Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Angiopoietin receptor Tie2-mediated signaling	36.0	3190.0	88.0	-0.612	0.102	1000.0	-1000.0	-0.068	-1000.0
Class IB PI3K non-lipid kinase events	34.0	102.0	3.0	-0.194	-1000.0	1000.0	-1000.0	-0.012	-1000.0
Signaling mediated by p38-alpha and p38-beta	33.0	1481.0	44.0	-0.459	0.015	1000.0	-1000.0	-0.022	-1000.0
Nongenotropic Androgen signaling	31.0	1650.0	52.0	-0.488	0.305	1000.0	-1000.0	-0.035	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	28.0	972.0	34.0	-0.243	0.015	1000.0	-1000.0	-0.019	-1000.0
PDGFR-alpha signaling pathway	28.0	1273.0	44.0	-0.711	0.042	1000.0	-1000.0	-0.035	-1000.0
IL4-mediated signaling events	25.0	2338.0	91.0	-0.925	0.572	1000.0	-1000.0	-0.098	-1000.0
Endothelins	23.0	2283.0	96.0	-0.621	0.065	1000.0	-1000.0	-0.061	-1000.0
Calcium signaling in the CD4+ TCR pathway	22.0	696.0	31.0	-0.503	0.015	1000.0	-1000.0	-0.052	-1000.0
IL6-mediated signaling events	22.0	1673.0	75.0	-0.373	0.041	1000.0	-1000.0	-0.051	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	22.0	1512.0	68.0	-0.599	0.11	1000.0	-1000.0	-0.082	-1000.0
Reelin signaling pathway	21.0	1231.0	56.0	-0.3	0.027	1000.0	-1000.0	-0.054	-1000.0
Thromboxane A2 receptor signaling	20.0	2164.0	105.0	-0.282	0.081	1000.0	-1000.0	-0.05	-1000.0
Signaling events regulated by Ret tyrosine kinase	19.0	1604.0	82.0	-0.385	0.015	1000.0	-1000.0	-0.066	-1000.0
IL23-mediated signaling events	17.0	1049.0	60.0	-0.622	0.022	1000.0	-1000.0	-0.111	-1000.0
Osteopontin-mediated events	16.0	643.0	38.0	-0.373	0.017	1000.0	-1000.0	-0.057	-1000.0
TCGA08_retinoblastoma	15.0	127.0	8.0	-0.074	0.04	1000.0	-1000.0	-0.009	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	13.0	709.0	54.0	-0.3	0.028	1000.0	-1000.0	-0.073	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	13.0	678.0	52.0	-0.298	0.048	1000.0	-1000.0	-0.041	-1000.0
FOXM1 transcription factor network	13.0	701.0	51.0	-0.558	0.018	1000.0	-1000.0	-0.123	-1000.0
Coregulation of Androgen receptor activity	12.0	931.0	76.0	-0.424	0.031	1000.0	-1000.0	-0.025	-1000.0
JNK signaling in the CD4+ TCR pathway	12.0	208.0	17.0	-0.146	0.015	1000.0	-1000.0	-0.017	-1000.0
Fc-epsilon receptor I signaling in mast cells	12.0	1167.0	97.0	-0.373	0.033	1000.0	-1000.0	-0.063	-1000.0
amb2 Integrin signaling	12.0	1015.0	82.0	-0.328	0.016	1000.0	-1000.0	-0.045	-1000.0
Glucocorticoid receptor regulatory network	12.0	1419.0	114.0	-0.61	0.216	1000.0	-1000.0	-0.056	-1000.0
Wnt signaling	12.0	85.0	7.0	-0.213	0.014	1000.0	-1000.0	-0.015	-1000.0
Ras signaling in the CD4+ TCR pathway	12.0	220.0	17.0	-0.235	0.013	1000.0	-1000.0	-0.024	-1000.0
Noncanonical Wnt signaling pathway	11.0	305.0	26.0	-0.214	0.015	1000.0	-1000.0	-0.024	-1000.0
HIF-1-alpha transcription factor network	11.0	882.0	76.0	-0.429	0.025	1000.0	-1000.0	-0.063	-1000.0
S1P1 pathway	11.0	418.0	36.0	-0.376	0.015	1000.0	-1000.0	-0.042	-1000.0
Arf6 signaling events	10.0	627.0	62.0	-0.355	0.024	1000.0	-1000.0	-0.021	-1000.0
