | 20 | 1 | 4 | 2 |
subtype3 | 120 | 19 | 34 | 0 | 18 | 2 |
P value = 2e-05 (Fisher's exact test), Q value = 8.5e-05
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 143 | 166 | 168 | 23 |
subtype1 | 55 | 36 | 71 | 15 |
subtype2 | 41 | 53 | 35 | 1 |
subtype3 | 47 | 77 | 62 | 7 |
P value = 1e-05 (Fisher's exact test), Q value = 4.7e-05
nPatients | 0 | 1 |
---|---|---|
ALL | 227 | 225 |
subtype1 | 66 | 103 |
subtype2 | 86 | 19 |
subtype3 | 75 | 103 |
P value = 0.334 (Fisher's exact test), Q value = 0.48
nPatients | 0 | 1 |
---|---|---|
ALL | 279 | 9 |
subtype1 | 124 | 2 |
subtype2 | 55 | 3 |
subtype3 | 100 | 4 |
P value = 0.638 (Fisher's exact test), Q value = 0.77
nPatients | FEMALE | MALE |
---|---|---|
ALL | 367 | 135 |
subtype1 | 135 | 44 |
subtype2 | 92 | 38 |
subtype3 | 140 | 53 |
P value = 0.744 (Fisher's exact test), Q value = 0.84
nPatients | NO | YES |
---|---|---|
ALL | 181 | 305 |
subtype1 | 68 | 104 |
subtype2 | 44 | 80 |
subtype3 | 69 | 121 |
P value = 1e-05 (Fisher's exact test), Q value = 4.7e-05
nPatients | OTHER, SPECIFY | THYROID PAPILLARY CARCINOMA - CLASSICAL/USUAL | THYROID PAPILLARY CARCINOMA - FOLLICULAR (>= 99% FOLLICULAR PATTERNED) | THYROID PAPILLARY CARCINOMA - TALL CELL (>= 50% TALL CELL FEATURES) |
---|---|---|---|---|
ALL | 7 | 357 | 102 | 36 |
subtype1 | 3 | 141 | 9 | 26 |
subtype2 | 2 | 51 | 77 | 0 |
subtype3 | 2 | 165 | 16 | 10 |
P value = 0.905 (Fisher's exact test), Q value = 0.94
nPatients | NO | YES |
---|---|---|
ALL | 422 | 17 |
subtype1 | 153 | 6 |
subtype2 | 107 | 5 |
subtype3 | 162 | 6 |
P value = 1e-05 (Fisher's exact test), Q value = 4.7e-05
nPatients | MINIMAL (T3) | MODERATE/ADVANCED (T4A) | NONE | VERY ADVANCED (T4B) |
---|---|---|---|---|
ALL | 132 | 18 | 333 | 1 |
subtype1 | 67 | 14 | 91 | 1 |
subtype2 | 15 | 0 | 107 | 0 |
subtype3 | 50 | 4 | 135 | 0 |
P value = 0.192 (Fisher's exact test), Q value = 0.33
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 384 | 52 | 4 | 30 |
subtype1 | 129 | 26 | 3 | 13 |
subtype2 | 101 | 9 | 0 | 7 |
subtype3 | 154 | 17 | 1 | 10 |
P value = 4.26e-09 (Kruskal-Wallis (anova)), Q value = 3.6e-07
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 388 | 3.6 (6.2) |
subtype1 | 144 | 4.7 (6.4) |
subtype2 | 85 | 1.7 (4.6) |
subtype3 | 159 | 3.8 (6.5) |
P value = 0.608 (Fisher's exact test), Q value = 0.75
nPatients | MULTIFOCAL | UNIFOCAL |
---|---|---|
ALL | 226 | 266 |
subtype1 | 76 | 101 |
subtype2 | 61 | 67 |
subtype3 | 89 | 98 |
P value = 0.0378 (Kruskal-Wallis (anova)), Q value = 0.085
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 402 | 3.0 (1.6) |
subtype1 | 139 | 2.8 (1.6) |
subtype2 | 109 | 3.2 (1.6) |
subtype3 | 154 | 3.0 (1.5) |
P value = 0.2 (Fisher's exact test), Q value = 0.34
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 1 | 52 | 27 | 331 |
subtype1 | 0 | 26 | 7 | 131 |
subtype2 | 0 | 6 | 8 | 71 |
subtype3 | 1 | 20 | 12 | 129 |
P value = 0.798 (Fisher's exact test), Q value = 0.86
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 38 | 361 |
subtype1 | 13 | 143 |
subtype2 | 8 | 76 |
subtype3 | 17 | 142 |
Cluster Labels | 1 | 2 | 3 | 4 |
