Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.029 0.009 -9999.0 0.0 -9999.0 0.0 0.0 epithelial cell differentiation 0.055 0.016 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ENAH 0.022 0.078 0.461 11.0 -9999.0 0.0 11.0 EGFR 0.019 0.07 -9999.0 0.0 -0.674 5.0 5.0 EPHA2 0.026 0.013 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 0.031 0.065 0.422 11.0 -9999.0 0.0 11.0 CTNNB1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.053 0.013 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 0.001 0.111 -9999.0 0.0 -0.531 19.0 19.0 CTNND1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.024 0.046 0.377 7.0 -9999.0 0.0 7.0 regulation of calcium-dependent cell-cell adhesion -0.011 0.054 0.394 5.0 -9999.0 0.0 5.0 EGF -0.076 0.246 -9999.0 0.0 -0.67 72.0 72.0 NCKAP1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.041 0.17 -9999.0 0.0 -0.529 49.0 49.0 cortical microtubule organization 0.055 0.016 -9999.0 0.0 -9999.0 0.0 0.0 GO:0000145 0.012 0.046 0.368 7.0 -9999.0 0.0 7.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.061 0.017 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP 0.006 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.061 0.025 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.013 0.031 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ZYX 0.021 0.021 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP 0.067 0.028 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 EGFR/EGFR/EGF/EGF -0.011 0.145 -9999.0 0.0 -0.357 74.0 74.0 RhoA/GDP 0.057 0.016 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization 0.021 0.05 0.384 8.0 -9999.0 0.0 8.0 IGF-1R heterotetramer 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.127 0.288 -9999.0 0.0 -0.671 108.0 108.0 DIAPH1 0.05 0.05 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway -0.055 0.016 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP 0.006 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL 0.021 0.051 0.386 8.0 -9999.0 0.0 8.0 EFNA1 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 LPP 0.011 0.06 0.352 4.0 -0.358 8.0 12.0 Ephrin A1/EPHA2 0.047 0.019 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 0.014 0.006 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.011 0.055 0.397 5.0 -9999.0 0.0 5.0 HGF/MET -0.006 0.145 -9999.0 0.0 -0.375 64.0 64.0 HGF -0.073 0.244 -9999.0 0.0 -0.674 70.0 70.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.029 0.009 -9999.0 0.0 -9999.0 0.0 0.0 actin cable formation 0.068 0.133 0.485 31.0 -0.327 1.0 32.0 KIAA1543 0.013 0.052 0.367 8.0 -0.352 1.0 9.0 KIFC3 0.021 0.023 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.024 0.038 0.356 4.0 -9999.0 0.0 4.0 NCK1/GIT1 0.038 0.01 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.055 0.016 -9999.0 0.0 -9999.0 0.0 0.0 EXOC4 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.021 0.023 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.024 0.047 0.38 7.0 -9999.0 0.0 7.0 LIMA1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.045 0.102 0.441 22.0 -9999.0 0.0 22.0 adherens junction assembly 0.027 0.085 0.458 12.0 -0.563 1.0 13.0 IGF-1R heterotetramer/IGF1 -0.036 0.165 -9999.0 0.0 -0.357 102.0 102.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.038 0.011 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.029 0.074 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 0.026 0.052 0.376 8.0 -0.369 1.0 9.0 mol:GTP 0.059 0.024 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity 0.033 0.067 0.482 7.0 -9999.0 0.0 7.0 cortical actin cytoskeleton stabilization 0.029 0.009 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-cell adhesion 0.021 0.05 0.384 8.0 -9999.0 0.0 8.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.029 0.009 -9999.0 0.0 -9999.0 0.0 0.0