Integrins in angiogenesis	10.0	909.0	84.0	-0.169	0.022	1000.0	-1000.0	-0.064	-1000.0
TCR signaling in naïve CD8+ T cells	10.0	965.0	93.0	-0.162	0.026	1000.0	-1000.0	-0.06	-1000.0
PDGFR-beta signaling pathway	10.0	1039.0	97.0	-0.161	0.015	1000.0	-1000.0	-0.059	-1000.0
ErbB2/ErbB3 signaling events	9.0	586.0	65.0	-0.266	0.022	1000.0	-1000.0	-0.049	-1000.0
BARD1 signaling events	9.0	516.0	57.0	-0.127	0.086	1000.0	-1000.0	-0.03	-1000.0
Signaling events mediated by PTP1B	9.0	746.0	76.0	-0.32	0.025	1000.0	-1000.0	-0.061	-1000.0
BMP receptor signaling	9.0	780.0	81.0	-0.324	0.044	1000.0	-1000.0	-0.073	-1000.0
Glypican 1 network	9.0	432.0	48.0	-0.222	0.022	1000.0	-1000.0	-0.026	-1000.0
BCR signaling pathway	9.0	973.0	99.0	-0.262	0.028	1000.0	-1000.0	-0.07	-1000.0
FAS signaling pathway (CD95)	8.0	383.0	47.0	-0.497	0.04	1000.0	-1000.0	-0.027	-1000.0
Retinoic acid receptors-mediated signaling	8.0	516.0	58.0	-0.282	0.031	1000.0	-1000.0	-0.059	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	8.0	1058.0	120.0	-0.563	0.252	1000.0	-1000.0	-0.052	-1000.0
Regulation of Androgen receptor activity	8.0	614.0	70.0	-0.3	0.03	1000.0	-1000.0	-0.05	-1000.0
IL12-mediated signaling events	7.0	629.0	87.0	-0.69	0.032	1000.0	-1000.0	-0.101	-1000.0
Insulin Pathway	7.0	574.0	74.0	-0.483	0.039	1000.0	-1000.0	-0.067	-1000.0
Signaling events mediated by the Hedgehog family	6.0	358.0	52.0	-0.406	0.065	1000.0	-1000.0	-0.025	-1000.0
Syndecan-2-mediated signaling events	6.0	414.0	69.0	-0.307	0.023	1000.0	-1000.0	-0.023	-1000.0
a4b1 and a4b7 Integrin signaling	6.0	30.0	5.0	-0.04	0.003	1000.0	-1000.0	-0.011	-1000.0
Presenilin action in Notch and Wnt signaling	6.0	383.0	61.0	-0.373	0.046	1000.0	-1000.0	-0.042	-1000.0
FOXA2 and FOXA3 transcription factor networks	6.0	281.0	46.0	-0.833	0.023	1000.0	-1000.0	-0.02	-1000.0
Glypican 2 network	6.0	24.0	4.0	-0.034	-0.032	1000.0	-1000.0	-0.011	-1000.0
Syndecan-4-mediated signaling events	6.0	451.0	67.0	-0.307	0.025	1000.0	-1000.0	-0.039	-1000.0
Signaling events mediated by PRL	6.0	224.0	34.0	-0.16	0.023	1000.0	-1000.0	-0.015	-1000.0
Aurora B signaling	6.0	453.0	67.0	-0.482	0.026	1000.0	-1000.0	-0.038	-1000.0
Regulation of nuclear SMAD2/3 signaling	5.0	729.0	136.0	-0.418	0.051	1000.0	-1000.0	-0.027	-1000.0
Nectin adhesion pathway	5.0	362.0	63.0	-0.128	0.034	1000.0	-1000.0	-0.049	-1000.0
IL2 signaling events mediated by PI3K	5.0	299.0	58.0	-0.204	0.023	1000.0	-1000.0	-0.055	-1000.0
LPA receptor mediated events	5.0	579.0	102.0	-0.373	0.028	1000.0	-1000.0	-0.061	-1000.0
LPA4-mediated signaling events	4.0	56.0	12.0	-0.166	0.019	1000.0	-1000.0	-0.011	-1000.0
Syndecan-1-mediated signaling events	4.0	153.0	34.0	-0.211	0.015	1000.0	-1000.0	-0.025	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	4.0	368.0	85.0	-0.415	0.038	1000.0	-1000.0	-0.05	-1000.0
Ephrin B reverse signaling	4.0	212.0	48.0	-0.128	0.019	1000.0	-1000.0	-0.042	-1000.0
IL27-mediated signaling events	4.0	219.0	51.0	-0.3	0.099	1000.0	-1000.0	-0.064	-1000.0