---|---|---|---|---|
Number of samples | 133 | 126 | 108 | 105 |
P value = 0.00375 (logrank test), Q value = 0.01
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 471 | 16 | 0.9 - 178.3 (31.0) |
subtype1 | 133 | 10 | 2.3 - 178.3 (31.3) |
subtype2 | 126 | 5 | 1.1 - 169.3 (24.3) |
subtype3 | 108 | 0 | 3.0 - 158.8 (42.5) |
subtype4 | 104 | 1 | 0.9 - 157.2 (30.1) |
P value = 0.000587 (Kruskal-Wallis (anova)), Q value = 0.002
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 472 | 47.3 (15.8) |
subtype1 | 133 | 49.3 (17.3) |
subtype2 | 126 | 49.2 (15.9) |
subtype3 | 108 | 41.9 (14.8) |
subtype4 | 105 | 48.1 (13.2) |
P value = 2e-05 (Fisher's exact test), Q value = 8.5e-05
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV | STAGE IVA | STAGE IVC |
---|---|---|---|---|---|---|
ALL | 267 | 49 | 104 | 2 | 42 | 6 |
subtype1 | 70 | 4 | 38 | 1 | 18 | 2 |
subtype2 | 71 | 26 | 22 | 1 | 3 | 2 |
subtype3 | 72 | 11 | 13 | 0 | 10 | 1 |
subtype4 | 54 | 8 | 31 | 0 | 11 | 1 |
P value = 0.00076 (Fisher's exact test), Q value = 0.0025
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 136 | 156 | 156 | 22 |
subtype1 | 39 | 28 | 51 | 14 |
subtype2 | 38 | 51 | 36 | 1 |
subtype3 | 26 | 44 | 33 | 5 |
subtype4 | 33 | 33 | 36 | 2 |
P value = 1e-05 (Fisher's exact test), Q value = 4.7e-05
nPatients | 0 | 1 |
---|---|---|
ALL | 213 | 212 |
subtype1 | 49 | 79 |
subtype2 | 83 | 19 |
subtype3 | 43 | 54 |
subtype4 | 38 | 60 |
P value = 0.406 (Fisher's exact test), Q value = 0.53
nPatients | 0 | 1 |
---|---|---|
ALL | 263 | 9 |
subtype1 | 91 | 2 |
subtype2 | 55 | 3 |
subtype3 | 48 | 3 |
subtype4 | 69 | 1 |
P value = 0.701 (Fisher's exact test), Q value = 0.82
nPatients | FEMALE | MALE |
---|---|---|
ALL | 345 | 127 |
subtype1 | 99 | 34 |
subtype2 | 87 | 39 |
subtype3 | 80 | 28 |
subtype4 | 79 | 26 |
P value = 0.906 (Fisher's exact test), Q value = 0.94
nPatients | NO | YES |
---|---|---|
ALL | 172 | 284 |
subtype1 | 50 | 77 |
subtype2 | 46 | 75 |
subtype3 | 41 | 66 |
subtype4 | 35 | 66 |
P value = 1e-05 (Fisher's exact test), Q value = 4.7e-05
nPatients | OTHER, SPECIFY | THYROID PAPILLARY CARCINOMA - CLASSICAL/USUAL | THYROID PAPILLARY CARCINOMA - FOLLICULAR (>= 99% FOLLICULAR PATTERNED) | THYROID PAPILLARY CARCINOMA - TALL CELL (>= 50% TALL CELL FEATURES) |
---|---|---|---|---|
ALL | 7 | 341 | 92 | 32 |
subtype1 | 2 | 105 | 6 | 20 |
subtype2 | 1 | 54 | 71 | 0 |
subtype3 | 1 | 93 | 8 | 6 |
subtype4 | 3 | 89 | 7 | 6 |
P value = 0.0293 (Fisher's exact test), Q value = 0.069
nPatients | NO | YES |
---|---|---|
ALL | 397 | 16 |
subtype1 | 113 | 3 |
subtype2 | 101 | 7 |
subtype3 | 89 | 6 |
subtype4 | 94 | 0 |
P value = 3e-05 (Fisher's exact test), Q value = 0.00012
nPatients | MINIMAL (T3) | MODERATE/ADVANCED (T4A) | NONE | VERY ADVANCED (T4B) |
---|---|---|---|---|
ALL | 125 | 17 | 312 | 1 |
subtype1 | 46 | 12 | 68 | 1 |
subtype2 | 21 | 0 | 98 | 0 |
subtype3 | 26 | 3 | 77 | 0 |
subtype4 | 32 | 2 | 69 | 0 |
P value = 0.426 (Fisher's exact test), Q value = 0.55
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 360 | 49 | 4 | 29 |
subtype1 | 96 | 20 | 1 | 7 |
