IGF1 pathway Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations NCK2 0.033 0.003 -9999.0 0.0 -9999.0 0.0 0.0 PTK2 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CRKL 0.003 0.061 -9999.0 0.0 -0.225 7.0 7.0 GRB2/SOS1/SHC 0.054 0.026 -9999.0 0.0 -9999.0 0.0 0.0 HRAS 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 IRS1/Crk 0.014 0.063 -9999.0 0.0 -0.226 7.0 7.0 IGF-1R heterotetramer/IGF1/PTP1B 0.042 0.07 -9999.0 0.0 -0.296 4.0 4.0 AKT1 -0.02 0.095 0.209 1.0 -0.333 6.0 7.0 BAD -0.021 0.082 0.197 1.0 -0.314 5.0 6.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CRK 0.003 0.059 -9999.0 0.0 -0.225 7.0 7.0 IGF-1R heterotetramer/IGF1/IRS1/Shp2 0.019 0.066 -9999.0 0.0 -0.226 7.0 7.0 RAF1 -0.001 0.101 -9999.0 0.0 -0.508 3.0 3.0 IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos 0.051 0.074 -9999.0 0.0 -0.252 4.0 4.0 YWHAZ 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1/IRS1 0.019 0.072 -9999.0 0.0 -0.231 8.0 8.0 PIK3CA 0.027 0.049 -9999.0 0.0 -0.5 1.0 1.0 RPS6KB1 -0.014 0.099 0.307 2.0 -0.344 5.0 7.0 GNB2L1 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of MAPKKK cascade 0.009 0.113 0.373 4.0 -0.418 3.0 7.0 PXN 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.023 0.069 -9999.0 0.0 -0.5 2.0 2.0 cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GRB2/SOS1 0.045 0.013 -9999.0 0.0 -9999.0 0.0 0.0 HRAS/GTP 0.024 0.053 -9999.0 0.0 -0.234 4.0 4.0 IGF-1R heterotetramer/IGF1/GRB2/Sos/Shc 0.068 0.07 -9999.0 0.0 -0.24 4.0 4.0 IGF-1R heterotetramer 0.026 0.027 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1/IRS/Nck 0.038 0.073 -9999.0 0.0 -0.226 7.0 7.0 Crk/p130 Cas/Paxillin 0.05 0.07 -9999.0 0.0 -0.244 4.0 4.0 IGF1R 0.026 0.027 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.012 0.1 -9999.0 0.0 -0.515 4.0 4.0 IRS2/Crk 0.011 0.066 -9999.0 0.0 -0.253 5.0 5.0 PI3K 0.044 0.102 -9999.0 0.0 -0.289 8.0 8.0 apoptosis -0.008 0.082 0.565 1.0 -0.394 1.0 2.0 HRAS/GDP 0.023 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PRKCD 0.007 0.066 -9999.0 0.0 -0.339 4.0 4.0 RAF1/14-3-3 E 0.018 0.11 0.434 2.0 -0.434 3.0 5.0 BAD/14-3-3 0.009 0.087 0.406 1.0 -0.614 1.0 2.0 PRKCZ -0.015 0.103 0.274 3.0 -0.333 6.0 9.0 Crk/p130 Cas/Paxillin/FAK1 0.029 0.083 -9999.0 0.0 -0.306 5.0 5.0 PTPN1 0.032 0.007 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1/IRS1/GRB2/Sos/Shc/RACK1 0.011 0.07 -9999.0 0.0 -0.355 4.0 4.0 BCAR1 0.03 0.01 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1/SHC/GRB10 0.057 0.067 -9999.0 0.0 -0.259 4.0 4.0 mol:GDP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SOS1 0.033 0.003 -9999.0 0.0 -9999.0 0.0 0.0 IRS1/NCK2 0.023 0.069 -9999.0 0.0 -0.225 7.0 7.0 GRB10 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 PTPN11 0.003 0.061 -9999.0 0.0 -0.225 7.0 7.0 IRS1 0.005 0.068 -9999.0 0.0 -0.243 7.0 7.0 IRS2 0.001 0.066 -9999.0 0.0 -0.231 8.0 8.0 IGF-1R heterotetramer/IGF1 0.026 0.08 -9999.0 0.0 -0.383 4.0 4.0 GRB2 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PDPK1 0.008 0.111 0.279 3.0 -0.353 6.0 9.0 YWHAE 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 PRKD1 0.003 0.073 -9999.0 0.0 -0.339 4.0 4.0 SHC1 0.028 0.012 -9999.0 0.0 -9999.0 0.0 0.0