Presenilin action in Notch and Wnt signaling Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations Delta 1/NOTCH/NOTCH(cleaved) 0.0 0.175 -9999.0 0.0 -0.629 8.0 8.0 HDAC1 0.026 0.013 -9999.0 0.0 -9999.0 0.0 0.0 AES 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 FBXW11 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 DTX1 -0.004 0.133 -9999.0 0.0 -0.5 8.0 8.0 LRP6/FZD1 0.045 0.014 -9999.0 0.0 -9999.0 0.0 0.0 TLE1 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 AP1 -0.151 0.187 -9999.0 0.0 -0.308 62.0 62.0 NCSTN 0.027 0.012 -9999.0 0.0 -9999.0 0.0 0.0 ADAM10 -0.009 0.141 -9999.0 0.0 -0.5 9.0 9.0 Beta Catenin/TCF1/CtBP/CBP/TLE1/AES/SMAD4 0.044 0.048 -9999.0 0.0 -9999.0 0.0 0.0 NICD/RBPSUH 0.011 0.167 -9999.0 0.0 -0.585 8.0 8.0 WIF1 0.017 0.012 -9999.0 0.0 -9999.0 0.0 0.0 NOTCH1 -0.016 0.164 -9999.0 0.0 -0.613 8.0 8.0 PSENEN 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 KREMEN2 0.01 0.083 -9999.0 0.0 -0.5 3.0 3.0 DKK1 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 beta catenin/beta TrCP1 0.043 0.06 0.267 2.0 -0.257 1.0 3.0 APH1B 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 APH1A 0.028 0.012 -9999.0 0.0 -9999.0 0.0 0.0 AXIN1 0.014 0.082 0.319 2.0 -9999.0 0.0 2.0 CtBP/CBP/TCF1/TLE1/AES 0.019 0.033 -9999.0 0.0 -9999.0 0.0 0.0 PSEN1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 FOS -0.237 0.265 -9999.0 0.0 -0.5 60.0 60.0 JUN -0.04 0.181 -9999.0 0.0 -0.5 16.0 16.0 MAP3K7 0.028 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.027 0.07 0.291 3.0 -0.26 2.0 5.0 MAPK3 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 DKK2/LRP6/Kremen 2 -0.023 0.143 -9999.0 0.0 -0.325 20.0 20.0 HNF1A 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTBP1 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 MYC 0.023 0.122 -9999.0 0.0 -1.287 1.0 1.0 NKD1 0.021 0.069 -9999.0 0.0 -0.501 2.0 2.0 FZD1 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 NOTCH1 precursor/Deltex homolog 1 -0.0 0.171 -9999.0 0.0 -0.585 8.0 8.0 apoptosis -0.151 0.185 -9999.0 0.0 -0.306 62.0 62.0 Delta 1/NOTCHprecursor 0.006 0.173 -9999.0 0.0 -0.613 8.0 8.0 DLL1 0.025 0.049 -9999.0 0.0 -0.5 1.0 1.0 PPARD -0.034 0.219 -9999.0 0.0 -0.719 11.0 11.0 Gamma Secretase 0.082 0.038 -9999.0 0.0 -9999.0 0.0 0.0 APC 0.015 0.089 0.306 3.0 -0.317 1.0 4.0 DVL1 0.029 0.014 -9999.0 0.0 -9999.0 0.0 0.0 CSNK2A1 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 MAP3K7IP1 -0.002 0.002 -9999.0 0.0 -9999.0 0.0 0.0 DKK1/LRP6/Kremen 2 0.034 0.063 -9999.0 0.0 -0.303 3.0 3.0 LRP6 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CSNK1A1 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NLK 0.012 0.007 -9999.0 0.0 -9999.0 0.0 0.0 CCND1 0.026 0.103 -9999.0 0.0 -0.724 2.0 2.0 WNT1 0.027 0.049 -9999.0 0.0 -0.5 1.0 1.0 Axin1/APC/beta catenin 0.054 0.102 0.507 3.0 -9999.0 0.0 3.0 DKK2 -0.06 0.198 -9999.0 0.0 -0.5 20.0 20.0 NOTCH1 precursor/DVL1 0.008 0.142 -9999.0 0.0 -0.51 8.0 8.0 GSK3B 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 FRAT1 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NOTCH/Deltex homolog 1 -0.009 0.171 -9999.0 0.0 -0.601 8.0 8.0 PPP2R5D 0.023 0.06 0.281 2.0 -0.283 3.0 5.0 MAPK1 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 WNT1/LRP6/FZD1 0.069 0.041 -9999.0 0.0 -0.287 1.0 1.0 RBPJ 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CREBBP 0.035 0.007 -9999.0 0.0 -9999.0 0.0 0.0