subtype2 | 96 | 9 | 0 | 8 |
subtype3 | 85 | 8 | 2 | 9 |
subtype4 | 83 | 12 | 1 | 5 |
P value = 2.8e-07 (Kruskal-Wallis (anova)), Q value = 6.8e-06
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 363 | 3.7 (6.2) |
subtype1 | 110 | 4.6 (6.3) |
subtype2 | 79 | 1.4 (3.2) |
subtype3 | 84 | 3.6 (5.0) |
subtype4 | 90 | 4.7 (8.1) |
P value = 0.348 (Fisher's exact test), Q value = 0.49
nPatients | MULTIFOCAL | UNIFOCAL |
---|---|---|
ALL | 215 | 249 |
subtype1 | 62 | 70 |
subtype2 | 59 | 64 |
subtype3 | 41 | 64 |
subtype4 | 53 | 51 |
P value = 0.109 (Kruskal-Wallis (anova)), Q value = 0.21
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 378 | 3.0 (1.6) |
subtype1 | 98 | 2.8 (1.7) |
subtype2 | 103 | 3.2 (1.6) |
subtype3 | 91 | 3.1 (1.5) |
subtype4 | 86 | 2.8 (1.6) |
P value = 0.0445 (Fisher's exact test), Q value = 0.097
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 1 | 49 | 26 | 313 |
subtype1 | 0 | 19 | 4 | 99 |
subtype2 | 0 | 7 | 10 | 69 |
subtype3 | 0 | 8 | 4 | 81 |
subtype4 | 1 | 15 | 8 | 64 |
P value = 0.715 (Fisher's exact test), Q value = 0.82
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 35 | 343 |
subtype1 | 9 | 111 |
subtype2 | 7 | 79 |
subtype3 | 11 | 82 |
subtype4 | 8 | 71 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 164 | 122 | 186 |
P value = 0.00358 (logrank test), Q value = 0.01
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 471 | 16 | 0.9 - 178.3 (31.0) |
subtype1 | 164 | 10 | 2.3 - 178.3 (31.4) |
subtype2 | 122 | 5 | 1.1 - 166.6 (22.9) |
subtype3 | 185 | 1 | 0.9 - 169.3 (33.2) |
P value = 0.000305 (Kruskal-Wallis (anova)), Q value = 0.0011
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 472 | 47.3 (15.8) |
subtype1 | 164 | 50.0 (16.5) |
subtype2 | 122 | 49.4 (15.9) |
subtype3 | 186 | 43.5 (14.2) |
P value = 1e-05 (Fisher's exact test), Q value = 4.7e-05
nPatients | STAGE I | STAGE II | STAGE III | STAGE IV | STAGE IVA | STAGE IVC |
---|---|---|---|---|---|---|
ALL | 267 | 49 | 104 | 2 | 42 | 6 |
subtype1 | 77 | 4 | 58 | 1 | 22 | 2 |
subtype2 | 67 | 27 | 21 | 1 | 3 | 2 |
subtype3 | 123 | 18 | 25 | 0 | 17 | 2 |
P value = 6e-05 (Fisher's exact test), Q value = 0.00023
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 136 | 156 | 156 | 22 |
subtype1 | 47 | 33 | 67 | 15 |
subtype2 | 34 | 53 | 34 | 1 |
subtype3 | 55 | 70 | 55 | 6 |
P value = 1e-05 (Fisher's exact test), Q value = 4.7e-05
nPatients | 0 | 1 |
---|---|---|
ALL | 213 | 212 |
subtype1 | 58 | 97 |
subtype2 | 79 | 18 |
subtype3 | 76 | 97 |
P value = 0.333 (Fisher's exact test), Q value = 0.48
nPatients | 0 | 1 |
---|---|---|
ALL | 263 | 9 |
subtype1 | 113 | 2 |
subtype2 | 49 | 3 |
subtype3 | 101 | 4 |
P value = 0.328 (Fisher's exact test), Q value = 0.48
nPatients | FEMALE | MALE |
---|---|---|
ALL | 345 | 127 |
subtype1 | 124 | 40 |
subtype2 | 83 | 39 |
subtype3 | 138 | 48 |
P value = 0.747 (Fisher's exact test), Q value = 0.84
nPatients | NO | YES |
---|---|---|
ALL | 172 | 284 |
subtype1 | 60 | 97 |
subtype2 | 40 | 75 |
subtype3 | 72 | 112 |
P value = 1e-05 (Fisher's exact test), Q value = 4.7e-05
