Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.087 0.208 -9999.0 0.0 -0.623 30.0 30.0 IHH -0.15 0.312 -9999.0 0.0 -0.701 119.0 119.0 SHH Np/Cholesterol/GAS1 -0.053 0.158 -9999.0 0.0 -0.395 84.0 84.0 LRPAP1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.053 0.157 0.392 84.0 -9999.0 0.0 84.0 SMO/beta Arrestin2 -0.073 0.205 -9999.0 0.0 -0.524 16.0 16.0 SMO -0.094 0.206 -9999.0 0.0 -0.439 113.0 113.0 AKT1 -0.015 0.105 -9999.0 0.0 -0.609 2.0 2.0 ARRB2 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.016 0.088 -9999.0 0.0 -0.674 8.0 8.0 ADRBK1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.093 0.204 -9999.0 0.0 -0.433 113.0 113.0 STIL -0.064 0.159 -9999.0 0.0 -0.488 14.0 14.0 DHH N/PTCH2 -0.05 0.204 -9999.0 0.0 -0.511 80.0 80.0 DHH N/PTCH1 -0.075 0.188 -9999.0 0.0 -0.375 120.0 120.0 PIK3CA 0.023 0.054 -9999.0 0.0 -0.674 3.0 3.0 DHH 0.021 0.063 -9999.0 0.0 -0.674 4.0 4.0 PTHLH -0.136 0.31 -9999.0 0.0 -1.05 32.0 32.0 determination of left/right symmetry -0.093 0.204 -9999.0 0.0 -0.433 113.0 113.0 PIK3R1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.134 0.305 -9999.0 0.0 -1.031 32.0 32.0 IHH N/Hhip -0.291 0.332 -9999.0 0.0 -0.591 258.0 258.0 DHH N/Hhip -0.172 0.266 -9999.0 0.0 -0.507 190.0 190.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.093 0.204 -9999.0 0.0 -0.433 113.0 113.0 pancreas development -0.249 0.332 -9999.0 0.0 -0.671 189.0 189.0 HHAT 0.024 0.032 -9999.0 0.0 -0.674 1.0 1.0 PI3K 0.036 0.043 -9999.0 0.0 -0.509 3.0 3.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.1 0.263 -9999.0 0.0 -0.631 95.0 95.0 somite specification -0.093 0.204 -9999.0 0.0 -0.433 113.0 113.0 SHH Np/Cholesterol/PTCH1 -0.069 0.159 -9999.0 0.0 -0.498 13.0 13.0 SHH Np/Cholesterol/PTCH2 -0.043 0.149 -9999.0 0.0 -0.377 79.0 79.0 SHH Np/Cholesterol/Megalin -0.081 0.179 -9999.0 0.0 -0.381 126.0 126.0 SHH -0.005 0.029 -9999.0 0.0 -0.509 1.0 1.0 catabolic process -0.092 0.202 -9999.0 0.0 -0.416 124.0 124.0 SMO/Vitamin D3 -0.074 0.183 -9999.0 0.0 -0.545 12.0 12.0 SHH Np/Cholesterol/Hhip -0.139 0.201 -9999.0 0.0 -0.391 189.0 189.0 LRP2 -0.155 0.305 -9999.0 0.0 -0.662 131.0 131.0 receptor-mediated endocytosis -0.138 0.209 -9999.0 0.0 -0.601 41.0 41.0 SHH Np/Cholesterol/BOC 0.014 0.056 -9999.0 0.0 -0.373 9.0 9.0 SHH Np/Cholesterol/CDO -0.095 0.185 -9999.0 0.0 -0.376 145.0 145.0 mesenchymal cell differentiation 0.138 0.2 0.388 189.0 -9999.0 0.0 189.0 mol:Vitamin D3 -0.063 0.167 -9999.0 0.0 -0.503 13.0 13.0 IHH N/PTCH2 -0.167 0.286 -9999.0 0.0 -0.534 176.0 176.0 CDON -0.179 0.318 -9999.0 0.0 -0.672 146.0 146.0 IHH N/PTCH1 -0.09 0.207 -9999.0 0.0 -0.421 124.0 124.0 Megalin/LRPAP1 -0.102 0.238 -9999.0 0.0 -0.497 131.0 131.0 PTCH2 -0.084 0.255 -9999.0 0.0 -0.67 79.0 79.0 SHH Np/Cholesterol 0.009 0.023 -9999.0 0.0 -0.403 1.0 1.0 PTCH1 -0.093 0.203 -9999.0 0.0 -0.417 124.0 124.0 HHIP -0.249 0.332 -9999.0 0.0 -0.672 189.0 189.0