Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.2 0.326 -9999.0 0.0 -0.586 47.0 47.0 IHH -0.028 0.063 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/GAS1 0.007 0.071 -9999.0 0.0 -0.434 3.0 3.0 LRPAP1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.007 0.07 0.431 3.0 -9999.0 0.0 3.0 SMO/beta Arrestin2 -0.072 0.164 -9999.0 0.0 -9999.0 0.0 0.0 SMO -0.084 0.171 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 -0.025 0.094 -9999.0 0.0 -0.335 1.0 1.0 ARRB2 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.01 0.133 -9999.0 0.0 -0.723 4.0 4.0 ADRBK1 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.083 0.169 -9999.0 0.0 -0.397 1.0 1.0 STIL -0.058 0.131 -9999.0 0.0 -0.34 2.0 2.0 DHH N/PTCH2 -0.021 0.149 -9999.0 0.0 -0.544 9.0 9.0 DHH N/PTCH1 -0.096 0.186 -9999.0 0.0 -0.539 7.0 7.0 PIK3CA 0.009 0.067 -9999.0 0.0 -0.723 1.0 1.0 DHH -0.016 0.147 -9999.0 0.0 -0.723 5.0 5.0 PTHLH -0.406 0.577 -9999.0 0.0 -1.117 47.0 47.0 determination of left/right symmetry -0.083 0.169 -9999.0 0.0 -0.397 1.0 1.0 PIK3R1 0.003 0.095 -9999.0 0.0 -0.723 2.0 2.0 skeletal system development -0.398 0.566 -9999.0 0.0 -1.097 47.0 47.0 IHH N/Hhip -0.111 0.235 -9999.0 0.0 -0.604 22.0 22.0 DHH N/Hhip -0.105 0.243 -9999.0 0.0 -0.561 26.0 26.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.083 0.169 -9999.0 0.0 -0.397 1.0 1.0 pancreas development -0.121 0.285 -9999.0 0.0 -0.722 22.0 22.0 HHAT 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.009 0.105 -9999.0 0.0 -0.765 2.0 2.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.003 0.115 -9999.0 0.0 -0.723 3.0 3.0 somite specification -0.083 0.169 -9999.0 0.0 -0.397 1.0 1.0 SHH Np/Cholesterol/PTCH1 -0.068 0.138 -9999.0 0.0 -0.364 2.0 2.0 SHH Np/Cholesterol/PTCH2 0.003 0.081 -9999.0 0.0 -0.434 4.0 4.0 SHH Np/Cholesterol/Megalin 0.008 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SHH 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 catabolic process -0.097 0.176 -9999.0 0.0 -0.396 5.0 5.0 SMO/Vitamin D3 -0.07 0.151 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/Hhip -0.065 0.175 -9999.0 0.0 -0.434 22.0 22.0 LRP2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 receptor-mediated endocytosis -0.066 0.147 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/BOC 0.003 0.081 -9999.0 0.0 -0.434 4.0 4.0 SHH Np/Cholesterol/CDO 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mesenchymal cell differentiation 0.065 0.174 0.431 22.0 -9999.0 0.0 22.0 mol:Vitamin D3 -0.066 0.14 -9999.0 0.0 -0.365 2.0 2.0 IHH N/PTCH2 -0.02 0.111 -9999.0 0.0 -0.593 4.0 4.0 CDON 0.015 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.097 0.178 -9999.0 0.0 -0.399 5.0 5.0 Megalin/LRPAP1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 -0.01 0.132 -9999.0 0.0 -0.723 4.0 4.0 SHH Np/Cholesterol 0.01 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PTCH1 -0.097 0.177 -9999.0 0.0 -0.397 5.0 5.0 HHIP -0.121 0.285 -9999.0 0.0 -0.723 22.0 22.0