nPatients | OTHER, SPECIFY | THYROID PAPILLARY CARCINOMA - CLASSICAL/USUAL | THYROID PAPILLARY CARCINOMA - FOLLICULAR (>= 99% FOLLICULAR PATTERNED) | THYROID PAPILLARY CARCINOMA - TALL CELL (>= 50% TALL CELL FEATURES) |
---|---|---|---|---|
ALL | 7 | 341 | 92 | 32 |
subtype1 | 3 | 129 | 7 | 25 |
subtype2 | 2 | 51 | 69 | 0 |
subtype3 | 2 | 161 | 16 | 7 |
P value = 0.729 (Fisher's exact test), Q value = 0.83
nPatients | NO | YES |
---|---|---|
ALL | 397 | 16 |
subtype1 | 137 | 6 |
subtype2 | 100 | 5 |
subtype3 | 160 | 5 |
P value = 1e-05 (Fisher's exact test), Q value = 4.7e-05
nPatients | MINIMAL (T3) | MODERATE/ADVANCED (T4A) | NONE | VERY ADVANCED (T4B) |
---|---|---|---|---|
ALL | 125 | 17 | 312 | 1 |
subtype1 | 63 | 14 | 80 | 1 |
subtype2 | 16 | 0 | 99 | 0 |
subtype3 | 46 | 3 | 133 | 0 |
P value = 0.202 (Fisher's exact test), Q value = 0.34
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 360 | 49 | 4 | 29 |
subtype1 | 116 | 25 | 2 | 11 |
subtype2 | 93 | 9 | 0 | 8 |
subtype3 | 151 | 15 | 2 | 10 |
P value = 9.07e-08 (Kruskal-Wallis (anova)), Q value = 2.6e-06
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 363 | 3.7 (6.2) |
subtype1 | 134 | 4.4 (5.9) |
subtype2 | 76 | 1.4 (3.3) |
subtype3 | 153 | 4.2 (7.2) |
P value = 0.648 (Fisher's exact test), Q value = 0.78
nPatients | MULTIFOCAL | UNIFOCAL |
---|---|---|
ALL | 215 | 249 |
subtype1 | 71 | 92 |
subtype2 | 58 | 61 |
subtype3 | 86 | 96 |
P value = 0.0221 (Kruskal-Wallis (anova)), Q value = 0.054
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 378 | 3.0 (1.6) |
subtype1 | 125 | 2.8 (1.6) |
subtype2 | 102 | 3.2 (1.5) |
subtype3 | 151 | 2.9 (1.6) |
P value = 0.134 (Fisher's exact test), Q value = 0.25
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 1 | 49 | 26 | 313 |
subtype1 | 0 | 24 | 5 | 123 |
subtype2 | 0 | 8 | 9 | 65 |
subtype3 | 1 | 17 | 12 | 125 |
P value = 0.523 (Fisher's exact test), Q value = 0.66
nPatients | HISPANIC OR LATINO | NOT HISPANIC OR LATINO |
---|---|---|
ALL | 35 | 343 |
subtype1 | 11 | 135 |
subtype2 | 7 | 76 |
subtype3 | 17 | 132 |
-
Cluster data file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/GDAC_mergedClustering/THCA-TP/22542946/THCA-TP.mergedcluster.txt
-
Clinical data file = /xchip/cga/gdac-prod/tcga-gdac/jobResults/Append_Data/THCA-TP/22507188/THCA-TP.merged_data.txt
-
Number of patients = 503
-
Number of clustering approaches = 10
-
Number of selected clinical features = 17
-
Exclude small clusters that include fewer than K patients, K = 3
consensus non-negative matrix factorization clustering approach (Brunet et al. 2004)
Resampling-based clustering method (Monti et al. 2003)
For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene mutations were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R
For binary clinical features, two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R
For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.
In addition to the links below, the full results of the analysis summarized in this report can also be downloaded programmatically using firehose_get, or interactively from either the Broad GDAC website or TCGA Data Coordination Center Portal.