Lissencephaly gene (LIS1) in neuronal migration and development Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations DYNC1H1 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 VLDLR -0.036 0.176 -9999.0 0.0 -0.5 15.0 15.0 LRPAP1 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NUDC 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 RELN/LRP8 -0.095 0.181 -9999.0 0.0 -0.31 49.0 49.0 CaM/Ca2+ 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 KATNA1 0.029 0.011 -9999.0 0.0 -9999.0 0.0 0.0 GO:0030286 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABL1 -0.103 0.154 0.185 4.0 -0.282 49.0 53.0 IQGAP1/CaM 0.046 0.012 -9999.0 0.0 -9999.0 0.0 0.0 DAB1 0.024 0.01 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PLA2G7 0.028 0.012 -9999.0 0.0 -9999.0 0.0 0.0 CALM1 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 DYNLT1 0.029 0.011 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LRPAP1/LRP8 0.047 0.01 -9999.0 0.0 -9999.0 0.0 0.0 UniProt:Q4QZ09 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CLIP1 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CDK5R1 0.021 0.069 -9999.0 0.0 -0.5 2.0 2.0 LIS1/Poliovirus Protein 3A 0.011 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDK5R2 0.022 0.008 -9999.0 0.0 -9999.0 0.0 0.0 mol:PP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RELN/VLDLR/DAB1 -0.141 0.2 -9999.0 0.0 -0.337 58.0 58.0 YWHAE 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 NDEL1/14-3-3 E -0.071 0.139 0.325 3.0 -0.281 2.0 5.0 MAP1B -0.007 0.063 -9999.0 0.0 -0.281 6.0 6.0 RAC1 0.016 0.007 -9999.0 0.0 -9999.0 0.0 0.0 p35/CDK5 -0.092 0.134 -9999.0 0.0 -0.256 47.0 47.0 RELN -0.19 0.26 -9999.0 0.0 -0.5 49.0 49.0 PAFAH/LIS1 0.03 0.014 -9999.0 0.0 -9999.0 0.0 0.0 LIS1/CLIP170 0.033 0.011 -9999.0 0.0 -9999.0 0.0 0.0 LIS1/NDEL1/Katanin 60/Dynein Light chain/Dynein heavy chain -0.061 0.116 -9999.0 0.0 -0.248 1.0 1.0 RELN/VLDLR/DAB1/LIS1/PAFAH1B2/PAFAH1B3 -0.114 0.151 -9999.0 0.0 -0.256 57.0 57.0 GO:0005869 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NDEL1 -0.082 0.137 0.324 3.0 -0.294 2.0 5.0 LIS1/IQGAP1 0.032 0.012 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.016 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PAFAH1B1 0.015 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PAFAH1B3 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PAFAH1B2 0.019 0.084 -9999.0 0.0 -0.5 3.0 3.0 MAP1B/LIS1/Dynein heavy chain 0.024 0.054 -9999.0 0.0 -9999.0 0.0 0.0 NDEL1/Katanin 60/Dynein heavy chain -0.068 0.133 0.328 1.0 -0.275 2.0 3.0 LRP8 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NDEL1/Katanin 60 -0.074 0.133 0.324 2.0 -0.281 2.0 4.0 P39/CDK5 -0.105 0.128 -9999.0 0.0 -0.258 47.0 47.0 LIS1/NudC/Dynein intermediate chain/microtubule organizing center 0.033 0.012 -9999.0 0.0 -9999.0 0.0 0.0 CDK5 -0.114 0.128 0.183 1.0 -0.266 49.0 50.0 PPP2R5D 0.03 0.01 -9999.0 0.0 -9999.0 0.0 0.0 LIS1/CLIP170/Dynein Complex/Dynactin Complex 0.029 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CSNK2A1 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RELN/VLDLR/DAB1/LIS1 -0.115 0.18 -9999.0 0.0 -0.296 56.0 56.0 RELN/VLDLR -0.118 0.197 -9999.0 0.0 -0.31 58.0 58.0 CDC42 0.016 0.006 -9999.0 0.0 -9999.0 0.0 0.0