Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.107 0.257 -9999.0 0.0 -0.68 36.0 36.0 IHH -0.2 0.365 -9999.0 0.0 -0.832 124.0 124.0 SHH Np/Cholesterol/GAS1 -0.104 0.203 -9999.0 0.0 -0.512 98.0 98.0 LRPAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.103 0.202 0.508 98.0 -9999.0 0.0 98.0 SMO/beta Arrestin2 -0.094 0.24 -9999.0 0.0 -0.479 127.0 127.0 SMO -0.105 0.252 -9999.0 0.0 -0.509 128.0 128.0 AKT1 -0.026 0.123 -9999.0 0.0 -0.662 2.0 2.0 ARRB2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.0 0.104 -9999.0 0.0 -0.816 8.0 8.0 ADRBK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.103 0.248 -9999.0 0.0 -0.501 128.0 128.0 STIL -0.076 0.197 -9999.0 0.0 -0.594 18.0 18.0 DHH N/PTCH2 -0.106 0.239 -9999.0 0.0 -0.638 83.0 83.0 DHH N/PTCH1 -0.098 0.224 -9999.0 0.0 -0.449 130.0 130.0 PIK3CA 0.008 0.064 -9999.0 0.0 -0.816 3.0 3.0 DHH 0.007 0.074 -9999.0 0.0 -0.816 4.0 4.0 PTHLH -0.155 0.366 -9999.0 0.0 -1.161 36.0 36.0 determination of left/right symmetry -0.103 0.248 -9999.0 0.0 -0.501 128.0 128.0 PIK3R1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.152 0.359 -9999.0 0.0 -1.136 36.0 36.0 IHH N/Hhip -0.381 0.396 -9999.0 0.0 -0.731 265.0 265.0 DHH N/Hhip -0.249 0.309 -9999.0 0.0 -0.631 197.0 197.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.103 0.248 -9999.0 0.0 -0.501 128.0 128.0 pancreas development -0.313 0.401 -9999.0 0.0 -0.81 197.0 197.0 HHAT 0.012 0.037 -9999.0 0.0 -0.816 1.0 1.0 PI3K -0.004 0.048 -9999.0 0.0 -0.626 3.0 3.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.147 0.328 -9999.0 0.0 -0.816 97.0 97.0 somite specification -0.103 0.248 -9999.0 0.0 -0.501 128.0 128.0 SHH Np/Cholesterol/PTCH1 -0.086 0.202 -9999.0 0.0 -0.403 128.0 128.0 SHH Np/Cholesterol/PTCH2 -0.087 0.188 -9999.0 0.0 -0.509 82.0 82.0 SHH Np/Cholesterol/Megalin -0.141 0.227 -9999.0 0.0 -0.513 135.0 135.0 SHH 0.007 0.049 -9999.0 0.0 -0.626 1.0 1.0 catabolic process -0.112 0.247 -9999.0 0.0 -0.504 128.0 128.0 SMO/Vitamin D3 -0.09 0.221 -9999.0 0.0 -0.44 127.0 127.0 SHH Np/Cholesterol/Hhip -0.203 0.244 -9999.0 0.0 -0.506 196.0 196.0 LRP2 -0.209 0.367 -9999.0 0.0 -0.816 134.0 134.0 receptor-mediated endocytosis -0.197 0.233 -9999.0 0.0 -0.715 49.0 49.0 SHH Np/Cholesterol/BOC -0.014 0.073 -9999.0 0.0 -0.52 9.0 9.0 SHH Np/Cholesterol/CDO -0.155 0.232 -9999.0 0.0 -0.51 149.0 149.0 mesenchymal cell differentiation 0.201 0.242 0.502 196.0 -9999.0 0.0 196.0 mol:Vitamin D3 -0.085 0.205 -9999.0 0.0 -0.408 128.0 128.0 IHH N/PTCH2 -0.228 0.343 -9999.0 0.0 -0.66 182.0 182.0 CDON -0.232 0.379 -9999.0 0.0 -0.816 148.0 148.0 IHH N/PTCH1 -0.114 0.25 -9999.0 0.0 -0.511 128.0 128.0 Megalin/LRPAP1 -0.167 0.277 -9999.0 0.0 -0.626 134.0 134.0 PTCH2 -0.121 0.305 -9999.0 0.0 -0.816 81.0 81.0 SHH Np/Cholesterol -0.006 0.035 -9999.0 0.0 -0.507 1.0 1.0 PTCH1 -0.112 0.248 -9999.0 0.0 -0.506 128.0 128.0 HHIP -0.314 0.402 -9999.0 0.0 -0.811 197.0 197.0