IGF1 pathway	4.0	280.0	57.0	-0.031	0.031	1000.0	-1000.0	-0.061	-1000.0
Plasma membrane estrogen receptor signaling	4.0	359.0	86.0	-0.077	0.034	1000.0	-1000.0	-0.052	-1000.0
ErbB4 signaling events	3.0	239.0	69.0	-0.197	0.04	1000.0	-1000.0	-0.056	-1000.0
p75(NTR)-mediated signaling	3.0	489.0	125.0	-0.211	0.045	1000.0	-1000.0	-0.074	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	3.0	129.0	37.0	-0.04	0.026	1000.0	-1000.0	-0.018	-1000.0
IL1-mediated signaling events	3.0	207.0	62.0	-0.084	0.063	1000.0	-1000.0	-0.062	-1000.0
HIF-2-alpha transcription factor network	3.0	149.0	43.0	-0.099	0.101	1000.0	-1000.0	-0.049	-1000.0
Paxillin-dependent events mediated by a4b1	3.0	128.0	36.0	-0.04	0.027	1000.0	-1000.0	-0.045	-1000.0
Regulation of p38-alpha and p38-beta	3.0	172.0	54.0	-0.096	0.039	1000.0	-1000.0	-0.04	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	3.0	397.0	125.0	-0.128	0.059	1000.0	-1000.0	-0.063	-1000.0
IL2 signaling events mediated by STAT5	3.0	86.0	22.0	-0.067	0.019	1000.0	-1000.0	-0.026	-1000.0
Visual signal transduction: Rods	3.0	186.0	52.0	-0.268	0.019	1000.0	-1000.0	-0.052	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	3.0	309.0	78.0	-0.102	0.042	1000.0	-1000.0	-0.048	-1000.0
Cellular roles of Anthrax toxin	2.0	86.0	39.0	-0.163	0.02	1000.0	-1000.0	-0.016	-1000.0
Hedgehog signaling events mediated by Gli proteins	2.0	150.0	65.0	-0.034	0.059	1000.0	-1000.0	-0.05	-1000.0
Aurora C signaling	2.0	20.0	7.0	-0.047	0.0	1000.0	-1000.0	-0.024	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	2.0	205.0	83.0	-0.165	0.061	1000.0	-1000.0	-0.049	-1000.0
Atypical NF-kappaB pathway	2.0	81.0	31.0	-0.053	0.03	1000.0	-1000.0	-0.015	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	2.0	111.0	45.0	-0.072	0.061	1000.0	-1000.0	-0.06	-1000.0
Canonical Wnt signaling pathway	2.0	134.0	51.0	-0.131	0.05	1000.0	-1000.0	-0.037	-1000.0
EPHB forward signaling	2.0	190.0	85.0	-0.216	0.04	1000.0	-1000.0	-0.064	-1000.0
TCGA08_rtk_signaling	2.0	74.0	26.0	-0.25	0.034	1000.0	-1000.0	-0.014	-1000.0
Class I PI3K signaling events	2.0	179.0	73.0	-0.096	0.04	1000.0	-1000.0	-0.044	-1000.0
Regulation of Telomerase	2.0	230.0	102.0	-0.372	0.052	1000.0	-1000.0	-0.075	-1000.0
S1P3 pathway	2.0	108.0	42.0	-0.09	0.043	1000.0	-1000.0	-0.03	-1000.0
Rapid glucocorticoid signaling	2.0	58.0	20.0	-0.048	0.015	1000.0	-1000.0	-0.012	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	1.0	43.0	23.0	-0.108	0.045	1000.0	-1000.0	-0.027	-1000.0
Signaling events mediated by HDAC Class II	1.0	77.0	75.0	-0.108	0.045	1000.0	-1000.0	-0.03	-1000.0
Sphingosine 1-phosphate (S1P) pathway	1.0	46.0	28.0	-0.022	0.037	1000.0	-1000.0	-0.017	-1000.0
Aurora A signaling	1.0	73.0	60.0	-0.038	0.047	1000.0	-1000.0	-0.017	-1000.0
PLK1 signaling events	1.0	163.0	85.0	-0.035	0.033	1000.0	-1000.0	-0.025	-1000.0
mTOR signaling pathway	1.0	84.0	53.0	-0.026	0.028	1000.0	-1000.0	-0.045	-1000.0
Ceramide signaling pathway	1.0	107.0	76.0	-0.071	0.044	1000.0	-1000.0	-0.023	-1000.0
