Nectin adhesion pathway Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations PDGFRB -0.04 0.181 -9999.0 0.0 -0.5 16.0 16.0 alphaV beta3 Integrin -0.034 0.161 -9999.0 0.0 -0.362 23.0 23.0 PTK2 -0.035 0.162 -9999.0 0.0 -0.498 10.0 10.0 positive regulation of JNK cascade -0.005 0.12 -9999.0 0.0 -0.326 10.0 10.0 CDC42/GDP 0.006 0.167 -9999.0 0.0 -0.439 10.0 10.0 Rac1/GDP 0.004 0.16 -9999.0 0.0 -0.435 10.0 10.0 RAP1B 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.027 0.049 -9999.0 0.0 -0.5 1.0 1.0 CTNNB1 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.001 0.15 -9999.0 0.0 -0.403 10.0 10.0 nectin-3/I-afadin 0.01 0.107 -9999.0 0.0 -0.36 9.0 9.0 RAPGEF1 -0.025 0.165 0.364 1.0 -0.471 11.0 12.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CRK -0.033 0.184 -9999.0 0.0 -0.535 11.0 11.0 PDGFB-D/PDGFRB -0.04 0.181 -9999.0 0.0 -0.499 16.0 16.0 TLN1 -0.006 0.043 -9999.0 0.0 -0.166 8.0 8.0 Rap1/GTP -0.015 0.123 -9999.0 0.0 -0.348 10.0 10.0 IQGAP1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.053 0.037 -9999.0 0.0 -0.282 1.0 1.0 nectin-3(dimer)/I-afadin/I-afadin/nectin-3(dimer)/I-afadin/I-afadin 0.01 0.107 -9999.0 0.0 -0.36 9.0 9.0 PVR 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 Necl-5(dimer) 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.014 0.193 -9999.0 0.0 -0.539 10.0 10.0 MLLT4 0.029 0.01 -9999.0 0.0 -9999.0 0.0 0.0 PIK3CA 0.027 0.049 -9999.0 0.0 -0.5 1.0 1.0 PI3K 0.002 0.158 -9999.0 0.0 -0.284 26.0 26.0 nectin-1(dimer)/I-afadin/I-afadin/nectin-1(dimer)/I-afadin/I-afadin 0.04 0.019 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of lamellipodium assembly -0.004 0.124 -9999.0 0.0 -0.335 10.0 10.0 PVRL1 0.029 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PVRL3 -0.01 0.14 -9999.0 0.0 -0.5 9.0 9.0 PVRL2 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.023 0.069 -9999.0 0.0 -0.5 2.0 2.0 CDH1 0.028 0.012 -9999.0 0.0 -9999.0 0.0 0.0 CLDN1 0.028 0.012 -9999.0 0.0 -9999.0 0.0 0.0 JAM-A/CLDN1 0.041 0.094 -9999.0 0.0 -0.283 8.0 8.0 SRC -0.035 0.201 -9999.0 0.0 -0.593 11.0 11.0 ITGB3 -0.073 0.209 -9999.0 0.0 -0.5 23.0 23.0 nectin-1(dimer)/I-afadin/I-afadin 0.04 0.019 -9999.0 0.0 -9999.0 0.0 0.0 FARP2 -0.013 0.195 -9999.0 0.0 -0.538 10.0 10.0 RAC1 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 nectin-3(dimer)/I-afadin/I-afadin/Necl-5(dimer) 0.027 0.098 -9999.0 0.0 -0.304 9.0 9.0 nectin-1/I-afadin 0.04 0.019 -9999.0 0.0 -9999.0 0.0 0.0 nectin-2/I-afadin 0.043 0.016 -9999.0 0.0 -9999.0 0.0 0.0 RAC1/GTP/IQGAP1/filamentous actin 0.04 0.013 -9999.0 0.0 -9999.0 0.0 0.0 nectin-1(dimer)/I-afadin/I-afadin/nectin-3(dimer/I-afadin/I-afadin 0.026 0.097 -9999.0 0.0 -0.299 9.0 9.0 CDC42/GTP/IQGAP1/filamentous actin 0.041 0.012 -9999.0 0.0 -9999.0 0.0 0.0 F11R 0.027 0.012 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of filopodium formation -0.005 0.12 -9999.0 0.0 -0.326 10.0 10.0 alphaV/beta3 Integrin/Talin -0.024 0.145 0.315 2.0 -0.285 23.0 25.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.043 0.016 -9999.0 0.0 -9999.0 0.0 0.0 nectin-2(dimer)/I-afadin/I-afadin 0.043 0.016 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C -0.002 0.047 -9999.0 0.0 -0.175 8.0 8.0 VAV2 -0.014 0.192 -9999.0 0.0 -0.524 10.0 10.0 RAP1/GDP 0.012 0.158 0.292 1.0 -0.408 10.0 11.0 ITGAV 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 nectin-3(dimer)/I-afadin/I-afadin/nectin-2(dimer)/I-afadin/I-afadin 0.028 0.096 -9999.0 0.0 -0.296 9.0 9.0 nectin-3(dimer)/I-afadin/I-afadin 0.01 0.107 -9999.0 0.0 -0.36 9.0 9.0 Rac1/GTP -0.003 0.151 -9999.0 0.0 -0.41 10.0 10.0 PTPRM -0.001 0.065 -9999.0 0.0 -0.216 9.0 9.0 E-cadherin/beta catenin/alpha catenin 0.08 0.039 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0