Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity 0.208 0.291 0.57 46.0 -9999.0 0.0 46.0 KIRREL -0.243 0.351 -9999.0 0.0 -0.729 41.0 41.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs -0.209 0.292 -9999.0 0.0 -0.571 46.0 46.0 PLCG1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP -0.15 0.228 -9999.0 0.0 -0.431 46.0 46.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.114 0.191 -9999.0 0.0 -0.347 46.0 46.0 FYN -0.145 0.213 -9999.0 0.0 -0.409 46.0 46.0 mol:Ca2+ -0.149 0.225 -9999.0 0.0 -0.427 46.0 46.0 mol:DAG -0.149 0.227 -9999.0 0.0 -0.429 46.0 46.0 NPHS2 -0.025 0.034 -9999.0 0.0 -9999.0 0.0 0.0 mol:IP3 -0.149 0.227 -9999.0 0.0 -0.429 46.0 46.0 regulation of endocytosis -0.128 0.204 -9999.0 0.0 -0.38 46.0 46.0 Nephrin/NEPH1/podocin/Cholesterol -0.159 0.227 -9999.0 0.0 -0.439 46.0 46.0 establishment of cell polarity -0.208 0.291 -9999.0 0.0 -0.57 46.0 46.0 Nephrin/NEPH1/podocin/NCK1-2 -0.133 0.22 -9999.0 0.0 -0.4 46.0 46.0 Nephrin/NEPH1/beta Arrestin2 -0.129 0.207 -9999.0 0.0 -0.385 46.0 46.0 NPHS1 -0.055 0.176 -9999.0 0.0 -0.677 8.0 8.0 Nephrin/NEPH1/podocin -0.145 0.215 -9999.0 0.0 -0.411 46.0 46.0 TJP1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.009 0.067 -9999.0 0.0 -0.723 1.0 1.0 NCK2 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 -0.15 0.228 -9999.0 0.0 -0.431 46.0 46.0 CD2AP 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 -0.15 0.228 -9999.0 0.0 -0.431 46.0 46.0 GRB2 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.149 0.211 -9999.0 0.0 -0.4 48.0 48.0 cytoskeleton organization -0.139 0.231 -9999.0 0.0 -0.421 46.0 46.0 Nephrin/NEPH1 -0.153 0.219 -9999.0 0.0 -0.423 46.0 46.0 Nephrin/NEPH1/ZO-1 -0.162 0.244 -9999.0 0.0 -0.463 46.0 46.0