Signaling events mediated by HDAC Class III	1.0	60.0	40.0	-0.038	0.023	1000.0	-1000.0	-0.02	-1000.0
Signaling events mediated by HDAC Class I	1.0	171.0	104.0	-0.056	0.057	1000.0	-1000.0	-0.031	-1000.0
Signaling mediated by p38-gamma and p38-delta	1.0	16.0	15.0	-0.0	0.026	1000.0	-1000.0	-0.009	-1000.0
Syndecan-3-mediated signaling events	1.0	55.0	35.0	-0.076	0.045	1000.0	-1000.0	-0.026	-1000.0
Effects of Botulinum toxin	1.0	39.0	26.0	-0.061	0.026	1000.0	-1000.0	-0.044	-1000.0
VEGFR1 specific signals	1.0	70.0	56.0	-0.022	0.057	1000.0	-1000.0	-0.03	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	1.0	65.0	33.0	-0.092	0.035	1000.0	-1000.0	-0.018	-1000.0
E-cadherin signaling in keratinocytes	1.0	55.0	43.0	-0.035	0.043	1000.0	-1000.0	-0.029	-1000.0
S1P4 pathway	1.0	47.0	25.0	-0.016	0.029	1000.0	-1000.0	-0.02	-1000.0
Caspase cascade in apoptosis	0.0	61.0	74.0	-0.047	0.04	1000.0	-1000.0	-0.022	-1000.0
Canonical NF-kappaB pathway	0.0	25.0	39.0	-0.047	0.085	1000.0	-1000.0	-0.067	-1000.0
PLK2 and PLK4 events	0.0	2.0	3.0	0.008	0.014	1000.0	-1000.0	-0.006	-1000.0
Visual signal transduction: Cones	0.0	9.0	38.0	-0.02	0.015	1000.0	-1000.0	-0.018	-1000.0
Circadian rhythm pathway	0.0	7.0	22.0	-0.013	0.044	1000.0	-1000.0	-0.033	-1000.0
Ephrin A  reverse signaling	0.0	0.0	7.0	-0.022	0.011	1000.0	-1000.0	-0.008	-1000.0
Arf6 downstream pathway	0.0	14.0	43.0	-0.028	0.029	1000.0	-1000.0	-0.03	-1000.0
EPO signaling pathway	0.0	39.0	55.0	-0.01	0.077	1000.0	-1000.0	-0.061	-1000.0
Insulin-mediated glucose transport	0.0	0.0	32.0	-0.01	0.042	1000.0	-1000.0	-0.031	-1000.0
IFN-gamma pathway	0.0	57.0	68.0	-0.034	0.075	1000.0	-1000.0	-0.067	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	21.0	68.0	-0.041	0.055	1000.0	-1000.0	-0.023	-1000.0
TRAIL signaling pathway	0.0	43.0	48.0	-0.003	0.045	1000.0	-1000.0	-0.056	-1000.0
S1P5 pathway	0.0	5.0	17.0	-0.033	0.034	1000.0	-1000.0	-0.018	-1000.0
ceramide signaling pathway	0.0	31.0	49.0	-0.046	0.041	1000.0	-1000.0	-0.031	-1000.0
TCGA08_p53	0.0	5.0	7.0	-0.005	0.015	1000.0	-1000.0	-0.007	-1000.0
FoxO family signaling	0.0	51.0	64.0	-0.041	0.129	1000.0	-1000.0	-0.042	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	0.0	72.0	74.0	-0.029	0.068	1000.0	-1000.0	-0.064	-1000.0
E-cadherin signaling in the nascent adherens junction	0.0	26.0	76.0	-0.007	0.057	1000.0	-1000.0	-0.058	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	0.0	27.0	0.0	0.039	1000.0	-1000.0	-0.036	-1000.0
Arf6 trafficking events	0.0	51.0	71.0	-0.071	0.044	1000.0	-1000.0	-0.052	-1000.0
EGFR-dependent Endothelin signaling events	0.0	18.0	21.0	-0.006	0.031	1000.0	-1000.0	-0.048	-1000.0
E-cadherin signaling events	0.0	0.0	5.0	0.007	0.024	1000.0	-1000.0	-0.012	-1000.0
p38 MAPK signaling pathway	0.0	21.0	44.0	-0.034	0.029	1000.0	-1000.0	-0.046	-1000.0
Arf1 pathway	0.0	21.0	54.0	-0.003	0.029	1000.0	-1000.0	-0.022	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.044	1000.0	-1000.0	-0.019	-1000.0
Total	885	56174	7203	-27.2438365615	-993.977340706	131000	-131000	-5.39000639696	-131000